id sid tid token lemma pos gx41mg7800s 1 1 mycobacterium mycobacterium NOUN gx41mg7800s 1 2 tuberculosis tuberculosis NOUN gx41mg7800s 1 3 causes cause VERB gx41mg7800s 1 4 tuberculosis tuberculosis NOUN gx41mg7800s 1 5 ( ( PUNCT gx41mg7800s 1 6 tb tb PROPN gx41mg7800s 1 7 ) ) PUNCT gx41mg7800s 1 8 , , PUNCT gx41mg7800s 1 9 the the DET gx41mg7800s 1 10 leading lead VERB gx41mg7800s 1 11 cause cause NOUN gx41mg7800s 1 12 of of ADP gx41mg7800s 1 13 death death NOUN gx41mg7800s 1 14 globally globally ADV gx41mg7800s 1 15 from from ADP gx41mg7800s 1 16 a a DET gx41mg7800s 1 17 single single ADJ gx41mg7800s 1 18 infectious infectious ADJ gx41mg7800s 1 19 disease disease NOUN gx41mg7800s 1 20 . . PUNCT gx41mg7800s 2 1 tb tb PROPN gx41mg7800s 2 2 eradication eradication NOUN gx41mg7800s 2 3 will will AUX gx41mg7800s 2 4 require require VERB gx41mg7800s 2 5 improved improved ADJ gx41mg7800s 2 6 control control NOUN gx41mg7800s 2 7 strategies strategy NOUN gx41mg7800s 2 8 necessitating necessitate VERB gx41mg7800s 2 9 new new ADJ gx41mg7800s 2 10 insights insight NOUN gx41mg7800s 2 11 into into ADP gx41mg7800s 2 12 the the DET gx41mg7800s 2 13 basic basic ADJ gx41mg7800s 2 14 biology biology NOUN gx41mg7800s 2 15 of of ADP gx41mg7800s 2 16 mycobacteria mycobacteria PROPN gx41mg7800s 2 17 . . PUNCT gx41mg7800s 3 1 mycobacterium mycobacterium PROPN gx41mg7800s 3 2 marinum marinum PROPN gx41mg7800s 3 3 , , PUNCT gx41mg7800s 3 4 a a DET gx41mg7800s 3 5 related related ADJ gx41mg7800s 3 6 environmental environmental ADJ gx41mg7800s 3 7 pathogen pathogen NOUN gx41mg7800s 3 8 that that PRON gx41mg7800s 3 9 uses use VERB gx41mg7800s 3 10 many many ADJ gx41mg7800s 3 11 of of ADP gx41mg7800s 3 12 the the DET gx41mg7800s 3 13 same same ADJ gx41mg7800s 3 14 conserved conserved ADJ gx41mg7800s 3 15 virulence virulence NOUN gx41mg7800s 3 16 mechanisms mechanism NOUN gx41mg7800s 3 17 as as ADP gx41mg7800s 3 18 m. m. NOUN gx41mg7800s 3 19 tb tb PROPN gx41mg7800s 3 20 . . PROPN gx41mg7800s 3 21 serves serve VERB gx41mg7800s 3 22 as as ADP gx41mg7800s 3 23 a a DET gx41mg7800s 3 24 mycobacterial mycobacterial ADJ gx41mg7800s 3 25 disease disease NOUN gx41mg7800s 3 26 model model NOUN gx41mg7800s 3 27 . . PUNCT gx41mg7800s 4 1 using use VERB gx41mg7800s 4 2 m. m. NOUN gx41mg7800s 4 3 marinum marinum PROPN gx41mg7800s 4 4 we we PRON gx41mg7800s 4 5 studied study VERB gx41mg7800s 4 6 the the DET gx41mg7800s 4 7 modification modification NOUN gx41mg7800s 4 8 , , PUNCT gx41mg7800s 4 9 regulation regulation NOUN gx41mg7800s 4 10 and and CCONJ gx41mg7800s 4 11 transport transport NOUN gx41mg7800s 4 12 of of ADP gx41mg7800s 4 13 mycobacterial mycobacterial ADJ gx41mg7800s 4 14 virulence virulence NOUN gx41mg7800s 4 15 factors factor