id	sid	tid	token	lemma	pos
7w62f76437h	1	1	in	in	ADP
7w62f76437h	1	2	only	only	ADV
7w62f76437h	1	3	seven	seven	NUM
7w62f76437h	1	4	decades	decade	NOUN
7w62f76437h	1	5	since	since	SCONJ
7w62f76437h	1	6	the	the	DET
7w62f76437h	1	7	development	development	NOUN
7w62f76437h	1	8	of	of	ADP
7w62f76437h	1	9	penicillin	penicillin	NOUN
7w62f76437h	1	10	,	,	PUNCT
7w62f76437h	1	11	antibiotic	antibiotic	ADJ
7w62f76437h	1	12	resistance	resistance	NOUN
7w62f76437h	1	13	has	have	AUX
7w62f76437h	1	14	become	become	VERB
7w62f76437h	1	15	a	a	DET
7w62f76437h	1	16	widespread	widespread	ADJ
7w62f76437h	1	17	problem	problem	NOUN
7w62f76437h	1	18	of	of	ADP
7w62f76437h	1	19	the	the	DET
7w62f76437h	1	20	modern	modern	ADJ
7w62f76437h	1	21	world	world	NOUN
7w62f76437h	1	22	to	to	PART
7w62f76437h	1	23	which	which	PRON
7w62f76437h	1	24	only	only	ADV
7w62f76437h	1	25	few	few	ADJ
7w62f76437h	1	26	solutions	solution	NOUN
7w62f76437h	1	27	currently	currently	ADV
7w62f76437h	1	28	exist	exist	VERB
7w62f76437h	1	29	.	.	PUNCT
7w62f76437h	2	1	the	the	DET
7w62f76437h	2	2	fast	fast	ADV
7w62f76437h	2	3	paced	pace	VERB
7w62f76437h	2	4	rhythm	rhythm	NOUN
7w62f76437h	2	5	of	of	ADP
7w62f76437h	2	6	evolution	evolution	NOUN
7w62f76437h	2	7	in	in	ADP
7w62f76437h	2	8	the	the	DET
7w62f76437h	2	9	world	world	NOUN
7w62f76437h	2	10	of	of	ADP
7w62f76437h	2	11	bacteria	bacteria	NOUN
7w62f76437h	2	12	is	be	AUX
7w62f76437h	2	13	surpassing	surpass	VERB
7w62f76437h	2	14	the	the	DET
7w62f76437h	2	15	rate	rate	NOUN
7w62f76437h	2	16	of	of	ADP
7w62f76437h	2	17	drug	drug	NOUN
7w62f76437h	2	18	discovery	discovery	NOUN
7w62f76437h	2	19	,	,	PUNCT
7w62f76437h	2	20	with	with	ADP
7w62f76437h	2	21	mrsa	mrsa	PROPN
7w62f76437h	2	22	(	(	PUNCT
7w62f76437h	2	23	a	a	DET
7w62f76437h	2	24	strain	strain	NOUN
7w62f76437h	2	25	of	of	ADP
7w62f76437h	2	26	s.	s.	PROPN
7w62f76437h	2	27	aureus	aureus	PROPN
7w62f76437h	2	28	resistant	resistant	ADJ
7w62f76437h	2	29	to	to	ADP
7w62f76437h	2	30	methicillin	methicillin	NOUN
7w62f76437h	2	31	,	,	PUNCT
7w62f76437h	2	32	a	a	DET
7w62f76437h	2	33	second	second	ADJ
7w62f76437h	2	34	generation	generation	NOUN
7w62f76437h	2	35	ì_å_-lactam	ì_å_-lactam	NOUN
7w62f76437h	2	36	antibiotic	antibiotic	ADJ
7w62f76437h	2	37	)	)	PUNCT
7w62f76437h	2	38	being	be	AUX
7w62f76437h	2	39	one	one	NUM
7w62f76437h	2	40	of	of	ADP
7w62f76437h	2	41	the	the	DET
7w62f76437h	2	42	favorites	favorite	NOUN
7w62f76437h	2	43	in	in	ADP
7w62f76437h	2	44	the	the	DET
7w62f76437h	2	45	race	race	NOUN
7w62f76437h	2	46	.	.	PUNCT
7w62f76437h	3	1	responsible	responsible	ADJ
7w62f76437h	3	2	for	for	ADP
7w62f76437h	3	3	this	this	DET
7w62f76437h	3	4	resistance	resistance	NOUN
7w62f76437h	3	5	are	be	AUX
7w62f76437h	3	6	the	the	DET
7w62f76437h	3	7	sensing	sense	VERB
7w62f76437h	3	8	/	/	SYM
