id	sid	tid	token	lemma	pos
ff365427r23	1	1	1,25	1,25	NUM
ff365427r23	1	2	-	-	PUNCT
ff365427r23	1	3	dihydroxyvitamin	dihydroxyvitamin	NOUN
ff365427r23	1	4	d3	d3	PROPN
ff365427r23	1	5	(	(	PUNCT
ff365427r23	1	6	1,25d	1,25d	NUM
ff365427r23	1	7	)	)	PUNCT
ff365427r23	1	8	and	and	CCONJ
ff365427r23	1	9	its	its	PRON
ff365427r23	1	10	cognate	cognate	ADJ
ff365427r23	1	11	nuclear	nuclear	ADJ
ff365427r23	1	12	receptor	receptor	NOUN
ff365427r23	1	13	,	,	PUNCT
ff365427r23	1	14	the	the	DET
ff365427r23	1	15	vitamin	vitamin	NOUN
ff365427r23	1	16	d	d	NOUN
ff365427r23	1	17	receptor	receptor	NOUN
ff365427r23	1	18	(	(	PUNCT
ff365427r23	1	19	vdr	vdr	NOUN
ff365427r23	1	20	)	)	PUNCT
ff365427r23	1	21	,	,	PUNCT
ff365427r23	1	22	regulate	regulate	VERB
ff365427r23	1	23	calcium	calcium	NOUN
ff365427r23	1	24	homeostasis	homeostasis	NOUN
ff365427r23	1	25	via	via	ADP
ff365427r23	1	26	transcriptional	transcriptional	NOUN
ff365427r23	1	27	activation	activation	NOUN
ff365427r23	1	28	of	of	ADP
ff365427r23	1	29	target	target	NOUN
ff365427r23	1	30	genes	gene	NOUN
ff365427r23	1	31	.	.	PUNCT
ff365427r23	2	1	1,25d	1,25d	NUM
ff365427r23	2	2	is	be	AUX
ff365427r23	2	3	also	also	ADV
ff365427r23	2	4	known	know	VERB
ff365427r23	2	5	to	to	PART
ff365427r23	2	6	mediate	mediate	VERB
ff365427r23	2	7	growth	growth	NOUN
ff365427r23	2	8	arrest	arrest	NOUN
ff365427r23	2	9	and	and	CCONJ
ff365427r23	2	10	apoptosis	apoptosis	NOUN
ff365427r23	2	11	in	in	ADP
ff365427r23	2	12	a	a	DET
ff365427r23	2	13	variety	variety	NOUN
ff365427r23	2	14	of	of	ADP
ff365427r23	2	15	cancer	cancer	NOUN
ff365427r23	2	16	cell	cell	NOUN
ff365427r23	2	17	lines	line	NOUN
ff365427r23	2	18	and	and	CCONJ
ff365427r23	2	19	tumors	tumor	NOUN
ff365427r23	2	20	,	,	PUNCT
ff365427r23	2	21	however	however	ADV
ff365427r23	2	22	,	,	PUNCT
ff365427r23	2	23	the	the	DET
ff365427r23	2	24	role	role	NOUN
ff365427r23	2	25	of	of	ADP
ff365427r23	2	26	the	the	DET
ff365427r23	2	27	vdr	vdr	NOUN
ff365427r23	2	28	and	and	CCONJ
ff365427r23	2	29	the	the	DET
ff365427r23	2	30	role	role	NOUN
ff365427r23	2	31	of	of	ADP
ff365427r23	2	32	transcriptional	transcriptional	NOUN
ff365427r23	2	33	activation	activation	NOUN
ff365427r23	2	34	in	in	ADP
ff365427r23	2	35	this	this	DET
ff365427r23	2	36	process	process	NOUN
ff365427r23	2	37	remain	remain	VERB
ff365427r23	2	38	unclear	unclear	ADJ
ff365427r23	2	39	.	.	PUNCT
ff365427r23	3	1	to	to	PART
