id	sid	tid	token	lemma	pos
db78tb12q6h	1	1	antibiotic	antibiotic	ADJ
db78tb12q6h	1	2	resistant	resistant	ADJ
db78tb12q6h	1	3	bacteria	bacteria	NOUN
db78tb12q6h	1	4	pose	pose	VERB
db78tb12q6h	1	5	an	an	DET
db78tb12q6h	1	6	existential	existential	ADJ
db78tb12q6h	1	7	threat	threat	NOUN
db78tb12q6h	1	8	to	to	ADP
db78tb12q6h	1	9	the	the	DET
db78tb12q6h	1	10	modern	modern	ADJ
db78tb12q6h	1	11	healthcare	healthcare	NOUN
db78tb12q6h	1	12	system	system	NOUN
db78tb12q6h	1	13	.	.	PUNCT
db78tb12q6h	2	1	the	the	DET
db78tb12q6h	2	2	degree	degree	NOUN
db78tb12q6h	2	3	and	and	CCONJ
db78tb12q6h	2	4	severity	severity	NOUN
db78tb12q6h	2	5	of	of	ADP
db78tb12q6h	2	6	antibiotic	antibiotic	ADJ
db78tb12q6h	2	7	resistance	resistance	NOUN
db78tb12q6h	2	8	that	that	PRON
db78tb12q6h	2	9	is	be	AUX
db78tb12q6h	2	10	clinically	clinically	ADV
db78tb12q6h	2	11	observed	observe	VERB
db78tb12q6h	2	12	continually	continually	ADV
db78tb12q6h	2	13	rises	rise	VERB
db78tb12q6h	2	14	while	while	SCONJ
db78tb12q6h	2	15	the	the	DET
db78tb12q6h	2	16	development	development	NOUN
db78tb12q6h	2	17	of	of	ADP
db78tb12q6h	2	18	novel	novel	ADJ
db78tb12q6h	2	19	antibiotic	antibiotic	ADJ
db78tb12q6h	2	20	classes	class	NOUN
db78tb12q6h	2	21	remains	remain	VERB
db78tb12q6h	2	22	stagnate	stagnate	ADJ
db78tb12q6h	2	23	.	.	PUNCT
db78tb12q6h	3	1	antibiotic	antibiotic	ADJ
db78tb12q6h	3	2	adjuvant	adjuvant	ADJ
db78tb12q6h	3	3	methodology	methodology	NOUN
db78tb12q6h	3	4	can	can	AUX
db78tb12q6h	3	5	be	be	AUX
db78tb12q6h	3	6	utilized	utilize	VERB
db78tb12q6h	3	7	to	to	PART
db78tb12q6h	3	8	circumvent	circumvent	VERB
db78tb12q6h	3	9	the	the	DET
db78tb12q6h	3	10	arduous	arduous	ADJ
db78tb12q6h	3	11	process	process	NOUN
db78tb12q6h	3	12	of	of	ADP
db78tb12q6h	3	13	novel	novel	ADJ
db78tb12q6h	3	14	antibiotic	antibiotic	ADJ
db78tb12q6h	3	15	development	development	NOUN
db78tb12q6h	3	16	by	by	ADP
db78tb12q6h	3	17	pairing	pair	VERB
db78tb12q6h	3	18	non	non	ADJ
db78tb12q6h	3	19	-	-	ADJ
db78tb12q6h	3	20	antimicrobial	antimicrobial	ADJ
db78tb12q6h	3	21	small	small	ADJ
db78tb12q6h	3	22	molecules	molecule	NOUN
db78tb12q6h	3	23	with	with	ADP
db78tb12q6h	3	24	clinically	clinically	ADV
db78tb12q6h	3	25	available	available	ADJ
db78tb12q6h	3	26	antibiotics	antibiotic	NOUN
db78tb12q6h	3	27	to	to	PART
db78tb12q6h	3	28	defeat	defeat	VERB
db78tb12q6h	3	29	bacterial	bacterial	ADJ
db78tb12q6h	3	30	resistance	resistance	NOUN
db78tb12q6h	3	31	or	or	CCONJ
db78tb12q6h	3	32	potentiate	potentiate	VERB
db78tb12q6h	3	33	a	a	DET
db78tb12q6h	3	34	drug	drug	NOUN
