id	sid	tid	token	lemma	pos
9g54xg96k8r	1	1	the	the	DET
9g54xg96k8r	1	2	protein	protein	NOUN
9g54xg96k8r	1	3	-	-	PUNCT
9g54xg96k8r	1	4	protein	protein	NOUN
9g54xg96k8r	1	5	recognition	recognition	NOUN
9g54xg96k8r	1	6	event	event	NOUN
9g54xg96k8r	1	7	that	that	PRON
9g54xg96k8r	1	8	occurs	occur	VERB
9g54xg96k8r	1	9	at	at	ADP
9g54xg96k8r	1	10	the	the	DET
9g54xg96k8r	1	11	interface	interface	NOUN
9g54xg96k8r	1	12	between	between	ADP
9g54xg96k8r	1	13	a	a	DET
9g54xg96k8r	1	14	t	t	NOUN
9g54xg96k8r	1	15	cell	cell	NOUN
9g54xg96k8r	1	16	receptor	receptor	NOUN
9g54xg96k8r	1	17	(	(	PUNCT
9g54xg96k8r	1	18	tcr	tcr	PROPN
9g54xg96k8r	1	19	)	)	PUNCT
9g54xg96k8r	1	20	and	and	CCONJ
9g54xg96k8r	1	21	a	a	DET
9g54xg96k8r	1	22	peptide	peptide	NOUN
9g54xg96k8r	1	23	presented	present	VERB
9g54xg96k8r	1	24	by	by	ADP
9g54xg96k8r	1	25	a	a	DET
9g54xg96k8r	1	26	major	major	ADJ
9g54xg96k8r	1	27	histocompatibility	histocompatibility	NOUN
9g54xg96k8r	1	28	complex	complex	ADJ
9g54xg96k8r	1	29	molecule	molecule	NOUN
9g54xg96k8r	1	30	(	(	PUNCT
9g54xg96k8r	1	31	peptide	peptide	NOUN
9g54xg96k8r	1	32	/	/	SYM
9g54xg96k8r	1	33	mhc	mhc	NOUN
9g54xg96k8r	1	34	)	)	PUNCT
9g54xg96k8r	1	35	is	be	AUX
9g54xg96k8r	1	36	essential	essential	ADJ
9g54xg96k8r	1	37	to	to	ADP
9g54xg96k8r	1	38	the	the	DET
9g54xg96k8r	1	39	adaptive	adaptive	ADJ
9g54xg96k8r	1	40	immune	immune	ADJ
9g54xg96k8r	1	41	system	system	NOUN
9g54xg96k8r	1	42	.	.	PUNCT
9g54xg96k8r	2	1	this	this	DET
9g54xg96k8r	2	2	work	work	NOUN
9g54xg96k8r	2	3	examines	examine	VERB
9g54xg96k8r	2	4	tcr	tcr	NOUN
9g54xg96k8r	2	5	binding	bind	VERB
9g54xg96k8r	2	6	thermodynamics	thermodynamic	NOUN
9g54xg96k8r	2	7	and	and	CCONJ
9g54xg96k8r	2	8	compares	compare	VERB
9g54xg96k8r	2	9	these	these	DET
9g54xg96k8r	2	10	measurements	measurement	NOUN
9g54xg96k8r	2	11	to	to	ADP
9g54xg96k8r	2	12	structural	structural	ADJ
9g54xg96k8r	2	13	and	and	CCONJ
9g54xg96k8r	2	14	functional	functional	ADJ
9g54xg96k8r	2	15	features	feature	NOUN
9g54xg96k8r	2	16	to	to	PART
9g54xg96k8r	2	17	gain	gain	VERB
9g54xg96k8r	2	18	insight	insight	NOUN
9g54xg96k8r	2	19	into	into	ADP
9g54xg96k8r	2	20	the	the	DET
9g54xg96k8r	2	21	determinants	determinant	NOUN
9g54xg96k8r	2	22	of	of	ADP
9g54xg96k8r	2	23	tcr	tcr	NOUN