ff365427r23	3	2	investigate	investigate	VERB
ff365427r23	3	3	the	the	DET
ff365427r23	3	4	role	role	NOUN
ff365427r23	3	5	of	of	ADP
ff365427r23	3	6	the	the	DET
ff365427r23	3	7	vdr	vdr	NOUN
ff365427r23	3	8	in	in	ADP
ff365427r23	3	9	mediating	mediate	VERB
ff365427r23	3	10	the	the	DET
ff365427r23	3	11	anti	anti	ADJ
ff365427r23	3	12	-	-	ADJ
ff365427r23	3	13	cancer	cancer	ADJ
ff365427r23	3	14	properties	property	NOUN
ff365427r23	3	15	of	of	ADP
ff365427r23	3	16	1,25d	1,25d	NUM
ff365427r23	3	17	,	,	PUNCT
ff365427r23	3	18	two	two	NUM
ff365427r23	3	19	murine	murine	NOUN
ff365427r23	3	20	mammary	mammary	ADJ
ff365427r23	3	21	tumor	tumor	NOUN
ff365427r23	3	22	cell	cell	NOUN
ff365427r23	3	23	lines	line	NOUN
ff365427r23	3	24	with	with	ADP
ff365427r23	3	25	differential	differential	ADJ
ff365427r23	3	26	vdr	vdr	NOUN
ff365427r23	3	27	expression	expression	NOUN
ff365427r23	3	28	were	be	AUX
ff365427r23	3	29	characterized.wt145	characterized.wt145	NOUN
ff365427r23	3	30	cells	cell	NOUN
ff365427r23	3	31	,	,	PUNCT
ff365427r23	3	32	which	which	PRON
ff365427r23	3	33	express	express	VERB
ff365427r23	3	34	transcriptionally	transcriptionally	ADV
ff365427r23	3	35	functional	functional	ADJ
ff365427r23	3	36	vdr	vdr	NOUN
ff365427r23	3	37	protein	protein	NOUN
ff365427r23	3	38	,	,	PUNCT
ff365427r23	3	39	were	be	AUX
ff365427r23	3	40	growth	growth	NOUN
ff365427r23	3	41	inhibited	inhibit	VERB
ff365427r23	3	42	and	and	CCONJ
ff365427r23	3	43	rendered	render	VERB
ff365427r23	3	44	apoptotic	apoptotic	NOUN
ff365427r23	3	45	by	by	ADP
ff365427r23	3	46	1,25d	1,25d	NUM
ff365427r23	3	47	and	and	CCONJ
ff365427r23	3	48	synthetic	synthetic	ADJ
ff365427r23	3	49	vitamin	vitamin	NOUN
ff365427r23	3	50	d	d	NOUN
ff365427r23	3	51	analogs	analog	NOUN
ff365427r23	3	52	.	.	PUNCT
ff365427r23	4	1	in	in	ADP
ff365427r23	4	2	contrast	contrast	NOUN
ff365427r23	4	3	,	,	PUNCT
ff365427r23	4	4	ko240	ko240	PROPN
ff365427r23	4	5	cells	cell	NOUN
ff365427r23	4	6	,	,	PUNCT
ff365427r23	4	7	which	which	PRON
ff365427r23	4	8	express	express	VERB
ff365427r23	4	9	no	no	DET
ff365427r23	4	10	detectable	detectable	ADJ
ff365427r23	4	11	vdr	vdr	NOUN
ff365427r23	4	12	protein	protein	NOUN
ff365427r23	4	13	or	or	CCONJ
ff365427r23	4	14	mrna	mrna	PROPN
ff365427r23	4	15	,	,	PUNCT
ff365427r23	4	16	were	be	AUX
ff365427r23	4	17	neither	neither	CCONJ
ff365427r23	4	18	growth	growth	NOUN
ff365427r23	4	19	inhibited	inhibit	VERB
