id	sid	tid	token	lemma	pos
h702q527g2c	1	1	proper	proper	ADJ
h702q527g2c	1	2	cell	cell	NOUN
h702q527g2c	1	3	function	function	NOUN
h702q527g2c	1	4	and	and	CCONJ
h702q527g2c	1	5	thus	thus	ADV
h702q527g2c	1	6	all	all	DET
h702q527g2c	1	7	life	life	NOUN
h702q527g2c	1	8	processes	process	NOUN
h702q527g2c	1	9	depend	depend	VERB
h702q527g2c	1	10	on	on	ADP
h702q527g2c	1	11	proteins	protein	NOUN
h702q527g2c	1	12	,	,	PUNCT
h702q527g2c	1	13	which	which	PRON
h702q527g2c	1	14	must	must	AUX
h702q527g2c	1	15	adopt	adopt	VERB
h702q527g2c	1	16	specific	specific	ADJ
h702q527g2c	1	17	conformations	conformation	NOUN
h702q527g2c	1	18	at	at	ADP
h702q527g2c	1	19	the	the	DET
h702q527g2c	1	20	right	right	ADJ
h702q527g2c	1	21	time	time	NOUN
h702q527g2c	1	22	and	and	CCONJ
h702q527g2c	1	23	place	place	NOUN
h702q527g2c	1	24	in	in	ADP
h702q527g2c	1	25	order	order	NOUN
h702q527g2c	1	26	to	to	PART
h702q527g2c	1	27	be	be	AUX
h702q527g2c	1	28	functional	functional	ADJ
h702q527g2c	1	29	.	.	PUNCT
h702q527g2c	2	1	all	all	DET
h702q527g2c	2	2	proteins	protein	NOUN
h702q527g2c	2	3	start	start	VERB
h702q527g2c	2	4	their	their	PRON
h702q527g2c	2	5	journey	journey	NOUN
h702q527g2c	2	6	being	be	AUX
h702q527g2c	2	7	synthesized	synthesize	VERB
h702q527g2c	2	8	by	by	ADP
h702q527g2c	2	9	the	the	DET
h702q527g2c	2	10	ribosome	ribosome	NOUN
h702q527g2c	2	11	as	as	ADP
h702q527g2c	2	12	a	a	DET
h702q527g2c	2	13	linear	linear	ADJ
h702q527g2c	2	14	polymer	polymer	NOUN
h702q527g2c	2	15	of	of	ADP
h702q527g2c	2	16	amino	amino	NOUN
h702q527g2c	2	17	acids	acid	NOUN
h702q527g2c	2	18	and	and	CCONJ
h702q527g2c	2	19	must	must	AUX
h702q527g2c	2	20	make	make	VERB
h702q527g2c	2	21	a	a	DET
h702q527g2c	2	22	transition	transition	NOUN
h702q527g2c	2	23	from	from	ADP
h702q527g2c	2	24	a	a	DET
h702q527g2c	2	25	disordered	disordered	NOUN
h702q527g2c	2	26	,	,	PUNCT
h702q527g2c	2	27	unfolded	unfold	VERB
h702q527g2c	2	28	ensemble	ensemble	NOUN
h702q527g2c	2	29	to	to	ADP
h702q527g2c	2	30	a	a	DET
h702q527g2c	2	31	functional	functional	ADJ
h702q527g2c	2	32	folded	fold	VERB
h702q527g2c	2	33	structure	structure	NOUN
h702q527g2c	2	34	.	.	PUNCT
h702q527g2c	3	1	the	the	DET
h702q527g2c	3	2	transition	transition	NOUN
h702q527g2c	3	3	can	can	AUX
h702q527g2c	3	4	occur	occur	VERB
h702q527g2c	3	5	during	during	ADP
h702q527g2c	3	6	synthesis	synthesis	NOUN
h702q527g2c	3	7	(	(	PUNCT
h702q527g2c	3	8	co	co	ADJ
h702q527g2c	3	9	-	-	ADJ
h702q527g2c	3	10	translational	translational	ADJ
h702q527g2c	3	11	folding	folding	NOUN
h702q527g2c	3	12	)	)	PUNCT
h702q527g2c	3	13	,	,	PUNCT
h702q527g2c	3	14	or	or	CCONJ
h702q527g2c	3	15	later	later	ADV
h702q527g2c	3	16	in	in	ADP
h702q527g2c	3	17	the	the	DET
h702q527g2c	3	18	protein	protein	NOUN
h702q527g2c	3	19	's	's	PART
h702q527g2c	3	20	lifetime	lifetime	NOUN
h702q527g2c	3	21	(	(	PUNCT