NOUN gx41mg7800s 4 16 through through ADP gx41mg7800s 4 17 biochemical biochemical ADJ gx41mg7800s 4 18 , , PUNCT gx41mg7800s 4 19 molecular molecular ADJ gx41mg7800s 4 20 and and CCONJ gx41mg7800s 4 21 genetic genetic ADJ gx41mg7800s 4 22 approaches approach NOUN gx41mg7800s 4 23 . . PUNCT gx41mg7800s 5 1 n n X gx41mg7800s 5 2 - - PUNCT gx41mg7800s 5 3 terminal terminal ADJ gx41mg7800s 5 4 acetylation acetylation NOUN gx41mg7800s 5 5 is be AUX gx41mg7800s 5 6 a a DET gx41mg7800s 5 7 protein protein NOUN gx41mg7800s 5 8 modification modification NOUN gx41mg7800s 5 9 that that PRON gx41mg7800s 5 10 remains remains AUX gx41mg7800s 5 11 poorly poorly ADV gx41mg7800s 5 12 understood understand VERB gx41mg7800s 5 13 in in ADP gx41mg7800s 5 14 bacteria bacteria NOUN gx41mg7800s 5 15 . . PUNCT gx41mg7800s 6 1 many many ADJ gx41mg7800s 6 2 proteins protein NOUN gx41mg7800s 6 3 involved involve VERB gx41mg7800s 6 4 in in ADP gx41mg7800s 6 5 mycobacterial mycobacterial ADJ gx41mg7800s 6 6 disease disease NOUN gx41mg7800s 6 7 are be AUX gx41mg7800s 6 8 nt not PART gx41mg7800s 6 9 - - PUNCT gx41mg7800s 6 10 acetylated acetylate VERB gx41mg7800s 6 11 and and CCONJ gx41mg7800s 6 12 mycobacteria mycobacteria NOUN gx41mg7800s 6 13 have have VERB gx41mg7800s 6 14 numerous numerous ADJ gx41mg7800s 6 15 potential potential ADJ gx41mg7800s 6 16 n n NOUN gx41mg7800s 6 17 - - NOUN gx41mg7800s 6 18 acetyltransferase acetyltransferase NOUN gx41mg7800s 6 19 ( ( PUNCT gx41mg7800s 6 20 nat nat NOUN gx41mg7800s 6 21 ) ) PUNCT gx41mg7800s 6 22 enzymes enzyme NOUN gx41mg7800s 6 23 . . PUNCT gx41mg7800s 7 1 the the DET gx41mg7800s 7 2 identities identity NOUN gx41mg7800s 7 3 of of ADP gx41mg7800s 7 4 which which PRON gx41mg7800s 7 5 nat nat NOUN gx41mg7800s 7 6 enzymes enzyme NOUN gx41mg7800s 7 7 nt not PART gx41mg7800s 7 8 - - PUNCT gx41mg7800s 7 9 acetylate acetylate VERB gx41mg7800s 7 10 which which DET gx41mg7800s 7 11 proteins protein NOUN gx41mg7800s 7 12 remain remain VERB gx41mg7800s 7 13 largely largely ADV gx41mg7800s 7 14 unknown unknown ADJ gx41mg7800s 7 15 . . PUNCT gx41mg7800s 8 1 we we PRON gx41mg7800s 8 2 developed develop VERB gx41mg7800s 8 3 a a DET gx41mg7800s 8 4 technique technique NOUN gx41mg7800s 8 5 to to PART gx41mg7800s 8 6 screen screen NOUN gx41mg7800s 8 7 nat nat NOUN gx41mg7800s 8 8 enzymes enzyme NOUN gx41mg7800s 8 9 for for ADP gx41mg7800s 8 10 nt not PART gx41mg7800s 8 11 - - PUNCT gx41mg7800s 8 12 acetylation acetylation NOUN gx41mg7800s 8 13 activity activity NOUN gx41mg7800s 8 14 . . PUNCT gx41mg7800s 9 1 we we PRON gx41mg7800s 9 2 identified identify VERB gx41mg7800s 9 3 nat nat NOUN gx41mg7800s 9 4 enzymes enzyme NOUN gx41mg7800s 9 5 that that PRON gx41mg7800s 9 6 nt not PART gx41mg7800s 9 7 - - PUNCT gx41mg7800s 9 8 acetylated acetylate VERB gx41mg7800s 9 9 the the DET gx41mg7800s 9 10 virulence virulence NOUN gx41mg7800s 9 11 factor factor NOUN gx41mg7800s 9 12 esxa esxa NOUN gx41mg7800s 9 13 and and CCONJ gx41mg7800s 9 14 demonstrated demonstrate VERB gx41mg7800s 9 15 that that SCONJ gx41mg7800s 9 16 the the DET gx41mg7800s 9 17 loss loss NOUN gx41mg7800s 9 18 of of ADP gx41mg7800s 9 19 one one NUM gx41mg7800s 9 20 of of ADP gx41mg7800s 9 21 these these DET gx41mg7800s 9 22 enzymes enzyme NOUN gx41mg7800s 9 23 alters alter VERB gx41mg7800s 9 24 virulence virulence NOUN gx41mg7800s 9 25 . . PUNCT gx41mg7800s 10 1 in in ADP gx41mg7800s 10 2 a a DET gx41mg7800s 10 3 complementary complementary ADJ gx41mg7800s 10 4 approach approach NOUN gx41mg7800s 10 5 , , PUNCT gx41mg7800s 10 6 we we PRON gx41mg7800s 10 7 generated generate VERB gx41mg7800s 10 8 a a DET gx41mg7800s 10 9 collection collection NOUN gx41mg7800s 10 10 of of ADP gx41mg7800s 10 11 m. m. PROPN gx41mg7800s 10 12 marinum marinum PROPN gx41mg7800s 10 13 strains strain VERB gx41mg7800s 10 14 with with ADP gx41mg7800s 10 15 deletions deletion NOUN gx41mg7800s 10 16 of of ADP gx41mg7800s 10 17 conserved conserved PROPN gx41mg7800s 10 18 nat nat PROPN gx41mg7800s 10 19 genes gene NOUN gx41mg7800s 10 20 . . PUNCT gx41mg7800s 11 1 through through ADP gx41mg7800s 11 2 this this DET gx41mg7800s 11 3 approach approach NOUN gx41mg7800s 11 4 , , PUNCT gx41mg7800s 11 5 we we PRON gx41mg7800s 11 6 identified identify VERB gx41mg7800s 11 7 a a DET gx41mg7800s 11 8 previously previously ADV gx41mg7800s 11 9 unknown unknown ADJ gx41mg7800s 11 10 genetic genetic ADJ gx41mg7800s 11 11 interaction interaction NOUN gx41mg7800s 11 12 between between ADP gx41mg7800s 11 13 two two NUM gx41mg7800s 11 14 nat nat NOUN gx41mg7800s 11 15 genes gene NOUN gx41mg7800s 11 16 and and CCONJ gx41mg7800s 11 17 built build VERB gx41mg7800s 11 18 tools tool NOUN gx41mg7800s 11 19 for for ADP gx41mg7800s 11 20 its its PRON gx41mg7800s 11 21 further further ADJ gx41mg7800s 11 22 characterization characterization NOUN gx41mg7800s 11 23 . . PUNCT gx41mg7800s 12 1 virulence virulence NOUN gx41mg7800s 12 2 in in ADP gx41mg7800s 12 3 m. m. NOUN gx41mg7800s 12 4 marinum marinum PROPN gx41mg7800s 12 5 and and CCONJ gx41mg7800s 12 6 m. m. NOUN gx41mg7800s 12 7 tb tb PROPN gx41mg7800s 12 8 . . PROPN gx41mg7800s 12 9 requires require VERB gx41mg7800s 12 10 the the DET gx41mg7800s 12 11 secretion secretion NOUN gx41mg7800s 12 12 of of ADP gx41mg7800s 12 13 virulence virulence NOUN gx41mg7800s 12 14 factors factor NOUN gx41mg7800s 12 15 by by ADP gx41mg7800s 12 16 the the DET gx41mg7800s 12 17 esx-1 esx-1 X gx41mg7800s 12 18 ( ( PUNCT gx41mg7800s 12 19 esat-6 esat-6 NOUN gx41mg7800s 