ff365427r23	4	20	nor	nor	CCONJ
ff365427r23	4	21	rendered	render	VERB
ff365427r23	4	22	apoptotic	apoptotic	NOUN
ff365427r23	4	23	by	by	ADP
ff365427r23	4	24	1,25d	1,25d	NUM
ff365427r23	4	25	,	,	PUNCT
ff365427r23	4	26	at	at	ADP
ff365427r23	4	27	doses	dose	NOUN
ff365427r23	4	28	as	as	ADV
ff365427r23	4	29	high	high	ADJ
ff365427r23	4	30	as	as	ADP
ff365427r23	4	31	1µ	1µ	NUM
ff365427r23	4	32	m.	m.	NOUN
ff365427r23	4	33	collectively	collectively	ADV
ff365427r23	4	34	,	,	PUNCT
ff365427r23	4	35	these	these	DET
ff365427r23	4	36	data	datum	NOUN
ff365427r23	4	37	indicate	indicate	VERB
ff365427r23	4	38	that	that	PRON
ff365427r23	4	39	functional	functional	ADJ
ff365427r23	4	40	vdr	vdr	NOUN
ff365427r23	4	41	protein	protein	NOUN
ff365427r23	4	42	is	be	AUX
ff365427r23	4	43	required	require	VERB
ff365427r23	4	44	for	for	ADP
ff365427r23	4	45	the	the	DET
ff365427r23	4	46	anti	anti	ADJ
ff365427r23	4	47	-	-	ADJ
ff365427r23	4	48	cancer	cancer	ADJ
ff365427r23	4	49	effects	effect	NOUN
ff365427r23	4	50	of	of	ADP
ff365427r23	4	51	1,25d	1,25d	NUM
ff365427r23	4	52	and	and	CCONJ
ff365427r23	4	53	structurally	structurally	ADV
ff365427r23	4	54	related	relate	VERB
ff365427r23	4	55	vitamin	vitamin	NOUN
ff365427r23	4	56	d	d	NOUN
ff365427r23	4	57	based	base	VERB
ff365427r23	4	58	therapeutics	therapeutic	NOUN
ff365427r23	4	59	in	in	ADP
ff365427r23	4	60	vitro.to	vitro.to	NUM
ff365427r23	4	61	determine	determine	VERB
ff365427r23	4	62	whether	whether	SCONJ
ff365427r23	4	63	the	the	DET
ff365427r23	4	64	anti	anti	ADJ
ff365427r23	4	65	-	-	ADJ
ff365427r23	4	66	cancer	cancer	ADJ
ff365427r23	4	67	actions	action	NOUN
ff365427r23	4	68	of	of	ADP
ff365427r23	4	69	vitamin	vitamin	NOUN
ff365427r23	4	70	d	d	NOUN
ff365427r23	4	71	are	be	AUX
ff365427r23	4	72	mediated	mediate	VERB
ff365427r23	4	73	via	via	ADP
ff365427r23	4	74	the	the	DET
ff365427r23	4	75	vdr	vdr	NOUN
ff365427r23	4	76	in	in	ADP
ff365427r23	4	77	vivo	vivo	PROPN
ff365427r23	4	78	,	,	PUNCT
ff365427r23	4	79	nude	nude	ADJ
ff365427r23	4	80	mice	mouse	NOUN
ff365427r23	4	81	bearing	bear	VERB
ff365427r23	4	82	tumors	tumor	NOUN
ff365427r23	4	83	derived	derive	VERB
ff365427r23	4	84	from	from	ADP
ff365427r23	4	85	wt145	wt145	PROPN
ff365427r23	4	86	or	or	CCONJ
ff365427r23	4	87	ko240	ko240	PROPN
ff365427r23	4	88	cells	cell	NOUN
ff365427r23	4	89	were	be	AUX
ff365427r23	4	90	treated	treat	VERB
ff365427r23	4	91	with	with	ADP
ff365427r23	4	92	eb1089	eb1089	PROPN
