id	sid	tid	token	lemma	pos
9w032229q44	1	1	plasminogen	plasminogen	NOUN
9w032229q44	1	2	activator	activator	NOUN
9w032229q44	1	3	inhibitor-1	inhibitor-1	NOUN
9w032229q44	1	4	(	(	PUNCT
9w032229q44	1	5	pai-1	pai-1	NOUN
9w032229q44	1	6	)	)	PUNCT
9w032229q44	1	7	is	be	AUX
9w032229q44	1	8	the	the	DET
9w032229q44	1	9	main	main	ADJ
9w032229q44	1	10	physiological	physiological	ADJ
9w032229q44	1	11	regulator	regulator	NOUN
9w032229q44	1	12	of	of	ADP
9w032229q44	1	13	tissue	tissue	NOUN
9w032229q44	1	14	-	-	PUNCT
9w032229q44	1	15	type	type	NOUN
9w032229q44	1	16	plasminogen	plasminogen	NOUN
9w032229q44	1	17	activator	activator	NOUN
9w032229q44	1	18	(	(	PUNCT
9w032229q44	1	19	tpa	tpa	NOUN
9w032229q44	1	20	)	)	PUNCT
9w032229q44	1	21	in	in	ADP
9w032229q44	1	22	normal	normal	ADJ
9w032229q44	1	23	plasma	plasma	NOUN
9w032229q44	1	24	.	.	PUNCT
9w032229q44	2	1	in	in	ADP
9w032229q44	2	2	addition	addition	NOUN
9w032229q44	2	3	to	to	ADP
9w032229q44	2	4	its	its	PRON
9w032229q44	2	5	critical	critical	ADJ
9w032229q44	2	6	function	function	NOUN
9w032229q44	2	7	in	in	ADP
9w032229q44	2	8	fibrinolysis	fibrinolysis	NOUN
9w032229q44	2	9	,	,	PUNCT
9w032229q44	2	10	pai-1	pai-1	VERB
9w032229q44	2	11	has	have	AUX
9w032229q44	2	12	been	be	AUX
9w032229q44	2	13	implicated	implicate	VERB
9w032229q44	2	14	in	in	ADP
9w032229q44	2	15	other	other	ADJ
9w032229q44	2	16	physiological	physiological	ADJ
9w032229q44	2	17	and	and	CCONJ
9w032229q44	2	18	pathophysiological	pathophysiological	ADJ
9w032229q44	2	19	processes	process	NOUN
9w032229q44	2	20	.	.	PUNCT
9w032229q44	3	1	interestingly	interestingly	ADV
9w032229q44	3	2	,	,	PUNCT
9w032229q44	3	3	both	both	DET
9w032229q44	3	4	antifibrinolytic	antifibrinolytic	ADJ
9w032229q44	3	5	-	-	PUNCT
9w032229q44	3	6	related	relate	VERB
9w032229q44	3	7	and	and	CCONJ
9w032229q44	3	8	non	non	ADJ
9w032229q44	3	9	-	-	ADJ
9w032229q44	3	10	antifibrinolytic	antifibrinolytic	ADJ
9w032229q44	3	11	-	-	PUNCT
9w032229q44	3	12	related	relate	VERB
9w032229q44	3	13	roles	role	NOUN
9w032229q44	3	14	of	of	ADP
9w032229q44	3	15	pai-1	pai-1	PRON
9w032229q44	3	16	function	function	NOUN
9w032229q44	3	17	have	have	AUX
9w032229q44	3	18	been	be	AUX
9w032229q44	3	19	implicated	implicate	VERB
9w032229q44	3	20	in	in	ADP
9w032229q44	3	21	the	the	DET
9w032229q44	3	22	process	process	NOUN
9w032229q44	3	23	of	of	ADP
9w032229q44	3	24	angiogenesis	angiogenesis	NOUN
9w032229q44	3	25	,	,	PUNCT
9w032229q44	3	26	which	which	PRON
9w032229q44	3	27	might	might	AUX
9w032229q44	3	28	account	account	VERB
9w032229q44	3	29	for	for	ADP
9w032229q44	3	30	some	some	DET
9w032229q44	3	31	discrepancies	discrepancy	NOUN
