id	sid	tid	token	lemma	pos
9880vq30153	1	1	malaria	malaria	NOUN
9880vq30153	1	2	effects	effect	NOUN
9880vq30153	1	3	nearly	nearly	ADV
9880vq30153	1	4	a	a	PRON
9880vq30153	1	5	quarter	quarter	NOUN
9880vq30153	1	6	of	of	ADP
9880vq30153	1	7	a	a	DET
9880vq30153	1	8	billion	billion	NUM
9880vq30153	1	9	people	people	NOUN
9880vq30153	1	10	each	each	DET
9880vq30153	1	11	year	year	NOUN
9880vq30153	1	12	.	.	PUNCT
9880vq30153	2	1	efforts	effort	NOUN
9880vq30153	2	2	to	to	PART
9880vq30153	2	3	control	control	VERB
9880vq30153	2	4	the	the	DET
9880vq30153	2	5	disease	disease	NOUN
9880vq30153	2	6	have	have	AUX
9880vq30153	2	7	been	be	AUX
9880vq30153	2	8	hampered	hamper	VERB
9880vq30153	2	9	by	by	ADP
9880vq30153	2	10	the	the	DET
9880vq30153	2	11	development	development	NOUN
9880vq30153	2	12	of	of	ADP
9880vq30153	2	13	drug	drug	NOUN
9880vq30153	2	14	resistance	resistance	NOUN
9880vq30153	2	15	in	in	ADP
9880vq30153	2	16	the	the	DET
9880vq30153	2	17	plasmodium	plasmodium	NOUN
9880vq30153	2	18	parasite	parasite	NOUN
9880vq30153	2	19	.	.	PUNCT
9880vq30153	3	1	this	this	DET
9880vq30153	3	2	history	history	NOUN
9880vq30153	3	3	of	of	ADP
9880vq30153	3	4	drug	drug	NOUN
9880vq30153	3	5	selections	selection	NOUN
9880vq30153	3	6	on	on	ADP
9880vq30153	3	7	the	the	DET
9880vq30153	3	8	parasite	parasite	NOUN
9880vq30153	3	9	have	have	AUX
9880vq30153	3	10	shaped	shape	VERB
9880vq30153	3	11	its	its	PRON
9880vq30153	3	12	genome	genome	NOUN
9880vq30153	3	13	,	,	PUNCT
9880vq30153	3	14	enhancing	enhance	VERB
9880vq30153	3	15	drug	drug	NOUN
9880vq30153	3	16	resistance	resistance	NOUN
9880vq30153	3	17	and	and	CCONJ
9880vq30153	3	18	compensating	compensate	VERB
9880vq30153	3	19	for	for	ADP
9880vq30153	3	20	fitness	fitness	NOUN
9880vq30153	3	21	costs	cost	NOUN
9880vq30153	3	22	associated	associate	VERB
9880vq30153	3	23	with	with	ADP
9880vq30153	3	24	the	the	DET
9880vq30153	3	25	resistance	resistance	NOUN
9880vq30153	3	26	phenotype	phenotype	NOUN
9880vq30153	3	27	.	.	PUNCT
9880vq30153	4	1	the	the	DET
9880vq30153	4	2	reshaping	reshaping	NOUN
9880vq30153	4	3	of	of	ADP
9880vq30153	4	4	drug	drug	NOUN
9880vq30153	4	5	resistant	resistant	ADJ
9880vq30153	4	6	parasite	parasite	NOUN
9880vq30153	4	7	genomes	genome	NOUN
9880vq30153	4	8	will	will	AUX
9880vq30153	4	9	constrain	constrain	VERB
9880vq30153	4	10	loci	locus	NOUN
9880vq30153	4	11	particularly	particularly	ADV
9880vq30153	4	12	important	important	ADJ
9880vq30153	4	13	to	to	PART
9880vq30153	4	14	parasite	parasite	VERB
9880vq30153	4	15	fitness	fitness	NOUN
9880vq30153	4	16	.	.	PUNCT
