id sid tid token lemma pos f1881j94m5h 1 1 chikungunya chikungunya PROPN f1881j94m5h 1 2 ( ( PUNCT f1881j94m5h 1 3 chikv chikv PROPN f1881j94m5h 1 4 ) ) PUNCT f1881j94m5h 1 5 virus virus NOUN f1881j94m5h 1 6 is be AUX f1881j94m5h 1 7 an an DET f1881j94m5h 1 8 alphavirus alphavirus PROPN f1881j94m5h 1 9 , , PUNCT f1881j94m5h 1 10 transmitted transmit VERB f1881j94m5h 1 11 to to ADP f1881j94m5h 1 12 humans human NOUN f1881j94m5h 1 13 by by ADP f1881j94m5h 1 14 the the DET f1881j94m5h 1 15 bite bite NOUN f1881j94m5h 1 16 of of ADP f1881j94m5h 1 17 the the DET f1881j94m5h 1 18 infected infected ADJ f1881j94m5h 1 19 aedes aedes PROPN f1881j94m5h 1 20 mosquitoes mosquitoes PROPN f1881j94m5h 1 21 . . PUNCT f1881j94m5h 2 1 transgenic transgenic NOUN f1881j94m5h 2 2 mosquitoes mosquito NOUN f1881j94m5h 2 3 with with ADP f1881j94m5h 2 4 resistance resistance NOUN f1881j94m5h 2 5 to to ADP f1881j94m5h 2 6 chikv chikv ADJ f1881j94m5h 2 7 replication replication NOUN f1881j94m5h 2 8 could could AUX f1881j94m5h 2 9 control control VERB f1881j94m5h 2 10 the the DET f1881j94m5h 2 11 spread spread NOUN f1881j94m5h 2 12 of of ADP f1881j94m5h 2 13 the the DET f1881j94m5h 2 14 virus virus NOUN f1881j94m5h 2 15 among among ADP f1881j94m5h 2 16 humans human NOUN f1881j94m5h 2 17 . . PUNCT f1881j94m5h 3 1 we we PRON f1881j94m5h 3 2 designed design VERB f1881j94m5h 3 3 8 8 NUM f1881j94m5h 3 4 hammerhead hammerhead NOUN f1881j94m5h 3 5 ribozymes ribozyme NOUN f1881j94m5h 3 6 ( ( PUNCT f1881j94m5h 3 7 hrz#1 hrz#1 PROPN f1881j94m5h 3 8 , , PUNCT f1881j94m5h 3 9 2 2 NUM f1881j94m5h 3 10 , , PUNCT f1881j94m5h 3 11 3 3 NUM f1881j94m5h 3 12 , , PUNCT f1881j94m5h 3 13 4 4 NUM f1881j94m5h 3 14 , , PUNCT f1881j94m5h 3 15 5 5 NUM f1881j94m5h 3 16 , , PUNCT f1881j94m5h 3 17 6 6 NUM f1881j94m5h 3 18 , , PUNCT f1881j94m5h 3 19 7 7 NUM f1881j94m5h 3 20 , , PUNCT f1881j94m5h 3 21 8) 8) NUM f1881j94m5h 3 22 against against ADP f1881j94m5h 3 23 conserved conserve VERB f1881j94m5h 3 24 regions region NOUN f1881j94m5h 3 25 within within ADP f1881j94m5h 3 26 the the DET f1881j94m5h 3 27 nonstructural nonstructural ADJ f1881j94m5h 3 28 genes gene NOUN f1881j94m5h 3 29 ( ( PUNCT f1881j94m5h 3 30 nsp1 nsp1 PROPN f1881j94m5h 3 31 , , PUNCT f1881j94m5h 3 32 nsp2 nsp2 PROPN f1881j94m5h 3 33 , , PUNCT f1881j94m5h 3 34 nsp3 nsp3 PROPN f1881j94m5h 3 35 and and CCONJ f1881j94m5h 3 36 nsp4 nsp4 PROPN f1881j94m5h 3 37 ) ) PUNCT f1881j94m5h 3 38 of of ADP f1881j94m5h 3 39 the the DET f1881j94m5h 