id	sid	tid	token	lemma	pos
h989r210w6s	1	1	the	the	DET
h989r210w6s	1	2	american	american	ADJ
h989r210w6s	1	3	cancer	cancer	NOUN
h989r210w6s	1	4	society	society	PROPN
h989r210w6s	1	5	estimates	estimate	VERB
h989r210w6s	1	6	that	that	SCONJ
h989r210w6s	1	7	there	there	PRON
h989r210w6s	1	8	will	will	AUX
h989r210w6s	1	9	be	be	AUX
h989r210w6s	1	10	more	more	ADJ
h989r210w6s	1	11	than	than	ADP
h989r210w6s	1	12	1.7	1.7	NUM
h989r210w6s	1	13	million	million	NUM
h989r210w6s	1	14	new	new	ADJ
h989r210w6s	1	15	cases	case	NOUN
h989r210w6s	1	16	of	of	ADP
h989r210w6s	1	17	cancer	cancer	NOUN
h989r210w6s	1	18	diagnosed	diagnose	VERB
h989r210w6s	1	19	in	in	ADP
h989r210w6s	1	20	2018	2018	NUM
h989r210w6s	1	21	,	,	PUNCT
h989r210w6s	1	22	so	so	SCONJ
h989r210w6s	1	23	the	the	DET
h989r210w6s	1	24	need	need	NOUN
h989r210w6s	1	25	for	for	ADP
h989r210w6s	1	26	understanding	understand	VERB
h989r210w6s	1	27	the	the	DET
h989r210w6s	1	28	molecular	molecular	ADJ
h989r210w6s	1	29	mechanisms	mechanism	NOUN
h989r210w6s	1	30	of	of	ADP
h989r210w6s	1	31	cancer	cancer	NOUN
h989r210w6s	1	32	is	be	AUX
h989r210w6s	1	33	great	great	ADJ
h989r210w6s	1	34	.	.	PUNCT
h989r210w6s	2	1	research	research	NOUN
h989r210w6s	2	2	has	have	AUX
h989r210w6s	2	3	long	long	ADV
h989r210w6s	2	4	suggested	suggest	VERB
h989r210w6s	2	5	that	that	SCONJ
h989r210w6s	2	6	the	the	DET
h989r210w6s	2	7	necrotic	necrotic	ADJ
h989r210w6s	2	8	core	core	NOUN
h989r210w6s	2	9	of	of	ADP
h989r210w6s	2	10	tumors	tumor	NOUN
h989r210w6s	2	11	may	may	AUX
h989r210w6s	2	12	not	not	PART
h989r210w6s	2	13	receive	receive	VERB
h989r210w6s	2	14	the	the	DET
h989r210w6s	2	15	full	full	ADJ
h989r210w6s	2	16	dose	dose	NOUN
h989r210w6s	2	17	of	of	ADP
h989r210w6s	2	18	treatment	treatment	NOUN
h989r210w6s	2	19	and	and	CCONJ
h989r210w6s	2	20	the	the	DET
h989r210w6s	2	21	cells	cell	NOUN
h989r210w6s	2	22	residing	reside	VERB
h989r210w6s	2	23	there	there	ADV
h989r210w6s	2	24	can	can	AUX
h989r210w6s	2	25	ultimately	ultimately	ADV
h989r210w6s	2	26	be	be	AUX
h989r210w6s	2	27	responsible	responsible	ADJ
h989r210w6s	2	28	for	for	ADP
h989r210w6s	2	29	cancer	cancer	NOUN
h989r210w6s	2	30	progression.spatial	progression.spatial	ADJ
h989r210w6s	2	31	analysis	analysis	NOUN
h989r210w6s	2	32	of	of	ADP
h989r210w6s	2	33	chemical	chemical	NOUN
h989r210w6s	2	34	species	specie	NOUN
h989r210w6s	2	35	can	can	AUX
h989r210w6s	2	36	allow	allow	VERB
h989r210w6s	2	37	one	one	PRON
h989r210w6s	2	38	to	to	PART
h989r210w6s	2	39	detect	detect	VERB
h989r210w6s	2	40	small	small	ADJ