h702q527g2c	3	22	intrinsically	intrinsically	ADV
h702q527g2c	3	23	disordered	disorder	VERB
h702q527g2c	3	24	proteins	protein	NOUN
h702q527g2c	3	25	or	or	CCONJ
h702q527g2c	3	26	idps	idps	NOUN
h702q527g2c	3	27	)	)	PUNCT
h702q527g2c	3	28	.	.	PUNCT
h702q527g2c	4	1	the	the	DET
h702q527g2c	4	2	thermodynamic	thermodynamic	ADJ
h702q527g2c	4	3	hypothesis	hypothesis	NOUN
h702q527g2c	4	4	of	of	ADP
h702q527g2c	4	5	protein	protein	NOUN
h702q527g2c	4	6	folding	fold	VERB
h702q527g2c	4	7	originally	originally	ADV
h702q527g2c	4	8	introduced	introduce	VERB
h702q527g2c	4	9	by	by	ADP
h702q527g2c	4	10	christian	christian	PROPN
h702q527g2c	4	11	b.	b.	PROPN
h702q527g2c	4	12	anfinsen	anfinsen	PROPN
h702q527g2c	4	13	states	state	VERB
h702q527g2c	4	14	that	that	SCONJ
h702q527g2c	4	15	the	the	DET
h702q527g2c	4	16	protein	protein	NOUN
h702q527g2c	4	17	native	native	ADJ
h702q527g2c	4	18	state	state	NOUN
h702q527g2c	4	19	is	be	AUX
h702q527g2c	4	20	the	the	DET
h702q527g2c	4	21	global	global	ADJ
h702q527g2c	4	22	energy	energy	NOUN
h702q527g2c	4	23	minimum	minimum	NOUN
h702q527g2c	4	24	of	of	ADP
h702q527g2c	4	25	a	a	DET
h702q527g2c	4	26	polypeptide	polypeptide	NOUN
h702q527g2c	4	27	.	.	PUNCT
h702q527g2c	5	1	this	this	DET
h702q527g2c	5	2	view	view	NOUN
h702q527g2c	5	3	is	be	AUX
h702q527g2c	5	4	consistent	consistent	ADJ
h702q527g2c	5	5	with	with	ADP
h702q527g2c	5	6	the	the	DET
h702q527g2c	5	7	behavior	behavior	NOUN
h702q527g2c	5	8	observed	observe	VERB
h702q527g2c	5	9	for	for	ADP
h702q527g2c	5	10	many	many	ADJ
h702q527g2c	5	11	small	small	ADJ
h702q527g2c	5	12	,	,	PUNCT
h702q527g2c	5	13	simple	simple	ADJ
h702q527g2c	5	14	protein	protein	NOUN
h702q527g2c	5	15	structures	structure	NOUN
h702q527g2c	5	16	,	,	PUNCT
h702q527g2c	5	17	but	but	CCONJ
h702q527g2c	5	18	is	be	AUX
h702q527g2c	5	19	not	not	PART
h702q527g2c	5	20	sufficient	sufficient	ADJ
h702q527g2c	5	21	to	to	PART
h702q527g2c	5	22	explain	explain	VERB
h702q527g2c	5	23	the	the	DET
h702q527g2c	5	24	observation	observation	NOUN
h702q527g2c	5	25	that	that	SCONJ
h702q527g2c	5	26	most	most	ADJ
h702q527g2c	5	27	proteins	protein	NOUN
h702q527g2c	5	28	misfold	misfold	ADJ
h702q527g2c	5	29	and	and	CCONJ
h702q527g2c	5	30	aggregate	aggregate	ADJ
h702q527g2c	5	31	during	during	ADP
h702q527g2c	5	32	classic	classic	ADJ
h702q527g2c	5	33	test	test	NOUN
h702q527g2c	5	34	tube	tube	NOUN
h702q527g2c	5	35	refolding	refolding	NOUN
h702q527g2c	5	36	experiments	experiment	NOUN
h702q527g2c	5	37	.	.	PUNCT
h702q527g2c	6	1	in	in	ADP
h702q527g2c	6	2	order	order	NOUN
h702q527g2c	6	3	to	to	PART
h702q527g2c	6	4	natively	natively	ADV
h702q527g2c	6	5	fold	fold	VERB
h702q527g2c	6	6	and	and	CCONJ
h702q527g2c	6	7	avoid	avoid	VERB
h702q527g2c	6	8	intermediates	intermediate	NOUN
h702q527g2c	6	9	that	that	PRON
h702q527g2c	6	10	may	may	AUX