12 20 - - PUNCT gx41mg7800s 12 21 system-1 system-1 NUM gx41mg7800s 12 22 ) ) PUNCT gx41mg7800s 12 23 protein protein NOUN gx41mg7800s 12 24 export export NOUN gx41mg7800s 12 25 system system NOUN gx41mg7800s 12 26 . . PUNCT gx41mg7800s 13 1 expression expression NOUN gx41mg7800s 13 2 of of ADP gx41mg7800s 13 3 the the DET gx41mg7800s 13 4 secreted secrete VERB gx41mg7800s 13 5 virulence virulence NOUN gx41mg7800s 13 6 factors factor NOUN gx41mg7800s 13 7 is be AUX gx41mg7800s 13 8 a a DET gx41mg7800s 13 9 regulated regulate VERB gx41mg7800s 13 10 process process NOUN gx41mg7800s 13 11 dependent dependent ADJ gx41mg7800s 13 12 upon upon SCONJ gx41mg7800s 13 13 an an DET gx41mg7800s 13 14 intact intact ADJ gx41mg7800s 13 15 esx-1 esx-1 X gx41mg7800s 13 16 system system NOUN gx41mg7800s 13 17 . . PUNCT gx41mg7800s 14 1 we we PRON gx41mg7800s 14 2 investigated investigate VERB gx41mg7800s 14 3 the the DET gx41mg7800s 14 4 mechanisms mechanism NOUN gx41mg7800s 14 5 of of ADP gx41mg7800s 14 6 this this DET gx41mg7800s 14 7 regulation regulation NOUN gx41mg7800s 14 8 and and CCONJ gx41mg7800s 14 9 identified identify VERB gx41mg7800s 14 10 the the DET gx41mg7800s 14 11 transcriptional transcriptional ADJ gx41mg7800s 14 12 repressor repressor NOUN gx41mg7800s 14 13 espm espm NOUN gx41mg7800s 14 14 which which PRON gx41mg7800s 14 15 is be AUX gx41mg7800s 14 16 required require VERB gx41mg7800s 14 17 for for ADP gx41mg7800s 14 18 repressing repress VERB gx41mg7800s 14 19 virulence virulence NOUN gx41mg7800s 14 20 factor factor NOUN gx41mg7800s 14 21 expression expression NOUN gx41mg7800s 14 22 in in ADP gx41mg7800s 14 23 the the DET gx41mg7800s 14 24 absence absence NOUN gx41mg7800s 14 25 of of ADP gx41mg7800s 14 26 a a DET gx41mg7800s 14 27 functional functional ADJ gx41mg7800s 14 28 esx-1 esx-1 X gx41mg7800s 14 29 system system NOUN gx41mg7800s 14 30 . . PUNCT gx41mg7800s 15 1 it it PRON gx41mg7800s 15 2 was be AUX gx41mg7800s 15 3 thought think VERB gx41mg7800s 15 4 that that SCONJ gx41mg7800s 15 5 virulence virulence NOUN gx41mg7800s 15 6 factors factor NOUN gx41mg7800s 15 7 ( ( PUNCT gx41mg7800s 15 8 substrates substrate NOUN gx41mg7800s 15 9 ) ) PUNCT gx41mg7800s 15 10 secreted secrete VERB gx41mg7800s 15 11 by by ADP gx41mg7800s 15 12 the the DET gx41mg7800s 15 13 esx-1 esx-1 NOUN gx41mg7800s 15 14 were be AUX gx41mg7800s 15 15 interdependent interdependent ADJ gx41mg7800s 15 16 for for ADP gx41mg7800s 15 17 secretion secretion NOUN gx41mg7800s 15 18 with with ADP gx41mg7800s 15 19 loss loss NOUN gx41mg7800s 15 20 of of ADP gx41mg7800s 15 21 one one NUM gx41mg7800s 15 22 substrate substrate NOUN gx41mg7800s 15 23 abolishing abolish VERB gx41mg7800s 15 24 the the DET gx41mg7800s 15 25 secretion secretion