id	sid	tid	token	lemma	pos
8c97kp81j4j	1	1	polyketide	polyketide	PROPN
8c97kp81j4j	1	2	natural	natural	ADJ
8c97kp81j4j	1	3	products	product	NOUN
8c97kp81j4j	1	4	have	have	AUX
8c97kp81j4j	1	5	classically	classically	ADV
8c97kp81j4j	1	6	captured	capture	VERB
8c97kp81j4j	1	7	the	the	DET
8c97kp81j4j	1	8	attention	attention	NOUN
8c97kp81j4j	1	9	of	of	ADP
8c97kp81j4j	1	10	the	the	DET
8c97kp81j4j	1	11	organic	organic	ADJ
8c97kp81j4j	1	12	and	and	CCONJ
8c97kp81j4j	1	13	medicinal	medicinal	ADJ
8c97kp81j4j	1	14	chemical	chemical	NOUN
8c97kp81j4j	1	15	community	community	NOUN
8c97kp81j4j	1	16	owing	owe	VERB
8c97kp81j4j	1	17	to	to	ADP
8c97kp81j4j	1	18	their	their	PRON
8c97kp81j4j	1	19	intricate	intricate	ADJ
8c97kp81j4j	1	20	structural	structural	ADJ
8c97kp81j4j	1	21	architecture	architecture	NOUN
8c97kp81j4j	1	22	and	and	CCONJ
8c97kp81j4j	1	23	their	their	PRON
8c97kp81j4j	1	24	powerful	powerful	ADJ
8c97kp81j4j	1	25	biological	biological	ADJ
8c97kp81j4j	1	26	properties	property	NOUN
8c97kp81j4j	1	27	.	.	PUNCT
8c97kp81j4j	2	1	polyketides	polyketide	NOUN
8c97kp81j4j	2	2	are	be	AUX
8c97kp81j4j	2	3	biosynthetically	biosynthetically	ADV
8c97kp81j4j	2	4	constructed	construct	VERB
8c97kp81j4j	2	5	on	on	ADP
8c97kp81j4j	2	6	an	an	DET
8c97kp81j4j	2	7	enzymatic	enzymatic	ADJ
8c97kp81j4j	2	8	assembly	assembly	NOUN
8c97kp81j4j	2	9	line	line	NOUN
8c97kp81j4j	2	10	through	through	ADP
8c97kp81j4j	2	11	sequential	sequential	ADJ
8c97kp81j4j	2	12	claisen	claisen	PROPN
8c97kp81j4j	2	13	condensations	condensation	NOUN
8c97kp81j4j	2	14	with	with	ADP
8c97kp81j4j	2	15	malonyl	malonyl	NOUN
8c97kp81j4j	2	16	-	-	PUNCT
8c97kp81j4j	2	17	coa	coa	NOUN
8c97kp81j4j	2	18	and	and	CCONJ
8c97kp81j4j	2	19	methylmalonyl	methylmalonyl	NOUN
8c97kp81j4j	2	20	-	-	PUNCT
8c97kp81j4j	2	21	coa	coa	NOUN
8c97kp81j4j	2	22	to	to	PART
8c97kp81j4j	2	23	build	build	VERB
8c97kp81j4j	2	24	the	the	DET
8c97kp81j4j	2	25	carbon	carbon	NOUN
8c97kp81j4j	2	26	scaffold	scaffold	NOUN
8c97kp81j4j	2	27	.	.	PUNCT
8c97kp81j4j	3	1	accessory	accessory	NOUN
8c97kp81j4j	3	2	domains	domain	NOUN
8c97kp81j4j	3	3	and	and	CCONJ
8c97kp81j4j	3	4	oxidative	oxidative	ADJ
8c97kp81j4j	3	5	tailoring	tailor	VERB
8c97kp81j4j	3	6	events	event	NOUN
8c97kp81j4j	3	7	in	in	ADP
8c97kp81j4j	3	8	the	the	DET
8c97kp81j4j	3	9	enzymatic	enzymatic	ADJ
8c97kp81j4j	3	10	machinery	machinery	NOUN
8c97kp81j4j	3	11	install	install	VERB
8c97kp81j4j	3	12	the	the	DET
8c97kp81j4j	3	13	intricate	intricate	ADJ
8c97kp81j4j	3	14	oxidative	oxidative	ADJ
8c97kp81j4j	3	15	and	and	CCONJ
8c97kp81j4j	3	16	stereochemical	stereochemical	ADJ
8c97kp81j4j	3	17	elements	element	NOUN
8c97kp81j4j	3	18	that	that	PRON
8c97kp81j4j	3	19	are	be	AUX
