id	sid	tid	token	lemma	pos
7m01bk15f0h	1	1	hmg	hmg	PROPN
7m01bk15f0h	1	2	-	-	PUNCT
7m01bk15f0h	1	3	coa	coa	NOUN
7m01bk15f0h	1	4	reductases	reductase	NOUN
7m01bk15f0h	1	5	are	be	AUX
7m01bk15f0h	1	6	four	four	NUM
7m01bk15f0h	1	7	electron	electron	NOUN
7m01bk15f0h	1	8	oxidoreductases	oxidoreductase	NOUN
7m01bk15f0h	1	9	that	that	PRON
7m01bk15f0h	1	10	process	process	VERB
7m01bk15f0h	1	11	three	three	NUM
7m01bk15f0h	1	12	substrates	substrate	NOUN
7m01bk15f0h	1	13	in	in	ADP
7m01bk15f0h	1	14	the	the	DET
7m01bk15f0h	1	15	same	same	ADJ
7m01bk15f0h	1	16	active	active	ADJ
7m01bk15f0h	1	17	site	site	NOUN
7m01bk15f0h	1	18	.	.	PUNCT
7m01bk15f0h	2	1	the	the	DET
7m01bk15f0h	2	2	computational	computational	ADJ
7m01bk15f0h	2	3	studies	study	NOUN
7m01bk15f0h	2	4	performed	perform	VERB
7m01bk15f0h	2	5	using	use	VERB
7m01bk15f0h	2	6	theozyme	theozyme	NOUN
7m01bk15f0h	2	7	(	(	PUNCT
7m01bk15f0h	2	8	dft	dft	NOUN
7m01bk15f0h	2	9	)	)	PUNCT
7m01bk15f0h	2	10	and	and	CCONJ
7m01bk15f0h	2	11	qm	qm	PROPN
7m01bk15f0h	2	12	/	/	SYM
7m01bk15f0h	2	13	mm	mm	NOUN
7m01bk15f0h	2	14	models	model	NOUN
7m01bk15f0h	2	15	show	show	VERB
7m01bk15f0h	2	16	that	that	SCONJ
7m01bk15f0h	2	17	the	the	DET
7m01bk15f0h	2	18	thiohemiacetal	thiohemiacetal	PROPN
7m01bk15f0h	2	19	decomposition	decomposition	NOUN
7m01bk15f0h	2	20	reaction	reaction	NOUN
7m01bk15f0h	2	21	,	,	PUNCT
7m01bk15f0h	2	22	that	that	PRON
7m01bk15f0h	2	23	occurs	occur	VERB
7m01bk15f0h	2	24	between	between	ADP
7m01bk15f0h	2	25	the	the	DET
7m01bk15f0h	2	26	two	two	NUM
7m01bk15f0h	2	27	hydride	hydride	NOUN
7m01bk15f0h	2	28	transfer	transfer	NOUN
7m01bk15f0h	2	29	reactions	reaction	NOUN
7m01bk15f0h	2	30	,	,	PUNCT
7m01bk15f0h	2	31	has	have	VERB
7m01bk15f0h	2	32	an	an	DET
7m01bk15f0h	2	33	energy	energy	NOUN
7m01bk15f0h	2	34	barrier	barrier	NOUN
7m01bk15f0h	2	35	of	of	ADP
7m01bk15f0h	2	36	~	~	PROPN
7m01bk15f0h	2	37	7	7	NUM
7m01bk15f0h	2	38	kcal	kcal	PROPN
7m01bk15f0h	2	39	/	/	SYM
7m01bk15f0h	2	40	mol	mol	PROPN
7m01bk15f0h	2	41	in	in	ADP
7m01bk15f0h	2	42	presence	presence	NOUN
7m01bk15f0h	2	43	of	of	ADP
7m01bk15f0h	2	44	cofactor	cofactor	NOUN
7m01bk15f0h	2	45	nadh	nadh	PROPN
7m01bk15f0h	2	46	.	.	PUNCT
7m01bk15f0h	3	1	md	md	PROPN
7m01bk15f0h	3	2	simulations	simulation	NOUN
7m01bk15f0h	3	3	performed	perform	VERB
7m01bk15f0h	3	4	using	use	VERB
7m01bk15f0h	3	5	a	a	DET
7m01bk15f0h	3	6	transition	transition	NOUN