9880vq30153	5	1	consistent	consistent	ADJ
9880vq30153	5	2	with	with	ADP
9880vq30153	5	3	the	the	DET
9880vq30153	5	4	hypothesis	hypothesis	NOUN
9880vq30153	5	5	that	that	SCONJ
9880vq30153	5	6	the	the	DET
9880vq30153	5	7	genome	genome	NOUN
9880vq30153	5	8	of	of	ADP
9880vq30153	5	9	the	the	DET
9880vq30153	5	10	drug	drug	NOUN
9880vq30153	5	11	resistant	resistant	ADJ
9880vq30153	5	12	dd2	dd2	PROPN
9880vq30153	5	13	parent	parent	NOUN
9880vq30153	5	14	has	have	AUX
9880vq30153	5	15	been	be	AUX
9880vq30153	5	16	fined	fine	VERB
9880vq30153	5	17	tuned	tune	VERB
9880vq30153	5	18	to	to	PART
9880vq30153	5	19	compensate	compensate	VERB
9880vq30153	5	20	for	for	ADP
9880vq30153	5	21	the	the	DET
9880vq30153	5	22	effects	effect	NOUN
9880vq30153	5	23	of	of	ADP
9880vq30153	5	24	drug	drug	NOUN
9880vq30153	5	25	resistantce	resistantce	PROPN
9880vq30153	5	26	we	we	PRON
9880vq30153	5	27	found	find	VERB
9880vq30153	5	28	that	that	SCONJ
9880vq30153	5	29	parental	parental	ADJ
9880vq30153	5	30	allele	allele	NOUN
9880vq30153	5	31	combinations	combination	NOUN
9880vq30153	5	32	were	be	AUX
9880vq30153	5	33	found	find	VERB
9880vq30153	5	34	at	at	ADP
9880vq30153	5	35	a	a	DET
9880vq30153	5	36	greater	great	ADJ
9880vq30153	5	37	frequency	frequency	NOUN
9880vq30153	5	38	in	in	ADP
9880vq30153	5	39	the	the	DET
9880vq30153	5	40	progeny	progeny	NOUN
9880vq30153	5	41	of	of	ADP
9880vq30153	5	42	a	a	DET
9880vq30153	5	43	genetic	genetic	ADJ
9880vq30153	5	44	cross	cross	NOUN
9880vq30153	5	45	.	.	PUNCT
9880vq30153	6	1	growth	growth	NOUN
9880vq30153	6	2	dynamics	dynamic	NOUN
9880vq30153	6	3	of	of	ADP
9880vq30153	6	4	individual	individual	ADJ
9880vq30153	6	5	parasite	parasite	NOUN
9880vq30153	6	6	clones	clone	NOUN
9880vq30153	6	7	in	in	ADP
9880vq30153	6	8	mixed	mixed	ADJ
9880vq30153	6	9	infections	infection	NOUN
9880vq30153	6	10	were	be	AUX
9880vq30153	6	11	further	far	ADV
9880vq30153	6	12	investigated	investigate	VERB
9880vq30153	6	13	through	through	ADP
9880vq30153	6	14	the	the	DET
9880vq30153	6	15	development	development	NOUN
9880vq30153	6	16	of	of	ADP
9880vq30153	6	17	a	a	DET
9880vq30153	6	18	quantitative	quantitative	ADJ
9880vq30153	6	19	competition	competition	NOUN
9880vq30153	6	20	assay	assay	NOUN
9880vq30153	6	21	that	that	PRON
9880vq30153	6	22	allowed	allow	VERB
9880vq30153	6	23	for	for	ADP
9880vq30153	6	24	precise	precise	ADJ
9880vq30153	6	25	quantitifiation	quantitifiation	NOUN
9880vq30153	6	26	of	of	ADP
9880vq30153	6	27	growth	growth	NOUN
9880vq30153	6	28	dynamics	dynamic	NOUN
9880vq30153	6	29	,	,	PUNCT
9880vq30153	6	30	specifically	specifically	ADV
9880vq30153	6	31	the	the	DET
9880vq30153	6	32	absolute	absolute	ADJ
9880vq30153	6	33	quantification	quantification	NOUN
9880vq30153	6	34	of	of	ADP
9880vq30153	6	35	each	each	DET
9880vq30153	6	36	parasite	parasite	NOUN
9880vq30153	6	37	within	within	ADP
9880vq30153	6	38	a	a	DET
9880vq30153	6	39	multiclonal	multiclonal	ADJ
9880vq30153	6	40	infection	infection	NOUN
9880vq30153	6	41	.	.	PUNCT
9880vq30153	7	1	in	in	ADP
9880vq30153	7	2	a	a	DET
9880vq30153	7	3	mixed	mixed	ADJ
9880vq30153	7	4	infection	infection	NOUN
9880vq30153	7	5	consisting	consist	VERB
9880vq30153	7	6	of	of	ADP
9880vq30153	7	7	drug	drug	NOUN
9880vq30153	7	8	sensitive	sensitive	ADJ
9880vq30153	7	9	and	and	CCONJ
9880vq30153	7	10	drug	drug	NOUN
9880vq30153	7	11	resistant	resistant	ADJ
9880vq30153	7	12	parasites	parasite	NOUN
9880vq30153	7	13	the	the	DET
9880vq30153	7	14	application	application	NOUN
9880vq30153	7	15	of	of	ADP
9880vq30153	7	16	drug	drug	NOUN
9880vq30153	7	17	pressure	pressure	NOUN
9880vq30153	7	18	leads	lead	VERB
9880vq30153	7	19	to	to	ADP
9880vq30153	7	20	the	the	DET
9880vq30153	7	21	competitive	competitive	ADJ
9880vq30153	7	22	release	release	NOUN
9880vq30153	7	23	of	of	ADP
9880vq30153	7	24	the	the	DET
9880vq30153	7	25	drug	drug	NOUN
9880vq30153	7	26	resistant	resistant	ADJ
9880vq30153	7	27	parasite	parasite	NOUN
9880vq30153	7	28	.	.	PUNCT
9880vq30153	8	1	impact	impact	NOUN
9880vq30153	8	2	of	of	ADP
9880vq30153	8	3	drug	drug	NOUN
9880vq30153	8	4	selection	selection	NOUN
9880vq30153	8	5	on	on	ADP
9880vq30153	8	6	parasite	parasite	NOUN
9880vq30153	8	7	physiology	physiology	NOUN
9880vq30153	8	8	was	be	AUX
9880vq30153	8	9	investigated	investigate	VERB
9880vq30153	8	10	by	by	ADP
9880vq30153	8	11	coupling	couple	VERB
9880vq30153	8	12	global	global	ADJ
9880vq30153	8	13	metabolite	metabolite	PROPN
9880vq30153	8	14	analysis	analysis	NOUN
9880vq30153	8	15	and	and	CCONJ
9880vq30153	8	16	qtl	qtl	PROPN
9880vq30153	8	17	mapping	mapping	NOUN
9880vq30153	8	18	.	.	PUNCT
9880vq30153	9	1	we	we	PRON
9880vq30153	9	2	propose	propose	VERB
9880vq30153	9	3	that	that	SCONJ
9880vq30153	9	4	the	the	DET
9880vq30153	9	5	endogenous	endogenous	ADJ
9880vq30153	9	6	function	function	NOUN
9880vq30153	9	7	of	of	ADP
9880vq30153	9	8	pfcrt	pfcrt	NOUN
9880vq30153	9	9	is	be	AUX
9880vq30153	9	10	the	the	DET
9880vq30153	9	11	transport	transport	NOUN
9880vq30153	9	12	of	of	ADP
9880vq30153	9	13	these	these	DET
9880vq30153	9	14	small	small	ADJ
9880vq30153	9	15	peptides	peptide	NOUN
9880vq30153	9	16	from	from	ADP
9880vq30153	9	17	the	the	DET
9880vq30153	9	18	digestive	digestive	ADJ
