id	sid	tid	token	lemma	pos
fb494744f63	1	1	the	the	DET
fb494744f63	1	2	aortic	aortic	NOUN
fb494744f63	1	3	valve	valve	NOUN
fb494744f63	1	4	(	(	PUNCT
fb494744f63	1	5	av	av	PROPN
fb494744f63	1	6	)	)	PUNCT
fb494744f63	1	7	ensures	ensure	VERB
fb494744f63	1	8	unidirectional	unidirectional	ADJ
fb494744f63	1	9	flow	flow	NOUN
fb494744f63	1	10	between	between	ADP
fb494744f63	1	11	the	the	DET
fb494744f63	1	12	left	left	ADJ
fb494744f63	1	13	ventricle	ventricle	NOUN
fb494744f63	1	14	and	and	CCONJ
fb494744f63	1	15	the	the	DET
fb494744f63	1	16	aorta	aorta	NOUN
fb494744f63	1	17	by	by	ADP
fb494744f63	1	18	opening	open	VERB
fb494744f63	1	19	during	during	ADP
fb494744f63	1	20	cardiac	cardiac	ADJ
fb494744f63	1	21	systole	systole	NOUN
fb494744f63	1	22	and	and	CCONJ
fb494744f63	1	23	closing	close	VERB
fb494744f63	1	24	during	during	ADP
fb494744f63	1	25	diastole	diastole	NOUN
fb494744f63	1	26	.	.	PUNCT
fb494744f63	2	1	as	as	SCONJ
fb494744f63	2	2	compared	compare	VERB
fb494744f63	2	3	to	to	ADP
fb494744f63	2	4	the	the	DET
fb494744f63	2	5	normal	normal	ADJ
fb494744f63	2	6	tricuspid	tricuspid	NOUN
fb494744f63	2	7	aortic	aortic	NOUN
fb494744f63	2	8	valve	valve	NOUN
fb494744f63	2	9	(	(	PUNCT
fb494744f63	2	10	tav	tav	PROPN
fb494744f63	2	11	)	)	PUNCT
fb494744f63	2	12	anatomy	anatomy	NOUN
fb494744f63	2	13	,	,	PUNCT
fb494744f63	2	14	which	which	PRON
fb494744f63	2	15	consists	consist	VERB
fb494744f63	2	16	of	of	ADP
fb494744f63	2	17	three	three	NUM
fb494744f63	2	18	leaflets	leaflet	NOUN
fb494744f63	2	19	,	,	PUNCT
fb494744f63	2	20	the	the	DET
fb494744f63	2	21	bicuspid	bicuspid	NOUN
fb494744f63	2	22	aortic	aortic	NOUN
fb494744f63	2	23	valve	valve	NOUN
fb494744f63	2	24	(	(	PUNCT
fb494744f63	2	25	bav	bav	NOUN
fb494744f63	2	26	)	)	PUNCT
fb494744f63	2	27	is	be	AUX
fb494744f63	2	28	characterized	characterize	VERB
fb494744f63	2	29	by	by	ADP
fb494744f63	2	30	the	the	DET
fb494744f63	2	31	presence	presence	NOUN
fb494744f63	2	32	of	of	ADP
fb494744f63	2	33	two	two	NUM
fb494744f63	2	34	leaflets	leaflet	NOUN
fb494744f63	2	35	,	,	PUNCT
fb494744f63	2	36	and	and	CCONJ
fb494744f63	2	37	is	be	AUX
fb494744f63	2	38	the	the	DET
fb494744f63	2	39	most	most	ADV
fb494744f63	2	40	prevalent	prevalent	ADJ
fb494744f63	2	41	congenital	congenital	ADJ
fb494744f63	2	42	cardiac	cardiac	ADJ
fb494744f63	2	43	anomaly	anomaly	PROPN
fb494744f63	2	44	.	.	PUNCT
fb494744f63	3	1	regardless	regardless	ADV
fb494744f63	3	2	of	of	ADP
fb494744f63	3	3	the	the	DET
fb494744f63	3	4	valve	valve	NOUN
fb494744f63	3	5	morphology	morphology	NOUN
fb494744f63	3	6	,	,	PUNCT
fb494744f63	3	7	a	a	DET
fb494744f63	3	8	common	common	ADJ
fb494744f63	3	9	cause	cause	NOUN
fb494744f63	3	10	of	of	ADP
fb494744f63	3	11	valvular	valvular	ADJ
fb494744f63	3	12	failure	failure	NOUN
fb494744f63	3	13	is	be	AUX
fb494744f63	3	14	calcific	calcific	ADJ
fb494744f63	3	15	aortic	aortic	NOUN
fb494744f63	3	16	valve	valve	NOUN
fb494744f63	3	17	disease	disease	NOUN
fb494744f63	3	18	(	(	PUNCT
fb494744f63	3	19	cavd	cavd	NOUN
fb494744f63	3	20	)	)	PUNCT
fb494744f63	3	21	,	,	PUNCT
fb494744f63	3	22	a	a	DET
fb494744f63	3	23	condition	condition	NOUN
fb494744f63	3	24	characterized	characterize	VERB
fb494744f63	3	25	by	by	ADP
fb494744f63	3	26	increased	increase	VERB
fb494744f63	3	27	thickness	thickness	NOUN
fb494744f63	3	28	and	and	CCONJ
fb494744f63	3	29	stiffness	stiffness	NOUN
fb494744f63	3	30	on	on	ADP
fb494744f63	3	31	the	the	DET
fb494744f63	3	32	valve	valve	NOUN
fb494744f63	3	33	leaflets	leaflet	NOUN
fb494744f63	3	34	.	.	PUNCT
fb494744f63	4	1	historically	historically	ADV
fb494744f63	4	2	,	,	PUNCT
fb494744f63	4	3	cavd	cavd	NOUN
fb494744f63	4	4	has	have	AUX
fb494744f63	4	5	been	be	AUX
fb494744f63	4	6	considered	consider	VERB
fb494744f63	4	7	a	a	DET
fb494744f63	4	8	passive	passive	ADJ
fb494744f63	4	9	degenerative	degenerative	ADJ
fb494744f63	4	10	disease	disease	NOUN