db78tb12q6h	3	35	of	of	ADP
db78tb12q6h	3	36	interest	interest	NOUN
db78tb12q6h	3	37	.	.	PUNCT
db78tb12q6h	4	1	this	this	DET
db78tb12q6h	4	2	work	work	NOUN
db78tb12q6h	4	3	comprises	comprise	VERB
db78tb12q6h	4	4	efforts	effort	NOUN
db78tb12q6h	4	5	to	to	PART
db78tb12q6h	4	6	identify	identify	VERB
db78tb12q6h	4	7	a	a	DET
db78tb12q6h	4	8	diverse	diverse	ADJ
db78tb12q6h	4	9	cohort	cohort	NOUN
db78tb12q6h	4	10	of	of	ADP
db78tb12q6h	4	11	chemical	chemical	ADJ
db78tb12q6h	4	12	scaffolds	scaffold	NOUN
db78tb12q6h	4	13	that	that	PRON
db78tb12q6h	4	14	can	can	AUX
db78tb12q6h	4	15	be	be	AUX
db78tb12q6h	4	16	employed	employ	VERB
db78tb12q6h	4	17	in	in	ADP
db78tb12q6h	4	18	advantageous	advantageous	ADJ
db78tb12q6h	4	19	combinations	combination	NOUN
db78tb12q6h	4	20	with	with	ADP
db78tb12q6h	4	21	colistin	colistin	PROPN
db78tb12q6h	4	22	,	,	PUNCT
db78tb12q6h	4	23	a	a	DET
db78tb12q6h	4	24	polymyxin	polymyxin	ADJ
db78tb12q6h	4	25	antibiotic	antibiotic	NOUN
db78tb12q6h	4	26	,	,	PUNCT
db78tb12q6h	4	27	to	to	PART
db78tb12q6h	4	28	defeat	defeat	VERB
db78tb12q6h	4	29	colistin	colistin	PROPN
db78tb12q6h	4	30	resistance	resistance	NOUN
db78tb12q6h	4	31	and	and	CCONJ
db78tb12q6h	4	32	offset	offset	VERB
db78tb12q6h	4	33	its	its	PRON
db78tb12q6h	4	34	detrimental	detrimental	ADJ
db78tb12q6h	4	35	side	side	NOUN
db78tb12q6h	4	36	effects	effect	NOUN
db78tb12q6h	4	37	.	.	PUNCT
db78tb12q6h	5	1	this	this	DET
db78tb12q6h	5	2	work	work	NOUN
db78tb12q6h	5	3	discloses	disclose	VERB
db78tb12q6h	5	4	numerous	numerous	ADJ
db78tb12q6h	5	5	molecules	molecule	NOUN
db78tb12q6h	5	6	with	with	ADP
db78tb12q6h	5	7	unprecedented	unprecedented	ADJ
db78tb12q6h	5	8	activity	activity	NOUN
db78tb12q6h	5	9	through	through	ADP
db78tb12q6h	5	10	a	a	DET
db78tb12q6h	5	11	comprehensive	comprehensive	ADJ
db78tb12q6h	5	12	screening	screening	NOUN
db78tb12q6h	5	13	of	of	ADP
db78tb12q6h	5	14	an	an	DET
db78tb12q6h	5	15	in	in	ADP
db78tb12q6h	5	16	-	-	PUNCT
db78tb12q6h	5	17	house	house	NOUN
db78tb12q6h	5	18	library	library	NOUN
db78tb12q6h	5	19	of	of	ADP
db78tb12q6h	5	20	nitrogen	nitrogen	PROPN
db78tb12q6h	5	21	-	-	PUNCT
db78tb12q6h	5	22	rich	rich	ADJ
db78tb12q6h	5	23	small	small	ADJ
db78tb12q6h	5	24	molecules	molecule	NOUN
db78tb12q6h	5	25	and	and	CCONJ
db78tb12q6h	5	26	high	high	ADJ
db78tb12q6h	5	27	content	content	NOUN
db78tb12q6h	5	28	drug	drug	NOUN
db78tb12q6h	5	29	repurposing	repurpose	VERB
db78tb12q6h	5	30	efforts	effort	NOUN
db78tb12q6h	5	31	using	use	VERB
db78tb12q6h	5	32	commercially	commercially	ADV
db78tb12q6h	5	33	available	available	ADJ
