id sid tid token lemma pos bz60cv45s0f 1 1 malaria malaria NOUN bz60cv45s0f 1 2 remains remain VERB bz60cv45s0f 1 3 the the DET bz60cv45s0f 1 4 most most ADV bz60cv45s0f 1 5 prominent prominent ADJ bz60cv45s0f 1 6 cause cause NOUN bz60cv45s0f 1 7 of of ADP bz60cv45s0f 1 8 child child NOUN bz60cv45s0f 1 9 mortality mortality NOUN bz60cv45s0f 1 10 worldwide worldwide ADV bz60cv45s0f 1 11 . . PUNCT bz60cv45s0f 2 1 infections infection NOUN bz60cv45s0f 2 2 resulting result VERB bz60cv45s0f 2 3 from from ADP bz60cv45s0f 2 4 plasmodium plasmodium NOUN bz60cv45s0f 2 5 falciparum falciparum NOUN bz60cv45s0f 2 6 kill kill VERB bz60cv45s0f 2 7 more more ADJ bz60cv45s0f 2 8 than than ADP bz60cv45s0f 2 9 one one NUM bz60cv45s0f 2 10 million million NUM bz60cv45s0f 2 11 children child NOUN bz60cv45s0f 2 12 in in ADP bz60cv45s0f 2 13 africa africa PROPN bz60cv45s0f 2 14 alone alone ADV bz60cv45s0f 2 15 and and CCONJ bz60cv45s0f 2 16 cause cause VERB bz60cv45s0f 2 17 an an DET bz60cv45s0f 2 18 estimated estimate VERB bz60cv45s0f 2 19 half half ADJ bz60cv45s0f 2 20 - - PUNCT bz60cv45s0f 2 21 billion billion NUM bz60cv45s0f 2 22 episodes episode NOUN bz60cv45s0f 2 23 of of ADP bz60cv45s0f 2 24 disease disease NOUN bz60cv45s0f 2 25 each each DET bz60cv45s0f 2 26 year year NOUN bz60cv45s0f 2 27 . . PUNCT bz60cv45s0f 3 1 the the DET bz60cv45s0f 3 2 current current ADJ bz60cv45s0f 3 3 paradigm paradigm NOUN bz60cv45s0f 3 4 of of ADP bz60cv45s0f 3 5 antimalarial antimalarial ADJ bz60cv45s0f 3 6 drug drug NOUN bz60cv45s0f 3 7 resistance resistance NOUN bz60cv45s0f 3 8 , , PUNCT bz60cv45s0f 3 9 that that SCONJ bz60cv45s0f 3 10 a a DET bz60cv45s0f 3 11 single single ADJ bz60cv45s0f 3 12 gene gene NOUN bz60cv45s0f 3 13 determines determine VERB bz60cv45s0f 3 14 resistance resistance NOUN bz60cv45s0f 3 15 , , PUNCT bz60cv45s0f 3 16 neglects neglect VERB bz60cv45s0f 3 17 the the DET bz60cv45s0f 3 18 complexity complexity NOUN bz60cv45s0f 3 19 with with ADP bz60cv45s0f 3 20 which which PRON bz60cv45s0f 3 21 drug drug NOUN bz60cv45s0f 3 22 resistance resistance NOUN bz60cv45s0f 3 23 evolves evolve VERB bz60cv45s0f 3 24 . . PUNCT bz60cv45s0f 4 1 although although SCONJ bz60cv45s0f 4 2 , , PUNCT bz60cv45s0f 4 3 major major ADJ bz60cv45s0f 4 4 gene gene NOUN bz60cv45s0f 4 5 effects effect NOUN bz60cv45s0f 4 6 such such ADJ bz60cv45s0f 4 7 as as ADP bz60cv45s0f 4 8 the the DET bz60cv45s0f 4 9 chloroquine chloroquine NOUN bz60cv45s0f 4 10 resistance resistance NOUN bz60cv45s0f 4 11 ( ( PUNCT bz60cv45s0f 4 12 cqr cqr NOUN bz60cv45s0f 4 13 ) ) PUNCT bz60cv45s0f 4 14 determinant determinant NOUN bz60cv45s0f 4 15 , , PUNCT bz60cv45s0f 4 16 pfcrt pfcrt NOUN bz60cv45s0f 4 17 , , PUNCT bz60cv45s0f 4 18 have have AUX bz60cv45s0f 4 19 been be AUX bz60cv45s0f 4 20 identified identify VERB bz60cv45s0f 4 21 , , PUNCT bz60cv45s0f 4 22 epidemiological epidemiological ADJ bz60cv45s0f 4 23 studies study NOUN bz60cv45s0f 4 24 identify identify