id sid tid token lemma pos bg257d29c81 1 1 mycobacterium mycobacterium PROPN bg257d29c81 1 2 tuberculosis tuberculosis NOUN bg257d29c81 1 3 , , PUNCT bg257d29c81 1 4 the the DET bg257d29c81 1 5 causative causative ADJ bg257d29c81 1 6 agent agent NOUN bg257d29c81 1 7 of of ADP bg257d29c81 1 8 tuberculosis tuberculosis NOUN bg257d29c81 1 9 ( ( PUNCT bg257d29c81 1 10 tb tb PROPN bg257d29c81 1 11 ) ) PUNCT bg257d29c81 1 12 , , PUNCT bg257d29c81 1 13 is be AUX bg257d29c81 1 14 responsible responsible ADJ bg257d29c81 1 15 for for ADP bg257d29c81 1 16 nearly nearly ADV bg257d29c81 1 17 2 2 NUM bg257d29c81 1 18 million million NUM bg257d29c81 1 19 deaths death NOUN bg257d29c81 1 20 each each DET bg257d29c81 1 21 year year NOUN bg257d29c81 1 22 . . PUNCT bg257d29c81 2 1 the the DET bg257d29c81 2 2 rise rise NOUN bg257d29c81 2 3 in in ADP bg257d29c81 2 4 hiv hiv PROPN bg257d29c81 2 5 co co NOUN bg257d29c81 2 6 - - NOUN bg257d29c81 2 7 infections infection NOUN bg257d29c81 2 8 and and CCONJ bg257d29c81 2 9 the the DET bg257d29c81 2 10 neglect neglect NOUN bg257d29c81 2 11 of of ADP bg257d29c81 2 12 tb tb PROPN bg257d29c81 2 13 control control NOUN bg257d29c81 2 14 programs program NOUN bg257d29c81 2 15 has have AUX bg257d29c81 2 16 led lead VERB bg257d29c81 2 17 to to ADP bg257d29c81 2 18 tb tb PROPN bg257d29c81 2 19 's 's PART bg257d29c81 2 20 re re NOUN bg257d29c81 2 21 - - NOUN bg257d29c81 2 22 emergence emergence NOUN bg257d29c81 2 23 as as ADP bg257d29c81 2 24 a a DET bg257d29c81 2 25 serious serious ADJ bg257d29c81 2 26 public public ADJ bg257d29c81 2 27 health health NOUN bg257d29c81 2 28 concern concern NOUN bg257d29c81 2 29 . . PUNCT bg257d29c81 3 1 an an DET bg257d29c81 3 2 improved improved ADJ bg257d29c81 3 3 understanding understanding NOUN bg257d29c81 3 4 of of ADP bg257d29c81 3 5 host host NOUN bg257d29c81 3 6 immune immune ADJ bg257d29c81 3 7 responses response NOUN bg257d29c81 3 8 following follow VERB bg257d29c81 3 9 mycobacterium mycobacterium NOUN bg257d29c81 3 10 infection infection NOUN bg257d29c81 3 11 can can AUX bg257d29c81 3 12 provide provide VERB bg257d29c81 3 13 insights insight NOUN bg257d29c81 3 14 into into ADP bg257d29c81 3 15 the the DET bg257d29c81 3 16 pathogenesis pathogenesis NOUN bg257d29c81 3 17 of of ADP bg257d29c81 3 18 virulent virulent ADJ bg257d29c81 3 19 mycobacteria mycobacteria NOUN bg257d29c81 3 20 and and CCONJ bg257d29c81 3 21 identify identify VERB bg257d29c81 3 22 potential potential ADJ bg257d29c81 3 23 targets target NOUN bg257d29c81 3 24 for for ADP bg257d29c81 3 25 rational rational ADJ bg257d29c81 3 26 anti anti ADJ bg257d29c81 3 27 - - ADJ bg257d29c81 3 28 tb tb ADJ bg257d29c81 3 29 drug drug NOUN bg257d29c81 3 30 design design NOUN bg257d29c81 3 31 . . PUNCT bg257d29c81 4 1 our our PRON bg257d29c81 4 2 work work NOUN bg257d29c81 4 3 indicates indicate VERB bg257d29c81 4 4 that that SCONJ bg257d29c81 4 5 infection