id sid tid token lemma pos 8g84mk63s3p 1 1 upregulation upregulation NOUN 8g84mk63s3p 1 2 of of ADP 8g84mk63s3p 1 3 the the DET 8g84mk63s3p 1 4 activated activate VERB 8g84mk63s3p 1 5 factor factor NOUN 8g84mk63s3p 1 6 vii vii NOUN 8g84mk63s3p 1 7 ( ( PUNCT 8g84mk63s3p 1 8 fviia)/tissue fviia)/tissue ADJ 8g84mk63s3p 1 9 factor factor NOUN 8g84mk63s3p 1 10 ( ( PUNCT 8g84mk63s3p 1 11 tf tf PROPN 8g84mk63s3p 1 12 ) ) PUNCT 8g84mk63s3p 1 13 complex complex NOUN 8g84mk63s3p 1 14 , , PUNCT 8g84mk63s3p 1 15 downregulation downregulation NOUN 8g84mk63s3p 1 16 of of ADP 8g84mk63s3p 1 17 natural natural ADJ 8g84mk63s3p 1 18 anticoagulation anticoagulation NOUN 8g84mk63s3p 1 19 pathways pathway NOUN 8g84mk63s3p 1 20 , , PUNCT 8g84mk63s3p 1 21 and and CCONJ 8g84mk63s3p 1 22 inhibition inhibition NOUN 8g84mk63s3p 1 23 of of ADP 8g84mk63s3p 1 24 fibrinolysis fibrinolysis NOUN 8g84mk63s3p 1 25 , , PUNCT 8g84mk63s3p 1 26 are be AUX 8g84mk63s3p 1 27 major major ADJ 8g84mk63s3p 1 28 contributors contributor NOUN 8g84mk63s3p 1 29 to to ADP 8g84mk63s3p 1 30 coagulopathies coagulopathie NOUN 8g84mk63s3p 1 31 associated associate VERB 8g84mk63s3p 1 32 with with ADP 8g84mk63s3p 1 33 acute acute ADJ 8g84mk63s3p 1 34 inflammation inflammation NOUN 8g84mk63s3p 1 35 . . PUNCT 8g84mk63s3p 2 1 provision provision NOUN 8g84mk63s3p 2 2 of of ADP 8g84mk63s3p 2 3 fviia fviia PROPN 8g84mk63s3p 2 4 , , PUNCT 8g84mk63s3p 2 5 and and CCONJ 8g84mk63s3p 2 6 consequent consequent ADJ 8g84mk63s3p 2 7 downstream downstream ADJ 8g84mk63s3p 2 8 coagulation coagulation NOUN 8g84mk63s3p 2 9 - - PUNCT 8g84mk63s3p 2 10 related relate VERB 8g84mk63s3p 2 11 proteases protease NOUN 8g84mk63s3p 2 12 , , PUNCT 8g84mk63s3p 2 13 also also ADV 8g84mk63s3p 2 14 stimulates stimulate VERB 8g84mk63s3p 2 15 further further ADJ 8g84mk63s3p 2 16 inflammatory inflammatory ADJ 8g84mk63s3p 2 17 changes change NOUN 8g84mk63s3p 2 18 . . PUNCT 8g84mk63s3p 3 1 thus thus ADV 8g84mk63s3p 3 2 , , PUNCT 8g84mk63s3p 3 3 the the DET 8g84mk63s3p 3 4 potential potential ADJ 8g84mk63s3p 3 5 protective protective ADJ 8g84mk63s3p 3 6 effects effect NOUN 8g84mk63s3p 3 7 in in ADP 8g84mk63s3p 3 8 vivo vivo NOUN 8g84mk63s3p 3 9 of of ADP 8g84mk63s3p 3 10 a a DET 8g84mk63s3p 3 11 genetic genetic ADJ 8g84mk63s3p 3 12 - - PUNCT 8g84mk63s3p 3 13 based base VERB 8g84mk63s3p 3 14 reduction reduction NOUN 8g84mk63s3p 3 15 in in ADP 8g84mk63s3p 3 16 fvii fvii ADJ 8g84mk63s3p 3 17 levels level NOUN 8g84mk63s3p 3 18 have have AUX 8g84mk63s3p 3 