VERB bz60cv45s0f 4 25 a a DET bz60cv45s0f 4 26 range range NOUN bz60cv45s0f 4 27 of of ADP bz60cv45s0f 4 28 drug drug NOUN bz60cv45s0f 4 29 responses response NOUN bz60cv45s0f 4 30 indicative indicative ADJ bz60cv45s0f 4 31 of of ADP bz60cv45s0f 4 32 a a DET bz60cv45s0f 4 33 complex complex ADJ bz60cv45s0f 4 34 trait trait NOUN bz60cv45s0f 4 35 that that PRON bz60cv45s0f 4 36 is be AUX bz60cv45s0f 4 37 impacted impact VERB bz60cv45s0f 4 38 by by ADP bz60cv45s0f 4 39 multiple multiple ADJ bz60cv45s0f 4 40 genes gene NOUN bz60cv45s0f 4 41 . . PUNCT bz60cv45s0f 5 1 understanding understand VERB bz60cv45s0f 5 2 the the DET bz60cv45s0f 5 3 bases basis NOUN bz60cv45s0f 5 4 of of ADP bz60cv45s0f 5 5 these these DET bz60cv45s0f 5 6 traits trait NOUN bz60cv45s0f 5 7 using use VERB bz60cv45s0f 5 8 a a DET bz60cv45s0f 5 9 more more ADV bz60cv45s0f 5 10 robust robust ADJ bz60cv45s0f 5 11 quantitative quantitative ADJ bz60cv45s0f 5 12 approach approach NOUN bz60cv45s0f 5 13 will will AUX bz60cv45s0f 5 14 lead lead VERB bz60cv45s0f 5 15 to to ADP bz60cv45s0f 5 16 the the DET bz60cv45s0f 5 17 identification identification NOUN bz60cv45s0f 5 18 of of ADP bz60cv45s0f 5 19 novel novel ADJ bz60cv45s0f 5 20 genes gene NOUN bz60cv45s0f 5 21 and and CCONJ bz60cv45s0f 5 22 their their PRON bz60cv45s0f 5 23 underlying underlying ADJ bz60cv45s0f 5 24 role role NOUN bz60cv45s0f 5 25 in in ADP bz60cv45s0f 5 26 drug drug NOUN bz60cv45s0f 5 27 resistance resistance NOUN bz60cv45s0f 5 28 . . PUNCT bz60cv45s0f 6 1 in in ADP bz60cv45s0f 6 2 the the DET bz60cv45s0f 6 3 first first ADJ bz60cv45s0f 6 4 study study NOUN bz60cv45s0f 6 5 we we PRON bz60cv45s0f 6 6 re re VERB bz60cv45s0f 6 7 - - VERB bz60cv45s0f 6 8 examined examined ADJ bz60cv45s0f 6 9 response response NOUN bz60cv45s0f 6 10 to to PART bz60cv45s0f 6 11 chloroquine chloroquine VERB bz60cv45s0f 6 12 ( ( PUNCT bz60cv45s0f 6 13 cq cq NOUN bz60cv45s0f 6 14 ) ) PUNCT bz60cv45s0f 6 15 and and CCONJ bz60cv45s0f 6 16 cq cq PROPN bz60cv45s0f 6 17 reversal reversal NOUN bz60cv45s0f 6 18 agents agent NOUN bz60cv45s0f 6 19 in in ADP bz60cv45s0f 6 20 the the DET bz60cv45s0f 6 21 progeny progeny NOUN bz60cv45s0f 6 22 of of ADP bz60cv45s0f 6 23 the the DET bz60cv45s0f 6 24 hb3 hb3 NUM bz60cv45s0f 6 25 and and CCONJ bz60cv45s0f 6 26 dd2 dd2 NOUN bz60cv45s0f 6 27 cross cross PROPN bz60cv45s0f 6 28 . . PUNCT bz60cv45s0f 7 1 quantitative quantitative ADJ bz60cv45s0f 7 2 trait trait NOUN bz60cv45s0f 7 3 loci loci NOUN bz60cv45s0f 7 4 analyses analysis NOUN bz60cv45s0f 7 5 ( ( PUNCT bz60cv45s0f 7 6 qtl qtl PROPN bz60cv45s0f 7 7 ) ) PUNCT bz60cv45s0f 7 8 identify identify VERB bz60cv45s0f 7 9 a a DET bz60cv45s0f 7 10 major major ADJ bz60cv45s0f 7 11 role role NOUN bz60cv45s0f 7 12 of of ADP bz60cv45s0f 7 13 pfcrt pfcrt ADJ bz60cv45s0f 7 14 chloroquine chloroquine NOUN bz60cv45s0f 7 15 resistance resistance NOUN bz60cv45s0f 7 16 , , PUNCT bz60cv45s0f 7 17 but but CCONJ bz60cv45s0f 7 18 