fb494744f63	4	11	but	but	CCONJ
fb494744f63	4	12	is	be	AUX
fb494744f63	4	13	now	now	ADV
fb494744f63	4	14	recognized	recognize	VERB
fb494744f63	4	15	as	as	ADP
fb494744f63	4	16	an	an	DET
fb494744f63	4	17	active	active	ADJ
fb494744f63	4	18	pathology	pathology	NOUN
fb494744f63	4	19	involving	involve	VERB
fb494744f63	4	20	inflammation	inflammation	NOUN
fb494744f63	4	21	,	,	PUNCT
fb494744f63	4	22	remodeling	remodeling	NOUN
fb494744f63	4	23	and	and	CCONJ
fb494744f63	4	24	ossification	ossification	NOUN
fb494744f63	4	25	and	and	CCONJ
fb494744f63	4	26	presumably	presumably	ADV
fb494744f63	4	27	triggered	trigger	VERB
fb494744f63	4	28	by	by	ADP
fb494744f63	4	29	atherogenic	atherogenic	ADJ
fb494744f63	4	30	risk	risk	NOUN
fb494744f63	4	31	factors	factor	NOUN
fb494744f63	4	32	and	and	CCONJ
fb494744f63	4	33	hemodynamic	hemodynamic	ADJ
fb494744f63	4	34	cues	cue	NOUN
fb494744f63	4	35	.	.	PUNCT
fb494744f63	5	1	while	while	SCONJ
fb494744f63	5	2	tav	tav	PROPN
fb494744f63	5	3	and	and	CCONJ
fb494744f63	5	4	bav	bav	NOUN
fb494744f63	5	5	calcification	calcification	NOUN
fb494744f63	5	6	seem	seem	VERB
fb494744f63	5	7	to	to	PART
fb494744f63	5	8	share	share	VERB
fb494744f63	5	9	common	common	ADJ
fb494744f63	5	10	biological	biological	ADJ
fb494744f63	5	11	pathways	pathway	NOUN
fb494744f63	5	12	,	,	PUNCT
fb494744f63	5	13	the	the	DET
fb494744f63	5	14	calcification	calcification	NOUN
fb494744f63	5	15	of	of	ADP
fb494744f63	5	16	the	the	DET
fb494744f63	5	17	bav	bav	NOUN
fb494744f63	5	18	is	be	AUX
fb494744f63	5	19	more	more	ADV
fb494744f63	5	20	rapid	rapid	ADJ
fb494744f63	5	21	and	and	CCONJ
fb494744f63	5	22	severe	severe	ADJ
fb494744f63	5	23	than	than	ADP
fb494744f63	5	24	the	the	DET
fb494744f63	5	25	tav	tav	PROPN
fb494744f63	5	26	.	.	PUNCT
fb494744f63	6	1	as	as	SCONJ
fb494744f63	6	2	evidenced	evidence	VERB
fb494744f63	6	3	by	by	ADP
fb494744f63	6	4	recent	recent	ADJ
fb494744f63	6	5	studies	study	NOUN
fb494744f63	6	6	,	,	PUNCT
fb494744f63	6	7	the	the	DET
fb494744f63	6	8	valve	valve	NOUN
fb494744f63	6	9	interacts	interact	VERB
fb494744f63	6	10	closely	closely	ADV
fb494744f63	6	11	with	with	ADP
fb494744f63	6	12	its	its	PRON
fb494744f63	6	13	surrounding	surround	VERB
fb494744f63	6	14	hemodynamic	hemodynamic	ADJ
fb494744f63	6	15	environment	environment	NOUN
fb494744f63	6	16	to	to	PART
fb494744f63	6	17	maintain	maintain	VERB
fb494744f63	6	18	valvular	valvular	ADJ
fb494744f63	6	19	homeostasis	homeostasis	NOUN
fb494744f63	6	20	by	by	ADP
fb494744f63	6	21	altering	alter	VERB
fb494744f63	6	22	the	the	DET
fb494744f63	6	23	biosynthetic	biosynthetic	ADJ
fb494744f63	6	24	behavior	behavior	NOUN
fb494744f63	6	25	of	of	ADP
fb494744f63	6	26	valve	valve	NOUN
fb494744f63	6	27	cells	cell	NOUN
fb494744f63	6	28	.	.	PUNCT
fb494744f63	7	1	physiologic	physiologic	ADJ
fb494744f63	7	2	fluid	fluid	ADJ
fb494744f63	7	3	shear	shear	NOUN
fb494744f63	7	4	stress	stress	NOUN
fb494744f63	7	5	(	(	PUNCT
fb494744f63	7	6	fss	fss	NOUN
fb494744f63	7	7	)	)	PUNCT
fb494744f63	7	8	,	,	PUNCT
fb494744f63	7	9	the	the	DET
fb494744f63	7	10	frictional	frictional	ADJ
fb494744f63	7	11	fluid	fluid	ADJ
fb494744f63	7	12	force	force	NOUN
fb494744f63	7	13	acting	act	VERB
fb494744f63	7	14	on	on	ADP
fb494744f63	7	15	the	the	DET
fb494744f63	7	16	leaflet	leaflet	PROPN
fb494744f63	7	17	endothelium	endothelium	NOUN
fb494744f63	7	18	,	,	PUNCT
fb494744f63	7	19	contributes	contribute	VERB
fb494744f63	7	20	to	to	ADP
fb494744f63	7	21	valvular	valvular	ADJ
fb494744f63	7	22	homeostasis	homeostasis	NOUN
fb494744f63	7	23	by	by	ADP
fb494744f63	7	24	regulating	regulate	VERB
fb494744f63	7	25	valvular	valvular	ADJ
fb494744f63	7	26	protein	protein	NOUN
fb494744f63	7	27	expression	expression	NOUN
fb494744f63	7	28	,	,	PUNCT
fb494744f63	7	29	glycosaminoglycan	glycosaminoglycan	NOUN
fb494744f63	7	30	and	and	CCONJ
fb494744f63	7	31	dna	dna	PROPN