7m01bk15f0h	3	7	state	state	NOUN
7m01bk15f0h	3	8	force	force	NOUN
7m01bk15f0h	3	9	field	field	NOUN
7m01bk15f0h	3	10	(	(	PUNCT
7m01bk15f0h	3	11	tsff	tsff	NOUN
7m01bk15f0h	3	12	)	)	PUNCT
7m01bk15f0h	3	13	for	for	ADP
7m01bk15f0h	3	14	this	this	DET
7m01bk15f0h	3	15	reaction	reaction	NOUN
7m01bk15f0h	3	16	show	show	VERB
7m01bk15f0h	3	17	that	that	SCONJ
7m01bk15f0h	3	18	two	two	NUM
7m01bk15f0h	3	19	hydrogen	hydrogen	NOUN
7m01bk15f0h	3	20	bonds	bond	NOUN
7m01bk15f0h	3	21	of	of	ADP
7m01bk15f0h	3	22	the	the	DET
7m01bk15f0h	3	23	nicotinamide	nicotinamide	NOUN
7m01bk15f0h	3	24	and	and	CCONJ
7m01bk15f0h	3	25	ribose	ribose	ADJ
7m01bk15f0h	3	26	moieties	moiety	NOUN
7m01bk15f0h	3	27	of	of	ADP
7m01bk15f0h	3	28	nadh	nadh	NOUN
7m01bk15f0h	3	29	are	be	AUX
7m01bk15f0h	3	30	necessary	necessary	ADJ
7m01bk15f0h	3	31	for	for	ADP
7m01bk15f0h	3	32	maintaining	maintain	VERB
7m01bk15f0h	3	33	the	the	DET
7m01bk15f0h	3	34	ts	ts	ADJ
7m01bk15f0h	3	35	geometry.experimental	geometry.experimental	ADJ
7m01bk15f0h	3	36	studies	study	NOUN
7m01bk15f0h	3	37	of	of	ADP
7m01bk15f0h	3	38	pmhmgr	pmhmgr	NOUN
7m01bk15f0h	3	39	with	with	ADP
7m01bk15f0h	3	40	different	different	ADJ
7m01bk15f0h	3	41	intermediates	intermediate	NOUN
7m01bk15f0h	3	42	are	be	AUX
7m01bk15f0h	3	43	challenging	challenge	VERB
7m01bk15f0h	3	44	because	because	SCONJ
7m01bk15f0h	3	45	the	the	DET
7m01bk15f0h	3	46	optimum	optimum	ADJ
7m01bk15f0h	3	47	activity	activity	NOUN
7m01bk15f0h	3	48	for	for	ADP
7m01bk15f0h	3	49	the	the	DET
7m01bk15f0h	3	50	reductive	reductive	ADJ
7m01bk15f0h	3	51	reaction	reaction	NOUN
7m01bk15f0h	3	52	occurs	occur	VERB
7m01bk15f0h	3	53	at	at	ADP
7m01bk15f0h	3	54	the	the	DET
7m01bk15f0h	3	55	crystallization	crystallization	NOUN
7m01bk15f0h	3	56	ph	ph	NOUN
7m01bk15f0h	3	57	.	.	PUNCT
7m01bk15f0h	4	1	ph	ph	NOUN
7m01bk15f0h	4	2	-	-	PUNCT
7m01bk15f0h	4	3	jump	jump	NOUN
7m01bk15f0h	4	4	experiments	experiment	NOUN
7m01bk15f0h	4	5	have	have	AUX
7m01bk15f0h	4	6	been	be	AUX
7m01bk15f0h	4	7	used	use	VERB
7m01bk15f0h	4	8	to	to	PART
7m01bk15f0h	4	9	obtain	obtain	VERB
7m01bk15f0h	4	10	time	time	NOUN
7m01bk15f0h	4	11	-	-	PUNCT
7m01bk15f0h	4	12	dependent	dependent	ADJ
7m01bk15f0h	4	13	crystal	crystal	NOUN
7m01bk15f0h	4	14	structures	structure	NOUN
7m01bk15f0h	4	15	for	for	ADP
7m01bk15f0h	4	16	the	the	DET
7m01bk15f0h	4	17	oxidative	oxidative	ADJ
