id sid tid token lemma pos 8336h131q0x 1 1 this this DET 8336h131q0x 1 2 dissertation dissertation NOUN 8336h131q0x 1 3 will will AUX 8336h131q0x 1 4 describe describe VERB 8336h131q0x 1 5 the the DET 8336h131q0x 1 6 design design NOUN 8336h131q0x 1 7 , , PUNCT 8336h131q0x 1 8 characterization characterization NOUN 8336h131q0x 1 9 , , PUNCT 8336h131q0x 1 10 biodistribution biodistribution NOUN 8336h131q0x 1 11 , , PUNCT 8336h131q0x 1 12 and and CCONJ 8336h131q0x 1 13 efficacy efficacy NOUN 8336h131q0x 1 14 of of ADP 8336h131q0x 1 15 peptide peptide NOUN 8336h131q0x 1 16 - - PUNCT 8336h131q0x 1 17 targeted target VERB 8336h131q0x 1 18 liposomes liposome NOUN 8336h131q0x 1 19 for for ADP 8336h131q0x 1 20 use use NOUN 8336h131q0x 1 21 in in ADP 8336h131q0x 1 22 selective selective ADJ 8336h131q0x 1 23 treatment treatment NOUN 8336h131q0x 1 24 of of ADP 8336h131q0x 1 25 multiple multiple ADJ 8336h131q0x 1 26 myeloma myeloma NOUN 8336h131q0x 1 27 . . PUNCT 8336h131q0x 2 1 multiple multiple ADJ 8336h131q0x 2 2 myeloma myeloma NOUN 8336h131q0x 2 3 ( ( PUNCT 8336h131q0x 2 4 mm mm PROPN 8336h131q0x 2 5 ) ) PUNCT 8336h131q0x 2 6 is be AUX 8336h131q0x 2 7 a a DET 8336h131q0x 2 8 plasma plasma NOUN 8336h131q0x 2 9 cell cell NOUN 8336h131q0x 2 10 malignancy malignancy NOUN 8336h131q0x 2 11 that that PRON 8336h131q0x 2 12 forms form VERB 8336h131q0x 2 13 solid solid ADJ 8336h131q0x 2 14 lesions lesion NOUN 8336h131q0x 2 15 in in ADP 8336h131q0x 2 16 the the DET 8336h131q0x 2 17 bone bone NOUN 8336h131q0x 2 18 marrow marrow NOUN 8336h131q0x 2 19 . . PUNCT 8336h131q0x 3 1 it it PRON 8336h131q0x 3 2 is be AUX 8336h131q0x 3 3 estimated estimate VERB 8336h131q0x 3 4 that that SCONJ 8336h131q0x 3 5 86,000 86,000 NUM 8336h131q0x 3 6 new new ADJ 8336h131q0x 3 7 cases case NOUN 8336h131q0x 3 8 appear appear VERB 8336h131q0x 3 9 each each DET 8336h131q0x 3 10 year year NOUN 8336h131q0x 3 11 worldwide worldwide ADV 8336h131q0x 3 12 , , PUNCT 8336h131q0x 3 13 and and CCONJ 8336h131q0x 3 14 it it PRON 8336h131q0x 3 15 is be AUX 8336h131q0x 3 16 responsible responsible ADJ 8336h131q0x 3 17 for for ADP 8336h131q0x 3 18 about about ADV 8336h131q0x 3 19 1 1 NUM 8336h131q0x 3 20 % % NOUN 8336h131q0x 3 21 of of ADP 8336h131q0x 3 22 all all DET 8336h131q0x 3 23 cancer cancer NOUN 8336h131q0x 3 24 deaths death NOUN 8336h131q0x 3 25 . . PUNCT 8336h131q0x 4 1 it it PRON 8336h131q0x 4 2 remains remain VERB 8336h131q0x 4 3 incurable incurable ADJ 8336h131q0x 4 4 with with ADP 8336h131q0x 4 5 a a DET 8336h131q0x 4 6 median median ADJ 8336h131q0x 4 7 survival survival NOUN 8336h131q0x 4 8 of of ADP 8336h131q0x 4 9 5 5 NUM 8336h131q0x 4 10 years year NOUN 8336h131q0x 4 11 due due ADJ 8336h131q0x 4 12 to to ADP 8336h131q0x 4 13 recurrence recurrence NOUN 8336h131q0x 4 14 and and CCONJ 8336h131q0x 4 15 development development NOUN 8336h131q0x 4 16 of of ADP 8336h131q0x 4 17 drug