id sid tid token lemma pos 79407w64f6h 1 1 mycobacteria mycobacteria PROPN 79407w64f6h 1 2 are be AUX 79407w64f6h 1 3 intracellular intracellular ADJ 79407w64f6h 1 4 pathogens pathogen NOUN 79407w64f6h 1 5 that that PRON 79407w64f6h 1 6 are be AUX 79407w64f6h 1 7 capable capable ADJ 79407w64f6h 1 8 of of ADP 79407w64f6h 1 9 surviving survive VERB 79407w64f6h 1 10 and and CCONJ 79407w64f6h 1 11 persisting persist VERB 79407w64f6h 1 12 within within ADP 79407w64f6h 1 13 host host NOUN 79407w64f6h 1 14 macrophages macrophage NOUN 79407w64f6h 1 15 by by ADP 79407w64f6h 1 16 using use VERB 79407w64f6h 1 17 sophisticated sophisticated ADJ 79407w64f6h 1 18 evasion evasion NOUN 79407w64f6h 1 19 strategies strategy NOUN 79407w64f6h 1 20 . . PUNCT 79407w64f6h 2 1 one one NUM 79407w64f6h 2 2 of of ADP 79407w64f6h 2 3 the the DET 79407w64f6h 2 4 most most ADV 79407w64f6h 2 5 intriguing intriguing ADJ 79407w64f6h 2 6 questions question NOUN 79407w64f6h 2 7 in in ADP 79407w64f6h 2 8 mycobacterial mycobacterial ADJ 79407w64f6h 2 9 pathogenesis pathogenesis NOUN 79407w64f6h 2 10 concerns concern VERB 79407w64f6h 2 11 the the DET 79407w64f6h 2 12 initial initial ADJ 79407w64f6h 2 13 interaction interaction NOUN 79407w64f6h 2 14 between between ADP 79407w64f6h 2 15 mycobacteria mycobacteria NOUN 79407w64f6h 2 16 and and CCONJ 79407w64f6h 2 17 host host NOUN 79407w64f6h 2 18 macrophage macrophage NOUN 79407w64f6h 2 19 and and CCONJ 79407w64f6h 2 20 how how SCONJ 79407w64f6h 2 21 mycobacteria mycobacteria PROPN 79407w64f6h 2 22 modulate modulate VERB 79407w64f6h 2 23 the the DET 79407w64f6h 2 24 macrophage macrophage NOUN 79407w64f6h 2 25 signaling signal VERB 79407w64f6h 2 26 response response NOUN 79407w64f6h 2 27 . . PUNCT 79407w64f6h 3 1 interestingly interestingly ADV 79407w64f6h 3 2 infection infection NOUN 79407w64f6h 3 3 with with ADP 79407w64f6h 3 4 pathogenic pathogenic ADJ 79407w64f6h 3 5 strains strain NOUN 79407w64f6h 3 6 of of ADP 79407w64f6h 3 7 m. m. NOUN 79407w64f6h 3 8 avium avium NOUN 79407w64f6h 3 9 results result NOUN 79407w64f6h 3 10 in in ADP 79407w64f6h 3 11 diminished diminished ADJ 79407w64f6h 3 12 activation activation NOUN 79407w64f6h 3 13 of of ADP 79407w64f6h 3 14 p38 p38 NOUN 79407w64f6h 3 15 and and CCONJ 79407w64f6h 3 16 erk1/2 erk1/2 VERB 79407w64f6h 3 17 in in ADP 79407w64f6h 3 18 macrophages macrophage NOUN 79407w64f6h 3 19 compared compare VERB 79407w64f6h 3 20 to to ADP 79407w64f6h 3 21 infections infection NOUN 79407w64f6h 3 22 with with ADP 79407w64f6h 3 23 the the DET 79407w64f6h 3 24 fast fast ADV 79407w64f6h 3 25 - - PUNCT 79407w64f6h 3 26 growing grow VERB 79407w64f6h 3 27 , , PUNCT 79407w64f6h 3 28 non non ADJ 79407w64f6h 3 29 - - ADJ 