id	sid	tid	token	lemma	pos
gf06g161p9v	1	1	protein	protein	NOUN
gf06g161p9v	1	2	-	-	PUNCT
gf06g161p9v	1	3	protein	protein	NOUN
gf06g161p9v	1	4	interactions	interaction	NOUN
gf06g161p9v	1	5	play	play	VERB
gf06g161p9v	1	6	important	important	ADJ
gf06g161p9v	1	7	roles	role	NOUN
gf06g161p9v	1	8	at	at	ADP
gf06g161p9v	1	9	all	all	DET
gf06g161p9v	1	10	levels	level	NOUN
gf06g161p9v	1	11	of	of	ADP
gf06g161p9v	1	12	cellular	cellular	ADJ
gf06g161p9v	1	13	organization	organization	NOUN
gf06g161p9v	1	14	and	and	CCONJ
gf06g161p9v	1	15	thus	thus	ADV
gf06g161p9v	1	16	are	be	AUX
gf06g161p9v	1	17	therapeutically	therapeutically	ADV
gf06g161p9v	1	18	relevant	relevant	ADJ
gf06g161p9v	1	19	targets	target	NOUN
gf06g161p9v	1	20	for	for	ADP
gf06g161p9v	1	21	the	the	DET
gf06g161p9v	1	22	treatment	treatment	NOUN
gf06g161p9v	1	23	of	of	ADP
gf06g161p9v	1	24	a	a	DET
gf06g161p9v	1	25	wide	wide	ADJ
gf06g161p9v	1	26	array	array	NOUN
gf06g161p9v	1	27	of	of	ADP
gf06g161p9v	1	28	diseases	disease	NOUN
gf06g161p9v	1	29	.	.	PUNCT
gf06g161p9v	2	1	modulators	modulator	NOUN
gf06g161p9v	2	2	of	of	ADP
gf06g161p9v	2	3	protein	protein	NOUN
gf06g161p9v	2	4	-	-	PUNCT
gf06g161p9v	2	5	protein	protein	NOUN
gf06g161p9v	2	6	interactions	interaction	NOUN
gf06g161p9v	2	7	are	be	AUX
gf06g161p9v	2	8	therefore	therefore	ADV
gf06g161p9v	2	9	highly	highly	ADV
gf06g161p9v	2	10	valuable	valuable	ADJ
gf06g161p9v	2	11	molecules	molecule	NOUN
gf06g161p9v	2	12	sought	seek	VERB
gf06g161p9v	2	13	after	after	ADP
gf06g161p9v	2	14	in	in	ADP
gf06g161p9v	2	15	many	many	ADJ
gf06g161p9v	2	16	drug	drug	NOUN
gf06g161p9v	2	17	discovery	discovery	NOUN
gf06g161p9v	2	18	endeavors	endeavor	NOUN
gf06g161p9v	2	19	.	.	PUNCT
gf06g161p9v	3	1	peptides	peptide	NOUN
gf06g161p9v	3	2	that	that	PRON
gf06g161p9v	3	3	emulate	emulate	VERB
gf06g161p9v	3	4	protein	protein	NOUN
gf06g161p9v	3	5	domains	domain	NOUN
gf06g161p9v	3	6	at	at	ADP
gf06g161p9v	3	7	protein	protein	NOUN
gf06g161p9v	3	8	-	-	PUNCT
gf06g161p9v	3	9	protein	protein	NOUN
gf06g161p9v	3	10	interfaces	interface	NOUN
gf06g161p9v	3	11	represent	represent	VERB
gf06g161p9v	3	12	a	a	DET
gf06g161p9v	3	13	promising	promising	ADJ
gf06g161p9v	3	14	strategy	strategy	NOUN
gf06g161p9v	3	15	for	for	ADP
gf06g161p9v	3	16	drug	drug	NOUN
gf06g161p9v	3	17	development	development	NOUN
gf06g161p9v	3	18	.	.	PUNCT
gf06g161p9v	4	1	as	as	SCONJ
gf06g161p9v	4	2	the	the	DET
gf06g161p9v	4	3	functions	function	NOUN
gf06g161p9v	4	4	and	and	CCONJ
gf06g161p9v	4	5	binding	bind	VERB
gf06g161p9v	4	6	affinities	affinity	NOUN
gf06g161p9v	4	7	of	of	ADP
gf06g161p9v	4	8	proteins	protein	NOUN
gf06g161p9v	4	9	are	be	AUX
gf06g161p9v	4	10	directly	directly	ADV
gf06g161p9v	4	11	related	relate	VERB
gf06g161p9v	4	12	to	to	ADP
gf06g161p9v	4	13	their	their	PRON
gf06g161p9v	4	14	three	three	NUM
gf06g161p9v	4	15	-	-	PUNCT
gf06g161p9v	4	16	dimensional	dimensional	ADJ
gf06g161p9v	4	17	structure	structure	NOUN
gf06g161p9v	4	18	,	,	PUNCT
gf06g161p9v	4	19	peptidomimetic	peptidomimetic	ADJ
