id sid tid token lemma pos dz010p12h95 1 1 around around ADV dz010p12h95 1 2 70 70 NUM dz010p12h95 1 3 % % NOUN dz010p12h95 1 4 of of ADP dz010p12h95 1 5 breast breast NOUN dz010p12h95 1 6 cancer cancer NOUN dz010p12h95 1 7 tumors tumor NOUN dz010p12h95 1 8 are be AUX dz010p12h95 1 9 estrogen estrogen NOUN dz010p12h95 1 10 receptor receptor NOUN dz010p12h95 1 11 positive positive ADJ dz010p12h95 1 12 ( ( PUNCT dz010p12h95 1 13 er+ er+ NOUN dz010p12h95 1 14 ) ) PUNCT dz010p12h95 1 15 . . PUNCT dz010p12h95 2 1 although although SCONJ dz010p12h95 2 2 endocrine endocrine NOUN dz010p12h95 2 3 therapies therapy NOUN dz010p12h95 2 4 like like ADP dz010p12h95 2 5 tamoxifen tamoxifen NOUN dz010p12h95 2 6 and and CCONJ dz010p12h95 2 7 fulvestrant fulvestrant NOUN dz010p12h95 2 8 have have AUX dz010p12h95 2 9 been be AUX dz010p12h95 2 10 the the DET dz010p12h95 2 11 mainstay mainstay NOUN dz010p12h95 2 12 for for ADP dz010p12h95 2 13 er+ er+ NOUN dz010p12h95 2 14 breast breast NOUN dz010p12h95 2 15 cancer cancer NOUN dz010p12h95 2 16 patient patient NOUN dz010p12h95 2 17 treatment treatment NOUN dz010p12h95 2 18 , , PUNCT dz010p12h95 2 19 about about ADV dz010p12h95 2 20 33 33 NUM dz010p12h95 2 21 % % NOUN dz010p12h95 2 22 of of ADP dz010p12h95 2 23 these these DET dz010p12h95 2 24 patients patient NOUN dz010p12h95 2 25 have have VERB dz010p12h95 2 26 tumors tumor NOUN dz010p12h95 2 27 that that PRON dz010p12h95 2 28 eventually eventually ADV dz010p12h95 2 29 relapse relapse VERB dz010p12h95 2 30 and and CCONJ dz010p12h95 2 31 develop develop VERB dz010p12h95 2 32 as as ADP dz010p12h95 2 33 recurrent recurrent ADJ dz010p12h95 2 34 metastatic metastatic ADJ dz010p12h95 2 35 tumors tumor NOUN dz010p12h95 2 36 that that PRON dz010p12h95 2 37 are be AUX dz010p12h95 2 38 resistant resistant ADJ dz010p12h95 2 39 to to PART dz010p12h95 2 40 endocrine endocrine VERB dz010p12h95 2 41 therapy therapy NOUN dz010p12h95 2 42 . . PUNCT dz010p12h95 3 1 the the DET dz010p12h95 3 2 molecular molecular ADJ dz010p12h95 3 3 mechanisms mechanism NOUN dz010p12h95 3 4 of of ADP dz010p12h95 3 5 endocrine endocrine NOUN dz010p12h95 3 6 therapy therapy NOUN dz010p12h95 3 7 resistance resistance NOUN dz010p12h95 3 8 are be AUX dz010p12h95 3 9 poorly poorly ADV dz010p12h95 3 10 understood.our understood.our NUM dz010p12h95 3 11 lab lab NOUN dz010p12h95 3 12 identified identify VERB dz010p12h95 3 13 the the DET dz010p12h95 3 14 oncogene oncogene NOUN dz010p12h95 3 15 and and CCONJ dz010p12h95 3 16 transcription transcription NOUN dz010p12h95 3 17 factor factor NOUN dz010p12h95 3 18 znf217 znf217 NOUN dz010p12h95 3 19 ( ( PUNCT dz010p12h95 3 20 