79407w64f6h 3 30 pathogenic pathogenic ADJ 79407w64f6h 3 31 m. m. NOUN 79407w64f6h 3 32 smegmatis smegmatis PROPN 79407w64f6h 3 33 and and CCONJ 79407w64f6h 3 34 m. m. PROPN 79407w64f6h 3 35 phlei phlei PROPN 79407w64f6h 3 36 . . PUNCT 79407w64f6h 4 1 however however ADV 79407w64f6h 4 2 , , PUNCT 79407w64f6h 4 3 the the DET 79407w64f6h 4 4 upstream upstream ADJ 79407w64f6h 4 5 signals signal NOUN 79407w64f6h 4 6 required require VERB 79407w64f6h 4 7 for for ADP 79407w64f6h 4 8 mapk mapk NOUN 79407w64f6h 4 9 activation activation NOUN 79407w64f6h 4 10 and and CCONJ 79407w64f6h 4 11 the the DET 79407w64f6h 4 12 mechanisms mechanism NOUN 79407w64f6h 4 13 behind behind ADP 79407w64f6h 4 14 the the DET 79407w64f6h 4 15 differential differential ADJ 79407w64f6h 4 16 activation activation NOUN 79407w64f6h 4 17 of of ADP 79407w64f6h 4 18 the the DET 79407w64f6h 4 19 mapks mapks NOUN 79407w64f6h 4 20 remain remain VERB 79407w64f6h 4 21 undefined undefined ADJ 79407w64f6h 4 22 . . PUNCT 79407w64f6h 5 1 in in ADP 79407w64f6h 5 2 this this DET 79407w64f6h 5 3 study study NOUN 79407w64f6h 5 4 , , PUNCT 79407w64f6h 5 5 using use VERB 79407w64f6h 5 6 bone bone NOUN 79407w64f6h 5 7 marrow marrow NOUN 79407w64f6h 5 8 - - PUNCT 79407w64f6h 5 9 derived derive VERB 79407w64f6h 5 10 macrophages macrophage NOUN 79407w64f6h 5 11 ( ( PUNCT 79407w64f6h 5 12 bmmµð bmmµð NOUN 79407w64f6h 5 13 ) ) PUNCT 79407w64f6h 5 14 , , PUNCT 79407w64f6h 5 15 we we PRON 79407w64f6h 5 16 determined determine VERB 79407w64f6h 5 17 that that SCONJ 79407w64f6h 5 18 erk1/2 erk1/2 ADJ 79407w64f6h 5 19 activation activation NOUN 79407w64f6h 5 20 following follow VERB 79407w64f6h 5 21 mycobacterial mycobacterial ADJ 79407w64f6h 5 22 infection infection NOUN 79407w64f6h 5 23 is be AUX 79407w64f6h 5 24 dependent dependent ADJ 79407w64f6h 5 25 on on ADP 79407w64f6h 5 26 ca2 ca2 SPACE 79407w64f6h 5 27 + + NOUN 79407w64f6h 5 28 and and CCONJ 79407w64f6h 5 29 sphingosine sphingosine NOUN 79407w64f6h 5 30 kinase kinase NOUN 79407w64f6h 5 31 ( ( PUNCT 79407w64f6h 5 32 spk spk PROPN 79407w64f6h 5 33 ) ) PUNCT 79407w64f6h 5 34 activation activation NOUN 79407w64f6h 5 35 . . PUNCT 79407w64f6h 6 1 interestingly interestingly ADV 79407w64f6h 6 2 , , PUNCT 79407w64f6h 6 3 in in ADP 79407w64f6h 6 4 bmmµð bmmµð NOUN 79407w64f6h 6 5 infected infect VERB 79407w64f6h 6 6 with with ADP 79407w64f6h 6 7 m. m. NOUN 79407w64f6h 6 8 smegmatis smegmatis PROPN 79407w64f6h 6 9 compared compare VERB 79407w64f6h 6 10 to to ADP 79407w64f6h 6 11 m. m. NOUN 79407w64f6h 6 12 avium avium NOUN 79407w64f6h 6 13 , , PUNCT 79407w64f6h 6 14 there there PRON 79407w64f6h 6 15 is be VERB 79407w64f6h 6 16 sustained sustained ADJ 79407w64f6h 6 17 activation