id sid tid token lemma pos dn39x061p5k 1 1 kidney kidney NOUN dn39x061p5k 1 2 disease disease NOUN dn39x061p5k 1 3 is be AUX dn39x061p5k 1 4 the the DET dn39x061p5k 1 5 9th 9th ADJ dn39x061p5k 1 6 leading lead VERB dn39x061p5k 1 7 cause cause NOUN dn39x061p5k 1 8 of of ADP dn39x061p5k 1 9 death death NOUN dn39x061p5k 1 10 in in ADP dn39x061p5k 1 11 the the DET dn39x061p5k 1 12 united united PROPN dn39x061p5k 1 13 states states PROPN dn39x061p5k 1 14 alone alone ADV dn39x061p5k 1 15 and and CCONJ dn39x061p5k 1 16 can can AUX dn39x061p5k 1 17 arise arise VERB dn39x061p5k 1 18 at at ADP dn39x061p5k 1 19 any any DET dn39x061p5k 1 20 stage stage NOUN dn39x061p5k 1 21 in in ADP dn39x061p5k 1 22 life life NOUN dn39x061p5k 1 23 ( ( PUNCT dn39x061p5k 1 24 american american PROPN dn39x061p5k 1 25 kidney kidney PROPN dn39x061p5k 1 26 fund fund PROPN dn39x061p5k 1 27 , , PUNCT dn39x061p5k 1 28 2017 2017 NUM dn39x061p5k 1 29 ) ) PUNCT dn39x061p5k 1 30 . . PUNCT dn39x061p5k 2 1 during during ADP dn39x061p5k 2 2 development development NOUN dn39x061p5k 2 3 , , PUNCT dn39x061p5k 2 4 congenital congenital ADJ dn39x061p5k 2 5 anomalies anomaly NOUN dn39x061p5k 2 6 of of ADP dn39x061p5k 2 7 the the DET dn39x061p5k 2 8 kidney kidney NOUN dn39x061p5k 2 9 and and CCONJ dn39x061p5k 2 10 urinary urinary ADJ dn39x061p5k 2 11 tract tract NOUN dn39x061p5k 2 12 ( ( PUNCT dn39x061p5k 2 13 cakut cakut ADJ dn39x061p5k 2 14 ) ) PUNCT dn39x061p5k 2 15 includes include VERB dn39x061p5k 2 16 a a DET dn39x061p5k 2 17 broad broad ADJ dn39x061p5k 2 18 spectrum spectrum NOUN dn39x061p5k 2 19 of of ADP dn39x061p5k 2 20 malformations malformation NOUN dn39x061p5k 2 21 that that PRON dn39x061p5k 2 22 can can AUX dn39x061p5k 2 23 be be AUX dn39x061p5k 2 24 as as ADV dn39x061p5k 2 25 severe severe ADJ dn39x061p5k 2 26 as as ADP dn39x061p5k 2 27 agenesis agenesis NOUN dn39x061p5k 2 28 , , PUNCT dn39x061p5k 2 29 which which PRON dn39x061p5k 2 30 is be AUX dn39x061p5k 2 31 when when SCONJ dn39x061p5k 2 32 one one NUM dn39x061p5k 2 33 or or CCONJ dn39x061p5k 2 34 both both DET dn39x061p5k 2 35 kidneys kidney NOUN dn39x061p5k 2 36 fail fail VERB dn39x061p5k 2 37 to to PART dn39x061p5k 2 38 develop develop VERB dn39x061p5k 2 39 . . PUNCT dn39x061p5k 3 1 significantly significantly ADV dn39x061p5k 3 2 , , PUNCT dn39x061p5k 3 3 20 20 NUM dn39x061p5k 3 4 - - SYM dn39x061p5k 3 5 30 30 NUM dn39x061p5k 3 6 % % NOUN dn39x061p5k 3 7 of of ADP dn39x061p5k 3 8 all all DET dn39x061p5k 3 9 prenatally prenatally ADV dn39x061p5k 3 10 identified identify VERB dn39x061p5k 3 11 anomalies anomaly NOUN dn39x061p5k 3 12 can can AUX