h989r210w6s	2	41	changes	change	NOUN
h989r210w6s	2	42	over	over	ADP
h989r210w6s	2	43	time	time	NOUN
h989r210w6s	2	44	and	and	CCONJ
h989r210w6s	2	45	differences	difference	NOUN
h989r210w6s	2	46	between	between	ADP
h989r210w6s	2	47	data	datum	NOUN
h989r210w6s	2	48	sets	set	NOUN
h989r210w6s	2	49	.	.	PUNCT
h989r210w6s	3	1	this	this	DET
h989r210w6s	3	2	type	type	NOUN
h989r210w6s	3	3	of	of	ADP
h989r210w6s	3	4	analysis	analysis	NOUN
h989r210w6s	3	5	allows	allow	VERB
h989r210w6s	3	6	for	for	SCONJ
h989r210w6s	3	7	important	important	ADJ
h989r210w6s	3	8	questions	question	NOUN
h989r210w6s	3	9	to	to	PART
h989r210w6s	3	10	be	be	AUX
h989r210w6s	3	11	critically	critically	ADV
h989r210w6s	3	12	analyzed	analyze	VERB
h989r210w6s	3	13	beyond	beyond	ADP
h989r210w6s	3	14	the	the	DET
h989r210w6s	3	15	scope	scope	NOUN
h989r210w6s	3	16	of	of	ADP
h989r210w6s	3	17	a	a	DET
h989r210w6s	3	18	simple	simple	ADJ
h989r210w6s	3	19	one	one	NUM
h989r210w6s	3	20	-	-	PUNCT
h989r210w6s	3	21	dimensional	dimensional	ADJ
h989r210w6s	3	22	analysis	analysis	NOUN
h989r210w6s	3	23	.	.	PUNCT
h989r210w6s	4	1	these	these	DET
h989r210w6s	4	2	spatial	spatial	ADJ
h989r210w6s	4	3	localizations	localization	NOUN
h989r210w6s	4	4	can	can	AUX
h989r210w6s	4	5	be	be	AUX
h989r210w6s	4	6	analyzed	analyze	VERB
h989r210w6s	4	7	in	in	ADP
h989r210w6s	4	8	numerous	numerous	ADJ
h989r210w6s	4	9	ways	way	NOUN
h989r210w6s	4	10	.	.	PUNCT
h989r210w6s	5	1	however	however	ADV
h989r210w6s	5	2	,	,	PUNCT
h989r210w6s	5	3	the	the	DET
h989r210w6s	5	4	techniques	technique	NOUN
h989r210w6s	5	5	utilized	utilize	VERB
h989r210w6s	5	6	within	within	ADP
h989r210w6s	5	7	this	this	DET
h989r210w6s	5	8	document	document	NOUN
h989r210w6s	5	9	include	include	VERB
h989r210w6s	5	10	matrix	matrix	NOUN
h989r210w6s	5	11	-	-	PUNCT
h989r210w6s	5	12	assisted	assist	VERB
h989r210w6s	5	13	laser	laser	NOUN
h989r210w6s	5	14	desorption	desorption	NOUN
h989r210w6s	5	15	/	/	SYM
h989r210w6s	5	16	ionization	ionization	NOUN
h989r210w6s	5	17	-	-	PUNCT
h989r210w6s	5	18	mass	mass	NOUN
h989r210w6s	5	19	spectrometry	spectrometry	NOUN
h989r210w6s	5	20	imaging	imaging	NOUN
h989r210w6s	5	21	(	(	PUNCT
h989r210w6s	5	22	maldi	maldi	PROPN
h989r210w6s	5	23	msi	msi	PROPN
h989r210w6s	5	24	)	)	PUNCT
h989r210w6s	5	25	and	and	CCONJ
h989r210w6s	5	26	stable	stable	ADJ
h989r210w6s	5	27	isotope	isotope	NOUN
h989r210w6s	5	28	labeling	labeling	NOUN
h989r210w6s	5	29	by	by	ADP
h989r210w6s	5	30	amino	amino	NOUN
h989r210w6s	5	31	acids	acid	NOUN
h989r210w6s	5	32	in	in	ADP
h989r210w6s	5	33	cell	cell	NOUN