h702q527g2c	6	11	lead	lead	VERB
h702q527g2c	6	12	to	to	ADP
h702q527g2c	6	13	misfolding	misfolding	NOUN
h702q527g2c	6	14	and	and	CCONJ
h702q527g2c	6	15	aggregation	aggregation	NOUN
h702q527g2c	6	16	,	,	PUNCT
h702q527g2c	6	17	many	many	ADJ
h702q527g2c	6	18	proteins	protein	NOUN
h702q527g2c	6	19	must	must	AUX
h702q527g2c	6	20	fold	fold	VERB
h702q527g2c	6	21	under	under	ADP
h702q527g2c	6	22	kinetic	kinetic	ADJ
h702q527g2c	6	23	control	control	NOUN
h702q527g2c	6	24	.	.	PUNCT
h702q527g2c	7	1	in	in	ADP
h702q527g2c	7	2	this	this	DET
h702q527g2c	7	3	work	work	NOUN
h702q527g2c	7	4	i	i	PRON
h702q527g2c	7	5	propose	propose	VERB
h702q527g2c	7	6	that	that	SCONJ
h702q527g2c	7	7	biases	bias	NOUN
h702q527g2c	7	8	in	in	ADP
h702q527g2c	7	9	the	the	DET
h702q527g2c	7	10	unfolded	unfolded	ADJ
h702q527g2c	7	11	ensemble	ensemble	ADJ
h702q527g2c	7	12	and	and	CCONJ
h702q527g2c	7	13	vectorial	vectorial	ADJ
h702q527g2c	7	14	appearance	appearance	NOUN
h702q527g2c	7	15	of	of	ADP
h702q527g2c	7	16	the	the	DET
h702q527g2c	7	17	polypeptide	polypeptide	NOUN
h702q527g2c	7	18	during	during	ADP
h702q527g2c	7	19	translation	translation	NOUN
h702q527g2c	7	20	(	(	PUNCT
h702q527g2c	7	21	or	or	CCONJ
h702q527g2c	7	22	analogously	analogously	ADV
h702q527g2c	7	23	the	the	DET
h702q527g2c	7	24	vectorial	vectorial	ADJ
h702q527g2c	7	25	appearance	appearance	NOUN
h702q527g2c	7	26	a	a	DET
h702q527g2c	7	27	polypeptide	polypeptide	NOUN
h702q527g2c	7	28	may	may	AUX
h702q527g2c	7	29	experiences	experience	NOUN
h702q527g2c	7	30	as	as	SCONJ
h702q527g2c	7	31	it	it	PRON
h702q527g2c	7	32	crosses	cross	VERB
h702q527g2c	7	33	a	a	DET
h702q527g2c	7	34	membrane	membrane	NOUN
h702q527g2c	7	35	)	)	PUNCT
h702q527g2c	7	36	are	be	AUX
h702q527g2c	7	37	tools	tool	NOUN
h702q527g2c	7	38	used	use	VERB
h702q527g2c	7	39	by	by	ADP
h702q527g2c	7	40	the	the	DET
h702q527g2c	7	41	cell	cell	NOUN
h702q527g2c	7	42	to	to	PART
h702q527g2c	7	43	gain	gain	VERB
h702q527g2c	7	44	kinetic	kinetic	ADJ
h702q527g2c	7	45	control	control	NOUN
h702q527g2c	7	46	of	of	ADP
h702q527g2c	7	47	the	the	DET
h702q527g2c	7	48	protein	protein	NOUN
h702q527g2c	7	49	folding	fold	VERB
h702q527g2c	7	50	pathway	pathway	NOUN
h702q527g2c	7	51	.	.	PUNCT
h702q527g2c	8	1	while	while	SCONJ
h702q527g2c	8	2	generally	generally	ADV
h702q527g2c	8	3	appreciated	appreciate	VERB
h702q527g2c	8	4	that	that	SCONJ
h702q527g2c	8	5	the	the	DET
h702q527g2c	8	6	unfolded	unfolded	ADJ
h702q527g2c	8	7	state	state	NOUN
h702q527g2c	8	8	is	be	AUX
h702q527g2c	8	9	a	a	DET
h702q527g2c	8	10	highly	highly	ADV
h702q527g2c	8	11	dynamic	dynamic	ADJ
h702q527g2c	8	12	ensemble	ensemble	NOUN
h702q527g2c	8	13	of	of	ADP
h702q527g2c	8	14	rapidly	rapidly	ADV
h702q527g2c	8	15	interconverting	interconverting	ADJ
h702q527g2c	8	16	conformations	conformation	NOUN
h702q527g2c	8	17	,	,	PUNCT