drug NOUN 8336h131q0x 4 18 resistance resistance NOUN 8336h131q0x 4 19 . . PUNCT 8336h131q0x 5 1 actively actively ADV 8336h131q0x 5 2 targeted target VERB 8336h131q0x 5 3 liposomal liposomal ADJ 8336h131q0x 5 4 treatments treatment NOUN 8336h131q0x 5 5 have have AUX 8336h131q0x 5 6 been be AUX 8336h131q0x 5 7 shown show VERB 8336h131q0x 5 8 to to PART 8336h131q0x 5 9 be be AUX 8336h131q0x 5 10 able able ADJ 8336h131q0x 5 11 to to PART 8336h131q0x 5 12 overcome overcome VERB 8336h131q0x 5 13 drug drug NOUN 8336h131q0x 5 14 resistance resistance NOUN 8336h131q0x 5 15 in in ADP 8336h131q0x 5 16 other other ADJ 8336h131q0x 5 17 types type NOUN 8336h131q0x 5 18 of of ADP 8336h131q0x 5 19 cancers cancer NOUN 8336h131q0x 5 20 , , PUNCT 8336h131q0x 5 21 including include VERB 8336h131q0x 5 22 those those PRON 8336h131q0x 5 23 in in ADP 8336h131q0x 5 24 the the DET 8336h131q0x 5 25 bone bone NOUN 8336h131q0x 5 26 marrow marrow NOUN 8336h131q0x 5 27 . . PUNCT 8336h131q0x 6 1 in in ADP 8336h131q0x 6 2 light light NOUN 8336h131q0x 6 3 of of ADP 8336h131q0x 6 4 this this PRON 8336h131q0x 6 5 , , PUNCT 8336h131q0x 6 6 a a DET 8336h131q0x 6 7 targeted target VERB 8336h131q0x 6 8 delivery delivery NOUN 8336h131q0x 6 9 system system NOUN 8336h131q0x 6 10 would would AUX 8336h131q0x 6 11 be be AUX 8336h131q0x 6 12 likely likely ADV 8336h131q0x 6 13 be be AUX 8336h131q0x 6 14 effective effective ADJ 8336h131q0x 6 15 in in ADP 8336h131q0x 6 16 improving improve VERB 8336h131q0x 6 17 mm mm PROPN 8336h131q0x 6 18 treatment treatment NOUN 8336h131q0x 6 19 outcomes outcome NOUN 8336h131q0x 6 20 . . PUNCT 8336h131q0x 7 1 liposomes liposome NOUN 8336h131q0x 7 2 are be AUX 8336h131q0x 7 3 a a DET 8336h131q0x 7 4 nanoparticle nanoparticle NOUN 8336h131q0x 7 5 consisting consist VERB 8336h131q0x 7 6 of of ADP 8336h131q0x 7 7 a a DET 8336h131q0x 7 8 spherical spherical ADJ 8336h131q0x 7 9 lipid lipid NOUN 8336h131q0x 7 10 bilayer bilayer NOUN 8336h131q0x 7 11 with with ADP 8336h131q0x 7 12 various various ADJ 8336h131q0x 7 13 elements element NOUN 8336h131q0x 7 14 either either CCONJ 8336h131q0x 7 15 contained contain VERB 8336h131q0x 7 16 in in ADP 8336h131q0x 7 17 the the DET 8336h131q0x 7 18 aqueous aqueous ADJ 8336h131q0x 7 19 core core NOUN 8336h131q0x 7 20 , , PUNCT 8336h131q0x 7 21 trapped trap VERB 8336h131q0x 7 22 in in ADP 8336h131q0x 7 23 the the DET 8336h131q0x 7 24 lipophilic lipophilic ADJ 8336h131q0x 7 25 bilayer bilayer NOUN 8336h131q0x 7 26 , , PUNCT 8336h131q0x 7 27 or or CCONJ 8336h131q0x 7 28 attached attach VERB 8336h131q0x 7 29 to to ADP 8336h131q0x 7 30 a a DET 8336h131q0x 7 31 lipid lipid NOUN 8336h131q0x 7 32 to to PART 8336h131q0x 7 33 be be AUX 8336h131q0x 7 34 presented present VERB 8336h131q0x 7 35 on on ADP 8336h131q0x 7 36 the the DET 8336h131q0x 7 37 surface surface NOUN 8336h131q0x 7 38 . . PUNCT 8336h131q0x 8 1 they they PRON 8336h131q0x 