dn39x061p5k 3 13 be be AUX dn39x061p5k 3 14 categorized categorize VERB dn39x061p5k 3 15 as as ADP dn39x061p5k 3 16 cakut cakut ADJ dn39x061p5k 3 17 , , PUNCT dn39x061p5k 3 18 and and CCONJ dn39x061p5k 3 19 in in ADP dn39x061p5k 3 20 extreme extreme ADJ dn39x061p5k 3 21 cases case NOUN dn39x061p5k 3 22 , , PUNCT dn39x061p5k 3 23 this this DET dn39x061p5k 3 24 type type NOUN dn39x061p5k 3 25 of of ADP dn39x061p5k 3 26 condition condition NOUN dn39x061p5k 3 27 can can AUX dn39x061p5k 3 28 lead lead VERB dn39x061p5k 3 29 to to ADP dn39x061p5k 3 30 renal renal ADJ dn39x061p5k 3 31 failure failure NOUN dn39x061p5k 3 32 or or CCONJ dn39x061p5k 3 33 the the DET dn39x061p5k 3 34 premature premature ADJ dn39x061p5k 3 35 death death NOUN dn39x061p5k 3 36 of of ADP dn39x061p5k 3 37 the the DET dn39x061p5k 3 38 fetus fetus NOUN dn39x061p5k 3 39 . . PUNCT dn39x061p5k 4 1 alternately alternately ADV dn39x061p5k 4 2 , , PUNCT dn39x061p5k 4 3 once once SCONJ dn39x061p5k 4 4 the the DET dn39x061p5k 4 5 kidney kidney NOUN dn39x061p5k 4 6 is be AUX dn39x061p5k 4 7 fully fully ADV dn39x061p5k 4 8 formed form VERB dn39x061p5k 4 9 , , PUNCT dn39x061p5k 4 10 it it PRON dn39x061p5k 4 11 can can AUX dn39x061p5k 4 12 undergo undergo VERB dn39x061p5k 4 13 insults insult NOUN dn39x061p5k 4 14 resulting result VERB dn39x061p5k 4 15 in in ADP dn39x061p5k 4 16 acute acute ADJ dn39x061p5k 4 17 kidney kidney NOUN dn39x061p5k 4 18 injury injury NOUN dn39x061p5k 4 19 ( ( PUNCT dn39x061p5k 4 20 aki aki PROPN dn39x061p5k 4 21 ) ) PUNCT dn39x061p5k 4 22 . . PUNCT dn39x061p5k 5 1 while while SCONJ dn39x061p5k 5 2 it it PRON dn39x061p5k 5 3 has have AUX dn39x061p5k 5 4 been be AUX dn39x061p5k 5 5 documented document VERB dn39x061p5k 5 6 that that SCONJ dn39x061p5k 5 7 a a DET dn39x061p5k 5 8 limited limited ADJ dn39x061p5k 5 9 degree degree NOUN dn39x061p5k 5 10 of of ADP dn39x061p5k 5 11 regeneration regeneration NOUN dn39x061p5k 5 12 can can AUX dn39x061p5k 5 13 occur occur VERB dn39x061p5k 5 14 after after ADP dn39x061p5k 5 15 aki aki PROPN dn39x061p5k 5 16 , , PUNCT dn39x061p5k 5 17 continued continue VERB dn39x061p5k 5 18 damage damage NOUN dn39x061p5k 5 19 to to ADP dn39x061p5k 5 20 the the DET dn39x061p5k 5 21 kidney kidney NOUN dn39x061p5k 5 22 will will AUX dn39x061p5k 5 23 lead lead VERB dn39x061p5k 5 24 to to ADP dn39x061p5k 5 25 end end NOUN dn39x061p5k 5 26 stage stage NOUN dn39x061p5k 5 27 renal renal ADJ dn39x061p5k 5 28 disease disease NOUN dn39x061p5k 5 29 ( ( PUNCT dn39x061p5k 5 30 esrd esrd PROPN dn39x061p5k 5 31 ) ) PUNCT dn39x061p5k 5 32 , , PUNCT dn39x061p5k 5 33 ultimately