id	sid	tid	token	lemma	pos
9z902z1424n	1	1	quantifying	quantify	VERB
9z902z1424n	1	2	the	the	DET
9z902z1424n	1	3	spatial	spatial	ADJ
9z902z1424n	1	4	relationship	relationship	NOUN
9z902z1424n	1	5	between	between	ADP
9z902z1424n	1	6	mechanical	mechanical	ADJ
9z902z1424n	1	7	deformation	deformation	NOUN
9z902z1424n	1	8	and	and	CCONJ
9z902z1424n	1	9	signaling	signal	VERB
9z902z1424n	1	10	protein	protein	NOUN
9z902z1424n	1	11	expression	expression	NOUN
9z902z1424n	1	12	within	within	ADP
9z902z1424n	1	13	trabecular	trabecular	ADJ
9z902z1424n	1	14	bone	bone	NOUN
9z902z1424n	1	15	is	be	AUX
9z902z1424n	1	16	essential	essential	ADJ
9z902z1424n	1	17	to	to	ADP
9z902z1424n	1	18	understanding	understand	VERB
9z902z1424n	1	19	the	the	DET
9z902z1424n	1	20	mechanobiological	mechanobiological	ADJ
9z902z1424n	1	21	signaling	signal	VERB
9z902z1424n	1	22	cascade	cascade	NOUN
9z902z1424n	1	23	that	that	PRON
9z902z1424n	1	24	maintains	maintain	VERB
9z902z1424n	1	25	bone	bone	NOUN
9z902z1424n	1	26	health	health	NOUN
9z902z1424n	1	27	.	.	PUNCT
9z902z1424n	2	1	interventions	intervention	NOUN
9z902z1424n	2	2	such	such	ADJ
9z902z1424n	2	3	as	as	ADP
9z902z1424n	2	4	pharmaceuticals	pharmaceutical	NOUN
9z902z1424n	2	5	that	that	PRON
9z902z1424n	2	6	can	can	AUX
9z902z1424n	2	7	leverage	leverage	VERB
9z902z1424n	2	8	the	the	DET
9z902z1424n	2	9	mechanobiological	mechanobiological	ADJ
9z902z1424n	2	10	signaling	signal	VERB
9z902z1424n	2	11	processes	process	NOUN
9z902z1424n	2	12	in	in	ADP
9z902z1424n	2	13	trabecular	trabecular	ADJ
9z902z1424n	2	14	bone	bone	NOUN
9z902z1424n	2	15	can	can	AUX
9z902z1424n	2	16	provide	provide	VERB
9z902z1424n	2	17	new	new	ADJ
9z902z1424n	2	18	therapeutic	therapeutic	ADJ
9z902z1424n	2	19	approaches	approach	NOUN
9z902z1424n	2	20	for	for	ADP
9z902z1424n	2	21	bone	bone	NOUN
9z902z1424n	2	22	repair	repair	NOUN
9z902z1424n	2	23	for	for	ADP
9z902z1424n	2	24	bone	bone	NOUN
9z902z1424n	2	25	diseases	disease	NOUN
9z902z1424n	2	26	,	,	PUNCT
9z902z1424n	2	27	such	such	ADJ
9z902z1424n	2	28	as	as	ADP
9z902z1424n	2	29	osteoporosis	osteoporosis	NOUN
9z902z1424n	2	30	.	.	PUNCT
9z902z1424n	3	1	there	there	PRON
9z902z1424n	3	2	were	be	VERB
9z902z1424n	3	3	2	2	NUM
9z902z1424n	3	4	million	million	NUM
9z902z1424n	3	5	cases	case	NOUN
9z902z1424n	3	6	of	of	ADP
9z902z1424n	3	7	osteoporotic	osteoporotic	ADJ
9z902z1424n	3	8	fracture	fracture	NOUN
9z902z1424n	3	9	in	in	ADP
9z902z1424n	3	10	2005	2005	NUM
9z902z1424n	3	11	,	,	PUNCT
9z902z1424n	3	12	with	with	ADP
9z902z1424n	3	13	a	a	DET
9z902z1424n	3	14	treatment	treatment	NOUN
9z902z1424n	3	15	cost	cost	NOUN
