id sid tid token lemma pos d791sf2939m 1 1 diabetic diabetic ADJ d791sf2939m 1 2 patients patient NOUN d791sf2939m 1 3 are be AUX d791sf2939m 1 4 fatally fatally ADV d791sf2939m 1 5 affected affect VERB d791sf2939m 1 6 by by ADP d791sf2939m 1 7 a a DET d791sf2939m 1 8 common common ADJ d791sf2939m 1 9 complication complication NOUN d791sf2939m 1 10 - - PUNCT d791sf2939m 1 11 diabetic diabetic ADJ d791sf2939m 1 12 foot foot NOUN d791sf2939m 1 13 ulcers ulcer NOUN d791sf2939m 1 14 ( ( PUNCT d791sf2939m 1 15 dfus dfus PROPN d791sf2939m 1 16 ) ) PUNCT d791sf2939m 1 17 , , PUNCT d791sf2939m 1 18 or or CCONJ d791sf2939m 1 19 wounds wound NOUN d791sf2939m 1 20 that that PRON d791sf2939m 1 21 are be AUX d791sf2939m 1 22 recalcitrant recalcitrant ADJ d791sf2939m 1 23 to to ADP d791sf2939m 1 24 healing healing NOUN d791sf2939m 1 25 , , PUNCT d791sf2939m 1 26 and and CCONJ d791sf2939m 1 27 more more ADV d791sf2939m 1 28 prone prone ADJ d791sf2939m 1 29 to to ADP d791sf2939m 1 30 the the DET d791sf2939m 1 31 risk risk NOUN d791sf2939m 1 32 of of ADP d791sf2939m 1 33 infection infection NOUN d791sf2939m 1 34 and and CCONJ d791sf2939m 1 35 amputation amputation NOUN d791sf2939m 1 36 . . PUNCT d791sf2939m 2 1 matrix matrix NOUN d791sf2939m 2 2 metalloproteinases metalloproteinase NOUN d791sf2939m 2 3 ( ( PUNCT d791sf2939m 2 4 mmps mmp NOUN d791sf2939m 2 5 ) ) PUNCT d791sf2939m 2 6 are be AUX d791sf2939m 2 7 implicated implicate VERB d791sf2939m 2 8 to to PART d791sf2939m 2 9 play play VERB d791sf2939m 2 10 important important ADJ d791sf2939m 2 11 roles role NOUN d791sf2939m 2 12 in in ADP d791sf2939m 2 13 normal normal ADJ d791sf2939m 2 14 wound wound NOUN d791sf2939m 2 15 healing healing NOUN d791sf2939m 2 16 , , PUNCT d791sf2939m 2 17 as as ADV d791sf2939m 2 18 well well ADV d791sf2939m 2 19 as as ADP d791sf2939m 2 20 in in ADP d791sf2939m 2 21 the the DET d791sf2939m 2 22 pathology pathology NOUN d791sf2939m 2 23 of of ADP d791sf2939m 2 24 dfus dfus PROPN d791sf2939m 2 25 . . PUNCT d791sf2939m 3 1 the the DET d791sf2939m 3 2 challenge challenge NOUN d791sf2939m 3 3 remains remain VERB d791sf2939m 3 4 as as ADP d791sf2939m 3 5 to to ADP d791sf2939m 3 6 which which DET d791sf2939m 3 7 mmp(s mmp(s NOUN d791sf2939m 3 8 ) ) PUNCT d791sf2939m 3 9 among among ADP d791sf2939m 3 10 the the DET d791sf2939m 3 11 24 24 NUM d791sf2939m 3 12 known know VERB d791sf2939m 3 13 human human ADJ d791sf2939m 3 14 variants variant NOUN d791sf2939m 3 15 plays play VERB d791sf2939m 3 16 a a DET d791sf2939m 3 17 role role NOUN d791sf2939m 3 18 in in ADP d791sf2939m 3 19 the the DET d791sf2939m 3 20 