id	sid	tid	token	lemma	pos
70795715p9f	1	1	in	in	ADP
70795715p9f	1	2	the	the	DET
70795715p9f	1	3	united	united	PROPN
70795715p9f	1	4	states	states	PROPN
70795715p9f	1	5	,	,	PUNCT
70795715p9f	1	6	according	accord	VERB
70795715p9f	1	7	to	to	ADP
70795715p9f	1	8	the	the	DET
70795715p9f	1	9	american	american	ADJ
70795715p9f	1	10	cancer	cancer	NOUN
70795715p9f	1	11	society	society	NOUN
70795715p9f	1	12	,	,	PUNCT
70795715p9f	1	13	608,570	608,570	NUM
70795715p9f	1	14	cancer	cancer	NOUN
70795715p9f	1	15	deaths	death	NOUN
70795715p9f	1	16	are	be	AUX
70795715p9f	1	17	projected	project	VERB
70795715p9f	1	18	to	to	PART
70795715p9f	1	19	occur	occur	VERB
70795715p9f	1	20	among	among	ADP
70795715p9f	1	21	men	man	NOUN
70795715p9f	1	22	and	and	CCONJ
70795715p9f	1	23	women	woman	NOUN
70795715p9f	1	24	in	in	ADP
70795715p9f	1	25	2021	2021	NUM
70795715p9f	1	26	.	.	PUNCT
70795715p9f	2	1	astonishingly	astonishingly	ADV
70795715p9f	2	2	,	,	PUNCT
70795715p9f	2	3	toward	toward	ADP
70795715p9f	2	4	the	the	DET
70795715p9f	2	5	end	end	NOUN
70795715p9f	2	6	of	of	ADP
70795715p9f	2	7	the	the	DET
70795715p9f	2	8	20th	20th	ADJ
70795715p9f	2	9	century	century	NOUN
70795715p9f	2	10	,	,	PUNCT
70795715p9f	2	11	the	the	DET
70795715p9f	2	12	cancer	cancer	NOUN
70795715p9f	2	13	death	death	NOUN
70795715p9f	2	14	rate	rate	NOUN
70795715p9f	2	15	began	begin	VERB
70795715p9f	2	16	continuously	continuously	ADV
70795715p9f	2	17	falling	fall	VERB
70795715p9f	2	18	from	from	ADP
70795715p9f	2	19	its	its	PRON
70795715p9f	2	20	height	height	NOUN
70795715p9f	2	21	in	in	ADP
70795715p9f	2	22	1991	1991	NUM
70795715p9f	2	23	through	through	ADP
70795715p9f	2	24	2018	2018	NUM
70795715p9f	2	25	,	,	PUNCT
70795715p9f	2	26	for	for	ADP
70795715p9f	2	27	a	a	DET
70795715p9f	2	28	total	total	ADJ
70795715p9f	2	29	decline	decline	NOUN
70795715p9f	2	30	of	of	ADP
70795715p9f	2	31	31	31	NUM
70795715p9f	2	32	%	%	NOUN
70795715p9f	2	33	.	.	PUNCT
70795715p9f	3	1	this	this	DET
70795715p9f	3	2	steady	steady	ADJ
70795715p9f	3	3	decline	decline	NOUN
70795715p9f	3	4	in	in	ADP
70795715p9f	3	5	cancer	cancer	NOUN
70795715p9f	3	6	death	death	NOUN
70795715p9f	3	7	is	be	AUX
70795715p9f	3	8	indubitably	indubitably	ADV
70795715p9f	3	9	reflective	reflective	ADJ
70795715p9f	3	10	of	of	ADP
70795715p9f	3	11	a	a	DET
70795715p9f	3	12	multi	multi	ADJ
70795715p9f	3	13	-	-	ADJ
70795715p9f	3	14	faceted	faceted	ADJ
70795715p9f	3	15	effort	effort	NOUN
70795715p9f	3	16	in	in	ADP
70795715p9f	3	17	understanding	understand	VERB
70795715p9f	3	18	the	the	DET
70795715p9f	3	19	basic	basic	ADJ
70795715p9f	3	20	biology	biology	NOUN
70795715p9f	3	21	of	of	ADP
70795715p9f	3	22	cancer	cancer	NOUN
70795715p9f	3	23	and	and	CCONJ
70795715p9f	3	24	developing	develop	VERB
70795715p9f	3	25	effective	effective	ADJ
70795715p9f	3	26	therapeutic	therapeutic	ADJ
70795715p9f	3	27	strategies	strategy	NOUN
70795715p9f	3	28	.	.	PUNCT
70795715p9f	4	1	therefore	therefore	ADV
70795715p9f	4	2	,	,	PUNCT
70795715p9f	4	3	to	to	PART
70795715p9f	4	4	persist	persist	VERB
70795715p9f	4	5	down	down	ADP
70795715p9f	4	6	the	the	DET
70795715p9f	4	7	path	path	NOUN
