id sid tid token lemma pos d791sf28c6s 1 1 the the DET d791sf28c6s 1 2 classic classic ADJ d791sf28c6s 1 3 function function NOUN d791sf28c6s 1 4 of of ADP d791sf28c6s 1 5 vitamin vitamin NOUN d791sf28c6s 1 6 d d NOUN d791sf28c6s 1 7 is be AUX d791sf28c6s 1 8 maintenance maintenance NOUN d791sf28c6s 1 9 of of ADP d791sf28c6s 1 10 calcium calcium NOUN d791sf28c6s 1 11 homeostasis homeostasis NOUN d791sf28c6s 1 12 through through ADP d791sf28c6s 1 13 tight tight ADJ d791sf28c6s 1 14 regulation regulation NOUN d791sf28c6s 1 15 of of ADP d791sf28c6s 1 16 circulating circulate VERB d791sf28c6s 1 17 1,25d 1,25d NUM d791sf28c6s 1 18 via via ADP d791sf28c6s 1 19 synthesis synthesis NOUN d791sf28c6s 1 20 and and CCONJ d791sf28c6s 1 21 degradation degradation NOUN d791sf28c6s 1 22 in in ADP d791sf28c6s 1 23 the the DET d791sf28c6s 1 24 kidney kidney NOUN d791sf28c6s 1 25 . . PUNCT d791sf28c6s 2 1 in in ADP d791sf28c6s 2 2 addition addition NOUN d791sf28c6s 2 3 , , PUNCT d791sf28c6s 2 4 vitamin vitamin NOUN d791sf28c6s 2 5 d d NOUN d791sf28c6s 2 6 signaling signaling NOUN d791sf28c6s 2 7 stimulates stimulate VERB d791sf28c6s 2 8 cellular cellular ADJ d791sf28c6s 2 9 differentiation differentiation NOUN d791sf28c6s 2 10 and and CCONJ d791sf28c6s 2 11 regulates regulate VERB d791sf28c6s 2 12 cell cell NOUN d791sf28c6s 2 13 proliferation proliferation NOUN d791sf28c6s 2 14 and and CCONJ d791sf28c6s 2 15 apoptosis apoptosis NOUN d791sf28c6s 2 16 in in ADP d791sf28c6s 2 17 extra extra ADJ d791sf28c6s 2 18 - - ADJ d791sf28c6s 2 19 renal renal ADJ d791sf28c6s 2 20 tissues tissue NOUN d791sf28c6s 2 21 . . PUNCT d791sf28c6s 3 1 in in ADP d791sf28c6s 3 2 recent recent ADJ d791sf28c6s 3 3 years year NOUN d791sf28c6s 3 4 , , PUNCT d791sf28c6s 3 5 expression expression NOUN d791sf28c6s 3 6 of of ADP d791sf28c6s 3 7 cyp27b1 cyp27b1 NOUN d791sf28c6s 3 8 , , PUNCT d791sf28c6s 3 9 the the DET d791sf28c6s 3 10 enzyme enzyme NOUN d791sf28c6s 3 11 which which PRON d791sf28c6s 3 12 catalyzes catalyze VERB d791sf28c6s 3 13 synthesis synthesis NOUN d791sf28c6s 3 14 of of ADP d791sf28c6s 3 15 the the DET d791sf28c6s 3 16 active active ADJ d791sf28c6s 3 17 metabolite metabolite PROPN d791sf28c6s 3 18 1,25d 1,25d NUM d791sf28c6s 3 19 , , PUNCT d791sf28c6s 3 20 has have AUX d791sf28c6s 3 21 been be AUX d791sf28c6s 3 22 demonstrated demonstrate VERB d791sf28c6s 3 23 in in ADP d791sf28c6s 3 24 cells cell NOUN d791sf28c6s 3 25 derived derive VERB d791sf28c6s 3 26 from from ADP d791sf28c6s 3 27 colon colon NOUN d791sf28c6s 3 28 , , PUNCT d791sf28c6s 3 29 prostate prostate NOUN d791sf28c6s 3 30 and and CCONJ d791sf28c6s 3 31 mammary mammary ADJ d791sf28c6s 3 32 tissue tissue NOUN d791sf28c6s 3 33 , , PUNCT d791sf28c6s 3 34 prompting prompt VERB d791sf28c6s 3 35 the the DET d791sf28c6s 3 36 hypothesis hypothesis NOUN d791sf28c6s 3 37 that that SCONJ d791sf28c6s 3 38 local local ADJ d791sf28c6s 