7m01bk15f0h	4	18	reaction	reaction	NOUN
7m01bk15f0h	4	19	,	,	PUNCT
7m01bk15f0h	4	20	whose	whose	DET
7m01bk15f0h	4	21	optimum	optimum	ADJ
7m01bk15f0h	4	22	activity	activity	NOUN
7m01bk15f0h	4	23	is	be	AUX
7m01bk15f0h	4	24	at	at	ADP
7m01bk15f0h	4	25	ph	ph	NOUN
7m01bk15f0h	4	26	9	9	NUM
7m01bk15f0h	4	27	.	.	PUNCT
7m01bk15f0h	5	1	all	all	DET
7m01bk15f0h	5	2	-	-	PUNCT
7m01bk15f0h	5	3	atom	atom	NOUN
7m01bk15f0h	5	4	md	md	PROPN
7m01bk15f0h	5	5	simulations	simulation	NOUN
7m01bk15f0h	5	6	were	be	AUX
7m01bk15f0h	5	7	used	use	VERB
7m01bk15f0h	5	8	to	to	PART
7m01bk15f0h	5	9	probe	probe	VERB
7m01bk15f0h	5	10	all	all	DET
7m01bk15f0h	5	11	possible	possible	ADJ
7m01bk15f0h	5	12	protonation	protonation	NOUN
7m01bk15f0h	5	13	states	state	NOUN
7m01bk15f0h	5	14	of	of	ADP
7m01bk15f0h	5	15	catalytic	catalytic	ADJ
7m01bk15f0h	5	16	residues	residue	NOUN
7m01bk15f0h	5	17	to	to	PART
7m01bk15f0h	5	18	investigate	investigate	VERB
7m01bk15f0h	5	19	the	the	DET
7m01bk15f0h	5	20	variations	variation	NOUN
7m01bk15f0h	5	21	in	in	ADP
7m01bk15f0h	5	22	the	the	DET
7m01bk15f0h	5	23	optimum	optimum	ADJ
7m01bk15f0h	5	24	ph	ph	NOUN
7m01bk15f0h	5	25	for	for	ADP
7m01bk15f0h	5	26	the	the	DET
7m01bk15f0h	5	27	reductive	reductive	ADJ
7m01bk15f0h	5	28	and	and	CCONJ
7m01bk15f0h	5	29	oxidative	oxidative	ADJ
7m01bk15f0h	5	30	reactions	reaction	NOUN
7m01bk15f0h	5	31	.	.	PUNCT
7m01bk15f0h	6	1	the	the	DET
7m01bk15f0h	6	2	favorable	favorable	ADJ
7m01bk15f0h	6	3	protonation	protonation	NOUN
7m01bk15f0h	6	4	states	state	NOUN
7m01bk15f0h	6	5	system	system	NOUN
7m01bk15f0h	6	6	,	,	PUNCT
7m01bk15f0h	6	7	in	in	ADP
7m01bk15f0h	6	8	presence	presence	NOUN
7m01bk15f0h	6	9	of	of	ADP
7m01bk15f0h	6	10	mevaldehyde	mevaldehyde	PROPN
7m01bk15f0h	6	11	and	and	CCONJ
7m01bk15f0h	6	12	nadh	nadh	PROPN
7m01bk15f0h	6	13	,	,	PUNCT
7m01bk15f0h	6	14	had	have	VERB
7m01bk15f0h	6	15	a	a	DET
7m01bk15f0h	6	16	positively	positively	ADV
7m01bk15f0h	6	17	charged	charge	VERB
7m01bk15f0h	6	18	his381	his381	PROPN
7m01bk15f0h	6	19	,	,	PUNCT
7m01bk15f0h	6	20	a	a	DET
7m01bk15f0h	6	21	neutral	neutral	ADJ
7m01bk15f0h	6	22	glu83	glu83	NOUN
7m01bk15f0h	6	23	,	,	PUNCT
7m01bk15f0h	6	24	and	and	CCONJ
7m01bk15f0h	6	25	an	an	DET
7m01bk15f0h	6	26	hie	hie	NOUN
7m01bk15f0h	6	27	-	-	PUNCT
7m01bk15f0h	6	28	neutral	neutral	ADJ
7m01bk15f0h	6	29	his385	his385	PROPN
7m01bk15f0h	6	30	.	.	PUNCT
7m01bk15f0h	7	1	a	a	DET