human)/zfp217 human)/zfp217 NOUN dz010p12h95 3 21 ( ( PUNCT dz010p12h95 3 22 mouse mouse NOUN dz010p12h95 3 23 ) ) PUNCT dz010p12h95 3 24 as as ADP dz010p12h95 3 25 an an DET dz010p12h95 3 26 er er INTJ dz010p12h95 3 27 modulating modulate VERB dz010p12h95 3 28 protein protein NOUN dz010p12h95 3 29 which which PRON dz010p12h95 3 30 drives drive VERB dz010p12h95 3 31 tamoxifen tamoxifen NOUN dz010p12h95 3 32 resistance resistance NOUN dz010p12h95 3 33 in in ADP dz010p12h95 3 34 vivo vivo PROPN dz010p12h95 3 35 . . PUNCT dz010p12h95 4 1 however however ADV dz010p12h95 4 2 , , PUNCT dz010p12h95 4 3 no no DET dz010p12h95 4 4 studies study NOUN dz010p12h95 4 5 have have AUX dz010p12h95 4 6 described describe VERB dz010p12h95 4 7 mechanistic mechanistic ADJ dz010p12h95 4 8 information information NOUN dz010p12h95 4 9 on on ADP dz010p12h95 4 10 how how SCONJ dz010p12h95 4 11 znf217 znf217 NOUN dz010p12h95 4 12 causes cause VERB dz010p12h95 4 13 tamoxifen tamoxifen NOUN dz010p12h95 4 14 resistance resistance NOUN dz010p12h95 4 15 . . PUNCT dz010p12h95 5 1 ligand ligand NOUN dz010p12h95 5 2 independent independent ADJ dz010p12h95 5 3 activation activation NOUN dz010p12h95 5 4 of of ADP dz010p12h95 5 5 er er INTJ dz010p12h95 5 6 by by ADP dz010p12h95 5 7 growth growth NOUN dz010p12h95 5 8 factor factor NOUN dz010p12h95 5 9 signaling signal VERB dz010p12h95 5 10 pathways pathway NOUN dz010p12h95 5 11 is be AUX dz010p12h95 5 12 a a DET dz010p12h95 5 13 main main ADJ dz010p12h95 5 14 mechanism mechanism NOUN dz010p12h95 5 15 of of ADP dz010p12h95 5 16 tamoxifen tamoxifen NOUN dz010p12h95 5 17 resistance resistance NOUN dz010p12h95 5 18 . . PUNCT dz010p12h95 6 1 significantly significantly ADV dz010p12h95 6 2 , , PUNCT dz010p12h95 6 3 znf217 znf217 PROPN dz010p12h95 6 4 directly directly ADV dz010p12h95 6 5 activates activate VERB dz010p12h95 6 6 the the DET dz010p12h95 6 7 erbb3 erbb3 PROPN dz010p12h95 6 8 / / SYM dz010p12h95 6 9 pi3k pi3k NUM dz010p12h95 6 10 / / SYM dz010p12h95 6 11 akt akt NOUN dz010p12h95 6 12 signaling signal VERB dz010p12h95 6 13 pathway pathway NOUN dz010p12h95 6 14 . . PUNCT dz010p12h95 7 1 in in ADP dz010p12h95 7 2 this this DET dz010p12h95 7 3 study study NOUN dz010p12h95 7 4 , , PUNCT dz010p12h95 7 5 i i PRON dz010p12h95 7 6 identified identify VERB dz010p12h95 7 7 a a DET dz010p12h95 7 8 novel novel NOUN dz010p12h95 7 9 and and CCONJ dz010p12h95 7 10 prognostic prognostic PROPN dz010p12h95 7 11 znf217and znf217and PROPN dz010p12h95 7 12 nrg1-(ligand nrg1-(ligand NOUN dz010p12h95 7 13 of of ADP dz010p12h95 7 14 erbb3 erbb3 PROPN dz010p12h95 7 15 ) ) PUNCT dz010p12h95 7 16 dependent dependent ADJ dz010p12h95 7 17 gene gene NOUN dz010p12h95 7 18 expression expression NOUN dz010p12h95 7 19 signature signature NOUN dz010p12h95 7 20 by by ADP dz010p12h95 7 21 rna rna PROPN dz010p12h95 7 22 - - PUNCT dz010p12h95 7 23 seq seq PROPN dz010p12h95 7 24 and and CCONJ dz010p12h95 7 25 non non ADJ dz010p12h95 7 26 - - ADJ dz010p12h95 7 27 canonical canonical ADJ dz010p12h95 7 28 er er INTJ dz010p12h95 7 29 binding bind VERB dz010p12h95 7 30 sites site NOUN dz010p12h95 7 31 in in ADP dz010p12h95 7 32 the the DET dz010p12h95 7 33 genome genome NOUN dz010p12h95 7 34 by by ADP dz010p12h95 7 35 chip chip NOUN dz010p12h95 7 36 - - PUNCT dz010p12h95 7 37 seq seq NOUN dz010p12h95 7 38 in in ADP dz010p12h95 7 39 mcf7 mcf7 NOUN dz010p12h95 7 40 cells cell NOUN dz010p12h95 7 41 . . PUNCT dz010p12h95 8 1 through through ADP dz010p12h95 8 2 cut&run cut&run ADJ dz010p12h95 8 3 sequencing sequencing NOUN dz010p12h95 8 4 , , PUNCT dz010p12h95 8 5 i i PRON dz010p12h95 8 6 also also ADV dz010p12h95 8 7 discovered discover VERB dz010p12h95 8 8 erand erand PROPN dz010p12h95 8 9 nrg1 nrg1 PROPN dz010p12h95 8 10 - - PUNCT dz010p12h95 8 11 dependent dependent ADJ dz010p12h95 8 12 znf217 znf217 NOUN dz010p12h95 8 13 binding bind VERB dz010p12h95 8 14 sites site NOUN dz010p12h95 8 15 in in ADP dz010p12h95 8 16 the the DET dz010p12h95 8 17 mcf7 mcf7 NOUN dz010p12h95 8 18 genome genome NOUN dz010p12h95 8 19 . . PUNCT dz010p12h95 9 1 i i PRON dz010p12h95 9 2 discovered discover VERB dz010p12h95 9 3 transcriptomic transcriptomic ADJ dz010p12h95 9 4 and and CCONJ dz010p12h95 9 5 genomic genomic ADJ dz010p12h95 9 6 changes change NOUN dz010p12h95 9 7 that that PRON dz010p12h95 9 8 promote promote VERB dz010p12h95 9 9 lower low ADJ dz010p12h95 9 10 survival survival NOUN dz010p12h95 9 11 in in ADP dz010p12h95 9 12 er+ er+ NOUN dz010p12h95 9 13 breast breast NOUN dz010p12h95 9 14 cancer cancer NOUN dz010p12h95 9 15 patients patient NOUN dz010p12h95 9 16 receiving receive VERB dz010p12h95 9 17 tamoxifen tamoxifen NOUN dz010p12h95 9 18 . . PUNCT dz010p12h95 10 1 these these DET dz010p12h95 10 2 data datum NOUN dz010p12h95 10 3 identified identify VERB dz010p12h95 10 4 key key ADJ dz010p12h95 10 5 pathways pathway NOUN dz010p12h95 10 6 altered alter VERB dz010p12h95 10 7 in in ADP dz010p12h95 10 8 a a DET dz010p12h95 10 9 znf217 znf217 NOUN dz010p12h95 10 10 - - PUNCT dz010p12h95 10 11 dependent dependent ADJ dz010p12h95 10 12 manner manner NOUN dz010p12h95 10 13 after after ADP dz010p12h95 10 14 nrg1 nrg1 PROPN dz010p12h95 10 15 induction induction NOUN dz010p12h95 10 16 . . PUNCT dz010p12h95 11 1 through through ADP dz010p12h95 11 2 integration integration