70795715p9f	4	8	of	of	ADP
70795715p9f	4	9	decreasing	decrease	VERB
70795715p9f	4	10	cancer	cancer	NOUN
70795715p9f	4	11	death	death	NOUN
70795715p9f	4	12	rates	rate	NOUN
70795715p9f	4	13	,	,	PUNCT
70795715p9f	4	14	investigations	investigation	NOUN
70795715p9f	4	15	into	into	ADP
70795715p9f	4	16	one	one	NUM
70795715p9f	4	17	of	of	ADP
70795715p9f	4	18	the	the	DET
70795715p9f	4	19	most	most	ADV
70795715p9f	4	20	prominent	prominent	ADJ
70795715p9f	4	21	causes	cause	NOUN
70795715p9f	4	22	of	of	ADP
70795715p9f	4	23	cancer	cancer	NOUN
70795715p9f	4	24	-	-	PUNCT
70795715p9f	4	25	related	relate	VERB
70795715p9f	4	26	deaths	death	NOUN
70795715p9f	4	27	must	must	AUX
70795715p9f	4	28	continue	continue	VERB
70795715p9f	4	29	.	.	PUNCT
70795715p9f	5	1	by	by	ADP
70795715p9f	5	2	and	and	CCONJ
70795715p9f	5	3	large	large	ADJ
70795715p9f	5	4	,	,	PUNCT
70795715p9f	5	5	metastasis	metastasis	NOUN
70795715p9f	5	6	,	,	PUNCT
70795715p9f	5	7	which	which	PRON
70795715p9f	5	8	is	be	AUX
70795715p9f	5	9	the	the	DET
70795715p9f	5	10	spread	spread	NOUN
70795715p9f	5	11	of	of	ADP
70795715p9f	5	12	cancer	cancer	NOUN
70795715p9f	5	13	cells	cell	NOUN
70795715p9f	5	14	from	from	ADP
70795715p9f	5	15	their	their	PRON
70795715p9f	5	16	original	original	ADJ
70795715p9f	5	17	organ	organ	NOUN
70795715p9f	5	18	site	site	NOUN
70795715p9f	5	19	,	,	PUNCT
70795715p9f	5	20	entrance	entrance	NOUN
70795715p9f	5	21	into	into	ADP
70795715p9f	5	22	circulation	circulation	NOUN
70795715p9f	5	23	,	,	PUNCT
70795715p9f	5	24	and	and	CCONJ
70795715p9f	5	25	re	re	NOUN
70795715p9f	5	26	-	-	NOUN
70795715p9f	5	27	establishment	establishment	NOUN
70795715p9f	5	28	in	in	ADP
70795715p9f	5	29	distant	distant	ADJ
70795715p9f	5	30	,	,	PUNCT
70795715p9f	5	31	secondary	secondary	ADJ
70795715p9f	5	32	organs	organ	NOUN
70795715p9f	5	33	,	,	PUNCT
70795715p9f	5	34	is	be	AUX
70795715p9f	5	35	responsible	responsible	ADJ
70795715p9f	5	36	for	for	ADP
70795715p9f	5	37	90	90	NUM
70795715p9f	5	38	%	%	NOUN
70795715p9f	5	39	of	of	ADP
70795715p9f	5	40	fatalities	fatality	NOUN
70795715p9f	5	41	caused	cause	VERB
70795715p9f	5	42	by	by	ADP
70795715p9f	5	43	cancer	cancer	NOUN
70795715p9f	5	44	.	.	PUNCT
70795715p9f	6	1	when	when	SCONJ
70795715p9f	6	2	considering	consider	VERB
70795715p9f	6	3	obstacles	obstacle	NOUN
70795715p9f	6	4	to	to	ADP
70795715p9f	6	5	cancer	cancer	NOUN
70795715p9f	6	6	cell	cell	NOUN
70795715p9f	6	7	viability	viability	NOUN
70795715p9f	6	8	,	,	PUNCT
70795715p9f	6	9	detaching	detach	VERB
70795715p9f	6	10	from	from	ADP
70795715p9f	6	11	their	their	PRON
70795715p9f	6	12	extracellular	extracellular	ADJ
70795715p9f	6	13	matrix	matrix	NOUN
70795715p9f	6	14	(	(	PUNCT
70795715p9f	6	15	ecm	ecm	NOUN
70795715p9f	6	16	)	)	PUNCT
70795715p9f	6	17	and	and	CCONJ
70795715p9f	6	18	evading	evade	VERB
70795715p9f	6	19	cell	cell	NOUN
70795715p9f	6	20	the	the	DET
70795715p9f	6	21	associated	associated	ADJ
70795715p9f	6	22	death	death	NOUN
70795715p9f	6	23	mechanisms	mechanism	NOUN
70795715p9f	6	24	are	be	AUX
70795715p9f	6	25	critical	critical	ADJ
70795715p9f	6	26	objectives	objective	NOUN