9880vq30153	9	19	vacuole	vacuole	NOUN
9880vq30153	9	20	of	of	ADP
9880vq30153	9	21	the	the	DET
9880vq30153	9	22	parasite	parasite	NOUN
9880vq30153	9	23	to	to	ADP
9880vq30153	9	24	cytoplasm	cytoplasm	NOUN
9880vq30153	9	25	.	.	PUNCT
9880vq30153	10	1	knowledge	knowledge	NOUN
9880vq30153	10	2	of	of	ADP
9880vq30153	10	3	the	the	DET
9880vq30153	10	4	endogenous	endogenous	ADJ
9880vq30153	10	5	fuction	fuction	NOUN
9880vq30153	10	6	of	of	ADP
9880vq30153	10	7	pfcrt	pfcrt	NOUN
9880vq30153	10	8	is	be	AUX
9880vq30153	10	9	necessary	necessary	ADJ
9880vq30153	10	10	to	to	PART
9880vq30153	10	11	begin	begin	VERB
9880vq30153	10	12	to	to	PART
9880vq30153	10	13	understand	understand	VERB
9880vq30153	10	14	how	how	SCONJ
9880vq30153	10	15	drug	drug	NOUN
9880vq30153	10	16	resistant	resistant	ADJ
9880vq30153	10	17	parasites	parasite	NOUN
9880vq30153	10	18	may	may	AUX
9880vq30153	10	19	have	have	AUX
9880vq30153	10	20	adapted	adapt	VERB
9880vq30153	10	21	to	to	PART
9880vq30153	10	22	compensate	compensate	VERB
9880vq30153	10	23	for	for	ADP
9880vq30153	10	24	any	any	DET
9880vq30153	10	25	fitness	fitness	NOUN
9880vq30153	10	26	costs	cost	NOUN
9880vq30153	10	27	associated	associate	VERB
9880vq30153	10	28	with	with	ADP
9880vq30153	10	29	resistance	resistance	NOUN
9880vq30153	10	30	mutations	mutation	NOUN
9880vq30153	10	31	.	.	PUNCT
9880vq30153	11	1	the	the	DET
9880vq30153	11	2	compiliation	compiliation	NOUN
9880vq30153	11	3	of	of	ADP
9880vq30153	11	4	this	this	DET
9880vq30153	11	5	work	work	NOUN
9880vq30153	11	6	strongly	strongly	ADV
9880vq30153	11	7	supports	support	VERB
9880vq30153	11	8	the	the	DET
9880vq30153	11	9	existence	existence	NOUN
9880vq30153	11	10	of	of	ADP
9880vq30153	11	11	,	,	PUNCT
9880vq30153	11	12	and	and	CCONJ
9880vq30153	11	13	identifies	identify	VERB
9880vq30153	11	14	key	key	ADJ
9880vq30153	11	15	molecular	molecular	ADJ
9880vq30153	11	16	components	component	NOUN
9880vq30153	11	17	of	of	ADP
9880vq30153	11	18	,	,	PUNCT
9880vq30153	11	19	the	the	DET
9880vq30153	11	20	relationship	relationship	NOUN
9880vq30153	11	21	between	between	ADP
9880vq30153	11	22	past	past	ADJ
9880vq30153	11	23	drug	drug	NOUN
9880vq30153	11	24	selection	selection	NOUN
9880vq30153	11	25	bottlenecks	bottleneck	NOUN
9880vq30153	11	26	and	and	CCONJ
9880vq30153	11	27	growth	growth	NOUN
9880vq30153	11	28	/	/	SYM
9880vq30153	11	29	fitness	fitness	NOUN
9880vq30153	11	30	traits	trait	NOUN
9880vq30153	11	31	.	.	PUNCT
9880vq30153	12	1	these	these	DET
9880vq30153	12	2	compensatory	compensatory	ADJ
9880vq30153	12	3	changes	change	NOUN
