id	sid	tid	token	lemma	pos
9c67wm13c83	1	1	pathogenic	pathogenic	ADJ
9c67wm13c83	1	2	mycobacteria	mycobacterium	NOUN
9c67wm13c83	1	3	are	be	AUX
9c67wm13c83	1	4	a	a	DET
9c67wm13c83	1	5	global	global	ADJ
9c67wm13c83	1	6	health	health	NOUN
9c67wm13c83	1	7	problem	problem	NOUN
9c67wm13c83	1	8	.	.	PUNCT
9c67wm13c83	2	1	we	we	PRON
9c67wm13c83	2	2	use	use	VERB
9c67wm13c83	2	3	mycobacterium	mycobacterium	NOUN
9c67wm13c83	2	4	marinum	marinum	PROPN
9c67wm13c83	2	5	as	as	ADP
9c67wm13c83	2	6	a	a	DET
9c67wm13c83	2	7	model	model	NOUN
9c67wm13c83	2	8	system	system	NOUN
9c67wm13c83	2	9	for	for	ADP
9c67wm13c83	2	10	mycobacterium	mycobacterium	NOUN
9c67wm13c83	2	11	tuberculosis	tuberculosis	NOUN
9c67wm13c83	2	12	,	,	PUNCT
9c67wm13c83	2	13	the	the	DET
9c67wm13c83	2	14	causative	causative	ADJ
9c67wm13c83	2	15	agent	agent	NOUN
9c67wm13c83	2	16	of	of	ADP
9c67wm13c83	2	17	human	human	ADJ
9c67wm13c83	2	18	tuberculosis	tuberculosis	NOUN
9c67wm13c83	2	19	.	.	PUNCT
9c67wm13c83	3	1	we	we	PRON
9c67wm13c83	3	2	have	have	AUX
9c67wm13c83	3	3	developed	develop	VERB
9c67wm13c83	3	4	tools	tool	NOUN
9c67wm13c83	3	5	for	for	ADP
9c67wm13c83	3	6	studying	study	VERB
9c67wm13c83	3	7	mycobacterial	mycobacterial	ADJ
9c67wm13c83	3	8	pathogenesis	pathogenesis	NOUN
9c67wm13c83	3	9	and	and	CCONJ
9c67wm13c83	3	10	identifying	identify	VERB
9c67wm13c83	3	11	genes	gene	NOUN
9c67wm13c83	3	12	required	require	VERB
9c67wm13c83	3	13	for	for	ADP
9c67wm13c83	3	14	virulence	virulence	NOUN
9c67wm13c83	3	15	.	.	PUNCT
9c67wm13c83	4	1	the	the	DET
9c67wm13c83	4	2	esx-1	esx-1	X
9c67wm13c83	4	3	export	export	NOUN
9c67wm13c83	4	4	system	system	NOUN
9c67wm13c83	4	5	is	be	AUX
9c67wm13c83	4	6	essential	essential	ADJ
9c67wm13c83	4	7	for	for	ADP
9c67wm13c83	4	8	mycobacterial	mycobacterial	ADJ
9c67wm13c83	4	9	virulence	virulence	NOUN
9c67wm13c83	4	10	.	.	PUNCT
9c67wm13c83	5	1	we	we	PRON
9c67wm13c83	5	2	built	build	VERB
9c67wm13c83	5	3	a	a	DET
9c67wm13c83	5	4	saturating	saturate	VERB
9c67wm13c83	5	5	transposon	transposon	PROPN
9c67wm13c83	5	6	library	library	NOUN
9c67wm13c83	5	7	in	in	ADP
9c67wm13c83	5	8	m.	m.	PROPN
9c67wm13c83	5	9	marinum	marinum	PROPN
9c67wm13c83	5	10	and	and	CCONJ
9c67wm13c83	5	11	screened	screen	VERB
9c67wm13c83	5	12	for	for	ADP
9c67wm13c83	5	13	mutants	mutant	NOUN
9c67wm13c83	5	14	deficient	deficient	ADJ
9c67wm13c83	5	15	for	for	ADP
9c67wm13c83	5	16	esx-1	esx-1	DET
9c67wm13c83	5	17	export	export	NOUN
9c67wm13c83	5	18	.	.	PUNCT
9c67wm13c83	6	1	we	we	PRON
9c67wm13c83	6	2	identified	identify	VERB
9c67wm13c83	6	3	several	several	ADJ
9c67wm13c83	6	4	esx-1	esx-1	X
9c67wm13c83	6	5	-	-	PUNCT
9c67wm13c83	6	6	deficient	deficient	ADJ
9c67wm13c83	6	7	strains	strain	NOUN
9c67wm13c83	6	8	using	use	VERB