ff365427r23	4	93	,	,	PUNCT
ff365427r23	4	94	a	a	DET
ff365427r23	4	95	synthetic	synthetic	ADJ
ff365427r23	4	96	analog	analog	NOUN
ff365427r23	4	97	of	of	ADP
ff365427r23	4	98	1,25d	1,25d	NUM
ff365427r23	4	99	,	,	PUNCT
ff365427r23	4	100	or	or	CCONJ
ff365427r23	4	101	placebo	placebo	NOUN
ff365427r23	4	102	for	for	ADP
ff365427r23	4	103	six	six	NUM
ff365427r23	4	104	weeks	week	NOUN
ff365427r23	4	105	.	.	PUNCT
ff365427r23	5	1	an	an	DET
ff365427r23	5	2	untreated	untreated	ADJ
ff365427r23	5	3	subset	subset	NOUN
ff365427r23	5	4	of	of	ADP
ff365427r23	5	5	tumor	tumor	NOUN
ff365427r23	5	6	-	-	PUNCT
ff365427r23	5	7	bearing	bear	VERB
ff365427r23	5	8	mice	mouse	NOUN
ff365427r23	5	9	was	be	AUX
ff365427r23	5	10	exposed	expose	VERB
ff365427r23	5	11	to	to	ADP
ff365427r23	5	12	ultraviolet	ultraviolet	NOUN
ff365427r23	5	13	(	(	PUNCT
ff365427r23	5	14	uv	uv	NOUN
ff365427r23	5	15	)	)	PUNCT
ff365427r23	5	16	light	light	NOUN
ff365427r23	5	17	,	,	PUNCT
ff365427r23	5	18	to	to	PART
ff365427r23	5	19	activate	activate	VERB
ff365427r23	5	20	endogenous	endogenous	ADJ
ff365427r23	5	21	1,25d	1,25d	NUM
ff365427r23	5	22	production	production	NOUN
ff365427r23	5	23	.	.	PUNCT
ff365427r23	6	1	both	both	CCONJ
ff365427r23	6	2	eb1089	eb1089	ADJ
ff365427r23	6	3	and	and	CCONJ
ff365427r23	6	4	uv	uv	NOUN
ff365427r23	6	5	light	light	NOUN
ff365427r23	6	6	exposure	exposure	NOUN
ff365427r23	6	7	decreased	decrease	VERB
ff365427r23	6	8	volume	volume	NOUN
ff365427r23	6	9	of	of	ADP
ff365427r23	6	10	wt145	wt145	PROPN
ff365427r23	6	11	tumors	tumor	NOUN
ff365427r23	6	12	through	through	ADP
ff365427r23	6	13	decreased	decrease	VERB
ff365427r23	6	14	tumor	tumor	NOUN
ff365427r23	6	15	cell	cell	NOUN
ff365427r23	6	16	proliferation	proliferation	NOUN
ff365427r23	6	17	and	and	CCONJ
ff365427r23	6	18	increased	increase	VERB
ff365427r23	6	19	tumor	tumor	NOUN
ff365427r23	6	20	cell	cell	NOUN
ff365427r23	6	21	apoptosis	apoptosis	NOUN
ff365427r23	6	22	.	.	PUNCT
ff365427r23	7	1	no	no	DET
ff365427r23	7	2	effects	effect	NOUN
ff365427r23	7	3	of	of	ADP
ff365427r23	7	4	either	either	CCONJ
ff365427r23	7	5	eb1089	eb1089	ADJ
ff365427r23	7	6	or	or	CCONJ
ff365427r23	7	7	uv	uv	NOUN
ff365427r23	7	8	treatments	treatment	NOUN
ff365427r23	7	9	were	be	AUX
ff365427r23	7	10	observed	observe	VERB
ff365427r23	7	11	in	in	ADP
ff365427r23	7	12	ko240	ko240	PROPN
ff365427r23	7	13	tumors	tumor	NOUN
ff365427r23	7	14	,	,	PUNCT
