id sid tid token lemma pos h415p843h7j 1 1 squaraine squaraine ADJ h415p843h7j 1 2 dyes dye NOUN h415p843h7j 1 3 are be AUX h415p843h7j 1 4 intensely intensely ADV h415p843h7j 1 5 colored color VERB h415p843h7j 1 6 fluorescent fluorescent NOUN h415p843h7j 1 7 dyes dye NOUN h415p843h7j 1 8 that that PRON h415p843h7j 1 9 absorb absorb VERB h415p843h7j 1 10 and and CCONJ h415p843h7j 1 11 emit emit VERB h415p843h7j 1 12 in in ADP h415p843h7j 1 13 the the DET h415p843h7j 1 14 red red NOUN h415p843h7j 1 15 and and CCONJ h415p843h7j 1 16 near near ADP h415p843h7j 1 17 infrared infrared ADJ h415p843h7j 1 18 wavelengths wavelength NOUN h415p843h7j 1 19 which which PRON h415p843h7j 1 20 are be AUX h415p843h7j 1 21 valuable valuable ADJ h415p843h7j 1 22 wavelength wavelength NOUN h415p843h7j 1 23 regions region NOUN h415p843h7j 1 24 for for ADP h415p843h7j 1 25 bioimaging bioimaging NOUN h415p843h7j 1 26 . . PUNCT h415p843h7j 2 1 however however ADV h415p843h7j 2 2 , , PUNCT h415p843h7j 2 3 squaraine squaraine ADJ h415p843h7j 2 4 dyes dye NOUN h415p843h7j 2 5 have have VERB h415p843h7j 2 6 tendency tendency NOUN h415p843h7j 2 7 to to PART h415p843h7j 2 8 form form VERB h415p843h7j 2 9 aggregates aggregate NOUN h415p843h7j 2 10 and and CCONJ h415p843h7j 2 11 they they PRON h415p843h7j 2 12 are be AUX h415p843h7j 2 13 susceptible susceptible ADJ h415p843h7j 2 14 to to ADP h415p843h7j 2 15 nucleophilic nucleophilic ADJ h415p843h7j 2 16 attack attack NOUN h415p843h7j 2 17 . . PUNCT h415p843h7j 3 1 encapsulation encapsulation NOUN h415p843h7j 3 2 of of ADP h415p843h7j 3 3 a a DET h415p843h7j 3 4 squaraine squaraine ADJ h415p843h7j 3 5 dye dye NOUN h415p843h7j 3 6 inside inside ADP h415p843h7j 3 7 a a DET h415p843h7j 3 8 tetralactam tetralactam NOUN h415p843h7j 3 9 macrocycle macrocycle NOUN h415p843h7j 3 10 makes make VERB h415p843h7j 3 11 a a DET h415p843h7j 3 12 squaraine squaraine ADJ h415p843h7j 3 13 rotaxane rotaxane NOUN h415p843h7j 3 14 and and CCONJ h415p843h7j 3 15 avoids avoid VERB h415p843h7j 3 16 both both DET h415p843h7j 3 17 problems problem NOUN h415p843h7j 3 18 simultaneously simultaneously ADV h415p843h7j 3 19 while while SCONJ h415p843h7j 3 20 retaining retain VERB h415p843h7j 3 21 the the DET h415p843h7j 3 22 favorable favorable ADJ h415p843h7j 3 23 photophysical photophysical ADJ h415p843h7j 3 24 properties property NOUN h415p843h7j 3 25 of of ADP h415p843h7j 3 26 the the DET h415p843h7j 3 27 squaraine squaraine ADJ h415p843h7j 3 28 dye dye NOUN h415p843h7j 3 29 . . PUNCT h415p843h7j 4 1 this this DET h415p843h7j 4 2 dissertation dissertation NOUN h415p843h7j 4 3 describes describe VERB h415p843h7j 4 4 a a DET h415p843h7j 4 5 series series NOUN h415p843h7j 4 6 of of ADP h415p843h7j 4 7 structural structural ADJ h415p843h7j 4 8 investigations investigation NOUN h415p843h7j 4 9 of of ADP h415p843h7j 4 10 squaraine squaraine ADJ h415p843h7j 4 11 rotaxanes rotaxane NOUN h415p843h7j 4 12 and and CCONJ h415p843h7j 4 13 their their PRON h415p843h7j 4 14 fluorescent fluorescent NOUN h415p843h7j 4 15 properties property NOUN h415p843h7j 4 16 . . PUNCT h415p843h7j 5 1 rotaxanes rotaxane NOUN h415p843h7j 5 2 with with ADP h415p843h7j 5 3 structural structural ADJ h415p843h7j 5 4 variations variation NOUN h415p843h7j 5 5 in in ADP h415p843h7j 