id sid tid token lemma pos 9w032229p86 1 1 the the DET 9w032229p86 1 2 study study NOUN 9w032229p86 1 3 of of ADP 9w032229p86 1 4 parkinson parkinson PROPN 9w032229p86 1 5 's 's PART 9w032229p86 1 6 disease disease NOUN 9w032229p86 1 7 ( ( PUNCT 9w032229p86 1 8 pd pd PROPN 9w032229p86 1 9 ) ) PUNCT 9w032229p86 1 10 has have AUX 9w032229p86 1 11 mainly mainly ADV 9w032229p86 1 12 included include VERB 9w032229p86 1 13 mammalian mammalian ADJ 9w032229p86 1 14 models model NOUN 9w032229p86 1 15 treated treat VERB 9w032229p86 1 16 with with ADP 9w032229p86 1 17 neurotoxins neurotoxin NOUN 9w032229p86 1 18 that that PRON 9w032229p86 1 19 selectively selectively ADV 9w032229p86 1 20 destroy destroy VERB 9w032229p86 1 21 dopaminergic dopaminergic NOUN 9w032229p86 1 22 ( ( PUNCT 9w032229p86 1 23 da da NOUN 9w032229p86 1 24 ) ) PUNCT 9w032229p86 1 25 cells cell NOUN 9w032229p86 1 26 . . PUNCT 9w032229p86 2 1 we we PRON 9w032229p86 2 2 previously previously ADV 9w032229p86 2 3 isolated isolate VERB 9w032229p86 2 4 the the DET 9w032229p86 2 5 zebrafish zebrafish ADJ 9w032229p86 2 6 night night NOUN 9w032229p86 2 7 blindness blindness NOUN 9w032229p86 2 8 b b PROPN 9w032229p86 2 9 ( ( PUNCT 9w032229p86 2 10 nbb nbb PROPN 9w032229p86 2 11 ) ) PUNCT 9w032229p86 2 12 mutation mutation NOUN 9w032229p86 2 13 , , PUNCT 9w032229p86 2 14 which which PRON 9w032229p86 2 15 causes cause VERB 9w032229p86 2 16 a a DET 9w032229p86 2 17 progressive progressive ADJ 9w032229p86 2 18 loss loss NOUN 9w032229p86 2 19 of of ADP 9w032229p86 2 20 da da NOUN 9w032229p86 2 21 cells cell NOUN 9w032229p86 2 22 in in ADP 9w032229p86 2 23 the the DET 9w032229p86 2 24 heterozygous heterozygous ADJ 9w032229p86 2 25 adult adult NOUN 9w032229p86 2 26 retina retina NOUN 9w032229p86 2 27 and and CCONJ 9w032229p86 2 28 small small ADJ 9w032229p86 2 29 eyes eye NOUN 9w032229p86 2 30 with with ADP 9w032229p86 2 31 disorganized disorganized ADJ 9w032229p86 2 32 retinas retina NOUN 9w032229p86 2 33 in in ADP 9w032229p86 2 34 the the DET 9w032229p86 2 35 embryonic embryonic ADJ 9w032229p86 2 36 lethal lethal ADJ 9w032229p86 2 37 homozygous homozygous ADJ 9w032229p86 2 38 mutants mutant NOUN 9w032229p86 2 39 . . PUNCT 9w032229p86 3 1 in in ADP 9w032229p86 3 2 this this DET 9w032229p86 3 3 study study NOUN 9w032229p86 3 4 , , PUNCT 9w032229p86 3 5 brain brain NOUN 9w032229p86 3 6 da da NOUN 9w032229p86 3 7 neurons neuron NOUN 9w032229p86 3 8 that that PRON 9w032229p86 3 9 were be AUX 9w032229p86 3 10 comparable comparable ADJ 9w032229p86 3 11 to to ADP 9w032229p86 3 12 the the DET 9w032229p86 3 13 human human ADJ 9w032229p86 3 14 nigral nigral ADJ 9w032229p86 3 15 striatal striatal