19 been be AUX 8g84mk63s3p 3 20 investigated investigate VERB 8g84mk63s3p 3 21 in in ADP 8g84mk63s3p 3 22 a a DET 8g84mk63s3p 3 23 murine murine NOUN 8g84mk63s3p 3 24 model model NOUN 8g84mk63s3p 3 25 of of ADP 8g84mk63s3p 3 26 acute acute ADJ 8g84mk63s3p 3 27 inflammation inflammation NOUN 8g84mk63s3p 3 28 , , PUNCT 8g84mk63s3p 3 29 viz viz PROPN 8g84mk63s3p 3 30 . . PROPN 8g84mk63s3p 3 31 , , PUNCT 8g84mk63s3p 3 32 lipopolysaccharide lipopolysaccharide PROPN 8g84mk63s3p 3 33 ( ( PUNCT 8g84mk63s3p 3 34 lps)-induced lps)-induce VERB 8g84mk63s3p 3 35 lethal lethal ADJ 8g84mk63s3p 3 36 endotoxemia endotoxemia NOUN 8g84mk63s3p 3 37 . . PUNCT 8g84mk63s3p 4 1 since since SCONJ 8g84mk63s3p 4 2 mice mouse NOUN 8g84mk63s3p 4 3 with with ADP 8g84mk63s3p 4 4 a a DET 8g84mk63s3p 4 5 total total ADJ 8g84mk63s3p 4 6 fvii fvii ADJ 8g84mk63s3p 4 7 deficiency deficiency NOUN 8g84mk63s3p 4 8 do do AUX 8g84mk63s3p 4 9 not not PART 8g84mk63s3p 4 10 survive survive VERB 8g84mk63s3p 4 11 the the DET 8g84mk63s3p 4 12 neonatal neonatal ADJ 8g84mk63s3p 4 13 period period NOUN 8g84mk63s3p 4 14 , , PUNCT 8g84mk63s3p 4 15 very very ADV 8g84mk63s3p 4 16 low low ADV 8g84mk63s3p 4 17 - - PUNCT 8g84mk63s3p 4 18 expressing express VERB 8g84mk63s3p 4 19 fvii fvii NOUN 8g84mk63s3p 4 20 ( ( PUNCT 8g84mk63s3p 4 21 fviitta fviitta PROPN 8g84mk63s3p 4 22 / / SYM 8g84mk63s3p 4 23 tta tta PROPN 8g84mk63s3p 4 24 ) ) PUNCT 8g84mk63s3p 4 25 mice mouse NOUN 8g84mk63s3p 4 26 , , PUNCT 8g84mk63s3p 4 27 producing produce VERB 8g84mk63s3p 4 28 sufficient sufficient ADJ 8g84mk63s3p 4 29 amounts amount NOUN 8g84mk63s3p 4 30 of of ADP 8g84mk63s3p 4 31 fvii fvii PROPN 8g84mk63s3p 4 32 for for ADP 8g84mk63s3p 4 33 survival survival NOUN 8g84mk63s3p 4 34 ( ( PUNCT 8g84mk63s3p 4 35 ca can AUX 8g84mk63s3p 4 36 . . PROPN 8g84mk63s3p 4 37 , , PUNCT 8g84mk63s3p 4 38 1 1 NUM 8g84mk63s3p 4 39 % % NOUN 8g84mk63s3p 4 40 of of ADP 8g84mk63s3p 4 41 wt wt PROPN 8g84mk63s3p 4 42 fvii fvii PROPN 8g84mk63s3p 4 43 ) ) PUNCT 8g84mk63s3p 4 44 , , PUNCT 8g84mk63s3p 4 45 were be AUX 8g84mk63s3p 4 46 employed employ VERB 8g84mk63s3p 4 47 to to PART 8g84mk63s3p 4 48 investigate investigate VERB 8g84mk63s3p 4 49 in in ADP 8g84mk63s3p 4 50 vivo vivo ADJ 8g84mk63s3p 4 51 pathways pathway NOUN 8g84mk63s3p 4 52 involved involve VERB 8g84mk63s3p 4 53 in in ADP 8g84mk63s3p 4 54 the the DET 8g84mk63s3p 4 55 crosstalk crosstalk NOUN 8g84mk63s3p 4 56 between between ADP 8g84mk63s3p 4 57 coagulation coagulation NOUN 8g84mk63s3p 4 58 , , PUNCT 8g84mk63s3p 4 59 inflammation inflammation NOUN 8g84mk63s3p 4 60 , , PUNCT 8g84mk63s3p 4 61 and and CCONJ 8g84mk63s3p 4 62 survival survival NOUN 8g84mk63s3p 4 63 , , PUNCT 8g84mk63s3p 4 64 consequent consequent ADJ 8g84mk63s3p 4 65 to to ADP 8g84mk63s3p 4 66 administration administration NOUN 8g84mk63s3p 4 67 of of ADP 8g84mk63s3p 4 68 a a DET 8g84mk63s3p 4 69 lethal lethal ADJ 8g84mk63s3p 4 70 dose dose NOUN 8g84mk63s3p 4 71 of of ADP 8g84mk63s3p 4 72 lps lps PROPN 8g84mk63s3p 4 73 . . PUNCT 8g84mk63s3p 5 1 the the DET 8g84mk63s3p 5 2 fviitta fviitta PROPN 8g84mk63s3p 5 3 / / SYM 8g84mk63s3p 5 4 tta tta PROPN 8g84mk63s3p 5 5 mice mouse NOUN 8g84mk63s3p 5 6 presented present VERB 8g84mk63s3p 5 7 with with ADP 8g84mk63s3p 5 8 reduced reduce VERB 8g84mk63s3p 5 9 mortality mortality NOUN 8g84mk63s3p 5 10 , , PUNCT 8g84mk63s3p 5 11 coagulation coagulation NOUN 8g84mk63s3p 5 12 , , PUNCT 8g84mk63s3p 5 13 and and CCONJ 8g84mk63s3p 5 14 inflammatory inflammatory ADJ 8g84mk63s3p 5 15 responses response NOUN 8g84mk63s3p 5 16 when when SCONJ 8g84mk63s3p 5 17 compared compare VERB 8g84mk63s3p 5 18 to to ADP 8g84mk63s3p 5 19 similarly similarly ADV 8g84mk63s3p 5 20 - - PUNCT 8g84mk63s3p 5 21 treated treat VERB 8g84mk63s3p 5 22 wild wild ADJ 8g84mk63s3p 5 23 - - PUNCT 8g84mk63s3p 5 24 type type NOUN 8g84mk63s3p 5 25 ( ( PUNCT 8g84mk63s3p 5 26 wt wt NOUN 8g84mk63s3p 5 27 ) ) PUNCT 8g84mk63s3p 5 28 mice mouse NOUN 8g84mk63s3p 5 29 after after ADP 8g84mk63s3p 5 30 administration administration NOUN 8g84mk63s3p 5 31 of of ADP 8g84mk63s3p 5 32 lps lps PROPN 8g84mk63s3p 5 33 . . PUNCT 8g84mk63s3p 6 1 the the DET 8g84mk63s3p 6 2 attenuated attenuated ADJ 8g84mk63s3p 6 3 inflammatory inflammatory ADJ 8g84mk63s3p 6 4 responses response NOUN 8g84mk63s3p 6 5 in in ADP 8g84mk63s3p 6 6 fviitta fviitta PROPN 8g84mk63s3p 6 7 / / SYM 8g84mk63s3p 6 8 tta tta PROPN 8g84mk63s3p 6 9 mice mouse NOUN 8g84mk63s3p 6 10 were be AUX 8g84mk63s3p 6 11 associated associate VERB 8g84mk63s3p 6 12 with with ADP 8g84mk63s3p 6 13 downregulation downregulation NOUN 8g84mk63s3p 6 14 of of ADP 8g84mk63s3p 6 15 egr-1 egr-1 PRON 8g84mk63s3p 6 16 signaling signaling NOUN 8g84mk63s3p 6 17 . . PUNCT 8g84mk63s3p 7 1 administration administration PROPN 8g84mk63s3p 7 2 , , PUNCT 8g84mk63s3p 7 3 in in ADP 8g84mk63s3p 7 4 vivo vivo PROPN 8g84mk63s3p 7 5 , , PUNCT 8g84mk63s3p 7 6 of of ADP 8g84mk63s3p 7 7 specific specific ADJ 8g84mk63s3p 7 8 inhibitors inhibitor NOUN 8g84mk63s3p 7 9 of of ADP 8g84mk63s3p 