ff365427r23	7	15	indicating	indicate	VERB
ff365427r23	7	16	that	that	SCONJ
ff365427r23	7	17	the	the	DET
ff365427r23	7	18	vitamin	vitamin	NOUN
ff365427r23	7	19	d	d	NOUN
ff365427r23	7	20	pathway	pathway	NOUN
ff365427r23	7	21	mediates	mediate	VERB
ff365427r23	7	22	its	its	PRON
ff365427r23	7	23	anti	anti	ADJ
ff365427r23	7	24	-	-	ADJ
ff365427r23	7	25	tumor	tumor	ADJ
ff365427r23	7	26	effects	effect	NOUN
ff365427r23	7	27	in	in	ADP
ff365427r23	7	28	vivo	vivo	PROPN
ff365427r23	7	29	via	via	ADP
ff365427r23	7	30	tumor	tumor	NOUN
ff365427r23	7	31	-	-	PUNCT
ff365427r23	7	32	cell	cell	NOUN
ff365427r23	7	33	vdr.ko240	vdr.ko240	NOUN
ff365427r23	7	34	cells	cell	NOUN
ff365427r23	7	35	stably	stably	ADV
ff365427r23	7	36	expressing	express	VERB
ff365427r23	7	37	wild	wild	ADJ
ff365427r23	7	38	-	-	PUNCT
ff365427r23	7	39	type	type	NOUN
ff365427r23	7	40	vdr	vdr	NOUN
ff365427r23	7	41	and	and	CCONJ
ff365427r23	7	42	vdr	vdr	NOUN
ff365427r23	7	43	point	point	NOUN
ff365427r23	7	44	mutants	mutant	VERB
ff365427r23	7	45	from	from	ADP
ff365427r23	7	46	hereditary	hereditary	ADJ
ff365427r23	7	47	rickets	ricket	NOUN
ff365427r23	7	48	patients	patient	NOUN
ff365427r23	7	49	were	be	AUX
ff365427r23	7	50	created	create	VERB
ff365427r23	7	51	and	and	CCONJ
ff365427r23	7	52	characterized	characterize	VERB
ff365427r23	7	53	,	,	PUNCT
ff365427r23	7	54	to	to	PART
ff365427r23	7	55	further	far	ADV
ff365427r23	7	56	examine	examine	VERB
ff365427r23	7	57	the	the	DET
ff365427r23	7	58	mechanism	mechanism	NOUN
ff365427r23	7	59	of	of	ADP
ff365427r23	7	60	vdr	vdr	NOUN
ff365427r23	7	61	in	in	ADP
ff365427r23	7	62	growth	growth	NOUN
ff365427r23	7	63	regulation	regulation	NOUN
ff365427r23	7	64	.	.	PUNCT
ff365427r23	8	1	ko	ko	PROPN
ff365427r23	8	2	cells	cell	NOUN
ff365427r23	8	3	stably	stably	ADV
ff365427r23	8	4	expressing	express	VERB
ff365427r23	8	5	vdr	vdr	NOUN
ff365427r23	8	6	were	be	AUX
ff365427r23	8	7	growth	growth	NOUN
ff365427r23	8	8	inhibited	inhibit	VERB
ff365427r23	8	9	by	by	ADP
ff365427r23	8	10	1,25d	1,25d	NUM
ff365427r23	8	11	and	and	CCONJ
ff365427r23	8	12	its	its	PRON
ff365427r23	8	13	structural	structural	ADJ
ff365427r23	8	14	analogs	analog	NOUN
ff365427r23	8	15	,	,	PUNCT
ff365427r23	8	16	indicating	indicate	VERB
ff365427r23	8	17	that	that	SCONJ
ff365427r23	8	18	the	the	DET
ff365427r23	8	19	vitamin	vitamin	NOUN
ff365427r23	8	20	d	d	NOUN
ff365427r23	8	21	growth	growth	NOUN