gf06g161p9v	4	20	approaches	approach	NOUN
gf06g161p9v	4	21	seek	seek	VERB
gf06g161p9v	4	22	to	to	PART
gf06g161p9v	4	23	recreate	recreate	VERB
gf06g161p9v	4	24	folded	fold	VERB
gf06g161p9v	4	25	elements	element	NOUN
gf06g161p9v	4	26	of	of	ADP
gf06g161p9v	4	27	proteins	protein	NOUN
gf06g161p9v	4	28	with	with	ADP
gf06g161p9v	4	29	high	high	ADJ
gf06g161p9v	4	30	-	-	PUNCT
gf06g161p9v	4	31	fidelity	fidelity	NOUN
gf06g161p9v	4	32	,	,	PUNCT
gf06g161p9v	4	33	independent	independent	ADJ
gf06g161p9v	4	34	of	of	ADP
gf06g161p9v	4	35	the	the	DET
gf06g161p9v	4	36	larger	large	ADJ
gf06g161p9v	4	37	folded	folded	ADJ
gf06g161p9v	4	38	context	context	NOUN
gf06g161p9v	4	39	from	from	ADP
gf06g161p9v	4	40	which	which	PRON
gf06g161p9v	4	41	they	they	PRON
gf06g161p9v	4	42	are	be	AUX
gf06g161p9v	4	43	derived	derive	VERB
gf06g161p9v	4	44	.	.	PUNCT
gf06g161p9v	5	1	this	this	PRON
gf06g161p9v	5	2	can	can	AUX
gf06g161p9v	5	3	be	be	AUX
gf06g161p9v	5	4	achieved	achieve	VERB
gf06g161p9v	5	5	by	by	ADP
gf06g161p9v	5	6	using	use	VERB
gf06g161p9v	5	7	macrocyclization	macrocyclization	NOUN
gf06g161p9v	5	8	to	to	PART
gf06g161p9v	5	9	constrain	constrain	VERB
gf06g161p9v	5	10	peptides	peptide	NOUN
gf06g161p9v	5	11	into	into	ADP
gf06g161p9v	5	12	their	their	PRON
gf06g161p9v	5	13	unique	unique	ADJ
gf06g161p9v	5	14	and	and	CCONJ
gf06g161p9v	5	15	bioactive	bioactive	ADJ
gf06g161p9v	5	16	conformations	conformation	NOUN
gf06g161p9v	5	17	.	.	PUNCT
gf06g161p9v	6	1	macrocyclic	macrocyclic	NOUN
gf06g161p9v	6	2	-	-	PUNCT
gf06g161p9v	6	3	based	base	VERB
gf06g161p9v	6	4	designs	design	NOUN
gf06g161p9v	6	5	of	of	ADP
gf06g161p9v	6	6	biologically	biologically	ADV
gf06g161p9v	6	7	relevant	relevant	ADJ
gf06g161p9v	6	8	peptides	peptide	NOUN
gf06g161p9v	6	9	may	may	AUX
gf06g161p9v	6	10	be	be	AUX
gf06g161p9v	6	11	informed	inform	VERB
gf06g161p9v	6	12	by	by	ADP
gf06g161p9v	6	13	the	the	DET
gf06g161p9v	6	14	patterns	pattern	NOUN
gf06g161p9v	6	15	of	of	ADP
gf06g161p9v	6	16	hydrogen	hydrogen	NOUN
gf06g161p9v	6	17	bonding	bonding	NOUN
gf06g161p9v	6	18	observed	observe	VERB
gf06g161p9v	6	19	in	in	ADP
gf06g161p9v	6	20	x	x	NOUN
gf06g161p9v	6	21	-	-	NOUN
gf06g161p9v	6	22	ray	ray	NOUN
gf06g161p9v	6	23	crystal	crystal	NOUN
gf06g161p9v	6	24	structures	structure	NOUN
gf06g161p9v	6	25	.	.	PUNCT
gf06g161p9v	7	1	covalent	covalent	NOUN
gf06g161p9v	7	2	surrogates	surrogate	NOUN
gf06g161p9v	7	3	of	of	ADP
gf06g161p9v	7	4	hydrogen	hydrogen	NOUN
gf06g161p9v	7	5	bonds	bond	NOUN
gf06g161p9v	7	6	reduce	reduce	VERB
gf06g161p9v	7	7	entropy	entropy	NOUN
gf06g161p9v	7	8	by	by	ADP
gf06g161p9v	7	9	destabilizing	destabilizing	ADJ
gf06g161p9v	7	10	unfolded	unfolded	ADJ
gf06g161p9v	7	11	states	state	NOUN
gf06g161p9v	7	12	and	and	CCONJ
gf06g161p9v	7	13	support	support	VERB
gf06g161p9v	7	14	the	the	DET
gf06g161p9v	7	15	natural	natural	ADJ
gf06g161p9v	7	16	tendency	tendency	NOUN
gf06g161p9v	7	17	of	of	ADP
gf06g161p9v	7	18	the	the	DET
gf06g161p9v	7	19	encoded	encode	VERB