3 39 synthesis synthesis NOUN d791sf28c6s 3 40 of of ADP d791sf28c6s 3 41 1,25d 1,25d NUM d791sf28c6s 3 42 may may AUX d791sf28c6s 3 43 act act VERB d791sf28c6s 3 44 in in ADP d791sf28c6s 3 45 an an DET d791sf28c6s 3 46 autocrine autocrine NOUN d791sf28c6s 3 47 or or CCONJ d791sf28c6s 3 48 paracrine paracrine VERB d791sf28c6s 3 49 fashion fashion NOUN d791sf28c6s 3 50 to to PART d791sf28c6s 3 51 regulate regulate VERB d791sf28c6s 3 52 growth growth NOUN d791sf28c6s 3 53 and and CCONJ d791sf28c6s 3 54 differentiation differentiation NOUN d791sf28c6s 3 55 in in ADP d791sf28c6s 3 56 these these DET d791sf28c6s 3 57 tissues tissue NOUN d791sf28c6s 3 58 . . PUNCT d791sf28c6s 4 1 this this PRON d791sf28c6s 4 2 raises raise VERB d791sf28c6s 4 3 the the DET d791sf28c6s 4 4 possibility possibility NOUN d791sf28c6s 4 5 that that SCONJ d791sf28c6s 4 6 loss loss NOUN d791sf28c6s 4 7 of of ADP d791sf28c6s 4 8 vitamin vitamin NOUN d791sf28c6s 4 9 d d NOUN d791sf28c6s 4 10 signaling signaling NOUN d791sf28c6s 4 11 may may AUX d791sf28c6s 4 12 contribute contribute VERB d791sf28c6s 4 13 to to ADP d791sf28c6s 4 14 the the DET d791sf28c6s 4 15 progression progression NOUN d791sf28c6s 4 16 of of ADP d791sf28c6s 4 17 cancer cancer NOUN d791sf28c6s 4 18 . . PUNCT d791sf28c6s 5 1 therefore therefore ADV d791sf28c6s 5 2 , , PUNCT d791sf28c6s 5 3 these these DET d791sf28c6s 5 4 studies study NOUN d791sf28c6s 5 5 were be AUX d791sf28c6s 5 6 designed design VERB d791sf28c6s 5 7 to to PART d791sf28c6s 5 8 elucidate elucidate VERB d791sf28c6s 5 9 function function NOUN d791sf28c6s 5 10 and and CCONJ d791sf28c6s 5 11 regulation regulation NOUN d791sf28c6s 5 12 of of ADP d791sf28c6s 5 13 the the DET d791sf28c6s 5 14 vitamin vitamin NOUN d791sf28c6s 5 15 d d NOUN d791sf28c6s 5 16 pathway pathway NOUN d791sf28c6s 5 17 in in ADP d791sf28c6s 5 18 both both CCONJ d791sf28c6s 5 19 normal normal ADJ d791sf28c6s 5 20 human human ADJ d791sf28c6s 5 21 mammary mammary ADJ d791sf28c6s 5 22 epithelial epithelial ADJ d791sf28c6s 5 23 cells cell NOUN d791sf28c6s 5 24 ( ( PUNCT d791sf28c6s 5 25 hmec hmec X d791sf28c6s 5 26 ) ) PUNCT d791sf28c6s 5 27 and and CCONJ d791sf28c6s 5 28 mcf-7 mcf-7 VERB d791sf28c6s 5 29 breast breast NOUN d791sf28c6s 5 30 cancer cancer NOUN d791sf28c6s 5 31 cells cell NOUN d791sf28c6s 5 32 . . PUNCT d791sf28c6s 6 1 we we PRON d791sf28c6s 6 2 have have AUX d791sf28c6s 6 3 found find VERB d791sf28c6s 6 4 that that SCONJ d791sf28c6s 6 5 both both DET d791sf28c6s 6 6 mammary mammary ADJ d791sf28c6s 6 7 cell cell NOUN d791sf28c6s 6 8 lines line NOUN d791sf28c6s 6 9 express express VERB d791sf28c6s 6 10 vitamin vitamin NOUN d791sf28c6s 6 11 d d NOUN d791sf28c6s 6 12 pathway pathway NOUN d791sf28c6s 6 13 components component NOUN d791sf28c6s 6 14 and and CCONJ d791sf28c6s 6 15 that that SCONJ d791sf28c6s 6 16 vitamin vitamin NOUN d791sf28c6s 6 17 d d NOUN d791sf28c6s 6 18 