db78tb12q6h	5	34	chemical	chemical	NOUN
db78tb12q6h	5	35	libraries	library	NOUN
db78tb12q6h	5	36	with	with	ADP
db78tb12q6h	5	37	known	know	VERB
db78tb12q6h	5	38	eukaryotic	eukaryotic	ADJ
db78tb12q6h	5	39	activity	activity	NOUN
db78tb12q6h	5	40	.	.	PUNCT
db78tb12q6h	6	1	before	before	ADP
db78tb12q6h	6	2	the	the	DET
db78tb12q6h	6	3	discovery	discovery	NOUN
db78tb12q6h	6	4	of	of	ADP
db78tb12q6h	6	5	the	the	DET
db78tb12q6h	6	6	mobile	mobile	PROPN
db78tb12q6h	6	7	colistin	colistin	PROPN
db78tb12q6h	6	8	resistance-1	resistance-1	PROPN
db78tb12q6h	6	9	(	(	PUNCT
db78tb12q6h	6	10	mcr-1	mcr-1	X
db78tb12q6h	6	11	)	)	PUNCT
db78tb12q6h	6	12	gene	gene	NOUN
db78tb12q6h	6	13	in	in	ADP
db78tb12q6h	6	14	2015	2015	NUM
db78tb12q6h	6	15	,	,	PUNCT
db78tb12q6h	6	16	spontaneous	spontaneous	ADJ
db78tb12q6h	6	17	colistin	colistin	PROPN
db78tb12q6h	6	18	resistance	resistance	NOUN
db78tb12q6h	6	19	was	be	AUX
db78tb12q6h	6	20	found	find	VERB
db78tb12q6h	6	21	only	only	ADV
db78tb12q6h	6	22	in	in	ADP
db78tb12q6h	6	23	environments	environment	NOUN
db78tb12q6h	6	24	with	with	ADP
db78tb12q6h	6	25	intense	intense	ADJ
db78tb12q6h	6	26	selection	selection	NOUN
db78tb12q6h	6	27	pressure	pressure	NOUN
db78tb12q6h	6	28	.	.	PUNCT
db78tb12q6h	7	1	since	since	SCONJ
db78tb12q6h	7	2	that	that	DET
db78tb12q6h	7	3	time	time	NOUN
db78tb12q6h	7	4	,	,	PUNCT
db78tb12q6h	7	5	multiple	multiple	ADJ
db78tb12q6h	7	6	mcr	mcr	ADJ
db78tb12q6h	7	7	plasmid	plasmid	ADJ
db78tb12q6h	7	8	-	-	PUNCT
db78tb12q6h	7	9	borne	bear	VERB
db78tb12q6h	7	10	genes	gene	NOUN
db78tb12q6h	7	11	have	have	AUX
db78tb12q6h	7	12	been	be	AUX
db78tb12q6h	7	13	detected	detect	VERB
db78tb12q6h	7	14	in	in	ADP
db78tb12q6h	7	15	clinical	clinical	ADJ
db78tb12q6h	7	16	isolates	isolate	NOUN
db78tb12q6h	7	17	all	all	ADV
db78tb12q6h	7	18	around	around	ADP
db78tb12q6h	7	19	the	the	DET
db78tb12q6h	7	20	globe	globe	NOUN
db78tb12q6h	7	21	.	.	PUNCT
db78tb12q6h	8	1	as	as	ADP
db78tb12q6h	8	2	such	such	ADJ
db78tb12q6h	8	3	,	,	PUNCT
db78tb12q6h	8	4	screening	screen	VERB
db78tb12q6h	8	5	efforts	effort	NOUN
db78tb12q6h	8	6	were	be	AUX
db78tb12q6h	8	7	aimed	aim	VERB
db78tb12q6h	8	8	at	at	ADP
db78tb12q6h	8	9	reversing	reverse	VERB
db78tb12q6h	8	10	colistin	colistin	PROPN
db78tb12q6h	8	11	resistance	resistance	PROPN
db78tb12q6h	8	12	controlled	control	VERB
db78tb12q6h	8	13	by	by	ADP
db78tb12q6h	8	14	mcr	mcr	ADJ
db78tb12q6h	8	15	genes	gene	NOUN
db78tb12q6h	8	16	and	and	CCONJ
db78tb12q6h	8	17	all	all	DET
db78tb12q6h	8	18	other	other	ADJ
db78tb12q6h	8	19	known	know	VERB