ADJ 9w032229p86 3 16 system system NOUN 9w032229p86 3 17 affected affect VERB 9w032229p86 3 18 in in ADP 9w032229p86 3 19 pd pd PROPN 9w032229p86 3 20 were be AUX 9w032229p86 3 21 examined examine VERB 9w032229p86 3 22 in in ADP 9w032229p86 3 23 aged aged ADJ 9w032229p86 3 24 heterozygous heterozygous ADJ 9w032229p86 3 25 nbb nbb PROPN 9w032229p86 3 26 mutants mutant NOUN 9w032229p86 3 27 . . PUNCT 9w032229p86 4 1 variation variation NOUN 9w032229p86 4 2 in in ADP 9w032229p86 4 3 the the DET 9w032229p86 4 4 number number NOUN 9w032229p86 4 5 of of ADP 9w032229p86 4 6 th th PROPN 9w032229p86 4 7 - - PUNCT 9w032229p86 4 8 positive positive ADJ 9w032229p86 4 9 cell cell NOUN 9w032229p86 4 10 numbers number NOUN 9w032229p86 4 11 was be AUX 9w032229p86 4 12 seen see VERB 9w032229p86 4 13 in in ADP 9w032229p86 4 14 the the DET 9w032229p86 4 15 diencephalic diencephalic ADJ 9w032229p86 4 16 posterior posterior ADJ 9w032229p86 4 17 tuberculum tuberculum NOUN 9w032229p86 4 18 in in ADP 9w032229p86 4 19 both both DET 9w032229p86 4 20 aged aged ADJ 9w032229p86 4 21 wild wild ADJ 9w032229p86 4 22 - - PUNCT 9w032229p86 4 23 type type NOUN 9w032229p86 4 24 and and CCONJ 9w032229p86 4 25 mutant mutant ADJ 9w032229p86 4 26 fish fish NOUN 9w032229p86 4 27 , , PUNCT 9w032229p86 4 28 but but CCONJ 9w032229p86 4 29 no no DET 9w032229p86 4 30 significant significant ADJ 9w032229p86 4 31 overall overall ADJ 9w032229p86 4 32 decreases decrease NOUN 9w032229p86 4 33 in in ADP 9w032229p86 4 34 average average ADJ 9w032229p86 4 35 cell cell NOUN 9w032229p86 4 36 number number NOUN 9w032229p86 4 37 were be AUX 9w032229p86 4 38 found find VERB 9w032229p86 4 39 in in ADP 9w032229p86 4 40 the the DET 9w032229p86 4 41 mutants mutant NOUN 9w032229p86 4 42 . . PUNCT 9w032229p86 5 1 identification identification NOUN 9w032229p86 5 2 of of ADP 9w032229p86 5 3 individual individual ADJ 9w032229p86 5 4 mutant mutant ADJ 9w032229p86 5 5 fish fish NOUN 9w032229p86 5 6 with with ADP 9w032229p86 5 7 cell cell NOUN 9w032229p86 5 8 numbers number NOUN 9w032229p86 5 9 lower low ADJ 9w032229p86 5 10 than than ADP 9w032229p86 5 11 wild wild ADJ 9w032229p86 5 12 - - PUNCT 9w032229p86 5 13 type type NOUN 9w032229p86 5 14 range range NOUN 9w032229p86 5 15 or or CCONJ 9w032229p86 5 16 with with ADP 9w032229p86 5 17 higher high ADJ 9w032229p86 5 18 frequency frequency NOUN 9w032229p86 5 19 of of ADP 9w032229p86 5 20 low low ADJ 9w032229p86 5 21 cell cell NOUN 9w032229p86 5 22 count count NOUN 9w032229p86 5 23 may may AUX 9w032229p86 5 24 imply imply VERB 9w032229p86 5 25 incomplete incomplete ADJ 9w032229p86 5 26 gene gene NOUN 9w032229p86 5 27 penetrance penetrance NOUN 