activation NOUN 79407w64f6h 6 18 of of ADP 79407w64f6h 6 19 ca2+/cam ca2+/cam ADJ 79407w64f6h 6 20 dependent dependent ADJ 79407w64f6h 6 21 camkii camkii NOUN 79407w64f6h 6 22 , , PUNCT 79407w64f6h 6 23 which which PRON 79407w64f6h 6 24 through through ADP 79407w64f6h 6 25 induction induction NOUN 79407w64f6h 6 26 of of ADP 79407w64f6h 6 27 camp camp NOUN 79407w64f6h 6 28 results result NOUN 79407w64f6h 6 29 in in ADP 79407w64f6h 6 30 increased increase VERB 79407w64f6h 6 31 erk1/2 erk1/2 ADJ 79407w64f6h 6 32 activation activation NOUN 79407w64f6h 6 33 and and CCONJ 79407w64f6h 6 34 tnf-µô tnf-µô PROPN 79407w64f6h 6 35 production production NOUN 79407w64f6h 6 36 . . PUNCT 79407w64f6h 7 1 however however ADV 79407w64f6h 7 2 , , PUNCT 79407w64f6h 7 3 low low ADJ 79407w64f6h 7 4 tnf-µô tnf-µô PROPN 79407w64f6h 7 5 production production NOUN 79407w64f6h 7 6 in in ADP 79407w64f6h 7 7 m. m. NOUN 79407w64f6h 7 8 avium avium NOUN 79407w64f6h 7 9 infected infect VERB 79407w64f6h 7 10 bmmµð bmmµð PROPN 79407w64f6h 7 11 is be AUX 79407w64f6h 7 12 independent independent ADJ 79407w64f6h 7 13 of of ADP 79407w64f6h 7 14 these these DET 79407w64f6h 7 15 pathways pathway NOUN 79407w64f6h 7 16 . . PUNCT 79407w64f6h 8 1 furthermore furthermore ADV 79407w64f6h 8 2 , , PUNCT 79407w64f6h 8 3 there there PRON 79407w64f6h 8 4 was be VERB 79407w64f6h 8 5 increased increase VERB 79407w64f6h 8 6 activation activation NOUN 79407w64f6h 8 7 of of ADP 79407w64f6h 8 8 conventional conventional ADJ 79407w64f6h 8 9 pkc pkc ADJ 79407w64f6h 8 10 isoforms isoform NOUN 79407w64f6h 8 11 ( ( PUNCT 79407w64f6h 8 12 cpkc cpkc PROPN 79407w64f6h 8 13 ) ) PUNCT 79407w64f6h 8 14 and and CCONJ 79407w64f6h 8 15 pi-3 pi-3 PROPN 79407w64f6h 8 16 kinase kinase NOUN 79407w64f6h 8 17 in in ADP 79407w64f6h 8 18 bmmµð bmmµð NOUN 79407w64f6h 8 19 infected infect VERB 79407w64f6h 8 20 with with ADP 79407w64f6h 8 21 m. m. NOUN 79407w64f6h 8 22 smegmatis smegmatis PROPN 79407w64f6h 8 23 compared compare VERB 79407w64f6h 8 24 to to ADP 79407w64f6h 8 25 m. m. NOUN 79407w64f6h 8 26 avium avium NOUN 79407w64f6h 8 27 . . PUNCT 79407w64f6h 9 1 this this DET 79407w64f6h 9 2 cpkc cpkc NOUN 79407w64f6h 9 3 and and CCONJ 79407w64f6h 9 4 pi-3 pi-3 PROPN 79407w64f6h 9 5 kinase kinase ADJ 79407w64f6h 9 6 activation activation NOUN 79407w64f6h 9 7 was be AUX 79407w64f6h 9 8 also also ADV 79407w64f6h 9 9 dependent dependent ADJ 79407w64f6h 9 10 on on ADP 79407w64f6h 9 11 spk spk PROPN 79407w64f6h 9 12 and and CCONJ 79407w64f6h 9 13 pi pi PROPN 79407w64f6h 9 14 - - PUNCT 79407w64f6h 9 15 plc plc PROPN 79407w64f6h 9 16 . . PUNCT 79407w64f6h 10 1 finally finally ADV 79407w64f6h 10 2 , , PUNCT 79407w64f6h 10 3 in in ADP 79407w64f6h 