7m01bk15f0h	7	2	photocaged	photocaged	ADJ
7m01bk15f0h	7	3	substrate	substrate	NOUN
7m01bk15f0h	7	4	(	(	PUNCT
7m01bk15f0h	7	5	php	php	ADJ
7m01bk15f0h	7	6	-	-	PUNCT
7m01bk15f0h	7	7	hmg	hmg	NOUN
7m01bk15f0h	7	8	-	-	PUNCT
7m01bk15f0h	7	9	coa	coa	NOUN
7m01bk15f0h	7	10	)	)	PUNCT
7m01bk15f0h	7	11	would	would	AUX
7m01bk15f0h	7	12	also	also	ADV
7m01bk15f0h	7	13	facilitate	facilitate	VERB
7m01bk15f0h	7	14	time	time	NOUN
7m01bk15f0h	7	15	-	-	PUNCT
7m01bk15f0h	7	16	dependent	dependent	ADJ
7m01bk15f0h	7	17	crystallography	crystallography	NOUN
7m01bk15f0h	7	18	by	by	ADP
7m01bk15f0h	7	19	restoring	restore	VERB
7m01bk15f0h	7	20	the	the	DET
7m01bk15f0h	7	21	substrate	substrate	NOUN
7m01bk15f0h	7	22	activity	activity	NOUN
7m01bk15f0h	7	23	after	after	ADP
7m01bk15f0h	7	24	the	the	DET
7m01bk15f0h	7	25	cleavage	cleavage	NOUN
7m01bk15f0h	7	26	of	of	ADP
7m01bk15f0h	7	27	the	the	DET
7m01bk15f0h	7	28	covalently	covalently	ADV
7m01bk15f0h	7	29	bound	bound	ADJ
7m01bk15f0h	7	30	photoprotecting	photoprotecte	VERB
7m01bk15f0h	7	31	group	group	NOUN
7m01bk15f0h	7	32	(	(	PUNCT
7m01bk15f0h	7	33	php	php	PROPN
7m01bk15f0h	7	34	)	)	PUNCT
7m01bk15f0h	7	35	.	.	PUNCT
7m01bk15f0h	8	1	md	md	PROPN
7m01bk15f0h	8	2	simulations	simulation	NOUN
7m01bk15f0h	8	3	performed	perform	VERB
7m01bk15f0h	8	4	on	on	ADP
7m01bk15f0h	8	5	select	select	ADJ
7m01bk15f0h	8	6	binding	bind	VERB
7m01bk15f0h	8	7	poses	pose	NOUN
7m01bk15f0h	8	8	of	of	ADP
7m01bk15f0h	8	9	the	the	DET
7m01bk15f0h	8	10	photocaged	photocaged	ADJ
7m01bk15f0h	8	11	hmg	hmg	NOUN
7m01bk15f0h	8	12	-	-	PUNCT
7m01bk15f0h	8	13	coa	coa	NOUN
7m01bk15f0h	8	14	in	in	ADP
7m01bk15f0h	8	15	pmhmgr	pmhmgr	NOUN
7m01bk15f0h	8	16	,	,	PUNCT
7m01bk15f0h	8	17	in	in	ADP
7m01bk15f0h	8	18	the	the	DET
7m01bk15f0h	8	19	presence	presence	NOUN
7m01bk15f0h	8	20	and	and	CCONJ
7m01bk15f0h	8	21	absence	absence	NOUN
7m01bk15f0h	8	22	of	of	ADP
7m01bk15f0h	8	23	the	the	DET
7m01bk15f0h	8	24	flap	flap	NOUN
7m01bk15f0h	8	25	domain	domain	NOUN
7m01bk15f0h	8	26	,	,	PUNCT
7m01bk15f0h	8	27	show	show	VERB
7m01bk15f0h	8	28	that	that	SCONJ
7m01bk15f0h	8	29	the	the	DET
7m01bk15f0h	8	30	proximity	proximity	NOUN
7m01bk15f0h	8	31	of	of	ADP
7m01bk15f0h	8	32	the	the	DET
7m01bk15f0h	8	33	photocaged	photocaged	ADJ
7m01bk15f0h	8	34	substrate	substrate	NOUN
7m01bk15f0h	8	35	to	to	ADP
7m01bk15f0h	8	36	the	the	DET
7m01bk15f0h	8	37	binding	bind	VERB