gf06g161p9v	7	20	polymer	polymer	NOUN
gf06g161p9v	7	21	chain	chain	NOUN
gf06g161p9v	7	22	to	to	PART
gf06g161p9v	7	23	fold	fold	VERB
gf06g161p9v	7	24	into	into	ADP
gf06g161p9v	7	25	complex	complex	ADJ
gf06g161p9v	7	26	structures.as	structures.as	X
gf06g161p9v	7	27	unmodified	unmodified	ADJ
gf06g161p9v	7	28	peptides	peptide	NOUN
gf06g161p9v	7	29	tend	tend	VERB
gf06g161p9v	7	30	to	to	PART
gf06g161p9v	7	31	be	be	AUX
gf06g161p9v	7	32	disordered	disorder	VERB
gf06g161p9v	7	33	in	in	ADP
gf06g161p9v	7	34	solution	solution	NOUN
gf06g161p9v	7	35	,	,	PUNCT
gf06g161p9v	7	36	macrocyclization	macrocyclization	NOUN
gf06g161p9v	7	37	is	be	AUX
gf06g161p9v	7	38	routinely	routinely	ADV
gf06g161p9v	7	39	employed	employ	VERB
gf06g161p9v	7	40	to	to	PART
gf06g161p9v	7	41	constrain	constrain	VERB
gf06g161p9v	7	42	native	native	ADJ
gf06g161p9v	7	43	peptide	peptide	NOUN
gf06g161p9v	7	44	epitopes	epitope	NOUN
gf06g161p9v	7	45	in	in	ADP
gf06g161p9v	7	46	their	their	PRON
gf06g161p9v	7	47	bioactive	bioactive	ADJ
gf06g161p9v	7	48	conformation	conformation	NOUN
gf06g161p9v	7	49	.	.	PUNCT
gf06g161p9v	8	1	macrocyclization	macrocyclization	NOUN
gf06g161p9v	8	2	involving	involve	VERB
gf06g161p9v	8	3	internal	internal	ADJ
gf06g161p9v	8	4	backbone	backbone	NOUN
gf06g161p9v	8	5	amides	amide	NOUN
gf06g161p9v	8	6	is	be	AUX
gf06g161p9v	8	7	an	an	DET
gf06g161p9v	8	8	underexplored	underexplored	ADJ
gf06g161p9v	8	9	mode	mode	NOUN
gf06g161p9v	8	10	of	of	ADP
gf06g161p9v	8	11	connectivity	connectivity	NOUN
gf06g161p9v	8	12	and	and	CCONJ
gf06g161p9v	8	13	the	the	DET
gf06g161p9v	8	14	methodology	methodology	NOUN
gf06g161p9v	8	15	to	to	PART
gf06g161p9v	8	16	functionalize	functionalize	VERB
gf06g161p9v	8	17	these	these	DET
gf06g161p9v	8	18	amides	amide	NOUN
gf06g161p9v	8	19	with	with	ADP
gf06g161p9v	8	20	reactive	reactive	ADJ
gf06g161p9v	8	21	handles	handle	NOUN
gf06g161p9v	8	22	for	for	ADP
gf06g161p9v	8	23	cross	cross	ADJ
gf06g161p9v	8	24	-	-	ADJ
gf06g161p9v	8	25	linking	linking	NOUN
gf06g161p9v	8	26	has	have	AUX
gf06g161p9v	8	27	mostly	mostly	ADV
gf06g161p9v	8	28	been	be	AUX
gf06g161p9v	8	29	limited	limit	VERB
gf06g161p9v	8	30	to	to	ADP
gf06g161p9v	8	31	n	n	NOUN
gf06g161p9v	8	32	-	-	NOUN
gf06g161p9v	8	33	alkylation	alkylation	NOUN
gf06g161p9v	8	34	.	.	PUNCT
gf06g161p9v	9	1	herein	herein	ADV
gf06g161p9v	9	2	,	,	PUNCT
gf06g161p9v	9	3	we	we	PRON
gf06g161p9v	9	4	demonstrate	demonstrate	VERB
gf06g161p9v	9	5	a	a	DET
gf06g161p9v	9	6	late	late	ADJ
gf06g161p9v	9	7	-	-	PUNCT
gf06g161p9v	9	8	stage	stage	NOUN
gf06g161p9v	9	9	bis	bis	ADJ
gf06g161p9v	9	10	-	-	PUNCT
gf06g161p9v	9	11	alkylation	alkylation	NOUN
gf06g161p9v	9	12	reaction	reaction	NOUN
gf06g161p9v	9	13	of	of	ADP
gf06g161p9v	9	14	n	n	ADJ
gf06g161p9v	9	15	-	-	PUNCT
gf06g161p9v	9	16	amino	amino	NOUN
gf06g161p9v	9	17	peptides	peptide	NOUN
gf06g161p9v	9	18	with	with	ADP
gf06g161p9v	9	19	haloaldehydes	haloaldehyde	NOUN
gf06g161p9v	9	20	to	to	PART
gf06g161p9v	9	21	afford	afford	VERB
gf06g161p9v	9	22	ethylene	ethylene	NOUN
