id	sid	tid	token	lemma	pos
d504rj45509	1	1	an	an	DET
d504rj45509	1	2	unmet	unmet	ADJ
d504rj45509	1	3	clinical	clinical	ADJ
d504rj45509	1	4	need	need	NOUN
d504rj45509	1	5	exists	exist	VERB
d504rj45509	1	6	for	for	ADP
d504rj45509	1	7	synthetic	synthetic	ADJ
d504rj45509	1	8	bone	bone	NOUN
d504rj45509	1	9	graft	graft	NOUN
d504rj45509	1	10	substitutes	substitute	NOUN
d504rj45509	1	11	which	which	PRON
d504rj45509	1	12	can	can	AUX
d504rj45509	1	13	perform	perform	VERB
d504rj45509	1	14	comparably	comparably	ADV
d504rj45509	1	15	to	to	PART
d504rj45509	1	16	autograft	autograft	VERB
d504rj45509	1	17	in	in	ADP
d504rj45509	1	18	the	the	DET
d504rj45509	1	19	repair	repair	NOUN
d504rj45509	1	20	of	of	ADP
d504rj45509	1	21	bone	bone	NOUN
d504rj45509	1	22	defects.therefore	defects.therefore	NOUN
d504rj45509	1	23	,	,	PUNCT
d504rj45509	1	24	the	the	DET
d504rj45509	1	25	overall	overall	ADJ
d504rj45509	1	26	objective	objective	NOUN
d504rj45509	1	27	of	of	ADP
d504rj45509	1	28	this	this	DET
d504rj45509	1	29	dissertation	dissertation	NOUN
d504rj45509	1	30	was	be	AUX
d504rj45509	1	31	to	to	PART
d504rj45509	1	32	investigate	investigate	VERB
d504rj45509	1	33	the	the	DET
d504rj45509	1	34	design	design	NOUN
d504rj45509	1	35	of	of	ADP
d504rj45509	1	36	hydroxyapatite	hydroxyapatite	PROPN
d504rj45509	1	37	(	(	PUNCT
d504rj45509	1	38	ha)-collagen	ha)-collagen	PROPN
d504rj45509	1	39	scaffolds	scaffold	VERB
d504rj45509	1	40	to	to	PART
d504rj45509	1	41	provide	provide	VERB
d504rj45509	1	42	chemotactic	chemotactic	ADJ
d504rj45509	1	43	and	and	CCONJ
d504rj45509	1	44	mechanical	mechanical	ADJ
d504rj45509	1	45	signals	signal	NOUN
d504rj45509	1	46	which	which	PRON
d504rj45509	1	47	direct	direct	VERB
d504rj45509	1	48	angiogenesis	angiogenesis	NOUN
d504rj45509	1	49	and	and	CCONJ
d504rj45509	1	50	osteogenesis	osteogenesis	NOUN
d504rj45509	1	51	during	during	ADP
d504rj45509	1	52	bone	bone	NOUN
d504rj45509	1	53	regeneration.novel	regeneration.novel	NOUN
d504rj45509	1	54	methods	method	NOUN
d504rj45509	1	55	were	be	AUX
d504rj45509	1	56	developed	develop	VERB
d504rj45509	1	57	for	for	ADP
d504rj45509	1	58	the	the	DET
d504rj45509	1	59	preparation	preparation	NOUN
d504rj45509	1	60	ha	ha	INTJ
d504rj45509	1	61	-	-	PUNCT
d504rj45509	1	62	collagen	collagen	NOUN
d504rj45509	1	63	scaffolds	scaffold	NOUN
d504rj45509	1	64	with	with	ADP
d504rj45509	1	65	improved	improve	VERB
d504rj45509	1	66	architecture	architecture	NOUN
d504rj45509	1	67	and	and	CCONJ
d504rj45509	1	68	mechanical	mechanical	ADJ
d504rj45509	1	69	properties	property	NOUN
d504rj45509	1	70	compared	compare	VERB
d504rj45509	1	71	to	to	ADP