9w032229q44	3	32	observed	observe	VERB
9w032229q44	3	33	in	in	ADP
9w032229q44	3	34	angiogenic	angiogenic	ADJ
9w032229q44	3	35	models	model	NOUN
9w032229q44	3	36	using	use	VERB
9w032229q44	3	37	pai-1	pai-1	ADP
9w032229q44	3	38	deficient	deficient	ADJ
9w032229q44	3	39	and	and	CCONJ
9w032229q44	3	40	over	over	ADV
9w032229q44	3	41	-	-	PUNCT
9w032229q44	3	42	expressing	express	VERB
9w032229q44	3	43	transgenic	transgenic	NOUN
9w032229q44	3	44	mice	mouse	NOUN
9w032229q44	3	45	.	.	PUNCT
9w032229q44	4	1	to	to	PART
9w032229q44	4	2	investigate	investigate	VERB
9w032229q44	4	3	the	the	DET
9w032229q44	4	4	structure	structure	NOUN
9w032229q44	4	5	-	-	PUNCT
9w032229q44	4	6	function	function	NOUN
9w032229q44	4	7	relationships	relationship	NOUN
9w032229q44	4	8	of	of	ADP
9w032229q44	4	9	mouse	mouse	NOUN
9w032229q44	4	10	pai-1	pai-1	SPACE
9w032229q44	4	11	,	,	PUNCT
9w032229q44	4	12	the	the	DET
9w032229q44	4	13	recombinant	recombinant	NOUN
9w032229q44	4	14	pai-1	pai-1	ADP
9w032229q44	4	15	proteins	protein	NOUN
9w032229q44	4	16	were	be	AUX
9w032229q44	4	17	expressed	express	VERB
9w032229q44	4	18	in	in	ADP
9w032229q44	4	19	escherichia	escherichia	PROPN
9w032229q44	4	20	coli	coli	NOUN
9w032229q44	4	21	and	and	CCONJ
9w032229q44	4	22	characterized	characterize	VERB
9w032229q44	4	23	.	.	PUNCT
9w032229q44	5	1	our	our	PRON
9w032229q44	5	2	studies	study	NOUN
9w032229q44	5	3	indicated	indicate	VERB
9w032229q44	5	4	that	that	SCONJ
9w032229q44	5	5	the	the	DET
9w032229q44	5	6	complex	complex	ADJ
9w032229q44	5	7	interactions	interaction	NOUN
9w032229q44	5	8	traditionally	traditionally	ADV
9w032229q44	5	9	associated	associate	VERB
9w032229q44	5	10	with	with	ADP
9w032229q44	5	11	different	different	ADJ
9w032229q44	5	12	functions	function	NOUN
9w032229q44	5	13	of	of	ADP
9w032229q44	5	14	human	human	NOUN
9w032229q44	5	15	pai-1	pai-1	VERB
9w032229q44	5	16	apply	apply	VERB
9w032229q44	5	17	to	to	ADP
9w032229q44	5	18	the	the	DET
9w032229q44	5	19	murine	murine	NOUN
9w032229q44	5	20	system	system	NOUN
9w032229q44	5	21	,	,	PUNCT
9w032229q44	5	22	thus	thus	ADV
9w032229q44	5	23	demonstrating	demonstrate	VERB
9w032229q44	5	24	a	a	DET
9w032229q44	5	25	commonality	commonality	NOUN
9w032229q44	5	26	of	of	ADP
9w032229q44	5	27	subtle	subtle	ADJ
9w032229q44	5	28	functions	function	NOUN
9w032229q44	5	29	among	among	ADP
9w032229q44	5	30	different	different	ADJ
9w032229q44	5	31	species	specie	NOUN
9w032229q44	5	32	and	and	CCONJ
9w032229q44	5	33	evolutionary	evolutionary	ADJ
9w032229q44	5	34	conservation	conservation	NOUN
9w032229q44	5	35	of	of	ADP
9w032229q44	5	36	this	this	DET
9w032229q44	5	37	protein	protein	NOUN