7m01bk15f0h	8	38	site	site	NOUN
7m01bk15f0h	8	39	is	be	AUX
7m01bk15f0h	8	40	maintained	maintain	VERB
7m01bk15f0h	8	41	in	in	ADP
7m01bk15f0h	8	42	presence	presence	NOUN
7m01bk15f0h	8	43	of	of	ADP
7m01bk15f0h	8	44	the	the	DET
7m01bk15f0h	8	45	flap	flap	NOUN
7m01bk15f0h	8	46	domain	domain	NOUN
7m01bk15f0h	8	47	.	.	PUNCT
7m01bk15f0h	9	1	this	this	PRON
7m01bk15f0h	9	2	suggests	suggest	VERB
7m01bk15f0h	9	3	soaking	soak	VERB
7m01bk15f0h	9	4	the	the	DET
7m01bk15f0h	9	5	pmhmgr	pmhmgr	NOUN
7m01bk15f0h	9	6	crystals	crystal	NOUN
7m01bk15f0h	9	7	in	in	ADP
7m01bk15f0h	9	8	photocaged	photocaged	ADJ
7m01bk15f0h	9	9	substrate	substrate	NOUN
7m01bk15f0h	9	10	and	and	CCONJ
7m01bk15f0h	9	11	cofactor	cofactor	NOUN
7m01bk15f0h	9	12	since	since	SCONJ
7m01bk15f0h	9	13	the	the	DET
7m01bk15f0h	9	14	flap	flap	NOUN
7m01bk15f0h	9	15	domain	domain	NOUN
7m01bk15f0h	9	16	only	only	ADV
7m01bk15f0h	9	17	closes	close	VERB
7m01bk15f0h	9	18	over	over	ADP
7m01bk15f0h	9	19	the	the	DET
7m01bk15f0h	9	20	active	active	ADJ
7m01bk15f0h	9	21	site	site	NOUN
7m01bk15f0h	9	22	in	in	ADP
7m01bk15f0h	9	23	presence	presence	NOUN
7m01bk15f0h	9	24	of	of	ADP
7m01bk15f0h	9	25	both	both	PRON
7m01bk15f0h	9	26	ligands.to	ligands.to	NUM
7m01bk15f0h	9	27	crystallize	crystallize	NOUN
7m01bk15f0h	9	28	staphylococcus	staphylococcus	PROPN
7m01bk15f0h	9	29	aureus	aureus	PROPN
7m01bk15f0h	9	30	hmgr	hmgr	PROPN
7m01bk15f0h	9	31	,	,	PUNCT
7m01bk15f0h	9	32	its	its	PRON
7m01bk15f0h	9	33	surface	surface	NOUN
7m01bk15f0h	9	34	residues	residue	NOUN
7m01bk15f0h	9	35	were	be	AUX
7m01bk15f0h	9	36	mutated	mutate	VERB
7m01bk15f0h	9	37	guided	guide	VERB
7m01bk15f0h	9	38	by	by	ADP
7m01bk15f0h	9	39	the	the	DET
7m01bk15f0h	9	40	crystal	crystal	NOUN
7m01bk15f0h	9	41	structure	structure	NOUN
7m01bk15f0h	9	42	of	of	ADP
7m01bk15f0h	9	43	efhmgr	efhmgr	PROPN
7m01bk15f0h	9	44	.	.	PUNCT
7m01bk15f0h	10	1	the	the	DET
7m01bk15f0h	10	2	initial	initial	ADJ
7m01bk15f0h	10	3	25	25	NUM
7m01bk15f0h	10	4	aa	aa	NOUN
7m01bk15f0h	10	5	mutant	mutant	NOUN
7m01bk15f0h	10	6	was	be	AUX
7m01bk15f0h	10	7	challenging	challenging	ADJ
7m01bk15f0h	10	8	to	to	PART
7m01bk15f0h	10	9	purify	purify	VERB
7m01bk15f0h	10	10	but	but	CCONJ
7m01bk15f0h	10	11	a	a	DET
7m01bk15f0h	10	12	single	single	ADJ
7m01bk15f0h	10	13	shortened	shorten	VERB
7m01bk15f0h	10	14	loop	loop	NOUN
7m01bk15f0h	10	15	mutant	mutant	NOUN