d504rj45509	1	72	conventional	conventional	ADJ
d504rj45509	1	73	freeze	freeze	NOUN
d504rj45509	1	74	-	-	PUNCT
d504rj45509	1	75	dried	dry	VERB
d504rj45509	1	76	scaffolds.the	scaffolds.the	DET
d504rj45509	1	77	effect	effect	NOUN
d504rj45509	1	78	of	of	ADP
d504rj45509	1	79	the	the	DET
d504rj45509	1	80	ha	ha	INTJ
d504rj45509	1	81	volume	volume	NOUN
d504rj45509	1	82	fraction	fraction	NOUN
d504rj45509	1	83	on	on	ADP
d504rj45509	1	84	in	in	ADP
d504rj45509	1	85	vivo	vivo	PROPN
d504rj45509	1	86	angiogenesis	angiogenesis	NOUN
d504rj45509	1	87	and	and	CCONJ
d504rj45509	1	88	osteogenesis	osteogenesis	NOUN
d504rj45509	1	89	was	be	AUX
d504rj45509	1	90	investigated	investigate	VERB
d504rj45509	1	91	after	after	ADP
d504rj45509	1	92	subcutaneous	subcutaneous	ADJ
d504rj45509	1	93	ectopic	ectopic	ADJ
d504rj45509	1	94	implantation	implantation	NOUN
d504rj45509	1	95	in	in	ADP
d504rj45509	1	96	mice.ha	mice.ha	NUM
d504rj45509	1	97	promoted	promote	VERB
d504rj45509	1	98	angiogenesis	angiogenesis	NOUN
d504rj45509	1	99	and	and	CCONJ
d504rj45509	1	100	osteogenesis	osteogenesis	NOUN
d504rj45509	1	101	in	in	ADP
d504rj45509	1	102	collagen	collagen	NOUN
d504rj45509	1	103	scaffolds	scaffold	NOUN
d504rj45509	1	104	that	that	PRON
d504rj45509	1	105	did	do	AUX
d504rj45509	1	106	not	not	PART
d504rj45509	1	107	otherwise	otherwise	ADV
d504rj45509	1	108	exhibit	exhibit	VERB
d504rj45509	1	109	angiogenesis	angiogenesis	NOUN
d504rj45509	1	110	and	and	CCONJ
d504rj45509	1	111	osteogenesis	osteogenesis	NOUN
d504rj45509	1	112	,	,	PUNCT
d504rj45509	1	113	and	and	CCONJ
d504rj45509	1	114	the	the	DET
d504rj45509	1	115	effect	effect	NOUN
d504rj45509	1	116	was	be	AUX
d504rj45509	1	117	dose	dose	VERB
d504rj45509	1	118	dependent.in	dependent.in	NUM
d504rj45509	1	119	a	a	DET
d504rj45509	1	120	subsequent	subsequent	ADJ
d504rj45509	1	121	study	study	NOUN
d504rj45509	1	122	using	use	VERB
d504rj45509	1	123	an	an	DET
d504rj45509	1	124	orthotopic	orthotopic	ADJ
d504rj45509	1	125	critical	critical	ADJ
d504rj45509	1	126	-	-	PUNCT
d504rj45509	1	127	size	size	NOUN
d504rj45509	1	128	femoral	femoral	ADJ
d504rj45509	1	129	defect	defect	NOUN
d504rj45509	1	130	model	model	NOUN
d504rj45509	1	131	in	in	ADP
d504rj45509	1	132	rats	rat	NOUN
d504rj45509	1	133	,	,	PUNCT
d504rj45509	1	134	collagen	collagen	NOUN
d504rj45509	1	135	scaffolds	scaffold	NOUN
d504rj45509	1	136	did	do	AUX
d504rj45509	1	137	not	not	PART
d504rj45509	1	138	exhibit	exhibit	VERB
d504rj45509	1	139	bone	bone	NOUN
d504rj45509	1	140	formation	formation	NOUN
d504rj45509	1	141	,	,	PUNCT
d504rj45509	1	142	while	while	SCONJ
d504rj45509	1	143	ha	ha	PROPN
d504rj45509	1	144	-	-	PUNCT