ailment ailment NOUN d791sf2939m 3 21 , , PUNCT d791sf2939m 3 22 compounded compound VERB d791sf2939m 3 23 by by ADP d791sf2939m 3 24 the the DET d791sf2939m 3 25 fact fact NOUN d791sf2939m 3 26 that that SCONJ d791sf2939m 3 27 mmps mmp NOUN d791sf2939m 3 28 exist exist VERB d791sf2939m 3 29 in in ADP d791sf2939m 3 30 three three NUM d791sf2939m 3 31 forms form NOUN d791sf2939m 3 32 : : PUNCT d791sf2939m 3 33 the the DET d791sf2939m 3 34 latent latent NOUN d791sf2939m 3 35 , , PUNCT d791sf2939m 3 36 the the DET d791sf2939m 3 37 activated activate VERB d791sf2939m 3 38 in in ADP d791sf2939m 3 39 complex complex NOUN d791sf2939m 3 40 with with ADP d791sf2939m 3 41 protein protein NOUN d791sf2939m 3 42 inhibitors inhibitor NOUN d791sf2939m 3 43 timps timp NOUN d791sf2939m 3 44 , , PUNCT d791sf2939m 3 45 and and CCONJ d791sf2939m 3 46 the the DET d791sf2939m 3 47 activated activate VERB d791sf2939m 3 48 uninhibited uninhibited ADJ d791sf2939m 3 49 form form NOUN d791sf2939m 3 50 . . PUNCT d791sf2939m 4 1 the the DET d791sf2939m 4 2 first first ADJ d791sf2939m 4 3 two two NUM d791sf2939m 4 4 are be AUX d791sf2939m 4 5 catalytically catalytically ADV d791sf2939m 4 6 incompetent incompetent ADJ d791sf2939m 4 7 . . PUNCT d791sf2939m 5 1 active active ADJ d791sf2939m 5 2 mmp-8 mmp-8 ADP d791sf2939m 5 3 and and CCONJ d791sf2939m 5 4 mmp-9 mmp-9 PRON d791sf2939m 5 5 are be AUX d791sf2939m 5 6 the the DET d791sf2939m 5 7 only only ADJ d791sf2939m 5 8 active active ADJ d791sf2939m 5 9 mmps mmp NOUN d791sf2939m 5 10 were be AUX d791sf2939m 5 11 identified identify VERB d791sf2939m 5 12 and and CCONJ d791sf2939m 5 13 quantified quantify VERB d791sf2939m 5 14 in in ADP d791sf2939m 5 15 the the DET d791sf2939m 5 16 wound wound NOUN d791sf2939m 5 17 healing healing NOUN d791sf2939m 5 18 of of ADP d791sf2939m 5 19 both both CCONJ d791sf2939m 5 20 diabetic diabetic ADJ d791sf2939m 5 21 and and CCONJ d791sf2939m 5 22 non non ADJ d791sf2939m 5 23 - - ADJ d791sf2939m 5 24 diabetic diabetic ADJ d791sf2939m 5 25 mice mouse NOUN d791sf2939m 5 26 with with ADP d791sf2939m 5 27 the the DET d791sf2939m 5 28 use use NOUN d791sf2939m 5 29 of of ADP d791sf2939m 5 30 a a DET d791sf2939m 5 31 novel novel ADJ d791sf2939m 5 32 affinity affinity NOUN d791sf2939m 5 33 resin resin NOUN d791sf2939m 5 34 . . PUNCT d791sf2939m 6 1 topical topical ADJ d791sf2939m 6 2 application application NOUN d791sf2939m 6 3 of of ADP d791sf2939m 6 4 nd-336 nd-336 PROPN d791sf2939m 6 5 - - PUNCT d791sf2939m 6 6 a a DET d791sf2939m 6 7 mmp-9 mmp-9 PRON d791sf2939m 6 8 selective selective ADJ d791sf2939m 6 9 inhibitoraccelerates