8c97kp81j4j	3	20	often	often	ADV
8c97kp81j4j	3	21	associated	associate	VERB
8c97kp81j4j	3	22	with	with	ADP
8c97kp81j4j	3	23	a	a	DET
8c97kp81j4j	3	24	compound	compound	NOUN
8c97kp81j4j	3	25	's	's	PART
8c97kp81j4j	3	26	potent	potent	ADJ
8c97kp81j4j	3	27	biological	biological	ADJ
8c97kp81j4j	3	28	activities	activity	NOUN
8c97kp81j4j	3	29	.	.	PUNCT
8c97kp81j4j	4	1	the	the	DET
8c97kp81j4j	4	2	intrinsic	intrinsic	ADJ
8c97kp81j4j	4	3	stereochemical	stereochemical	ADJ
8c97kp81j4j	4	4	elements	element	NOUN
8c97kp81j4j	4	5	decorating	decorate	VERB
8c97kp81j4j	4	6	the	the	DET
8c97kp81j4j	4	7	polyketide	polyketide	NOUN
8c97kp81j4j	4	8	backbone	backbone	PROPN
8c97kp81j4j	4	9	force	force	PROPN
8c97kp81j4j	4	10	the	the	DET
8c97kp81j4j	4	11	molecule	molecule	NOUN
8c97kp81j4j	4	12	to	to	PART
8c97kp81j4j	4	13	preferentially	preferentially	ADV
8c97kp81j4j	4	14	adopt	adopt	VERB
8c97kp81j4j	4	15	specific	specific	ADJ
8c97kp81j4j	4	16	conformational	conformational	ADJ
8c97kp81j4j	4	17	preferences	preference	NOUN
8c97kp81j4j	4	18	,	,	PUNCT
8c97kp81j4j	4	19	in	in	ADP
8c97kp81j4j	4	20	which	which	PRON
8c97kp81j4j	4	21	hoffmann	hoffmann	PROPN
8c97kp81j4j	4	22	aptly	aptly	ADV
8c97kp81j4j	4	23	described	describe	VERB
8c97kp81j4j	4	24	as	as	ADP
8c97kp81j4j	4	25	"	"	PUNCT
8c97kp81j4j	4	26	flexible	flexible	ADJ
8c97kp81j4j	4	27	molecules	molecule	NOUN
8c97kp81j4j	4	28	with	with	ADP
8c97kp81j4j	4	29	a	a	DET
8c97kp81j4j	4	30	defined	define	VERB
8c97kp81j4j	4	31	shape	shape	NOUN
8c97kp81j4j	4	32	.	.	PUNCT
8c97kp81j4j	5	1	"this	"this	PRON
8c97kp81j4j	5	2	thesis	thesis	NOUN
8c97kp81j4j	5	3	aims	aim	VERB
8c97kp81j4j	5	4	to	to	PART
8c97kp81j4j	5	5	describe	describe	VERB
8c97kp81j4j	5	6	the	the	DET
8c97kp81j4j	5	7	relationship	relationship	NOUN
8c97kp81j4j	5	8	between	between	ADP
8c97kp81j4j	5	9	the	the	DET
8c97kp81j4j	5	10	conformational	conformational	ADJ
8c97kp81j4j	5	11	preferences	preference	NOUN
8c97kp81j4j	5	12	and	and	CCONJ
8c97kp81j4j	5	13	biological	biological	ADJ
8c97kp81j4j	5	14	properties	property	NOUN
8c97kp81j4j	5	15	of	of	ADP
8c97kp81j4j	5	16	the	the	DET
8c97kp81j4j	5	17	polyketide	polyketide	NOUN
8c97kp81j4j	5	18	natural	natural	ADJ
8c97kp81j4j	5	19	products	product	NOUN
8c97kp81j4j	5	20	,	,	PUNCT
8c97kp81j4j	5	21	zampanolide	zampanolide	PROPN
8c97kp81j4j	5	22	,	,	PUNCT
8c97kp81j4j	5	23	dactylolide	dactylolide	PROPN
8c97kp81j4j	5	24	and	and	CCONJ
8c97kp81j4j	5	25	gex1a	gex1a	PROPN
8c97kp81j4j	5	26	.	.	PROPN
8c97kp81j4j	6	1	to	to	PART
8c97kp81j4j	6	2	do	do	VERB
8c97kp81j4j	6	3	so	so	ADV
8c97kp81j4j	6	4	,	,	PUNCT
8c97kp81j4j	6	5	our	our	PRON
8c97kp81j4j	6	6	laboratory	laboratory	NOUN
8c97kp81j4j	6	7	has	have	AUX
8c97kp81j4j	6	8	employed	employ	VERB