d504rj45509	1	145	collagen	collagen	NOUN
d504rj45509	1	146	scaffolds	scaffold	NOUN
d504rj45509	1	147	exhibited	exhibit	VERB
d504rj45509	1	148	bone	bone	NOUN
d504rj45509	1	149	formation	formation	NOUN
d504rj45509	1	150	but	but	CCONJ
d504rj45509	1	151	did	do	AUX
d504rj45509	1	152	not	not	PART
d504rj45509	1	153	result	result	VERB
d504rj45509	1	154	in	in	ADP
d504rj45509	1	155	mechanically	mechanically	ADV
d504rj45509	1	156	competent	competent	ADJ
d504rj45509	1	157	union	union	NOUN
d504rj45509	1	158	,	,	PUNCT
d504rj45509	1	159	confirming	confirm	VERB
d504rj45509	1	160	the	the	DET
d504rj45509	1	161	need	need	NOUN
d504rj45509	1	162	to	to	PART
d504rj45509	1	163	augment	augment	VERB
d504rj45509	1	164	scaffolds	scaffold	NOUN
d504rj45509	1	165	with	with	ADP
d504rj45509	1	166	exogenous	exogenous	ADJ
d504rj45509	1	167	growth	growth	NOUN
d504rj45509	1	168	factors	factor	NOUN
d504rj45509	1	169	for	for	ADP
d504rj45509	1	170	functional	functional	ADJ
d504rj45509	1	171	bone	bone	NOUN
d504rj45509	1	172	regeneration.therefore	regeneration.therefore	NOUN
d504rj45509	1	173	,	,	PUNCT
d504rj45509	1	174	scaffolds	scaffold	NOUN
d504rj45509	1	175	were	be	AUX
d504rj45509	1	176	modified	modify	VERB
d504rj45509	1	177	for	for	ADP
d504rj45509	1	178	on	on	ADP
d504rj45509	1	179	-	-	PUNCT
d504rj45509	1	180	demand	demand	NOUN
d504rj45509	1	181	(	(	PUNCT
d504rj45509	1	182	cell	cell	NOUN
d504rj45509	1	183	-	-	PUNCT
d504rj45509	1	184	mediated	mediate	VERB
d504rj45509	1	185	)	)	PUNCT
d504rj45509	1	186	delivery	delivery	NOUN
d504rj45509	1	187	of	of	ADP
d504rj45509	1	188	an	an	DET
d504rj45509	1	189	angiogenic	angiogenic	ADJ
d504rj45509	1	190	(	(	PUNCT
d504rj45509	1	191	vegf	vegf	PROPN
d504rj45509	1	192	)	)	PUNCT
d504rj45509	1	193	and	and	CCONJ
d504rj45509	1	194	osteogenic	osteogenic	ADJ
d504rj45509	1	195	(	(	PUNCT
d504rj45509	1	196	bmp-2	bmp-2	X
d504rj45509	1	197	)	)	PUNCT
d504rj45509	1	198	growth	growth	NOUN
d504rj45509	1	199	factor	factor	NOUN
d504rj45509	1	200	with	with	ADP
d504rj45509	1	201	tunable	tunable	ADJ
d504rj45509	1	202	,	,	PUNCT
d504rj45509	1	203	independent	independent	ADJ
d504rj45509	1	204	control	control	NOUN
d504rj45509	1	205	over	over	ADP
d504rj45509	1	206	the	the	DET
d504rj45509	1	207	dosing	dosing	NOUN
d504rj45509	1	208	and	and	CCONJ
d504rj45509	1	209	release	release	VERB
d504rj45509	1	210	kinetics	kinetic	NOUN
d504rj45509	1	211	of	of	ADP
d504rj45509	1	212	both.growth	both.growth	NOUN
d504rj45509	1	213	factors	factor	NOUN
d504rj45509	1	214	immobilized	immobilize	VERB
d504rj45509	1	215	to	to	ADP
d504rj45509	1	216	collagen	collagen	NOUN
d504rj45509	1	217	fibrils	fibril	NOUN
d504rj45509	1	218	via	via	ADP