9w032229p86 5 28 . . PUNCT 9w032229p86 6 1 previous previous ADJ 9w032229p86 6 2 cloning cloning NOUN 9w032229p86 6 3 of of ADP 9w032229p86 6 4 the the DET 9w032229p86 6 5 nbb nbb ADJ 9w032229p86 6 6 locus locus PROPN 9w032229p86 6 7 revealed reveal VERB 9w032229p86 6 8 an an DET 9w032229p86 6 9 intron intron NOUN 9w032229p86 6 10 - - PUNCT 9w032229p86 6 11 splicing splicing NOUN 9w032229p86 6 12 point point NOUN 9w032229p86 6 13 mutation mutation NOUN 9w032229p86 6 14 in in ADP 9w032229p86 6 15 the the DET 9w032229p86 6 16 scl scl NOUN 9w032229p86 6 17 / / SYM 9w032229p86 6 18 tal1 tal1 PROPN 9w032229p86 6 19 interrupting interrupt VERB 9w032229p86 6 20 locus locus NOUN 9w032229p86 6 21 ( ( PUNCT 9w032229p86 6 22 stil stil ADV 9w032229p86 6 23 ) ) PUNCT 9w032229p86 6 24 . . PUNCT 9w032229p86 7 1 complementation complementation NOUN 9w032229p86 7 2 tests test NOUN 9w032229p86 7 3 with with ADP 9w032229p86 7 4 nbb nbb PROPN 9w032229p86 7 5 and and CCONJ 9w032229p86 7 6 another another PRON 9w032229p86 7 7 zebrafish zebrafish NOUN 9w032229p86 7 8 stil stil ADV 9w032229p86 7 9 mutant mutant NOUN 9w032229p86 7 10 , , PUNCT 9w032229p86 7 11 cassiopeia cassiopeia NOUN 9w032229p86 7 12 ( ( PUNCT 9w032229p86 7 13 cspcz65 cspcz65 SPACE 9w032229p86 7 14 ) ) PUNCT 9w032229p86 7 15 , , PUNCT 9w032229p86 7 16 showed show VERB 9w032229p86 7 17 that that SCONJ 9w032229p86 7 18 the the DET 9w032229p86 7 19 two two NUM 9w032229p86 7 20 mutant mutant ADJ 9w032229p86 7 21 alleles allele NOUN 9w032229p86 7 22 did do AUX 9w032229p86 7 23 not not PART 9w032229p86 7 24 complement complement VERB 9w032229p86 7 25 . . PUNCT 9w032229p86 8 1 stil stil ADV 9w032229p86 8 2 is be AUX 9w032229p86 8 3 involved involve VERB 9w032229p86 8 4 in in ADP 9w032229p86 8 5 embryonic embryonic ADJ 9w032229p86 8 6 development development NOUN 9w032229p86 8 7 and and CCONJ 9w032229p86 8 8 cancer cancer NOUN 9w032229p86 8 9 cell cell NOUN 9w032229p86 8 10 proliferation proliferation NOUN 9w032229p86 8 11 . . PUNCT 9w032229p86 9 1 it it PRON 9w032229p86 9 2 serves serve VERB 9w032229p86 9 3 dual dual ADJ 9w032229p86 9 4 functions function NOUN 9w032229p86 9 5 as as ADP 9w032229p86 9 6 a a DET 9w032229p86 9 7 binding bind VERB 9w032229p86 9 8 partner partner NOUN 9w032229p86 9 9 to to PART 9w032229p86 9 10 sufu sufu VERB 9w032229p86 9 11 in in ADP 9w032229p86 9 12 the the DET 9w032229p86 9 13 shh shh PROPN 9w032229p86 9 14 pathway pathway NOUN 9w032229p86 9 15 , , PUNCT 9w032229p86 9 16 and and CCONJ 9w032229p86 9 17 as as ADP 9w032229p86 9 18 a a DET 9w032229p86 9 19 checkpoint checkpoint NOUN 9w032229p86 9 20 protein protein NOUN 9w032229p86 9 21 in in ADP 9w032229p86 9 22 