db78tb12q6h	8	20	genetic	genetic	ADJ
db78tb12q6h	8	21	mechanisms	mechanism	NOUN
db78tb12q6h	8	22	.	.	PUNCT
db78tb12q6h	9	1	active	active	ADJ
db78tb12q6h	9	2	scaffolds	scaffold	NOUN
db78tb12q6h	9	3	were	be	AUX
db78tb12q6h	9	4	then	then	ADV
db78tb12q6h	9	5	subjected	subject	VERB
db78tb12q6h	9	6	to	to	ADP
db78tb12q6h	9	7	structure	structure	NOUN
db78tb12q6h	9	8	-	-	PUNCT
db78tb12q6h	9	9	activity	activity	NOUN
db78tb12q6h	9	10	relationship	relationship	NOUN
db78tb12q6h	9	11	(	(	PUNCT
db78tb12q6h	9	12	sar	sar	PROPN
db78tb12q6h	9	13	)	)	PUNCT
db78tb12q6h	9	14	studies	study	NOUN
db78tb12q6h	9	15	in	in	ADP
db78tb12q6h	9	16	efforts	effort	NOUN
db78tb12q6h	9	17	to	to	PART
db78tb12q6h	9	18	optimize	optimize	VERB
db78tb12q6h	9	19	activity	activity	NOUN
db78tb12q6h	9	20	and	and	CCONJ
db78tb12q6h	9	21	minimize	minimize	VERB
db78tb12q6h	9	22	off	off	ADP
db78tb12q6h	9	23	-	-	PUNCT
db78tb12q6h	9	24	target	target	NOUN
db78tb12q6h	9	25	effects	effect	NOUN
db78tb12q6h	9	26	.	.	PUNCT
db78tb12q6h	10	1	specifically	specifically	ADV
db78tb12q6h	10	2	,	,	PUNCT
db78tb12q6h	10	3	sar	sar	PROPN
db78tb12q6h	10	4	studies	study	NOUN
db78tb12q6h	10	5	using	use	VERB
db78tb12q6h	10	6	derivatives	derivative	NOUN
db78tb12q6h	10	7	of	of	ADP
db78tb12q6h	10	8	meridianin	meridianin	PROPN
db78tb12q6h	10	9	d	d	PROPN
db78tb12q6h	10	10	,	,	PUNCT
db78tb12q6h	10	11	a	a	DET
db78tb12q6h	10	12	marine	marine	ADJ
db78tb12q6h	10	13	natural	natural	ADJ
db78tb12q6h	10	14	product	product	NOUN
db78tb12q6h	10	15	,	,	PUNCT
db78tb12q6h	10	16	identified	identify	VERB
db78tb12q6h	10	17	molecules	molecule	NOUN
db78tb12q6h	10	18	with	with	ADP
db78tb12q6h	10	19	significant	significant	ADJ
db78tb12q6h	10	20	colistin	colistin	PROPN
db78tb12q6h	10	21	adjuvant	adjuvant	ADJ
db78tb12q6h	10	22	activity	activity	NOUN
db78tb12q6h	10	23	in	in	ADP
db78tb12q6h	10	24	gram	gram	ADJ
db78tb12q6h	10	25	-	-	PUNCT
db78tb12q6h	10	26	negative	negative	ADJ
db78tb12q6h	10	27	species	specie	NOUN
db78tb12q6h	10	28	while	while	SCONJ
db78tb12q6h	10	29	simultaneously	simultaneously	ADV
db78tb12q6h	10	30	controlling	control	VERB
db78tb12q6h	10	31	biofilm	biofilm	NOUN
db78tb12q6h	10	32	formation	formation	NOUN
db78tb12q6h	10	33	in	in	ADP
db78tb12q6h	10	34	gram	gram	ADJ
db78tb12q6h	10	35	-	-	PUNCT
db78tb12q6h	10	36	positive	positive	ADJ
db78tb12q6h	10	37	strains	strain	NOUN
db78tb12q6h	10	38	.	.	PUNCT
db78tb12q6h	11	1	additionally	additionally	ADV
db78tb12q6h	11	2	,	,	PUNCT
db78tb12q6h	11	3	sar	sar	PROPN
db78tb12q6h	11	4	studies	study	NOUN
db78tb12q6h	11	5	of	of	ADP