7 10 fxa fxa NOUN 8g84mk63s3p 7 11 and and CCONJ 8g84mk63s3p 7 12 thrombin thrombin NOUN 8g84mk63s3p 7 13 demonstrated demonstrate VERB 8g84mk63s3p 7 14 that that SCONJ 8g84mk63s3p 7 15 the the DET 8g84mk63s3p 7 16 inflammatory inflammatory ADJ 8g84mk63s3p 7 17 responses response NOUN 8g84mk63s3p 7 18 were be AUX 8g84mk63s3p 7 19 unaltered unaltere VERB 8g84mk63s3p 7 20 in in ADP 8g84mk63s3p 7 21 wt wt PROPN 8g84mk63s3p 7 22 mice mouse NOUN 8g84mk63s3p 7 23 , , PUNCT 8g84mk63s3p 7 24 but but CCONJ 8g84mk63s3p 7 25 further far ADV 8g84mk63s3p 7 26 reduced reduce VERB 8g84mk63s3p 7 27 in in ADP 8g84mk63s3p 7 28 fviitta fviitta PROPN 8g84mk63s3p 7 29 / / SYM 8g84mk63s3p 7 30 tta tta PROPN 8g84mk63s3p 7 31 mice mouse NOUN 8g84mk63s3p 7 32 . . PUNCT 8g84mk63s3p 8 1 therefore therefore ADV 8g84mk63s3p 8 2 , , PUNCT 8g84mk63s3p 8 3 a a DET 8g84mk63s3p 8 4 fvii fvii ADJ 8g84mk63s3p 8 5 deficiency deficiency NOUN 8g84mk63s3p 8 6 enhances enhance VERB 8g84mk63s3p 8 7 survival survival NOUN 8g84mk63s3p 8 8 from from ADP 8g84mk63s3p 8 9 lethal lethal ADJ 8g84mk63s3p 8 10 endotoxemia endotoxemia NOUN 8g84mk63s3p 8 11 both both CCONJ 8g84mk63s3p 8 12 through through ADP 8g84mk63s3p 8 13 attenuation attenuation NOUN 8g84mk63s3p 8 14 of of ADP 8g84mk63s3p 8 15 inflammatory inflammatory ADJ 8g84mk63s3p 8 16 responses response NOUN 8g84mk63s3p 8 17 that that PRON 8g84mk63s3p 8 18 result result VERB 8g84mk63s3p 8 19 directly directly ADV 8g84mk63s3p 8 20 from from ADP 8g84mk63s3p 8 21 reduced reduce VERB 8g84mk63s3p 8 22 fviia fviia ADJ 8g84mk63s3p 8 23 levels level NOUN 8g84mk63s3p 8 24 , , PUNCT 8g84mk63s3p 8 25 and and CCONJ 8g84mk63s3p 8 26 , , PUNCT 8g84mk63s3p 8 27 indirectly indirectly ADV 8g84mk63s3p 8 28 , , PUNCT 8g84mk63s3p 8 29 from from ADP 8g84mk63s3p 8 30 downregulation downregulation NOUN 8g84mk63s3p 8 31 of of ADP 8g84mk63s3p 8 32 coagulation coagulation NOUN 8g84mk63s3p 8 33 proteases protease NOUN 8g84mk63s3p 8 34 downstream downstream ADV 8g84mk63s3p 8 35 of of ADP 8g84mk63s3p 8 36 the the DET 8g84mk63s3p 8 37 fvii fvii ADJ 8g84mk63s3p 8 38 - - PUNCT 8g84mk63s3p 8 39 dependent dependent ADJ 8g84mk63s3p 8 40 cascade cascade NOUN 8g84mk63s3p 8 41 . . PUNCT 8g84mk63s3p 9 1 keratinocytes keratinocyte NOUN 8g84mk63s3p 9 2 from from ADP 8g84mk63s3p 9 3 skin skin NOUN 8g84mk63s3p 9 4 tissue tissue NOUN 8g84mk63s3p 9 5 are be AUX 8g84mk63s3p 9 6 rich rich ADJ 8g84mk63s3p 9 7 sources source NOUN 8g84mk63s3p 9 8 of of ADP 8g84mk63s3p 9 9 tissue tissue NOUN 