gf06g161p9v	9	23	bridged	bridge	VERB
gf06g161p9v	9	24	n	n	ADJ
gf06g161p9v	9	25	-	-	PUNCT
gf06g161p9v	9	26	amino	amino	NOUN
gf06g161p9v	9	27	peptide	peptide	NOUN
gf06g161p9v	9	28	macrocycles	macrocycle	NOUN
gf06g161p9v	9	29	(	(	PUNCT
gf06g161p9v	9	30	naprocycles	naprocycle	NOUN
gf06g161p9v	9	31	)	)	PUNCT
gf06g161p9v	9	32	.	.	PUNCT
gf06g161p9v	10	1	our	our	PRON
gf06g161p9v	10	2	approach	approach	NOUN
gf06g161p9v	10	3	is	be	AUX
gf06g161p9v	10	4	based	base	VERB
gf06g161p9v	10	5	on	on	ADP
gf06g161p9v	10	6	the	the	DET
gf06g161p9v	10	7	utilization	utilization	NOUN
gf06g161p9v	10	8	of	of	ADP
gf06g161p9v	10	9	backbone	backbone	NOUN
gf06g161p9v	10	10	n	n	ADJ
gf06g161p9v	10	11	-	-	PUNCT
gf06g161p9v	10	12	amino	amino	ADJ
gf06g161p9v	10	13	groups	group	NOUN
gf06g161p9v	10	14	as	as	ADP
gf06g161p9v	10	15	reactive	reactive	ADJ
gf06g161p9v	10	16	handles	handle	NOUN
gf06g161p9v	10	17	in	in	ADP
gf06g161p9v	10	18	bioorthogonal	bioorthogonal	ADJ
gf06g161p9v	10	19	reactions	reaction	NOUN
gf06g161p9v	10	20	to	to	PART
gf06g161p9v	10	21	synthesize	synthesize	VERB
gf06g161p9v	10	22	macrocyclic	macrocyclic	NOUN
gf06g161p9v	10	23	peptides	peptide	NOUN
gf06g161p9v	10	24	.	.	PUNCT
gf06g161p9v	11	1	using	use	VERB
gf06g161p9v	11	2	this	this	DET
gf06g161p9v	11	3	approach	approach	NOUN
gf06g161p9v	11	4	,	,	PUNCT
gf06g161p9v	11	5	we	we	PRON
gf06g161p9v	11	6	prepare	prepare	VERB
gf06g161p9v	11	7	a	a	DET
gf06g161p9v	11	8	series	series	NOUN
gf06g161p9v	11	9	of	of	ADP
gf06g161p9v	11	10	macrocycles	macrocycle	NOUN
gf06g161p9v	11	11	with	with	ADP
gf06g161p9v	11	12	varying	vary	VERB
gf06g161p9v	11	13	ring	ring	NOUN
gf06g161p9v	11	14	size	size	NOUN
gf06g161p9v	11	15	from	from	ADP
gf06g161p9v	11	16	crude	crude	ADJ
gf06g161p9v	11	17	,	,	PUNCT
gf06g161p9v	11	18	unprotected	unprotected	ADJ
gf06g161p9v	11	19	linear	linear	ADJ
gf06g161p9v	11	20	substrates	substrate	NOUN
gf06g161p9v	11	21	under	under	ADP
gf06g161p9v	11	22	aqueous	aqueous	ADJ
gf06g161p9v	11	23	conditions	condition	NOUN
gf06g161p9v	11	24	.	.	PUNCT
gf06g161p9v	12	1	we	we	PRON
gf06g161p9v	12	2	further	far	ADV
gf06g161p9v	12	3	incorporate	incorporate	VERB
gf06g161p9v	12	4	our	our	PRON
gf06g161p9v	12	5	covalent	covalent	NOUN
gf06g161p9v	12	6	constraint	constraint	NOUN
gf06g161p9v	12	7	into	into	ADP
gf06g161p9v	12	8	a	a	DET
gf06g161p9v	12	9	model	model	NOUN
gf06g161p9v	12	10	loop	loop	NOUN
gf06g161p9v	12	11	-	-	PUNCT
gf06g161p9v	12	12	helix	helix	NOUN
gf06g161p9v	12	13	motif	motif	NOUN
gf06g161p9v	12	14	derived	derive	VERB
gf06g161p9v	12	15	from	from	ADP
gf06g161p9v	12	16	the	the	DET
gf06g161p9v	12	17	viral	viral	ADJ
gf06g161p9v	12	18	matrix	matrix	NOUN
gf06g161p9v	12	19	protein	protein	NOUN
gf06g161p9v	12	20	vp40	vp40	PROPN
gf06g161p9v	12	21	.	.	PUNCT
gf06g161p9v	13	1	we	we	PRON
gf06g161p9v	13	2	demonstrate	demonstrate	VERB
gf06g161p9v	13	3	that	that	SCONJ
gf06g161p9v	13	4	naprocycle	naprocycle	NOUN
gf06g161p9v	13	5	constraint	constraint	NOUN
gf06g161p9v	13	6	of	of	ADP