spindle spindle NOUN 9w032229p86 9 23 pole pole NOUN 9w032229p86 9 24 formation formation NOUN 9w032229p86 9 25 during during ADP 9w032229p86 9 26 mitotic mitotic ADJ 9w032229p86 9 27 entry entry NOUN 9w032229p86 9 28 . . PUNCT 9w032229p86 10 1 to to PART 9w032229p86 10 2 further far ADV 9w032229p86 10 3 evaluate evaluate VERB 9w032229p86 10 4 novel novel NOUN 9w032229p86 10 5 mechanisms mechanism NOUN 9w032229p86 10 6 of of ADP 9w032229p86 10 7 stil stil ADV 9w032229p86 10 8 in in ADP 9w032229p86 10 9 da da NOUN 9w032229p86 10 10 cells cell NOUN 9w032229p86 10 11 , , PUNCT 9w032229p86 10 12 the the DET 9w032229p86 10 13 catecholaminergic catecholaminergic ADJ 9w032229p86 10 14 mammalian mammalian NOUN 9w032229p86 10 15 pc12 pc12 PROPN 9w032229p86 10 16 line line NOUN 9w032229p86 10 17 was be AUX 9w032229p86 10 18 used use VERB 9w032229p86 10 19 to to PART 9w032229p86 10 20 examine examine VERB 9w032229p86 10 21 its its PRON 9w032229p86 10 22 role role NOUN 9w032229p86 10 23 in in ADP 9w032229p86 10 24 da da ADJ 9w032229p86 10 25 proliferation proliferation NOUN 9w032229p86 10 26 , , PUNCT 9w032229p86 10 27 differentiation differentiation NOUN 9w032229p86 10 28 and and CCONJ 9w032229p86 10 29 survival survival NOUN 9w032229p86 10 30 . . PUNCT 9w032229p86 11 1 it it PRON 9w032229p86 11 2 was be AUX 9w032229p86 11 3 hypothesized hypothesize VERB 9w032229p86 11 4 that that SCONJ 9w032229p86 11 5 stil stil ADV 9w032229p86 11 6 would would AUX 9w032229p86 11 7 have have VERB 9w032229p86 11 8 a a DET 9w032229p86 11 9 multi multi ADJ 9w032229p86 11 10 - - ADJ 9w032229p86 11 11 functional functional ADJ 9w032229p86 11 12 role role NOUN 9w032229p86 11 13 in in ADP 9w032229p86 11 14 pc12 pc12 NOUN 9w032229p86 11 15 cells cell NOUN 9w032229p86 11 16 . . PUNCT 9w032229p86 12 1 rnai rnai ADJ 9w032229p86 12 2 knockdown knockdown NOUN 9w032229p86 12 3 of of ADP 9w032229p86 12 4 stil stil ADV 9w032229p86 12 5 yielded yield VERB 9w032229p86 12 6 a a DET 9w032229p86 12 7 decreased decrease VERB 9w032229p86 12 8 proliferation proliferation NOUN 9w032229p86 12 9 rate rate NOUN 9w032229p86 12 10 , , PUNCT 9w032229p86 12 11 whereas whereas SCONJ 9w032229p86 12 12 overexpression overexpression NOUN 9w032229p86 12 13 of of ADP 9w032229p86 12 14 the the DET 9w032229p86 12 15 human human ADJ 9w032229p86 12 16 full full ADJ 9w032229p86 12 17 - - PUNCT 9w032229p86 12 18 length length NOUN 9w032229p86 12 19 stil stil ADJ 9w032229p86 12 20 transcript transcript NOUN 9w032229p86 12 21 increased increase VERB 9w032229p86 12 22 proliferation proliferation NOUN 9w032229p86 12 23 . . PUNCT 9w032229p86 13 1 the the DET 9w032229p86 13 2 differentiation differentiation