7w62f76437h	3	9	transducing	transducing	NOUN
7w62f76437h	3	10	systems	system	NOUN
7w62f76437h	3	11	blar	blar	ADJ
7w62f76437h	3	12	and	and	CCONJ
7w62f76437h	3	13	mecr	mecr	NOUN
7w62f76437h	3	14	.	.	PUNCT
7w62f76437h	4	1	upon	upon	SCONJ
7w62f76437h	4	2	interaction	interaction	NOUN
7w62f76437h	4	3	with	with	ADP
7w62f76437h	4	4	the	the	DET
7w62f76437h	4	5	ì_å_-lactam	ì_å_-lactam	NOUN
7w62f76437h	4	6	antibiotic	antibiotic	ADJ
7w62f76437h	4	7	through	through	ADP
7w62f76437h	4	8	its	its	PRON
7w62f76437h	4	9	surface	surface	NOUN
7w62f76437h	4	10	domain	domain	NOUN
7w62f76437h	4	11	,	,	PUNCT
7w62f76437h	4	12	blar	blar	ADJ
7w62f76437h	4	13	initiates	initiate	VERB
7w62f76437h	4	14	the	the	DET
7w62f76437h	4	15	signal	signal	ADJ
7w62f76437h	4	16	transduction	transduction	NOUN
7w62f76437h	4	17	process	process	NOUN
7w62f76437h	4	18	.	.	PUNCT
7w62f76437h	5	1	this	this	DET
7w62f76437h	5	2	event	event	NOUN
7w62f76437h	5	3	leads	lead	VERB
7w62f76437h	5	4	to	to	ADP
7w62f76437h	5	5	the	the	DET
7w62f76437h	5	6	activation	activation	NOUN
7w62f76437h	5	7	of	of	ADP
7w62f76437h	5	8	the	the	DET
7w62f76437h	5	9	cytoplasmic	cytoplasmic	ADJ
7w62f76437h	5	10	domain	domain	NOUN
7w62f76437h	5	11	,	,	PUNCT
7w62f76437h	5	12	with	with	ADP
7w62f76437h	5	13	the	the	DET
7w62f76437h	5	14	final	final	ADJ
7w62f76437h	5	15	result	result	NOUN
7w62f76437h	5	16	of	of	ADP
7w62f76437h	5	17	de	de	NOUN
7w62f76437h	5	18	-	-	NOUN
7w62f76437h	5	19	repression	repression	NOUN
7w62f76437h	5	20	of	of	ADP
7w62f76437h	5	21	blaz	blaz	ADJ
7w62f76437h	5	22	,	,	PUNCT
7w62f76437h	5	23	the	the	DET
7w62f76437h	5	24	ì_å	ì_å	SPACE
7w62f76437h	5	25	_	_	NOUN
7w62f76437h	5	26	lactamase	lactamase	NOUN
7w62f76437h	5	27	encoding	encoding	NOUN
7w62f76437h	5	28	gene	gene	NOUN
7w62f76437h	5	29	.	.	PUNCT
7w62f76437h	6	1	as	as	SCONJ
7w62f76437h	6	2	shown	show	VERB
7w62f76437h	6	3	by	by	ADP
7w62f76437h	6	4	mobashery	mobashery	NOUN
7w62f76437h	6	5	et	et	PROPN
7w62f76437h	6	6	al	al	PROPN
7w62f76437h	6	7	.	.	PUNCT
7w62f76437h	7	1	[	[	X
7w62f76437h	7	2	1	1	X
7w62f76437h	7	3	]	]	PUNCT
7w62f76437h	7	4	,	,	PUNCT
7w62f76437h	7	5	the	the	DET
7w62f76437h	7	6	signal	signal	NOUN
7w62f76437h	7	7	transduction	transduction	NOUN
7w62f76437h	7	8	process	process	NOUN
7w62f76437h	7	9	involves	involve	VERB
7w62f76437h	7	10	conformational	conformational	ADJ
7w62f76437h	7	11	changes	change	NOUN
7w62f76437h	7	12	of	of	ADP
7w62f76437h	7	13	the	the	DET
7w62f76437h	7	14	cell	cell	NOUN
7w62f76437h	7	15	surface	surface	NOUN
7w62f76437h	7	16	sensor	sensor	NOUN
7w62f76437h	7	17	domain	domain	NOUN
7w62f76437h	7	18	of	of	ADP
7w62f76437h	7	19	the	the	DET
7w62f76437h	7	20	blar	blar	ADJ
7w62f76437h	7	21	protein	protein	NOUN
7w62f76437h	7	22	upon	upon	SCONJ
7w62f76437h	7	23	ligand	ligand	NOUN
7w62f76437h	7	24	binding	binding	PROPN
7w62f76437h	7	25	.	.	PUNCT