8 2 are be AUX 8336h131q0x 8 3 highly highly ADV 8336h131q0x 8 4 modifiable modifiable ADJ 8336h131q0x 8 5 and and CCONJ 8336h131q0x 8 6 can can AUX 8336h131q0x 8 7 be be AUX 8336h131q0x 8 8 designed design VERB 8336h131q0x 8 9 to to PART 8336h131q0x 8 10 deliver deliver VERB 8336h131q0x 8 11 a a DET 8336h131q0x 8 12 wide wide ADJ 8336h131q0x 8 13 range range NOUN 8336h131q0x 8 14 of of ADP 8336h131q0x 8 15 drugs drug NOUN 8336h131q0x 8 16 and and CCONJ 8336h131q0x 8 17 present present ADJ 8336h131q0x 8 18 molecules molecule NOUN 8336h131q0x 8 19 on on ADP 8336h131q0x 8 20 the the DET 8336h131q0x 8 21 surface surface NOUN 8336h131q0x 8 22 for for ADP 8336h131q0x 8 23 targeting targeting NOUN 8336h131q0x 8 24 purposes purpose NOUN 8336h131q0x 8 25 . . PUNCT 8336h131q0x 9 1 in in ADP 8336h131q0x 9 2 order order NOUN 8336h131q0x 9 3 to to PART 8336h131q0x 9 4 selectively selectively ADV 8336h131q0x 9 5 target target VERB 8336h131q0x 9 6 mm mm NOUN 8336h131q0x 9 7 cells cell NOUN 8336h131q0x 9 8 , , PUNCT 8336h131q0x 9 9 we we PRON 8336h131q0x 9 10 discovered discover VERB 8336h131q0x 9 11 or or CCONJ 8336h131q0x 9 12 designed design VERB 8336h131q0x 9 13 short short ADJ 8336h131q0x 9 14 targeting targeting NOUN 8336h131q0x 9 15 peptide peptide NOUN 8336h131q0x 9 16 sequences sequence NOUN 8336h131q0x 9 17 that that PRON 8336h131q0x 9 18 specifically specifically ADV 8336h131q0x 9 19 bind bind VERB 8336h131q0x 9 20 to to ADP 8336h131q0x 9 21 receptors receptor NOUN 8336h131q0x 9 22 frequently frequently ADV 8336h131q0x 9 23 overexpressed overexpresse VERB 8336h131q0x 9 24 in in ADP 8336h131q0x 9 25 mm mm NOUN 8336h131q0x 9 26 cases case NOUN 8336h131q0x 9 27 such such ADJ 8336h131q0x 9 28 as as ADP 8336h131q0x 9 29 vla-4 vla-4 SPACE 8336h131q0x 9 30 , , PUNCT 8336h131q0x 9 31 lpam1 lpam1 PROPN 8336h131q0x 9 32 , , PUNCT 8336h131q0x 9 33 cd38 cd38 PROPN 8336h131q0x 9 34 , , PUNCT 8336h131q0x 9 35 and and CCONJ 8336h131q0x 9 36 cd138 cd138 PROPN 8336h131q0x 9 37 . . PROPN 8336h131q0x 10 1 specifically specifically ADV 8336h131q0x 10 2 , , PUNCT 8336h131q0x 10 3 the the DET 8336h131q0x 10 4 design design NOUN 8336h131q0x 10 5 and and CCONJ 8336h131q0x 10 6 evaluation evaluation NOUN 8336h131q0x 10 7 of of ADP 8336h131q0x 10 8 a a DET 8336h131q0x 10 9 liposomal liposomal ADJ 8336h131q0x 10 10 system system NOUN 8336h131q0x 10 11 targeting target VERB 8336h131q0x 10 12 both both PRON 8336h131q0x 10 13 vla-4 vla-4 NOUN 8336h131q0x 10 14 and and CCONJ 8336h131q0x 10 15 lpam-1 lpam-1 PROPN 8336h131q0x 10 16 in in ADP 8336h131q0x 10 17 vitro vitro X 8336h131q0x 10 18 will will AUX 8336h131q0x 10 19 be be AUX 8336h131q0x 10 20 explored explore VERB 8336h131q0x 10 21 in in ADP 8336h131q0x 10 22 chapter chapter NOUN 8336h131q0x 10 23 2 2 NUM 8336h131q0x 10 24 . . PUNCT 8336h131q0x 10 25 vla-4 vla-4 ADP 8336h131q0x 10 26 liposomes liposome NOUN 