id sid tid token lemma pos h702q526r3x 1 1 protein protein NOUN h702q526r3x 1 2 sequences sequence NOUN h702q526r3x 1 3 have have AUX h702q526r3x 1 4 evolved evolve VERB h702q526r3x 1 5 to to PART h702q526r3x 1 6 fold fold VERB h702q526r3x 1 7 quickly quickly ADV h702q526r3x 1 8 and and CCONJ h702q526r3x 1 9 efficiently efficiently ADV h702q526r3x 1 10 to to ADP h702q526r3x 1 11 their their PRON h702q526r3x 1 12 native native ADJ h702q526r3x 1 13 , , PUNCT h702q526r3x 1 14 active active ADJ h702q526r3x 1 15 conformation conformation NOUN h702q526r3x 1 16 in in ADP h702q526r3x 1 17 the the DET h702q526r3x 1 18 complex complex ADJ h702q526r3x 1 19 crowded crowded ADJ h702q526r3x 1 20 environment environment NOUN h702q526r3x 1 21 of of ADP h702q526r3x 1 22 the the DET h702q526r3x 1 23 cell cell NOUN h702q526r3x 1 24 . . PUNCT h702q526r3x 2 1 a a DET h702q526r3x 2 2 role role NOUN h702q526r3x 2 3 for for ADP h702q526r3x 2 4 co co ADJ h702q526r3x 2 5 - - ADJ h702q526r3x 2 6 translational translational ADJ h702q526r3x 2 7 folding folding NOUN h702q526r3x 2 8 in in ADP h702q526r3x 2 9 efficient efficient ADJ h702q526r3x 2 10 protein protein NOUN h702q526r3x 2 11 folding folding NOUN h702q526r3x 2 12 has have AUX h702q526r3x 2 13 been be AUX h702q526r3x 2 14 proposed propose VERB h702q526r3x 2 15 . . PUNCT h702q526r3x 3 1 yet yet ADV h702q526r3x 3 2 , , PUNCT h702q526r3x 3 3 the the DET h702q526r3x 3 4 mechanisms mechanism NOUN h702q526r3x 3 5 by by ADP h702q526r3x 3 6 which which PRON h702q526r3x 3 7 co co NOUN h702q526r3x 3 8 - - ADJ h702q526r3x 3 9 translational translational ADJ h702q526r3x 3 10 folding folding NOUN h702q526r3x 3 11 might might AUX h702q526r3x 3 12 affect affect VERB h702q526r3x 3 13 protein protein NOUN h702q526r3x 3 14 folding fold VERB h702q526r3x 3 15 efficiency efficiency NOUN h702q526r3x 3 16 are be AUX h702q526r3x 3 17 not not PART h702q526r3x 3 18 completely completely ADV h702q526r3x 3 19 understood understand VERB h702q526r3x 3 20 , , PUNCT h702q526r3x 3 21 primarily primarily ADV h702q526r3x 3 22 because because SCONJ h702q526r3x 3 23 only only ADV h702q526r3x 3 24 a a DET h702q526r3x 3 25 small small ADJ h702q526r3x 3 26 number number NOUN h702q526r3x 3 27 of of ADP h702q526r3x 3 28 co co ADJ h702q526r3x 3 29 - - ADJ h702q526r3x 3 30 translational translational ADJ h702q526r3x 3 31 folding folding NOUN h702q526r3x 3 32 studies study NOUN h702q526r3x 3 33 have have AUX h702q526r3x 3 34 been be AUX h702q526r3x 3 35 performed perform VERB h702q526r3x 3 36 . . PUNCT h702q526r3x 4 1 the the DET h702q526r3x 4 2 current current ADJ h702q526r3x 4 3 study study NOUN h702q526r3x 4 4 describes describe VERB h702q526r3x 4 5 co co ADJ h702q526r3x 4 6 - - ADJ h702q526r3x 4 7 translational translational