10 4 bmmµð bmmµð NOUN 79407w64f6h 10 5 infected infect VERB 79407w64f6h 10 6 with with ADP 79407w64f6h 10 7 m. m. NOUN 79407w64f6h 10 8 smegmatis smegmatis PROPN 79407w64f6h 10 9 compared compare VERB 79407w64f6h 10 10 to to ADP 79407w64f6h 10 11 m. m. NOUN 79407w64f6h 10 12 avium avium NOUN 79407w64f6h 10 13 , , PUNCT 79407w64f6h 10 14 we we PRON 79407w64f6h 10 15 observed observe VERB 79407w64f6h 10 16 enhanced enhanced ADJ 79407w64f6h 10 17 secretion secretion NOUN 79407w64f6h 10 18 of of ADP 79407w64f6h 10 19 tnf-µô tnf-µô PROPN 79407w64f6h 10 20 , , PUNCT 79407w64f6h 10 21 il-6 il-6 SPACE 79407w64f6h 10 22 , , PUNCT 79407w64f6h 10 23 rantes rante NOUN 79407w64f6h 10 24 and and CCONJ 79407w64f6h 10 25 g g NOUN 79407w64f6h 10 26 - - PUNCT 79407w64f6h 10 27 csf csf NOUN 79407w64f6h 10 28 , , PUNCT 79407w64f6h 10 29 which which PRON 79407w64f6h 10 30 is be AUX 79407w64f6h 10 31 dependent dependent ADJ 79407w64f6h 10 32 on on ADP 79407w64f6h 10 33 spk spk PROPN 79407w64f6h 10 34 , , PUNCT 79407w64f6h 10 35 pi pi PROPN 79407w64f6h 10 36 - - PUNCT 79407w64f6h 10 37 plc plc PROPN 79407w64f6h 10 38 , , PUNCT 79407w64f6h 10 39 cpkc cpkc NOUN 79407w64f6h 10 40 and and CCONJ 79407w64f6h 10 41 pi-3 pi-3 PROPN 79407w64f6h 10 42 kinase kinase NOUN 79407w64f6h 10 43 . . PUNCT 79407w64f6h 11 1 we we PRON 79407w64f6h 11 2 then then ADV 79407w64f6h 11 3 initiated initiate VERB 79407w64f6h 11 4 experiments experiment NOUN 79407w64f6h 11 5 using use VERB 79407w64f6h 11 6 receptor receptor NOUN 79407w64f6h 11 7 knockout knockout NOUN 79407w64f6h 11 8 macrophages macrophage NOUN 79407w64f6h 11 9 to to PART 79407w64f6h 11 10 determine determine VERB 79407w64f6h 11 11 the the DET 79407w64f6h 11 12 role role NOUN 79407w64f6h 11 13 of of ADP 79407w64f6h 11 14 different different ADJ 79407w64f6h 11 15 macrophage macrophage NOUN 79407w64f6h 11 16 pattern pattern NOUN 79407w64f6h 11 17 recognition recognition NOUN 79407w64f6h 11 18 receptors receptor NOUN 79407w64f6h 11 19 ( ( PUNCT 79407w64f6h 11 20 prr prr PROPN 79407w64f6h 11 21 ) ) PUNCT 79407w64f6h 11 22 in in ADP 79407w64f6h 11 23 the the DET 79407w64f6h 11 24 induction induction NOUN 79407w64f6h 11 25 of of ADP 79407w64f6h 11 26 macrophage macrophage NOUN 79407w64f6h 11 27 pro pro ADJ 79407w64f6h 11 28 - - ADJ 79407w64f6h 11 29 inflammatory inflammatory ADJ 79407w64f6h 11 30 response response NOUN 79407w64f6h 11 31 . . PUNCT 79407w64f6h 12 1 we we PRON 79407w64f6h 12 2 observed observe VERB 79407w64f6h 12 3 that that SCONJ 79407w64f6h 12 4 mannose mannose NOUN 79407w64f6h 12 5 receptor receptor NOUN 79407w64f6h 12 6 is be AUX 79407w64f6h 12 7 not not PART 79407w64f6h 12 8 required require VERB 79407w64f6h 12 9 for for ADP 79407w64f6h 