9g54xg96k8r	2	24	specificity	specificity	NOUN
9g54xg96k8r	2	25	,	,	PUNCT
9g54xg96k8r	2	26	cross	cross	ADJ
9g54xg96k8r	2	27	-	-	NOUN
9g54xg96k8r	2	28	reactivity	reactivity	NOUN
9g54xg96k8r	2	29	,	,	PUNCT
9g54xg96k8r	2	30	and	and	CCONJ
9g54xg96k8r	2	31	binding	binding	ADJ
9g54xg96k8r	2	32	affinity	affinity	NOUN
9g54xg96k8r	2	33	.	.	PUNCT
9g54xg96k8r	3	1	we	we	PRON
9g54xg96k8r	3	2	have	have	AUX
9g54xg96k8r	3	3	been	be	AUX
9g54xg96k8r	3	4	studying	study	VERB
9g54xg96k8r	3	5	the	the	DET
9g54xg96k8r	3	6	a6	a6	ADJ
9g54xg96k8r	3	7	tcr	tcr	NOUN
9g54xg96k8r	3	8	,	,	PUNCT
9g54xg96k8r	3	9	which	which	PRON
9g54xg96k8r	3	10	recognizes	recognize	VERB
9g54xg96k8r	3	11	the	the	DET
9g54xg96k8r	3	12	tax	tax	NOUN
9g54xg96k8r	3	13	peptide	peptide	NOUN
9g54xg96k8r	3	14	presented	present	VERB
9g54xg96k8r	3	15	by	by	ADP
9g54xg96k8r	3	16	the	the	DET
9g54xg96k8r	3	17	class	class	NOUN
9g54xg96k8r	4	1	i	i	PRON
9g54xg96k8r	4	2	mhc	mhc	INTJ
9g54xg96k8r	4	3	hla	hla	PROPN
9g54xg96k8r	4	4	-	-	PUNCT
9g54xg96k8r	4	5	a2	a2	NOUN
9g54xg96k8r	4	6	.	.	PUNCT
9g54xg96k8r	5	1	we	we	PRON
9g54xg96k8r	5	2	examined	examine	VERB
9g54xg96k8r	5	3	the	the	DET
9g54xg96k8r	5	4	a6	a6	ADJ
9g54xg96k8r	5	5	-	-	PUNCT
9g54xg96k8r	5	6	tax	tax	NOUN
9g54xg96k8r	5	7	/	/	SYM
9g54xg96k8r	5	8	hla	hla	ADJ
9g54xg96k8r	5	9	-	-	PUNCT
9g54xg96k8r	5	10	a2	a2	X
9g54xg96k8r	5	11	complex	complex	ADJ
9g54xg96k8r	5	12	formation	formation	NOUN
9g54xg96k8r	5	13	via	via	ADP
9g54xg96k8r	5	14	isothermal	isothermal	ADJ
9g54xg96k8r	5	15	titration	titration	NOUN
9g54xg96k8r	5	16	calorimetry	calorimetry	NOUN
9g54xg96k8r	5	17	(	(	PUNCT
9g54xg96k8r	5	18	itc	itc	PROPN
9g54xg96k8r	5	19	)	)	PUNCT
9g54xg96k8r	5	20	in	in	ADP
9g54xg96k8r	5	21	order	order	NOUN
9g54xg96k8r	5	22	to	to	PART
9g54xg96k8r	5	23	study	study	VERB
9g54xg96k8r	5	24	the	the	DET
9g54xg96k8r	5	25	thermodynamics	thermodynamic	NOUN
9g54xg96k8r	5	26	of	of	ADP
9g54xg96k8r	5	27	binding	bind	VERB
9g54xg96k8r	5	28	.	.	PUNCT
9g54xg96k8r	6	1	however	however	ADV
9g54xg96k8r	6	2	,	,	PUNCT
9g54xg96k8r	6	3	binding	binding	NOUN
9g54xg96k8r	6	4	caused	cause	VERB
9g54xg96k8r	6	5	a	a	DET
9g54xg96k8r	6	6	pka	pka	PROPN
9g54xg96k8r	6	7	shift	shift	NOUN
9g54xg96k8r	6	8	in	in	ADP
9g54xg96k8r	6	9	one	one	NUM
9g54xg96k8r	6	10	or	or	CCONJ