3 40 chikv chikv ADJ f1881j94m5h 3 41 viral viral ADJ f1881j94m5h 3 42 genome genome NOUN f1881j94m5h 3 43 . . PUNCT f1881j94m5h 4 1 in in ADP f1881j94m5h 4 2 vitro vitro X f1881j94m5h 4 3 cleavage cleavage NOUN f1881j94m5h 4 4 assays assay NOUN f1881j94m5h 4 5 demonstrated demonstrate VERB f1881j94m5h 4 6 the the DET f1881j94m5h 4 7 catalytic catalytic ADJ f1881j94m5h 4 8 activity activity NOUN f1881j94m5h 4 9 of of ADP f1881j94m5h 4 10 these these DET f1881j94m5h 4 11 hrzs hrzs NOUN f1881j94m5h 4 12 against against ADP f1881j94m5h 4 13 artificial artificial ADJ f1881j94m5h 4 14 chikv chikv NOUN f1881j94m5h 4 15 target target NOUN f1881j94m5h 4 16 rnas rna NOUN f1881j94m5h 4 17 . . PUNCT f1881j94m5h 5 1 these these DET f1881j94m5h 5 2 hrzs hrzs NOUN f1881j94m5h 5 3 were be AUX f1881j94m5h 5 4 cloned clone VERB f1881j94m5h 5 5 into into ADP f1881j94m5h 5 6 a a DET f1881j94m5h 5 7 pantrophic pantrophic ADJ f1881j94m5h 5 8 retrovirus retrovirus NOUN f1881j94m5h 5 9 vector vector NOUN f1881j94m5h 5 10 with with ADP f1881j94m5h 5 11 aedes aedes PROPN f1881j94m5h 5 12 trnaval trnaval PROPN f1881j94m5h 5 13 pol pol PROPN f1881j94m5h 5 14 iii iii NUM f1881j94m5h 5 15 driving driving NOUN f1881j94m5h 5 16 expression expression NOUN f1881j94m5h 5 17 of of ADP f1881j94m5h 5 18 the the DET f1881j94m5h 5 19 hrzs hrzs NOUN f1881j94m5h 5 20 , , PUNCT f1881j94m5h 5 21 and and CCONJ f1881j94m5h 5 22 a a DET f1881j94m5h 5 23 poly poly ADJ f1881j94m5h 5 24 a a DET f1881j94m5h 5 25 ( ( PUNCT f1881j94m5h 5 26 60 60 NUM f1881j94m5h 5 27 ) ) PUNCT f1881j94m5h 5 28 tail tail NOUN f1881j94m5h 5 29 sequence sequence NOUN f1881j94m5h 5 30 to to PART f1881j94m5h 5 31 recruit recruit VERB f1881j94m5h 5 32 rna rna PROPN f1881j94m5h 5 33 helicase helicase NOUN f1881j94m5h 5 34 for for ADP f1881j94m5h 5 35 disruption disruption NOUN f1881j94m5h 5 36 of of ADP f1881j94m5h 5 37 secondary secondary ADJ f1881j94m5h 5 38 structure structure NOUN f1881j94m5h 5 39 in in ADP f1881j94m5h 5 40 the the DET f1881j94m5h 5 41 target target NOUN f1881j94m5h 5 42 viral viral ADJ f1881j94m5h 5 43 rna rna PROPN f1881j94m5h 5 44 . . PUNCT f1881j94m5h 6 1 the the DET f1881j94m5h 6 2 cloned cloned ADJ f1881j94m5h 6 3 plasmids plasmid NOUN f1881j94m5h 6 4 were be AUX f1881j94m5h 6 5 transfected transfecte VERB f1881j94m5h 6 6 into into ADP f1881j94m5h 6 7 vero vero PROPN f1881j94m5h 6 8 cells cell NOUN f1881j94m5h 6 9 and and CCONJ f1881j94m5h 6 10 selected select VERB f1881j94m5h 