additional additional ADJ bz60cv45s0f 7 19 loci locus NOUN bz60cv45s0f 7 20 were be AUX bz60cv45s0f 7 21 found find VERB bz60cv45s0f 7 22 that that SCONJ bz60cv45s0f 7 23 account account NOUN bz60cv45s0f 7 24 for for ADP bz60cv45s0f 7 25 the the DET bz60cv45s0f 7 26 three three NUM bz60cv45s0f 7 27 - - ADJ bz60cv45s0f 7 28 fold fold ADJ bz60cv45s0f 7 29 quantitative quantitative ADJ bz60cv45s0f 7 30 variation variation NOUN bz60cv45s0f 7 31 of of ADP bz60cv45s0f 7 32 response response NOUN bz60cv45s0f 7 33 in in ADP bz60cv45s0f 7 34 cqr cqr PROPN bz60cv45s0f 7 35 progeny progeny PROPN bz60cv45s0f 7 36 . . PUNCT bz60cv45s0f 8 1 we we PRON bz60cv45s0f 8 2 find find VERB bz60cv45s0f 8 3 that that SCONJ bz60cv45s0f 8 4 the the DET bz60cv45s0f 8 5 degree degree NOUN bz60cv45s0f 8 6 of of ADP bz60cv45s0f 8 7 cq cq NOUN bz60cv45s0f 8 8 reversibility reversibility NOUN bz60cv45s0f 8 9 by by ADP bz60cv45s0f 8 10 reversal reversal NOUN bz60cv45s0f 8 11 agents agent NOUN bz60cv45s0f 8 12 is be AUX bz60cv45s0f 8 13 independent independent ADJ bz60cv45s0f 8 14 of of ADP bz60cv45s0f 8 15 cqr cqr NOUN bz60cv45s0f 8 16 response response NOUN bz60cv45s0f 8 17 , , PUNCT bz60cv45s0f 8 18 whereas whereas SCONJ bz60cv45s0f 8 19 reversed reverse VERB bz60cv45s0f 8 20 cq cq ADP bz60cv45s0f 8 21 response response NOUN bz60cv45s0f 8 22 is be AUX bz60cv45s0f 8 23 dependent dependent ADJ bz60cv45s0f 8 24 on on ADP bz60cv45s0f 8 25 levels level NOUN bz60cv45s0f 8 26 of of ADP bz60cv45s0f 8 27 inherent inherent ADJ bz60cv45s0f 8 28 cqr cqr NOUN bz60cv45s0f 8 29 response response NOUN bz60cv45s0f 8 30 . . PUNCT bz60cv45s0f 9 1 the the DET bz60cv45s0f 9 2 identified identify VERB bz60cv45s0f 9 3 additional additional ADJ bz60cv45s0f 9 4 loci locus NOUN bz60cv45s0f 9 5 highlight highlight VERB bz60cv45s0f 9 6 the the DET bz60cv45s0f 9 7 background background NOUN bz60cv45s0f 9 8 complexity complexity NOUN bz60cv45s0f 9 9 to to PART bz60cv45s0f 9 10 provide provide VERB bz60cv45s0f 9 11 clues clue NOUN bz60cv45s0f 9 12 to to ADP bz60cv45s0f 9 13 the the DET bz60cv45s0f 9 14 evolution evolution NOUN bz60cv45s0f 9 15 of of ADP bz60cv45s0f 9 16 cqr cqr NOUN bz60cv45s0f 9 17 and and CCONJ bz60cv45s0f 9 18 to to PART bz60cv45s0f 9 19 facilitate facilitate VERB bz60cv45s0f 9 20 the the DET bz60cv45s0f 9 21 improved improved ADJ bz60cv45s0f 9 22 design design NOUN bz60cv45s0f 9 23 of of ADP bz60cv45s0f 9 24 combination combination NOUN bz60cv45s0f 9 25 therapies therapy NOUN bz60cv45s0f 9 26 that that PRON bz60cv45s0f 9 27 can can AUX bz60cv45s0f 9 28 reverse reverse VERB bz60cv45s0f 9 29 cqr cqr NOUN bz60cv45s0f 9 30 . . PUNCT bz60cv45s0f 10 1 in in ADP bz60cv45s0f 10 2 the the DET bz60cv45s0f 10 3 second second ADJ bz60cv45s0f 10 4 study study NOUN bz60cv45s0f 10 5 , , PUNCT bz60cv45s0f 10 6 we we PRON bz60cv45s0f 10 7 performed perform VERB bz60cv45s0f 10 8 a a DET bz60cv45s0f 10 9 qtl qtl ADJ bz60cv45s0f 10 10 analysis analysis