8c97kp81j4j	6	9	a	a	DET
8c97kp81j4j	6	10	combination	combination	NOUN
8c97kp81j4j	6	11	of	of	ADP
8c97kp81j4j	6	12	chemical	chemical	ADJ
8c97kp81j4j	6	13	and	and	CCONJ
8c97kp81j4j	6	14	biological	biological	ADJ
8c97kp81j4j	6	15	synthesis	synthesis	NOUN
8c97kp81j4j	6	16	,	,	PUNCT
8c97kp81j4j	6	17	computational	computational	ADJ
8c97kp81j4j	6	18	,	,	PUNCT
8c97kp81j4j	6	19	1d	1d	NOUN
8c97kp81j4j	6	20	and	and	CCONJ
8c97kp81j4j	6	21	2d	2d	PROPN
8c97kp81j4j	6	22	solutional	solutional	ADJ
8c97kp81j4j	6	23	nmr	nmr	NOUN
8c97kp81j4j	6	24	studies	study	NOUN
8c97kp81j4j	6	25	and	and	CCONJ
8c97kp81j4j	6	26	biological	biological	ADJ
8c97kp81j4j	6	27	assays	assay	NOUN
8c97kp81j4j	6	28	to	to	PART
8c97kp81j4j	6	29	describe	describe	VERB
8c97kp81j4j	6	30	this	this	DET
8c97kp81j4j	6	31	relationship	relationship	NOUN
8c97kp81j4j	6	32	.	.	PUNCT
8c97kp81j4j	7	1	the	the	DET
8c97kp81j4j	7	2	characterization	characterization	NOUN
8c97kp81j4j	7	3	of	of	ADP
8c97kp81j4j	7	4	these	these	DET
8c97kp81j4j	7	5	relationships	relationship	NOUN
8c97kp81j4j	7	6	represents	represent	VERB
8c97kp81j4j	7	7	an	an	DET
8c97kp81j4j	7	8	innovative	innovative	ADJ
8c97kp81j4j	7	9	approach	approach	NOUN
8c97kp81j4j	7	10	to	to	ADP
8c97kp81j4j	7	11	rational	rational	ADJ
8c97kp81j4j	7	12	design	design	NOUN
8c97kp81j4j	7	13	to	to	PART
8c97kp81j4j	7	14	identify	identify	VERB
8c97kp81j4j	7	15	novel	novel	ADJ
8c97kp81j4j	7	16	active	active	ADJ
8c97kp81j4j	7	17	analogues	analogue	NOUN
8c97kp81j4j	7	18	of	of	ADP
8c97kp81j4j	7	19	natural	natural	ADJ
8c97kp81j4j	7	20	products	product	NOUN
8c97kp81j4j	7	21	that	that	PRON
8c97kp81j4j	7	22	may	may	AUX
8c97kp81j4j	7	23	be	be	AUX
8c97kp81j4j	7	24	further	far	ADV
8c97kp81j4j	7	25	studied	study	VERB
8c97kp81j4j	7	26	for	for	ADP
8c97kp81j4j	7	27	their	their	PRON
8c97kp81j4j	7	28	therapeutic	therapeutic	ADJ
8c97kp81j4j	7	29	potential.the	potential.the	DET
8c97kp81j4j	7	30	first	first	ADJ
8c97kp81j4j	7	31	two	two	NUM
8c97kp81j4j	7	32	chapters	chapter	NOUN
8c97kp81j4j	7	33	of	of	ADP
8c97kp81j4j	7	34	this	this	DET
8c97kp81j4j	7	35	thesis	thesis	NOUN
8c97kp81j4j	7	36	provide	provide	VERB
8c97kp81j4j	7	37	the	the	DET
8c97kp81j4j	7	38	background	background	NOUN
8c97kp81j4j	7	39	and	and	CCONJ
8c97kp81j4j	7	40	report	report	VERB
8c97kp81j4j	7	41	our	our	PRON
8c97kp81j4j	7	42	studies	study	NOUN
8c97kp81j4j	7	43	involving	involve	VERB
8c97kp81j4j	7	44	the	the	DET
8c97kp81j4j	7	45	covalent	covalent	NOUN
8c97kp81j4j	7	46	microtubule	microtubule	NOUN
8c97kp81j4j	7	47	stabilizing	stabilize	VERB
8c97kp81j4j	7	48	agents	agent	NOUN
8c97kp81j4j	7	49	,	,	PUNCT
8c97kp81j4j	7	50	zampanolide	zampanolide	NOUN
8c97kp81j4j	7	51	and	and	CCONJ