gf06g161p9v	13	7	specific	specific	ADJ
gf06g161p9v	13	8	residues	residue	NOUN
gf06g161p9v	13	9	involved	involve	VERB
gf06g161p9v	13	10	in	in	ADP
gf06g161p9v	13	11	a	a	DET
gf06g161p9v	13	12	sidechain	sidechain	NOUN
gf06g161p9v	13	13	-	-	PUNCT
gf06g161p9v	13	14	to	to	ADP
gf06g161p9v	13	15	-	-	PUNCT
gf06g161p9v	13	16	backbone	backbone	NOUN
gf06g161p9v	13	17	hydrogen	hydrogen	NOUN
gf06g161p9v	13	18	-	-	PUNCT
gf06g161p9v	13	19	bond	bond	NOUN
gf06g161p9v	13	20	observed	observe	VERB
gf06g161p9v	13	21	in	in	ADP
gf06g161p9v	13	22	the	the	DET
gf06g161p9v	13	23	x	x	NOUN
gf06g161p9v	13	24	-	-	NOUN
gf06g161p9v	13	25	ray	ray	NOUN
gf06g161p9v	13	26	crystal	crystal	NOUN
gf06g161p9v	13	27	structure	structure	NOUN
gf06g161p9v	13	28	of	of	ADP
gf06g161p9v	13	29	dimeric	dimeric	ADJ
gf06g161p9v	13	30	vp40	vp40	PROPN
gf06g161p9v	13	31	significantly	significantly	ADV
gf06g161p9v	13	32	enhances	enhance	VERB
gf06g161p9v	13	33	helicity.to	helicity.to	X
gf06g161p9v	13	34	complement	complement	VERB
gf06g161p9v	13	35	our	our	PRON
gf06g161p9v	13	36	naprocycle	naprocycle	NOUN
gf06g161p9v	13	37	constraint	constraint	NOUN
gf06g161p9v	13	38	methodology	methodology	NOUN
gf06g161p9v	13	39	,	,	PUNCT
gf06g161p9v	13	40	we	we	PRON
gf06g161p9v	13	41	present	present	VERB
gf06g161p9v	13	42	an	an	DET
gf06g161p9v	13	43	informatics	informatic	NOUN
gf06g161p9v	13	44	analysis	analysis	NOUN
gf06g161p9v	13	45	of	of	ADP
gf06g161p9v	13	46	sidechain	sidechain	NOUN
gf06g161p9v	13	47	-	-	PUNCT
gf06g161p9v	13	48	to	to	ADP
gf06g161p9v	13	49	-	-	PUNCT
gf06g161p9v	13	50	backbone	backbone	NOUN
gf06g161p9v	13	51	hydrogen	hydrogen	NOUN
gf06g161p9v	13	52	bonds	bond	NOUN
gf06g161p9v	13	53	observed	observe	VERB
gf06g161p9v	13	54	in	in	ADP
gf06g161p9v	13	55	x	x	NOUN
gf06g161p9v	13	56	-	-	NOUN
gf06g161p9v	13	57	ray	ray	NOUN
gf06g161p9v	13	58	crystal	crystal	NOUN
gf06g161p9v	13	59	structures	structure	NOUN
gf06g161p9v	13	60	.	.	PUNCT
gf06g161p9v	14	1	we	we	PRON
gf06g161p9v	14	2	detail	detail	VERB
gf06g161p9v	14	3	the	the	DET
gf06g161p9v	14	4	compilation	compilation	NOUN
gf06g161p9v	14	5	of	of	ADP
gf06g161p9v	14	6	databases	database	NOUN
gf06g161p9v	14	7	of	of	ADP
gf06g161p9v	14	8	proteins	protein	NOUN
gf06g161p9v	14	9	containing	contain	VERB
gf06g161p9v	14	10	sidechain	sidechain	NOUN
gf06g161p9v	14	11	-	-	PUNCT
gf06g161p9v	14	12	to	to	ADP
gf06g161p9v	14	13	-	-	PUNCT
gf06g161p9v	14	14	backbone	backbone	NOUN
gf06g161p9v	14	15	hydrogen	hydrogen	NOUN
gf06g161p9v	14	16	bonds	bond	NOUN
gf06g161p9v	14	17	that	that	PRON
gf06g161p9v	14	18	may	may	AUX
gf06g161p9v	14	19	serve	serve	VERB
gf06g161p9v	14	20	as	as	ADP
gf06g161p9v	14	21	test	test	NOUN
gf06g161p9v	14	22	cases	case	NOUN
gf06g161p9v	14	23	for	for	ADP
gf06g161p9v	14	24	our	our	PRON
gf06g161p9v	14	25	covalent	covalent	ADJ
gf06g161p9v	14	26	surrogate	surrogate	ADJ
gf06g161p9v	14	27	approach	approach	NOUN
gf06g161p9v	14	28	.	.	PUNCT
gf06g161p9v	15	1	our	our	PRON
gf06g161p9v	15	2	work	work	NOUN