fb494744f63	7	32	synthesis	synthesis	NOUN
fb494744f63	7	33	and	and	CCONJ
fb494744f63	7	34	endothelial	endothelial	ADJ
fb494744f63	7	35	cell	cell	NOUN
fb494744f63	7	36	alignment	alignment	NOUN
fb494744f63	7	37	.	.	PUNCT
fb494744f63	8	1	in	in	ADP
fb494744f63	8	2	contrast	contrast	NOUN
fb494744f63	8	3	,	,	PUNCT
fb494744f63	8	4	fss	fss	ADJ
fb494744f63	8	5	abnormalities	abnormality	NOUN
fb494744f63	8	6	have	have	AUX
fb494744f63	8	7	been	be	AUX
fb494744f63	8	8	shown	show	VERB
fb494744f63	8	9	to	to	PART
fb494744f63	8	10	promote	promote	VERB
fb494744f63	8	11	endothelial	endothelial	ADJ
fb494744f63	8	12	activation	activation	NOUN
fb494744f63	8	13	and	and	CCONJ
fb494744f63	8	14	leaflet	leaflet	PROPN
fb494744f63	8	15	inflammation	inflammation	NOUN
fb494744f63	8	16	.	.	PUNCT
fb494744f63	9	1	supported	support	VERB
fb494744f63	9	2	by	by	ADP
fb494744f63	9	3	those	those	DET
fb494744f63	9	4	observations	observation	NOUN
fb494744f63	9	5	,	,	PUNCT
fb494744f63	9	6	the	the	DET
fb494744f63	9	7	central	central	ADJ
fb494744f63	9	8	hypothesis	hypothesis	NOUN
fb494744f63	9	9	of	of	ADP
fb494744f63	9	10	this	this	DET
fb494744f63	9	11	thesis	thesis	NOUN
fb494744f63	9	12	is	be	AUX
fb494744f63	9	13	that	that	SCONJ
fb494744f63	9	14	hemodynamic	hemodynamic	ADJ
fb494744f63	9	15	fss	fss	ADJ
fb494744f63	9	16	abnormalities	abnormality	NOUN
fb494744f63	9	17	contribute	contribute	VERB
fb494744f63	9	18	to	to	ADP
fb494744f63	9	19	cavd	cavd	NOUN
fb494744f63	9	20	development	development	NOUN
fb494744f63	9	21	by	by	ADP
fb494744f63	9	22	regulating	regulate	VERB
fb494744f63	9	23	av	av	NOUN
fb494744f63	9	24	inflammation	inflammation	NOUN
fb494744f63	9	25	,	,	PUNCT
fb494744f63	9	26	extracellular	extracellular	ADJ
fb494744f63	9	27	matrix	matrix	NOUN
fb494744f63	9	28	remodeling	remodeling	NOUN
fb494744f63	9	29	and	and	CCONJ
fb494744f63	9	30	valvular	valvular	ADJ
fb494744f63	9	31	osteogenesis	osteogenesis	NOUN
fb494744f63	9	32	.	.	PUNCT
fb494744f63	10	1	therefore	therefore	ADV
fb494744f63	10	2	,	,	PUNCT
fb494744f63	10	3	the	the	DET
fb494744f63	10	4	overall	overall	ADJ
fb494744f63	10	5	goal	goal	NOUN
fb494744f63	10	6	of	of	ADP
fb494744f63	10	7	this	this	DET
fb494744f63	10	8	work	work	NOUN
fb494744f63	10	9	is	be	AUX
fb494744f63	10	10	to	to	PART
fb494744f63	10	11	characterize	characterize	VERB
fb494744f63	10	12	the	the	DET
fb494744f63	10	13	role	role	NOUN
fb494744f63	10	14	of	of	ADP
fb494744f63	10	15	fss	fss	ADJ
fb494744f63	10	16	abnormalities	abnormality	NOUN
fb494744f63	10	17	on	on	ADP
fb494744f63	10	18	early	early	ADJ
fb494744f63	10	19	progression	progression	NOUN
fb494744f63	10	20	of	of	ADP
fb494744f63	10	21	cavd	cavd	NOUN
fb494744f63	10	22	in	in	ADP
fb494744f63	10	23	both	both	DET
fb494744f63	10	24	tavs	tavs	NOUN
fb494744f63	10	25	and	and	CCONJ
fb494744f63	10	26	bavs	bavs	PROPN
fb494744f63	10	27	.	.	PUNCT
fb494744f63	11	1	specifically	specifically	ADV
fb494744f63	11	2	,	,	PUNCT
fb494744f63	11	3	this	this	DET
fb494744f63	11	4	thesis	thesis	NOUN
fb494744f63	11	5	will	will	AUX
fb494744f63	11	6	address	address	VERB
fb494744f63	11	7	the	the	DET
fb494744f63	11	8	following	follow	VERB
fb494744f63	11	9	research	research	NOUN
fb494744f63	11	10	questions	question	NOUN
fb494744f63	11	11	:	:	PUNCT
fb494744f63	11	12	1	1	X
fb494744f63	11	13	)	)	PUNCT
fb494744f63	11	14	what	what	PRON
fb494744f63	11	15	are	be	AUX
fb494744f63	11	16	the	the	DET
fb494744f63	11	17	mechanisms	mechanism	NOUN
fb494744f63	11	18	by	by	ADP
fb494744f63	11	19	which	which	PRON
fb494744f63	11	20	fss	fss	ADJ
fb494744f63	11	21	alterations	alteration	NOUN
fb494744f63	11	22	are	be	AUX
fb494744f63	11	23	transduced	transduce	VERB
fb494744f63	11	24	into	into	ADP
fb494744f63	11	25	valvular	valvular	ADJ
fb494744f63	11	26	pathological	pathological	ADJ
fb494744f63	11	27	responses	response	NOUN
fb494744f63	11	28	?	?	PUNCT