ff365427r23	8	22	regulatory	regulatory	ADJ
ff365427r23	8	23	pathway	pathway	NOUN
ff365427r23	8	24	could	could	AUX
ff365427r23	8	25	be	be	AUX
ff365427r23	8	26	reconstituted	reconstitute	VERB
ff365427r23	8	27	in	in	ADP
ff365427r23	8	28	vdr	vdr	NOUN
ff365427r23	8	29	null	null	ADJ
ff365427r23	8	30	cells	cell	NOUN
ff365427r23	8	31	.	.	PUNCT
ff365427r23	9	1	cells	cell	NOUN
ff365427r23	9	2	expressing	express	VERB
ff365427r23	9	3	mutant	mutant	ADJ
ff365427r23	9	4	vdrs	vdr	NOUN
ff365427r23	9	5	were	be	AUX
ff365427r23	9	6	differentially	differentially	ADV
ff365427r23	9	7	affected	affect	VERB
ff365427r23	9	8	by	by	ADP
ff365427r23	9	9	1,25d	1,25d	NUM
ff365427r23	9	10	and	and	CCONJ
ff365427r23	9	11	analogs	analog	NOUN
ff365427r23	9	12	;	;	PUNCT
ff365427r23	9	13	vdr	vdr	NOUN
ff365427r23	9	14	that	that	PRON
ff365427r23	9	15	lack	lack	VERB
ff365427r23	9	16	dna	dna	PROPN
ff365427r23	9	17	binding	bind	VERB
ff365427r23	9	18	ability	ability	NOUN
ff365427r23	9	19	were	be	AUX
ff365427r23	9	20	growth	growth	NOUN
ff365427r23	9	21	inhibited	inhibit	VERB
ff365427r23	9	22	by	by	ADP
ff365427r23	9	23	physiological	physiological	ADJ
ff365427r23	9	24	doses	dose	NOUN
ff365427r23	9	25	of	of	ADP
ff365427r23	9	26	1,25d	1,25d	NUM
ff365427r23	9	27	while	while	SCONJ
ff365427r23	9	28	ligand	ligand	NOUN
ff365427r23	9	29	binding	bind	VERB
ff365427r23	9	30	domain	domain	NOUN
ff365427r23	9	31	mutants	mutant	NOUN
ff365427r23	9	32	were	be	AUX
ff365427r23	9	33	not	not	PART
ff365427r23	9	34	.	.	PUNCT
ff365427r23	10	1	this	this	PRON
ff365427r23	10	2	suggests	suggest	VERB
ff365427r23	10	3	that	that	SCONJ
ff365427r23	10	4	the	the	DET
ff365427r23	10	5	anti	anti	ADJ
ff365427r23	10	6	-	-	ADJ
ff365427r23	10	7	cancer	cancer	ADJ
ff365427r23	10	8	effects	effect	NOUN
ff365427r23	10	9	of	of	ADP
ff365427r23	10	10	1,25d	1,25d	NUM
ff365427r23	10	11	,	,	PUNCT
ff365427r23	10	12	while	while	SCONJ
ff365427r23	10	13	vdr	vdr	NOUN
ff365427r23	10	14	mediated	mediate	VERB
ff365427r23	10	15	,	,	PUNCT
ff365427r23	10	16	are	be	AUX
ff365427r23	10	17	in	in	ADP
ff365427r23	10	18	part	part	NOUN
ff365427r23	10	19	mediated	mediate	VERB
ff365427r23	10	20	via	via	ADP
ff365427r23	10	21	novel	novel	NOUN
ff365427r23	10	22	,	,	PUNCT
ff365427r23	10	23	dna	dna	PROPN
ff365427r23	10	24	-	-	PUNCT
ff365427r23	10	25	independent	independent	ADJ
ff365427r23	10	26	mechanisms	mechanism	NOUN
ff365427r23	10	27	.	.	PUNCT