id sid tid token lemma pos d504rj45311 1 1 this this DET d504rj45311 1 2 dissertation dissertation NOUN d504rj45311 1 3 details detail VERB d504rj45311 1 4 the the DET d504rj45311 1 5 synthetic synthetic ADJ d504rj45311 1 6 efforts effort NOUN d504rj45311 1 7 that that PRON d504rj45311 1 8 ultimately ultimately ADV d504rj45311 1 9 culminated culminate VERB d504rj45311 1 10 in in ADP d504rj45311 1 11 the the DET d504rj45311 1 12 first first ADJ d504rj45311 1 13 successful successful ADJ d504rj45311 1 14 total total ADJ d504rj45311 1 15 synthesis synthesis NOUN d504rj45311 1 16 of of ADP d504rj45311 1 17 the the DET d504rj45311 1 18 cytotoxic cytotoxic ADJ d504rj45311 1 19 marine marine ADJ d504rj45311 1 20 natural natural ADJ d504rj45311 1 21 products product NOUN d504rj45311 1 22 myriaporones myriaporone NOUN d504rj45311 1 23 1 1 NUM d504rj45311 1 24 , , PUNCT d504rj45311 1 25 3 3 NUM d504rj45311 1 26 , , PUNCT d504rj45311 1 27 and and CCONJ d504rj45311 1 28 4 4 X d504rj45311 1 29 . . PUNCT d504rj45311 2 1 our our PRON d504rj45311 2 2 interest interest NOUN d504rj45311 2 3 in in ADP d504rj45311 2 4 these these DET d504rj45311 2 5 molecules molecule NOUN d504rj45311 2 6 stemmed stem VERB d504rj45311 2 7 from from ADP d504rj45311 2 8 their their PRON d504rj45311 2 9 demonstrated demonstrate VERB d504rj45311 2 10 antitumor antitumor NOUN d504rj45311 2 11 activity activity NOUN d504rj45311 2 12 , , PUNCT d504rj45311 2 13 as as ADV d504rj45311 2 14 well well ADV d504rj45311 2 15 as as ADP d504rj45311 2 16 their their PRON d504rj45311 2 17 structural structural ADJ d504rj45311 2 18 similarity similarity NOUN d504rj45311 2 19 to to ADP d504rj45311 2 20 a a DET d504rj45311 2 21 highly highly ADV d504rj45311 2 22 potent potent ADJ d504rj45311 2 23 class class NOUN d504rj45311 2 24 of of ADP d504rj45311 2 25 natural natural ADJ d504rj45311 2 26 products product NOUN d504rj45311 2 27 , , PUNCT d504rj45311 2 28 the the DET d504rj45311 2 29 tedanolides tedanolide NOUN d504rj45311 2 30 . . PUNCT d504rj45311 3 1 although although SCONJ d504rj45311 3 2 a a DET d504rj45311 3 3 number number NOUN d504rj45311 3 4 of of ADP d504rj45311 3 5 groups group NOUN d504rj45311 3 6 have have AUX d504rj45311 3 7 embarked embark VERB d504rj45311 3 8 on on ADP d504rj45311 3 9 the the DET d504rj45311 3 10 total total ADJ d504rj45311 3 11 synthesis synthesis NOUN d504rj45311 3 12 of of ADP d504rj45311 3 13 tedanolide tedanolide NOUN d504rj45311 3 14 over over ADP d504rj45311 3 15 the the DET d504rj45311 3 16 years year NOUN d504rj45311 3 17 , , PUNCT d504rj45311 3 18 its its PRON d504rj45311 3 19 complex complex ADJ d504rj45311 3 20 architecture architecture NOUN d504rj45311 3 21 has have AUX d504rj45311 3 22 prevented prevent VERB d504rj45311 3 23 its its PRON d504rj45311 3 24 completion completion NOUN d504rj45311 3 25 and and CCONJ d504rj45311 3 26 only only ADV d504rj45311 3 27 one one NUM d504rj45311 3 28 group group NOUN d504rj45311 3 29 has have AUX d504rj45311 3 30 successfully successfully ADV d504rj45311 3 31 completed complete VERB d504rj45311 3 32 13 13 NUM d504rj45311 3 33 - - PUNCT d504rj45311 3 34 deoxytedanolide deoxytedanolide NOUN d504rj45311 3 35 . . PUNCT