9w032229q44	5	38	.	.	PUNCT
9w032229q44	6	1	in	in	ADP
9w032229q44	6	2	an	an	DET
9w032229q44	6	3	effort	effort	NOUN
9w032229q44	6	4	to	to	PART
9w032229q44	6	5	separate	separate	VERB
9w032229q44	6	6	these	these	DET
9w032229q44	6	7	functions	function	NOUN
9w032229q44	6	8	in	in	ADP
9w032229q44	6	9	vivo	vivo	PROPN
9w032229q44	6	10	,	,	PUNCT
9w032229q44	6	11	knock	knock	VERB
9w032229q44	6	12	-	-	PUNCT
9w032229q44	6	13	in	in	ADP
9w032229q44	6	14	targeting	target	VERB
9w032229q44	6	15	vector	vector	NOUN
9w032229q44	6	16	with	with	ADP
9w032229q44	6	17	targeted	target	VERB
9w032229q44	6	18	mutations	mutation	NOUN
9w032229q44	6	19	to	to	PART
9w032229q44	6	20	ablate	ablate	VERB
9w032229q44	6	21	the	the	DET
9w032229q44	6	22	vitronectin	vitronectin	NOUN
9w032229q44	6	23	binding	bind	VERB
9w032229q44	6	24	ability	ability	NOUN
9w032229q44	6	25	was	be	AUX
9w032229q44	6	26	constructed	construct	VERB
9w032229q44	6	27	.	.	PUNCT
9w032229q44	7	1	the	the	DET
9w032229q44	7	2	composition	composition	NOUN
9w032229q44	7	3	of	of	ADP
9w032229q44	7	4	the	the	DET
9w032229q44	7	5	targeting	targeting	NOUN
9w032229q44	7	6	vector	vector	NOUN
9w032229q44	7	7	includes	include	VERB
9w032229q44	7	8	the	the	DET
9w032229q44	7	9	5	5	NUM
9w032229q44	7	10	'	'	PUNCT
9w032229q44	7	11	and	and	CCONJ
9w032229q44	7	12	3	3	NUM
9w032229q44	7	13	'	'	PUNCT
9w032229q44	7	14	flanking	flank	VERB
9w032229q44	7	15	sequences	sequence	NOUN
9w032229q44	7	16	containing	contain	VERB
9w032229q44	7	17	the	the	DET
9w032229q44	7	18	mutation	mutation	NOUN
9w032229q44	7	19	,	,	PUNCT
9w032229q44	7	20	a	a	DET
9w032229q44	7	21	loxp	loxp	PROPN
9w032229q44	7	22	-	-	PUNCT
9w032229q44	7	23	flt	flt	NOUN
9w032229q44	7	24	-	-	PUNCT
9w032229q44	7	25	neo	neo	NOUN
9w032229q44	7	26	-	-	PUNCT
9w032229q44	7	27	flt	flt	ADJ
9w032229q44	7	28	-	-	PUNCT
9w032229q44	7	29	loxp	loxp	PROPN
9w032229q44	7	30	cassette	cassette	NOUN
9w032229q44	7	31	,	,	PUNCT
9w032229q44	7	32	and	and	CCONJ
9w032229q44	7	33	a	a	DET
9w032229q44	7	34	cda	cda	X
9w032229q44	7	35	expression	expression	NOUN
9w032229q44	7	36	cassette	cassette	NOUN
9w032229q44	7	37	.	.	PUNCT
9w032229q44	8	1	after	after	ADP
9w032229q44	8	2	homologous	homologous	ADJ
9w032229q44	8	3	recombination	recombination	NOUN
9w032229q44	8	4	with	with	ADP
9w032229q44	8	5	the	the	DET
9w032229q44	8	6	wt	wt	PROPN
9w032229q44	8	7	allele	allele	PROPN
9w032229q44	8	8	,	,	PUNCT
9w032229q44	8	9	the	the	DET
9w032229q44	8	10	"	"	PUNCT
9w032229q44	8	11	floxed	floxed	ADJ
9w032229q44	8	12	"	"	PUNCT
9w032229q44	8	13	cassette	cassette	NOUN
9w032229q44	8	14	may	may	AUX
9w032229q44	8	15	be	be	AUX
9w032229q44	8	16	removed	remove	VERB
9w032229q44	8	17	by	by	ADP