h989r210w6s	5	34	culture	culture	NOUN
h989r210w6s	5	35	(	(	PUNCT
h989r210w6s	5	36	silac	silac	PROPN
h989r210w6s	5	37	)	)	PUNCT
h989r210w6s	5	38	followed	follow	VERB
h989r210w6s	5	39	by	by	ADP
h989r210w6s	5	40	liquid	liquid	ADJ
h989r210w6s	5	41	chromatography	chromatography	NOUN
h989r210w6s	5	42	tandem	tandem	PROPN
h989r210w6s	5	43	mass	mass	NOUN
h989r210w6s	5	44	spectrometry	spectrometry	NOUN
h989r210w6s	5	45	(	(	PUNCT
h989r210w6s	5	46	lc	lc	PROPN
h989r210w6s	5	47	-	-	PUNCT
h989r210w6s	5	48	ms	ms	NOUN
h989r210w6s	5	49	/	/	SYM
h989r210w6s	5	50	ms).tumors	ms).tumor	NOUN
h989r210w6s	5	51	in	in	ADP
h989r210w6s	5	52	vivo	vivo	NOUN
h989r210w6s	5	53	have	have	VERB
h989r210w6s	5	54	a	a	DET
h989r210w6s	5	55	complex	complex	ADJ
h989r210w6s	5	56	microenvironment	microenvironment	NOUN
h989r210w6s	5	57	and	and	CCONJ
h989r210w6s	5	58	researchers	researcher	NOUN
h989r210w6s	5	59	have	have	AUX
h989r210w6s	5	60	spent	spend	VERB
h989r210w6s	5	61	decades	decade	NOUN
h989r210w6s	5	62	developing	develop	VERB
h989r210w6s	5	63	different	different	ADJ
h989r210w6s	5	64	models	model	NOUN
h989r210w6s	5	65	to	to	PART
h989r210w6s	5	66	test	test	VERB
h989r210w6s	5	67	the	the	DET
h989r210w6s	5	68	efficacy	efficacy	NOUN
h989r210w6s	5	69	of	of	ADP
h989r210w6s	5	70	novel	novel	ADJ
h989r210w6s	5	71	treatments	treatment	NOUN
h989r210w6s	5	72	.	.	PUNCT
h989r210w6s	6	1	the	the	DET
h989r210w6s	6	2	work	work	NOUN
h989r210w6s	6	3	described	describe	VERB
h989r210w6s	6	4	in	in	ADP
h989r210w6s	6	5	this	this	DET
h989r210w6s	6	6	document	document	NOUN
h989r210w6s	6	7	utilizes	utilize	VERB
h989r210w6s	6	8	a	a	DET
h989r210w6s	6	9	three	three	NUM
h989r210w6s	6	10	-	-	PUNCT
h989r210w6s	6	11	dimensional	dimensional	ADJ
h989r210w6s	6	12	cell	cell	NOUN
h989r210w6s	6	13	culture	culture	NOUN
h989r210w6s	6	14	system	system	NOUN
h989r210w6s	6	15	.	.	PUNCT
h989r210w6s	7	1	these	these	DET
h989r210w6s	7	2	multicellular	multicellular	ADJ
h989r210w6s	7	3	aggregates	aggregate	NOUN
h989r210w6s	7	4	referred	refer	VERB
h989r210w6s	7	5	to	to	ADP
h989r210w6s	7	6	as	as	ADP
h989r210w6s	7	7	tumor	tumor	NOUN
h989r210w6s	7	8	spheroids	spheroid	NOUN
h989r210w6s	7	9	,	,	PUNCT
h989r210w6s	7	10	display	display	VERB
h989r210w6s	7	11	pathophysiological	pathophysiological	ADJ
h989r210w6s	7	12	gradients	gradient	NOUN
h989r210w6s	7	13	that	that	PRON
h989r210w6s	7	14	are	be	AUX
h989r210w6s	7	15	more	more	ADV
h989r210w6s	7	16	complex	complex	ADJ
h989r210w6s	7	17	than	than	ADP
h989r210w6s	7	18	conventional	conventional	ADJ
h989r210w6s	7	19	two	two	NUM