signaling signaling NOUN d791sf28c6s 6 19 is be AUX d791sf28c6s 6 20 intact intact ADJ d791sf28c6s 6 21 in in ADP d791sf28c6s 6 22 these these DET d791sf28c6s 6 23 cell cell NOUN d791sf28c6s 6 24 lines line NOUN d791sf28c6s 6 25 . . PUNCT d791sf28c6s 7 1 furthermore furthermore ADV d791sf28c6s 7 2 , , PUNCT d791sf28c6s 7 3 we we PRON d791sf28c6s 7 4 demonstrated demonstrate VERB d791sf28c6s 7 5 internalization internalization NOUN d791sf28c6s 7 6 of of ADP d791sf28c6s 7 7 vitamin vitamin NOUN d791sf28c6s 7 8 d d NOUN d791sf28c6s 7 9 binding bind VERB d791sf28c6s 7 10 protein protein NOUN d791sf28c6s 7 11 ( ( PUNCT d791sf28c6s 7 12 dbp dbp PROPN d791sf28c6s 7 13 ) ) PUNCT d791sf28c6s 7 14 , , PUNCT d791sf28c6s 7 15 cyp27b1 cyp27b1 NOUN d791sf28c6s 7 16 activity activity NOUN d791sf28c6s 7 17 and and CCONJ d791sf28c6s 7 18 1,25d 1,25d NUM d791sf28c6s 7 19 synthesis synthesis NOUN d791sf28c6s 7 20 in in ADP d791sf28c6s 7 21 mammary mammary ADJ d791sf28c6s 7 22 cells cell NOUN d791sf28c6s 7 23 . . PUNCT d791sf28c6s 8 1 these these DET d791sf28c6s 8 2 studies study NOUN d791sf28c6s 8 3 indicate indicate VERB d791sf28c6s 8 4 that that SCONJ d791sf28c6s 8 5 the the DET d791sf28c6s 8 6 normal normal ADJ d791sf28c6s 8 7 mammary mammary ADJ d791sf28c6s 8 8 gland gland NOUN d791sf28c6s 8 9 has have VERB d791sf28c6s 8 10 the the DET d791sf28c6s 8 11 capacity capacity NOUN d791sf28c6s 8 12 to to PART d791sf28c6s 8 13 internalize internalize VERB d791sf28c6s 8 14 and and CCONJ d791sf28c6s 8 15 metabolize metabolize VERB d791sf28c6s 8 16 25d 25d NOUN d791sf28c6s 8 17 - - PUNCT d791sf28c6s 8 18 dbp dbp NOUN d791sf28c6s 8 19 from from ADP d791sf28c6s 8 20 circulation circulation NOUN d791sf28c6s 8 21 . . PUNCT d791sf28c6s 9 1 in in ADP d791sf28c6s 9 2 contrast contrast NOUN d791sf28c6s 9 3 , , PUNCT d791sf28c6s 9 4 dbp dbp NOUN d791sf28c6s 9 5 blunted blunt VERB d791sf28c6s 9 6 the the DET d791sf28c6s 9 7 efficacy efficacy NOUN d791sf28c6s 9 8 of of ADP d791sf28c6s 9 9 25d 25d NOUN d791sf28c6s 9 10 in in ADP d791sf28c6s 9 11 mcf-7 mcf-7 NOUN d791sf28c6s 9 12 cells cell NOUN d791sf28c6s 9 13 , , PUNCT d791sf28c6s 9 14 suggesting suggest VERB d791sf28c6s 9 15 altered altered ADJ d791sf28c6s 9 16 vitamin vitamin NOUN d791sf28c6s 9 17 d d NOUN d791sf28c6s 9 18 signaling signal VERB d791sf28c6s 9 19 in in ADP d791sf28c6s 9 20 breast breast NOUN d791sf28c6s 9 21 cancer cancer NOUN d791sf28c6s 9 22 cells cell NOUN d791sf28c6s 9 23 . . PUNCT d791sf28c6s 10 1 to to PART d791sf28c6s 10 2 investigate investigate VERB d791sf28c6s 10 3 abrogation abrogation NOUN d791sf28c6s 10 4 in in ADP d791sf28c6s 10 5 the the DET d791sf28c6s 10 6 vitamin vitamin NOUN d791sf28c6s 10 7 d d NOUN d791sf28c6s 10 8 pathway pathway NOUN d791sf28c6s 10 9 during during ADP d791sf28c6s 10 10 cancer cancer NOUN d791sf28c6s 10 11 progression progression NOUN d791sf28c6s 10 12 , , PUNCT d791sf28c6s 10 13 