9z902z1424n	3	16	of	of	ADP
9z902z1424n	3	17	$	$	SYM
9z902z1424n	3	18	16.9	16.9	NUM
9z902z1424n	3	19	billion	billion	NUM
9z902z1424n	3	20	,	,	PUNCT
9z902z1424n	3	21	and	and	CCONJ
9z902z1424n	3	22	are	be	AUX
9z902z1424n	3	23	expected	expect	VERB
9z902z1424n	3	24	to	to	PART
9z902z1424n	3	25	increase	increase	VERB
9z902z1424n	3	26	to	to	ADP
9z902z1424n	3	27	more	more	ADJ
9z902z1424n	3	28	than	than	ADP
9z902z1424n	3	29	3	3	NUM
9z902z1424n	3	30	million	million	NUM
9z902z1424n	3	31	fractures	fracture	NOUN
9z902z1424n	3	32	at	at	ADP
9z902z1424n	3	33	a	a	DET
9z902z1424n	3	34	cost	cost	NOUN
9z902z1424n	3	35	of	of	ADP
9z902z1424n	3	36	$	$	SYM
9z902z1424n	3	37	25	25	NUM
9z902z1424n	3	38	billion	billion	NUM
9z902z1424n	3	39	by	by	ADP
9z902z1424n	3	40	2025	2025	NUM
9z902z1424n	3	41	.	.	PUNCT
9z902z1424n	4	1	bone	bone	NOUN
9z902z1424n	4	2	is	be	AUX
9z902z1424n	4	3	primarily	primarily	ADV
9z902z1424n	4	4	a	a	DET
9z902z1424n	4	5	load	load	NOUN
9z902z1424n	4	6	-	-	PUNCT
9z902z1424n	4	7	bearing	bear	VERB
9z902z1424n	4	8	organ	organ	NOUN
9z902z1424n	4	9	and	and	CCONJ
9z902z1424n	4	10	is	be	AUX
9z902z1424n	4	11	well	well	ADV
9z902z1424n	4	12	known	know	VERB
9z902z1424n	4	13	to	to	PART
9z902z1424n	4	14	be	be	AUX
9z902z1424n	4	15	mechanoresponsive	mechanoresponsive	ADJ
9z902z1424n	4	16	.	.	PUNCT
9z902z1424n	5	1	as	as	SCONJ
9z902z1424n	5	2	osteocyte	osteocyte	ADJ
9z902z1424n	5	3	mechanobiology	mechanobiology	NOUN
9z902z1424n	5	4	is	be	AUX
9z902z1424n	5	5	believed	believe	VERB
9z902z1424n	5	6	to	to	PART
9z902z1424n	5	7	be	be	AUX
9z902z1424n	5	8	governed	govern	VERB
9z902z1424n	5	9	by	by	ADP
9z902z1424n	5	10	fluid	fluid	ADJ
9z902z1424n	5	11	flow	flow	NOUN
9z902z1424n	5	12	in	in	ADP
9z902z1424n	5	13	bone	bone	NOUN
9z902z1424n	5	14	canaliculi	canaliculi	PROPN
9z902z1424n	5	15	,	,	PUNCT
9z902z1424n	5	16	volume	volume	NOUN
9z902z1424n	5	17	changing	change	VERB
9z902z1424n	5	18	and	and	CCONJ
9z902z1424n	5	19	volume	volume	NOUN
9z902z1424n	5	20	preserving	preserve	VERB
9z902z1424n	5	21	deformations	deformation	NOUN
9z902z1424n	5	22	may	may	AUX
9z902z1424n	5	23	play	play	VERB
9z902z1424n	5	24	distinct	distinct	ADJ
9z902z1424n	5	25	roles	role	NOUN
9z902z1424n	5	26	in	in	ADP
9z902z1424n	5	27	mechanobiology	mechanobiology	NOUN
9z902z1424n	5	28	.	.	PUNCT
9z902z1424n	6	1	thus	thus	ADV
9z902z1424n	6	2	,	,	PUNCT
9z902z1424n	6	3	improved	improve	VERB
9z902z1424n	6	4	understanding	understanding	NOUN
9z902z1424n	6	5	of	of	ADP
9z902z1424n	6	6	the	the	DET
9z902z1424n	6	7	mechanics	mechanic	NOUN
9z902z1424n	6	8	can	can	AUX
9z902z1424n	6	9	inform	inform	VERB