ADJ h702q526r3x 4 8 folding folding NOUN h702q526r3x 4 9 of of ADP h702q526r3x 4 10 green green ADJ h702q526r3x 4 11 fluorescent fluorescent NOUN h702q526r3x 4 12 protein protein NOUN h702q526r3x 4 13 ( ( PUNCT h702q526r3x 4 14 gfp gfp NOUN h702q526r3x 4 15 ) ) PUNCT h702q526r3x 4 16 , , PUNCT h702q526r3x 4 17 a a DET h702q526r3x 4 18 ìøå¢-sheet ìøå¢-sheet NOUN h702q526r3x 4 19 protein protein NOUN h702q526r3x 4 20 with with ADP h702q526r3x 4 21 complex complex ADJ h702q526r3x 4 22 native native ADJ h702q526r3x 4 23 topology topology NOUN h702q526r3x 4 24 . . PUNCT h702q526r3x 5 1 the the DET h702q526r3x 5 2 amino amino ADJ h702q526r3x 5 3 acid acid NOUN h702q526r3x 5 4 residues residue NOUN h702q526r3x 5 5 that that PRON h702q526r3x 5 6 make make VERB h702q526r3x 5 7 contacts contact NOUN h702q526r3x 5 8 in in ADP h702q526r3x 5 9 native native ADJ h702q526r3x 5 10 ìøå¢-sheet ìøå¢-sheet NOUN h702q526r3x 5 11 proteins protein NOUN h702q526r3x 5 12 are be AUX h702q526r3x 5 13 often often ADV h702q526r3x 5 14 far far ADV h702q526r3x 5 15 apart apart ADV h702q526r3x 5 16 in in ADP h702q526r3x 5 17 the the DET h702q526r3x 5 18 primary primary ADJ h702q526r3x 5 19 sequence sequence NOUN h702q526r3x 5 20 . . PUNCT h702q526r3x 6 1 formation formation NOUN h702q526r3x 6 2 of of ADP h702q526r3x 6 3 native native ADJ h702q526r3x 6 4 - - PUNCT h702q526r3x 6 5 like like ADJ h702q526r3x 6 6 contacts contact NOUN h702q526r3x 6 7 for for ADP h702q526r3x 6 8 n n ADJ h702q526r3x 6 9 - - PUNCT h702q526r3x 6 10 terminal terminal ADJ h702q526r3x 6 11 portions portion NOUN h702q526r3x 6 12 of of ADP h702q526r3x 6 13 such such ADJ h702q526r3x 6 14 polypeptides polypeptide NOUN h702q526r3x 6 15 will will AUX h702q526r3x 6 16 be be AUX h702q526r3x 6 17 delayed delay VERB h702q526r3x 6 18 during during ADP h702q526r3x 6 19 vectorial vectorial ADJ h702q526r3x 6 20 synthesis synthesis NOUN h702q526r3x 6 21 on on ADP h702q526r3x 6 22 the the DET h702q526r3x 6 23 ribosome ribosome NOUN h702q526r3x 6 24 , , PUNCT h702q526r3x 6 25 because because SCONJ h702q526r3x 6 26 the the DET h702q526r3x 6 27 c c X h702q526r3x 6 28 - - PUNCT h702q526r3x 6 29 terminal terminal ADJ h702q526r3x 6 30 contact contact NOUN h702q526r3x 6 31 residues residue NOUN h702q526r3x 6 32 have have AUX h702q526r3x 6 33 not not PART h702q526r3x 6 34 yet yet ADV h702q526r3x 6 35 been be AUX h702q526r3x 6 36 synthesized synthesize VERB h702q526r3x 6 37 , , PUNCT h702q526r3x 6 38 or or CCONJ h702q526r3x 6 39 are be AUX h702q526r3x 6 40 sterically sterically ADV h702q526r3x 6 41 inaccessible inaccessible ADJ h702q526r3x 6 42 in in ADP h702q526r3x 6 43 the the DET h702q526r3x 6 44 ribosome ribosome ADJ h702q526r3x 6 45 exit exit NOUN h702q526r3x 6 46 tunnel tunnel NOUN h702q526r3x 