d504rj45311 4 1 therefore therefore ADV d504rj45311 4 2 , , PUNCT d504rj45311 4 3 our our PRON d504rj45311 4 4 ultimate ultimate ADJ d504rj45311 4 5 goal goal NOUN d504rj45311 4 6 is be AUX d504rj45311 4 7 to to PART d504rj45311 4 8 determine determine VERB d504rj45311 4 9 whether whether SCONJ d504rj45311 4 10 the the DET d504rj45311 4 11 myriaporones myriaporone NOUN d504rj45311 4 12 and and CCONJ d504rj45311 4 13 tedanolides tedanolide NOUN d504rj45311 4 14 share share VERB d504rj45311 4 15 an an DET d504rj45311 4 16 identical identical ADJ d504rj45311 4 17 biological biological ADJ d504rj45311 4 18 receptor receptor NOUN d504rj45311 4 19 and and CCONJ d504rj45311 4 20 have have VERB d504rj45311 4 21 similar similar ADJ d504rj45311 4 22 modes mode NOUN d504rj45311 4 23 of of ADP d504rj45311 4 24 action action NOUN d504rj45311 4 25 and and CCONJ d504rj45311 4 26 , , PUNCT d504rj45311 4 27 if if SCONJ d504rj45311 4 28 so so ADV d504rj45311 4 29 , , PUNCT d504rj45311 4 30 then then ADV d504rj45311 4 31 the the DET d504rj45311 4 32 myriaporones myriaporone NOUN d504rj45311 4 33 would would AUX d504rj45311 4 34 represent represent VERB d504rj45311 4 35 structurally structurally ADV d504rj45311 4 36 simplified simplify VERB d504rj45311 4 37 tedanolide tedanolide NOUN d504rj45311 4 38 analogues analogue NOUN d504rj45311 4 39 . . PUNCT d504rj45311 5 1 at at ADP d504rj45311 5 2 the the DET d504rj45311 5 3 time time NOUN d504rj45311 5 4 of of ADP d504rj45311 5 5 isolation isolation NOUN d504rj45311 5 6 , , PUNCT d504rj45311 5 7 the the DET d504rj45311 5 8 stereochemistry stereochemistry NOUN d504rj45311 5 9 of of ADP d504rj45311 5 10 two two NUM d504rj45311 5 11 centers center NOUN d504rj45311 5 12 in in ADP d504rj45311 5 13 the the DET d504rj45311 5 14 myriaporones myriaporone NOUN d504rj45311 5 15 ( ( PUNCT d504rj45311 5 16 c5 c5 PROPN d504rj45311 5 17 and and CCONJ d504rj45311 5 18 c6 c6 PROPN d504rj45311 5 19 ) ) PUNCT d504rj45311 5 20 was be AUX d504rj45311 5 21 not not PART d504rj45311 5 22 assigned assign VERB d504rj45311 5 23 unambiguously unambiguously ADV d504rj45311 5 24 . . PUNCT d504rj45311 6 1 through through ADP d504rj45311 6 2 completion completion NOUN d504rj45311 6 3 of of ADP d504rj45311 6 4 the the DET d504rj45311 6 5 total total ADJ d504rj45311 6 6 syntheses synthesis NOUN d504rj45311 6 7 and and CCONJ d504rj45311 6 8 nmr nmr NOUN d504rj45311 6 9 comparisons comparison NOUN d504rj45311 6 10 with with ADP d504rj45311 6 11 the the DET d504rj45311 6 12 natural natural ADJ d504rj45311 6 13 products product NOUN d504rj45311 6 14 , , PUNCT d504rj45311 6 15 the the DET d504rj45311 6 16 absolute absolute ADJ d504rj45311 6 17 stereochemistry stereochemistry NOUN d504rj45311 6 18 of of ADP d504rj45311 6 19 this this DET d504rj45311 6 20 class class NOUN d504rj45311 6 21 of of ADP d504rj45311 6 22 natural natural ADJ d504rj45311 6 23 products product NOUN d504rj45311 6 24 has have AUX d504rj45311 6 25 now now ADV d504rj45311 6 26 been be AUX d504rj45311 6 27 determined determine VERB d504rj45311 6 28 . . PUNCT d504rj45311 7 1 in in ADP d504rj45311 7 2 addition addition NOUN d504rj45311 7 3 to to ADP d504rj45311 7 4 completing