9w032229q44	8	18	crossing	cross	VERB
9w032229q44	8	19	with	with	ADP
9w032229q44	8	20	either	either	CCONJ
9w032229q44	8	21	cre	cre	NOUN
9w032229q44	8	22	recombinase	recombinase	NOUN
9w032229q44	8	23	or	or	CCONJ
9w032229q44	8	24	flipase	flipase	NOUN
9w032229q44	8	25	expressing	express	VERB
9w032229q44	8	26	transgenic	transgenic	NOUN
9w032229q44	8	27	mice	mouse	NOUN
9w032229q44	8	28	.	.	PUNCT
9w032229q44	9	1	a	a	DET
9w032229q44	9	2	cell	cell	NOUN
9w032229q44	9	3	culture	culture	NOUN
9w032229q44	9	4	-	-	PUNCT
9w032229q44	9	5	free	free	ADJ
9w032229q44	9	6	system	system	NOUN
9w032229q44	9	7	was	be	AUX
9w032229q44	9	8	developed	develop	VERB
9w032229q44	9	9	to	to	PART
9w032229q44	9	10	examine	examine	VERB
9w032229q44	9	11	the	the	DET
9w032229q44	9	12	cre	cre	NOUN
9w032229q44	9	13	-	-	PUNCT
9w032229q44	9	14	recombinase	recombinase	NOUN
9w032229q44	9	15	-	-	PUNCT
9w032229q44	9	16	mediated	mediate	VERB
9w032229q44	9	17	excision	excision	NOUN
9w032229q44	9	18	of	of	ADP
9w032229q44	9	19	the	the	DET
9w032229q44	9	20	"	"	PUNCT
9w032229q44	9	21	floxed	floxed	ADJ
9w032229q44	9	22	"	"	PUNCT
9w032229q44	9	23	element	element	NOUN
9w032229q44	9	24	before	before	SCONJ
9w032229q44	9	25	the	the	DET
9w032229q44	9	26	targeting	targeting	NOUN
9w032229q44	9	27	vector	vector	NOUN
9w032229q44	9	28	was	be	AUX
9w032229q44	9	29	introduced	introduce	VERB
9w032229q44	9	30	into	into	ADP
9w032229q44	9	31	the	the	DET
9w032229q44	9	32	embryonic	embryonic	ADJ
9w032229q44	9	33	stem	stem	NOUN
9w032229q44	9	34	cells	cell	NOUN
9w032229q44	9	35	.	.	PUNCT
9w032229q44	10	1	in	in	ADP
9w032229q44	10	2	order	order	NOUN
9w032229q44	10	3	to	to	PART
9w032229q44	10	4	bypass	bypass	VERB
9w032229q44	10	5	the	the	DET
9w032229q44	10	6	lengthy	lengthy	ADJ
9w032229q44	10	7	backcrossing	backcrossing	NOUN
9w032229q44	10	8	process	process	NOUN
9w032229q44	10	9	from	from	ADP
9w032229q44	10	10	the	the	DET
9w032229q44	10	11	129	129	NUM
9w032229q44	10	12	background	background	NOUN
9w032229q44	10	13	into	into	ADP
9w032229q44	10	14	the	the	DET
9w032229q44	10	15	c57bl/6	c57bl/6	PROPN
9w032229q44	10	16	background	background	NOUN
9w032229q44	10	17	,	,	PUNCT
9w032229q44	10	18	the	the	DET
9w032229q44	10	19	homologous	homologous	ADJ
9w032229q44	10	20	arms	arm	NOUN
9w032229q44	10	21	in	in	ADP
9w032229q44	10	22	the	the	DET
9w032229q44	10	23	targeting	targeting	NOUN
9w032229q44	10	24	vector	vector	NOUN
9w032229q44	10	25	were	be	AUX
9w032229q44	10	26	constructed	construct	VERB
9w032229q44	10	27	using	use	VERB
9w032229q44	10	28	a	a	DET
9w032229q44	10	29	c57bl/6	c57bl/6	ADJ
9w032229q44	10	30	genetic	genetic	ADJ