db78tb12q6h	11	6	a	a	DET
db78tb12q6h	11	7	tryptamine	tryptamine	NOUN
db78tb12q6h	11	8	-	-	PUNCT
db78tb12q6h	11	9	based	base	VERB
db78tb12q6h	11	10	molecule	molecule	NOUN
db78tb12q6h	11	11	inspired	inspire	VERB
db78tb12q6h	11	12	by	by	ADP
db78tb12q6h	11	13	the	the	DET
db78tb12q6h	11	14	natural	natural	ADJ
db78tb12q6h	11	15	product	product	NOUN
db78tb12q6h	11	16	oroidin	oroidin	NOUN
db78tb12q6h	11	17	accessed	access	VERB
db78tb12q6h	11	18	molecules	molecule	NOUN
db78tb12q6h	11	19	with	with	ADP
db78tb12q6h	11	20	increased	increase	VERB
db78tb12q6h	11	21	colistin	colistin	PROPN
db78tb12q6h	11	22	synergy	synergy	PROPN
db78tb12q6h	11	23	and	and	CCONJ
db78tb12q6h	11	24	decreased	decrease	VERB
db78tb12q6h	11	25	off	off	ADP
db78tb12q6h	11	26	-	-	PUNCT
db78tb12q6h	11	27	target	target	NOUN
db78tb12q6h	11	28	effects	effect	NOUN
db78tb12q6h	11	29	.	.	PUNCT
db78tb12q6h	12	1	two	two	NUM
db78tb12q6h	12	2	novel	novel	NOUN
db78tb12q6h	12	3	colistin	colistin	PROPN
db78tb12q6h	12	4	adjuvants	adjuvant	NOUN
db78tb12q6h	12	5	were	be	AUX
db78tb12q6h	12	6	then	then	ADV
db78tb12q6h	12	7	discovered	discover	VERB
db78tb12q6h	12	8	from	from	ADP
db78tb12q6h	12	9	a	a	DET
db78tb12q6h	12	10	high	high	ADJ
db78tb12q6h	12	11	content	content	NOUN
db78tb12q6h	12	12	screening	screening	NOUN
db78tb12q6h	12	13	of	of	ADP
db78tb12q6h	12	14	three	three	NUM
db78tb12q6h	12	15	commercially	commercially	ADV
db78tb12q6h	12	16	available	available	ADJ
db78tb12q6h	12	17	eukaryotic	eukaryotic	ADJ
db78tb12q6h	12	18	kinase	kinase	ADJ
db78tb12q6h	12	19	inhibitor	inhibitor	NOUN
db78tb12q6h	12	20	libraries	library	NOUN
db78tb12q6h	12	21	.	.	PUNCT
db78tb12q6h	13	1	these	these	DET
db78tb12q6h	13	2	molecules	molecule	NOUN
db78tb12q6h	13	3	remain	remain	VERB
db78tb12q6h	13	4	some	some	PRON
db78tb12q6h	13	5	of	of	ADP
db78tb12q6h	13	6	the	the	DET
db78tb12q6h	13	7	most	most	ADV
db78tb12q6h	13	8	potent	potent	ADJ
db78tb12q6h	13	9	and	and	CCONJ
db78tb12q6h	13	10	highly	highly	ADV
db78tb12q6h	13	11	versatile	versatile	ADJ
db78tb12q6h	13	12	adjuvants	adjuvant	NOUN
db78tb12q6h	13	13	as	as	ADP
db78tb12q6h	13	14	of	of	ADP
db78tb12q6h	13	15	the	the	DET
db78tb12q6h	13	16	writing	writing	NOUN
db78tb12q6h	13	17	of	of	ADP
db78tb12q6h	13	18	this	this	DET
db78tb12q6h	13	19	work	work	NOUN
db78tb12q6h	13	20	.	.	PUNCT
db78tb12q6h	14	1	this	this	DET
db78tb12q6h	14	2	same	same	ADJ
db78tb12q6h	14	3	methodology	methodology	NOUN
db78tb12q6h	14	4	was	be	AUX
db78tb12q6h	14	5	successfully	successfully	ADV
db78tb12q6h	14	6	applied	apply	VERB