9g54xg96k8r	6	11	more	more	ADV
9g54xg96k8r	6	12	ionizable	ionizable	ADJ
9g54xg96k8r	6	13	groups	group	NOUN
9g54xg96k8r	6	14	,	,	PUNCT
9g54xg96k8r	6	15	indicated	indicate	VERB
9g54xg96k8r	6	16	by	by	ADP
9g54xg96k8r	6	17	binding	bind	VERB
9g54xg96k8r	6	18	thermodynamics	thermodynamic	NOUN
9g54xg96k8r	6	19	that	that	PRON
9g54xg96k8r	6	20	varied	vary	VERB
9g54xg96k8r	6	21	with	with	ADP
9g54xg96k8r	6	22	solution	solution	NOUN
9g54xg96k8r	6	23	conditions	condition	NOUN
9g54xg96k8r	6	24	.	.	PUNCT
9g54xg96k8r	7	1	calorimetric	calorimetric	ADJ
9g54xg96k8r	7	2	experiments	experiment	NOUN
9g54xg96k8r	7	3	with	with	ADP
9g54xg96k8r	7	4	a	a	DET
9g54xg96k8r	7	5	variety	variety	NOUN
9g54xg96k8r	7	6	of	of	ADP
9g54xg96k8r	7	7	buffers	buffer	NOUN
9g54xg96k8r	7	8	,	,	PUNCT
9g54xg96k8r	7	9	ph	ph	NOUN
9g54xg96k8r	7	10	values	value	NOUN
9g54xg96k8r	7	11	,	,	PUNCT
9g54xg96k8r	7	12	and	and	CCONJ
9g54xg96k8r	7	13	temperatures	temperature	NOUN
9g54xg96k8r	7	14	were	be	AUX
9g54xg96k8r	7	15	used	use	VERB
9g54xg96k8r	7	16	to	to	PART
9g54xg96k8r	7	17	characterize	characterize	VERB
9g54xg96k8r	7	18	the	the	DET
9g54xg96k8r	7	19	a6	a6	ADJ
9g54xg96k8r	7	20	-	-	PUNCT
9g54xg96k8r	7	21	tax	tax	NOUN
9g54xg96k8r	7	22	/	/	SYM
9g54xg96k8r	7	23	hla	hla	ADJ
9g54xg96k8r	7	24	-	-	PUNCT
9g54xg96k8r	7	25	a2	a2	ADJ
9g54xg96k8r	7	26	interaction	interaction	NOUN
9g54xg96k8r	7	27	.	.	PUNCT
9g54xg96k8r	8	1	the	the	DET
9g54xg96k8r	8	2	data	datum	NOUN
9g54xg96k8r	8	3	were	be	AUX
9g54xg96k8r	8	4	fit	fit	ADJ
9g54xg96k8r	8	5	globally	globally	ADV
9g54xg96k8r	8	6	to	to	PART
9g54xg96k8r	8	7	extract	extract	VERB
9g54xg96k8r	8	8	the	the	DET
9g54xg96k8r	8	9	intrinsic	intrinsic	ADJ
9g54xg96k8r	8	10	binding	binding	ADJ
9g54xg96k8r	8	11	thermodynamic	thermodynamic	ADJ
9g54xg96k8r	8	12	parameters	parameter	NOUN
9g54xg96k8r	8	13	.	.	PUNCT
9g54xg96k8r	9	1	these	these	DET
9g54xg96k8r	9	2	parameters	parameter	NOUN
9g54xg96k8r	9	3	were	be	AUX
9g54xg96k8r	9	4	compared	compare	VERB
9g54xg96k8r	9	5	to	to	ADP
9g54xg96k8r	9	6	structural	structural	ADJ
9g54xg96k8r	9	7	properties	property	NOUN
9g54xg96k8r	9	8	to	to	PART
9g54xg96k8r	9	9	help	help	VERB
9g54xg96k8r	9	10	elucidate	elucidate	VERB
9g54xg96k8r	9	11	the	the	DET
9g54xg96k8r	9	12	basis	basis	NOUN
9g54xg96k8r	9	13	for	for	ADP