inhibitoraccelerate NOUN d791sf2939m 6 10 wound wound NOUN d791sf2939m 6 11 repair repair NOUN d791sf2939m 6 12 of of ADP d791sf2939m 6 13 diabetic diabetic ADJ d791sf2939m 6 14 mice mouse NOUN d791sf2939m 6 15 , , PUNCT d791sf2939m 6 16 and and CCONJ d791sf2939m 6 17 it it PRON d791sf2939m 6 18 demonstrates demonstrate VERB d791sf2939m 6 19 that that SCONJ d791sf2939m 6 20 upregulation upregulation NOUN d791sf2939m 6 21 of of ADP d791sf2939m 6 22 active active ADJ d791sf2939m 6 23 mmp-9 mmp-9 X d791sf2939m 6 24 is be AUX d791sf2939m 6 25 detrimental detrimental ADJ d791sf2939m 6 26 to to ADP d791sf2939m 6 27 diabetic diabetic ADJ d791sf2939m 6 28 wound wound NOUN d791sf2939m 6 29 healing healing NOUN d791sf2939m 6 30 . . PUNCT d791sf2939m 7 1 topical topical ADJ d791sf2939m 7 2 application application NOUN d791sf2939m 7 3 of of ADP d791sf2939m 7 4 active active ADJ d791sf2939m 7 5 recombinant recombinant NOUN d791sf2939m 7 6 mmp-8 mmp-8 VERB d791sf2939m 7 7 improves improve VERB d791sf2939m 7 8 the the DET d791sf2939m 7 9 rate rate NOUN d791sf2939m 7 10 of of ADP d791sf2939m 7 11 wound wound NOUN d791sf2939m 7 12 closure closure NOUN d791sf2939m 7 13 , , PUNCT d791sf2939m 7 14 indicating indicate VERB d791sf2939m 7 15 that that SCONJ d791sf2939m 7 16 mmp-8 mmp-8 AUX d791sf2939m 7 17 plays play VERB d791sf2939m 7 18 a a DET d791sf2939m 7 19 role role NOUN d791sf2939m 7 20 in in ADP d791sf2939m 7 21 the the DET d791sf2939m 7 22 repair repair NOUN d791sf2939m 7 23 process process NOUN d791sf2939m 7 24 . . PUNCT d791sf2939m 8 1 a a DET d791sf2939m 8 2 combination combination NOUN d791sf2939m 8 3 treatment treatment NOUN d791sf2939m 8 4 of of ADP d791sf2939m 8 5 nd-336 nd-336 PROPN d791sf2939m 8 6 and and CCONJ d791sf2939m 8 7 mmp-8 mmp-8 ADP d791sf2939m 8 8 enhanced enhance VERB d791sf2939m 8 9 wound wound NOUN d791sf2939m 8 10 closure closure NOUN d791sf2939m 8 11 even even ADV d791sf2939m 8 12 further far ADV d791sf2939m 8 13 , , PUNCT d791sf2939m 8 14 in in ADP d791sf2939m 8 15 a a DET d791sf2939m 8 16 strategy strategy NOUN d791sf2939m 8 17 that that PRON d791sf2939m 8 18 holds hold VERB d791sf2939m 8 19 considerable considerable ADJ d791sf2939m 8 20 promise promise NOUN d791sf2939m 8 21 in in ADP d791sf2939m 8 22 healing healing NOUN d791sf2939m 8 23 of of ADP d791sf2939m 8 24 chronic chronic ADJ d791sf2939m 8 25 wounds wound NOUN d791sf2939m 8 26 . . PUNCT d791sf2939m 9 1 topical topical ADJ d791sf2939m 9 2 application application NOUN d791sf2939m 9 3 of of ADP d791sf2939m 9 4 active active ADJ d791sf2939m 9 5 mmp-8 mmp-8 ADP d791sf2939m 9 6 and and