6 11 for for ADP f1881j94m5h 6 12 hygromycin hygromycin PROPN f1881j94m5h 6 13 resistance resistance NOUN f1881j94m5h 6 14 for for ADP f1881j94m5h 6 15 6 6 NUM f1881j94m5h 6 16 - - SYM f1881j94m5h 6 17 8 8 NUM f1881j94m5h 6 18 weeks week NOUN f1881j94m5h 6 19 . . PUNCT f1881j94m5h 7 1 reverse reverse ADJ f1881j94m5h 7 2 transcriptase transcriptase NOUN f1881j94m5h 7 3 pcr pcr NOUN f1881j94m5h 7 4 confirmed confirm VERB f1881j94m5h 7 5 expression expression NOUN f1881j94m5h 7 6 of of ADP f1881j94m5h 7 7 all all DET f1881j94m5h 7 8 hrzs hrzs NOUN f1881j94m5h 7 9 in in ADP f1881j94m5h 7 10 the the DET f1881j94m5h 7 11 transformed transformed ADJ f1881j94m5h 7 12 cells cell NOUN f1881j94m5h 7 13 . . PUNCT f1881j94m5h 8 1 the the DET f1881j94m5h 8 2 transformed transformed ADJ f1881j94m5h 8 3 cell cell NOUN f1881j94m5h 8 4 lines line NOUN f1881j94m5h 8 5 were be AUX f1881j94m5h 8 6 challenged challenge VERB f1881j94m5h 8 7 with with ADP f1881j94m5h 8 8 the the DET f1881j94m5h 8 9 chikv chikv ADJ f1881j94m5h 8 10 181/25 181/25 NUM f1881j94m5h 8 11 strain strain NOUN f1881j94m5h 8 12 at at ADP f1881j94m5h 8 13 a a DET f1881j94m5h 8 14 moi moi NOUN f1881j94m5h 8 15 of of ADP f1881j94m5h 8 16 0.0001 0.0001 NUM f1881j94m5h 8 17 and and CCONJ f1881j94m5h 8 18 the the DET f1881j94m5h 8 19 viral viral ADJ f1881j94m5h 8 20 titer titer NOUN f1881j94m5h 8 21 of of ADP f1881j94m5h 8 22 the the DET f1881j94m5h 8 23 supernatants supernatant NOUN f1881j94m5h 8 24 was be AUX f1881j94m5h 8 25 determined determine VERB f1881j94m5h 8 26 at at ADP f1881j94m5h 8 27 2 2 NUM f1881j94m5h 8 28 days day NOUN f1881j94m5h 8 29 post post NOUN f1881j94m5h 8 30 infection infection NOUN f1881j94m5h 8 31 by by ADP f1881j94m5h 8 32 using use VERB f1881j94m5h 8 33 a a DET f1881j94m5h 8 34 tcid50 tcid50 SPACE f1881j94m5h 8 35 - - NOUN f1881j94m5h 8 36 cpe cpe PROPN f1881j94m5h 8 37 assay assay NOUN f1881j94m5h 8 38 . . PUNCT f1881j94m5h 9 1 hrz#1 hrz#1 PROPN f1881j94m5h 9 2 and and CCONJ f1881j94m5h 9 3 hrz#8 hrz#8 NOUN f1881j94m5h 9 4 targeting target VERB f1881j94m5h 9 5 the the DET f1881j94m5h 9 6 nsp1 nsp1 NOUN f1881j94m5h 9 7 and and CCONJ f1881j94m5h 9 8 nsp4 nsp4 PROPN f1881j94m5h 9 9 genes gene NOUN f1881j94m5h 9 10 , , PUNCT f1881j94m5h 9 11 respectively respectively ADV f1881j94m5h 9 12 , , PUNCT f1881j94m5h 9 13 yielded yield VERB f1881j94m5h 9 14 2 2 NUM f1881j94m5h 9 15 and and CCONJ f1881j94m5h 9 16 5 5 NUM f1881j94m5h 9 17 logs log NOUN f1881j94m5h 9 18 