9c67wm13c83	6	9	these	these	DET
9c67wm13c83	6	10	novel	novel	NOUN
9c67wm13c83	6	11	assays	assay	NOUN
9c67wm13c83	6	12	and	and	CCONJ
9c67wm13c83	6	13	characterized	characterize	VERB
9c67wm13c83	6	14	them	they	PRON
9c67wm13c83	6	15	using	use	VERB
9c67wm13c83	6	16	molecular	molecular	ADJ
9c67wm13c83	6	17	genetics	genetic	NOUN
9c67wm13c83	6	18	,	,	PUNCT
9c67wm13c83	6	19	biochemistry	biochemistry	NOUN
9c67wm13c83	6	20	,	,	PUNCT
9c67wm13c83	6	21	and	and	CCONJ
9c67wm13c83	6	22	microbiology	microbiology	NOUN
9c67wm13c83	6	23	.	.	PUNCT
9c67wm13c83	7	1	in	in	ADP
9c67wm13c83	7	2	addition	addition	NOUN
9c67wm13c83	7	3	to	to	ADP
9c67wm13c83	7	4	genetic	genetic	ADJ
9c67wm13c83	7	5	tools	tool	NOUN
9c67wm13c83	7	6	,	,	PUNCT
9c67wm13c83	7	7	we	we	PRON
9c67wm13c83	7	8	developed	develop	VERB
9c67wm13c83	7	9	mass	mass	ADJ
9c67wm13c83	7	10	spectrometry	spectrometry	NOUN
9c67wm13c83	7	11	tools	tool	NOUN
9c67wm13c83	7	12	for	for	ADP
9c67wm13c83	7	13	monitoring	monitor	VERB
9c67wm13c83	7	14	esx-1	esx-1	SPACE
9c67wm13c83	7	15	.	.	PUNCT
9c67wm13c83	8	1	we	we	PRON
9c67wm13c83	8	2	designed	design	VERB
9c67wm13c83	8	3	and	and	CCONJ
9c67wm13c83	8	4	tested	test	VERB
9c67wm13c83	8	5	a	a	DET
9c67wm13c83	8	6	screening	screening	NOUN
9c67wm13c83	8	7	method	method	NOUN
9c67wm13c83	8	8	using	use	VERB
9c67wm13c83	8	9	maldi	maldi	PROPN
9c67wm13c83	8	10	-	-	PUNCT
9c67wm13c83	8	11	tof	tof	PROPN
9c67wm13c83	8	12	mass	mass	NOUN
9c67wm13c83	8	13	spectrometry	spectrometry	NOUN
9c67wm13c83	8	14	for	for	ADP
9c67wm13c83	8	15	high	high	ADJ
9c67wm13c83	8	16	-	-	PUNCT
9c67wm13c83	8	17	throughput	throughput	NOUN
9c67wm13c83	8	18	screening	screening	NOUN
9c67wm13c83	8	19	.	.	PUNCT
9c67wm13c83	9	1	western	western	ADJ
9c67wm13c83	9	2	blotting	blot	VERB
9c67wm13c83	9	3	for	for	ADP
9c67wm13c83	9	4	esx-1	esx-1	DET
9c67wm13c83	9	5	substrates	substrate	NOUN
9c67wm13c83	9	6	is	be	AUX
9c67wm13c83	9	7	the	the	DET
9c67wm13c83	9	8	gold	gold	ADJ
9c67wm13c83	9	9	standard	standard	NOUN
9c67wm13c83	9	10	for	for	ADP
9c67wm13c83	9	11	monitoring	monitor	VERB
9c67wm13c83	9	12	esx-1	esx-1	PRON
9c67wm13c83	9	13	function	function	NOUN
9c67wm13c83	9	14	.	.	PUNCT
9c67wm13c83	10	1	however	however	ADV
9c67wm13c83	10	2	,	,	PUNCT
9c67wm13c83	10	3	this	this	PRON
9c67wm13c83	10	4	is	be	AUX
9c67wm13c83	10	5	limited	limit	VERB
9c67wm13c83	10	6	by	by	ADP
9c67wm13c83	10	7	sensitivity	sensitivity	NOUN
9c67wm13c83	10	8	and	and	CCONJ
9c67wm13c83	10	9	antibody	antibody	NOUN
9c67wm13c83	10	10	availability	availability	NOUN
9c67wm13c83	10	11	.	.	PUNCT
9c67wm13c83	11	1	we	we	PRON
9c67wm13c83	11	2	implemented	implement	VERB
9c67wm13c83	11	3	targeted	target	VERB
9c67wm13c83	11	4	mrm	mrm	PROPN
9c67wm13c83	11	5	mass	mass	ADJ