8c97kp81j4j	7	52	dactylolide	dactylolide	PROPN
8c97kp81j4j	7	53	.	.	PUNCT
8c97kp81j4j	8	1	the	the	DET
8c97kp81j4j	8	2	compounds	compound	NOUN
8c97kp81j4j	8	3	represent	represent	VERB
8c97kp81j4j	8	4	viable	viable	ADJ
8c97kp81j4j	8	5	therapeutics	therapeutic	NOUN
8c97kp81j4j	8	6	for	for	ADP
8c97kp81j4j	8	7	the	the	DET
8c97kp81j4j	8	8	treatment	treatment	NOUN
8c97kp81j4j	8	9	of	of	ADP
8c97kp81j4j	8	10	multi	multi	ADJ
8c97kp81j4j	8	11	-	-	ADJ
8c97kp81j4j	8	12	drug	drug	ADJ
8c97kp81j4j	8	13	resistant	resistant	ADJ
8c97kp81j4j	8	14	cancer	cancer	NOUN
8c97kp81j4j	8	15	.	.	PUNCT
8c97kp81j4j	9	1	previously	previously	ADV
8c97kp81j4j	9	2	,	,	PUNCT
8c97kp81j4j	9	3	our	our	PRON
8c97kp81j4j	9	4	lab	lab	NOUN
8c97kp81j4j	9	5	completed	complete	VERB
8c97kp81j4j	9	6	a	a	DET
8c97kp81j4j	9	7	total	total	ADJ
8c97kp81j4j	9	8	synthesis	synthesis	NOUN
8c97kp81j4j	9	9	of	of	ADP
8c97kp81j4j	9	10	both	both	PRON
8c97kp81j4j	9	11	of	of	ADP
8c97kp81j4j	9	12	the	the	DET
8c97kp81j4j	9	13	macrolides	macrolide	NOUN
8c97kp81j4j	9	14	and	and	CCONJ
8c97kp81j4j	9	15	described	describe	VERB
8c97kp81j4j	9	16	their	their	PRON
8c97kp81j4j	9	17	low	low	ADJ
8c97kp81j4j	9	18	energy	energy	NOUN
8c97kp81j4j	9	19	conformational	conformational	ADJ
8c97kp81j4j	9	20	preferences	preference	NOUN
8c97kp81j4j	9	21	of	of	ADP
8c97kp81j4j	9	22	the	the	DET
8c97kp81j4j	9	23	macrolactone	macrolactone	NOUN
8c97kp81j4j	9	24	ring	ring	NOUN
8c97kp81j4j	9	25	.	.	PUNCT
8c97kp81j4j	10	1	with	with	ADP
8c97kp81j4j	10	2	this	this	DET
8c97kp81j4j	10	3	analysis	analysis	NOUN
8c97kp81j4j	10	4	,	,	PUNCT
8c97kp81j4j	10	5	our	our	PRON
8c97kp81j4j	10	6	lab	lab	NOUN
8c97kp81j4j	10	7	identified	identify	VERB
8c97kp81j4j	10	8	a	a	DET
8c97kp81j4j	10	9	degree	degree	NOUN
8c97kp81j4j	10	10	of	of	ADP
8c97kp81j4j	10	11	rigidity	rigidity	NOUN
8c97kp81j4j	10	12	about	about	ADP
8c97kp81j4j	10	13	the	the	DET
8c97kp81j4j	10	14	southwestern	southwestern	ADJ
8c97kp81j4j	10	15	region	region	NOUN
8c97kp81j4j	10	16	of	of	ADP
8c97kp81j4j	10	17	the	the	DET
8c97kp81j4j	10	18	macrolide	macrolide	NOUN
8c97kp81j4j	10	19	.	.	PUNCT
8c97kp81j4j	11	1	this	this	DET
8c97kp81j4j	11	2	rigidity	rigidity	NOUN
8c97kp81j4j	11	3	is	be	AUX
8c97kp81j4j	11	4	associated	associate	VERB
8c97kp81j4j	11	5	with	with	ADP
8c97kp81j4j	11	6	the	the	DET
8c97kp81j4j	11	7	allylic	allylic	ADJ
8c97kp81j4j	11	8	strain	strain	NOUN
8c97kp81j4j	11	9	about	about	ADP
8c97kp81j4j	11	10	the	the	DET
8c97kp81j4j	11	11	trisubstituted	trisubstitute	VERB
8c97kp81j4j	11	12	olefin	olefin	NOUN
8c97kp81j4j	11	13	.	.	PUNCT
8c97kp81j4j	12	1	to	to	PART
8c97kp81j4j	12	2	probe	probe	VERB
8c97kp81j4j	12	3	the	the	DET
8c97kp81j4j	12	4	role	role	NOUN