6 47 . . PUNCT h702q526r3x 7 1 the the DET h702q526r3x 7 2 degree degree NOUN h702q526r3x 7 3 of of ADP h702q526r3x 7 4 co co ADJ h702q526r3x 7 5 - - ADJ h702q526r3x 7 6 translational translational ADJ h702q526r3x 7 7 folding folding NOUN h702q526r3x 7 8 of of ADP h702q526r3x 7 9 these these DET h702q526r3x 7 10 n n ADJ h702q526r3x 7 11 - - PUNCT h702q526r3x 7 12 terminal terminal ADJ h702q526r3x 7 13 regions region NOUN h702q526r3x 7 14 , , PUNCT h702q526r3x 7 15 and and CCONJ h702q526r3x 7 16 the the DET h702q526r3x 7 17 overall overall ADJ h702q526r3x 7 18 ability ability NOUN h702q526r3x 7 19 of of ADP h702q526r3x 7 20 the the DET h702q526r3x 7 21 nascent nascent ADJ h702q526r3x 7 22 chain chain NOUN h702q526r3x 7 23 to to PART h702q526r3x 7 24 evade evade VERB h702q526r3x 7 25 erroneous erroneous ADJ h702q526r3x 7 26 conformation conformation NOUN h702q526r3x 7 27 after after ADP h702q526r3x 7 28 its its PRON h702q526r3x 7 29 complete complete ADJ h702q526r3x 7 30 synthesis synthesis NOUN h702q526r3x 7 31 , , PUNCT h702q526r3x 7 32 are be AUX h702q526r3x 7 33 still still ADV h702q526r3x 7 34 unknown unknown ADJ h702q526r3x 7 35 . . PUNCT h702q526r3x 8 1 studies study NOUN h702q526r3x 8 2 with with ADP h702q526r3x 8 3 ribosome ribosome ADJ h702q526r3x 8 4 - - PUNCT h702q526r3x 8 5 bound bind VERB h702q526r3x 8 6 gfp gfp NOUN h702q526r3x 8 7 showed show VERB h702q526r3x 8 8 that that SCONJ h702q526r3x 8 9 gfp gfp NOUN h702q526r3x 8 10 can can AUX h702q526r3x 8 11 fold fold VERB h702q526r3x 8 12 completely completely ADV h702q526r3x 8 13 to to ADP h702q526r3x 8 14 its its PRON h702q526r3x 8 15 native native ADJ h702q526r3x 8 16 structure structure NOUN h702q526r3x 8 17 on on ADP h702q526r3x 8 18 the the DET h702q526r3x 8 19 ribosomal ribosomal ADJ h702q526r3x 8 20 surface surface NOUN h702q526r3x 8 21 . . PUNCT h702q526r3x 9 1 however however ADV h702q526r3x 9 2 , , PUNCT h702q526r3x 9 3 complete complete ADJ h702q526r3x 9 4 folding folding NOUN h702q526r3x 9 5 is be AUX h702q526r3x 9 6 only only ADV h702q526r3x 9 7 possible possible ADJ h702q526r3x 9 8 if if SCONJ h702q526r3x 9 9 the the DET h702q526r3x 9 10 entire entire ADJ h702q526r3x 9 11 gfp gfp NOUN h702q526r3x 9 12 sequence sequence NOUN h702q526r3x 9 13 is be AUX h702q526r3x 9 14 exposed expose VERB h702q526r3x 9 15 outside outside ADP h702q526r3x 9 16 of of ADP h702q526r3x 9 17 the the DET h702q526r3x 9 18 ribosome ribosome ADJ h702q526r3x 9 19 exit exit NOUN h702q526r3x 9 20 tunnel tunnel NOUN h702q526r3x 9 21 . . PUNCT h702q526r3x 10 1 importantly importantly ADV h702q526r3x 10 2 , , PUNCT h702q526r3x 10 3 gfp gfp VERB h702q526r3x 10 4 nascent nascent ADJ h702q526r3x 10 5 chains chain NOUN h702q526r3x 10 6 that that PRON h702q526r3x 10 7 have have VERB