9c67wm13c83	11	6	spectrometry	spectrometry	NOUN
9c67wm13c83	11	7	to	to	PART
9c67wm13c83	11	8	monitor	monitor	VERB
9c67wm13c83	11	9	multiple	multiple	ADJ
9c67wm13c83	11	10	esx-1	esx-1	ADP
9c67wm13c83	11	11	substrates	substrate	NOUN
9c67wm13c83	11	12	across	across	ADP
9c67wm13c83	11	13	multiple	multiple	ADJ
9c67wm13c83	11	14	strains	strain	NOUN
9c67wm13c83	11	15	to	to	PART
9c67wm13c83	11	16	elucidate	elucidate	VERB
9c67wm13c83	11	17	distinct	distinct	ADJ
9c67wm13c83	11	18	genetic	genetic	ADJ
9c67wm13c83	11	19	requirements	requirement	NOUN
9c67wm13c83	11	20	for	for	ADP
9c67wm13c83	11	21	esx-1	esx-1	PRON
9c67wm13c83	11	22	export	export	NOUN
9c67wm13c83	11	23	of	of	ADP
9c67wm13c83	11	24	several	several	ADJ
9c67wm13c83	11	25	esx-1	esx-1	ADP
9c67wm13c83	11	26	substrates.using	substrates.use	VERB
9c67wm13c83	11	27	virulence	virulence	NOUN
9c67wm13c83	11	28	assays	assay	NOUN
9c67wm13c83	11	29	,	,	PUNCT
9c67wm13c83	11	30	we	we	PRON
9c67wm13c83	11	31	identified	identify	VERB
9c67wm13c83	11	32	an	an	DET
9c67wm13c83	11	33	esx-1	esx-1	X
9c67wm13c83	11	34	-	-	PUNCT
9c67wm13c83	11	35	deficient	deficient	ADJ
9c67wm13c83	11	36	strain	strain	NOUN
9c67wm13c83	11	37	with	with	ADP
9c67wm13c83	11	38	a	a	DET
9c67wm13c83	11	39	nonsense	nonsense	NOUN
9c67wm13c83	11	40	mutation	mutation	NOUN
9c67wm13c83	11	41	in	in	ADP
9c67wm13c83	11	42	a	a	DET
9c67wm13c83	11	43	known	know	VERB
9c67wm13c83	11	44	esx-1	esx-1	SPACE
9c67wm13c83	11	45	-	-	PUNCT
9c67wm13c83	11	46	required	require	VERB
9c67wm13c83	11	47	gene	gene	NOUN
9c67wm13c83	11	48	.	.	PUNCT
9c67wm13c83	12	1	we	we	PRON
9c67wm13c83	12	2	isolated	isolate	VERB
9c67wm13c83	12	3	a	a	DET
9c67wm13c83	12	4	suppressor	suppressor	NOUN
9c67wm13c83	12	5	strain	strain	NOUN
9c67wm13c83	12	6	with	with	ADP
9c67wm13c83	12	7	the	the	DET
9c67wm13c83	12	8	nonsense	nonsense	NOUN
9c67wm13c83	12	9	mutation	mutation	NOUN
9c67wm13c83	12	10	that	that	PRON
9c67wm13c83	12	11	had	have	AUX
9c67wm13c83	12	12	restored	restore	VERB
9c67wm13c83	12	13	esx-1	esx-1	ADP
9c67wm13c83	12	14	export	export	NOUN
9c67wm13c83	12	15	and	and	CCONJ
9c67wm13c83	12	16	virulence	virulence	NOUN
9c67wm13c83	12	17	.	.	PUNCT
9c67wm13c83	13	1	we	we	PRON
9c67wm13c83	13	2	characterized	characterize	VERB
9c67wm13c83	13	3	both	both	CCONJ
9c67wm13c83	13	4	the	the	DET
9c67wm13c83	13	5	esx-1	esx-1	X
9c67wm13c83	13	6	-	-	PUNCT
9c67wm13c83	13	7	deficient	deficient	ADJ
9c67wm13c83	13	8	strain	strain	NOUN
9c67wm13c83	13	9	and	and	CCONJ
9c67wm13c83	13	10	the	the	DET
9c67wm13c83	13	11	suppressor	suppressor	NOUN
9c67wm13c83	13	12	strain	strain	VERB
9c67wm13c83	13	13	using	use	VERB
9c67wm13c83	13	14	genetics	genetic	NOUN
9c67wm13c83	13	15	,	,	PUNCT
9c67wm13c83	13	16	genomics	genomic	NOUN
9c67wm13c83	13	17	,	,	PUNCT