fb494744f63	12	1	2	2	X
fb494744f63	12	2	)	)	PUNCT
fb494744f63	12	3	are	be	AUX
fb494744f63	12	4	bmp-4	bmp-4	PRON
fb494744f63	12	5	and	and	CCONJ
fb494744f63	12	6	tgf-β1	tgf-β1	NUM
fb494744f63	12	7	potential	potential	ADJ
fb494744f63	12	8	target	target	NOUN
fb494744f63	12	9	molecules	molecule	NOUN
fb494744f63	12	10	for	for	ADP
fb494744f63	12	11	the	the	DET
fb494744f63	12	12	pharmacological	pharmacological	ADJ
fb494744f63	12	13	treatment	treatment	NOUN
fb494744f63	12	14	of	of	ADP
fb494744f63	12	15	cavd	cavd	NOUN
fb494744f63	12	16	?	?	PUNCT
fb494744f63	13	1	and	and	CCONJ
fb494744f63	13	2	3	3	X
fb494744f63	13	3	)	)	PUNCT
fb494744f63	13	4	what	what	PRON
fb494744f63	13	5	are	be	AUX
fb494744f63	13	6	the	the	DET
fb494744f63	13	7	reasons	reason	NOUN
fb494744f63	13	8	for	for	ADP
fb494744f63	13	9	the	the	DET
fb494744f63	13	10	early	early	ADJ
fb494744f63	13	11	development	development	NOUN
fb494744f63	13	12	and	and	CCONJ
fb494744f63	13	13	severity	severity	NOUN
fb494744f63	13	14	of	of	ADP
fb494744f63	13	15	bav	bav	NOUN
fb494744f63	13	16	calcification	calcification	NOUN
fb494744f63	13	17	?	?	PUNCT
fb494744f63	14	1	these	these	DET
fb494744f63	14	2	questions	question	NOUN
fb494744f63	14	3	will	will	AUX
fb494744f63	14	4	be	be	AUX
fb494744f63	14	5	addressed	address	VERB
fb494744f63	14	6	via	via	ADP
fb494744f63	14	7	three	three	NUM
fb494744f63	14	8	specific	specific	ADJ
fb494744f63	14	9	aims	aim	NOUN
fb494744f63	14	10	.	.	PUNCT
fb494744f63	15	1	1	1	X
fb494744f63	15	2	)	)	PUNCT
fb494744f63	15	3	to	to	PART
fb494744f63	15	4	elucidate	elucidate	VERB
fb494744f63	15	5	the	the	DET
fb494744f63	15	6	mechanisms	mechanism	NOUN
fb494744f63	15	7	of	of	ADP
fb494744f63	15	8	cavd	cavd	NOUN
fb494744f63	15	9	secondary	secondary	ADJ
fb494744f63	15	10	to	to	ADP
fb494744f63	15	11	fss	fss	ADJ
fb494744f63	15	12	magnitude	magnitude	NOUN
fb494744f63	15	13	&	&	CCONJ
fb494744f63	15	14	frequency	frequency	NOUN
fb494744f63	15	15	abnormalities	abnormality	NOUN
fb494744f63	15	16	;	;	PUNCT
fb494744f63	15	17	2	2	X
fb494744f63	15	18	)	)	PUNCT
fb494744f63	15	19	to	to	PART
fb494744f63	15	20	investigate	investigate	VERB
fb494744f63	15	21	the	the	DET
fb494744f63	15	22	role	role	NOUN
fb494744f63	15	23	of	of	ADP
fb494744f63	15	24	bmp-4	bmp-4	PRON
fb494744f63	15	25	and	and	CCONJ
fb494744f63	15	26	tgf-β1	tgf-β1	PROPN
fb494744f63	15	27	in	in	ADP
fb494744f63	15	28	fss	fss	ADV
fb494744f63	15	29	-	-	PUNCT
fb494744f63	15	30	induced	induce	VERB
fb494744f63	15	31	valvular	valvular	ADJ
fb494744f63	15	32	endothelial	endothelial	ADJ
fb494744f63	15	33	activation	activation	NOUN
fb494744f63	15	34	and	and	CCONJ
fb494744f63	15	35	ecm	ecm	NOUN
fb494744f63	15	36	remodeling	remodeling	NOUN
fb494744f63	15	37	;	;	PUNCT
fb494744f63	15	38	and	and	CCONJ
fb494744f63	15	39	3	3	X
fb494744f63	15	40	)	)	PUNCT
fb494744f63	15	41	to	to	PART
fb494744f63	15	42	elucidate	elucidate	VERB
fb494744f63	15	43	the	the	DET
fb494744f63	15	44	mechanisms	mechanism	NOUN
fb494744f63	15	45	of	of	ADP
fb494744f63	15	46	cavd	cavd	NOUN
fb494744f63	15	47	secondary	secondary	ADJ
fb494744f63	15	48	to	to	AUX
fb494744f63	15	49	bav	bav	VERB
fb494744f63	15	50	hemodynamic	hemodynamic	ADJ
fb494744f63	15	51	abnormalities	abnormality	NOUN
fb494744f63	15	52	.	.	PUNCT
fb494744f63	16	1	the	the	DET
fb494744f63	16	2	approach	approach	NOUN
fb494744f63	16	3	integrated	integrate	VERB
fb494744f63	16	4	the	the	DET
fb494744f63	16	5	implementations	implementation	NOUN
fb494744f63	16	6	of	of	ADP
fb494744f63	16	7	a	a	DET
fb494744f63	16	8	novel	novel	ADJ
fb494744f63	16	9	ex	ex	NOUN
fb494744f63	16	10	vivo	vivo	ADJ
fb494744f63	16	11	device	device	NOUN
fb494744f63	16	12	to	to	PART
fb494744f63	16	13	condition	condition	VERB
fb494744f63	16	14	porcine	porcine	NOUN
fb494744f63	16	15	av	av	NOUN
fb494744f63	16	16	leaflets	leaflet	NOUN
fb494744f63	16	17	under	under	ADP