7w62f76437h	8	1	this	this	PRON
7w62f76437h	8	2	prompts	prompt	VERB
7w62f76437h	8	3	the	the	DET
7w62f76437h	8	4	need	need	NOUN
7w62f76437h	8	5	to	to	PART
7w62f76437h	8	6	look	look	VERB
7w62f76437h	8	7	at	at	ADP
7w62f76437h	8	8	the	the	DET
7w62f76437h	8	9	dynamics	dynamic	NOUN
7w62f76437h	8	10	necessary	necessary	ADJ
7w62f76437h	8	11	to	to	ADP
7w62f76437h	8	12	the	the	DET
7w62f76437h	8	13	signaling	signal	VERB
7w62f76437h	8	14	mechanism	mechanism	NOUN
7w62f76437h	8	15	.	.	PUNCT
7w62f76437h	9	1	nuclear	nuclear	ADJ
7w62f76437h	9	2	magnetic	magnetic	ADJ
7w62f76437h	9	3	resonance	resonance	NOUN
7w62f76437h	9	4	(	(	PUNCT
7w62f76437h	9	5	nmr	nmr	NOUN
7w62f76437h	9	6	)	)	PUNCT
7w62f76437h	9	7	is	be	AUX
7w62f76437h	9	8	a	a	DET
7w62f76437h	9	9	spectroscopic	spectroscopic	ADJ
7w62f76437h	9	10	technique	technique	NOUN
7w62f76437h	9	11	that	that	PRON
7w62f76437h	9	12	provides	provide	VERB
7w62f76437h	9	13	an	an	DET
7w62f76437h	9	14	atomic	atomic	ADJ
7w62f76437h	9	15	resolution	resolution	NOUN
7w62f76437h	9	16	description	description	NOUN
7w62f76437h	9	17	of	of	ADP
7w62f76437h	9	18	the	the	DET
7w62f76437h	9	19	system	system	NOUN
7w62f76437h	9	20	of	of	ADP
7w62f76437h	9	21	interest	interest	NOUN
7w62f76437h	9	22	and	and	CCONJ
7w62f76437h	9	23	allows	allow	VERB
7w62f76437h	9	24	for	for	ADP
7w62f76437h	9	25	the	the	DET
7w62f76437h	9	26	study	study	NOUN
7w62f76437h	9	27	of	of	ADP
7w62f76437h	9	28	both	both	DET
7w62f76437h	9	29	protein	protein	NOUN
7w62f76437h	9	30	structure	structure	NOUN
7w62f76437h	9	31	and	and	CCONJ
7w62f76437h	9	32	dynamics	dynamic	NOUN
7w62f76437h	9	33	.	.	PUNCT
7w62f76437h	10	1	however	however	ADV
7w62f76437h	10	2	,	,	PUNCT
7w62f76437h	10	3	many	many	ADJ
7w62f76437h	10	4	interesting	interesting	ADJ
7w62f76437h	10	5	and	and	CCONJ
7w62f76437h	10	6	biologically	biologically	ADV
7w62f76437h	10	7	relevant	relevant	ADJ
7w62f76437h	10	8	proteins	protein	NOUN
7w62f76437h	10	9	pose	pose	VERB
7w62f76437h	10	10	experimental	experimental	ADJ
7w62f76437h	10	11	difficulties	difficulty	NOUN
7w62f76437h	10	12	due	due	ADP
7w62f76437h	10	13	to	to	ADP
7w62f76437h	10	14	their	their	PRON
7w62f76437h	10	15	large	large	ADJ
7w62f76437h	10	16	molecular	molecular	ADJ
7w62f76437h	10	17	weights	weight	NOUN
7w62f76437h	10	18	and	and	CCONJ
7w62f76437h	10	19	poor	poor	ADJ
7w62f76437h	10	20	stability	stability	NOUN
7w62f76437h	10	21	in	in	ADP
7w62f76437h	10	22	a	a	DET
7w62f76437h	10	23	highly	highly	ADV
7w62f76437h	10	24	concentrated	concentrate	VERB
7w62f76437h	10	25	solution	solution	NOUN
7w62f76437h	10	26	state	state	NOUN
7w62f76437h	10	27	.	.	PUNCT
7w62f76437h	11	1	practical	practical	ADJ
7w62f76437h	11	2	solutions	solution	NOUN
7w62f76437h	11	3	to	to	ADP
7w62f76437h	11	4	these	these	DET
7w62f76437h	11	5	experimental	experimental	ADJ