gf06g161p9v	15	3	offers	offer	VERB
gf06g161p9v	15	4	insight	insight	NOUN
gf06g161p9v	15	5	into	into	ADP
gf06g161p9v	15	6	the	the	DET
gf06g161p9v	15	7	nature	nature	NOUN
gf06g161p9v	15	8	and	and	CCONJ
gf06g161p9v	15	9	extent	extent	NOUN
gf06g161p9v	15	10	of	of	ADP
gf06g161p9v	15	11	interresidue	interresidue	ADJ
gf06g161p9v	15	12	sidechain	sidechain	NOUN
gf06g161p9v	15	13	-	-	PUNCT
gf06g161p9v	15	14	to	to	ADP
gf06g161p9v	15	15	-	-	PUNCT
gf06g161p9v	15	16	backbone	backbone	NOUN
gf06g161p9v	15	17	hydrogen	hydrogen	NOUN
gf06g161p9v	15	18	bonding	bonding	NOUN
gf06g161p9v	15	19	in	in	ADP
gf06g161p9v	15	20	proteins	protein	NOUN
gf06g161p9v	15	21	and	and	CCONJ
gf06g161p9v	15	22	suggests	suggest	VERB
gf06g161p9v	15	23	that	that	SCONJ
gf06g161p9v	15	24	several	several	ADJ
gf06g161p9v	15	25	of	of	ADP
gf06g161p9v	15	26	these	these	DET
gf06g161p9v	15	27	interactions	interaction	NOUN
gf06g161p9v	15	28	may	may	AUX
gf06g161p9v	15	29	play	play	VERB
gf06g161p9v	15	30	an	an	DET
gf06g161p9v	15	31	important	important	ADJ
gf06g161p9v	15	32	role	role	NOUN
gf06g161p9v	15	33	in	in	ADP
gf06g161p9v	15	34	protein	protein	NOUN
gf06g161p9v	15	35	folding	fold	VERB
gf06g161p9v	15	36	as	as	SCONJ
gf06g161p9v	15	37	they	they	PRON
gf06g161p9v	15	38	are	be	AUX
gf06g161p9v	15	39	evolutionarily	evolutionarily	ADV
gf06g161p9v	15	40	conserved	conserve	VERB
gf06g161p9v	15	41	.	.	PUNCT
gf06g161p9v	16	1	we	we	PRON
gf06g161p9v	16	2	also	also	ADV
gf06g161p9v	16	3	describe	describe	VERB
gf06g161p9v	16	4	a	a	DET
gf06g161p9v	16	5	structure	structure	NOUN
gf06g161p9v	16	6	-	-	PUNCT
gf06g161p9v	16	7	based	base	VERB
gf06g161p9v	16	8	workflow	workflow	NOUN
gf06g161p9v	16	9	for	for	ADP
gf06g161p9v	16	10	the	the	DET
gf06g161p9v	16	11	identification	identification	NOUN
gf06g161p9v	16	12	of	of	ADP
gf06g161p9v	16	13	sidechain	sidechain	NOUN
gf06g161p9v	16	14	-	-	PUNCT
gf06g161p9v	16	15	to	to	ADP
gf06g161p9v	16	16	-	-	PUNCT
gf06g161p9v	16	17	backbone	backbone	NOUN
gf06g161p9v	16	18	hydrogen	hydrogen	NOUN
gf06g161p9v	16	19	bonds	bond	NOUN
gf06g161p9v	16	20	that	that	PRON
gf06g161p9v	16	21	reside	reside	VERB
gf06g161p9v	16	22	at	at	ADP
gf06g161p9v	16	23	protein	protein	NOUN
gf06g161p9v	16	24	-	-	PUNCT
gf06g161p9v	16	25	protein	protein	NOUN
gf06g161p9v	16	26	interfaces	interface	NOUN
gf06g161p9v	16	27	.	.	PUNCT
gf06g161p9v	17	1	this	this	DET
gf06g161p9v	17	2	work	work	NOUN
gf06g161p9v	17	3	lays	lay	VERB
gf06g161p9v	17	4	the	the	DET
gf06g161p9v	17	5	foundation	foundation	NOUN
gf06g161p9v	17	6	for	for	ADP
gf06g161p9v	17	7	future	future	ADJ
gf06g161p9v	17	8	synthetic	synthetic	ADJ
gf06g161p9v	17	9	endeavors	endeavor	NOUN
gf06g161p9v	17	10	to	to	PART
gf06g161p9v	17	11	study	study	VERB
gf06g161p9v	17	12	the	the	DET
gf06g161p9v	17	13	impact	impact	NOUN
gf06g161p9v	17	14	naprocycle	naprocycle	NOUN
gf06g161p9v	17	15	constraint	constraint	NOUN
gf06g161p9v	17	16	has	have	VERB
gf06g161p9v	17	17	on	on	ADP
gf06g161p9v	17	18	tertiary	tertiary	ADJ
gf06g161p9v	17	19	folding	folding	NOUN