9c67wm13c83	13	18	biochemistry	biochemistry	NOUN
9c67wm13c83	13	19	,	,	PUNCT
9c67wm13c83	13	20	and	and	CCONJ
9c67wm13c83	13	21	bioinformatics	bioinformatic	NOUN
9c67wm13c83	13	22	.	.	PUNCT
9c67wm13c83	14	1	we	we	PRON
9c67wm13c83	14	2	found	find	VERB
9c67wm13c83	14	3	that	that	SCONJ
9c67wm13c83	14	4	suppression	suppression	NOUN
9c67wm13c83	14	5	was	be	AUX
9c67wm13c83	14	6	linked	link	VERB
9c67wm13c83	14	7	to	to	ADP
9c67wm13c83	14	8	a	a	DET
9c67wm13c83	14	9	mutation	mutation	NOUN
9c67wm13c83	14	10	in	in	ADP
9c67wm13c83	14	11	a	a	DET
9c67wm13c83	14	12	gene	gene	NOUN
9c67wm13c83	14	13	required	require	VERB
9c67wm13c83	14	14	to	to	PART
9c67wm13c83	14	15	synthesize	synthesize	VERB
9c67wm13c83	14	16	lipids.finally	lipids.finally	PROPN
9c67wm13c83	14	17	,	,	PUNCT
9c67wm13c83	14	18	we	we	PRON
9c67wm13c83	14	19	characterized	characterize	VERB
9c67wm13c83	14	20	a	a	DET
9c67wm13c83	14	21	novel	novel	ADJ
9c67wm13c83	14	22	locus	locus	NOUN
9c67wm13c83	14	23	,	,	PUNCT
9c67wm13c83	14	24	mmar_5349	mmar_5349	PROPN
9c67wm13c83	14	25	-	-	PUNCT
9c67wm13c83	14	26	mmar_5350	mmar_5350	PROPN
9c67wm13c83	14	27	.	.	PUNCT
9c67wm13c83	15	1	we	we	PRON
9c67wm13c83	15	2	demonstrated	demonstrate	VERB
9c67wm13c83	15	3	that	that	SCONJ
9c67wm13c83	15	4	mmar_5349	mmar_5349	ADV
9c67wm13c83	15	5	is	be	AUX
9c67wm13c83	15	6	involved	involve	VERB
9c67wm13c83	15	7	in	in	ADP
9c67wm13c83	15	8	multiple	multiple	ADJ
9c67wm13c83	15	9	export	export	NOUN
9c67wm13c83	15	10	systems	system	NOUN
9c67wm13c83	15	11	,	,	PUNCT
9c67wm13c83	15	12	including	include	VERB
9c67wm13c83	15	13	three	three	NUM
9c67wm13c83	15	14	separate	separate	ADJ
9c67wm13c83	15	15	esx	esx	ADJ
9c67wm13c83	15	16	systems	system	NOUN
9c67wm13c83	15	17	.	.	PUNCT
9c67wm13c83	16	1	we	we	PRON
9c67wm13c83	16	2	also	also	ADV
9c67wm13c83	16	3	showed	show	VERB
9c67wm13c83	16	4	that	that	SCONJ
9c67wm13c83	16	5	mmar_5350	mmar_5350	PROPN
9c67wm13c83	16	6	is	be	AUX
9c67wm13c83	16	7	a	a	DET
9c67wm13c83	16	8	novel	novel	ADJ
9c67wm13c83	16	9	gre	gre	NOUN
9c67wm13c83	16	10	-	-	PUNCT
9c67wm13c83	16	11	like	like	ADJ
9c67wm13c83	16	12	factor	factor	NOUN
9c67wm13c83	16	13	that	that	PRON
9c67wm13c83	16	14	induces	induce	VERB
9c67wm13c83	16	15	a	a	DET
9c67wm13c83	16	16	novel	novel	ADJ
9c67wm13c83	16	17	rna	rna	NOUN
9c67wm13c83	16	18	cleavage	cleavage	NOUN
9c67wm13c83	16	19	activity	activity	NOUN
9c67wm13c83	16	20	by	by	ADP
9c67wm13c83	16	21	rna	rna	PROPN
9c67wm13c83	16	22	polymerase	polymerase	NOUN
9c67wm13c83	16	23	and	and	CCONJ
9c67wm13c83	16	24	is	be	AUX
9c67wm13c83	16	25	involved	involve	VERB
9c67wm13c83	16	26	in	in	ADP
9c67wm13c83	16	27	the	the	DET
9c67wm13c83	16	28	temperature	temperature	NOUN
9c67wm13c83	16	29	sensitivity	sensitivity	NOUN