NOUN gx41mg7800s 15 26 of of ADP gx41mg7800s 15 27 others other NOUN gx41mg7800s 15 28 . . PUNCT gx41mg7800s 16 1 we we PRON gx41mg7800s 16 2 built build VERB gx41mg7800s 16 3 a a DET gx41mg7800s 16 4 series series NOUN gx41mg7800s 16 5 of of ADP gx41mg7800s 16 6 substrate substrate NOUN gx41mg7800s 16 7 deletion deletion NOUN gx41mg7800s 16 8 strains strain NOUN gx41mg7800s 16 9 and and CCONJ gx41mg7800s 16 10 characterized characterize VERB gx41mg7800s 16 11 their their PRON gx41mg7800s 16 12 esx-1 esx-1 X gx41mg7800s 16 13 secretion secretion NOUN gx41mg7800s 16 14 . . PUNCT gx41mg7800s 17 1 we we PRON gx41mg7800s 17 2 determined determine VERB gx41mg7800s 17 3 that that SCONJ gx41mg7800s 17 4 substrates substrate NOUN gx41mg7800s 17 5 are be AUX gx41mg7800s 17 6 not not PART gx41mg7800s 17 7 strictly strictly ADV gx41mg7800s 17 8 interdependent interdependent ADJ gx41mg7800s 17 9 for for ADP gx41mg7800s 17 10 secretion secretion NOUN gx41mg7800s 17 11 , , PUNCT gx41mg7800s 17 12 consistent consistent ADJ gx41mg7800s 17 13 with with ADP gx41mg7800s 17 14 our our PRON gx41mg7800s 17 15 previous previous ADJ gx41mg7800s 17 16 work work NOUN gx41mg7800s 17 17 . . PUNCT gx41mg7800s 18 1 together together ADV gx41mg7800s 18 2 our our PRON gx41mg7800s 18 3 work work NOUN gx41mg7800s 18 4 illustrates illustrate VERB gx41mg7800s 18 5 multiple multiple ADJ gx41mg7800s 18 6 dynamic dynamic ADJ gx41mg7800s 18 7 processes process NOUN gx41mg7800s 18 8 involved involve VERB gx41mg7800s 18 9 in in ADP gx41mg7800s 18 10 mycobacterial mycobacterial ADJ gx41mg7800s 18 11 virulence virulence NOUN gx41mg7800s 18 12 . . PUNCT gx41mg7800s 19 1 by by ADP gx41mg7800s 19 2 utilizing utilize VERB gx41mg7800s 19 3 m. m. NOUN gx41mg7800s 19 4 marinum marinum PROPN gx41mg7800s 19 5 as as ADP gx41mg7800s 19 6 a a DET gx41mg7800s 19 7 model model NOUN gx41mg7800s 19 8 we we PRON gx41mg7800s 19 9 have have AUX gx41mg7800s 19 10 gained gain VERB gx41mg7800s 19 11 new new ADJ gx41mg7800s 19 12 insights insight NOUN gx41mg7800s 19 13 into into ADP gx41mg7800s 19 14 protein protein NOUN gx41mg7800s 19 15 homeostasis homeostasis NOUN gx41mg7800s 19 16 , , PUNCT gx41mg7800s 19 17 virulence virulence NOUN gx41mg7800s 19 18 regulation regulation NOUN gx41mg7800s 19 19 and and CCONJ gx41mg7800s 19 20 virulence virulence NOUN gx41mg7800s 19 21 factor factor NOUN gx41mg7800s 19 22 secretion secretion NOUN gx41mg7800s 19 23 , , PUNCT gx41mg7800s 19 24 which which PRON gx41mg7800s 19 25 will will AUX gx41mg7800s 19 26 inform inform VERB gx41mg7800s 19 27 future future ADJ gx41mg7800s 19 28 studies study NOUN gx41mg7800s 19 29 in in ADP gx41mg7800s 19 30 m. m. NOUN gx41mg7800s 19 31 tuberculosis tuberculosis NOUN gx41mg7800s 19 32 . . PUNCT