8c97kp81j4j	12	5	the	the	DET
8c97kp81j4j	12	6	c17	c17	NOUN
8c97kp81j4j	12	7	-	-	PUNCT
8c97kp81j4j	12	8	methyl	methyl	NOUN
8c97kp81j4j	12	9	plays	play	NOUN
8c97kp81j4j	12	10	in	in	ADP
8c97kp81j4j	12	11	determination	determination	NOUN
8c97kp81j4j	12	12	the	the	DET
8c97kp81j4j	12	13	conformational	conformational	ADJ
8c97kp81j4j	12	14	preferences	preference	NOUN
8c97kp81j4j	12	15	and	and	CCONJ
8c97kp81j4j	12	16	the	the	DET
8c97kp81j4j	12	17	biological	biological	ADJ
8c97kp81j4j	12	18	properties	property	NOUN
8c97kp81j4j	12	19	of	of	ADP
8c97kp81j4j	12	20	zampanolide	zampanolide	NOUN
8c97kp81j4j	12	21	and	and	CCONJ
8c97kp81j4j	12	22	dactylolide	dactylolide	PROPN
8c97kp81j4j	12	23	,	,	PUNCT
8c97kp81j4j	12	24	our	our	PRON
8c97kp81j4j	12	25	lab	lab	NOUN
8c97kp81j4j	12	26	has	have	AUX
8c97kp81j4j	12	27	completed	complete	VERB
8c97kp81j4j	12	28	a	a	DET
8c97kp81j4j	12	29	synthesis	synthesis	NOUN
8c97kp81j4j	12	30	of	of	ADP
8c97kp81j4j	12	31	a	a	DET
8c97kp81j4j	12	32	13	13	NUM
8c97kp81j4j	12	33	-	-	PUNCT
8c97kp81j4j	12	34	desmethylene-17	desmethylene-17	NOUN
8c97kp81j4j	12	35	-	-	PUNCT
8c97kp81j4j	12	36	methyl	methyl	NOUN
8c97kp81j4j	12	37	-	-	PUNCT
8c97kp81j4j	12	38	analogue	analogue	NOUN
8c97kp81j4j	12	39	series	series	NOUN
8c97kp81j4j	12	40	of	of	ADP
8c97kp81j4j	12	41	zampanolide	zampanolide	PROPN
8c97kp81j4j	12	42	and	and	CCONJ
8c97kp81j4j	12	43	dactylolide	dactylolide	PROPN
8c97kp81j4j	12	44	.	.	PUNCT
8c97kp81j4j	13	1	additionally	additionally	ADV
8c97kp81j4j	13	2	,	,	PUNCT
8c97kp81j4j	13	3	the	the	DET
8c97kp81j4j	13	4	removal	removal	NOUN
8c97kp81j4j	13	5	of	of	ADP
8c97kp81j4j	13	6	the	the	DET
8c97kp81j4j	13	7	alkyl	alkyl	ADJ
8c97kp81j4j	13	8	groups	group	NOUN
8c97kp81j4j	13	9	in	in	ADP
8c97kp81j4j	13	10	the	the	DET
8c97kp81j4j	13	11	analogues	analogue	NOUN
8c97kp81j4j	13	12	abbreviates	abbreviate	VERB
8c97kp81j4j	13	13	the	the	DET
8c97kp81j4j	13	14	synthesis	synthesis	NOUN
8c97kp81j4j	13	15	compared	compare	VERB
8c97kp81j4j	13	16	to	to	ADP
8c97kp81j4j	13	17	that	that	PRON
8c97kp81j4j	13	18	of	of	ADP
8c97kp81j4j	13	19	the	the	DET
8c97kp81j4j	13	20	natural	natural	ADJ
8c97kp81j4j	13	21	product	product	NOUN
8c97kp81j4j	13	22	.	.	PUNCT
8c97kp81j4j	14	1	upon	upon	SCONJ
8c97kp81j4j	14	2	completion	completion	NOUN
8c97kp81j4j	14	3	of	of	ADP
8c97kp81j4j	14	4	the	the	DET
8c97kp81j4j	14	5	analogue	analogue	NOUN
8c97kp81j4j	14	6	series	series	NOUN
8c97kp81j4j	14	7	,	,	PUNCT
8c97kp81j4j	14	8	our	our	PRON
8c97kp81j4j	14	9	lab	lab	NOUN
8c97kp81j4j	14	10	performed	perform	VERB
8c97kp81j4j	14	11	our	our	PRON
8c97kp81j4j	14	12	conformational	conformational	ADJ
8c97kp81j4j	14	13	analysis	analysis	NOUN
8c97kp81j4j	14	14	and	and	CCONJ