CCONJ d791sf2939m 9 7 mmp-13 mmp-13 PROPN d791sf2939m 9 8 ( ( PUNCT d791sf2939m 9 9 another another DET d791sf2939m 9 10 collagenase collagenase NOUN d791sf2939m 9 11 ) ) PUNCT d791sf2939m 9 12 facilitates facilitate VERB d791sf2939m 9 13 wound wound NOUN d791sf2939m 9 14 healing healing NOUN d791sf2939m 9 15 in in ADP d791sf2939m 9 16 both both CCONJ d791sf2939m 9 17 diabetic diabetic ADJ d791sf2939m 9 18 and and CCONJ d791sf2939m 9 19 non non ADJ d791sf2939m 9 20 - - ADJ d791sf2939m 9 21 diabetic diabetic ADJ d791sf2939m 9 22 mice mouse NOUN d791sf2939m 9 23 . . PUNCT d791sf2939m 10 1 mmp-2 mmp-2 PRON d791sf2939m 10 2 and and CCONJ d791sf2939m 10 3 mmp-9 mmp-9 PRON d791sf2939m 10 4 are be AUX d791sf2939m 10 5 gelatinases gelatinase NOUN d791sf2939m 10 6 that that PRON d791sf2939m 10 7 have have AUX d791sf2939m 10 8 been be AUX d791sf2939m 10 9 implicated implicate VERB d791sf2939m 10 10 to to PART d791sf2939m 10 11 play play VERB d791sf2939m 10 12 roles role NOUN d791sf2939m 10 13 in in ADP d791sf2939m 10 14 the the DET d791sf2939m 10 15 process process NOUN d791sf2939m 10 16 of of ADP d791sf2939m 10 17 wound wound NOUN d791sf2939m 10 18 healing healing NOUN d791sf2939m 10 19 . . PUNCT d791sf2939m 11 1 however however ADV d791sf2939m 11 2 , , PUNCT d791sf2939m 11 3 current current ADJ d791sf2939m 11 4 methodology methodology NOUN d791sf2939m 11 5 can can AUX d791sf2939m 11 6 not not PART d791sf2939m 11 7 distinguish distinguish VERB d791sf2939m 11 8 an an DET d791sf2939m 11 9 active active ADJ d791sf2939m 11 10 mmp mmp NOUN d791sf2939m 11 11 among among ADP d791sf2939m 11 12 its its PRON d791sf2939m 11 13 three three NUM d791sf2939m 11 14 forms form NOUN d791sf2939m 11 15 . . PUNCT d791sf2939m 12 1 in in ADP d791sf2939m 12 2 fact fact NOUN d791sf2939m 12 3 , , PUNCT d791sf2939m 12 4 unlike unlike ADP d791sf2939m 12 5 mmp-9 mmp-9 SPACE d791sf2939m 12 6 , , PUNCT d791sf2939m 12 7 mmp-2 mmp-2 ADP d791sf2939m 12 8 most most ADV d791sf2939m 12 9 likely likely ADV d791sf2939m 12 10 has have VERB d791sf2939m 12 11 no no DET d791sf2939m 12 12 role role NOUN d791sf2939m 12 13 in in ADP d791sf2939m 12 14 wound wound NOUN d791sf2939m 12 15 healing healing NOUN d791sf2939m 12 16 because because SCONJ d791sf2939m 12 17 this this DET d791sf2939m 12 18 proteinase proteinase NOUN d791sf2939m 12 19 is be AUX d791sf2939m 12 20 in in ADP d791sf2939m 12 21 complex complex NOUN d791sf2939m 12 22 with with ADP d791sf2939m 12 23 its its PRON d791sf2939m 12 24 inhibitors inhibitor NOUN d791sf2939m 12 25 timps timp NOUN d791sf2939m 12 26 in in ADP d791sf2939m 12 27 vivo vivo PROPN