infection NOUN bg257d29c81 4 6 with with ADP bg257d29c81 4 7 isogenic isogenic ADJ bg257d29c81 4 8 strains strain NOUN bg257d29c81 4 9 of of ADP bg257d29c81 4 10 m. m. NOUN bg257d29c81 4 11 tuberculosis tuberculosis NOUN bg257d29c81 4 12 results result NOUN bg257d29c81 4 13 in in ADP bg257d29c81 4 14 differential differential ADJ bg257d29c81 4 15 activation activation NOUN bg257d29c81 4 16 of of ADP bg257d29c81 4 17 various various ADJ bg257d29c81 4 18 transcription transcription NOUN bg257d29c81 4 19 factors factor NOUN bg257d29c81 4 20 . . PUNCT bg257d29c81 5 1 previous previous ADJ bg257d29c81 5 2 studies study NOUN bg257d29c81 5 3 have have AUX bg257d29c81 5 4 demonstrated demonstrate VERB bg257d29c81 5 5 that that SCONJ bg257d29c81 5 6 expression expression NOUN bg257d29c81 5 7 of of ADP bg257d29c81 5 8 the the DET bg257d29c81 5 9 folate folate NOUN bg257d29c81 5 10 receptor receptor NOUN bg257d29c81 5 11 ( ( PUNCT bg257d29c81 5 12 fr fr PROPN bg257d29c81 5 13 ) ) PUNCT bg257d29c81 5 14 is be AUX bg257d29c81 5 15 primarily primarily ADV bg257d29c81 5 16 restricted restrict VERB bg257d29c81 5 17 to to ADP bg257d29c81 5 18 tumor tumor NOUN bg257d29c81 5 19 cells cell NOUN bg257d29c81 5 20 and and CCONJ bg257d29c81 5 21 activated activate VERB bg257d29c81 5 22 macrophages macrophage NOUN bg257d29c81 5 23 . . PUNCT bg257d29c81 6 1 we we PRON bg257d29c81 6 2 hypothesize hypothesize VERB bg257d29c81 6 3 that that SCONJ bg257d29c81 6 4 the the DET bg257d29c81 6 5 fr fr PROPN bg257d29c81 6 6 may may AUX bg257d29c81 6 7 also also ADV bg257d29c81 6 8 be be AUX bg257d29c81 6 9 expressed express VERB bg257d29c81 6 10 on on ADP bg257d29c81 6 11 activated activate VERB bg257d29c81 6 12 , , PUNCT bg257d29c81 6 13 tuberculosis tuberculosis NOUN bg257d29c81 6 14 - - PUNCT bg257d29c81 6 15 infected infect VERB bg257d29c81 6 16 macrophages macrophage NOUN bg257d29c81 6 17 . . PUNCT bg257d29c81 7 1 addressing address VERB bg257d29c81 7 2 the the DET bg257d29c81 7 3 biology biology NOUN bg257d29c81 7 4 behind behind ADP bg257d29c81 7 5 fr fr PROPN bg257d29c81 7 6 expression expression NOUN bg257d29c81 7 7 in in ADP bg257d29c81 7 8 mycobacterium mycobacterium NOUN bg257d29c81 7 9 - - PUNCT bg257d29c81 7 10 infected infect VERB bg257d29c81 7 11 mouse mouse NOUN bg257d29c81 7 12 and and CCONJ bg257d29c81 7 13 human human ADJ bg257d29c81 7 14 macrophages macrophage NOUN bg257d29c81 7 15 may may AUX bg257d29c81 7 16 lead lead VERB bg257d29c81 7 17 to to ADP bg257d29c81 7 18 new new ADJ bg257d29c81 7 19 mechanisms mechanism NOUN bg257d29c81 7 20 to to PART bg257d29c81 7 21 treat treat VERB bg257d29c81 7 22 drug drug NOUN bg257d29c81 7 23 - - PUNCT bg257d29c81 7 24 sensitive sensitive ADJ bg257d29c81 7 25 and and CCONJ bg257d29c81 7 26 drug drug NOUN bg257d29c81 7 27 - - PUNCT bg257d29c81 7 28 resistant resistant ADJ bg257d29c81 7 29 tuberculosis tuberculosis NOUN bg257d29c81 7 30 . . PUNCT