5 6 the the DET h415p843h7j 5 7 terminal terminal ADJ h415p843h7j 5 8 regions region NOUN h415p843h7j 5 9 of of ADP h415p843h7j 5 10 the the DET h415p843h7j 5 11 encapsulated encapsulate VERB h415p843h7j 5 12 squaraine squaraine ADJ h415p843h7j 5 13 thread thread NOUN h415p843h7j 5 14 were be AUX h415p843h7j 5 15 synthesized synthesize VERB h415p843h7j 5 16 and and CCONJ h415p843h7j 5 17 studied study VERB h415p843h7j 5 18 . . PUNCT h415p843h7j 6 1 they they PRON h415p843h7j 6 2 show show VERB h415p843h7j 6 3 high high ADJ h415p843h7j 6 4 stability stability NOUN h415p843h7j 6 5 in in ADP h415p843h7j 6 6 the the DET h415p843h7j 6 7 presence presence NOUN h415p843h7j 6 8 of of ADP h415p843h7j 6 9 nucleophiles nucleophile NOUN h415p843h7j 6 10 , , PUNCT h415p843h7j 6 11 and and CCONJ h415p843h7j 6 12 extreme extreme ADJ h415p843h7j 6 13 ph ph NOUN h415p843h7j 6 14 values value NOUN h415p843h7j 6 15 . . PUNCT h415p843h7j 7 1 introducing introduce VERB h415p843h7j 7 2 a a DET h415p843h7j 7 3 hydroxyl hydroxyl PROPN h415p843h7j 7 4 group group NOUN h415p843h7j 7 5 on on ADP h415p843h7j 7 6 the the DET h415p843h7j 7 7 anilinium anilinium NOUN h415p843h7j 7 8 ring ring NOUN h415p843h7j 7 9 of of ADP h415p843h7j 7 10 the the DET h415p843h7j 7 11 squaraine squaraine ADJ h415p843h7j 7 12 thread thread NOUN h415p843h7j 7 13 leads lead VERB h415p843h7j 7 14 to to ADP h415p843h7j 7 15 a a DET h415p843h7j 7 16 congested congested ADJ h415p843h7j 7 17 squaraine squaraine ADJ h415p843h7j 7 18 rotaxane rotaxane NOUN h415p843h7j 7 19 . . PUNCT h415p843h7j 8 1 dynamic dynamic ADJ h415p843h7j 8 2 nmr nmr PROPN h415p843h7j 8 3 studies study NOUN h415p843h7j 8 4 of of ADP h415p843h7j 8 5 this this DET h415p843h7j 8 6 rotaxane rotaxane NOUN h415p843h7j 8 7 allow allow VERB h415p843h7j 8 8 measurement measurement NOUN h415p843h7j 8 9 of of ADP h415p843h7j 8 10 the the DET h415p843h7j 8 11 hindered hinder VERB h415p843h7j 8 12 c c PROPN h415p843h7j 8 13 - - PUNCT h415p843h7j 8 14 n n NOUN h415p843h7j 8 15 bond bond NOUN h415p843h7j 8 16 rotation rotation NOUN h415p843h7j 8 17 in in ADP h415p843h7j 8 18 the the DET h415p843h7j 8 19 squaraine squaraine ADJ h415p843h7j 8 20 thread thread NOUN h415p843h7j 8 21 . . PUNCT h415p843h7j 9 1 the the DET h415p843h7j 9 2 rotaxane rotaxane NOUN h415p843h7j 9 3 mechanical mechanical ADJ h415p843h7j 9 4 stability stability NOUN h415p843h7j 9 5 also also ADV h415p843h7j 9 6 was be AUX h415p843h7j 9 7 found find VERB h415p843h7j 9 8 to to PART h415p843h7j 9 9 be be AUX h415p843h7j 9 10 affected affect VERB h415p843h7j 9 11 by by ADP h415p843h7j 9 12 the the DET h415p843h7j 9 13 macrocycle macrocycle NOUN h415p843h7j 9 14 structure structure NOUN h415p843h7j 9 15 . . PUNCT h415p843h7j 10 1 a a DET h415p843h7j 10 2 series series NOUN h415p843h7j 10 3 of of ADP h415p843h7j 10 4 squaraine squaraine ADJ h415p843h7j 10 5 rotaxanes rotaxane NOUN h415p843h7j 10 6 with with ADP h415p843h7j 10 7 a a DET h415p843h7j 10 8 pyridyl pyridyl NOUN h415p843h7j 10 9 - - PUNCT h415p843h7j 10 10 containing contain VERB h415p843h7j 10 11 macrocycle macrocycle NOUN h415p843h7j 10 12 adopt adopt VERB h415p843h7j 10 13 an an DET h415p843h7j 10 14 unusual unusual ADJ h415p843h7j 10 15 boat boat NOUN h415p843h7j 10 16 conformation conformation NOUN