7m01bk15f0h	10	16	was	be	AUX
7m01bk15f0h	10	17	easier	easy	ADJ
7m01bk15f0h	10	18	to	to	PART
7m01bk15f0h	10	19	purify	purify	VERB
7m01bk15f0h	10	20	and	and	CCONJ
7m01bk15f0h	10	21	was	be	AUX
7m01bk15f0h	10	22	used	use	VERB
7m01bk15f0h	10	23	in	in	ADP
7m01bk15f0h	10	24	crystallization	crystallization	NOUN
7m01bk15f0h	10	25	screening	screen	VERB
7m01bk15f0h	10	26	experiments	experiment	NOUN
7m01bk15f0h	10	27	.	.	PUNCT
7m01bk15f0h	11	1	two	two	NUM
7m01bk15f0h	11	2	other	other	ADJ
7m01bk15f0h	11	3	regional	regional	ADJ
7m01bk15f0h	11	4	mutants	mutant	NOUN
7m01bk15f0h	11	5	were	be	AUX
7m01bk15f0h	11	6	suggested	suggest	VERB
7m01bk15f0h	11	7	and	and	CCONJ
7m01bk15f0h	11	8	are	be	AUX
7m01bk15f0h	11	9	currently	currently	ADV
7m01bk15f0h	11	10	being	be	AUX
7m01bk15f0h	11	11	investigated	investigate	VERB
7m01bk15f0h	11	12	in	in	ADP
7m01bk15f0h	11	13	the	the	DET
7m01bk15f0h	11	14	stauffacher	stauffacher	NOUN
7m01bk15f0h	11	15	lab	lab	NOUN
7m01bk15f0h	11	16	at	at	ADP
7m01bk15f0h	11	17	purdue	purdue	ADJ
7m01bk15f0h	11	18	university.stabilized	university.stabilized	ADJ
7m01bk15f0h	11	19	helices	helix	NOUN
7m01bk15f0h	11	20	have	have	AUX
7m01bk15f0h	11	21	been	be	AUX
7m01bk15f0h	11	22	used	use	VERB
7m01bk15f0h	11	23	to	to	PART
7m01bk15f0h	11	24	target	target	VERB
7m01bk15f0h	11	25	protein	protein	NOUN
7m01bk15f0h	11	26	-	-	PUNCT
7m01bk15f0h	11	27	protein	protein	NOUN
7m01bk15f0h	11	28	interactions	interaction	NOUN
7m01bk15f0h	11	29	in	in	ADP
7m01bk15f0h	11	30	biomolecular	biomolecular	ADJ
7m01bk15f0h	11	31	systems	system	NOUN
7m01bk15f0h	11	32	.	.	PUNCT
7m01bk15f0h	12	1	classical	classical	ADJ
7m01bk15f0h	12	2	md	md	PROPN
7m01bk15f0h	12	3	simulations	simulation	NOUN
7m01bk15f0h	12	4	of	of	ADP
7m01bk15f0h	12	5	n	n	ADJ
7m01bk15f0h	12	6	-	-	PUNCT
7m01bk15f0h	12	7	aminated	aminated	ADJ
7m01bk15f0h	12	8	peptides	peptide	NOUN
7m01bk15f0h	12	9	at	at	ADP
7m01bk15f0h	12	10	the	the	DET
7m01bk15f0h	12	11	evp40	evp40	PROPN
7m01bk15f0h	12	12	dimeric	dimeric	ADJ
7m01bk15f0h	12	13	interface	interface	NOUN
7m01bk15f0h	12	14	show	show	VERB
7m01bk15f0h	12	15	conservation	conservation	NOUN
7m01bk15f0h	12	16	of	of	ADP
7m01bk15f0h	12	17	helicity	helicity	NOUN
7m01bk15f0h	12	18	in	in	ADP
7m01bk15f0h	12	19	~4	~4	ADJ
7m01bk15f0h	12	20	hydrophobic	hydrophobic	NOUN
7m01bk15f0h	12	21	residues	residue	NOUN
7m01bk15f0h	12	22	at	at	ADP