9c67wm13c83	16	30	of	of	ADP
9c67wm13c83	16	31	m.	m.	PROPN
9c67wm13c83	16	32	marinum	marinum	PROPN
9c67wm13c83	16	33	,	,	PUNCT
9c67wm13c83	16	34	which	which	PRON
9c67wm13c83	16	35	does	do	AUX
9c67wm13c83	16	36	not	not	PART
9c67wm13c83	16	37	typically	typically	ADV
9c67wm13c83	16	38	grow	grow	VERB
9c67wm13c83	16	39	above	above	ADP
9c67wm13c83	16	40	35	35	NUM
9c67wm13c83	16	41	°	°	NOUN
9c67wm13c83	16	42	c	c	PROPN
9c67wm13c83	16	43	.	.	PUNCT
9c67wm13c83	17	1	however	however	ADV
9c67wm13c83	17	2	,	,	PUNCT
9c67wm13c83	17	3	we	we	PRON
9c67wm13c83	17	4	found	find	VERB
9c67wm13c83	17	5	that	that	SCONJ
9c67wm13c83	17	6	deletion	deletion	NOUN
9c67wm13c83	17	7	of	of	ADP
9c67wm13c83	17	8	mmar_5350	mmar_5350	PROPN
9c67wm13c83	17	9	led	lead	VERB
9c67wm13c83	17	10	to	to	ADP
9c67wm13c83	17	11	an	an	DET
9c67wm13c83	17	12	increase	increase	NOUN
9c67wm13c83	17	13	in	in	ADP
9c67wm13c83	17	14	growth	growth	NOUN
9c67wm13c83	17	15	at	at	ADP
9c67wm13c83	17	16	37	37	NUM
9c67wm13c83	17	17	°	°	NOUN
9c67wm13c83	17	18	c	c	PROPN
9c67wm13c83	17	19	and	and	CCONJ
9c67wm13c83	17	20	overexpression	overexpression	NOUN
9c67wm13c83	17	21	of	of	ADP
9c67wm13c83	17	22	mmar_5350	mmar_5350	PROPN
9c67wm13c83	17	23	completely	completely	ADV
9c67wm13c83	17	24	abrogated	abrogate	VERB
9c67wm13c83	17	25	growth	growth	NOUN
9c67wm13c83	17	26	at	at	ADP
9c67wm13c83	17	27	37°c.through	37°c.through	PROPN
9c67wm13c83	17	28	these	these	DET
9c67wm13c83	17	29	studies	study	NOUN
9c67wm13c83	17	30	we	we	PRON
9c67wm13c83	17	31	have	have	AUX
9c67wm13c83	17	32	characterized	characterize	VERB
9c67wm13c83	17	33	several	several	ADJ
9c67wm13c83	17	34	mechanisms	mechanism	NOUN
9c67wm13c83	17	35	by	by	ADP
9c67wm13c83	17	36	which	which	PRON
9c67wm13c83	17	37	pathogenic	pathogenic	ADJ
9c67wm13c83	17	38	mycobacteria	mycobacterium	NOUN
9c67wm13c83	17	39	survive	survive	VERB
9c67wm13c83	17	40	in	in	ADP
9c67wm13c83	17	41	their	their	PRON
9c67wm13c83	17	42	host	host	NOUN
9c67wm13c83	17	43	environment	environment	NOUN
9c67wm13c83	17	44	and	and	CCONJ
9c67wm13c83	17	45	cause	cause	VERB
9c67wm13c83	17	46	disease	disease	NOUN
9c67wm13c83	17	47	.	.	PUNCT
9c67wm13c83	18	1	these	these	DET
9c67wm13c83	18	2	studies	study	NOUN
9c67wm13c83	18	3	add	add	VERB
9c67wm13c83	18	4	to	to	ADP
9c67wm13c83	18	5	our	our	PRON
9c67wm13c83	18	6	knowledge	knowledge	NOUN
9c67wm13c83	18	7	base	base	NOUN
9c67wm13c83	18	8	to	to	PART
9c67wm13c83	18	9	help	help	VERB
9c67wm13c83	18	10	develop	develop	VERB
9c67wm13c83	18	11	novel	novel	ADJ
9c67wm13c83	18	12	strategies	strategy	NOUN
9c67wm13c83	18	13	of	of	ADP
9c67wm13c83	18	14	fighting	fight	VERB
9c67wm13c83	18	15	these	these	DET
9c67wm13c83	18	16	pathogens	pathogen	NOUN
9c67wm13c83	18	17	.	.	PUNCT