db78tb12q6h	14	7	using	use	VERB
db78tb12q6h	14	8	eukaryotic	eukaryotic	ADJ
db78tb12q6h	14	9	phosphatase	phosphatase	NOUN
db78tb12q6h	14	10	inhibitor	inhibitor	NOUN
db78tb12q6h	14	11	libraries	library	NOUN
db78tb12q6h	14	12	in	in	ADP
db78tb12q6h	14	13	a	a	DET
db78tb12q6h	14	14	study	study	NOUN
db78tb12q6h	14	15	that	that	PRON
db78tb12q6h	14	16	yielded	yield	VERB
db78tb12q6h	14	17	two	two	NUM
db78tb12q6h	14	18	natural	natural	ADJ
db78tb12q6h	14	19	products	product	NOUN
db78tb12q6h	14	20	with	with	ADP
db78tb12q6h	14	21	colistin	colistin	PROPN
db78tb12q6h	14	22	synergy	synergy	PROPN
db78tb12q6h	14	23	.	.	PUNCT
db78tb12q6h	15	1	a	a	DET
db78tb12q6h	15	2	59	59	NUM
db78tb12q6h	15	3	-	-	PUNCT
db78tb12q6h	15	4	member	member	NOUN
db78tb12q6h	15	5	chemical	chemical	PROPN
db78tb12q6h	15	6	library	library	NOUN
db78tb12q6h	15	7	comprised	comprise	VERB
db78tb12q6h	15	8	of	of	ADP
db78tb12q6h	15	9	analogues	analogue	NOUN
db78tb12q6h	15	10	of	of	ADP
db78tb12q6h	15	11	imd	imd	PROPN
db78tb12q6h	15	12	0354	0354	NUM
db78tb12q6h	15	13	,	,	PUNCT
db78tb12q6h	15	14	first	first	ADV
db78tb12q6h	15	15	identified	identify	VERB
db78tb12q6h	15	16	in	in	ADP
db78tb12q6h	15	17	the	the	DET
db78tb12q6h	15	18	kinase	kinase	ADJ
db78tb12q6h	15	19	inhibitor	inhibitor	NOUN
db78tb12q6h	15	20	repurposing	repurpose	VERB
db78tb12q6h	15	21	study	study	NOUN
db78tb12q6h	15	22	,	,	PUNCT
db78tb12q6h	15	23	was	be	AUX
db78tb12q6h	15	24	then	then	ADV
db78tb12q6h	15	25	used	use	VERB
db78tb12q6h	15	26	to	to	PART
db78tb12q6h	15	27	probe	probe	VERB
db78tb12q6h	15	28	for	for	ADP
db78tb12q6h	15	29	additional	additional	ADJ
db78tb12q6h	15	30	bacterial	bacterial	ADJ
db78tb12q6h	15	31	activity	activity	NOUN
db78tb12q6h	15	32	and	and	CCONJ
db78tb12q6h	15	33	determine	determine	VERB
db78tb12q6h	15	34	if	if	SCONJ
db78tb12q6h	15	35	this	this	DET
db78tb12q6h	15	36	structure	structure	NOUN
db78tb12q6h	15	37	can	can	AUX
db78tb12q6h	15	38	be	be	AUX
db78tb12q6h	15	39	honed	hone	VERB
db78tb12q6h	15	40	to	to	PART
db78tb12q6h	15	41	diminish	diminish	VERB
db78tb12q6h	15	42	its	its	PRON
db78tb12q6h	15	43	eukaryotic	eukaryotic	ADJ
db78tb12q6h	15	44	effects	effect	NOUN
db78tb12q6h	15	45	.	.	PUNCT
db78tb12q6h	16	1	this	this	DET
db78tb12q6h	16	2	study	study	NOUN
db78tb12q6h	16	3	describes	describe	VERB
db78tb12q6h	16	4	the	the	DET
db78tb12q6h	16	5	potent	potent	ADJ
db78tb12q6h	16	6	antimicrobial	antimicrobial	ADJ
db78tb12q6h	16	7	activity	activity	NOUN
db78tb12q6h	16	8	of	of	ADP
db78tb12q6h	16	9	these	these	DET
db78tb12q6h	16	10	molecules	molecule	NOUN