9z902z1424n	6	10	treatment	treatment	NOUN
9z902z1424n	6	11	strategies	strategy	NOUN
9z902z1424n	6	12	and	and	CCONJ
9z902z1424n	6	13	fracture	fracture	NOUN
9z902z1424n	6	14	prevention	prevention	NOUN
9z902z1424n	6	15	.	.	PUNCT
9z902z1424n	7	1	finite	finite	NOUN
9z902z1424n	7	2	element	element	NOUN
9z902z1424n	7	3	models	model	NOUN
9z902z1424n	7	4	of	of	ADP
9z902z1424n	7	5	porcine	porcine	NOUN
9z902z1424n	7	6	vertebral	vertebral	ADJ
9z902z1424n	7	7	trabecular	trabecular	ADJ
9z902z1424n	7	8	bone	bone	NOUN
9z902z1424n	7	9	explants	explant	NOUN
9z902z1424n	7	10	were	be	AUX
9z902z1424n	7	11	used	use	VERB
9z902z1424n	7	12	to	to	PART
9z902z1424n	7	13	calculate	calculate	VERB
9z902z1424n	7	14	the	the	DET
9z902z1424n	7	15	spatial	spatial	ADJ
9z902z1424n	7	16	strain	strain	NOUN
9z902z1424n	7	17	field	field	NOUN
9z902z1424n	7	18	.	.	PUNCT
9z902z1424n	8	1	two	two	NUM
9z902z1424n	8	2	-	-	PUNCT
9z902z1424n	8	3	point	point	NOUN
9z902z1424n	8	4	correlation	correlation	NOUN
9z902z1424n	8	5	was	be	AUX
9z902z1424n	8	6	used	use	VERB
9z902z1424n	8	7	to	to	PART
9z902z1424n	8	8	quantify	quantify	VERB
9z902z1424n	8	9	the	the	DET
9z902z1424n	8	10	spatial	spatial	ADJ
9z902z1424n	8	11	relationship	relationship	NOUN
9z902z1424n	8	12	between	between	ADP
9z902z1424n	8	13	dilatational	dilatational	ADJ
9z902z1424n	8	14	(	(	PUNCT
9z902z1424n	8	15	volume	volume	NOUN
9z902z1424n	8	16	changing	change	VERB
9z902z1424n	8	17	)	)	PUNCT
9z902z1424n	8	18	and	and	CCONJ
9z902z1424n	8	19	deviatoric	deviatoric	NOUN
9z902z1424n	8	20	(	(	PUNCT
9z902z1424n	8	21	volume	volume	NOUN
9z902z1424n	8	22	preserving	preserving	NOUN
9z902z1424n	8	23	)	)	PUNCT
9z902z1424n	8	24	strain	strain	NOUN
9z902z1424n	8	25	within	within	ADP
9z902z1424n	8	26	the	the	DET
9z902z1424n	8	27	bone	bone	NOUN
9z902z1424n	8	28	matrix	matrix	NOUN
9z902z1424n	8	29	.	.	PUNCT
9z902z1424n	9	1	the	the	DET
9z902z1424n	9	2	results	result	NOUN
9z902z1424n	9	3	consistently	consistently	ADV
9z902z1424n	9	4	showed	show	VERB
9z902z1424n	9	5	a	a	DET
9z902z1424n	9	6	strong	strong	ADJ
9z902z1424n	9	7	spatial	spatial	ADJ
9z902z1424n	9	8	relationship	relationship	NOUN
9z902z1424n	9	9	between	between	ADP
9z902z1424n	9	10	high	high	ADJ
9z902z1424n	9	11	deviatoric	deviatoric	NOUN
9z902z1424n	9	12	strain	strain	NOUN
9z902z1424n	9	13	and	and	CCONJ
9z902z1424n	9	14	negative	negative	ADJ
9z902z1424n	9	15	dilatational	dilatational	ADJ
9z902z1424n	9	16	strain	strain	NOUN
9z902z1424n	9	17	when	when	SCONJ
9z902z1424n	9	18	the	the	DET
9z902z1424n	9	19	bone	bone	NOUN
9z902z1424n	9	20	samples	sample	NOUN
9z902z1424n	9	21	were	be	AUX
9z902z1424n	9	22	subjected	subject	VERB