NOUN 9w032229p86 13 3 of of ADP 9w032229p86 13 4 pc12 pc12 NOUN 9w032229p86 13 5 cells cell NOUN 9w032229p86 13 6 by by ADP 9w032229p86 13 7 ngf ngf PROPN 9w032229p86 13 8 stimulated stimulate VERB 9w032229p86 13 9 stil stil ADJ 9w032229p86 13 10 expression expression NOUN 9w032229p86 13 11 in in ADP 9w032229p86 13 12 low low ADJ 9w032229p86 13 13 - - PUNCT 9w032229p86 13 14 serum serum NOUN 9w032229p86 13 15 conditions condition NOUN 9w032229p86 13 16 . . PUNCT 9w032229p86 14 1 knockdown knockdown NOUN 9w032229p86 14 2 or or CCONJ 9w032229p86 14 3 over over ADP 9w032229p86 14 4 - - PUNCT 9w032229p86 14 5 expression expression NOUN 9w032229p86 14 6 of of ADP 9w032229p86 14 7 stil stil ADV 9w032229p86 14 8 did do AUX 9w032229p86 14 9 not not PART 9w032229p86 14 10 affect affect VERB 9w032229p86 14 11 neurite neurite ADJ 9w032229p86 14 12 extension extension NOUN 9w032229p86 14 13 during during ADP 9w032229p86 14 14 differentiation differentiation NOUN 9w032229p86 14 15 . . PUNCT 9w032229p86 15 1 in in ADP 9w032229p86 15 2 cell cell NOUN 9w032229p86 15 3 survival survival NOUN 9w032229p86 15 4 assays assay VERB 9w032229p86 15 5 with with ADP 9w032229p86 15 6 6 6 NUM 9w032229p86 15 7 - - PUNCT 9w032229p86 15 8 ohda ohda NOUN 9w032229p86 15 9 , , PUNCT 9w032229p86 15 10 , , PUNCT 9w032229p86 15 11 knockdown knockdown NOUN 9w032229p86 15 12 of of ADP 9w032229p86 15 13 stil stil ADV 9w032229p86 15 14 did do AUX 9w032229p86 15 15 not not PART 9w032229p86 15 16 affect affect VERB 9w032229p86 15 17 toxin toxin NOUN 9w032229p86 15 18 sensitivity sensitivity NOUN 9w032229p86 15 19 in in ADP 9w032229p86 15 20 undifferentiated undifferentiated ADJ 9w032229p86 15 21 cells cell NOUN 9w032229p86 15 22 , , PUNCT 9w032229p86 15 23 but but CCONJ 9w032229p86 15 24 over over ADP 9w032229p86 15 25 - - PUNCT 9w032229p86 15 26 expression expression NOUN 9w032229p86 15 27 of of ADP 9w032229p86 15 28 stil stil ADV 9w032229p86 15 29 augmented augment VERB 9w032229p86 15 30 toxin toxin NOUN 9w032229p86 15 31 sensitivity sensitivity NOUN 9w032229p86 15 32 . . PUNCT 9w032229p86 16 1 in in ADP 9w032229p86 16 2 ngf ngf ADV 9w032229p86 16 3 - - PUNCT 9w032229p86 16 4 induced induce VERB 9w032229p86 16 5 cells cell NOUN 9w032229p86 16 6 , , PUNCT 9w032229p86 16 7 stil stil ADP 9w032229p86 16 8 knockdown knockdown NOUN 9w032229p86 16 9 increased increase VERB 9w032229p86 16 10 drug drug NOUN 9w032229p86 16 11 sensitivity sensitivity NOUN 9w032229p86 16 12 , , PUNCT 9w032229p86 16 13 whereas whereas SCONJ 9w032229p86 16 14 over over ADP 9w032229p86 16 15 - - PUNCT 9w032229p86 16 16 expression expression NOUN 9w032229p86 16 17 of of ADP 9w032229p86 16 18 