id sid tid token lemma pos 9880vq3005s 1 1 p190b p190b ADV 9880vq3005s 1 2 rhogap rhogap PROPN 9880vq3005s 1 3 is be AUX 9880vq3005s 1 4 a a DET 9880vq3005s 1 5 negative negative ADJ 9880vq3005s 1 6 regulator regulator NOUN 9880vq3005s 1 7 of of ADP 9880vq3005s 1 8 the the DET 9880vq3005s 1 9 rho rho NOUN 9880vq3005s 1 10 gtpase gtpase NOUN 9880vq3005s 1 11 signaling signal VERB 9880vq3005s 1 12 pathway pathway NOUN 9880vq3005s 1 13 . . PUNCT 9880vq3005s 2 1 rho rho PROPN 9880vq3005s 2 2 signaling signaling NOUN 9880vq3005s 2 3 is be AUX 9880vq3005s 2 4 involved involve VERB 9880vq3005s 2 5 in in ADP 9880vq3005s 2 6 proliferation proliferation NOUN 9880vq3005s 2 7 , , PUNCT 9880vq3005s 2 8 migration migration NOUN 9880vq3005s 2 9 , , PUNCT 9880vq3005s 2 10 polarity polarity NOUN 9880vq3005s 2 11 and and CCONJ 9880vq3005s 2 12 cytoskeletal cytoskeletal ADJ 9880vq3005s 2 13 rearrangement rearrangement NOUN 9880vq3005s 2 14 . . PUNCT 9880vq3005s 3 1 it it PRON 9880vq3005s 3 2 has have AUX 9880vq3005s 3 3 also also ADV 9880vq3005s 3 4 been be AUX 9880vq3005s 3 5 shown show VERB 9880vq3005s 3 6 to to PART 9880vq3005s 3 7 be be AUX 9880vq3005s 3 8 elevated elevate VERB 9880vq3005s 3 9 in in ADP 9880vq3005s 3 10 many many ADJ 9880vq3005s 3 11 forms form NOUN 9880vq3005s 3 12 of of ADP 9880vq3005s 3 13 cancer cancer NOUN 9880vq3005s 3 14 . . PUNCT 9880vq3005s 4 1 in in ADP 9880vq3005s 4 2 the the DET 9880vq3005s 4 3 developing develop VERB 9880vq3005s 4 4 mouse mouse NOUN 9880vq3005s 4 5 mammary mammary ADJ 9880vq3005s 4 6 gland gland NOUN 9880vq3005s 4 7 p190b p190b ADV 9880vq3005s 4 8 is be AUX 9880vq3005s 4 9 expressed express VERB 9880vq3005s 4 10 in in ADP 9880vq3005s 4 11 the the DET 9880vq3005s 4 12 terminal terminal ADJ 9880vq3005s 4 13 end end NOUN 9880vq3005s 4 14 buds(tebs buds(tebs PROPN 9880vq3005s 4 15 ) ) PUNCT 9880vq3005s 4 16 , , PUNCT 9880vq3005s 4 17 which which PRON 9880vq3005s 4 18 are be AUX 9880vq3005s 4 19 the the DET 9880vq3005s 4 20 proliferative proliferative ADJ 9880vq3005s 4 21 structures structure NOUN 9880vq3005s 4 22 responsible responsible ADJ 9880vq3005s 4 23 for for ADP 9880vq3005s 4 24 expanding expand VERB 9880vq3005s 4 25 the the DET 9880vq3005s 4 26 ductal ductal ADJ 9880vq3005s 4 27 system system NOUN 9880vq3005s 4 28 into into ADP 9880vq3005s 4 29 the the DET 9880vq3005s 4 30 mammary mammary ADJ 9880vq3005s 4 31 fat fat ADJ 9880vq3005s 4 32 pad pad NOUN 9880vq3005s 4 33 during during ADP 9880vq3005s 4 34 virgin virgin PROPN 9880vq3005s 4 35 mammary mammary ADJ 9880vq3005s 4 36 gland gland PROPN 9880vq3005s 4 37 development development NOUN 9880vq3005s 4 38 . . PUNCT 9880vq3005s 5 1 overexpression overexpression NOUN 9880vq3005s 5 2 of of ADP 9880vq3005s 5 3 p190b p190b ADV 9880vq3005s 5 4 during during ADP 9880vq3005s 5 5 development development NOUN 9880vq3005s 5 6 leads lead VERB 9880vq3005s 5 7 to to ADP 9880vq3005s 5 8 disruption disruption NOUN 9880vq3005s 5 9 of of ADP 9880vq3005s 5 10 the the DET 9880vq3005s 5 11 stromal stromal ADJ 9880vq3005s 5 12 composition composition NOUN 9880vq3005s 5 13 of of ADP 9880vq3005s 5 14 the the DET 9880vq3005s 5 15 tebs tebs NOUN 9880vq3005s 5 16 . . PUNCT 9880vq3005s 6 1 in in ADP 9880vq3005s 6 2 addition addition NOUN 9880vq3005s 6 3 , , PUNCT 9880vq3005s 6 4 ductal ductal PROPN 9880vq3005s 6 5 tree tree NOUN 9880vq3005s 6 6 expansion expansion NOUN 9880vq3005s 6 7 and and CCONJ 9880vq3005s 6 8 morphology morphology NOUN 9880vq3005s 6 9 is be AUX 9880vq3005s 6 10 abnormal abnormal ADJ 9880vq3005s 6 11 and and CCONJ 9880vq3005s 6 12 is be AUX 9880vq3005s 6 13 characterized characterize VERB 9880vq3005s 6 14 by by ADP 9880vq3005s 6 15 increased increase VERB 9880vq3005s 6 16 branching branching NOUN 9880vq3005s 6 17 , , PUNCT 9880vq3005s 6 18 lack lack NOUN 9880vq3005s 6 19 of of ADP 9880vq3005s 6 20 organization organization NOUN 9880vq3005s 6 21 and and CCONJ 9880vq3005s 6 22 stunted stunt VERB 9880vq3005s 6 23 expansion expansion NOUN 9880vq3005s 6 24 of of ADP 9880vq3005s 6 25 the the DET 9880vq3005s 6 26 tree tree NOUN 9880vq3005s 6 27 into into ADP 9880vq3005s 6 28 the the DET 9880vq3005s 6 29 fat fat ADJ 9880vq3005s 6 30 pad pad NOUN 9880vq3005s 6 31 . . PUNCT 9880vq3005s 7 1 overexpression overexpression NOUN 9880vq3005s 7 2 of of ADP 9880vq3005s 7 3 p190b p190b ADV 9880vq3005s 7 4 during during ADP 9880vq3005s 7 5 pregnancy pregnancy NOUN 9880vq3005s 7 6 has have AUX 9880vq3005s 7 7 also also ADV 9880vq3005s 7 8 been be AUX 9880vq3005s 7 9 shown show VERB 9880vq3005s 7 10 to to PART 9880vq3005s 7 11 result result VERB 9880vq3005s 7 12 in in ADP 9880vq3005s 7 13 the the DET 9880vq3005s 7 14 development development NOUN 9880vq3005s 7 15 of of ADP 9880vq3005s 7 16 hyperplastic hyperplastic ADJ 9880vq3005s 7 17 lesions lesion NOUN 9880vq3005s 7 18 . . PUNCT 9880vq3005s 8 1 in in ADP 9880vq3005s 8 2 this this DET 9880vq3005s 8 3 project project NOUN 9880vq3005s 8 4 we we PRON 9880vq3005s 8 5 aim aim VERB 9880vq3005s 8 6 to to PART 9880vq3005s 8 7 determine determine VERB 9880vq3005s 8 8 the the DET 9880vq3005s 8 9 cellular cellular ADJ 9880vq3005s 8 10 and and CCONJ 9880vq3005s 8 11 molecular molecular ADJ 9880vq3005s 8 12 mechanisms mechanism NOUN 9880vq3005s 8 13 by by ADP 9880vq3005s 8 14 which which PRON 9880vq3005s 8 15 p190b p190b ADV 9880vq3005s 8 16 overexpression overexpression NOUN 9880vq3005s 8 17 disrupts disrupt VERB 9880vq3005s 8 18 mammary mammary ADJ 9880vq3005s 8 19 gland gland NOUN 9880vq3005s 8 20 development development NOUN 9880vq3005s 8 21 . . PUNCT 9880vq3005s 9 1 for for ADP 9880vq3005s 9 2 this this PRON 9880vq3005s 9 3 we we PRON 9880vq3005s 9 4 have have AUX 9880vq3005s 9 5 mimicked mimic VERB 9880vq3005s 9 6 mammary mammary ADJ 9880vq3005s 9 7 gland gland NOUN 9880vq3005s 9 8 ductal ductal PROPN 9880vq3005s 9 9 development development NOUN 9880vq3005s 9 10 using use VERB 9880vq3005s 9 11 a a DET 9880vq3005s 9 12 three three NUM 9880vq3005s 9 13 dimensional dimensional ADJ 9880vq3005s 9 14 culture culture NOUN 9880vq3005s 9 15 technique technique NOUN 9880vq3005s 9 16 . . PUNCT 9880vq3005s 10 1 primary primary ADJ 9880vq3005s 10 2 mammary mammary ADJ 9880vq3005s 10 3 epithelial epithelial ADJ 9880vq3005s 10 4 cells(mecs cells(mec NOUN 9880vq3005s 10 5 ) ) PUNCT 9880vq3005s 10 6 are be AUX 9880vq3005s 10 7 harvested harvest VERB 