suppression suppression NOUN f1881j94m5h 9 19 of of ADP f1881j94m5h 9 20 chikv chikv ADJ f1881j94m5h 9 21 replication replication NOUN f1881j94m5h 9 22 as as SCONJ f1881j94m5h 9 23 compared compare VERB f1881j94m5h 9 24 to to ADP f1881j94m5h 9 25 wild wild ADJ f1881j94m5h 9 26 type type NOUN f1881j94m5h 9 27 infected infect VERB f1881j94m5h 9 28 vero vero PROPN f1881j94m5h 9 29 cells cell NOUN f1881j94m5h 9 30 . . PUNCT f1881j94m5h 10 1 homogenous homogenous ADJ f1881j94m5h 10 2 cell cell NOUN f1881j94m5h 10 3 populations population NOUN f1881j94m5h 10 4 were be AUX f1881j94m5h 10 5 obtained obtain VERB f1881j94m5h 10 6 by by ADP f1881j94m5h 10 7 single single ADJ f1881j94m5h 10 8 cell cell NOUN f1881j94m5h 10 9 sorting sorting NOUN f1881j94m5h 10 10 of of ADP f1881j94m5h 10 11 hrz hrz PROPN f1881j94m5h 10 12 transformed transform VERB f1881j94m5h 10 13 cells cell NOUN f1881j94m5h 10 14 using use VERB f1881j94m5h 10 15 facs fac NOUN f1881j94m5h 10 16 , , PUNCT f1881j94m5h 10 17 and and CCONJ f1881j94m5h 10 18 the the DET f1881j94m5h 10 19 clones clone NOUN f1881j94m5h 10 20 were be AUX f1881j94m5h 10 21 challenged challenge VERB f1881j94m5h 10 22 with with ADP f1881j94m5h 10 23 chikv chikv NOUN f1881j94m5h 10 24 at at ADP f1881j94m5h 10 25 a a DET f1881j94m5h 10 26 moi moi X f1881j94m5h 10 27 of of ADP f1881j94m5h 10 28 0.0001 0.0001 NUM f1881j94m5h 10 29 . . PUNCT f1881j94m5h 11 1 the the DET f1881j94m5h 11 2 viral viral ADJ f1881j94m5h 11 3 titers titer NOUN f1881j94m5h 11 4 of of ADP f1881j94m5h 11 5 supernatants supernatant NOUN f1881j94m5h 11 6 determined determine VERB f1881j94m5h 11 7 at at ADP f1881j94m5h 11 8 3 3 NUM f1881j94m5h 11 9 dpi dpi NOUN f1881j94m5h 11 10 using use VERB f1881j94m5h 11 11 tcid50 tcid50 SPACE f1881j94m5h 11 12 - - PUNCT f1881j94m5h 11 13 ifa ifa NOUN f1881j94m5h 11 14 demonstrated demonstrate VERB f1881j94m5h 11 15 complete complete NOUN f1881j94m5h 11 16 of of ADP f1881j94m5h 11 17 suppression suppression NOUN f1881j94m5h 11 18 of of ADP f1881j94m5h 11 19 chikv chikv ADJ f1881j94m5h 11 20 replication replication NOUN f1881j94m5h 11 21 with with ADP f1881j94m5h 11 22 some some PRON f1881j94m5h 11 23 of of ADP f1881j94m5h 11 24 the the DET f1881j94m5h 11 25 hrz hrz PROPN f1881j94m5h 11 26 - - PUNCT f1881j94m5h 11 27 transformed transform VERB f1881j94m5h 11 28 vero vero PROPN f1881j94m5h 11 29 cell cell NOUN f1881j94m5h 11 30 clones clone NOUN f1881j94m5h 11 31 expressing express VERB f1881j94m5h 11 32 hrz