d504rj45509	1	219	the	the	DET
d504rj45509	1	220	association	association	NOUN
d504rj45509	1	221	of	of	ADP
d504rj45509	1	222	biotin	biotin	NOUN
d504rj45509	1	223	and	and	CCONJ
d504rj45509	1	224	streptavidin	streptavidin	PROPN
d504rj45509	1	225	exhibited	exhibit	VERB
d504rj45509	1	226	enzymatically	enzymatically	ADV
d504rj45509	1	227	regulated	regulate	VERB
d504rj45509	1	228	release	release	NOUN
d504rj45509	1	229	and	and	CCONJ
d504rj45509	1	230	growth	growth	NOUN
d504rj45509	1	231	factors	factor	NOUN
d504rj45509	1	232	simultaneously	simultaneously	ADV
d504rj45509	1	233	encapsulated	encapsulate	VERB
d504rj45509	1	234	within	within	ADP
d504rj45509	1	235	a	a	DET
d504rj45509	1	236	collagen	collagen	NOUN
d504rj45509	1	237	hydrogel	hydrogel	NOUN
d504rj45509	1	238	filling	fill	VERB
d504rj45509	1	239	pore	pore	NOUN
d504rj45509	1	240	spaces	space	NOUN
d504rj45509	1	241	exhibited	exhibit	VERB
d504rj45509	1	242	sustained	sustain	VERB
d504rj45509	1	243	released.the	released.the	DET
d504rj45509	1	244	effects	effect	NOUN
d504rj45509	1	245	of	of	ADP
d504rj45509	1	246	the	the	DET
d504rj45509	1	247	growth	growth	NOUN
d504rj45509	1	248	factor	factor	NOUN
d504rj45509	1	249	delivery	delivery	NOUN
d504rj45509	1	250	mechanism	mechanism	NOUN
d504rj45509	1	251	on	on	ADP
d504rj45509	1	252	in	in	ADP
d504rj45509	1	253	vivo	vivo	PROPN
d504rj45509	1	254	angiogenesis	angiogenesis	NOUN
d504rj45509	1	255	and	and	CCONJ
d504rj45509	1	256	osteogenesis	osteogenesis	NOUN
d504rj45509	1	257	were	be	AUX
d504rj45509	1	258	investigated	investigate	VERB
d504rj45509	1	259	after	after	ADP
d504rj45509	1	260	subcutaneous	subcutaneous	ADJ
d504rj45509	1	261	ectopic	ectopic	ADJ
d504rj45509	1	262	implantation	implantation	NOUN
d504rj45509	1	263	of	of	ADP
d504rj45509	1	264	ha	ha	INTJ
d504rj45509	1	265	-	-	PUNCT
d504rj45509	1	266	collagen	collagen	NOUN
d504rj45509	1	267	scaffolds	scaffold	NOUN
d504rj45509	1	268	in	in	ADP
d504rj45509	1	269	mice.immobilized	mice.immobilize	VERB
d504rj45509	1	270	vegf	vegf	PROPN
d504rj45509	1	271	promoted	promote	VERB
d504rj45509	1	272	increased	increase	VERB
d504rj45509	1	273	angiogenesis	angiogenesis	NOUN
d504rj45509	1	274	compared	compare	VERB
d504rj45509	1	275	to	to	ADP
d504rj45509	1	276	all	all	DET
d504rj45509	1	277	other	other	ADJ
d504rj45509	1	278	experimental	experimental	ADJ
d504rj45509	1	279	groups	group	NOUN
d504rj45509	1	280	while	while	SCONJ
d504rj45509	1	281	immobilized	immobilize	VERB
d504rj45509	1	282	bmp-2	bmp-2	SYM
d504rj45509	1	283	promoted	promote	VERB
d504rj45509	1	284	osteoid	osteoid	NOUN
d504rj45509	1	285	deposition	deposition	NOUN
d504rj45509	1	286	.	.	PUNCT