h702q526r3x 10 8 their their PRON h702q526r3x 10 9 c c NOUN h702q526r3x 10 10 - - PUNCT h702q526r3x 10 11 terminus terminus NOUN h702q526r3x 10 12 buried bury VERB h702q526r3x 10 13 in in ADP h702q526r3x 10 14 the the DET h702q526r3x 10 15 ribosome ribosome ADJ h702q526r3x 10 16 exit exit NOUN h702q526r3x 10 17 tunnel tunnel NOUN h702q526r3x 10 18 remain remain VERB h702q526r3x 10 19 folding fold VERB h702q526r3x 10 20 competent competent ADJ h702q526r3x 10 21 and and CCONJ h702q526r3x 10 22 fold fold VERB h702q526r3x 10 23 to to ADP h702q526r3x 10 24 a a DET h702q526r3x 10 25 native native ADJ h702q526r3x 10 26 conformation conformation NOUN h702q526r3x 10 27 with with ADP h702q526r3x 10 28 high high ADJ h702q526r3x 10 29 efficiency efficiency NOUN h702q526r3x 10 30 after after ADP h702q526r3x 10 31 release release NOUN h702q526r3x 10 32 from from ADP h702q526r3x 10 33 the the DET h702q526r3x 10 34 ribosome ribosome NOUN h702q526r3x 10 35 ; ; PUNCT h702q526r3x 10 36 this this DET h702q526r3x 10 37 efficiency efficiency NOUN h702q526r3x 10 38 is be AUX h702q526r3x 10 39 significantly significantly ADV h702q526r3x 10 40 higher high ADJ h702q526r3x 10 41 than than ADP h702q526r3x 10 42 the the DET h702q526r3x 10 43 folding fold VERB h702q526r3x 10 44 efficiency efficiency NOUN h702q526r3x 10 45 of of ADP h702q526r3x 10 46 chemically chemically ADV h702q526r3x 10 47 denatured denature VERB h702q526r3x 10 48 gfp gfp NOUN h702q526r3x 10 49 . . PUNCT h702q526r3x 11 1 time time NOUN h702q526r3x 11 2 resolved resolve VERB h702q526r3x 11 3 anisotropy anisotropy NOUN h702q526r3x 11 4 measurements measurement NOUN h702q526r3x 11 5 revealed reveal VERB h702q526r3x 11 6 low low ADJ h702q526r3x 11 7 conformational conformational ADJ h702q526r3x 11 8 flexibility flexibility NOUN h702q526r3x 11 9 for for ADP h702q526r3x 11 10 the the DET h702q526r3x 11 11 gfp gfp NOUN h702q526r3x 11 12 nascent nascent ADJ h702q526r3x 11 13 chains chain NOUN h702q526r3x 11 14 with with ADP h702q526r3x 11 15 c c NOUN h702q526r3x 11 16 - - PUNCT h702q526r3x 11 17 terminus terminus NOUN h702q526r3x 11 18 in in ADP h702q526r3x 11 19 the the DET h702q526r3x 11 20 ribosome ribosome ADJ h702q526r3x 11 21 exit exit NOUN h702q526r3x 11 22 tunnel tunnel NOUN h702q526r3x 11 23 . . PUNCT h702q526r3x 12 1 similar similar ADJ h702q526r3x 12 2 low low ADJ h702q526r3x 12 3 conformational conformational ADJ h702q526r3x 12 4 flexibility flexibility NOUN h702q526r3x 12 5 was be AUX h702q526r3x 12 6 determined determine VERB h702q526r3x 12 7 and and CCONJ h702q526r3x 12 8 for for ADP h702q526r3x 12 9 completely completely ADV h702q526r3x 12 10 folded fold VERB h702q526r3x 12 11 ribosome ribosome NOUN h702q526r3x 12 12 - - PUNCT h702q526r3x 12 13 bound bind VERB