9g54xg96k8r	9	14	molecular	molecular	ADJ
9g54xg96k8r	9	15	recognition	recognition	NOUN
9g54xg96k8r	9	16	in	in	ADP
9g54xg96k8r	9	17	this	this	DET
9g54xg96k8r	9	18	system	system	NOUN
9g54xg96k8r	9	19	.	.	PUNCT
9g54xg96k8r	10	1	additionally	additionally	ADV
9g54xg96k8r	10	2	,	,	PUNCT
9g54xg96k8r	10	3	a	a	DET
9g54xg96k8r	10	4	high	high	ADJ
9g54xg96k8r	10	5	-	-	PUNCT
9g54xg96k8r	10	6	affinity	affinity	NOUN
9g54xg96k8r	10	7	a6	a6	ADJ
9g54xg96k8r	10	8	tcr	tcr	NOUN
9g54xg96k8r	10	9	mutant	mutant	NOUN
9g54xg96k8r	10	10	,	,	PUNCT
9g54xg96k8r	10	11	a6c134	a6c134	NOUN
9g54xg96k8r	10	12	,	,	PUNCT
9g54xg96k8r	10	13	binding	bind	VERB
9g54xg96k8r	10	14	to	to	ADP
9g54xg96k8r	10	15	tax	tax	NOUN
9g54xg96k8r	10	16	/	/	SYM
9g54xg96k8r	10	17	hla	hla	NOUN
9g54xg96k8r	10	18	-	-	NOUN
9g54xg96k8r	10	19	a2	a2	PROPN
9g54xg96k8r	10	20	was	be	AUX
9g54xg96k8r	10	21	examined	examine	VERB
9g54xg96k8r	10	22	.	.	PUNCT
9g54xg96k8r	11	1	the	the	DET
9g54xg96k8r	11	2	a6c134	a6c134	ADJ
9g54xg96k8r	11	3	variant	variant	NOUN
9g54xg96k8r	11	4	has	have	VERB
9g54xg96k8r	11	5	an	an	DET
9g54xg96k8r	11	6	approximately	approximately	ADV
9g54xg96k8r	11	7	800	800	NUM
9g54xg96k8r	11	8	-	-	ADJ
9g54xg96k8r	11	9	fold	fold	VERB
9g54xg96k8r	11	10	stronger	strong	ADJ
9g54xg96k8r	11	11	affinity	affinity	NOUN
9g54xg96k8r	11	12	for	for	ADP
9g54xg96k8r	11	13	tax	tax	NOUN
9g54xg96k8r	11	14	/	/	SYM
9g54xg96k8r	11	15	hla	hla	NOUN
9g54xg96k8r	11	16	-	-	NOUN
9g54xg96k8r	11	17	a2	a2	X
9g54xg96k8r	11	18	as	as	ADV
9g54xg96k8r	11	19	measured	measure	VERB
9g54xg96k8r	11	20	by	by	ADP
9g54xg96k8r	11	21	spr	spr	ADJ
9g54xg96k8r	11	22	.	.	PUNCT
9g54xg96k8r	12	1	this	this	DET
9g54xg96k8r	12	2	increase	increase	NOUN
9g54xg96k8r	12	3	in	in	ADP
9g54xg96k8r	12	4	affinity	affinity	NOUN
9g54xg96k8r	12	5	is	be	AUX
9g54xg96k8r	12	6	due	due	ADJ
9g54xg96k8r	12	7	to	to	ADP
9g54xg96k8r	12	8	a	a	DET
9g54xg96k8r	12	9	significantly	significantly	ADV
9g54xg96k8r	12	10	slower	slow	ADJ
9g54xg96k8r	12	11	off	off	ADP
9g54xg96k8r	12	12	-	-	PUNCT
9g54xg96k8r	12	13	rate	rate	NOUN
9g54xg96k8r	12	14	for	for	ADP
9g54xg96k8r	12	15	the	the	DET
9g54xg96k8r	12	16	a6c134	a6c134	NOUN
9g54xg96k8r	12	17	-	-	PUNCT
9g54xg96k8r	12	18	tax	tax	NOUN
9g54xg96k8r	12	19	/	/	SYM
9g54xg96k8r	12	20	hla	hla	NOUN
