id sid tid token lemma pos cf95j96279s 1 1 bisphosphonates bisphosphonate NOUN cf95j96279s 1 2 are be AUX cf95j96279s 1 3 the the DET cf95j96279s 1 4 most most ADV cf95j96279s 1 5 common common ADJ cf95j96279s 1 6 pharmaceutical pharmaceutical NOUN cf95j96279s 1 7 used use VERB cf95j96279s 1 8 to to PART cf95j96279s 1 9 reduce reduce VERB cf95j96279s 1 10 fracture fracture NOUN cf95j96279s 1 11 risk risk NOUN cf95j96279s 1 12 in in ADP cf95j96279s 1 13 postmenopausal postmenopausal NOUN cf95j96279s 1 14 women woman NOUN cf95j96279s 1 15 suffering suffer VERB cf95j96279s 1 16 from from ADP cf95j96279s 1 17 osteoporosis osteoporosis NOUN cf95j96279s 1 18 , , PUNCT cf95j96279s 1 19 but but CCONJ cf95j96279s 1 20 long long ADJ cf95j96279s 1 21 - - PUNCT cf95j96279s 1 22 term term NOUN cf95j96279s 1 23 bisphosphonate bisphosphonate NOUN cf95j96279s 1 24 treatment treatment NOUN cf95j96279s 1 25 has have AUX cf95j96279s 1 26 been be AUX cf95j96279s 1 27 associated associate VERB cf95j96279s 1 28 with with ADP cf95j96279s 1 29 a a DET cf95j96279s 1 30 rare rare ADJ cf95j96279s 1 31 adverse adverse ADJ cf95j96279s 1 32 effect effect NOUN cf95j96279s 1 33 , , PUNCT cf95j96279s 1 34 atypical atypical ADJ cf95j96279s 1 35 femoral femoral ADJ cf95j96279s 1 36 fractures fracture NOUN cf95j96279s 1 37 ( ( PUNCT cf95j96279s 1 38 affs affs PROPN cf95j96279s 1 39 ) ) PUNCT cf95j96279s 1 40 . . PUNCT cf95j96279s 2 1 there there PRON cf95j96279s 2 2 is be VERB cf95j96279s 2 3 currently currently ADV cf95j96279s 2 4 no no DET cf95j96279s 2 5 suitable suitable ADJ cf95j96279s 2 6 animal animal NOUN cf95j96279s 2 7 model model NOUN cf95j96279s 2 8 to to PART cf95j96279s 2 9 study study VERB cf95j96279s 2 10 the the DET cf95j96279s 2 11 underlying underlying ADJ cf95j96279s 2 12 pathophysiological pathophysiological ADJ cf95j96279s 2 13 mechanisms mechanism NOUN cf95j96279s 2 14 of of ADP cf95j96279s 2 15 affs aff NOUN cf95j96279s 2 16 , , PUNCT cf95j96279s 2 17 which which PRON cf95j96279s 2 18 remain remain VERB cf95j96279s 2 19 unknown unknown ADJ cf95j96279s 2 20 . . PUNCT cf95j96279s 3 1 therefore therefore ADV cf95j96279s 3 2 , , PUNCT cf95j96279s 3 3 the the DET cf95j96279s 3 4 objective objective NOUN cf95j96279s 3 5 of of ADP cf95j96279s 3 6 this this DET cf95j96279s 3 7 project project NOUN cf95j96279s 3 8 was be AUX cf95j96279s 3 9 to to PART cf95j96279s 3 10 investigate investigate VERB cf95j96279s 3 11 a a DET cf95j96279s 3 12 rabbit rabbit NOUN cf95j96279s 3 13 ulnar ulnar NOUN cf95j96279s 3 14 loading loading NOUN cf95j96279s 3 15 model model NOUN cf95j96279s 3 16 for for ADP cf95j96279s 3 17 affs aff NOUN cf95j96279s 3 18 in in ADP cf95j96279s 3 19 cortical cortical ADJ cf95j96279s 3 20 bone bone NOUN cf95j96279s 3 21 during during ADP cf95j96279s 3 22 long long ADJ cf95j96279s 3 23 - - PUNCT cf95j96279s 3 24 term term NOUN cf95j96279s 3 25 bisphosphonate bisphosphonate NOUN cf95j96279s 3 26 treatment treatment NOUN cf95j96279s 3 27 . . PUNCT cf95j96279s 4 1 the the DET cf95j96279s 4 2 fatigue fatigue NOUN cf95j96279s 4 3 life life NOUN cf95j96279s 4 4 and and CCONJ cf95j96279s 4 5 mechanical mechanical ADJ cf95j96279s 4 6 degradation degradation NOUN cf95j96279s 4 7 of of ADP cf95j96279s 4 8 rabbit rabbit NOUN cf95j96279s 