NOUN dz010p12h95 11 3 of of ADP dz010p12h95 11 4 er er INTJ dz010p12h95 11 5 chip chip NOUN dz010p12h95 11 6 - - PUNCT dz010p12h95 11 7 seq seq PROPN dz010p12h95 11 8 & & CCONJ dz010p12h95 11 9 amp amp PROPN dz010p12h95 11 10 ; ; PUNCT dz010p12h95 11 11 znf217 znf217 NOUN dz010p12h95 11 12 cut&run cut&run ADJ dz010p12h95 11 13 data datum NOUN dz010p12h95 11 14 , , PUNCT dz010p12h95 11 15 i i PRON dz010p12h95 11 16 identified identify VERB dz010p12h95 11 17 pck1 pck1 NOUN dz010p12h95 11 18 and and CCONJ dz010p12h95 11 19 phgdh phgdh PROPN dz010p12h95 11 20 as as ADP dz010p12h95 11 21 two two NUM dz010p12h95 11 22 novel novel NOUN dz010p12h95 11 23 inducers inducer NOUN dz010p12h95 11 24 of of ADP dz010p12h95 11 25 tamoxifen tamoxifen NOUN dz010p12h95 11 26 resistance resistance NOUN dz010p12h95 11 27 that that SCONJ dz010p12h95 11 28 rewire rewire NOUN dz010p12h95 11 29 metabolism metabolism NOUN dz010p12h95 11 30 . . PUNCT dz010p12h95 12 1 both both PRON dz010p12h95 12 2 can can AUX dz010p12h95 12 3 drive drive VERB dz010p12h95 12 4 endocrine endocrine NOUN dz010p12h95 12 5 therapy therapy NOUN dz010p12h95 12 6 resistance resistance NOUN dz010p12h95 12 7 in in ADP dz010p12h95 12 8 cell cell NOUN dz010p12h95 12 9 culture culture NOUN dz010p12h95 12 10 . . PUNCT dz010p12h95 13 1 pck1 pck1 NOUN dz010p12h95 13 2 deficiency deficiency NOUN dz010p12h95 13 3 reduces reduce VERB dz010p12h95 13 4 tumor tumor NOUN dz010p12h95 13 5 burden burden NOUN dz010p12h95 13 6 in in ADP dz010p12h95 13 7 vivo vivo PROPN dz010p12h95 13 8 in in ADP dz010p12h95 13 9 mouse mouse PROPN dz010p12h95 13 10 pymt pymt PROPN dz010p12h95 13 11 mammary mammary ADJ dz010p12h95 13 12 cancer cancer NOUN dz010p12h95 13 13 cells cell NOUN dz010p12h95 13 14 ± ± PROPN dz010p12h95 13 15 shrna shrna PROPN dz010p12h95 13 16 pck1 pck1 PROPN dz010p12h95 13 17 knockdown knockdown NOUN dz010p12h95 13 18 . . PUNCT dz010p12h95 14 1 significantly significantly ADV dz010p12h95 14 2 , , PUNCT dz010p12h95 14 3 tumor tumor NOUN dz010p12h95 14 4 overexpression overexpression NOUN dz010p12h95 14 5 of of ADP dz010p12h95 14 6 pck1 pck1 PROPN dz010p12h95 14 7 made make VERB dz010p12h95 14 8 tumors tumor NOUN dz010p12h95 14 9 resistant resistant ADJ dz010p12h95 14 10 to to PART dz010p12h95 14 11 tamoxifen tamoxifen VERB dz010p12h95 14 12 , , PUNCT dz010p12h95 14 13 while while SCONJ dz010p12h95 14 14 the the DET dz010p12h95 14 15 genetic genetic ADJ dz010p12h95 14 16 and and CCONJ dz010p12h95 14 17 pharmacological pharmacological ADJ dz010p12h95 14 18 inhibition inhibition NOUN dz010p12h95 14 19 of of ADP dz010p12h95 14 20 pck1 pck1 PROPN dz010p12h95 14 21 overcame