ultimately ADV dn39x061p5k 5 34 requiring require VERB dn39x061p5k 5 35 a a DET dn39x061p5k 5 36 lifetime lifetime NOUN dn39x061p5k 5 37 of of ADP dn39x061p5k 5 38 dialysis dialysis NOUN dn39x061p5k 5 39 or or CCONJ dn39x061p5k 5 40 a a DET dn39x061p5k 5 41 kidney kidney NOUN dn39x061p5k 5 42 transplant transplant NOUN dn39x061p5k 5 43 for for ADP dn39x061p5k 5 44 survival survival NOUN dn39x061p5k 5 45 . . PUNCT dn39x061p5k 6 1 even even ADV dn39x061p5k 6 2 so so ADV dn39x061p5k 6 3 , , PUNCT dn39x061p5k 6 4 regardless regardless ADV dn39x061p5k 6 5 of of ADP dn39x061p5k 6 6 the the DET dn39x061p5k 6 7 developmental developmental ADJ dn39x061p5k 6 8 or or CCONJ dn39x061p5k 6 9 post post ADJ dn39x061p5k 6 10 - - ADJ dn39x061p5k 6 11 natal natal ADJ dn39x061p5k 6 12 origins origin NOUN dn39x061p5k 6 13 of of ADP dn39x061p5k 6 14 kidney kidney NOUN dn39x061p5k 6 15 disease disease NOUN dn39x061p5k 6 16 , , PUNCT dn39x061p5k 6 17 the the DET dn39x061p5k 6 18 commonality commonality NOUN dn39x061p5k 6 19 of of ADP dn39x061p5k 6 20 these these DET dn39x061p5k 6 21 debilitating debilitate VERB dn39x061p5k 6 22 states state NOUN dn39x061p5k 6 23 is be AUX dn39x061p5k 6 24 dysfunction dysfunction NOUN dn39x061p5k 6 25 of of ADP dn39x061p5k 6 26 the the DET dn39x061p5k 6 27 nephrons nephron NOUN dn39x061p5k 6 28 , , PUNCT dn39x061p5k 6 29 which which PRON dn39x061p5k 6 30 are be AUX dn39x061p5k 6 31 the the DET dn39x061p5k 6 32 functional functional ADJ dn39x061p5k 6 33 units unit NOUN dn39x061p5k 6 34 of of ADP dn39x061p5k 6 35 the the DET dn39x061p5k 6 36 kidney kidney NOUN dn39x061p5k 6 37 ( ( PUNCT dn39x061p5k 6 38 mccampbell mccampbell PROPN dn39x061p5k 6 39 and and CCONJ dn39x061p5k 6 40 wingert wingert PROPN dn39x061p5k 6 41 , , PUNCT dn39x061p5k 6 42 2012 2012 NUM dn39x061p5k 6 43 ) ) PUNCT dn39x061p5k 6 44 . . PUNCT dn39x061p5k 7 1 each each DET dn39x061p5k 7 2 nephron nephron NOUN dn39x061p5k 7 3 is be AUX dn39x061p5k 7 4 characterized characterize VERB dn39x061p5k 7 5 by by ADP dn39x061p5k 7 6 a a DET dn39x061p5k 7 7 blood blood NOUN dn39x061p5k 7 8 filter filter NOUN dn39x061p5k 7 9 connected connect VERB dn39x061p5k 7 10 to to ADP dn39x061p5k 7 11 an an DET dn39x061p5k 7 12 epithelial epithelial ADJ dn39x061p5k 7 13 tubule tubule NOUN dn39x061p5k 7 14 consisting consist VERB dn39x061p5k 7 15 of of ADP dn39x061p5k 7 16 a a DET dn39x061p5k 7 17 series series NOUN dn39x061p5k 7 18 of of ADP dn39x061p5k 7 19 proximal proximal ADJ dn39x061p5k 7 20 and and CCONJ dn39x061p5k 7 21 distal distal ADJ dn39x061p5k 7 22 segments segment NOUN dn39x061p5k 7 23 that that PRON