12 10 mycobacterial mycobacterial ADJ 79407w64f6h 12 11 phagocytosis phagocytosis NOUN 79407w64f6h 12 12 or or CCONJ 79407w64f6h 12 13 for for ADP 79407w64f6h 12 14 macrophage macrophage NOUN 79407w64f6h 12 15 activation activation NOUN 79407w64f6h 12 16 . . PUNCT 79407w64f6h 13 1 additional additional ADJ 79407w64f6h 13 2 analysis analysis NOUN 79407w64f6h 13 3 showed show VERB 79407w64f6h 13 4 that that SCONJ 79407w64f6h 13 5 mapk mapk PROPN 79407w64f6h 13 6 activation activation NOUN 79407w64f6h 13 7 and and CCONJ 79407w64f6h 13 8 tnf-µô tnf-µô PROPN 79407w64f6h 13 9 production production NOUN 79407w64f6h 13 10 in in ADP 79407w64f6h 13 11 macrophage macrophage NOUN 79407w64f6h 13 12 infected infect VERB 79407w64f6h 13 13 with with ADP 79407w64f6h 13 14 m. m. NOUN 79407w64f6h 13 15 avium avium NOUN 79407w64f6h 13 16 or or CCONJ 79407w64f6h 13 17 m. m. NOUN 79407w64f6h 13 18 smegmatis smegmatis PROPN 79407w64f6h 13 19 is be AUX 79407w64f6h 13 20 dependent dependent ADJ 79407w64f6h 13 21 on on ADP 79407w64f6h 13 22 myd88 myd88 PROPN 79407w64f6h 13 23 and and CCONJ 79407w64f6h 13 24 tlr2 tlr2 NOUN 79407w64f6h 13 25 ( ( PUNCT 79407w64f6h 13 26 toll toll NOUN 79407w64f6h 13 27 - - PUNCT 79407w64f6h 13 28 like like ADJ 79407w64f6h 13 29 receptor receptor NOUN 79407w64f6h 13 30 2 2 NUM 79407w64f6h 13 31 ) ) PUNCT 79407w64f6h 13 32 but but CCONJ 79407w64f6h 13 33 not not PART 79407w64f6h 13 34 tlr4 tlr4 ADJ 79407w64f6h 13 35 . . PUNCT 79407w64f6h 14 1 however however ADV 79407w64f6h 14 2 , , PUNCT 79407w64f6h 14 3 the the DET 79407w64f6h 14 4 tlr2 tlr2 NOUN 79407w64f6h 14 5 mediated mediate VERB 79407w64f6h 14 6 production production NOUN 79407w64f6h 14 7 of of ADP 79407w64f6h 14 8 tnf-µô tnf-µô PROPN 79407w64f6h 14 9 by by ADP 79407w64f6h 14 10 m. m. NOUN 79407w64f6h 14 11 smegmatis smegmatis PROPN 79407w64f6h 14 12 infected infect VERB 79407w64f6h 14 13 macrophages macrophage NOUN 79407w64f6h 14 14 was be AUX 79407w64f6h 14 15 dependent dependent ADJ 79407w64f6h 14 16 on on ADP 79407w64f6h 14 17 the the DET 79407w64f6h 14 18 µõ µõ PROPN 79407w64f6h 14 19 - - PUNCT 79407w64f6h 14 20 glucan glucan PROPN 79407w64f6h 14 21 receptor receptor NOUN 79407w64f6h 14 22 dectin-1 dectin-1 PROPN 79407w64f6h 14 23 . . PUNCT 79407w64f6h 15 1 a a DET 79407w64f6h 15 2 similar similar ADJ 79407w64f6h 15 3 requirement requirement NOUN 79407w64f6h 15 4 for for ADP 79407w64f6h 15 5 dectin-1 dectin-1 PROPN 79407w64f6h 15 6 in in ADP 79407w64f6h 15 7 tnf-µô tnf-µô PROPN 79407w64f6h 15 8 production production NOUN 79407w64f6h 15 9 was be AUX 79407w64f6h 15 10 observed observe VERB 79407w64f6h 15 11 for for ADP 79407w64f6h 15 12 macrophages macrophage NOUN 79407w64f6h 15 13 infected