h415p843h7j 10 17 in in ADP h415p843h7j 10 18 the the DET h415p843h7j 10 19 solid solid ADJ h415p843h7j 10 20 state state NOUN h415p843h7j 10 21 . . PUNCT h415p843h7j 11 1 it it PRON h415p843h7j 11 2 was be AUX h415p843h7j 11 3 deduced deduce VERB h415p843h7j 11 4 that that SCONJ h415p843h7j 11 5 the the DET h415p843h7j 11 6 macrocycle macrocycle NOUN h415p843h7j 11 7 underwent undergo VERB h415p843h7j 11 8 a a DET h415p843h7j 11 9 very very ADV h415p843h7j 11 10 fast fast ADJ h415p843h7j 11 11 chair chair NOUN h415p843h7j 11 12 / / SYM h415p843h7j 11 13 boat boat NOUN h415p843h7j 11 14 conformational conformational ADJ h415p843h7j 11 15 exchange exchange NOUN h415p843h7j 11 16 in in ADP h415p843h7j 11 17 solution solution NOUN h415p843h7j 11 18 . . PUNCT h415p843h7j 12 1 the the DET h415p843h7j 12 2 photophysical photophysical ADJ h415p843h7j 12 3 properties property NOUN h415p843h7j 12 4 of of ADP h415p843h7j 12 5 squaraine squaraine ADJ h415p843h7j 12 6 rotaxanes rotaxane NOUN h415p843h7j 12 7 , , PUNCT h415p843h7j 12 8 especially especially ADV h415p843h7j 12 9 the the DET h415p843h7j 12 10 fluorescence fluorescence ADJ h415p843h7j 12 11 quantum quantum NOUN h415p843h7j 12 12 yield yield NOUN h415p843h7j 12 13 , , PUNCT h415p843h7j 12 14 are be AUX h415p843h7j 12 15 affected affect VERB h415p843h7j 12 16 by by ADP h415p843h7j 12 17 the the DET h415p843h7j 12 18 chair chair NOUN h415p843h7j 12 19 / / SYM h415p843h7j 12 20 boat boat NOUN h415p843h7j 12 21 conformational conformational ADJ h415p843h7j 12 22 exchange exchange NOUN h415p843h7j 12 23 of of ADP h415p843h7j 12 24 macrocycle macrocycle NOUN h415p843h7j 12 25 . . PUNCT h415p843h7j 13 1 a a DET h415p843h7j 13 2 truncated truncated ADJ h415p843h7j 13 3 squaraine squaraine ADJ h415p843h7j 13 4 rotaxane rotaxane NOUN h415p843h7j 13 5 was be AUX h415p843h7j 13 6 synthesized synthesize VERB h415p843h7j 13 7 and and CCONJ h415p843h7j 13 8 shown show VERB h415p843h7j 13 9 to to PART h415p843h7j 13 10 have have AUX h415p843h7j 13 11 enhanced enhance VERB h415p843h7j 13 12 fluorescence fluorescence NOUN h415p843h7j 13 13 . . PUNCT h415p843h7j 14 1 therefore therefore ADV h415p843h7j 14 2 , , PUNCT h415p843h7j 14 3 mechanical mechanical ADJ h415p843h7j 14 4 encapsulation encapsulation NOUN h415p843h7j 14 5 can can AUX h415p843h7j 14 6 be be AUX h415p843h7j 14 7 employed employ VERB h415p843h7j 14 8 as as ADP h415p843h7j 14 9 a a DET h415p843h7j 14 10 rational rational ADJ h415p843h7j 14 11 design design NOUN h415p843h7j 14 12 parameter parameter NOUN h415p843h7j 14 13 to to ADP h415p843h7j 14 14 fine fine ADJ h415p843h7j 14 15 tune tune VERB h415p843h7j 14 16 the the DET h415p843h7j 14 17 chemical chemical ADJ h415p843h7j 14 18 and and CCONJ h415p843h7j 14 19 photochemical photochemical ADJ h415p843h7j 14 20 properties property NOUN h415p843h7j 14 21 of of ADP h415p843h7j 14 22 squaraine squaraine ADJ h415p843h7j 14 23 dyes dye NOUN h415p843h7j 14 24 . . PUNCT h415p843h7j 15 1 in in ADP h415p843h7j 15 2 addition addition NOUN h415p843h7j 15 3 , , PUNCT h415p843h7j 15 4 bioconjugation bioconjugation NOUN h415p843h7j 15 5 methods method NOUN h415p843h7j 15 6 were be AUX h415p843h7j 15 7 developed develop VERB h415p843h7j 15 8 to to PART h415p843h7j 15 9 attach attach VERB h415p843h7j 15 