hrz NOUN f1881j94m5h 11 33 # # SYM f1881j94m5h 11 34 2 2 NUM f1881j94m5h 11 35 , , PUNCT f1881j94m5h 11 36 4 4 NUM f1881j94m5h 11 37 , , PUNCT f1881j94m5h 11 38 5 5 NUM f1881j94m5h 11 39 , , PUNCT f1881j94m5h 11 40 6 6 NUM f1881j94m5h 11 41 and and CCONJ f1881j94m5h 11 42 8 8 NUM f1881j94m5h 11 43 . . PUNCT f1881j94m5h 12 1 qrt qrt PROPN f1881j94m5h 12 2 - - PUNCT f1881j94m5h 12 3 pcr pcr NOUN f1881j94m5h 12 4 also also ADV f1881j94m5h 12 5 showed show VERB f1881j94m5h 12 6 significant significant ADJ f1881j94m5h 12 7 reduction reduction NOUN f1881j94m5h 12 8 of of ADP f1881j94m5h 12 9 chikv chikv PROPN f1881j94m5h 12 10 rna rna PROPN f1881j94m5h 12 11 copies copy NOUN f1881j94m5h 12 12 with with ADP f1881j94m5h 12 13 these these DET f1881j94m5h 12 14 hrz hrz NOUN f1881j94m5h 12 15 - - PUNCT f1881j94m5h 12 16 transformed transform VERB f1881j94m5h 12 17 vero vero PROPN f1881j94m5h 12 18 cell cell NOUN f1881j94m5h 12 19 clones clone NOUN f1881j94m5h 12 20 as as SCONJ f1881j94m5h 12 21 compared compare VERB f1881j94m5h 12 22 to to ADP f1881j94m5h 12 23 the the DET f1881j94m5h 12 24 control control NOUN f1881j94m5h 12 25 negatives negative NOUN f1881j94m5h 12 26 . . PUNCT f1881j94m5h 13 1 indirect indirect ADJ f1881j94m5h 13 2 assessment assessment NOUN f1881j94m5h 13 3 of of ADP f1881j94m5h 13 4 caspase-3 caspase-3 PROPN f1881j94m5h 13 5 activity activity NOUN f1881j94m5h 13 6 from from ADP f1881j94m5h 13 7 the the DET f1881j94m5h 13 8 infected infected ADJ f1881j94m5h 13 9 supernatants supernatant NOUN f1881j94m5h 13 10 collected collect VERB f1881j94m5h 13 11 from from ADP f1881j94m5h 13 12 those those DET f1881j94m5h 13 13 clones clone NOUN f1881j94m5h 13 14 revealed reveal VERB f1881j94m5h 13 15 very very ADV f1881j94m5h 13 16 low low ADJ f1881j94m5h 13 17 levels level NOUN f1881j94m5h 13 18 of of ADP f1881j94m5h 13 19 caspase caspase NOUN f1881j94m5h 13 20 3 3 NUM f1881j94m5h 13 21 activity activity NOUN f1881j94m5h 13 22 as as SCONJ f1881j94m5h 13 23 compared compare VERB f1881j94m5h 13 24 to to ADP f1881j94m5h 13 25 negative negative ADJ f1881j94m5h 13 26 control control NOUN f1881j94m5h 13 27 , , PUNCT f1881j94m5h 13 28 chikv chikv PROPN f1881j94m5h 13 29 infected infected PROPN f1881j94m5h 13 30 vero vero PROPN f1881j94m5h 13 31 cells cell NOUN f1881j94m5h 13 32 . . PUNCT f1881j94m5h 14 1 hrz hrz NOUN f1881j94m5h 14 2 # # PROPN f1881j94m5h 14 3 2 2 NUM f1881j94m5h 14 4 , , PUNCT f1881j94m5h 14 5 4 4 NUM f1881j94m5h 14 6 , , PUNCT