gf06g161p9v	17	20	in	in	ADP
gf06g161p9v	17	21	miniproteins	miniprotein	NOUN
gf06g161p9v	17	22	and	and	CCONJ
gf06g161p9v	17	23	to	to	PART
gf06g161p9v	17	24	construct	construct	VERB
gf06g161p9v	17	25	minimized	minimized	ADJ
gf06g161p9v	17	26	binding	bind	VERB
gf06g161p9v	17	27	domains	domain	NOUN
gf06g161p9v	17	28	that	that	PRON
gf06g161p9v	17	29	target	target	VERB
gf06g161p9v	17	30	biologically	biologically	ADV
gf06g161p9v	17	31	relevant	relevant	ADJ
gf06g161p9v	17	32	protein	protein	NOUN
gf06g161p9v	17	33	-	-	PUNCT
gf06g161p9v	17	34	protein	protein	NOUN
gf06g161p9v	17	35	interactions.in	interactions.in	ADJ
gf06g161p9v	17	36	continuation	continuation	NOUN
gf06g161p9v	17	37	of	of	ADP
gf06g161p9v	17	38	our	our	PRON
gf06g161p9v	17	39	efforts	effort	NOUN
gf06g161p9v	17	40	toward	toward	ADP
gf06g161p9v	17	41	conformationally	conformationally	ADV
gf06g161p9v	17	42	defined	define	VERB
gf06g161p9v	17	43	and	and	CCONJ
gf06g161p9v	17	44	proteolytically	proteolytically	ADV
gf06g161p9v	17	45	stable	stable	ADJ
gf06g161p9v	17	46	peptidomimetics	peptidomimetic	NOUN
gf06g161p9v	17	47	,	,	PUNCT
gf06g161p9v	17	48	we	we	PRON
gf06g161p9v	17	49	explore	explore	VERB
gf06g161p9v	17	50	the	the	DET
gf06g161p9v	17	51	effect	effect	NOUN
gf06g161p9v	17	52	n	n	NOUN
gf06g161p9v	17	53	-	-	PUNCT
gf06g161p9v	17	54	amination	amination	NOUN
gf06g161p9v	17	55	has	have	VERB
gf06g161p9v	17	56	on	on	ADP
gf06g161p9v	17	57	the	the	DET
gf06g161p9v	17	58	structure	structure	NOUN
gf06g161p9v	17	59	and	and	CCONJ
gf06g161p9v	17	60	activity	activity	NOUN
gf06g161p9v	17	61	of	of	ADP
gf06g161p9v	17	62	a	a	DET
gf06g161p9v	17	63	β	β	NUM
gf06g161p9v	17	64	-	-	PUNCT
gf06g161p9v	17	65	sheet	sheet	NOUN
gf06g161p9v	17	66	model	model	NOUN
gf06g161p9v	17	67	system	system	NOUN
gf06g161p9v	17	68	.	.	PUNCT
gf06g161p9v	18	1	we	we	PRON
gf06g161p9v	18	2	demonstrate	demonstrate	VERB
gf06g161p9v	18	3	an	an	DET
gf06g161p9v	18	4	efficient	efficient	ADJ
gf06g161p9v	18	5	protocol	protocol	NOUN
gf06g161p9v	18	6	for	for	ADP
gf06g161p9v	18	7	the	the	DET
gf06g161p9v	18	8	synthesis	synthesis	NOUN
gf06g161p9v	18	9	of	of	ADP
gf06g161p9v	18	10	the	the	DET
gf06g161p9v	18	11	antimicrobial	antimicrobial	ADJ
gf06g161p9v	18	12	gramicidin	gramicidin	X
gf06g161p9v	18	13	s	s	PART
gf06g161p9v	18	14	and	and	CCONJ
gf06g161p9v	18	15	n	n	ADV
gf06g161p9v	18	16	-	-	ADJ
gf06g161p9v	18	17	aminated	aminated	ADJ
gf06g161p9v	18	18	analogues	analogue	NOUN
gf06g161p9v	18	19	thereof	thereof	ADV
gf06g161p9v	18	20	.	.	PUNCT
gf06g161p9v	19	1	we	we	PRON
gf06g161p9v	19	2	describe	describe	VERB
gf06g161p9v	19	3	the	the	DET
gf06g161p9v	19	4	parallel	parallel	ADJ
gf06g161p9v	19	5	synthesis	synthesis	NOUN
gf06g161p9v	19	6	of	of	ADP
gf06g161p9v	19	7	n	n	ADJ
gf06g161p9v	19	8	-	-	ADJ
gf06g161p9v	19	9	aminated	aminated	ADJ
gf06g161p9v	19	10	analogues	analogue	NOUN
gf06g161p9v	19	11	of	of	ADP
gf06g161p9v	19	12	gramicidin	gramicidin	PROPN
gf06g161p9v	19	13	s	s	PROPN
gf06g161p9v	19	14	via	via	ADP