7m01bk15f0h	12	23	the	the	DET
7m01bk15f0h	12	24	center	center	NOUN
7m01bk15f0h	12	25	of	of	ADP
7m01bk15f0h	12	26	the	the	DET
7m01bk15f0h	12	27	stabilized	stabilize	VERB
7m01bk15f0h	12	28	helix.engineering	helix.engineere	VERB
7m01bk15f0h	12	29	large	large	ADJ
7m01bk15f0h	12	30	proteins	protein	NOUN
7m01bk15f0h	12	31	such	such	ADJ
7m01bk15f0h	12	32	as	as	ADP
7m01bk15f0h	12	33	spcas9	spcas9	NOUN
7m01bk15f0h	12	34	in	in	SCONJ
7m01bk15f0h	12	35	order	order	NOUN
7m01bk15f0h	12	36	to	to	PART
7m01bk15f0h	12	37	add	add	VERB
7m01bk15f0h	12	38	functionality	functionality	NOUN
7m01bk15f0h	12	39	through	through	ADP
7m01bk15f0h	12	40	domain	domain	NOUN
7m01bk15f0h	12	41	insertions	insertion	NOUN
7m01bk15f0h	12	42	is	be	AUX
7m01bk15f0h	12	43	of	of	ADP
7m01bk15f0h	12	44	great	great	ADJ
7m01bk15f0h	12	45	interest	interest	NOUN
7m01bk15f0h	12	46	albeit	albeit	SCONJ
7m01bk15f0h	12	47	a	a	DET
7m01bk15f0h	12	48	labor	labor	NOUN
7m01bk15f0h	12	49	-	-	PUNCT
7m01bk15f0h	12	50	intensive	intensive	ADJ
7m01bk15f0h	12	51	process	process	NOUN
7m01bk15f0h	12	52	.	.	PUNCT
7m01bk15f0h	13	1	rmsf	rmsf	ADJ
7m01bk15f0h	13	2	analysis	analysis	NOUN
7m01bk15f0h	13	3	from	from	ADP
7m01bk15f0h	13	4	long	long	ADJ
7m01bk15f0h	13	5	timescale	timescale	NOUN
7m01bk15f0h	13	6	(	(	PUNCT
7m01bk15f0h	13	7	1	1	NUM
7m01bk15f0h	13	8	μs	μs	NUM
7m01bk15f0h	13	9	)	)	PUNCT
7m01bk15f0h	13	10	all	all	DET
7m01bk15f0h	13	11	-	-	PUNCT
7m01bk15f0h	13	12	atom	atom	NOUN
7m01bk15f0h	13	13	md	md	PROPN
7m01bk15f0h	13	14	simulations	simulation	NOUN
7m01bk15f0h	13	15	shows	show	VERB
7m01bk15f0h	13	16	a	a	DET
7m01bk15f0h	13	17	good	good	ADJ
7m01bk15f0h	13	18	correlation	correlation	NOUN
7m01bk15f0h	13	19	to	to	ADP
7m01bk15f0h	13	20	the	the	DET
7m01bk15f0h	13	21	experimental	experimental	ADJ
7m01bk15f0h	13	22	domain	domain	NOUN
7m01bk15f0h	13	23	insertion	insertion	NOUN
7m01bk15f0h	13	24	hotspots	hotspot	NOUN
7m01bk15f0h	13	25	.	.	PUNCT
7m01bk15f0h	14	1	this	this	PRON
7m01bk15f0h	14	2	indicates	indicate	VERB
7m01bk15f0h	14	3	that	that	SCONJ
7m01bk15f0h	14	4	md	md	PROPN
7m01bk15f0h	14	5	simulations	simulation	NOUN
7m01bk15f0h	14	6	can	can	AUX
7m01bk15f0h	14	7	be	be	AUX
7m01bk15f0h	14	8	used	use	VERB
7m01bk15f0h	14	9	to	to	PART
7m01bk15f0h	14	10	guide	guide	VERB
7m01bk15f0h	14	11	protein	protein	NOUN
7m01bk15f0h	14	12	engineering	engineering	NOUN
7m01bk15f0h	14	13	.	.	PUNCT