db78tb12q6h	16	11	in	in	ADP
db78tb12q6h	16	12	drug	drug	NOUN
db78tb12q6h	16	13	resistant	resistant	ADJ
db78tb12q6h	16	14	gram	gram	NOUN
db78tb12q6h	16	15	-	-	PUNCT
db78tb12q6h	16	16	positive	positive	ADJ
db78tb12q6h	16	17	species	specie	NOUN
db78tb12q6h	16	18	and	and	CCONJ
db78tb12q6h	16	19	establishes	establish	VERB
db78tb12q6h	16	20	that	that	SCONJ
db78tb12q6h	16	21	eukaryotic	eukaryotic	ADJ
db78tb12q6h	16	22	activity	activity	NOUN
db78tb12q6h	16	23	can	can	AUX
db78tb12q6h	16	24	be	be	AUX
db78tb12q6h	16	25	mitigated	mitigate	VERB
db78tb12q6h	16	26	while	while	SCONJ
db78tb12q6h	16	27	maintaining	maintain	VERB
db78tb12q6h	16	28	bacterial	bacterial	ADJ
db78tb12q6h	16	29	activity	activity	NOUN
db78tb12q6h	16	30	.	.	PUNCT
db78tb12q6h	17	1	throughout	throughout	ADP
db78tb12q6h	17	2	all	all	PRON
db78tb12q6h	17	3	of	of	ADP
db78tb12q6h	17	4	these	these	DET
db78tb12q6h	17	5	studies	study	NOUN
db78tb12q6h	17	6	,	,	PUNCT
db78tb12q6h	17	7	multiple	multiple	ADJ
db78tb12q6h	17	8	methods	method	NOUN
db78tb12q6h	17	9	are	be	AUX
db78tb12q6h	17	10	applied	apply	VERB
db78tb12q6h	17	11	to	to	PART
db78tb12q6h	17	12	examine	examine	VERB
db78tb12q6h	17	13	the	the	DET
db78tb12q6h	17	14	underlying	underlie	VERB
db78tb12q6h	17	15	mechanism	mechanism	NOUN
db78tb12q6h	17	16	of	of	ADP
db78tb12q6h	17	17	action	action	NOUN
db78tb12q6h	17	18	and	and	CCONJ
db78tb12q6h	17	19	potential	potential	ADJ
db78tb12q6h	17	20	pharmaceutical	pharmaceutical	ADJ
db78tb12q6h	17	21	liabilities	liability	NOUN
db78tb12q6h	17	22	of	of	ADP
db78tb12q6h	17	23	bioactive	bioactive	ADJ
db78tb12q6h	17	24	compounds	compound	NOUN
db78tb12q6h	17	25	.	.	PUNCT
db78tb12q6h	18	1	lipid	lipid	NOUN
db78tb12q6h	18	2	a	a	DET
db78tb12q6h	18	3	mass	mass	NOUN
db78tb12q6h	18	4	spectrometry	spectrometry	NOUN
db78tb12q6h	18	5	was	be	AUX
db78tb12q6h	18	6	utilized	utilize	VERB
db78tb12q6h	18	7	to	to	PART
db78tb12q6h	18	8	detect	detect	VERB
db78tb12q6h	18	9	changes	change	NOUN
db78tb12q6h	18	10	in	in	ADP
db78tb12q6h	18	11	the	the	DET
db78tb12q6h	18	12	colistin	colistin	PROPN
db78tb12q6h	18	13	resistant	resistant	PROPN
db78tb12q6h	18	14	phenotype	phenotype	NOUN
db78tb12q6h	18	15	,	,	PUNCT
db78tb12q6h	18	16	while	while	SCONJ
db78tb12q6h	18	17	quantitative	quantitative	ADJ
db78tb12q6h	18	18	pcr	pcr	NOUN
db78tb12q6h	18	19	(	(	PUNCT
db78tb12q6h	18	20	qpcr	qpcr	PROPN
db78tb12q6h	18	21	)	)	PUNCT
db78tb12q6h	18	22	revealed	reveal	VERB
db78tb12q6h	18	23	significant	significant	ADJ
db78tb12q6h	18	24	changes	change	NOUN
db78tb12q6h	18	25	in	in	ADP
db78tb12q6h	18	26	the	the	DET