9g54xg96k8r	12	21	-	-	PUNCT
9g54xg96k8r	12	22	a2	a2	ADJ
9g54xg96k8r	12	23	complex	complex	NOUN
9g54xg96k8r	12	24	than	than	ADP
9g54xg96k8r	12	25	for	for	ADP
9g54xg96k8r	12	26	the	the	DET
9g54xg96k8r	12	27	wild	wild	ADJ
9g54xg96k8r	12	28	-	-	PUNCT
9g54xg96k8r	12	29	type	type	NOUN
9g54xg96k8r	12	30	a6	a6	ADJ
9g54xg96k8r	12	31	counterpart	counterpart	NOUN
9g54xg96k8r	12	32	.	.	PUNCT
9g54xg96k8r	13	1	crystallographically	crystallographically	ADV
9g54xg96k8r	13	2	,	,	PUNCT
9g54xg96k8r	13	3	the	the	DET
9g54xg96k8r	13	4	topology	topology	NOUN
9g54xg96k8r	13	5	of	of	ADP
9g54xg96k8r	13	6	the	the	DET
9g54xg96k8r	13	7	mutant	mutant	ADJ
9g54xg96k8r	13	8	and	and	CCONJ
9g54xg96k8r	13	9	wild	wild	ADJ
9g54xg96k8r	13	10	-	-	PUNCT
9g54xg96k8r	13	11	type	type	NOUN
9g54xg96k8r	13	12	complex	complex	NOUN
9g54xg96k8r	13	13	are	be	AUX
9g54xg96k8r	13	14	similar	similar	ADJ
9g54xg96k8r	13	15	,	,	PUNCT
9g54xg96k8r	13	16	with	with	ADP
9g54xg96k8r	13	17	small	small	ADJ
9g54xg96k8r	13	18	differences	difference	NOUN
9g54xg96k8r	13	19	at	at	ADP
9g54xg96k8r	13	20	the	the	DET
9g54xg96k8r	13	21	interface	interface	NOUN
9g54xg96k8r	13	22	.	.	PUNCT
9g54xg96k8r	14	1	calorimetric	calorimetric	ADJ
9g54xg96k8r	14	2	data	datum	NOUN
9g54xg96k8r	14	3	indicate	indicate	VERB
9g54xg96k8r	14	4	that	that	SCONJ
9g54xg96k8r	14	5	the	the	DET
9g54xg96k8r	14	6	a6c134	a6c134	ADJ
9g54xg96k8r	14	7	mutant	mutant	NOUN
9g54xg96k8r	14	8	binds	bind	VERB
9g54xg96k8r	14	9	tax	tax	NOUN
9g54xg96k8r	14	10	/	/	SYM
9g54xg96k8r	14	11	hla	hla	NOUN
9g54xg96k8r	14	12	-	-	NOUN
9g54xg96k8r	14	13	a2	a2	NOUN
9g54xg96k8r	14	14	with	with	ADP
9g54xg96k8r	14	15	opposing	oppose	VERB
9g54xg96k8r	14	16	thermodynamics	thermodynamic	NOUN
9g54xg96k8r	14	17	as	as	SCONJ
9g54xg96k8r	14	18	compared	compare	VERB
9g54xg96k8r	14	19	to	to	ADP
9g54xg96k8r	14	20	the	the	DET
9g54xg96k8r	14	21	wild	wild	ADJ
9g54xg96k8r	14	22	-	-	PUNCT
9g54xg96k8r	14	23	type	type	NOUN
9g54xg96k8r	14	24	interaction	interaction	NOUN
9g54xg96k8r	14	25	.	.	PUNCT
9g54xg96k8r	15	1	overall	overall	ADV
9g54xg96k8r	15	2	,	,	PUNCT
9g54xg96k8r	15	3	the	the	DET
9g54xg96k8r	15	4	studies	study	NOUN
9g54xg96k8r	15	5	of	of	ADP
9g54xg96k8r	15	6	a6	a6	PROPN
9g54xg96k8r	15	7	and	and	CCONJ
9g54xg96k8r	15	8	a6c134	a6c134	ADJ