stil stil ADV 9w032229p86 16 19 did do AUX 9w032229p86 16 20 not not PART 9w032229p86 16 21 have have VERB 9w032229p86 16 22 an an DET 9w032229p86 16 23 effect effect NOUN 9w032229p86 16 24 . . PUNCT 9w032229p86 17 1 the the DET 9w032229p86 17 2 upand upand PROPN 9w032229p86 17 3 down down ADP 9w032229p86 17 4 - - PUNCT 9w032229p86 17 5 regulation regulation NOUN 9w032229p86 17 6 of of ADP 9w032229p86 17 7 the the DET 9w032229p86 17 8 shh shh NOUN 9w032229p86 17 9 pathway pathway NOUN 9w032229p86 17 10 by by ADP 9w032229p86 17 11 pharmacological pharmacological ADJ 9w032229p86 17 12 approaches approach NOUN 9w032229p86 17 13 ( ( PUNCT 9w032229p86 17 14 e.g. e.g. X 9w032229p86 17 15 , , PUNCT 9w032229p86 17 16 cyclopamine cyclopamine NOUN 9w032229p86 17 17 and and CCONJ 9w032229p86 17 18 purmorphamine purmorphamine NOUN 9w032229p86 17 19 ) ) PUNCT 9w032229p86 17 20 demonstrated demonstrate VERB 9w032229p86 17 21 that that SCONJ 9w032229p86 17 22 stil stil ADV 9w032229p86 17 23 may may AUX 9w032229p86 17 24 function function VERB 9w032229p86 17 25 in in ADP 9w032229p86 17 26 this this DET 9w032229p86 17 27 pathway pathway NOUN 9w032229p86 17 28 for for ADP 9w032229p86 17 29 pc12 pc12 NOUN 9w032229p86 17 30 proliferation proliferation NOUN 9w032229p86 17 31 . . PUNCT 9w032229p86 18 1 results result NOUN 9w032229p86 18 2 from from ADP 9w032229p86 18 3 this this DET 9w032229p86 18 4 study study NOUN 9w032229p86 18 5 suggests suggest VERB 9w032229p86 18 6 a a DET 9w032229p86 18 7 novel novel ADJ 9w032229p86 18 8 role role NOUN 9w032229p86 18 9 for for ADP 9w032229p86 18 10 the the DET 9w032229p86 18 11 oncogene oncogene NOUN 9w032229p86 18 12 stil stil ADV 9w032229p86 18 13 in in ADP 9w032229p86 18 14 progenitor progenitor NOUN 9w032229p86 18 15 cell cell NOUN 9w032229p86 18 16 proliferation proliferation NOUN 9w032229p86 18 17 and and CCONJ 9w032229p86 18 18 survival survival NOUN 9w032229p86 18 19 of of ADP 9w032229p86 18 20 differentiated differentiated ADJ 9w032229p86 18 21 cells cell NOUN 9w032229p86 18 22 , , PUNCT 9w032229p86 18 23 and and CCONJ 9w032229p86 18 24 further far ADV 9w032229p86 18 25 introduces introduce VERB 9w032229p86 18 26 stil stil ADV 9w032229p86 18 27 as as ADP 9w032229p86 18 28 a a DET 9w032229p86 18 29 genetic genetic ADJ 9w032229p86 18 30 bio bio NOUN 9w032229p86 18 31 - - NOUN 9w032229p86 18 32 marker marker NOUN 9w032229p86 18 33 for for ADP 9w032229p86 18 34 catecholiminergic catecholiminergic ADJ 9w032229p86 18 35 ( ( PUNCT 9w032229p86 18 36 e.g. e.g. NOUN 9w032229p86 18 37 , , PUNCT 9w032229p86 18 38 da da NOUN 9w032229p86 18 39 ) ) PUNCT 9w032229p86 18 40 cells cell NOUN 9w032229p86 18 41 . . PUNCT