h989r210w6s	7	20	-	-	PUNCT
h989r210w6s	7	21	dimensional	dimensional	ADJ
h989r210w6s	7	22	cell	cell	NOUN
h989r210w6s	7	23	cultures	culture	NOUN
h989r210w6s	7	24	in	in	ADP
h989r210w6s	7	25	addition	addition	NOUN
h989r210w6s	7	26	to	to	ADP
h989r210w6s	7	27	being	be	AUX
h989r210w6s	7	28	higher	high	ADJ
h989r210w6s	7	29	throughput	throughput	NOUN
h989r210w6s	7	30	than	than	SCONJ
h989r210w6s	7	31	animal	animal	NOUN
h989r210w6s	7	32	models.the	models.the	DET
h989r210w6s	7	33	main	main	ADJ
h989r210w6s	7	34	focus	focus	NOUN
h989r210w6s	7	35	of	of	ADP
h989r210w6s	7	36	this	this	DET
h989r210w6s	7	37	work	work	NOUN
h989r210w6s	7	38	is	be	AUX
h989r210w6s	7	39	liposomal	liposomal	ADJ
h989r210w6s	7	40	drug	drug	NOUN
h989r210w6s	7	41	carrier	carrier	NOUN
h989r210w6s	7	42	distribution	distribution	NOUN
h989r210w6s	7	43	within	within	ADP
h989r210w6s	7	44	tumor	tumor	NOUN
h989r210w6s	7	45	spheroids	spheroid	NOUN
h989r210w6s	7	46	.	.	PUNCT
h989r210w6s	8	1	these	these	DET
h989r210w6s	8	2	nano	nano	NOUN
h989r210w6s	8	3	-	-	PUNCT
h989r210w6s	8	4	carriers	carrier	NOUN
h989r210w6s	8	5	have	have	VERB
h989r210w6s	8	6	the	the	DET
h989r210w6s	8	7	ability	ability	NOUN
h989r210w6s	8	8	to	to	PART
h989r210w6s	8	9	positively	positively	ADV
h989r210w6s	8	10	alter	alter	VERB
h989r210w6s	8	11	pharmacokinetics	pharmacokinetic	NOUN
h989r210w6s	8	12	profiles	profile	NOUN
h989r210w6s	8	13	and	and	CCONJ
h989r210w6s	8	14	have	have	VERB
h989r210w6s	8	15	the	the	DET
h989r210w6s	8	16	capability	capability	NOUN
h989r210w6s	8	17	for	for	ADP
h989r210w6s	8	18	encapsulation	encapsulation	NOUN
h989r210w6s	8	19	of	of	ADP
h989r210w6s	8	20	therapeutics	therapeutic	NOUN
h989r210w6s	8	21	.	.	PUNCT
h989r210w6s	9	1	doxorubicin	doxorubicin	PROPN
h989r210w6s	9	2	was	be	AUX
h989r210w6s	9	3	the	the	DET
h989r210w6s	9	4	chemotherapeutic	chemotherapeutic	NOUN
h989r210w6s	9	5	utilized	utilize	VERB
h989r210w6s	9	6	in	in	ADP
h989r210w6s	9	7	this	this	DET
h989r210w6s	9	8	work	work	NOUN
h989r210w6s	9	9	due	due	ADP
h989r210w6s	9	10	to	to	ADP
h989r210w6s	9	11	its	its	PRON
h989r210w6s	9	12	native	native	ADJ
h989r210w6s	9	13	fluorescent	fluorescent	NOUN
h989r210w6s	9	14	properties	property	NOUN
h989r210w6s	9	15	as	as	ADV
h989r210w6s	9	16	well	well	ADV
h989r210w6s	9	17	as	as	ADP
h989r210w6s	9	18	its	its	PRON
h989r210w6s	9	19	ability	ability	NOUN
h989r210w6s	9	20	to	to	PART
h989r210w6s	9	21	be	be	AUX
h989r210w6s	9	22	detected	detect	VERB
h989r210w6s	9	23	using	use	VERB
h989r210w6s	9	24	mass	mass	NOUN
h989r210w6s	9	25	spectrometry	spectrometry	NOUN