4 9 ulnae ulnae NOUN cf95j96279s 4 10 were be AUX cf95j96279s 4 11 measured measure VERB cf95j96279s 4 12 during during ADP cf95j96279s 4 13 ex ex ADJ cf95j96279s 4 14 vivo vivo ADJ cf95j96279s 4 15 loading loading NOUN cf95j96279s 4 16 of of ADP cf95j96279s 4 17 whole whole ADJ cf95j96279s 4 18 forelimbs forelimb NOUN cf95j96279s 4 19 in in ADP cf95j96279s 4 20 order order NOUN cf95j96279s 4 21 to to PART cf95j96279s 4 22 determine determine VERB cf95j96279s 4 23 allowable allowable ADJ cf95j96279s 4 24 limits limit NOUN cf95j96279s 4 25 for for ADP cf95j96279s 4 26 in in ADP cf95j96279s 4 27 vivo vivo ADJ cf95j96279s 4 28 fatigue fatigue NOUN cf95j96279s 4 29 loading loading NOUN cf95j96279s 4 30 regimens regimen NOUN cf95j96279s 4 31 . . PUNCT cf95j96279s 5 1 post post ADJ cf95j96279s 5 2 - - ADJ cf95j96279s 5 3 fatigue fatigue ADJ cf95j96279s 5 4 mechanical mechanical ADJ cf95j96279s 5 5 testing testing NOUN cf95j96279s 5 6 of of ADP cf95j96279s 5 7 whole whole ADJ cf95j96279s 5 8 ulnae ulnae NOUN cf95j96279s 5 9 was be AUX cf95j96279s 5 10 determined determined ADJ cf95j96279s 5 11 to to PART cf95j96279s 5 12 be be AUX cf95j96279s 5 13 impractical impractical ADJ cf95j96279s 5 14 for for ADP cf95j96279s 5 15 use use NOUN cf95j96279s 5 16 in in ADP cf95j96279s 5 17 the the DET cf95j96279s 5 18 model model NOUN cf95j96279s 5 19 due due ADP cf95j96279s 5 20 to to ADP cf95j96279s 5 21 the the DET cf95j96279s 5 22 number number NOUN cf95j96279s 5 23 of of ADP cf95j96279s 5 24 animals animal NOUN cf95j96279s 5 25 required require VERB cf95j96279s 5 26 and and CCONJ cf95j96279s 5 27 low low ADJ cf95j96279s 5 28 sensitivity sensitivity NOUN cf95j96279s 5 29 to to ADP cf95j96279s 5 30 fatigue fatigue NOUN cf95j96279s 5 31 damage damage NOUN cf95j96279s 5 32 . . PUNCT cf95j96279s 6 1 therefore therefore ADV cf95j96279s 6 2 , , PUNCT cf95j96279s 6 3 a a DET cf95j96279s 6 4 novel novel ADJ cf95j96279s 6 5 method method NOUN cf95j96279s 6 6 was be AUX cf95j96279s 6 7 developed develop VERB cf95j96279s 6 8 for for ADP cf95j96279s 6 9 measuring measure VERB cf95j96279s 6 10 the the DET cf95j96279s 6 11 plane plane NOUN cf95j96279s 6 12 strain strain VERB cf95j96279s 6 13 fracture fracture NOUN cf95j96279s 6 14 toughness toughness NOUN cf95j96279s 6 15 of of ADP cf95j96279s 6 16 small small ADJ cf95j96279s 6 17 animal animal NOUN cf95j96279s 6 18 bones bone NOUN cf95j96279s 6 19 at at ADP cf95j96279s 6 20 multiple multiple ADJ cf95j96279s 6 21 locations location NOUN cf95j96279s 6 22 along along ADP cf95j96279s 6 23 the the DET cf95j96279s 6 24 diaphysis diaphysis NOUN cf95j96279s 6 25 using use VERB cf95j96279s 6 26 arc arc NOUN cf95j96279s 6 27 - - PUNCT cf95j96279s 6 28 shaped shape VERB cf95j96279s 6 29 tension tension NOUN cf95j96279s 6 30 specimens specimen NOUN cf95j96279s 6 31 . . PUNCT cf95j96279s 7 1 this this DET cf95j96279s 7 2 test test NOUN cf95j96279s 7 3 method method NOUN cf95j96279s 7 4 was be AUX cf95j96279s 7 5 able able ADJ cf95j96279s 7 6 to to PART cf95j96279s 7 7 produce produce VERB cf95j96279s 7 8 highly highly ADV cf95j96279s 7 9 repeatable repeatable ADJ cf95j96279s 7 10 measurements measurement NOUN cf95j96279s 7 11 in in ADP cf95j96279s 7 12 replicates replicate NOUN cf95j96279s 7 13 ( ( PUNCT cf95j96279s 7 14 coefficient coefficient NOUN cf95j96279s 7 15 of of ADP cf95j96279s 7 16 variation variation NOUN cf95j96279s 7 17 & & CCONJ cf95j96279s 7 18 lt lt PROPN cf95j96279s 7 19 ; ; PUNCT cf95j96279s 7 20 15 15 NUM cf95j96279s 7 21 % % NOUN cf95j96279s 7 22 ) ) PUNCT cf95j96279s 7 23 and and CCONJ cf95j96279s 7 24 detect detect VERB cf95j96279s 7 25 differences difference NOUN cf95j96279s 7 26 in in ADP cf95j96279s 7 27 fracture fracture NOUN cf95j96279s 7 28 toughness toughness NOUN cf95j96279s 7 29 due due ADP cf95j96279s 7 30 to to ADP cf95j96279s 7 31 small small ADJ cf95j96279s 7 32 differences difference NOUN cf95j96279s 7 33 in in ADP cf95j96279s 7 34 tissue tissue NOUN cf95j96279s 7 35 mineral mineral NOUN cf95j96279s 7 36 density density NOUN cf95j96279s 7 37 . . PUNCT cf95j96279s 8 1 finally finally ADV cf95j96279s 8 2 , , PUNCT cf95j96279s 8 3 an an DET cf95j96279s 8 4 in in ADP cf95j96279s 8 5 vivo vivo ADJ cf95j96279s 8 6 rabbit rabbit NOUN cf95j96279s 8 7 ulnar ulnar NOUN cf95j96279s 8 8 loading loading NOUN cf95j96279s 8 9 model model NOUN cf95j96279s 8 10 was be AUX cf95j96279s 8 11 implemented implement VERB cf95j96279s 8 12 to to PART cf95j96279s 8 13 study study VERB cf95j96279s 8 14 affs aff NOUN cf95j96279s 8 15 in in ADP cf95j96279s 8 16 cortical cortical ADJ cf95j96279s 8 17 bone bone NOUN cf95j96279s 8 18 during during ADP cf95j96279s 8 19 long long ADJ cf95j96279s 8 20 - - PUNCT cf95j96279s 8 21 term term NOUN cf95j96279s 8 22 bisphosphonate bisphosphonate NOUN cf95j96279s 8 23 treatment treatment NOUN cf95j96279s 8 24 . . PUNCT cf95j96279s 9 1 several several ADJ cf95j96279s 9 2 low low ADJ cf95j96279s 9 3 body body NOUN cf95j96279s 9 4 mass mass NOUN cf95j96279s 9 5 rabbits rabbit NOUN cf95j96279s 9 6 suffered suffer VERB cf95j96279s 9 7 displaced displace VERB cf95j96279s 9 8 fractures fracture NOUN cf95j96279s 9 9 during during ADP cf95j96279s 9 10 ulnar ulnar NOUN cf95j96279s 9 11 loading loading NOUN cf95j96279s 9 12 and and CCONJ cf95j96279s 9 13 were be AUX cf95j96279s 9 14 thus thus ADV cf95j96279s 9 15 removed remove VERB cf95j96279s 9 16 from from ADP cf95j96279s 9 17 the the DET cf95j96279s 9 18 study study NOUN cf95j96279s 9 19 . . PUNCT cf95j96279s 10 1 treatment treatment NOUN cf95j96279s 10 2 groups group NOUN cf95j96279s 10 3 included include VERB cf95j96279s 10 4 a a DET cf95j96279s 10 5 sham sham NOUN cf95j96279s 10 6 ( ( PUNCT cf95j96279s 10 7 control control NOUN cf95j96279s 10 8 ) ) PUNCT cf95j96279s 10 9 and and CCONJ cf95j96279s 10 10 ovariectomized ovariectomized ADJ cf95j96279s 10 11 rabbits rabbit NOUN cf95j96279s 10 12 which which PRON cf95j96279s 10 13 were be AUX cf95j96279s 10 14 administered administer VERB cf95j96279s 10 15 either either CCONJ cf95j96279s 10 16 vehicle vehicle NOUN cf95j96279s 10 17 ( ( PUNCT cf95j96279s 10 18 saline saline NOUN cf95j96279s 10 19 ) ) PUNCT cf95j96279s 10 20 , , PUNCT cf95j96279s 10 21 a a DET cf95j96279s 10 22 clinical clinical ADJ cf95j96279s 10 23 dose dose NOUN cf95j96279s 10 24 , , PUNCT cf95j96279s 10 25 or or CCONJ cf95j96279s 10 26 a a DET cf95j96279s 10 27 high high ADJ cf95j96279s 10 28 dose dose NOUN cf95j96279s 10 29 of of ADP cf95j96279s 10 30 bisphosphonate bisphosphonate NOUN cf95j96279s 10 31 ( ( PUNCT cf95j96279s 10 32 alendronate alendronate NOUN cf95j96279s 10 33 ) ) PUNCT cf95j96279s 10 34 over over ADP cf95j96279s 10 35 one one NUM cf95j96279s 10 36 year year NOUN cf95j96279s 10 37 . . PUNCT cf95j96279s 11 1 differences difference NOUN cf95j96279s 11 2 in in ADP cf95j96279s 11 3 tissue tissue NOUN cf95j96279s 11 4 mineral mineral NOUN cf95j96279s 11 5 density density NOUN cf95j96279s 11 6 and and CCONJ cf95j96279s 11 7 fracture fracture NOUN cf95j96279s 11 8 toughness toughness NOUN cf95j96279s 11 9 between between ADP cf95j96279s 11 10 treatment treatment NOUN cf95j96279s 11 11 groups group NOUN cf95j96279s 11 12 were be AUX cf95j96279s 11 13 not not PART cf95j96279s 11 14 statistically statistically ADV cf95j96279s 11 15 significant significant ADJ cf95j96279s 11 16 . . PUNCT cf95j96279s 12 1 preliminary preliminary ADJ cf95j96279s 12 2 results result NOUN cf95j96279s 12 3 from from ADP cf95j96279s 12 4 histology histology NOUN cf95j96279s 12 5 indicated indicate VERB cf95j96279s 12 6 that that SCONJ cf95j96279s 12 7 periosteal periosteal ADJ cf95j96279s 12 8 bone bone NOUN cf95j96279s 12 9 formation formation NOUN cf95j96279s 12 10 was be AUX cf95j96279s 12 11 stimulated stimulate VERB cf95j96279s 12 12 in in ADP cf95j96279s 12 13 all all DET cf95j96279s 12 14 treatment treatment NOUN cf95j96279s 12 15 groups group NOUN cf95j96279s 12 16 immediately immediately ADV cf95j96279s 12 17 following follow VERB cf95j96279s 12 18 in in ADP cf95j96279s 12 19 vivo vivo ADJ cf95j96279s 12 20 ulnar ulnar NOUN cf95j96279s 12 21 loading loading NOUN cf95j96279s 12 22 and and CCONJ cf95j96279s 12 23 returned return VERB cf95j96279s 12 24 to to ADP cf95j96279s 12 25 negligible negligible ADJ cf95j96279s 12 26 basal basal ADJ cf95j96279s 12 27 levels level NOUN cf95j96279s 12 28 within within ADP cf95j96279s 12 29 three three NUM cf95j96279s 12 30 months month NOUN cf95j96279s 12 31 , , PUNCT cf95j96279s 12 32 as as SCONJ cf95j96279s 12 33 expected expect VERB cf95j96279s 12 34 . . PUNCT cf95j96279s 13 1 interestingly interestingly ADV cf95j96279s 13 2 , , PUNCT cf95j96279s 13 3 intracortical intracortical ADJ cf95j96279s 13 4 remodeling remodeling NOUN cf95j96279s 13 5 ( ( PUNCT cf95j96279s 13 6 labelled label VERB cf95j96279s 13 7 osteons osteon NOUN cf95j96279s 13 8 ) ) PUNCT cf95j96279s 13 9 was be AUX cf95j96279s 13 10 increased increase VERB cf95j96279s 13 11 immediately immediately ADV cf95j96279s 13 12 following follow VERB cf95j96279s 13 13 in in ADP cf95j96279s 13 14 vivo vivo ADJ cf95j96279s 13 15 ulnar ulnar NOUN cf95j96279s 13 16 loading loading NOUN cf95j96279s 13 17 in in ADP cf95j96279s 13 18 the the DET cf95j96279s 13 19 vehicle vehicle NOUN cf95j96279s 13 20 treatment treatment NOUN cf95j96279s 13 21 group group NOUN cf95j96279s 13 22 and and CCONJ cf95j96279s 13 23 not not PART cf95j96279s 13 24 in in ADP cf95j96279s 13 25 the the DET cf95j96279s 13 26 bisphosphonate bisphosphonate NOUN cf95j96279s 13 27 treatment treatment NOUN cf95j96279s 13 28 groups group NOUN cf95j96279s 13 29 , , PUNCT cf95j96279s 13 30 but but CCONJ cf95j96279s 13 31 further further ADJ cf95j96279s 13 32 analysis analysis NOUN cf95j96279s 13 33 is be AUX cf95j96279s 13 34 needed need VERB cf95j96279s 13 35 . . PUNCT