id sid tid token lemma pos bc386h4739k 1 1 maldi maldi PROPN bc386h4739k 1 2 - - PUNCT bc386h4739k 1 3 tof tof PROPN bc386h4739k 1 4 imaging imaging NOUN bc386h4739k 1 5 mass mass NOUN bc386h4739k 1 6 spectrometry spectrometry NOUN bc386h4739k 1 7 ( ( PUNCT bc386h4739k 1 8 ims ims PROPN bc386h4739k 1 9 ) ) PUNCT bc386h4739k 1 10 is be AUX bc386h4739k 1 11 a a DET bc386h4739k 1 12 common common ADJ bc386h4739k 1 13 technique technique NOUN bc386h4739k 1 14 used use VERB bc386h4739k 1 15 for for ADP bc386h4739k 1 16 analyzing analyze VERB bc386h4739k 1 17 tissue tissue NOUN bc386h4739k 1 18 samples sample NOUN bc386h4739k 1 19 , , PUNCT bc386h4739k 1 20 as as SCONJ bc386h4739k 1 21 it it PRON bc386h4739k 1 22 allows allow VERB bc386h4739k 1 23 the the DET bc386h4739k 1 24 user user NOUN bc386h4739k 1 25 to to PART bc386h4739k 1 26 detect detect VERB bc386h4739k 1 27 multiple multiple ADJ bc386h4739k 1 28 different different ADJ bc386h4739k 1 29 analytes analyte NOUN bc386h4739k 1 30 simultaneously.however simultaneously.however PROPN bc386h4739k 1 31 , , PUNCT bc386h4739k 1 32 the the DET bc386h4739k 1 33 detection detection NOUN bc386h4739k 1 34 and and CCONJ bc386h4739k 1 35 analysis analysis NOUN bc386h4739k 1 36 of of ADP bc386h4739k 1 37 these these DET bc386h4739k 1 38 analytes analyte NOUN bc386h4739k 1 39 may may AUX bc386h4739k 1 40 sometimes sometimes ADV bc386h4739k 1 41 be be AUX bc386h4739k 1 42 hampered hamper VERB bc386h4739k 1 43 due due ADP bc386h4739k 1 44 to to ADP bc386h4739k 1 45 the the DET bc386h4739k 1 46 presence presence NOUN bc386h4739k 1 47 of of ADP bc386h4739k 1 48 contaminants contaminant NOUN bc386h4739k 1 49 in in ADP bc386h4739k 1 50 the the DET bc386h4739k 1 51 tissue tissue NOUN bc386h4739k 1 52 microenvironment microenvironment NOUN bc386h4739k 1 53 , , PUNCT bc386h4739k 1 54 which which PRON bc386h4739k 1 55 leads lead VERB bc386h4739k 1 56 to to ADP bc386h4739k 1 57 ion ion NOUN bc386h4739k 1 58 suppression.this suppression.this NOUN bc386h4739k 1 59 challenge challenge NOUN bc386h4739k 1 60 necessitates necessitate VERB bc386h4739k 1 61 t­­­he t­­­he NOUN bc386h4739k 1 62 development development NOUN bc386h4739k 1 63 of of ADP bc386h4739k 1 64 an an DET bc386h4739k 1 65 active active ADJ bc386h4739k 1 66 extraction extraction NOUN bc386h4739k 1 67 technique technique NOUN bc386h4739k 1 68 to to PART bc386h4739k 1 69 selectively selectively ADV bc386h4739k 1 70 isolate isolate VERB bc386h4739k 1 71 analytes analyte NOUN bc386h4739k 1 72 of of ADP bc386h4739k 1 73 interest interest NOUN bc386h4739k 1 74 without without ADP bc386h4739k 1 75 compromising compromise VERB bc386h4739k 1 76 their their PRON bc386h4739k 1 77 spatial spatial ADJ bc386h4739k 1 78 localization localization NOUN bc386h4739k 1 79 within within ADP bc386h4739k 1 80 a a DET bc386h4739k 1 81 tissue tissue NOUN bc386h4739k 1 82 sample.this sample.this DET bc386h4739k 1 83 study study NOUN bc386h4739k 1 84 proposes propose VERB bc386h4739k 1 85 a a DET bc386h4739k 1 86 magnetic magnetic ADJ bc386h4739k 1 87 bead bead NOUN bc386h4739k 1 88 - - PUNCT bc386h4739k 1 89 based base VERB bc386h4739k 1 90 active active ADJ bc386h4739k 1 91 extraction extraction NOUN bc386h4739k 1 92 approach approach NOUN bc386h4739k 1 93 to to PART bc386h4739k 1 94 selectively selectively ADV bc386h4739k 1 95 sequester sequester VERB bc386h4739k 1 96 peptides peptide NOUN bc386h4739k 1 97 of of ADP bc386h4739k 1 98 interest interest NOUN bc386h4739k 1 99 from from ADP bc386h4739k 1 100 tissue tissue NOUN bc386h4739k 1 101 samples.the samples.the DET bc386h4739k 1 102 technique technique NOUN bc386h4739k 1 103 utilizes utilize VERB bc386h4739k 1 104 a a DET bc386h4739k 1 