8g84mk63s3p 9 10 factor factor NOUN 8g84mk63s3p 9 11 and and CCONJ 8g84mk63s3p 9 12 are be AUX 8g84mk63s3p 9 13 highly highly ADV 8g84mk63s3p 9 14 associated associate VERB 8g84mk63s3p 9 15 with with ADP 8g84mk63s3p 9 16 skin skin NOUN 8g84mk63s3p 9 17 wound wound NOUN 8g84mk63s3p 9 18 healing healing NOUN 8g84mk63s3p 9 19 . . PUNCT 8g84mk63s3p 10 1 however however ADV 8g84mk63s3p 10 2 , , PUNCT 8g84mk63s3p 10 3 studies study NOUN 8g84mk63s3p 10 4 of of ADP 8g84mk63s3p 10 5 the the DET 8g84mk63s3p 10 6 involvement involvement NOUN 8g84mk63s3p 10 7 of of ADP 8g84mk63s3p 10 8 extrinsic extrinsic ADJ 8g84mk63s3p 10 9 coagulation coagulation NOUN 8g84mk63s3p 10 10 factors factor NOUN 8g84mk63s3p 10 11 during during ADP 8g84mk63s3p 10 12 skin skin NOUN 8g84mk63s3p 10 13 wound wound NOUN 8g84mk63s3p 10 14 healing healing NOUN 8g84mk63s3p 10 15 are be AUX 8g84mk63s3p 10 16 still still ADV 8g84mk63s3p 10 17 lacking lack VERB 8g84mk63s3p 10 18 . . PUNCT 8g84mk63s3p 11 1 here here ADV 8g84mk63s3p 11 2 we we PRON 8g84mk63s3p 11 3 demonstrated demonstrate VERB 8g84mk63s3p 11 4 that that SCONJ 8g84mk63s3p 11 5 low low ADJ 8g84mk63s3p 11 6 fvii fvii ADJ 8g84mk63s3p 11 7 mice mouse NOUN 8g84mk63s3p 11 8 exhibited exhibit VERB 8g84mk63s3p 11 9 impaired impair VERB 8g84mk63s3p 11 10 skin skin NOUN 8g84mk63s3p 11 11 wound wound NOUN 8g84mk63s3p 11 12 healing healing NOUN 8g84mk63s3p 11 13 . . PUNCT 8g84mk63s3p 12 1 these these DET 8g84mk63s3p 12 2 gene gene NOUN 8g84mk63s3p 12 3 - - PUNCT 8g84mk63s3p 12 4 deficiency deficiency NOUN 8g84mk63s3p 12 5 mice mouse NOUN 8g84mk63s3p 12 6 showed show VERB 8g84mk63s3p 12 7 delayed delay VERB 8g84mk63s3p 12 8 re re NOUN 8g84mk63s3p 12 9 - - NOUN 8g84mk63s3p 12 10 epithelialization epithelialization NOUN 8g84mk63s3p 12 11 and and CCONJ 8g84mk63s3p 12 12 reduced reduce VERB 8g84mk63s3p 12 13 inflammatory inflammatory ADJ 8g84mk63s3p 12 14 cell cell NOUN 8g84mk63s3p 12 15 infiltration infiltration NOUN 8g84mk63s3p 12 16 at at ADP 8g84mk63s3p 12 17 wound wound NOUN 8g84mk63s3p 12 18 sites site NOUN 8g84mk63s3p 12 19 compared compare VERB 8g84mk63s3p 12 20 with with ADP 8g84mk63s3p 12 21 control control NOUN 8g84mk63s3p 12 22 mice mouse NOUN 8g84mk63s3p 12 23 . . PUNCT 8g84mk63s3p 13 1 the the DET 8g84mk63s3p 13 2 reduced reduced ADJ 8g84mk63s3p 13 3 inflammatory inflammatory ADJ 8g84mk63s3p 13 4 response response NOUN 8g84mk63s3p 13 5 in in ADP 8g84mk63s3p 13 6 low low ADJ 8g84mk63s3p 13 7 fvii fvii ADJ 8g84mk63s3p 13 8 mice mouse