complete VERB d504rj45311 7 5 the the DET d504rj45311 7 6 myriaporones myriaporone NOUN d504rj45311 7 7 , , PUNCT d504rj45311 7 8 their their PRON d504rj45311 7 9 corresponding corresponding ADJ d504rj45311 7 10 c5 c5 PROPN d504rj45311 7 11 epimers epimer NOUN d504rj45311 7 12 were be AUX d504rj45311 7 13 formed form VERB d504rj45311 7 14 as as ADV d504rj45311 7 15 well well ADV d504rj45311 7 16 and and CCONJ d504rj45311 7 17 all all PRON d504rj45311 7 18 have have AUX d504rj45311 7 19 undergone undergo VERB d504rj45311 7 20 extensive extensive ADJ d504rj45311 7 21 biological biological ADJ d504rj45311 7 22 evaluation evaluation NOUN d504rj45311 7 23 . . PUNCT d504rj45311 8 1 since since SCONJ d504rj45311 8 2 bioavailability bioavailability NOUN d504rj45311 8 3 of of ADP d504rj45311 8 4 these these DET d504rj45311 8 5 natural natural ADJ d504rj45311 8 6 products product NOUN d504rj45311 8 7 is be AUX d504rj45311 8 8 limited limited ADJ d504rj45311 8 9 , , PUNCT d504rj45311 8 10 their their PRON d504rj45311 8 11 activities activity NOUN d504rj45311 8 12 at at ADP d504rj45311 8 13 the the DET d504rj45311 8 14 time time NOUN d504rj45311 8 15 of of ADP d504rj45311 8 16 isolation isolation NOUN d504rj45311 8 17 were be AUX d504rj45311 8 18 reported report VERB d504rj45311 8 19 against against ADP d504rj45311 8 20 only only ADV d504rj45311 8 21 a a DET d504rj45311 8 22 single single ADJ d504rj45311 8 23 cancer cancer NOUN d504rj45311 8 24 cell cell NOUN d504rj45311 8 25 line line NOUN d504rj45311 8 26 . . PUNCT d504rj45311 9 1 the the DET d504rj45311 9 2 highly highly ADV d504rj45311 9 3 efficient efficient ADJ d504rj45311 9 4 synthetic synthetic ADJ d504rj45311 9 5 approach approach NOUN d504rj45311 9 6 discussed discuss VERB d504rj45311 9 7 in in ADP d504rj45311 9 8 this this DET d504rj45311 9 9 dissertation dissertation NOUN d504rj45311 9 10 has have AUX d504rj45311 9 11 allowed allow VERB d504rj45311 9 12 for for ADP d504rj45311 9 13 production production NOUN d504rj45311 9 14 of of ADP d504rj45311 9 15 a a DET d504rj45311 9 16 significant significant ADJ d504rj45311 9 17 quantity quantity NOUN d504rj45311 9 18 of of ADP d504rj45311 9 19 each each DET d504rj45311 9 20 target target NOUN d504rj45311 9 21 molecule molecule NOUN d504rj45311 9 22 and and CCONJ d504rj45311 9 23 corresponding corresponding ADJ d504rj45311 9 24 activities activity NOUN d504rj45311 9 25 against against ADP d504rj45311 9 26 a a DET d504rj45311 9 27 number number NOUN d504rj45311 9 28 of of ADP d504rj45311 9 29 different different ADJ d504rj45311 9 30 cancer cancer NOUN d504rj45311 9 31 cell cell NOUN d504rj45311 9 32 lines line NOUN d504rj45311 9 33 are be AUX d504rj45311 9 34 presented present VERB d504rj45311 9 35 here here ADV d504rj45311 9 36 . . PUNCT d504rj45311 10 1 these these DET d504rj45311 10 2 exciting exciting ADJ d504rj45311 10 3 results result NOUN d504rj45311 10 4 have have AUX d504rj45311 10 5 only only ADV d504rj45311 10 6 strengthened strengthen VERB d504rj45311 10 7 interest interest NOUN d504rj45311 10 8 in in ADP d504rj45311 10 9 the the DET d504rj45311 10 10 myriaporones myriaporone NOUN d504rj45311 10 11 as as ADP d504rj45311 10 12 potential