gf06g161p9v	19	15	the	the	DET
gf06g161p9v	19	16	incorporation	incorporation	NOUN
gf06g161p9v	19	17	of	of	ADP
gf06g161p9v	19	18	n	n	ADJ
gf06g161p9v	19	19	-	-	PUNCT
gf06g161p9v	19	20	amino	amino	NOUN
gf06g161p9v	19	21	dipeptide	dipeptide	NOUN
gf06g161p9v	19	22	units	unit	NOUN
gf06g161p9v	19	23	on	on	ADP
gf06g161p9v	19	24	solid	solid	ADJ
gf06g161p9v	19	25	support	support	NOUN
gf06g161p9v	19	26	.	.	PUNCT
gf06g161p9v	20	1	compared	compare	VERB
gf06g161p9v	20	2	to	to	ADP
gf06g161p9v	20	3	gramicidin	gramicidin	PROPN
gf06g161p9v	20	4	s	s	PROPN
gf06g161p9v	20	5	,	,	PUNCT
gf06g161p9v	20	6	the	the	DET
gf06g161p9v	20	7	n	n	ADJ
gf06g161p9v	20	8	-	-	PUNCT
gf06g161p9v	20	9	aminated	aminated	ADJ
gf06g161p9v	20	10	analogues	analogue	NOUN
gf06g161p9v	20	11	show	show	NOUN
gf06g161p9v	20	12	reduced	reduce	VERB
gf06g161p9v	20	13	toxicity	toxicity	NOUN
gf06g161p9v	20	14	to	to	ADP
gf06g161p9v	20	15	human	human	ADJ
gf06g161p9v	20	16	red	red	ADJ
gf06g161p9v	20	17	blood	blood	NOUN
gf06g161p9v	20	18	cells	cell	NOUN
gf06g161p9v	20	19	and	and	CCONJ
gf06g161p9v	20	20	many	many	ADJ
gf06g161p9v	20	21	exhibit	exhibit	VERB
gf06g161p9v	20	22	similar	similar	ADJ
gf06g161p9v	20	23	or	or	CCONJ
gf06g161p9v	20	24	enhanced	enhanced	ADJ
gf06g161p9v	20	25	activity	activity	NOUN
gf06g161p9v	20	26	against	against	ADP
gf06g161p9v	20	27	a	a	DET
gf06g161p9v	20	28	panel	panel	NOUN
gf06g161p9v	20	29	of	of	ADP
gf06g161p9v	20	30	eskape	eskape	NOUN
gf06g161p9v	20	31	pathogens	pathogen	NOUN
gf06g161p9v	20	32	.	.	PUNCT
gf06g161p9v	21	1	our	our	PRON
gf06g161p9v	21	2	work	work	NOUN
gf06g161p9v	21	3	suggests	suggest	VERB
gf06g161p9v	21	4	that	that	SCONJ
gf06g161p9v	21	5	relative	relative	ADJ
gf06g161p9v	21	6	to	to	ADP
gf06g161p9v	21	7	gramicidin	gramicidin	PROPN
gf06g161p9v	21	8	s	s	PROPN
gf06g161p9v	21	9	,	,	PUNCT
gf06g161p9v	21	10	the	the	DET
gf06g161p9v	21	11	improved	improved	ADJ
gf06g161p9v	21	12	therapeutic	therapeutic	ADJ
gf06g161p9v	21	13	profile	profile	NOUN
gf06g161p9v	21	14	of	of	ADP
gf06g161p9v	21	15	n	n	ADJ
gf06g161p9v	21	16	-	-	ADJ
gf06g161p9v	21	17	aminated	aminated	ADJ
gf06g161p9v	21	18	analogues	analogue	NOUN
gf06g161p9v	21	19	may	may	AUX
gf06g161p9v	21	20	be	be	AUX
gf06g161p9v	21	21	due	due	ADJ
gf06g161p9v	21	22	to	to	ADP
gf06g161p9v	21	23	the	the	DET
gf06g161p9v	21	24	enhanced	enhanced	ADJ
gf06g161p9v	21	25	stability	stability	NOUN
gf06g161p9v	21	26	of	of	ADP
gf06g161p9v	21	27	the	the	DET
gf06g161p9v	21	28	β	β	NOUN
gf06g161p9v	21	29	-	-	PUNCT
gf06g161p9v	21	30	sheet	sheet	NOUN
gf06g161p9v	21	31	like	like	ADJ
gf06g161p9v	21	32	character	character	NOUN
gf06g161p9v	21	33	afforded	afford	VERB
gf06g161p9v	21	34	by	by	ADP
gf06g161p9v	21	35	the	the	DET
gf06g161p9v	21	36	conformational	conformational	ADJ
gf06g161p9v	21	37	constraints	constraint	NOUN
gf06g161p9v	21	38	imposed	impose	VERB
gf06g161p9v	21	39	by	by	ADP
gf06g161p9v	21	40	n	n	NOUN
gf06g161p9v	21	41	-	-	PUNCT
gf06g161p9v	21	42	amination	amination	NOUN
gf06g161p9v	21	43	.	.	PUNCT