infect VERB 79407w64f6h 15 14 with with ADP 79407w64f6h 15 15 m. m. PROPN 79407w64f6h 15 16 bovis bovis PROPN 79407w64f6h 15 17 bcg bcg PROPN 79407w64f6h 15 18 and and CCONJ 79407w64f6h 15 19 m. m. NOUN 79407w64f6h 15 20 phlei phlei PROPN 79407w64f6h 15 21 . . PUNCT 79407w64f6h 16 1 furthermore furthermore ADV 79407w64f6h 16 2 , , PUNCT 79407w64f6h 16 3 il-6 il-6 SPACE 79407w64f6h 16 4 , , PUNCT 79407w64f6h 16 5 g g PROPN 79407w64f6h 16 6 - - PUNCT 79407w64f6h 16 7 csf csf NOUN 79407w64f6h 16 8 and and CCONJ 79407w64f6h 16 9 rantes rant VERB 79407w64f6h 16 10 production production NOUN 79407w64f6h 16 11 by by ADP 79407w64f6h 16 12 mycobacteria mycobacteria NOUN 79407w64f6h 16 13 infected infect VERB 79407w64f6h 16 14 macrophages macrophage NOUN 79407w64f6h 16 15 required require VERB 79407w64f6h 16 16 dectin-1 dectin-1 PROPN 79407w64f6h 16 17 . . PROPN 79407w64f6h 17 1 in in ADP 79407w64f6h 17 2 conclusion conclusion NOUN 79407w64f6h 17 3 , , PUNCT 79407w64f6h 17 4 our our PRON 79407w64f6h 17 5 data datum NOUN 79407w64f6h 17 6 clearly clearly ADV 79407w64f6h 17 7 demonstrate demonstrate VERB 79407w64f6h 17 8 that that SCONJ 79407w64f6h 17 9 multiple multiple ADJ 79407w64f6h 17 10 signaling signal VERB 79407w64f6h 17 11 pathways pathway NOUN 79407w64f6h 17 12 are be AUX 79407w64f6h 17 13 targeted target VERB 79407w64f6h 17 14 by by ADP 79407w64f6h 17 15 mycobacteria mycobacterium NOUN 79407w64f6h 17 16 to to PART 79407w64f6h 17 17 induce induce VERB 79407w64f6h 17 18 a a DET 79407w64f6h 17 19 differential differential ADJ 79407w64f6h 17 20 pro pro ADJ 79407w64f6h 17 21 - - ADJ 79407w64f6h 17 22 inflammatory inflammatory ADJ 79407w64f6h 17 23 response response NOUN 79407w64f6h 17 24 in in ADP 79407w64f6h 17 25 macrophages macrophage NOUN 79407w64f6h 17 26 and and CCONJ 79407w64f6h 17 27 importantly importantly ADV 79407w64f6h 17 28 this this DET 79407w64f6h 17 29 difference difference NOUN 79407w64f6h 17 30 is be AUX 79407w64f6h 17 31 due due ADJ 79407w64f6h 17 32 to to ADP 79407w64f6h 17 33 the the DET 79407w64f6h 17 34 qualitative qualitative ADJ 79407w64f6h 17 35 and and CCONJ 79407w64f6h 17 36 quantitative quantitative ADJ 79407w64f6h 17 37 differences difference NOUN 79407w64f6h 17 38 in in ADP 79407w64f6h 17 39 the the DET 79407w64f6h 17 40 stimulation stimulation NOUN 79407w64f6h 17 41 of of ADP 79407w64f6h 17 42 macrophage macrophage NOUN 79407w64f6h 17 43 receptors receptor NOUN 79407w64f6h 17 44 by by ADP 79407w64f6h 17 45 pathogenic pathogenic ADJ 79407w64f6h 17 46 and and CCONJ 79407w64f6h 17 47 non non ADJ 79407w64f6h 17 48 - - ADJ 79407w64f6h 17 49 pathogenic pathogenic ADJ 79407w64f6h 17 50 mycobacteria mycobacterium NOUN 79407w64f6h 17 51 . . PUNCT