potential ADJ d504rj45311 10 13 drug drug NOUN d504rj45311 10 14 leads lead NOUN d504rj45311 10 15 . . PUNCT d504rj45311 11 1 with with ADP d504rj45311 11 2 the the DET d504rj45311 11 3 total total ADJ d504rj45311 11 4 synthesis synthesis NOUN d504rj45311 11 5 of of ADP d504rj45311 11 6 the the DET d504rj45311 11 7 myriaporones myriaporone NOUN d504rj45311 11 8 complete complete ADJ d504rj45311 11 9 , , PUNCT d504rj45311 11 10 focus focus NOUN d504rj45311 11 11 has have AUX d504rj45311 11 12 switched switch VERB d504rj45311 11 13 to to ADP d504rj45311 11 14 generating generate VERB d504rj45311 11 15 analogues analogue NOUN d504rj45311 11 16 aimed aim VERB d504rj45311 11 17 at at ADP d504rj45311 11 18 uncovering uncover VERB d504rj45311 11 19 structureand structureand NOUN d504rj45311 11 20 conformation conformation NOUN d504rj45311 11 21 - - PUNCT d504rj45311 11 22 activity activity NOUN d504rj45311 11 23 relationships relationship NOUN d504rj45311 11 24 for for ADP d504rj45311 11 25 these these DET d504rj45311 11 26 molecules molecule NOUN d504rj45311 11 27 . . PUNCT d504rj45311 12 1 by by ADP d504rj45311 12 2 forming form VERB d504rj45311 12 3 analogues analogue NOUN d504rj45311 12 4 that that PRON d504rj45311 12 5 are be AUX d504rj45311 12 6 biased bias VERB d504rj45311 12 7 toward toward ADP d504rj45311 12 8 specific specific ADJ d504rj45311 12 9 conformations conformation NOUN d504rj45311 12 10 , , PUNCT d504rj45311 12 11 we we PRON d504rj45311 12 12 hope hope VERB d504rj45311 12 13 to to PART d504rj45311 12 14 maximize maximize VERB d504rj45311 12 15 activity activity NOUN d504rj45311 12 16 and and CCONJ d504rj45311 12 17 learn learn VERB d504rj45311 12 18 more more ADJ d504rj45311 12 19 about about ADP d504rj45311 12 20 the the DET d504rj45311 12 21 relationship relationship NOUN d504rj45311 12 22 between between ADP d504rj45311 12 23 the the DET d504rj45311 12 24 myriaporones myriaporone NOUN d504rj45311 12 25 and and CCONJ d504rj45311 12 26 tedanolides tedanolide NOUN d504rj45311 12 27 . . PUNCT d504rj45311 13 1 current current ADJ d504rj45311 13 2 synthetic synthetic ADJ d504rj45311 13 3 efforts effort NOUN d504rj45311 13 4 toward toward ADP d504rj45311 13 5 a a DET d504rj45311 13 6 number number NOUN d504rj45311 13 7 of of ADP d504rj45311 13 8 analogues analogue NOUN d504rj45311 13 9 will will AUX d504rj45311 13 10 demonstrate demonstrate VERB d504rj45311 13 11 how how SCONJ d504rj45311 13 12 very very ADV d504rj45311 13 13 slight slight ADJ d504rj45311 13 14 modifications modification NOUN d504rj45311 13 15 to to ADP d504rj45311 13 16 our our PRON d504rj45311 13 17 established establish VERB d504rj45311 13 18 route route NOUN d504rj45311 13 19 will will AUX d504rj45311 13 20 lead lead VERB d504rj45311 13 21 to to ADP d504rj45311 13 22 the the DET d504rj45311 13 23 formation formation NOUN d504rj45311 13 24 of of ADP d504rj45311 13 25 a a DET d504rj45311 13 26 diverse diverse ADJ d504rj45311 13 27 array array NOUN d504rj45311 13 28 of of ADP d504rj45311 13 29 new new ADJ d504rj45311 13 30 potential potential ADJ d504rj45311 13 31 chemotherapeutic chemotherapeutic ADJ d504rj45311 13 32 agents agent NOUN d504rj45311 13 33 . . PUNCT