9g54xg96k8r	15	9	binding	bind	VERB
9g54xg96k8r	15	10	their	their	PRON
9g54xg96k8r	15	11	cognate	cognate	ADJ
9g54xg96k8r	15	12	ligand	ligand	NOUN
9g54xg96k8r	15	13	,	,	PUNCT
9g54xg96k8r	15	14	tax	tax	NOUN
9g54xg96k8r	15	15	/	/	SYM
9g54xg96k8r	15	16	hla	hla	NOUN
9g54xg96k8r	15	17	-	-	NOUN
9g54xg96k8r	15	18	a2	a2	NOUN
9g54xg96k8r	15	19	,	,	PUNCT
9g54xg96k8r	15	20	have	have	AUX
9g54xg96k8r	15	21	shown	show	VERB
9g54xg96k8r	15	22	that	that	SCONJ
9g54xg96k8r	15	23	each	each	DET
9g54xg96k8r	15	24	tcr	tcr	NOUN
9g54xg96k8r	15	25	binds	bind	VERB
9g54xg96k8r	15	26	with	with	ADP
9g54xg96k8r	15	27	different	different	ADJ
9g54xg96k8r	15	28	thermodynamics	thermodynamic	NOUN
9g54xg96k8r	15	29	and	and	CCONJ
9g54xg96k8r	15	30	kinetics	kinetic	NOUN
9g54xg96k8r	15	31	,	,	PUNCT
9g54xg96k8r	15	32	despite	despite	SCONJ
9g54xg96k8r	15	33	maintaining	maintain	VERB
9g54xg96k8r	15	34	similar	similar	ADJ
9g54xg96k8r	15	35	binding	bind	VERB
9g54xg96k8r	15	36	footprints	footprint	NOUN
9g54xg96k8r	15	37	.	.	PUNCT
9g54xg96k8r	16	1	further	further	ADJ
9g54xg96k8r	16	2	studies	study	NOUN
9g54xg96k8r	16	3	on	on	ADP
9g54xg96k8r	16	4	the	the	DET
9g54xg96k8r	16	5	movement	movement	NOUN
9g54xg96k8r	16	6	of	of	ADP
9g54xg96k8r	16	7	the	the	DET
9g54xg96k8r	16	8	cdr	cdr	PROPN
9g54xg96k8r	16	9	loops	loop	NOUN
9g54xg96k8r	16	10	are	be	AUX
9g54xg96k8r	16	11	proposed	propose	VERB
9g54xg96k8r	16	12	to	to	PART
9g54xg96k8r	16	13	give	give	VERB
9g54xg96k8r	16	14	insight	insight	NOUN
9g54xg96k8r	16	15	to	to	ADP
9g54xg96k8r	16	16	the	the	DET
9g54xg96k8r	16	17	ground	ground	NOUN
9g54xg96k8r	16	18	state	state	NOUN
9g54xg96k8r	16	19	of	of	ADP
9g54xg96k8r	16	20	the	the	DET
9g54xg96k8r	16	21	tcr	tcr	PROPN
9g54xg96k8r	16	22	-	-	PUNCT
9g54xg96k8r	16	23	pmhc	pmhc	NOUN
9g54xg96k8r	16	24	interaction	interaction	NOUN
9g54xg96k8r	16	25	and	and	CCONJ
9g54xg96k8r	16	26	the	the	DET
9g54xg96k8r	16	27	binding	bind	VERB
9g54xg96k8r	16	28	pathway	pathway	NOUN
9g54xg96k8r	16	29	behind	behind	ADP
9g54xg96k8r	16	30	the	the	DET
9g54xg96k8r	16	31	observed	observed	ADJ
9g54xg96k8r	16	32	thermodynamic	thermodynamic	ADJ
9g54xg96k8r	16	33	and	and	CCONJ
9g54xg96k8r	16	34	kinetic	kinetic	ADJ
9g54xg96k8r	16	35	parameters	parameter	NOUN
9g54xg96k8r	16	36	.	.	PUNCT