fb494744f63	16	18	physiological	physiological	ADJ
fb494744f63	16	19	and	and	CCONJ
fb494744f63	16	20	pathologically	pathologically	ADV
fb494744f63	16	21	fss	fss	ADJ
fb494744f63	16	22	environments	environment	NOUN
fb494744f63	16	23	,	,	PUNCT
fb494744f63	16	24	standard	standard	ADJ
fb494744f63	16	25	biological	biological	ADJ
fb494744f63	16	26	techniques	technique	NOUN
fb494744f63	16	27	to	to	PART
fb494744f63	16	28	assess	assess	VERB
fb494744f63	16	29	valvular	valvular	ADJ
fb494744f63	16	30	biological	biological	ADJ
fb494744f63	16	31	response	response	NOUN
fb494744f63	16	32	and	and	CCONJ
fb494744f63	16	33	pharmacological	pharmacological	ADJ
fb494744f63	16	34	inhibition	inhibition	NOUN
fb494744f63	16	35	/	/	SYM
fb494744f63	16	36	promotion	promotion	NOUN
fb494744f63	16	37	to	to	PART
fb494744f63	16	38	elucidate	elucidate	VERB
fb494744f63	16	39	the	the	DET
fb494744f63	16	40	mechanisms	mechanism	NOUN
fb494744f63	16	41	of	of	ADP
fb494744f63	16	42	fss	fss	ADJ
fb494744f63	16	43	signal	signal	NOUN
fb494744f63	16	44	transduction	transduction	NOUN
fb494744f63	16	45	.	.	PUNCT
fb494744f63	17	1	as	as	ADP
fb494744f63	17	2	a	a	DET
fb494744f63	17	3	first	first	ADJ
fb494744f63	17	4	step	step	NOUN
fb494744f63	17	5	,	,	PUNCT
fb494744f63	17	6	a	a	DET
fb494744f63	17	7	fss	fss	ADJ
fb494744f63	17	8	bioreactor	bioreactor	NOUN
fb494744f63	17	9	was	be	AUX
fb494744f63	17	10	designed	design	VERB
fb494744f63	17	11	to	to	PART
fb494744f63	17	12	replicate	replicate	VERB
fb494744f63	17	13	the	the	DET
fb494744f63	17	14	native	native	ADJ
fb494744f63	17	15	side	side	NOUN
fb494744f63	17	16	-	-	PUNCT
fb494744f63	17	17	specific	specific	ADJ
fb494744f63	17	18	valvular	valvular	ADJ
fb494744f63	17	19	fss	fss	ADJ
fb494744f63	17	20	environment	environment	NOUN
fb494744f63	17	21	in	in	ADP
fb494744f63	17	22	the	the	DET
fb494744f63	17	23	laboratory	laboratory	NOUN
fb494744f63	17	24	setting	setting	NOUN
fb494744f63	17	25	.	.	PUNCT
fb494744f63	18	1	the	the	DET
fb494744f63	18	2	bioreactor	bioreactor	NOUN
fb494744f63	18	3	was	be	AUX
fb494744f63	18	4	validated	validate	VERB
fb494744f63	18	5	mechanically	mechanically	ADV
fb494744f63	18	6	using	use	VERB
fb494744f63	18	7	fluid	fluid	ADJ
fb494744f63	18	8	structure	structure	NOUN
fb494744f63	18	9	interaction	interaction	NOUN
fb494744f63	18	10	modeling	modeling	NOUN
fb494744f63	18	11	and	and	CCONJ
fb494744f63	18	12	biologically	biologically	ADV
fb494744f63	18	13	in	in	ADP
fb494744f63	18	14	terms	term	NOUN
fb494744f63	18	15	of	of	ADP
fb494744f63	18	16	sterility	sterility	NOUN
fb494744f63	18	17	and	and	CCONJ
fb494744f63	18	18	tissue	tissue	NOUN
fb494744f63	18	19	viability	viability	NOUN
fb494744f63	18	20	.	.	PUNCT
fb494744f63	19	1	the	the	DET
fb494744f63	19	2	programming	programming	NOUN
fb494744f63	19	3	of	of	ADP
fb494744f63	19	4	the	the	DET
fb494744f63	19	5	bioreactor	bioreactor	NOUN
fb494744f63	19	6	with	with	ADP
fb494744f63	19	7	both	both	CCONJ
fb494744f63	19	8	physiological	physiological	ADJ
fb494744f63	19	9	and	and	CCONJ
fb494744f63	19	10	pathological	pathological	ADJ
fb494744f63	19	11	waveforms	waveform	NOUN
fb494744f63	19	12	permitted	permit	VERB
fb494744f63	19	13	to	to	PART
fb494744f63	19	14	investigate	investigate	VERB
fb494744f63	19	15	the	the	DET
fb494744f63	19	16	role	role	NOUN
fb494744f63	19	17	of	of	ADP
fb494744f63	19	18	fss	fss	ADJ
fb494744f63	19	19	in	in	ADP
fb494744f63	19	20	valvular	valvular	ADJ
fb494744f63	19	21	pathogenesis	pathogenesis	NOUN
fb494744f63	19	22	.	.	PUNCT
fb494744f63	20	1	specific	specific	ADJ
fb494744f63	20	2	aim	aim	NOUN
fb494744f63	20	3	1	1	NUM
fb494744f63	20	4	sought	seek	VERB
fb494744f63	20	5	to	to	PART
fb494744f63	20	6	elucidate	elucidate	VERB
fb494744f63	20	7	the	the	DET
fb494744f63	20	8	modes	mode	NOUN
fb494744f63	20	9	of	of	ADP
fb494744f63	20	10	fss	fss	ADJ
fb494744f63	20	11	mechanotransduction	mechanotransduction	NOUN