10 the the DET h415p843h7j 15 11 squaraine squaraine ADJ h415p843h7j 15 12 rotaxanes rotaxane NOUN h415p843h7j 15 13 to to ADP h415p843h7j 15 14 targeting target VERB h415p843h7j 15 15 ligands ligand NOUN h415p843h7j 15 16 . . PUNCT h415p843h7j 16 1 a a DET h415p843h7j 16 2 zn zn PROPN h415p843h7j 16 3 - - PUNCT h415p843h7j 16 4 dpa dpa VERB h415p843h7j 16 5 conjugate conjugate NOUN h415p843h7j 16 6 could could AUX h415p843h7j 16 7 be be AUX h415p843h7j 16 8 used use VERB h415p843h7j 16 9 to to PART h415p843h7j 16 10 efficiently efficiently ADV h415p843h7j 16 11 label label VERB h415p843h7j 16 12 various various ADJ h415p843h7j 16 13 strains strain NOUN h415p843h7j 16 14 of of ADP h415p843h7j 16 15 bacteria bacteria NOUN h415p843h7j 16 16 . . PUNCT h415p843h7j 17 1 the the DET h415p843h7j 17 2 intense intense ADJ h415p843h7j 17 3 fluorescence fluorescence NOUN h415p843h7j 17 4 , , PUNCT h415p843h7j 17 5 photostability photostability NOUN h415p843h7j 17 6 , , PUNCT h415p843h7j 17 7 and and CCONJ h415p843h7j 17 8 specific specific ADJ h415p843h7j 17 9 interaction interaction NOUN h415p843h7j 17 10 allow allow VERB h415p843h7j 17 11 the the DET h415p843h7j 17 12 detection detection NOUN h415p843h7j 17 13 of of ADP h415p843h7j 17 14 the the DET h415p843h7j 17 15 bacteria bacteria NOUN h415p843h7j 17 16 infection infection NOUN h415p843h7j 17 17 in in ADP h415p843h7j 17 18 vitro vitro X h415p843h7j 17 19 and and CCONJ h415p843h7j 17 20 in in ADP h415p843h7j 17 21 vivo vivo PROPN h415p843h7j 17 22 . . PUNCT h415p843h7j 18 1 furthermore furthermore ADV h415p843h7j 18 2 , , PUNCT h415p843h7j 18 3 rotaxanes rotaxane NOUN h415p843h7j 18 4 were be AUX h415p843h7j 18 5 explored explore VERB h415p843h7j 18 6 to to ADP h415p843h7j 18 7 label label NOUN h415p843h7j 18 8 proteins protein NOUN h415p843h7j 18 9 in in ADP h415p843h7j 18 10 both both DET h415p843h7j 18 11 non non ADJ h415p843h7j 18 12 - - ADJ h415p843h7j 18 13 specific specific ADJ h415p843h7j 18 14 and and CCONJ h415p843h7j 18 15 specific specific ADJ h415p843h7j 18 16 manners manner NOUN h415p843h7j 18 17 . . PUNCT h415p843h7j 19 1 compared compare VERB h415p843h7j 19 2 to to ADP h415p843h7j 19 3 conventional conventional ADJ h415p843h7j 19 4 nir nir PROPN h415p843h7j 19 5 fluorophores fluorophore NOUN h415p843h7j 19 6 such such ADJ h415p843h7j 19 7 as as ADP h415p843h7j 19 8 cy5 cy5 PROPN h415p843h7j 19 9 , , PUNCT h415p843h7j 19 10 squaraine squaraine ADJ h415p843h7j 19 11 rotaxanes rotaxane NOUN h415p843h7j 19 12 are be AUX h415p843h7j 19 13 brighter bright ADJ h415p843h7j 19 14 , , PUNCT h415p843h7j 19 15 much much ADV h415p843h7j 19 16 more more ADV h415p843h7j 19 17 stable stable ADJ h415p843h7j 19 18 , , PUNCT h415p843h7j 19 19 and and CCONJ h415p843h7j 19 20 do do VERB h415p843h7j 19 21 not not PART h415p843h7j 19 22 self self NOUN h415p843h7j 19 23 - - PUNCT h415p843h7j 19 24 quench quench NOUN h415p843h7j 19 25 , , PUNCT h415p843h7j 19 26 thus thus ADV h415p843h7j 19 27 they they PRON h415p843h7j 19 28 are be AUX h415p843h7j 19 29 superior superior ADJ h415p843h7j 19 30 replacements replacement NOUN h415p843h7j 19 31 in in ADP h415p843h7j 19 32 many many ADJ h415p843h7j 19 33 bioimaging bioimaging NOUN h415p843h7j 19 34 applications application NOUN h415p843h7j 19 35 . . PUNCT