h989r210w6s	9	26	.	.	PUNCT
h989r210w6s	10	1	the	the	DET
h989r210w6s	10	2	work	work	NOUN
h989r210w6s	10	3	described	describe	VERB
h989r210w6s	10	4	herein	herein	ADV
h989r210w6s	10	5	develops	develop	VERB
h989r210w6s	10	6	a	a	DET
h989r210w6s	10	7	new	new	ADJ
h989r210w6s	10	8	platform	platform	NOUN
h989r210w6s	10	9	that	that	PRON
h989r210w6s	10	10	can	can	AUX
h989r210w6s	10	11	readily	readily	ADV
h989r210w6s	10	12	be	be	AUX
h989r210w6s	10	13	analyzed	analyze	VERB
h989r210w6s	10	14	using	use	VERB
h989r210w6s	10	15	maldi	maldi	PROPN
h989r210w6s	10	16	msi	msi	PROPN
h989r210w6s	10	17	,	,	PUNCT
h989r210w6s	10	18	something	something	PRON
h989r210w6s	10	19	that	that	PRON
h989r210w6s	10	20	has	have	AUX
h989r210w6s	10	21	not	not	PART
h989r210w6s	10	22	previously	previously	ADV
h989r210w6s	10	23	been	be	AUX
h989r210w6s	10	24	done	do	VERB
h989r210w6s	10	25	.	.	PUNCT
h989r210w6s	11	1	additional	additional	ADJ
h989r210w6s	11	2	work	work	NOUN
h989r210w6s	11	3	presented	present	VERB
h989r210w6s	11	4	herein	herein	ADV
h989r210w6s	11	5	describes	describe	VERB
h989r210w6s	11	6	a	a	DET
h989r210w6s	11	7	silac	silac	PROPN
h989r210w6s	11	8	labeling	labeling	NOUN
h989r210w6s	11	9	approach	approach	NOUN
h989r210w6s	11	10	that	that	PRON
h989r210w6s	11	11	creates	create	VERB
h989r210w6s	11	12	a	a	DET
h989r210w6s	11	13	"	"	PUNCT
h989r210w6s	11	14	zip	zip	NOUN
h989r210w6s	11	15	code	code	NOUN
h989r210w6s	11	16	"	"	PUNCT
h989r210w6s	11	17	system	system	NOUN
h989r210w6s	11	18	for	for	ADP
h989r210w6s	11	19	proteins	protein	NOUN
h989r210w6s	11	20	residing	reside	VERB
h989r210w6s	11	21	in	in	ADP
h989r210w6s	11	22	the	the	DET
h989r210w6s	11	23	various	various	ADJ
h989r210w6s	11	24	cellular	cellular	ADJ
h989r210w6s	11	25	populations	population	NOUN
h989r210w6s	11	26	of	of	ADP
h989r210w6s	11	27	a	a	DET
h989r210w6s	11	28	tumor	tumor	NOUN
h989r210w6s	11	29	spheroid.all	spheroid.all	NOUN
h989r210w6s	11	30	together	together	ADV
h989r210w6s	11	31	this	this	DET
h989r210w6s	11	32	work	work	NOUN
h989r210w6s	11	33	focuses	focus	VERB
h989r210w6s	11	34	on	on	ADP
h989r210w6s	11	35	the	the	DET
h989r210w6s	11	36	spatial	spatial	ADJ
h989r210w6s	11	37	localizations	localization	NOUN
h989r210w6s	11	38	of	of	ADP
h989r210w6s	11	39	endogenous	endogenous	ADJ
h989r210w6s	11	40	and	and	CCONJ
h989r210w6s	11	41	exogenous	exogenous	ADJ
h989r210w6s	11	42	molecules	molecule	NOUN
h989r210w6s	11	43	within	within	ADP
h989r210w6s	11	44	tumor	tumor	NOUN
h989r210w6s	11	45	spheroids	spheroid	NOUN
h989r210w6s	11	46	.	.	PUNCT