8336h131q0x 10 27 will will AUX 8336h131q0x 10 28 then then ADV 8336h131q0x 10 29 be be AUX 8336h131q0x 10 30 further far ADV 8336h131q0x 10 31 optimized optimize VERB 8336h131q0x 10 32 for for ADP 8336h131q0x 10 33 in in ADP 8336h131q0x 10 34 vivo vivo ADJ 8336h131q0x 10 35 delivery delivery NOUN 8336h131q0x 10 36 to to ADP 8336h131q0x 10 37 a a DET 8336h131q0x 10 38 tumor tumor NOUN 8336h131q0x 10 39 in in ADP 8336h131q0x 10 40 chapter chapter NOUN 8336h131q0x 10 41 3 3 NUM 8336h131q0x 10 42 . . PUNCT 8336h131q0x 11 1 then then ADV 8336h131q0x 11 2 the the DET 8336h131q0x 11 3 knowledge knowledge NOUN 8336h131q0x 11 4 gained gain VERB 8336h131q0x 11 5 from from ADP 8336h131q0x 11 6 designing design VERB 8336h131q0x 11 7 this this PRON 8336h131q0x 11 8 in in ADP 8336h131q0x 11 9 vivo vivo ADJ 8336h131q0x 11 10 system system NOUN 8336h131q0x 11 11 will will AUX 8336h131q0x 11 12 be be AUX 8336h131q0x 11 13 used use VERB 8336h131q0x 11 14 in in ADP 8336h131q0x 11 15 chapter chapter NOUN 8336h131q0x 11 16 3 3 NUM 8336h131q0x 11 17 to to PART 8336h131q0x 11 18 design design VERB 8336h131q0x 11 19 additional additional ADJ 8336h131q0x 11 20 liposomes liposome NOUN 8336h131q0x 11 21 for for ADP 8336h131q0x 11 22 delivery delivery NOUN 8336h131q0x 11 23 of of ADP 8336h131q0x 11 24 chemotherapeutics chemotherapeutic NOUN 8336h131q0x 11 25 in in ADP 8336h131q0x 11 26 vivo vivo NOUN 8336h131q0x 11 27 via via ADP 8336h131q0x 11 28 targeting targeting NOUN 8336h131q0x 11 29 of of ADP 8336h131q0x 11 30 cd38 cd38 PROPN 8336h131q0x 11 31 and and CCONJ 8336h131q0x 11 32 cd138 cd138 PROPN 8336h131q0x 11 33 . . PROPN 8336h131q0x 12 1 finally finally ADV 8336h131q0x 12 2 , , PUNCT 8336h131q0x 12 3 chapter chapter NOUN 8336h131q0x 12 4 4 4 NUM 8336h131q0x 12 5 will will AUX 8336h131q0x 12 6 cover cover VERB 8336h131q0x 12 7 and and CCONJ 8336h131q0x 12 8 compare compare VERB 8336h131q0x 12 9 all all DET 8336h131q0x 12 10 previously previously ADV 8336h131q0x 12 11 evaluated evaluate VERB 8336h131q0x 12 12 targeted target VERB 8336h131q0x 12 13 liposomes liposome NOUN 8336h131q0x 12 14 as as ADV 8336h131q0x 12 15 well well ADV 8336h131q0x 12 16 as as ADP 8336h131q0x 12 17 using use VERB 8336h131q0x 12 18 the the DET 8336h131q0x 12 19 tumor tumor NOUN 8336h131q0x 12 20 - - PUNCT 8336h131q0x 12 21 penetrating penetrate VERB 8336h131q0x 12 22 peptide peptide NOUN 8336h131q0x 12 23 irgd irgd NOUN 8336h131q0x 12 24 and and CCONJ 8336h131q0x 12 25 their their PRON 8336h131q0x 12 26 uptake uptake NOUN 8336h131q0x 12 27 in in ADP 8336h131q0x 12 28 vitro vitro X 8336h131q0x 12 29 and and CCONJ 8336h131q0x 12 30 biodistribution biodistribution NOUN 8336h131q0x 12 31 and and CCONJ 8336h131q0x 12 32 tumor tumor NOUN 8336h131q0x 12 33 cell cell NOUN 8336h131q0x 12 34 uptake uptake NOUN 8336h131q0x 12 35 in in ADP 8336h131q0x 12 36 vivo vivo PROPN 8336h131q0x 12 37 . . PUNCT