fb494744f63	20	12	in	in	ADP
fb494744f63	20	13	av	av	NOUN
fb494744f63	20	14	tissue	tissue	NOUN
fb494744f63	20	15	and	and	CCONJ
fb494744f63	20	16	the	the	DET
fb494744f63	20	17	respective	respective	ADJ
fb494744f63	20	18	role	role	NOUN
fb494744f63	20	19	of	of	ADP
fb494744f63	20	20	fss	fss	ADJ
fb494744f63	20	21	magnitude	magnitude	NOUN
fb494744f63	20	22	and/or	and/or	CCONJ
fb494744f63	20	23	frequency	frequency	NOUN
fb494744f63	20	24	abnormalities	abnormality	NOUN
fb494744f63	20	25	in	in	ADP
fb494744f63	20	26	cavd	cavd	NOUN
fb494744f63	20	27	.	.	PUNCT
fb494744f63	21	1	porcine	porcine	NOUN
fb494744f63	21	2	leaflets	leaflet	NOUN
fb494744f63	21	3	were	be	AUX
fb494744f63	21	4	subjected	subject	VERB
fb494744f63	21	5	to	to	ADP
fb494744f63	21	6	9	9	NUM
fb494744f63	21	7	fss	fss	NOUN
fb494744f63	21	8	environments	environment	NOUN
fb494744f63	21	9	defined	define	VERB
fb494744f63	21	10	by	by	ADP
fb494744f63	21	11	isolated	isolated	ADJ
fb494744f63	21	12	/	/	SYM
fb494744f63	21	13	combined	combine	VERB
fb494744f63	21	14	abnormalities	abnormality	NOUN
fb494744f63	21	15	in	in	ADP
fb494744f63	21	16	fss	fss	ADJ
fb494744f63	21	17	magnitude	magnitude	NOUN
fb494744f63	21	18	and	and	CCONJ
fb494744f63	21	19	frequency	frequency	NOUN
fb494744f63	21	20	.	.	PUNCT
fb494744f63	22	1	while	while	SCONJ
fb494744f63	22	2	cytokine	cytokine	NOUN
fb494744f63	22	3	expression	expression	NOUN
fb494744f63	22	4	was	be	AUX
fb494744f63	22	5	stimulated	stimulate	VERB
fb494744f63	22	6	under	under	ADP
fb494744f63	22	7	elevated	elevated	ADJ
fb494744f63	22	8	fss	fss	ADJ
fb494744f63	22	9	magnitude	magnitude	NOUN
fb494744f63	22	10	at	at	ADP
fb494744f63	22	11	normal	normal	ADJ
fb494744f63	22	12	frequency	frequency	NOUN
fb494744f63	22	13	,	,	PUNCT
fb494744f63	22	14	ecm	ecm	NOUN
fb494744f63	22	15	degradation	degradation	NOUN
fb494744f63	22	16	was	be	AUX
fb494744f63	22	17	stimulated	stimulate	VERB
fb494744f63	22	18	under	under	ADP
fb494744f63	22	19	both	both	DET
fb494744f63	22	20	elevated	elevated	ADJ
fb494744f63	22	21	fss	fss	ADJ
fb494744f63	22	22	magnitude	magnitude	NOUN
fb494744f63	22	23	at	at	ADP
fb494744f63	22	24	normal	normal	ADJ
fb494744f63	22	25	frequency	frequency	NOUN
fb494744f63	22	26	and	and	CCONJ
fb494744f63	22	27	physiologic	physiologic	ADJ
fb494744f63	22	28	fss	fss	ADJ
fb494744f63	22	29	magnitude	magnitude	NOUN
fb494744f63	22	30	at	at	ADP
fb494744f63	22	31	abnormal	abnormal	ADJ
fb494744f63	22	32	frequency	frequency	NOUN
fb494744f63	22	33	.	.	PUNCT
fb494744f63	23	1	in	in	ADP
fb494744f63	23	2	contrast	contrast	NOUN
fb494744f63	23	3	,	,	PUNCT
fb494744f63	23	4	combined	combine	VERB
fb494744f63	23	5	fss	fss	ADJ
fb494744f63	23	6	magnitude	magnitude	NOUN
fb494744f63	23	7	and	and	CCONJ
fb494744f63	23	8	frequency	frequency	NOUN
fb494744f63	23	9	abnormalities	abnormality	NOUN
fb494744f63	23	10	essentially	essentially	ADV
fb494744f63	23	11	maintained	maintain	VERB
fb494744f63	23	12	valvular	valvular	ADJ
fb494744f63	23	13	homeostasis	homeostasis	NOUN
fb494744f63	23	14	.	.	PUNCT
fb494744f63	24	1	the	the	DET
fb494744f63	24	2	results	result	NOUN
fb494744f63	24	3	revealed	reveal	VERB
fb494744f63	24	4	the	the	DET
fb494744f63	24	5	particular	particular	ADJ
fb494744f63	24	6	sensitivity	sensitivity	NOUN
fb494744f63	24	7	of	of	ADP
fb494744f63	24	8	valvular	valvular	ADJ
fb494744f63	24	9	tissue	tissue	NOUN
fb494744f63	24	10	to	to	ADP
fb494744f63	24	11	fss	fss	ADJ
fb494744f63	24	12	magnitude	magnitude	NOUN
fb494744f63	24	13	as	as	SCONJ
fb494744f63	24	14	opposed	oppose	VERB
fb494744f63	24	15	to	to	ADP
fb494744f63	24	16	fss	fss	ADJ
fb494744f63	24	17	frequency	frequency	NOUN
fb494744f63	24	18	.	.	PUNCT
fb494744f63	25	1	in	in	ADP
fb494744f63	25	2	specific	specific	ADJ
fb494744f63	25	3	aim	aim	NOUN
fb494744f63	25	4	2	2	NUM
fb494744f63	25	5	,	,	PUNCT
fb494744f63	25	6	the	the	DET