h702q527g2c	8	18	the	the	DET
h702q527g2c	8	19	conformational	conformational	ADJ
h702q527g2c	8	20	biases	bias	NOUN
h702q527g2c	8	21	and	and	CCONJ
h702q527g2c	8	22	how	how	SCONJ
h702q527g2c	8	23	the	the	DET
h702q527g2c	8	24	sequence	sequence	NOUN
h702q527g2c	8	25	of	of	ADP
h702q527g2c	8	26	amino	amino	NOUN
h702q527g2c	8	27	acids	acid	NOUN
h702q527g2c	8	28	shapes	shape	VERB
h702q527g2c	8	29	the	the	DET
h702q527g2c	8	30	ensemble	ensemble	NOUN
h702q527g2c	8	31	is	be	AUX
h702q527g2c	8	32	poorly	poorly	ADV
h702q527g2c	8	33	understood	understand	VERB
h702q527g2c	8	34	.	.	PUNCT
h702q527g2c	9	1	using	use	VERB
h702q527g2c	9	2	new	new	ADJ
h702q527g2c	9	3	analysis	analysis	NOUN
h702q527g2c	9	4	tools	tool	NOUN
h702q527g2c	9	5	and	and	CCONJ
h702q527g2c	9	6	a	a	DET
h702q527g2c	9	7	large	large	ADJ
h702q527g2c	9	8	,	,	PUNCT
h702q527g2c	9	9	hydrophobic	hydrophobic	NOUN
h702q527g2c	9	10	idp	idp	PROPN
h702q527g2c	9	11	i	i	PRON
h702q527g2c	9	12	show	show	VERB
h702q527g2c	9	13	that	that	SCONJ
h702q527g2c	9	14	the	the	DET
h702q527g2c	9	15	patterning	patterning	NOUN
h702q527g2c	9	16	of	of	ADP
h702q527g2c	9	17	hydrophobic	hydrophobic	NOUN
h702q527g2c	9	18	or	or	CCONJ
h702q527g2c	9	19	charged	charge	VERB
h702q527g2c	9	20	amino	amino	ADJ
h702q527g2c	9	21	acids	acid	NOUN
h702q527g2c	9	22	govern	govern	VERB
h702q527g2c	9	23	the	the	DET
h702q527g2c	9	24	intramolecular	intramolecular	ADJ
h702q527g2c	9	25	polypeptide	polypeptide	NOUN
h702q527g2c	9	26	behavior	behavior	NOUN
h702q527g2c	9	27	.	.	PUNCT
h702q527g2c	10	1	i	i	PRON
h702q527g2c	10	2	develop	develop	VERB
h702q527g2c	10	3	a	a	DET
h702q527g2c	10	4	novel	novel	NOUN
h702q527g2c	10	5	refolding	refolding	NOUN
h702q527g2c	10	6	assay	assay	NOUN
h702q527g2c	10	7	with	with	ADP
h702q527g2c	10	8	a	a	DET
h702q527g2c	10	9	fluorescent	fluorescent	ADJ
h702q527g2c	10	10	protein	protein	NOUN
h702q527g2c	10	11	sensor	sensor	NOUN
h702q527g2c	10	12	to	to	PART
h702q527g2c	10	13	directly	directly	ADV
h702q527g2c	10	14	measure	measure	VERB
h702q527g2c	10	15	the	the	DET
h702q527g2c	10	16	effects	effect	NOUN
h702q527g2c	10	17	of	of	ADP
h702q527g2c	10	18	vectorial	vectorial	ADJ
h702q527g2c	10	19	polypeptide	polypeptide	NOUN
h702q527g2c	10	20	appearance	appearance	NOUN
h702q527g2c	10	21	on	on	ADP
h702q527g2c	10	22	protein	protein	NOUN
h702q527g2c	10	23	folding	fold	VERB
h702q527g2c	10	24	.	.	PUNCT
h702q527g2c	11	1	finally	finally	ADV
h702q527g2c	11	2	,	,	PUNCT
h702q527g2c	11	3	using	use	VERB
h702q527g2c	11	4	in	in	ADP
h702q527g2c	11	5	vivo	vivo	NOUN
h702q527g2c	11	6	and	and	CCONJ
h702q527g2c	11	7	in	in	ADP
h702q527g2c	11	8	vitro	vitro	X
h702q527g2c	11	9	approaches	approach	NOUN
h702q527g2c	11	10	,	,	PUNCT
h702q527g2c	11	11	both	both	CCONJ
h702q527g2c	11	12	the	the	DET
h702q527g2c	11	13	shape	shape	NOUN
h702q527g2c	11	14	of	of	ADP