h702q526r3x 12 14 gfp gfp NOUN h702q526r3x 12 15 chains chain NOUN h702q526r3x 12 16 , , PUNCT h702q526r3x 12 17 but but CCONJ h702q526r3x 12 18 not not PART h702q526r3x 12 19 for for ADP h702q526r3x 12 20 truncated truncate VERB h702q526r3x 12 21 ribosome ribosome NOUN h702q526r3x 12 22 - - PUNCT h702q526r3x 12 23 bound bind VERB h702q526r3x 12 24 gfp gfp NOUN h702q526r3x 12 25 chains chain NOUN h702q526r3x 12 26 . . PUNCT h702q526r3x 13 1 in in ADP h702q526r3x 13 2 addition addition NOUN h702q526r3x 13 3 , , PUNCT h702q526r3x 13 4 a a DET h702q526r3x 13 5 protease protease NOUN h702q526r3x 13 6 resistance resistance NOUN h702q526r3x 13 7 assay assay PROPN h702q526r3x 13 8 revealed reveal VERB h702q526r3x 13 9 the the DET h702q526r3x 13 10 presence presence NOUN h702q526r3x 13 11 of of ADP h702q526r3x 13 12 a a DET h702q526r3x 13 13 stable stable ADJ h702q526r3x 13 14 gfp gfp NOUN h702q526r3x 13 15 nascent nascent ADJ h702q526r3x 13 16 chain chain NOUN h702q526r3x 13 17 fragment fragment NOUN h702q526r3x 13 18 with with ADP h702q526r3x 13 19 a a DET h702q526r3x 13 20 size size NOUN h702q526r3x 13 21 close close ADJ h702q526r3x 13 22 to to ADP h702q526r3x 13 23 the the DET h702q526r3x 13 24 size size NOUN h702q526r3x 13 25 of of ADP h702q526r3x 13 26 full full ADJ h702q526r3x 13 27 length length NOUN h702q526r3x 13 28 gfp.these gfp.these ADJ h702q526r3x 13 29 results result NOUN h702q526r3x 13 30 suggest suggest VERB h702q526r3x 13 31 that that SCONJ h702q526r3x 13 32 co co ADJ h702q526r3x 13 33 - - ADJ h702q526r3x 13 34 translational translational ADJ h702q526r3x 13 35 folding folding NOUN h702q526r3x 13 36 promotes promote VERB h702q526r3x 13 37 the the DET h702q526r3x 13 38 acquisition acquisition NOUN h702q526r3x 13 39 of of ADP h702q526r3x 13 40 on on ADP h702q526r3x 13 41 pathway pathway NOUN h702q526r3x 13 42 , , PUNCT h702q526r3x 13 43 native native ADJ h702q526r3x 13 44 - - PUNCT h702q526r3x 13 45 like like ADJ h702q526r3x 13 46 conformations conformation NOUN h702q526r3x 13 47 of of ADP h702q526r3x 13 48 the the DET h702q526r3x 13 49 growing grow VERB h702q526r3x 13 50 gfp gfp NOUN h702q526r3x 13 51 nascent nascent ADJ h702q526r3x 13 52 chains chain NOUN h702q526r3x 13 53 , , PUNCT h702q526r3x 13 54 resulting result VERB h702q526r3x 13 55 in in ADP h702q526r3x 13 56 high high ADJ h702q526r3x 13 57 folding fold VERB h702q526r3x 13 58 efficiency efficiency NOUN h702q526r3x 13 59 for for ADP h702q526r3x 13 60 an an DET h702q526r3x 13 61 otherwise otherwise ADV h702q526r3x 13 62 highly highly ADV h702q526r3x 13 63 aggregation aggregation NOUN h702q526r3x 13 64 - - PUNCT h702q526r3x 13 65 prone prone ADJ h702q526r3x 13 66 ì_å_-sheet ì_å_-sheet PROPN h702q526r3x 13 67 protein protein NOUN h702q526r3x 13 68 . . PUNCT