fb494744f63	25	7	goal	goal	NOUN
fb494744f63	25	8	was	be	AUX
fb494744f63	25	9	to	to	PART
fb494744f63	25	10	determine	determine	VERB
fb494744f63	25	11	the	the	DET
fb494744f63	25	12	role	role	NOUN
fb494744f63	25	13	of	of	ADP
fb494744f63	25	14	bmp-4	bmp-4	PRON
fb494744f63	25	15	and	and	CCONJ
fb494744f63	25	16	tgf-β1	tgf-β1	PROPN
fb494744f63	25	17	in	in	ADP
fb494744f63	25	18	fss	fss	ADV
fb494744f63	25	19	-	-	PUNCT
fb494744f63	25	20	induced	induce	VERB
fb494744f63	25	21	valvular	valvular	ADJ
fb494744f63	25	22	endothelial	endothelial	ADJ
fb494744f63	25	23	activation	activation	NOUN
fb494744f63	25	24	and	and	CCONJ
fb494744f63	25	25	ecm	ecm	NOUN
fb494744f63	25	26	remodeling	remodeling	PROPN
fb494744f63	25	27	.	.	PUNCT
fb494744f63	26	1	the	the	DET
fb494744f63	26	2	methodology	methodology	NOUN
fb494744f63	26	3	involved	involve	VERB
fb494744f63	26	4	the	the	DET
fb494744f63	26	5	ex	ex	ADJ
fb494744f63	26	6	vivo	vivo	ADJ
fb494744f63	26	7	exposure	exposure	NOUN
fb494744f63	26	8	of	of	ADP
fb494744f63	26	9	porcine	porcine	NOUN
fb494744f63	26	10	aortic	aortic	NOUN
fb494744f63	26	11	valve	valve	NOUN
fb494744f63	26	12	leaflets	leaflet	NOUN
fb494744f63	26	13	to	to	ADP
fb494744f63	26	14	side	side	NOUN
fb494744f63	26	15	-	-	PUNCT
fb494744f63	26	16	specific	specific	ADJ
fb494744f63	26	17	physiological	physiological	ADJ
fb494744f63	26	18	/	/	SYM
fb494744f63	26	19	pathological	pathological	ADJ
fb494744f63	26	20	fss	fss	NOUN
fb494744f63	26	21	and	and	CCONJ
fb494744f63	26	22	the	the	DET
fb494744f63	26	23	use	use	NOUN
fb494744f63	26	24	of	of	ADP
fb494744f63	26	25	pharmacological	pharmacological	ADJ
fb494744f63	26	26	promoters	promoter	NOUN
fb494744f63	26	27	/	/	SYM
fb494744f63	26	28	inhibitors	inhibitor	NOUN
fb494744f63	26	29	of	of	ADP
fb494744f63	26	30	bmp-4	bmp-4	PRON
fb494744f63	26	31	or	or	CCONJ
fb494744f63	26	32	tgf-β1	tgf-β1	PROPN
fb494744f63	26	33	.	.	PUNCT
fb494744f63	27	1	the	the	DET
fb494744f63	27	2	results	result	NOUN
fb494744f63	27	3	revealed	reveal	VERB
fb494744f63	27	4	the	the	DET
fb494744f63	27	5	important	important	ADJ
fb494744f63	27	6	role	role	NOUN
fb494744f63	27	7	played	play	VERB
fb494744f63	27	8	by	by	ADP
fb494744f63	27	9	tgf-β1	tgf-β1	PROPN
fb494744f63	27	10	in	in	ADP
fb494744f63	27	11	valvular	valvular	ADJ
fb494744f63	27	12	remodeling	remodeling	NOUN
fb494744f63	27	13	through	through	ADP
fb494744f63	27	14	mmp-9	mmp-9	PRON
fb494744f63	27	15	regulation	regulation	NOUN
fb494744f63	27	16	.	.	PUNCT
fb494744f63	28	1	specific	specific	ADJ
fb494744f63	28	2	aim	aim	NOUN
fb494744f63	28	3	3	3	NUM
fb494744f63	28	4	investigated	investigate	VERB
fb494744f63	28	5	how	how	SCONJ
fb494744f63	28	6	bav	bav	NOUN
fb494744f63	28	7	hemodynamic	hemodynamic	ADJ
fb494744f63	28	8	fss	fss	ADJ
fb494744f63	28	9	abnormalities	abnormality	NOUN
fb494744f63	28	10	contribute	contribute	VERB
fb494744f63	28	11	to	to	ADP
fb494744f63	28	12	early	early	ADJ
fb494744f63	28	13	progression	progression	NOUN
fb494744f63	28	14	of	of	ADP
fb494744f63	28	15	cavd	cavd	NOUN
fb494744f63	28	16	.	.	PUNCT
fb494744f63	29	1	porcine	porcine	NOUN
fb494744f63	29	2	leaflets	leaflet	NOUN
fb494744f63	29	3	were	be	AUX
fb494744f63	29	4	exposed	expose	VERB
fb494744f63	29	5	ex	ex	NOUN
fb494744f63	29	6	vivo	vivo	NOUN
fb494744f63	29	7	to	to	ADP
fb494744f63	29	8	the	the	DET
fb494744f63	29	9	native	native	ADJ
fb494744f63	29	10	tav	tav	PROPN
fb494744f63	29	11	and	and	CCONJ
fb494744f63	29	12	type-1	type-1	PROPN
fb494744f63	29	13	bav	bav	NOUN
fb494744f63	29	14	fss	fss	ADJ
fb494744f63	30	1	and	and	CCONJ
fb494744f63	30	2	their	their	PRON
fb494744f63	30	3	acute	acute	ADJ
fb494744f63	30	4	pathological	pathological	ADJ
fb494744f63	30	5	response	response	NOUN
fb494744f63	30	6	was	be	AUX
fb494744f63	30	7	examined	examine	VERB
fb494744f63	30	8	,	,	PUNCT
fb494744f63	30	9	including	include	VERB