overcome VERB dz010p12h95 14 22 tamoxifen tamoxifen NOUN dz010p12h95 14 23 resistance resistance NOUN dz010p12h95 14 24 in in ADP dz010p12h95 14 25 cell cell NOUN dz010p12h95 14 26 culture culture NOUN dz010p12h95 14 27 and and CCONJ dz010p12h95 14 28 in in ADP dz010p12h95 14 29 vivo.moreover vivo.moreover PROPN dz010p12h95 14 30 , , PUNCT dz010p12h95 14 31 by by ADP dz010p12h95 14 32 analyzing analyze VERB dz010p12h95 14 33 cell cell NOUN dz010p12h95 14 34 culture culture NOUN dz010p12h95 14 35 media medium NOUN dz010p12h95 14 36 in in ADP dz010p12h95 14 37 mcf7 mcf7 NOUN dz010p12h95 14 38 cells cell VERB dz010p12h95 14 39 ± ± PROPN dz010p12h95 14 40 sirna sirna PROPN dz010p12h95 14 41 znf217 znf217 PROPN dz010p12h95 14 42 , , PUNCT dz010p12h95 14 43 i i PRON dz010p12h95 14 44 discovered discover VERB dz010p12h95 14 45 that that SCONJ dz010p12h95 14 46 znf217 znf217 NOUN dz010p12h95 14 47 alters alter VERB dz010p12h95 14 48 the the DET dz010p12h95 14 49 cytokine cytokine NOUN dz010p12h95 14 50 / / SYM dz010p12h95 14 51 chemokine chemokine NOUN dz010p12h95 14 52 / / SYM dz010p12h95 14 53 growth growth NOUN dz010p12h95 14 54 factor factor NOUN dz010p12h95 14 55 profile profile NOUN dz010p12h95 14 56 secreted secrete VERB dz010p12h95 14 57 by by ADP dz010p12h95 14 58 er+ er+ NOUN dz010p12h95 14 59 breast breast NOUN dz010p12h95 14 60 cancer cancer NOUN dz010p12h95 14 61 cells cell NOUN dz010p12h95 14 62 . . PUNCT dz010p12h95 15 1 this this PRON dz010p12h95 15 2 suggests suggest VERB dz010p12h95 15 3 a a DET dz010p12h95 15 4 role role NOUN dz010p12h95 15 5 for for ADP dz010p12h95 15 6 znf217 znf217 NOUN dz010p12h95 15 7 in in ADP dz010p12h95 15 8 modulating modulate VERB dz010p12h95 15 9 the the DET dz010p12h95 15 10 immune immune ADJ dz010p12h95 15 11 cell cell NOUN dz010p12h95 15 12 landscape landscape NOUN dz010p12h95 15 13 in in ADP dz010p12h95 15 14 the the DET dz010p12h95 15 15 tumor tumor NOUN dz010p12h95 15 16 microenvironment microenvironment NOUN dz010p12h95 15 17 . . PUNCT dz010p12h95 16 1 together together ADV dz010p12h95 16 2 , , PUNCT dz010p12h95 16 3 my my PRON dz010p12h95 16 4 results result NOUN dz010p12h95 16 5 suggest suggest VERB dz010p12h95 16 6 that that SCONJ dz010p12h95 16 7 zfp217 zfp217 NOUN dz010p12h95 16 8 overexpression overexpression NOUN dz010p12h95 16 9 in in ADP dz010p12h95 16 10 er+ er+ NOUN dz010p12h95 16 11 breast breast NOUN dz010p12h95 16 12 cancer cancer NOUN dz010p12h95 16 13 cells cell NOUN dz010p12h95 16 14 causes cause VERB dz010p12h95 16 15 endocrine endocrine NOUN dz010p12h95 16 16 therapy therapy NOUN dz010p12h95 16 17 resistance resistance NOUN dz010p12h95 16 18 and and