105 heterobifunctional heterobifunctional ADJ bc386h4739k 1 106 cross cross NOUN bc386h4739k 1 107 - - NOUN bc386h4739k 1 108 linker linker ADJ bc386h4739k 1 109 to to PART bc386h4739k 1 110 covalently covalently ADV bc386h4739k 1 111 bind bind VERB bc386h4739k 1 112 peptides peptide NOUN bc386h4739k 1 113 with with ADP bc386h4739k 1 114 free free ADJ bc386h4739k 1 115 primary primary ADJ bc386h4739k 1 116 amine amine ADJ bc386h4739k 1 117 groups group NOUN bc386h4739k 1 118 to to PART bc386h4739k 1 119 functionalized functionalize VERB bc386h4739k 1 120 magnetic magnetic ADJ bc386h4739k 1 121 beads bead NOUN bc386h4739k 1 122 . . PUNCT bc386h4739k 2 1 the the DET bc386h4739k 2 2 cross cross ADJ bc386h4739k 2 3 - - ADJ bc386h4739k 2 4 linked link VERB bc386h4739k 2 5 peptides peptide NOUN bc386h4739k 2 6 can can AUX bc386h4739k 2 7 then then ADV bc386h4739k 2 8 be be AUX bc386h4739k 2 9 collected collect VERB bc386h4739k 2 10 using use VERB bc386h4739k 2 11 a a DET bc386h4739k 2 12 transfer transfer NOUN bc386h4739k 2 13 magnet magnet NOUN bc386h4739k 2 14 and and CCONJ bc386h4739k 2 15 imaged image VERB bc386h4739k 2 16 using use VERB bc386h4739k 2 17 maldi maldi PROPN bc386h4739k 2 18 - - PUNCT bc386h4739k 2 19 tof tof PROPN bc386h4739k 2 20 ims.we ims.we NOUN bc386h4739k 2 21 have have AUX bc386h4739k 2 22 established establish VERB bc386h4739k 2 23 that that SCONJ bc386h4739k 2 24 this this DET bc386h4739k 2 25 technique technique NOUN bc386h4739k 2 26 not not PART bc386h4739k 2 27 only only ADV bc386h4739k 2 28 successfully successfully ADV bc386h4739k 2 29 isolates isolate VERB bc386h4739k 2 30 peptides peptide NOUN bc386h4739k 2 31 both both CCONJ bc386h4739k 2 32 in in ADP bc386h4739k 2 33 - - PUNCT bc386h4739k 2 34 solution solution NOUN bc386h4739k 2 35 and and CCONJ bc386h4739k 2 36 on on ADP bc386h4739k 2 37 a a DET bc386h4739k 2 38 solid solid ADJ bc386h4739k 2 39 surface surface NOUN bc386h4739k 2 40 , , PUNCT bc386h4739k 2 41 but but CCONJ bc386h4739k 2 42 also also ADV bc386h4739k 2 43 extracts extract VERB bc386h4739k 2 44 peptides peptide NOUN bc386h4739k 2 45 from from ADP bc386h4739k 2 46 a a DET bc386h4739k 2 47 tissue tissue NOUN bc386h4739k 2 48 section section NOUN bc386h4739k 2 49 without without ADP bc386h4739k 2 50 significantly significantly ADV bc386h4739k 2 51 compromising compromise VERB bc386h4739k 2 52 their their PRON bc386h4739k 2 53 spatial spatial ADJ bc386h4739k 2 54 localization.this localization.this DET bc386h4739k 2 55 novel novel NOUN bc386h4739k 2 56 method method NOUN bc386h4739k 2 57 provides provide VERB bc386h4739k 2 58 the the DET bc386h4739k 2 59 means mean NOUN bc386h4739k 2 60 to to PART bc386h4739k 2 61 detect detect VERB bc386h4739k 2 62 a a DET bc386h4739k 2 63 unique unique ADJ bc386h4739k 2 64 subset subset NOUN bc386h4739k 2 65 of of ADP bc386h4739k 2 66 peptides peptide NOUN bc386h4739k 2 67 from from ADP bc386h4739k 2 68 tissue tissue NOUN bc386h4739k 2 69 sections section NOUN bc386h4739k 2 70 when when SCONJ bc386h4739k 2 71 compared compare VERB bc386h4739k 2 72 to to ADP bc386h4739k 2 73 unextracted unextracted ADJ bc386h4739k 2 74 tryptically tryptically PROPN bc386h4739k 2 75 digested digest VERB bc386h4739k 2 76 tissue tissue NOUN bc386h4739k 2 77 , , PUNCT bc386h4739k 2 78 all all PRON bc386h4739k 2 79 while while SCONJ bc386h4739k 2 80 minimizing minimize VERB bc386h4739k 2 81 the the DET bc386h4739k 2 82 presence presence NOUN bc386h4739k 2 83 of of ADP bc386h4739k 2 84 contaminants contaminant NOUN bc386h4739k 2 85 and and CCONJ bc386h4739k 2 86 maintaining maintain VERB bc386h4739k 2 87 spatial spatial ADJ bc386h4739k 2 88 localization localization NOUN bc386h4739k 2 89 . . PUNCT