fb494744f63	30	10	endothelial	endothelial	ADJ
fb494744f63	30	11	activation	activation	NOUN
fb494744f63	30	12	,	,	PUNCT
fb494744f63	30	13	pro	pro	ADJ
fb494744f63	30	14	-	-	ADJ
fb494744f63	30	15	inflammatory	inflammatory	ADJ
fb494744f63	30	16	paracrine	paracrine	NOUN
fb494744f63	30	17	signaling	signaling	NOUN
fb494744f63	30	18	,	,	PUNCT
fb494744f63	30	19	vic	vic	ADJ
fb494744f63	30	20	activation	activation	NOUN
fb494744f63	30	21	and	and	CCONJ
fb494744f63	30	22	osteogenesis	osteogenesis	NOUN
fb494744f63	30	23	.	.	PUNCT
fb494744f63	31	1	the	the	DET
fb494744f63	31	2	results	result	NOUN
fb494744f63	31	3	revealed	reveal	VERB
fb494744f63	31	4	the	the	DET
fb494744f63	31	5	pathogenic	pathogenic	ADJ
fb494744f63	31	6	potential	potential	NOUN
fb494744f63	31	7	of	of	ADP
fb494744f63	31	8	the	the	DET
fb494744f63	31	9	native	native	ADJ
fb494744f63	31	10	bav	bav	PROPN
fb494744f63	31	11	hemodynamic	hemodynamic	ADJ
fb494744f63	31	12	environment	environment	NOUN
fb494744f63	31	13	and	and	CCONJ
fb494744f63	31	14	the	the	DET
fb494744f63	31	15	particular	particular	ADJ
fb494744f63	31	16	vulnerability	vulnerability	NOUN
fb494744f63	31	17	of	of	ADP
fb494744f63	31	18	the	the	DET
fb494744f63	31	19	fused	fuse	VERB
fb494744f63	31	20	bav	bav	NOUN
fb494744f63	31	21	leaflet	leaflet	NOUN
fb494744f63	31	22	to	to	ADP
fb494744f63	31	23	calcification	calcification	NOUN
fb494744f63	31	24	.	.	PUNCT
fb494744f63	32	1	in	in	ADP
fb494744f63	32	2	conclusion	conclusion	NOUN
fb494744f63	32	3	,	,	PUNCT
fb494744f63	32	4	the	the	DET
fb494744f63	32	5	contribution	contribution	NOUN
fb494744f63	32	6	of	of	ADP
fb494744f63	32	7	fss	fss	ADJ
fb494744f63	32	8	to	to	ADP
fb494744f63	32	9	the	the	DET
fb494744f63	32	10	onset	onset	NOUN
fb494744f63	32	11	and	and	CCONJ
fb494744f63	32	12	early	early	ADJ
fb494744f63	32	13	progression	progression	NOUN
fb494744f63	32	14	of	of	ADP
fb494744f63	32	15	cavd	cavd	NOUN
fb494744f63	32	16	has	have	AUX
fb494744f63	32	17	been	be	AUX
fb494744f63	32	18	demonstrated	demonstrate	VERB
fb494744f63	32	19	in	in	ADP
fb494744f63	32	20	this	this	DET
fb494744f63	32	21	thesis	thesis	NOUN
fb494744f63	32	22	work	work	NOUN
fb494744f63	32	23	.	.	PUNCT
fb494744f63	33	1	the	the	DET
fb494744f63	33	2	relationship	relationship	NOUN
fb494744f63	33	3	between	between	ADP
fb494744f63	33	4	fss	fss	ADJ
fb494744f63	33	5	magnitude	magnitude	NOUN
fb494744f63	33	6	/	/	SYM
fb494744f63	33	7	frequency	frequency	NOUN
fb494744f63	33	8	and	and	CCONJ
fb494744f63	33	9	valvular	valvular	ADJ
fb494744f63	33	10	responses	response	NOUN
fb494744f63	33	11	can	can	AUX
fb494744f63	33	12	be	be	AUX
fb494744f63	33	13	used	use	VERB
fb494744f63	33	14	as	as	ADP
fb494744f63	33	15	input	input	NOUN
fb494744f63	33	16	for	for	ADP
fb494744f63	33	17	prediction	prediction	NOUN
fb494744f63	33	18	of	of	ADP
fb494744f63	33	19	cavd	cavd	NOUN
fb494744f63	33	20	progression	progression	NOUN
fb494744f63	33	21	.	.	PUNCT
fb494744f63	34	1	in	in	ADP
fb494744f63	34	2	addition	addition	NOUN
fb494744f63	34	3	,	,	PUNCT
fb494744f63	34	4	the	the	DET
fb494744f63	34	5	findings	finding	NOUN
fb494744f63	34	6	from	from	ADP
fb494744f63	34	7	this	this	DET
fb494744f63	34	8	dissertation	dissertation	NOUN
fb494744f63	34	9	can	can	AUX
fb494744f63	34	10	be	be	AUX
fb494744f63	34	11	used	use	VERB
fb494744f63	34	12	to	to	PART
fb494744f63	34	13	further	far	ADV
fb494744f63	34	14	investigate	investigate	VERB
fb494744f63	34	15	the	the	DET
fb494744f63	34	16	molecular	molecular	ADJ
fb494744f63	34	17	signaling	signal	VERB
fb494744f63	34	18	mechanisms	mechanism	NOUN
fb494744f63	34	19	in	in	ADP
fb494744f63	34	20	order	order	NOUN
fb494744f63	34	21	to	to	PART
fb494744f63	34	22	develop	develop	VERB
fb494744f63	34	23	pharmacological	pharmacological	ADJ
fb494744f63	34	24	treatments	treatment	NOUN
fb494744f63	34	25	of	of	ADP
fb494744f63	34	26	cavd	cavd	NOUN
fb494744f63	34	27	.	.	PUNCT