9880vq30153	12	4	could	could	AUX
9880vq30153	12	5	play	play	VERB
9880vq30153	12	6	critical	critical	ADJ
9880vq30153	12	7	roles	role	NOUN
9880vq30153	12	8	in	in	ADP
9880vq30153	12	9	the	the	DET
9880vq30153	12	10	origin	origin	NOUN
9880vq30153	12	11	,	,	PUNCT
9880vq30153	12	12	persistence	persistence	NOUN
9880vq30153	12	13	and	and	CCONJ
9880vq30153	12	14	spread	spread	NOUN
9880vq30153	12	15	of	of	ADP
9880vq30153	12	16	drug	drug	NOUN
9880vq30153	12	17	resistant	resistant	ADJ
9880vq30153	12	18	parasite	parasite	NOUN
9880vq30153	12	19	populations	population	NOUN
9880vq30153	12	20	that	that	PRON
9880vq30153	12	21	have	have	AUX
9880vq30153	12	22	been	be	AUX
9880vq30153	12	23	argued	argue	VERB
9880vq30153	12	24	to	to	PART
9880vq30153	12	25	be	be	AUX
9880vq30153	12	26	more	more	ADV
9880vq30153	12	27	virulent	virulent	ADJ
9880vq30153	12	28	and	and	CCONJ
9880vq30153	12	29	prone	prone	ADJ
9880vq30153	12	30	to	to	ADP
9880vq30153	12	31	rapid	rapid	ADJ
9880vq30153	12	32	resistance	resistance	NOUN
9880vq30153	12	33	to	to	ADP
9880vq30153	12	34	new	new	ADJ
9880vq30153	12	35	drugs	drug	NOUN
9880vq30153	12	36	.	.	PUNCT
9880vq30153	13	1	knowledge	knowledge	NOUN
9880vq30153	13	2	of	of	ADP
9880vq30153	13	3	these	these	DET
9880vq30153	13	4	pathways	pathway	NOUN
9880vq30153	13	5	and	and	CCONJ
9880vq30153	13	6	mechanisms	mechanism	NOUN
9880vq30153	13	7	will	will	AUX
9880vq30153	13	8	also	also	ADV
9880vq30153	13	9	reveal	reveal	VERB
9880vq30153	13	10	new	new	ADJ
9880vq30153	13	11	drug	drug	NOUN
9880vq30153	13	12	targets	target	NOUN
9880vq30153	13	13	,	,	PUNCT
9880vq30153	13	14	unique	unique	ADJ
9880vq30153	13	15	to	to	ADP
9880vq30153	13	16	drug	drug	NOUN
9880vq30153	13	17	resistant	resistant	ADJ
9880vq30153	13	18	parasites	parasite	NOUN
9880vq30153	13	19	,	,	PUNCT
9880vq30153	13	20	and	and	CCONJ
9880vq30153	13	21	could	could	AUX
9880vq30153	13	22	facilitate	facilitate	VERB
9880vq30153	13	23	the	the	DET
9880vq30153	13	24	rational	rational	ADJ
9880vq30153	13	25	design	design	NOUN
9880vq30153	13	26	of	of	ADP
9880vq30153	13	27	drug	drug	NOUN
9880vq30153	13	28	combinations	combination	NOUN
9880vq30153	13	29	to	to	PART
9880vq30153	13	30	thwart	thwart	VERB
9880vq30153	13	31	the	the	DET
9880vq30153	13	32	ever	ever	ADV
9880vq30153	13	33	-	-	PUNCT
9880vq30153	13	34	emerging	emerge	VERB
9880vq30153	13	35	scourge	scourge	NOUN
9880vq30153	13	36	of	of	ADP
9880vq30153	13	37	multi	multi	ADJ
9880vq30153	13	38	-	-	ADJ
9880vq30153	13	39	drug	drug	ADJ
9880vq30153	13	40	resistant	resistant	ADJ
9880vq30153	13	41	malaria	malaria	NOUN
9880vq30153	13	42	.	.	PUNCT