7w62f76437h	11	6	concerns	concern	NOUN
7w62f76437h	11	7	will	will	AUX
7w62f76437h	11	8	be	be	AUX
7w62f76437h	11	9	detailed	detail	VERB
7w62f76437h	11	10	within	within	ADP
7w62f76437h	11	11	this	this	DET
7w62f76437h	11	12	thesis	thesis	NOUN
7w62f76437h	11	13	.	.	PUNCT
7w62f76437h	12	1	the	the	DET
7w62f76437h	12	2	focus	focus	NOUN
7w62f76437h	12	3	of	of	ADP
7w62f76437h	12	4	this	this	DET
7w62f76437h	12	5	study	study	NOUN
7w62f76437h	12	6	will	will	AUX
7w62f76437h	12	7	be	be	AUX
7w62f76437h	12	8	the	the	DET
7w62f76437h	12	9	novel	novel	ADJ
7w62f76437h	12	10	characterization	characterization	NOUN
7w62f76437h	12	11	of	of	ADP
7w62f76437h	12	12	the	the	DET
7w62f76437h	12	13	s.	s.	PROPN
7w62f76437h	12	14	aureus	aureus	PROPN
7w62f76437h	12	15	blar	blar	ADJ
7w62f76437h	12	16	sensor	sensor	NOUN
7w62f76437h	12	17	domain	domain	NOUN
7w62f76437h	12	18	,	,	PUNCT
7w62f76437h	12	19	blars	blar	NOUN
7w62f76437h	12	20	(	(	PUNCT
7w62f76437h	12	21	30kda	30kda	NOUN
7w62f76437h	12	22	)	)	PUNCT
7w62f76437h	12	23	.	.	PUNCT
7w62f76437h	13	1	contained	contain	VERB
7w62f76437h	13	2	within	within	ADP
7w62f76437h	13	3	this	this	DET
7w62f76437h	13	4	thesis	thesis	NOUN
7w62f76437h	13	5	will	will	AUX
7w62f76437h	13	6	be	be	AUX
7w62f76437h	13	7	the	the	DET
7w62f76437h	13	8	initial	initial	ADJ
7w62f76437h	13	9	characterization	characterization	NOUN
7w62f76437h	13	10	of	of	ADP
7w62f76437h	13	11	blar	blar	ADJ
7w62f76437h	13	12	with	with	ADP
7w62f76437h	13	13	nmr	nmr	NOUN
7w62f76437h	13	14	in	in	ADP
7w62f76437h	13	15	both	both	CCONJ
7w62f76437h	13	16	the	the	DET
7w62f76437h	13	17	free	free	ADJ
7w62f76437h	13	18	and	and	CCONJ
7w62f76437h	13	19	antibiotic	antibiotic	ADJ
7w62f76437h	13	20	bound	bind	VERB
7w62f76437h	13	21	form	form	NOUN
7w62f76437h	13	22	.	.	PUNCT
7w62f76437h	14	1	these	these	DET
7w62f76437h	14	2	results	result	NOUN
7w62f76437h	14	3	provide	provide	VERB
7w62f76437h	14	4	the	the	DET
7w62f76437h	14	5	first	first	ADJ
7w62f76437h	14	6	atomic	atomic	ADJ
7w62f76437h	14	7	resolution	resolution	NOUN
7w62f76437h	14	8	study	study	NOUN
7w62f76437h	14	9	of	of	ADP
7w62f76437h	14	10	blars	blar	NOUN
7w62f76437h	14	11	and	and	CCONJ
7w62f76437h	14	12	its	its	PRON
7w62f76437h	14	13	associated	associated	ADJ
7w62f76437h	14	14	signaling	signal	VERB
7w62f76437h	14	15	mechanism	mechanism	NOUN
7w62f76437h	14	16	in	in	ADP
7w62f76437h	14	17	the	the	DET
7w62f76437h	14	18	solution	solution	NOUN
7w62f76437h	14	19	state	state	NOUN
7w62f76437h	14	20	,	,	PUNCT
7w62f76437h	14	21	and	and	CCONJ
7w62f76437h	14	22	supply	supply	VERB
7w62f76437h	14	23	initial	initial	ADJ
7w62f76437h	14	24	data	datum	NOUN
7w62f76437h	14	25	required	require	VERB
7w62f76437h	14	26	for	for	ADP
7w62f76437h	14	27	future	future	ADJ
7w62f76437h	14	28	studies	study	NOUN
7w62f76437h	14	29	.	.	PUNCT