NOUN bz60cv45s0f 10 11 to to PART bz60cv45s0f 10 12 identify identify VERB bz60cv45s0f 10 13 genetic genetic ADJ bz60cv45s0f 10 14 loci locus NOUN bz60cv45s0f 10 15 that that PRON bz60cv45s0f 10 16 account account VERB bz60cv45s0f 10 17 for for ADP bz60cv45s0f 10 18 the the DET bz60cv45s0f 10 19 strongly strongly ADV bz60cv45s0f 10 20 correlated correlated ADJ bz60cv45s0f 10 21 quantitative quantitative ADJ bz60cv45s0f 10 22 sensitivities sensitivity NOUN bz60cv45s0f 10 23 mefloquine mefloquine NOUN bz60cv45s0f 10 24 and and CCONJ bz60cv45s0f 10 25 artemisinin artemisinin ADV bz60cv45s0f 10 26 , , PUNCT bz60cv45s0f 10 27 the the DET bz60cv45s0f 10 28 components component NOUN bz60cv45s0f 10 29 of of ADP bz60cv45s0f 10 30 the the DET bz60cv45s0f 10 31 widely widely ADV bz60cv45s0f 10 32 used use VERB bz60cv45s0f 10 33 combination combination NOUN bz60cv45s0f 10 34 therapy therapy NOUN bz60cv45s0f 10 35 in in ADP bz60cv45s0f 10 36 multi multi ADJ bz60cv45s0f 10 37 - - ADJ bz60cv45s0f 10 38 drug drug ADJ bz60cv45s0f 10 39 resistant resistant ADJ bz60cv45s0f 10 40 ( ( PUNCT bz60cv45s0f 10 41 mdr mdr NOUN bz60cv45s0f 10 42 ) ) PUNCT bz60cv45s0f 10 43 regions region NOUN bz60cv45s0f 10 44 . . PUNCT bz60cv45s0f 11 1 we we PRON bz60cv45s0f 11 2 identified identify VERB bz60cv45s0f 11 3 two two NUM bz60cv45s0f 11 4 qtl qtl NOUN bz60cv45s0f 11 5 that that PRON bz60cv45s0f 11 6 are be AUX bz60cv45s0f 11 7 shared share VERB bz60cv45s0f 11 8 for for ADP bz60cv45s0f 11 9 both both DET bz60cv45s0f 11 10 drug drug NOUN bz60cv45s0f 11 11 responses response NOUN bz60cv45s0f 11 12 that that DET bz60cv45s0f 11 13 point point NOUN bz60cv45s0f 11 14 to to ADP bz60cv45s0f 11 15 genes gene NOUN bz60cv45s0f 11 16 controlling control VERB bz60cv45s0f 11 17 these these DET bz60cv45s0f 11 18 correlated correlated ADJ bz60cv45s0f 11 19 responses response NOUN bz60cv45s0f 11 20 . . PUNCT bz60cv45s0f 12 1 we we PRON bz60cv45s0f 12 2 identified identify VERB bz60cv45s0f 12 3 underlying underlie VERB bz60cv45s0f 12 4 gene gene NOUN bz60cv45s0f 12 5 polymorphisms polymorphism NOUN bz60cv45s0f 12 6 in in ADP bz60cv45s0f 12 7 candidate candidate NOUN bz60cv45s0f 12 8 genes gene NOUN bz60cv45s0f 12 9 at at ADP bz60cv45s0f 12 10 each each DET bz60cv45s0f 12 11 qtl qtl PROPN bz60cv45s0f 12 12 and and CCONJ bz60cv45s0f 12 13 address address VERB bz60cv45s0f 12 14 the the DET bz60cv45s0f 12 15 application application NOUN bz60cv45s0f 12 16 of of ADP bz60cv45s0f 12 17 these these DET bz60cv45s0f 12 18 findings finding NOUN bz60cv45s0f 12 19 in in ADP bz60cv45s0f 12 20 surveillance surveillance NOUN bz60cv45s0f 12 21 and and CCONJ bz60cv45s0f 12 22 anticipation anticipation NOUN bz60cv45s0f 12 23 of of ADP bz60cv45s0f 12 24 imminent imminent ADJ bz60cv45s0f 12 25 drug drug NOUN bz60cv45s0f 12 26 resistance resistance NOUN bz60cv45s0f 12 27 . . PUNCT bz60cv45s0f 13 1 in in ADP bz60cv45s0f 13 2 the the DET bz60cv45s0f 13 3 third third ADJ bz60cv45s0f 13 4 study study NOUN bz60cv45s0f 13 5 , , PUNCT bz60cv45s0f 13 6 we we PRON bz60cv45s0f 13 7 used use VERB bz60cv45s0f 13 8 an an DET bz60cv45s0f 13 9 alternative alternative ADJ bz60cv45s0f 13 10 approach approach NOUN bz60cv45s0f 13 11 to to PART bz60cv45s0f 13 12 identify identify VERB bz60cv45s0f 13 13 the the DET bz60cv45s0f 13 14 gene gene NOUN bz60cv45s0f 13 15 polymorphisms polymorphism NOUN bz60cv45s0f 13 16 underlying underlie VERB bz60cv45s0f 13 17 antimalarial antimalarial ADJ bz60cv45s0f 13 18 drug drug NOUN bz60cv45s0f 13 19 resistance resistance NOUN bz60cv45s0f 13 20 . . PUNCT bz60cv45s0f 14 1 isogenic isogenic ADJ bz60cv45s0f 14 2 parasite parasite NOUN bz60cv45s0f 14 3 lines line NOUN bz60cv45s0f 14 4 were be AUX bz60cv45s0f 14 5 screened screen VERB bz60cv45s0f 14 6 for for ADP bz60cv45s0f 14 7 polymorphisms polymorphism NOUN bz60cv45s0f 14 8 using use VERB bz60cv45s0f 14 9 an an DET bz60cv45s0f 14 10 integrative integrative ADJ bz60cv45s0f 14 11 genomics genomic NOUN bz60cv45s0f 14 12 approach approach NOUN bz60cv45s0f 14 13 . . PUNCT bz60cv45s0f 15 1 comparative comparative ADJ bz60cv45s0f 15 2 genome genome NOUN bz60cv45s0f 15 3 hybridizations hybridization NOUN bz60cv45s0f 15 4 and and CCONJ bz60cv45s0f 15 5 expression expression NOUN bz60cv45s0f 15 6 arrays array NOUN bz60cv45s0f 15 7 identified identify VERB bz60cv45s0f 15 8 co co ADJ bz60cv45s0f 15 9 - - ADJ bz60cv45s0f 15 10 adapted adapt VERB bz60cv45s0f 15 11 gene gene NOUN bz60cv45s0f 15 12 complexes complex NOUN bz60cv45s0f 15 13 associated associate VERB bz60cv45s0f 15 14 with with ADP bz60cv45s0f 15 15 in in ADP bz60cv45s0f 15 16 vitro vitro X bz60cv45s0f 15 17 laboratory laboratory NOUN bz60cv45s0f 15 18 selections selection NOUN bz60cv45s0f 15 19 by by ADP bz60cv45s0f 15 20 cq cq PROPN bz60cv45s0f 15 21 and and CCONJ bz60cv45s0f 15 22 quinine quinine NOUN bz60cv45s0f 15 23 . . PUNCT bz60cv45s0f 16 1 we we PRON bz60cv45s0f 16 2 demonstrate demonstrate VERB bz60cv45s0f 16 3 the the DET bz60cv45s0f 16 4 feasibility feasibility NOUN bz60cv45s0f 16 5 and and CCONJ bz60cv45s0f 16 6 utility utility NOUN bz60cv45s0f 16 7 of of ADP bz60cv45s0f 16 8 this this DET bz60cv45s0f 16 9 approach approach NOUN bz60cv45s0f 16 10 to to PART bz60cv45s0f 16 11 identify identify VERB bz60cv45s0f 16 12 structural structural ADJ bz60cv45s0f 16 13 and and CCONJ bz60cv45s0f 16 14 transcriptional transcriptional NOUN bz60cv45s0f 16 15 gene gene NOUN bz60cv45s0f 16 16 polymorphisms polymorphism NOUN bz60cv45s0f 16 17 that that PRON bz60cv45s0f 16 18 will will AUX bz60cv45s0f 16 19 provide provide VERB bz60cv45s0f 16 20 insights insight NOUN bz60cv45s0f 16 21 to to ADP bz60cv45s0f 16 22 unresolved unresolved ADJ bz60cv45s0f 16 23 questions question NOUN bz60cv45s0f 16 24 of of ADP bz60cv45s0f 16 25 drug drug NOUN bz60cv45s0f 16 26 resistance resistance NOUN bz60cv45s0f 16 27 evolution evolution NOUN bz60cv45s0f 16 28 . . PUNCT