9z902z1424n	9	23	to	to	ADP
9z902z1424n	9	24	compression.immunohistochemistry	compression.immunohistochemistry	NOUN
9z902z1424n	9	25	was	be	AUX
9z902z1424n	9	26	coupled	couple	VERB
9z902z1424n	9	27	with	with	ADP
9z902z1424n	9	28	bioreactor	bioreactor	NOUN
9z902z1424n	9	29	culture	culture	NOUN
9z902z1424n	9	30	and	and	CCONJ
9z902z1424n	9	31	computational	computational	ADJ
9z902z1424n	9	32	modeling	modeling	NOUN
9z902z1424n	9	33	to	to	PART
9z902z1424n	9	34	link	link	VERB
9z902z1424n	9	35	local	local	ADJ
9z902z1424n	9	36	mechanical	mechanical	ADJ
9z902z1424n	9	37	behavior	behavior	NOUN
9z902z1424n	9	38	to	to	ADP
9z902z1424n	9	39	biological	biological	ADJ
9z902z1424n	9	40	response	response	NOUN
9z902z1424n	9	41	.	.	PUNCT
9z902z1424n	10	1	trabecular	trabecular	ADJ
9z902z1424n	10	2	bone	bone	NOUN
9z902z1424n	10	3	explants	explant	NOUN
9z902z1424n	10	4	from	from	ADP
9z902z1424n	10	5	female	female	ADJ
9z902z1424n	10	6	pigs	pig	NOUN
9z902z1424n	10	7	were	be	AUX
9z902z1424n	10	8	cultured	cultured	ADJ
9z902z1424n	10	9	in	in	ADP
9z902z1424n	10	10	a	a	DET
9z902z1424n	10	11	bioreactor	bioreactor	NOUN
9z902z1424n	10	12	and	and	CCONJ
9z902z1424n	10	13	subjected	subject	VERB
9z902z1424n	10	14	to	to	ADP
9z902z1424n	10	15	controlled	control	VERB
9z902z1424n	10	16	loading	loading	NOUN
9z902z1424n	10	17	.	.	PUNCT
9z902z1424n	11	1	sclerostin	sclerostin	PROPN
9z902z1424n	11	2	protein	protein	NOUN
9z902z1424n	11	3	expression	expression	NOUN
9z902z1424n	11	4	–	–	PUNCT
9z902z1424n	11	5	a	a	DET
9z902z1424n	11	6	key	key	ADJ
9z902z1424n	11	7	molecule	molecule	NOUN
9z902z1424n	11	8	regulating	regulate	VERB
9z902z1424n	11	9	osteoblast	osteoblast	NOUN
9z902z1424n	11	10	differentiation	differentiation	NOUN
9z902z1424n	11	11	was	be	AUX
9z902z1424n	11	12	compared	compare	VERB
9z902z1424n	11	13	between	between	ADP
9z902z1424n	11	14	loaded	loaded	ADJ
9z902z1424n	11	15	and	and	CCONJ
9z902z1424n	11	16	unloaded	unloaded	ADJ
9z902z1424n	11	17	samples	sample	NOUN
9z902z1424n	11	18	.	.	PUNCT
9z902z1424n	12	1	a	a	DET
9z902z1424n	12	2	greater	great	ADJ
9z902z1424n	12	3	percentage	percentage	NOUN
9z902z1424n	12	4	of	of	ADP
9z902z1424n	12	5	osteocytes	osteocyte	NOUN
9z902z1424n	12	6	expressed	express	VERB
9z902z1424n	12	7	sclerostin	sclerostin	NOUN
9z902z1424n	12	8	in	in	ADP
9z902z1424n	12	9	the	the	DET
9z902z1424n	12	10	unloaded	unloaded	ADJ
9z902z1424n	12	11	bones	bone	NOUN
9z902z1424n	12	12	.	.	PUNCT
9z902z1424n	13	1	osteocytes	osteocyte	NOUN
9z902z1424n	13	2	that	that	PRON
9z902z1424n	13	3	did	do	AUX
9z902z1424n	13	4	not	not	PART
9z902z1424n	13	5	express	express	VERB