db78tb12q6h	18	27	expression	expression	NOUN
db78tb12q6h	18	28	of	of	ADP
db78tb12q6h	18	29	genes	gene	NOUN
db78tb12q6h	18	30	involved	involve	VERB
db78tb12q6h	18	31	in	in	ADP
db78tb12q6h	18	32	resistance	resistance	NOUN
db78tb12q6h	18	33	pathways	pathway	NOUN
db78tb12q6h	18	34	.	.	PUNCT
db78tb12q6h	19	1	the	the	DET
db78tb12q6h	19	2	eukaryotic	eukaryotic	ADJ
db78tb12q6h	19	3	toxicity	toxicity	NOUN
db78tb12q6h	19	4	of	of	ADP
db78tb12q6h	19	5	each	each	DET
db78tb12q6h	19	6	active	active	ADJ
db78tb12q6h	19	7	structure	structure	NOUN
db78tb12q6h	19	8	co	co	NOUN
db78tb12q6h	19	9	-	-	VERB
db78tb12q6h	19	10	dosed	dosed	ADJ
db78tb12q6h	19	11	with	with	ADP
db78tb12q6h	19	12	colistin	colistin	PROPN
db78tb12q6h	19	13	was	be	AUX
db78tb12q6h	19	14	determined	determine	VERB
db78tb12q6h	19	15	in	in	ADP
db78tb12q6h	19	16	tissue	tissue	NOUN
db78tb12q6h	19	17	culture	culture	NOUN
db78tb12q6h	19	18	to	to	PART
db78tb12q6h	19	19	preempt	preempt	VERB
db78tb12q6h	19	20	a	a	DET
db78tb12q6h	19	21	potentially	potentially	ADV
db78tb12q6h	19	22	toxic	toxic	ADJ
db78tb12q6h	19	23	combination	combination	NOUN
db78tb12q6h	19	24	.	.	PUNCT
db78tb12q6h	20	1	in	in	ADP
db78tb12q6h	20	2	all	all	PRON
db78tb12q6h	20	3	,	,	PUNCT
db78tb12q6h	20	4	the	the	DET
db78tb12q6h	20	5	studies	study	NOUN
db78tb12q6h	20	6	that	that	PRON
db78tb12q6h	20	7	comprise	comprise	VERB
db78tb12q6h	20	8	this	this	DET
db78tb12q6h	20	9	work	work	NOUN
db78tb12q6h	20	10	are	be	AUX
db78tb12q6h	20	11	aimed	aim	VERB
db78tb12q6h	20	12	towards	towards	ADP
db78tb12q6h	20	13	the	the	DET
db78tb12q6h	20	14	development	development	NOUN
db78tb12q6h	20	15	of	of	ADP
db78tb12q6h	20	16	viable	viable	ADJ
db78tb12q6h	20	17	drug	drug	NOUN
db78tb12q6h	20	18	candidates	candidate	NOUN
db78tb12q6h	20	19	that	that	PRON
db78tb12q6h	20	20	can	can	AUX
db78tb12q6h	20	21	become	become	VERB
db78tb12q6h	20	22	a	a	DET
db78tb12q6h	20	23	powerful	powerful	ADJ
db78tb12q6h	20	24	new	new	ADJ
db78tb12q6h	20	25	tool	tool	NOUN
db78tb12q6h	20	26	within	within	ADP
db78tb12q6h	20	27	the	the	DET
db78tb12q6h	20	28	clinical	clinical	ADJ
db78tb12q6h	20	29	arsenal	arsenal	NOUN
db78tb12q6h	20	30	to	to	PART
db78tb12q6h	20	31	combat	combat	VERB
db78tb12q6h	20	32	the	the	DET
db78tb12q6h	20	33	continual	continual	ADJ
db78tb12q6h	20	34	rise	rise	NOUN
db78tb12q6h	20	35	of	of	ADP
db78tb12q6h	20	36	multi	multi	ADJ
db78tb12q6h	20	37	-	-	ADJ
db78tb12q6h	20	38	drug	drug	ADJ
db78tb12q6h	20	39	resistant	resistant	ADJ
db78tb12q6h	20	40	bacteria	bacteria	NOUN
db78tb12q6h	20	41	.	.	PUNCT