f1881j94m5h 14 7 5 5 NUM f1881j94m5h 14 8 , , PUNCT f1881j94m5h 14 9 6 6 NUM f1881j94m5h 14 10 and and CCONJ f1881j94m5h 14 11 8 8 NUM f1881j94m5h 14 12 are be AUX f1881j94m5h 14 13 ideal ideal ADJ f1881j94m5h 14 14 candidates candidate NOUN f1881j94m5h 14 15 for for ADP f1881j94m5h 14 16 generating generate VERB f1881j94m5h 14 17 transgenic transgenic NOUN f1881j94m5h 14 18 refractoriness refractoriness NOUN f1881j94m5h 14 19 in in ADP f1881j94m5h 14 20 mosquitoes mosquito NOUN f1881j94m5h 14 21 , , PUNCT f1881j94m5h 14 22 and and CCONJ f1881j94m5h 14 23 will will AUX f1881j94m5h 14 24 be be AUX f1881j94m5h 14 25 cloned clone VERB f1881j94m5h 14 26 into into ADP f1881j94m5h 14 27 the the DET f1881j94m5h 14 28 pxlbacii pxlbacii PROPN f1881j94m5h 14 29 3xp3 3xp3 NUM f1881j94m5h 14 30 ecfp ecfp NOUN f1881j94m5h 14 31 piggybac piggybac NOUN f1881j94m5h 14 32 transposon transposon PROPN f1881j94m5h 14 33 vector vector NOUN f1881j94m5h 14 34 for for ADP f1881j94m5h 14 35 injection injection NOUN f1881j94m5h 14 36 of of ADP f1881j94m5h 14 37 mosquito mosquito PROPN f1881j94m5h 14 38 embryos embryo NOUN f1881j94m5h 14 39 . . PUNCT f1881j94m5h 15 1 based base VERB f1881j94m5h 15 2 on on ADP f1881j94m5h 15 3 these these DET f1881j94m5h 15 4 in in ADP f1881j94m5h 15 5 vitro vitro X f1881j94m5h 15 6 studies study NOUN f1881j94m5h 15 7 , , PUNCT f1881j94m5h 15 8 we we PRON f1881j94m5h 15 9 anticipate anticipate VERB f1881j94m5h 15 10 that that SCONJ f1881j94m5h 15 11 transgenic transgenic NOUN f1881j94m5h 15 12 mosquitoes mosquito NOUN f1881j94m5h 15 13 expressing express VERB f1881j94m5h 15 14 these these DET f1881j94m5h 15 15 hammerhead hammerhead NOUN f1881j94m5h 15 16 ribozymes ribozyme NOUN f1881j94m5h 15 17 will will AUX f1881j94m5h 15 18 be be AUX f1881j94m5h 15 19 refractory refractory ADJ f1881j94m5h 15 20 to to ADP f1881j94m5h 15 21 chikv chikv VERB f1881j94m5h 15 22 infection infection NOUN f1881j94m5h 15 23 and and CCONJ f1881j94m5h 15 24 transmission transmission NOUN f1881j94m5h 15 25 , , PUNCT f1881j94m5h 15 26 and and CCONJ f1881j94m5h 15 27 may may AUX f1881j94m5h 15 28 be be AUX f1881j94m5h 15 29 useful useful ADJ f1881j94m5h 15 30 in in ADP f1881j94m5h 15 31 effective effective ADJ f1881j94m5h 15 32 suppression suppression NOUN f1881j94m5h 15 33 of of ADP f1881j94m5h 15 34 chikv chikv NOUN f1881j94m5h 15 35 in in ADP f1881j94m5h 15 36 natural natural ADJ f1881j94m5h 15 37 populations population NOUN f1881j94m5h 15 38 . . PUNCT