NOUN 8g84mk63s3p 13 9 was be AUX 8g84mk63s3p 13 10 also also ADV 8g84mk63s3p 13 11 demonstrated demonstrate VERB 8g84mk63s3p 13 12 using use VERB 8g84mk63s3p 13 13 a a DET 8g84mk63s3p 13 14 thioglycollate thioglycollate ADJ 8g84mk63s3p 13 15 induced induce VERB 8g84mk63s3p 13 16 inflammatory inflammatory ADJ 8g84mk63s3p 13 17 model model NOUN 8g84mk63s3p 13 18 . . PUNCT 8g84mk63s3p 14 1 the the DET 8g84mk63s3p 14 2 delayed delayed ADJ 8g84mk63s3p 14 3 re re NOUN 8g84mk63s3p 14 4 - - NOUN 8g84mk63s3p 14 5 epthelialization epthelialization ADJ 8g84mk63s3p 14 6 in in ADP 8g84mk63s3p 14 7 low low ADJ 8g84mk63s3p 14 8 fvii fvii ADJ 8g84mk63s3p 14 9 mice mouse NOUN 8g84mk63s3p 14 10 was be AUX 8g84mk63s3p 14 11 associated associate VERB 8g84mk63s3p 14 12 with with ADP 8g84mk63s3p 14 13 regulation regulation NOUN 8g84mk63s3p 14 14 of of ADP 8g84mk63s3p 14 15 egr-1 egr-1 PRON 8g84mk63s3p 14 16 as as ADV 8g84mk63s3p 14 17 demonstrated demonstrate VERB 8g84mk63s3p 14 18 by by ADP 8g84mk63s3p 14 19 the the DET 8g84mk63s3p 14 20 increased increase VERB 8g84mk63s3p 14 21 expression expression NOUN 8g84mk63s3p 14 22 level level NOUN 8g84mk63s3p 14 23 of of ADP 8g84mk63s3p 14 24 egr-1 egr-1 ADP 8g84mk63s3p 14 25 by by ADP 8g84mk63s3p 14 26 fviia fviia ADJ 8g84mk63s3p 14 27 stimulation stimulation NOUN 8g84mk63s3p 14 28 in in ADP 8g84mk63s3p 14 29 keratinocytes keratinocyte NOUN 8g84mk63s3p 14 30 . . PUNCT 8g84mk63s3p 15 1 in in ADP 8g84mk63s3p 15 2 vitro vitro X 8g84mk63s3p 15 3 , , PUNCT 8g84mk63s3p 15 4 egr-1 egr-1 AUX 8g84mk63s3p 15 5 was be AUX 8g84mk63s3p 15 6 shown show VERB 8g84mk63s3p 15 7 to to PART 8g84mk63s3p 15 8 be be AUX 8g84mk63s3p 15 9 essential essential ADJ 8g84mk63s3p 15 10 for for ADP 8g84mk63s3p 15 11 fviia fviia ADJ 8g84mk63s3p 15 12 induced induce VERB 8g84mk63s3p 15 13 keratinocytes keratinocyte NOUN 8g84mk63s3p 15 14 migration migration NOUN 8g84mk63s3p 15 15 and and CCONJ 8g84mk63s3p 15 16 inflammation inflammation NOUN 8g84mk63s3p 15 17 . . PUNCT 8g84mk63s3p 16 1 in in ADP 8g84mk63s3p 16 2 vivo vivo PROPN 8g84mk63s3p 16 3 , , PUNCT 8g84mk63s3p 16 4 egr-1 egr-1 CCONJ 8g84mk63s3p 16 5 deficient deficient ADJ 8g84mk63s3p 16 6 mice mouse NOUN 8g84mk63s3p 16 7 displayed display VERB 8g84mk63s3p 16 8 a a DET 8g84mk63s3p 16 9 significant significant ADJ 8g84mk63s3p 16 10 delay delay NOUN 8g84mk63s3p 16 11 of of ADP 8g84mk63s3p 16 12 skin skin NOUN 8g84mk63s3p 16 13 wound wound NOUN 8g84mk63s3p 16 14 healing healing NOUN 8g84mk63s3p 16 15 . . PUNCT