dn39x061p5k 7 24 are be AUX dn39x061p5k 7 25 responsible responsible ADJ dn39x061p5k 7 26 for for ADP dn39x061p5k 7 27 the the DET dn39x061p5k 7 28 essential essential ADJ dn39x061p5k 7 29 tasks task NOUN dn39x061p5k 7 30 of of ADP dn39x061p5k 7 31 the the DET dn39x061p5k 7 32 kidney kidney NOUN dn39x061p5k 7 33 , , PUNCT dn39x061p5k 7 34 including include VERB dn39x061p5k 7 35 nutrient nutrient NOUN dn39x061p5k 7 36 reabsorption reabsorption NOUN dn39x061p5k 7 37 and and CCONJ dn39x061p5k 7 38 ph ph NOUN dn39x061p5k 7 39 regulation regulation NOUN dn39x061p5k 7 40 . . PUNCT dn39x061p5k 8 1 consequently consequently ADV dn39x061p5k 8 2 , , PUNCT dn39x061p5k 8 3 our our PRON dn39x061p5k 8 4 overarching overarch VERB dn39x061p5k 8 5 goal goal NOUN dn39x061p5k 8 6 is be AUX dn39x061p5k 8 7 to to PART dn39x061p5k 8 8 delineate delineate VERB dn39x061p5k 8 9 the the DET dn39x061p5k 8 10 genetic genetic ADJ dn39x061p5k 8 11 and and CCONJ dn39x061p5k 8 12 molecular molecular ADJ dn39x061p5k 8 13 mechanisms mechanism NOUN dn39x061p5k 8 14 that that PRON dn39x061p5k 8 15 regulate regulate VERB dn39x061p5k 8 16 the the DET dn39x061p5k 8 17 specification specification NOUN dn39x061p5k 8 18 of of ADP dn39x061p5k 8 19 these these DET dn39x061p5k 8 20 renal renal ADJ dn39x061p5k 8 21 epithelial epithelial ADJ dn39x061p5k 8 22 cells cell NOUN dn39x061p5k 8 23 as as ADP dn39x061p5k 8 24 a a DET dn39x061p5k 8 25 means means NOUN dn39x061p5k 8 26 to to PART dn39x061p5k 8 27 better well ADV dn39x061p5k 8 28 understand understand VERB dn39x061p5k 8 29 how how SCONJ dn39x061p5k 8 30 these these DET dn39x061p5k 8 31 pathways pathway NOUN dn39x061p5k 8 32 can can AUX dn39x061p5k 8 33 go go VERB dn39x061p5k 8 34 awry awry ADJ dn39x061p5k 8 35 and and CCONJ dn39x061p5k 8 36 result result VERB dn39x061p5k 8 37 in in ADP dn39x061p5k 8 38 kidney kidney NOUN dn39x061p5k 8 39 disease disease NOUN dn39x061p5k 8 40 . . PUNCT dn39x061p5k 9 1 here here ADV dn39x061p5k 9 2 , , PUNCT dn39x061p5k 9 3 we we PRON dn39x061p5k 9 4 reveal reveal VERB dn39x061p5k 9 5 novel novel ADJ dn39x061p5k 9 6 roles role NOUN dn39x061p5k 9 7 for for ADP dn39x061p5k 9 8 the the DET dn39x061p5k 9 9 conserved conserved ADJ dn39x061p5k 9 10 sim1a sim1a PROPN dn39x061p5k 9 11 and and CCONJ dn39x061p5k 9 12 irx2a/3b irx2a/3b ADJ dn39x061p5k 9 13 transcription transcription NOUN dn39x061p5k 9 14 factors factor NOUN dn39x061p5k 9 15 during during ADP dn39x061p5k 9 16 nephrogenesis nephrogenesis NOUN dn39x061p5k 9 17 using use VERB dn39x061p5k 9 18 the the DET dn39x061p5k 9 19 zebrafish zebrafish NOUN dn39x061p5k 9 20 as as ADP