9z902z1424n	13	6	sclerostin	sclerostin	NOUN
9z902z1424n	13	7	in	in	ADP
9z902z1424n	13	8	loaded	loaded	ADJ
9z902z1424n	13	9	bones	bone	NOUN
9z902z1424n	13	10	were	be	AUX
9z902z1424n	13	11	preferentially	preferentially	ADV
9z902z1424n	13	12	found	find	VERB
9z902z1424n	13	13	near	near	ADP
9z902z1424n	13	14	locations	location	NOUN
9z902z1424n	13	15	of	of	ADP
9z902z1424n	13	16	high	high	ADJ
9z902z1424n	13	17	deviatoric	deviatoric	NOUN
9z902z1424n	13	18	strain	strain	NOUN
9z902z1424n	13	19	.	.	PUNCT
9z902z1424n	14	1	since	since	SCONJ
9z902z1424n	14	2	the	the	DET
9z902z1424n	14	3	high	high	ADJ
9z902z1424n	14	4	deviatoric	deviatoric	NOUN
9z902z1424n	14	5	strain	strain	NOUN
9z902z1424n	14	6	locations	location	NOUN
9z902z1424n	14	7	are	be	AUX
9z902z1424n	14	8	likely	likely	ADJ
9z902z1424n	14	9	coincident	coincident	NOUN
9z902z1424n	14	10	with	with	ADP
9z902z1424n	14	11	high	high	ADJ
9z902z1424n	14	12	dilatational	dilatational	ADJ
9z902z1424n	14	13	strain	strain	NOUN
9z902z1424n	14	14	in	in	ADP
9z902z1424n	14	15	this	this	DET
9z902z1424n	14	16	loading	loading	NOUN
9z902z1424n	14	17	condition	condition	NOUN
9z902z1424n	14	18	,	,	PUNCT
9z902z1424n	14	19	it	it	PRON
9z902z1424n	14	20	may	may	AUX
9z902z1424n	14	21	not	not	PART
9z902z1424n	14	22	be	be	AUX
9z902z1424n	14	23	possible	possible	ADJ
9z902z1424n	14	24	to	to	PART
9z902z1424n	14	25	segregate	segregate	VERB
9z902z1424n	14	26	the	the	DET
9z902z1424n	14	27	specific	specific	ADJ
9z902z1424n	14	28	underlying	underlie	VERB
9z902z1424n	14	29	mechanical	mechanical	ADJ
9z902z1424n	14	30	signal	signal	NOUN
9z902z1424n	14	31	.	.	PUNCT
9z902z1424n	15	1	however	however	ADV
9z902z1424n	15	2	,	,	PUNCT
9z902z1424n	15	3	the	the	DET
9z902z1424n	15	4	results	result	NOUN
9z902z1424n	15	5	demonstrate	demonstrate	VERB
9z902z1424n	15	6	that	that	SCONJ
9z902z1424n	15	7	mechanical	mechanical	ADJ
9z902z1424n	15	8	down	down	ADJ
9z902z1424n	15	9	regulates	regulate	VERB
9z902z1424n	15	10	sclerostin	sclerostin	NOUN
9z902z1424n	15	11	expression	expression	NOUN
9z902z1424n	15	12	,	,	PUNCT
9z902z1424n	15	13	and	and	CCONJ
9z902z1424n	15	14	that	that	SCONJ
9z902z1424n	15	15	the	the	DET
9z902z1424n	15	16	effect	effect	NOUN
9z902z1424n	15	17	is	be	AUX
9z902z1424n	15	18	localized	localize	VERB
9z902z1424n	15	19	to	to	ADP
9z902z1424n	15	20	high	high	ADJ
9z902z1424n	15	21	deformation	deformation	NOUN
9z902z1424n	15	22	regions	region	NOUN
9z902z1424n	15	23	within	within	ADP
9z902z1424n	15	24	the	the	DET
9z902z1424n	15	25	trabecular	trabecular	ADJ
9z902z1424n	15	26	structure	structure	NOUN
9z902z1424n	15	27	.	.	PUNCT