8c97kp81j4j	14	15	evaluated	evaluate	VERB
8c97kp81j4j	14	16	the	the	DET
8c97kp81j4j	14	17	cytotoxic	cytotoxic	ADJ
8c97kp81j4j	14	18	effects	effect	NOUN
8c97kp81j4j	14	19	to	to	PART
8c97kp81j4j	14	20	discern	discern	VERB
8c97kp81j4j	14	21	the	the	DET
8c97kp81j4j	14	22	relationship	relationship	NOUN
8c97kp81j4j	14	23	between	between	ADP
8c97kp81j4j	14	24	the	the	DET
8c97kp81j4j	14	25	macrolides	macrolide	NOUN
8c97kp81j4j	14	26	'	'	PART
8c97kp81j4j	14	27	conformational	conformational	ADJ
8c97kp81j4j	14	28	preferences	preference	NOUN
8c97kp81j4j	14	29	and	and	CCONJ
8c97kp81j4j	14	30	antiproliferative	antiproliferative	ADJ
8c97kp81j4j	14	31	effects	effect	NOUN
8c97kp81j4j	14	32	of	of	ADP
8c97kp81j4j	14	33	the	the	DET
8c97kp81j4j	14	34	natural	natural	ADJ
8c97kp81j4j	14	35	products.this	products.this	PRON
8c97kp81j4j	14	36	thesis	thesis	NOUN
8c97kp81j4j	14	37	also	also	ADV
8c97kp81j4j	14	38	addresses	address	VERB
8c97kp81j4j	14	39	our	our	PRON
8c97kp81j4j	14	40	efforts	effort	NOUN
8c97kp81j4j	14	41	to	to	PART
8c97kp81j4j	14	42	study	study	VERB
8c97kp81j4j	14	43	the	the	DET
8c97kp81j4j	14	44	relationship	relationship	NOUN
8c97kp81j4j	14	45	between	between	ADP
8c97kp81j4j	14	46	the	the	DET
8c97kp81j4j	14	47	biological	biological	ADJ
8c97kp81j4j	14	48	activity	activity	NOUN
8c97kp81j4j	14	49	and	and	CCONJ
8c97kp81j4j	14	50	conformational	conformational	ADJ
8c97kp81j4j	14	51	preferences	preference	NOUN
8c97kp81j4j	14	52	of	of	ADP
8c97kp81j4j	14	53	type	type	NOUN
8c97kp81j4j	14	54	-	-	PUNCT
8c97kp81j4j	14	55	i	i	PROPN
8c97kp81j4j	14	56	polyketide	polyketide	PROPN
8c97kp81j4j	14	57	gex1a	gex1a	PROPN
8c97kp81j4j	14	58	.	.	PUNCT
8c97kp81j4j	15	1	gex1a	gex1a	PROPN
8c97kp81j4j	15	2	proves	prove	VERB
8c97kp81j4j	15	3	to	to	PART
8c97kp81j4j	15	4	be	be	AUX
8c97kp81j4j	15	5	an	an	DET
8c97kp81j4j	15	6	interesting	interesting	ADJ
8c97kp81j4j	15	7	lead	lead	NOUN
8c97kp81j4j	15	8	for	for	ADP
8c97kp81j4j	15	9	a	a	DET
8c97kp81j4j	15	10	therapeutic	therapeutic	NOUN
8c97kp81j4j	15	11	in	in	ADP
8c97kp81j4j	15	12	our	our	PRON
8c97kp81j4j	15	13	acute	acute	ADJ
8c97kp81j4j	15	14	myeloid	myeloid	ADJ
8c97kp81j4j	15	15	leukemia	leukemia	NOUN
8c97kp81j4j	15	16	and	and	CCONJ
8c97kp81j4j	15	17	niemann	niemann	PROPN
8c97kp81j4j	15	18	-	-	PUNCT
8c97kp81j4j	15	19	pick	pick	NOUN
8c97kp81j4j	15	20	type	type	NOUN
8c97kp81j4j	15	21	c	c	NOUN
8c97kp81j4j	15	22	disease	disease	NOUN
8c97kp81j4j	15	23	studies	study	NOUN
8c97kp81j4j	15	24	and	and	CCONJ
8c97kp81j4j	15	25	requires	require	VERB
8c97kp81j4j	15	26	further	further	ADJ
8c97kp81j4j	15	27	evaluation	evaluation	NOUN
8c97kp81j4j	15	28	of	of	ADP
8c97kp81j4j	15	29	the	the	DET
8c97kp81j4j	15	30	compound	compound	NOUN