dn39x061p5k 9 21 a a DET dn39x061p5k 9 22 vertebrate vertebrate ADJ dn39x061p5k 9 23 model model NOUN dn39x061p5k 9 24 of of ADP dn39x061p5k 9 25 development development NOUN dn39x061p5k 9 26 . . PUNCT dn39x061p5k 10 1 in in ADP dn39x061p5k 10 2 general general ADJ dn39x061p5k 10 3 , , PUNCT dn39x061p5k 10 4 we we PRON dn39x061p5k 10 5 discovered discover VERB dn39x061p5k 10 6 that that SCONJ dn39x061p5k 10 7 sim1a sim1a PROPN dn39x061p5k 10 8 and and CCONJ dn39x061p5k 10 9 irx2a irx2a PROPN dn39x061p5k 10 10 control control VERB dn39x061p5k 10 11 the the DET dn39x061p5k 10 12 formation formation NOUN dn39x061p5k 10 13 of of ADP dn39x061p5k 10 14 the the DET dn39x061p5k 10 15 proximal proximal ADJ dn39x061p5k 10 16 straight straight ADJ dn39x061p5k 10 17 tubule tubule NOUN dn39x061p5k 10 18 ( ( PUNCT dn39x061p5k 10 19 pst pst NOUN dn39x061p5k 10 20 ) ) PUNCT dn39x061p5k 10 21 lineage lineage NOUN dn39x061p5k 10 22 , , PUNCT dn39x061p5k 10 23 while while SCONJ dn39x061p5k 10 24 irx2a/3b irx2a/3b ADJ dn39x061p5k 10 25 participate participate NOUN dn39x061p5k 10 26 in in ADP dn39x061p5k 10 27 the the DET dn39x061p5k 10 28 modulation modulation NOUN dn39x061p5k 10 29 of of ADP dn39x061p5k 10 30 multiciliated multiciliated ADJ dn39x061p5k 10 31 cell cell NOUN dn39x061p5k 10 32 ( ( PUNCT dn39x061p5k 10 33 mcc mcc NOUN dn39x061p5k 10 34 ) ) PUNCT dn39x061p5k 10 35 fates fate NOUN dn39x061p5k 10 36 . . PUNCT dn39x061p5k 11 1 these these DET dn39x061p5k 11 2 findings finding NOUN dn39x061p5k 11 3 not not PART dn39x061p5k 11 4 only only ADV dn39x061p5k 11 5 enhance enhance VERB dn39x061p5k 11 6 our our PRON dn39x061p5k 11 7 current current ADJ dn39x061p5k 11 8 knowledge knowledge NOUN dn39x061p5k 11 9 of of ADP dn39x061p5k 11 10 the the DET dn39x061p5k 11 11 transcriptional transcriptional NOUN dn39x061p5k 11 12 cascade cascade NOUN dn39x061p5k 11 13 that that PRON dn39x061p5k 11 14 directs direct VERB dn39x061p5k 11 15 renal renal ADJ dn39x061p5k 11 16 ontogeny ontogeny ADV dn39x061p5k 11 17 , , PUNCT dn39x061p5k 11 18 but but CCONJ dn39x061p5k 11 19 also also ADV dn39x061p5k 11 20 provide provide VERB dn39x061p5k 11 21 broader broad ADJ dn39x061p5k 11 22 implications implication NOUN dn39x061p5k 11 23 for for ADP dn39x061p5k 11 24 cakut cakut PROPN dn39x061p5k 11 25 and and CCONJ dn39x061p5k 11 26 the the DET dn39x061p5k 11 27 development development NOUN dn39x061p5k 11 28 of of ADP dn39x061p5k 11 29 cell cell NOUN dn39x061p5k 11 30 therapies therapy NOUN dn39x061p5k 11 31 through through ADP dn39x061p5k 11 32 reprogramming reprogramming NOUN dn39x061p5k 11 33 . . PUNCT