d791sf2939m 12 28 . . PUNCT d791sf2939m 13 1 aclerastide aclerastide PROPN d791sf2939m 13 2 , , PUNCT d791sf2939m 13 3 a a DET d791sf2939m 13 4 peptide peptide NOUN d791sf2939m 13 5 analog analog NOUN d791sf2939m 13 6 of of ADP d791sf2939m 13 7 angiotensin angiotensin PROPN d791sf2939m 13 8 ii ii PROPN d791sf2939m 13 9 , , PUNCT d791sf2939m 13 10 recently recently ADV d791sf2939m 13 11 failed fail VERB d791sf2939m 13 12 in in ADP d791sf2939m 13 13 phase phase PROPN d791sf2939m 13 14 iii iii NUM d791sf2939m 13 15 clinical clinical ADJ d791sf2939m 13 16 trials trial NOUN d791sf2939m 13 17 for for ADP d791sf2939m 13 18 treatment treatment NOUN d791sf2939m 13 19 of of ADP d791sf2939m 13 20 dfus dfus PROPN d791sf2939m 13 21 . . PUNCT d791sf2939m 14 1 topical topical ADJ d791sf2939m 14 2 treatment treatment NOUN d791sf2939m 14 3 of of ADP d791sf2939m 14 4 aclerastide aclerastide ADJ d791sf2939m 14 5 to to ADP d791sf2939m 14 6 wounds wound NOUN d791sf2939m 14 7 of of ADP d791sf2939m 14 8 diabetic diabetic ADJ d791sf2939m 14 9 mice mouse NOUN d791sf2939m 14 10 results result NOUN d791sf2939m 14 11 in in ADP d791sf2939m 14 12 elevated elevated ADJ d791sf2939m 14 13 levels level NOUN d791sf2939m 14 14 of of ADP d791sf2939m 14 15 reactive reactive ADJ d791sf2939m 14 16 oxygen oxygen NOUN d791sf2939m 14 17 species specie NOUN d791sf2939m 14 18 ( ( PUNCT d791sf2939m 14 19 ros ros PROPN d791sf2939m 14 20 ) ) PUNCT d791sf2939m 14 21 and and CCONJ d791sf2939m 14 22 of of ADP d791sf2939m 14 23 active active ADJ d791sf2939m 14 24 mmp-9 mmp-9 SPACE d791sf2939m 14 25 , , PUNCT d791sf2939m 14 26 which which PRON d791sf2939m 14 27 is be AUX d791sf2939m 14 28 likely likely ADJ d791sf2939m 14 29 an an DET d791sf2939m 14 30 important important ADJ d791sf2939m 14 31 contributor contributor NOUN d791sf2939m 14 32 to to ADP d791sf2939m 14 33 the the DET d791sf2939m 14 34 failure failure NOUN d791sf2939m 14 35 of of ADP d791sf2939m 14 36 aclerastide aclerastide ADV d791sf2939m 14 37 in in ADP d791sf2939m 14 38 clinical clinical ADJ d791sf2939m 14 39 trials trial NOUN d791sf2939m 14 40 . . PUNCT d791sf2939m 15 1 using use VERB d791sf2939m 15 2 an an DET d791sf2939m 15 3 affinity affinity NOUN d791sf2939m 15 4 resin resin NOUN d791sf2939m 15 5 that that PRON d791sf2939m 15 6 pulls pull VERB d791sf2939m 15 7 down down ADP d791sf2939m 15 8 only only ADV d791sf2939m 15 9 active active ADJ d791sf2939m 15 10 mmps mmp NOUN d791sf2939m 15 11 coupled couple VERB d791sf2939m 15 12 with with ADP d791sf2939m 15 13 proteomics proteomic NOUN d791sf2939m 15 14 , , PUNCT d791sf2939m 15 15 active active ADJ d791sf2939m 