8c97kp81j4j	15	31	's	's	PART
8c97kp81j4j	15	32	potential	potential	NOUN
8c97kp81j4j	15	33	as	as	ADP
8c97kp81j4j	15	34	a	a	DET
8c97kp81j4j	15	35	drug	drug	NOUN
8c97kp81j4j	15	36	candidate	candidate	NOUN
8c97kp81j4j	15	37	.	.	PUNCT
8c97kp81j4j	16	1	two	two	NUM
8c97kp81j4j	16	2	chapters	chapter	NOUN
8c97kp81j4j	16	3	in	in	ADP
8c97kp81j4j	16	4	this	this	DET
8c97kp81j4j	16	5	thesis	thesis	NOUN
8c97kp81j4j	16	6	address	address	VERB
8c97kp81j4j	16	7	the	the	DET
8c97kp81j4j	16	8	background	background	NOUN
8c97kp81j4j	16	9	and	and	CCONJ
8c97kp81j4j	16	10	our	our	PRON
8c97kp81j4j	16	11	investigation	investigation	NOUN
8c97kp81j4j	16	12	in	in	ADP
8c97kp81j4j	16	13	the	the	DET
8c97kp81j4j	16	14	characterization	characterization	NOUN
8c97kp81j4j	16	15	of	of	ADP
8c97kp81j4j	16	16	gex1a	gex1a	SPACE
8c97kp81j4j	16	17	's	's	PART
8c97kp81j4j	16	18	conformation	conformation	NOUN
8c97kp81j4j	16	19	-	-	PUNCT
8c97kp81j4j	16	20	activation	activation	NOUN
8c97kp81j4j	16	21	activity	activity	NOUN
8c97kp81j4j	16	22	relationship	relationship	NOUN
8c97kp81j4j	16	23	using	use	VERB
8c97kp81j4j	16	24	computational	computational	ADJ
8c97kp81j4j	16	25	and	and	CCONJ
8c97kp81j4j	16	26	solutional	solutional	ADJ
8c97kp81j4j	16	27	nmr	nmr	NOUN
8c97kp81j4j	16	28	studies	study	NOUN
8c97kp81j4j	16	29	.	.	PUNCT
8c97kp81j4j	17	1	these	these	DET
8c97kp81j4j	17	2	studies	study	NOUN
8c97kp81j4j	17	3	confirm	confirm	VERB
8c97kp81j4j	17	4	previously	previously	ADV
8c97kp81j4j	17	5	predicted	predict	VERB
8c97kp81j4j	17	6	conformational	conformational	ADJ
8c97kp81j4j	17	7	preferences	preference	NOUN
8c97kp81j4j	17	8	of	of	ADP
8c97kp81j4j	17	9	the	the	DET
8c97kp81j4j	17	10	polyketide	polyketide	NOUN
8c97kp81j4j	17	11	and	and	CCONJ
8c97kp81j4j	17	12	identifies	identify	VERB
8c97kp81j4j	17	13	two	two	NUM
8c97kp81j4j	17	14	previously	previously	ADV
8c97kp81j4j	17	15	undiscovered	undiscovered	ADJ
8c97kp81j4j	17	16	bond	bond	NOUN
8c97kp81j4j	17	17	rotations	rotation	NOUN
8c97kp81j4j	17	18	that	that	PRON
8c97kp81j4j	17	19	promote	promote	VERB
8c97kp81j4j	17	20	the	the	DET
8c97kp81j4j	17	21	identification	identification	NOUN
8c97kp81j4j	17	22	of	of	ADP
8c97kp81j4j	17	23	four	four	NUM
8c97kp81j4j	17	24	potential	potential	ADJ
8c97kp81j4j	17	25	conformational	conformational	ADJ
8c97kp81j4j	17	26	families	family	NOUN
8c97kp81j4j	17	27	.	.	PUNCT
8c97kp81j4j	18	1	this	this	DET
8c97kp81j4j	18	2	thesis	thesis	NOUN
8c97kp81j4j	18	3	further	far	ADV
8c97kp81j4j	18	4	proposes	propose	VERB
8c97kp81j4j	18	5	to	to	PART
8c97kp81j4j	18	6	complete	complete	VERB
8c97kp81j4j	18	7	a	a	DET
8c97kp81j4j	18	8	synthesis	synthesis	NOUN
8c97kp81j4j	18	9	towards	towards	ADP
8c97kp81j4j	18	10	a	a	DET