9880vq3005s 10 8 and and CCONJ 9880vq3005s 10 9 placed place VERB 9880vq3005s 10 10 in in ADP 9880vq3005s 10 11 single single ADJ 9880vq3005s 10 12 cell cell NOUN 9880vq3005s 10 13 suspension suspension NOUN 9880vq3005s 10 14 in in ADP 9880vq3005s 10 15 matrigel matrigel PROPN 9880vq3005s 10 16 reconstituted reconstituted PROPN 9880vq3005s 10 17 basement basement PROPN 9880vq3005s 10 18 membrane(rbm membrane(rbm PROPN 9880vq3005s 10 19 ) ) PUNCT 9880vq3005s 10 20 . . PUNCT 9880vq3005s 11 1 individual individual ADJ 9880vq3005s 11 2 cells cell NOUN 9880vq3005s 11 3 seeded seed VERB 9880vq3005s 11 4 in in ADP 9880vq3005s 11 5 matrigel matrigel PROPN 9880vq3005s 11 6 - - PUNCT 9880vq3005s 11 7 rbm rbm PROPN 9880vq3005s 11 8 form form NOUN 9880vq3005s 11 9 hollow hollow ADJ 9880vq3005s 11 10 acinus acinus NOUN 9880vq3005s 11 11 - - PUNCT 9880vq3005s 11 12 like like ADJ 9880vq3005s 11 13 colonies colony NOUN 9880vq3005s 11 14 of of ADP 9880vq3005s 11 15 cells cell NOUN 9880vq3005s 11 16 , , PUNCT 9880vq3005s 11 17 which which PRON 9880vq3005s 11 18 resemble resemble VERB 9880vq3005s 11 19 the the DET 9880vq3005s 11 20 natural natural ADJ 9880vq3005s 11 21 ductal ductal NOUN 9880vq3005s 11 22 structure structure NOUN 9880vq3005s 11 23 formed form VERB 9880vq3005s 11 24 in in ADP 9880vq3005s 11 25 vivo vivo NOUN 9880vq3005s 11 26 in in ADP 9880vq3005s 11 27 the the DET 9880vq3005s 11 28 mammary mammary ADJ 9880vq3005s 11 29 gland gland NOUN 9880vq3005s 11 30 . . PUNCT 9880vq3005s 12 1 primary primary ADJ 9880vq3005s 12 2 mecs mecs NOUN 9880vq3005s 12 3 are be AUX 9880vq3005s 12 4 obtained obtain VERB 9880vq3005s 12 5 from from ADP 9880vq3005s 12 6 tetracycline tetracycline NOUN 9880vq3005s 12 7 regulatable regulatable ADJ 9880vq3005s 12 8 p190b p190b PROPN 9880vq3005s 12 9 transgenic transgenic NOUN 9880vq3005s 12 10 mice mouse NOUN 9880vq3005s 12 11 . . PUNCT 9880vq3005s 13 1 the the DET 9880vq3005s 13 2 mecs mecs PROPN 9880vq3005s 13 3 harvested harvest VERB 9880vq3005s 13 4 from from ADP 9880vq3005s 13 5 these these DET 9880vq3005s 13 6 mice mouse NOUN 9880vq3005s 13 7 are be AUX 9880vq3005s 13 8 compared compare VERB 9880vq3005s 13 9 against against ADP 9880vq3005s 13 10 wild wild ADJ 9880vq3005s 13 11 type type NOUN 9880vq3005s 13 12 mice mouse NOUN 9880vq3005s 13 13 mecs mecs NOUN 9880vq3005s 13 14 in in ADP 9880vq3005s 13 15 the the DET 9880vq3005s 13 16 3d 3d NOUN 9880vq3005s 13 17 culture culture NOUN 9880vq3005s 13 18 . . PUNCT 9880vq3005s 14 1 using use VERB 9880vq3005s 14 2 this this DET 9880vq3005s 14 3 method method NOUN 9880vq3005s 14 4 it it PRON 9880vq3005s 14 5 was be AUX 9880vq3005s 14 6 determined determine VERB 9880vq3005s 14 7 that that SCONJ 9880vq3005s 14 8 p190b p190b ADV 9880vq3005s 14 9 overexpression overexpression NOUN 9880vq3005s 14 10 altered alter VERB 9880vq3005s 14 11 proliferation proliferation NOUN 9880vq3005s 14 12 , , PUNCT 9880vq3005s 14 13 polarity polarity NOUN 9880vq3005s 14 14 , , PUNCT 9880vq3005s 14 15 cell cell NOUN 9880vq3005s 14 16 death death NOUN 9880vq3005s 14 17 rates rate NOUN 9880vq3005s 14 18 and and CCONJ 9880vq3005s 14 19 morphology morphology NOUN 9880vq3005s 14 20 . . PUNCT