9w032229q44	10	31	background	background	NOUN
9w032229q44	10	32	to	to	PART
9w032229q44	10	33	facilitate	facilitate	VERB
9w032229q44	10	34	the	the	DET
9w032229q44	10	35	backcrossing	backcrossing	NOUN
9w032229q44	10	36	.	.	PUNCT
9w032229q44	11	1	the	the	DET
9w032229q44	11	2	targeting	targeting	NOUN
9w032229q44	11	3	vectors	vector	NOUN
9w032229q44	11	4	were	be	AUX
9w032229q44	11	5	introduced	introduce	VERB
9w032229q44	11	6	into	into	ADP
9w032229q44	11	7	both	both	PRON
9w032229q44	11	8	c57	c57	NOUN
9w032229q44	11	9	and	and	CCONJ
9w032229q44	11	10	c57/129	c57/129	NUM
9w032229q44	11	11	hybrid	hybrid	NOUN
9w032229q44	11	12	embryonic	embryonic	NOUN
9w032229q44	11	13	stem	stem	NOUN
9w032229q44	11	14	cells	cell	NOUN
9w032229q44	11	15	by	by	ADP
9w032229q44	11	16	electroporation	electroporation	NOUN
9w032229q44	11	17	,	,	PUNCT
9w032229q44	11	18	and	and	CCONJ
9w032229q44	11	19	the	the	DET
9w032229q44	11	20	homologous	homologous	ADJ
9w032229q44	11	21	recombination	recombination	NOUN
9w032229q44	11	22	was	be	AUX
9w032229q44	11	23	screened	screen	VERB
9w032229q44	11	24	by	by	ADP
9w032229q44	11	25	southern	southern	ADJ
9w032229q44	11	26	blot	blot	NOUN
9w032229q44	11	27	analysis	analysis	NOUN
9w032229q44	11	28	.	.	PUNCT
9w032229q44	12	1	positive	positive	PROPN
9w032229q44	12	2	es	es	PROPN
9w032229q44	12	3	cell	cell	NOUN
9w032229q44	12	4	clones	clone	NOUN
9w032229q44	12	5	with	with	ADP
9w032229q44	12	6	homologous	homologous	ADJ
9w032229q44	12	7	recombination	recombination	NOUN
9w032229q44	12	8	at	at	ADP
9w032229q44	12	9	both	both	DET
9w032229q44	12	10	arms	arm	NOUN
9w032229q44	12	11	were	be	AUX
9w032229q44	12	12	identified	identify	VERB
9w032229q44	12	13	.	.	PUNCT
9w032229q44	13	1	these	these	PRON
9w032229q44	13	2	pai-1	pai-1	VERB
9w032229q44	13	3	knock	knock	VERB
9w032229q44	13	4	-	-	PUNCT
9w032229q44	13	5	in	in	ADP
9w032229q44	13	6	mice	mouse	NOUN
9w032229q44	13	7	would	would	AUX
9w032229q44	13	8	serve	serve	VERB
9w032229q44	13	9	to	to	PART
9w032229q44	13	10	further	far	ADV
9w032229q44	13	11	elucidate	elucidate	VERB
9w032229q44	13	12	mechanisms	mechanism	NOUN
9w032229q44	13	13	associated	associate	VERB
9w032229q44	13	14	with	with	ADP
9w032229q44	13	15	the	the	DET
9w032229q44	13	16	observed	observed	ADJ
9w032229q44	13	17	phenotypes	phenotype	NOUN
9w032229q44	13	18	in	in	ADP
9w032229q44	13	19	pai-1	pai-1	ADP
9w032229q44	13	20	deficient	deficient	ADJ
9w032229q44	13	21	mice	mouse	NOUN
9w032229q44	13	22	in	in	ADP
9w032229q44	13	23	a	a	DET
9w032229q44	13	24	number	number	NOUN
9w032229q44	13	25	of	of	ADP
9w032229q44	13	26	challenge	challenge	NOUN
9w032229q44	13	27	models	model	NOUN
9w032229q44	13	28	.	.	PUNCT