8c97kp81j4j	18	11	methyl	methyl	NOUN
8c97kp81j4j	18	12	-	-	PUNCT
8c97kp81j4j	18	13	shifted	shift	VERB
8c97kp81j4j	18	14	analogue	analogue	NOUN
8c97kp81j4j	18	15	that	that	PRON
8c97kp81j4j	18	16	is	be	AUX
8c97kp81j4j	18	17	predicted	predict	VERB
8c97kp81j4j	18	18	to	to	PART
8c97kp81j4j	18	19	force	force	VERB
8c97kp81j4j	18	20	the	the	DET
8c97kp81j4j	18	21	analogue	analogue	NOUN
8c97kp81j4j	18	22	into	into	ADP
8c97kp81j4j	18	23	a	a	DET
8c97kp81j4j	18	24	specific	specific	ADJ
8c97kp81j4j	18	25	conformational	conformational	ADJ
8c97kp81j4j	18	26	family	family	NOUN
8c97kp81j4j	18	27	about	about	ADP
8c97kp81j4j	18	28	one	one	NUM
8c97kp81j4j	18	29	of	of	ADP
8c97kp81j4j	18	30	the	the	DET
8c97kp81j4j	18	31	rotatable	rotatable	ADJ
8c97kp81j4j	18	32	bond	bond	NOUN
8c97kp81j4j	18	33	dihedrals.together	dihedrals.together	ADV
8c97kp81j4j	18	34	,	,	PUNCT
8c97kp81j4j	18	35	these	these	DET
8c97kp81j4j	18	36	projects	project	NOUN
8c97kp81j4j	18	37	highlight	highlight	VERB
8c97kp81j4j	18	38	our	our	PRON
8c97kp81j4j	18	39	lab	lab	NOUN
8c97kp81j4j	18	40	's	's	PART
8c97kp81j4j	18	41	over	over	ADV
8c97kp81j4j	18	42	-	-	PUNCT
8c97kp81j4j	18	43	arching	arch	VERB
8c97kp81j4j	18	44	program	program	NOUN
8c97kp81j4j	18	45	to	to	PART
8c97kp81j4j	18	46	investigate	investigate	VERB
8c97kp81j4j	18	47	natural	natural	ADJ
8c97kp81j4j	18	48	products	product	NOUN
8c97kp81j4j	18	49	'	'	PART
8c97kp81j4j	18	50	therapeutic	therapeutic	ADJ
8c97kp81j4j	18	51	potential	potential	NOUN
8c97kp81j4j	18	52	for	for	ADP
8c97kp81j4j	18	53	treatment	treatment	NOUN
8c97kp81j4j	18	54	of	of	ADP
8c97kp81j4j	18	55	disease	disease	NOUN
8c97kp81j4j	18	56	.	.	PUNCT
8c97kp81j4j	19	1	this	this	DET
8c97kp81j4j	19	2	thesis	thesis	NOUN
8c97kp81j4j	19	3	places	place	VERB
8c97kp81j4j	19	4	specific	specific	ADJ
8c97kp81j4j	19	5	interest	interest	NOUN
8c97kp81j4j	19	6	in	in	ADP
8c97kp81j4j	19	7	characterizing	characterize	VERB
8c97kp81j4j	19	8	the	the	DET
8c97kp81j4j	19	9	conformational	conformational	ADJ
8c97kp81j4j	19	10	preferences	preference	NOUN
8c97kp81j4j	19	11	of	of	ADP
8c97kp81j4j	19	12	the	the	DET
8c97kp81j4j	19	13	natural	natural	ADJ
8c97kp81j4j	19	14	products	product	NOUN
8c97kp81j4j	19	15	and	and	CCONJ
8c97kp81j4j	19	16	relate	relate	VERB
8c97kp81j4j	19	17	the	the	DET
8c97kp81j4j	19	18	derived	derived	ADJ
8c97kp81j4j	19	19	conformational	conformational	ADJ
8c97kp81j4j	19	20	families	family	NOUN
8c97kp81j4j	19	21	to	to	ADP
8c97kp81j4j	19	22	the	the	DET
8c97kp81j4j	19	23	biological	biological	ADJ
8c97kp81j4j	19	24	properties	property	NOUN
8c97kp81j4j	19	25	of	of	ADP
8c97kp81j4j	19	26	the	the	DET
8c97kp81j4j	19	27	compounds	compound	NOUN
8c97kp81j4j	19	28	.	.	PUNCT