h702q527g2c	11	15	the	the	DET
h702q527g2c	11	16	unfolded	unfolded	ADJ
h702q527g2c	11	17	ensemble	ensemble	ADJ
h702q527g2c	11	18	and	and	CCONJ
h702q527g2c	11	19	vectorial	vectorial	ADJ
h702q527g2c	11	20	appearance	appearance	NOUN
h702q527g2c	11	21	are	be	AUX
h702q527g2c	11	22	examined	examine	VERB
h702q527g2c	11	23	in	in	ADP
h702q527g2c	11	24	the	the	DET
h702q527g2c	11	25	context	context	NOUN
h702q527g2c	11	26	of	of	ADP
h702q527g2c	11	27	an	an	DET
h702q527g2c	11	28	autotransporter	autotransporter	PROPN
h702q527g2c	11	29	virulence	virulence	NOUN
h702q527g2c	11	30	protein	protein	NOUN
h702q527g2c	11	31	,	,	PUNCT
h702q527g2c	11	32	pertactin	pertactin	NOUN
h702q527g2c	11	33	.	.	PUNCT
h702q527g2c	12	1	i	i	PRON
h702q527g2c	12	2	propose	propose	VERB
h702q527g2c	12	3	that	that	SCONJ
h702q527g2c	12	4	expanded	expand	VERB
h702q527g2c	12	5	unfolded	unfolded	ADJ
h702q527g2c	12	6	ensemble	ensemble	NOUN
h702q527g2c	12	7	of	of	ADP
h702q527g2c	12	8	pertactin	pertactin	NOUN
h702q527g2c	12	9	serves	serve	VERB
h702q527g2c	12	10	a	a	DET
h702q527g2c	12	11	functional	functional	ADJ
h702q527g2c	12	12	role	role	NOUN
h702q527g2c	12	13	by	by	ADP
h702q527g2c	12	14	preventing	prevent	VERB
h702q527g2c	12	15	aggregation	aggregation	NOUN
h702q527g2c	12	16	and	and	CCONJ
h702q527g2c	12	17	promoting	promote	VERB
h702q527g2c	12	18	efficient	efficient	ADJ
h702q527g2c	12	19	secretion	secretion	NOUN
h702q527g2c	12	20	to	to	ADP
h702q527g2c	12	21	the	the	DET
h702q527g2c	12	22	cell	cell	NOUN
h702q527g2c	12	23	surface	surface	NOUN
h702q527g2c	12	24	.	.	PUNCT
h702q527g2c	13	1	the	the	DET
h702q527g2c	13	2	principles	principle	NOUN
h702q527g2c	13	3	discussed	discuss	VERB
h702q527g2c	13	4	in	in	ADP
h702q527g2c	13	5	this	this	DET
h702q527g2c	13	6	dissertation	dissertation	NOUN
h702q527g2c	13	7	are	be	AUX
h702q527g2c	13	8	universal	universal	ADJ
h702q527g2c	13	9	to	to	ADP
h702q527g2c	13	10	all	all	DET
h702q527g2c	13	11	proteins	protein	NOUN
h702q527g2c	13	12	,	,	PUNCT
h702q527g2c	13	13	and	and	CCONJ
h702q527g2c	13	14	can	can	AUX
h702q527g2c	13	15	be	be	AUX
h702q527g2c	13	16	applied	apply	VERB
h702q527g2c	13	17	to	to	ADP
h702q527g2c	13	18	various	various	ADJ
h702q527g2c	13	19	systems	system	NOUN
h702q527g2c	13	20	in	in	ADP
h702q527g2c	13	21	order	order	NOUN
h702q527g2c	13	22	to	to	PART
h702q527g2c	13	23	gain	gain	VERB
h702q527g2c	13	24	a	a	DET
h702q527g2c	13	25	better	well	ADJ
h702q527g2c	13	26	understanding	understanding	NOUN
h702q527g2c	13	27	of	of	ADP
h702q527g2c	13	28	protein	protein	NOUN
h702q527g2c	13	29	folding	folding	NOUN
h702q527g2c	13	30	and	and	CCONJ
h702q527g2c	13	31	the	the	DET
h702q527g2c	13	32	molecular	molecular	ADJ
h702q527g2c	13	33	basis	basis	NOUN
h702q527g2c	13	34	for	for	ADP
h702q527g2c	13	35	disease	disease	NOUN
h702q527g2c	13	36	.	.	PUNCT