we we PRON d791sf28c6s 10 14 utilized utilize VERB d791sf28c6s 10 15 cells cell NOUN d791sf28c6s 10 16 bearing bear VERB d791sf28c6s 10 17 a a DET d791sf28c6s 10 18 series series NOUN d791sf28c6s 10 19 of of ADP d791sf28c6s 10 20 genetic genetic ADJ d791sf28c6s 10 21 manipulations manipulation NOUN d791sf28c6s 10 22 that that PRON d791sf28c6s 10 23 mimic mimic VERB d791sf28c6s 10 24 mutations mutation NOUN d791sf28c6s 10 25 common common ADJ d791sf28c6s 10 26 in in ADP d791sf28c6s 10 27 cancer cancer NOUN d791sf28c6s 10 28 . . PUNCT d791sf28c6s 11 1 although although SCONJ d791sf28c6s 11 2 the the DET d791sf28c6s 11 3 vitamin vitamin NOUN d791sf28c6s 11 4 d d NOUN d791sf28c6s 11 5 signaling signal VERB d791sf28c6s 11 6 pathway pathway NOUN d791sf28c6s 11 7 was be AUX d791sf28c6s 11 8 intact intact ADJ d791sf28c6s 11 9 in in ADP d791sf28c6s 11 10 these these DET d791sf28c6s 11 11 cells cell NOUN d791sf28c6s 11 12 , , PUNCT d791sf28c6s 11 13 lower low ADJ d791sf28c6s 11 14 expression expression NOUN d791sf28c6s 11 15 of of ADP d791sf28c6s 11 16 vdr vdr NOUN d791sf28c6s 11 17 and and CCONJ d791sf28c6s 11 18 decreased decrease VERB d791sf28c6s 11 19 sensitivity sensitivity NOUN d791sf28c6s 11 20 to to ADP d791sf28c6s 11 21 1,25d 1,25d NUM d791sf28c6s 11 22 mediated mediate VERB d791sf28c6s 11 23 growth growth NOUN d791sf28c6s 11 24 regulation regulation NOUN d791sf28c6s 11 25 occurred occur VERB d791sf28c6s 11 26 early early ADV d791sf28c6s 11 27 in in ADP d791sf28c6s 11 28 the the DET d791sf28c6s 11 29 tumorigenic tumorigenic ADJ d791sf28c6s 11 30 process process NOUN d791sf28c6s 11 31 . . PUNCT d791sf28c6s 12 1 collectively collectively ADV d791sf28c6s 12 2 , , PUNCT d791sf28c6s 12 3 our our PRON d791sf28c6s 12 4 work work NOUN d791sf28c6s 12 5 has have AUX d791sf28c6s 12 6 demonstrated demonstrate VERB d791sf28c6s 12 7 that that SCONJ d791sf28c6s 12 8 local local ADJ d791sf28c6s 12 9 synthesis synthesis NOUN d791sf28c6s 12 10 of of ADP d791sf28c6s 12 11 1,25d 1,25d NUM d791sf28c6s 12 12 is be AUX d791sf28c6s 12 13 of of ADP d791sf28c6s 12 14 biological biological ADJ d791sf28c6s 12 15 significance significance NOUN d791sf28c6s 12 16 in in ADP d791sf28c6s 12 17 mammary mammary ADJ d791sf28c6s 12 18 cells cell NOUN d791sf28c6s 12 19 and and CCONJ d791sf28c6s 12 20 that that SCONJ d791sf28c6s 12 21 abrogation abrogation NOUN d791sf28c6s 12 22 in in ADP d791sf28c6s 12 23 the the DET d791sf28c6s 12 24 vitamin vitamin NOUN d791sf28c6s 12 25 d d NOUN d791sf28c6s 12 26 pathway pathway NOUN d791sf28c6s 12 27 may may AUX d791sf28c6s 12 28 contribute contribute VERB d791sf28c6s 12 29 to to ADP d791sf28c6s 12 30 loss loss NOUN d791sf28c6s 12 31 of of ADP d791sf28c6s 12 32 negative negative ADJ d791sf28c6s 12 33 growth growth NOUN d791sf28c6s 12 34 regulation regulation NOUN d791sf28c6s 12 35 by by ADP d791sf28c6s 12 36 1,25d 1,25d NUM d791sf28c6s 12 37 . . PUNCT