15 16 mmp-8 mmp-8 ADP d791sf2939m 15 17 and and CCONJ d791sf2939m 15 18 mmp-9 mmp-9 PRON d791sf2939m 15 19 are be AUX d791sf2939m 15 20 identified identify VERB d791sf2939m 15 21 and and CCONJ d791sf2939m 15 22 quantified quantify VERB d791sf2939m 15 23 in in ADP d791sf2939m 15 24 patients patient NOUN d791sf2939m 15 25 ' ' PART d791sf2939m 15 26 dfus dfus NOUN d791sf2939m 15 27 . . PUNCT d791sf2939m 16 1 thirty thirty NUM d791sf2939m 16 2 four four NUM d791sf2939m 16 3 - - ADJ d791sf2939m 16 4 fold fold VERB d791sf2939m 16 5 higher high ADJ d791sf2939m 16 6 levels level NOUN d791sf2939m 16 7 of of ADP d791sf2939m 16 8 the the DET d791sf2939m 16 9 detrimental detrimental ADJ d791sf2939m 16 10 active active ADJ d791sf2939m 16 11 mmp-9 mmp-9 VERB d791sf2939m 16 12 are be AUX d791sf2939m 16 13 observed observe VERB d791sf2939m 16 14 in in ADP d791sf2939m 16 15 diabetic diabetic ADJ d791sf2939m 16 16 patients patient NOUN d791sf2939m 16 17 with with ADP d791sf2939m 16 18 the the DET d791sf2939m 16 19 more more ADV d791sf2939m 16 20 severe severe ADJ d791sf2939m 16 21 and and CCONJ d791sf2939m 16 22 infected infected ADJ d791sf2939m 16 23 dfus dfus NOUN d791sf2939m 16 24 compared compare VERB d791sf2939m 16 25 to to ADP d791sf2939m 16 26 control control NOUN d791sf2939m 16 27 tissues tissue NOUN d791sf2939m 16 28 . . PUNCT d791sf2939m 17 1 the the DET d791sf2939m 17 2 enantiomerically enantiomerically ADV d791sf2939m 17 3 pure pure ADJ d791sf2939m 17 4 ( ( PUNCT d791sf2939m 17 5 r)-nd-336 r)-nd-336 ADV d791sf2939m 17 6 exhibits exhibit VERB d791sf2939m 17 7 superior superior ADJ d791sf2939m 17 8 efficacy efficacy NOUN d791sf2939m 17 9 in in ADP d791sf2939m 17 10 inhibiting inhibit VERB d791sf2939m 17 11 mmp-9 mmp-9 SPACE d791sf2939m 17 12 , , PUNCT d791sf2939m 17 13 lowering lower VERB d791sf2939m 17 14 ros ros PROPN d791sf2939m 17 15 while while SCONJ d791sf2939m 17 16 improving improve VERB d791sf2939m 17 17 diabetic diabetic ADJ d791sf2939m 17 18 wound wound NOUN d791sf2939m 17 19 healing healing NOUN d791sf2939m 17 20 significantly significantly ADV d791sf2939m 17 21 . . PUNCT d791sf2939m 18 1 ( ( PUNCT d791sf2939m 18 2 r)-nd-336 r)-nd-336 NOUN d791sf2939m 18 3 represents represent VERB d791sf2939m 18 4 a a DET d791sf2939m 18 5 first first ADJ d791sf2939m 18 6 - - PUNCT d791sf2939m 18 7 in in ADP d791sf2939m 18 8 - - PUNCT d791sf2939m 18 9 class class NOUN d791sf2939m 18 10 therapeutic therapeutic ADJ d791sf2939m 18 11 agent agent NOUN d791sf2939m 18 12 to to PART d791sf2939m 18 13 treat treat VERB d791sf2939m 18 14 dfus dfus PROPN d791sf2939m 18 15 . . PUNCT