CCONJ dz010p12h95 16 19 that that SCONJ dz010p12h95 16 20 growth growth NOUN dz010p12h95 16 21 factor factor NOUN dz010p12h95 16 22 induction induction NOUN dz010p12h95 16 23 via via ADP dz010p12h95 16 24 nrg1 nrg1 PROPN dz010p12h95 16 25 induces induce VERB dz010p12h95 16 26 non non ADJ dz010p12h95 16 27 - - ADJ dz010p12h95 16 28 canonical canonical ADJ dz010p12h95 16 29 er er INTJ dz010p12h95 16 30 binding bind VERB dz010p12h95 16 31 to to ADP dz010p12h95 16 32 the the DET dz010p12h95 16 33 genome genome NOUN dz010p12h95 16 34 and and CCONJ dz010p12h95 16 35 a a DET dz010p12h95 16 36 znf217 znf217 NOUN dz010p12h95 16 37 - - PUNCT dz010p12h95 16 38 dependent dependent ADJ dz010p12h95 16 39 gene gene NOUN dz010p12h95 16 40 expression expression NOUN dz010p12h95 16 41 signature signature NOUN dz010p12h95 16 42 . . PUNCT dz010p12h95 17 1 i i PRON dz010p12h95 17 2 have have AUX dz010p12h95 17 3 identified identify VERB dz010p12h95 17 4 new new ADJ dz010p12h95 17 5 targets target NOUN dz010p12h95 17 6 that that PRON dz010p12h95 17 7 are be AUX dz010p12h95 17 8 regulated regulate VERB dz010p12h95 17 9 by by ADP dz010p12h95 17 10 znf217 znf217 PROPN dz010p12h95 17 11 and and CCONJ dz010p12h95 17 12 nrg1 nrg1 PROPN dz010p12h95 17 13 signaling signal VERB dz010p12h95 17 14 and and CCONJ dz010p12h95 17 15 a a DET dz010p12h95 17 16 possible possible ADJ dz010p12h95 17 17 new new ADJ dz010p12h95 17 18 role role NOUN dz010p12h95 17 19 for for ADP dz010p12h95 17 20 znf217 znf217 NOUN dz010p12h95 17 21 in in ADP dz010p12h95 17 22 regulating regulate VERB dz010p12h95 17 23 the the DET dz010p12h95 17 24 crosstalk crosstalk NOUN dz010p12h95 17 25 between between ADP dz010p12h95 17 26 er+ er+ NOUN dz010p12h95 17 27 breast breast NOUN dz010p12h95 17 28 cancer cancer NOUN dz010p12h95 17 29 cells cell NOUN dz010p12h95 17 30 and and CCONJ dz010p12h95 17 31 immune immune ADJ dz010p12h95 17 32 cells cell NOUN dz010p12h95 17 33 . . PUNCT dz010p12h95 18 1 this this DET dz010p12h95 18 2 study study NOUN dz010p12h95 18 3 unraveled unravel VERB dz010p12h95 18 4 new new ADJ dz010p12h95 18 5 mechanisms mechanism NOUN dz010p12h95 18 6 of of ADP dz010p12h95 18 7 endocrine endocrine NOUN dz010p12h95 18 8 therapy therapy NOUN dz010p12h95 18 9 resistance resistance NOUN dz010p12h95 18 10 , , PUNCT dz010p12h95 18 11 unveiling unveil VERB dz010p12h95 18 12 new new ADJ dz010p12h95 18 13 therapeutic therapeutic ADJ dz010p12h95 18 14 options option NOUN dz010p12h95 18 15 for for ADP dz010p12h95 18 16 er+ er+ NOUN dz010p12h95 18 17 breast breast NOUN dz010p12h95 18 18 cancer cancer NOUN dz010p12h95 18 19 patients patient NOUN dz010p12h95 18 20 . . PUNCT