70795715p9f	6	27	cancer	cancer	NOUN
70795715p9f	6	28	cells	cell	NOUN
70795715p9f	6	29	must	must	AUX
70795715p9f	6	30	achieve	achieve	VERB
70795715p9f	6	31	to	to	ADP
70795715p9f	6	32	successfully	successfully	ADV
70795715p9f	6	33	metastasis	metastasis	NOUN
70795715p9f	6	34	.	.	PUNCT
70795715p9f	7	1	detachment	detachment	NOUN
70795715p9f	7	2	from	from	ADP
70795715p9f	7	3	the	the	DET
70795715p9f	7	4	ecm	ecm	NOUN
70795715p9f	7	5	is	be	AUX
70795715p9f	7	6	known	know	VERB
70795715p9f	7	7	to	to	PART
70795715p9f	7	8	induce	induce	VERB
70795715p9f	7	9	a	a	DET
70795715p9f	7	10	caspase	caspase	NOUN
70795715p9f	7	11	-	-	PUNCT
70795715p9f	7	12	dependent	dependent	ADJ
70795715p9f	7	13	cell	cell	NOUN
70795715p9f	7	14	death	death	NOUN
70795715p9f	7	15	program	program	NOUN
70795715p9f	7	16	,	,	PUNCT
70795715p9f	7	17	termed	term	VERB
70795715p9f	7	18	anoikis	anoiki	NOUN
70795715p9f	7	19	,	,	PUNCT
70795715p9f	7	20	that	that	SCONJ
70795715p9f	7	21	cancer	cancer	NOUN
70795715p9f	7	22	cells	cell	NOUN
70795715p9f	7	23	can	can	AUX
70795715p9f	7	24	circumvent	circumvent	VERB
70795715p9f	7	25	by	by	ADP
70795715p9f	7	26	multiple	multiple	ADJ
70795715p9f	7	27	means	mean	NOUN
70795715p9f	7	28	.	.	PUNCT
70795715p9f	8	1	nonetheless	nonetheless	ADV
70795715p9f	8	2	,	,	PUNCT
70795715p9f	8	3	overcoming	overcome	VERB
70795715p9f	8	4	caspase	caspase	NOUN
70795715p9f	8	5	-	-	PUNCT
70795715p9f	8	6	dependent	dependent	ADJ
70795715p9f	8	7	cell	cell	NOUN
70795715p9f	8	8	death	death	NOUN
70795715p9f	8	9	alone	alone	ADV
70795715p9f	8	10	is	be	AUX
70795715p9f	8	11	not	not	PART
70795715p9f	8	12	sufficient	sufficient	ADJ
70795715p9f	8	13	to	to	PART
70795715p9f	8	14	promote	promote	VERB
70795715p9f	8	15	survival	survival	NOUN
70795715p9f	8	16	during	during	ADP
70795715p9f	8	17	metastasis	metastasis	NOUN
70795715p9f	8	18	,	,	PUNCT
70795715p9f	8	19	but	but	CCONJ
70795715p9f	8	20	our	our	PRON
70795715p9f	8	21	laboratory	laboratory	NOUN
70795715p9f	8	22	's	's	PART
70795715p9f	8	23	work	work	NOUN
70795715p9f	8	24	has	have	AUX
70795715p9f	8	25	discovered	discover	VERB
70795715p9f	8	26	that	that	SCONJ
70795715p9f	8	27	cancer	cancer	NOUN
70795715p9f	8	28	cells	cell	NOUN
70795715p9f	8	29	must	must	AUX
70795715p9f	8	30	also	also	ADV
70795715p9f	8	31	address	address	VERB
70795715p9f	8	32	metabolic	metabolic	ADJ
70795715p9f	8	33	deficiencies	deficiency	NOUN
70795715p9f	8	34	that	that	PRON
70795715p9f	8	35	can	can	AUX
70795715p9f	8	36	lead	lead	VERB
70795715p9f	8	37	to	to	ADP
70795715p9f	8	38	caspase	caspase	NOUN
70795715p9f	8	39	-	-	PUNCT
70795715p9f	8	40	independent	independent	ADJ
70795715p9f	8	41	cell	cell	NOUN
70795715p9f	8	42	death	death	NOUN
70795715p9f	8	43	programs	program	NOUN
70795715p9f	8	44	.	.	PUNCT
70795715p9f	9	1	throughout	throughout	ADP
70795715p9f	9	2	my	my	PRON
70795715p9f	9	3	graduate	graduate	NOUN
70795715p9f	9	4	studies	study	NOUN
70795715p9f	9	5	,	,	PUNCT
70795715p9f	9	6	i	i	PRON
70795715p9f	9	7	have	have	AUX
70795715p9f	9	8	had	have	VERB
70795715p9f	9	9	the	the	DET
70795715p9f	9	10	honor	honor	NOUN
70795715p9f	9	11	of	of	ADP
70795715p9f	9	12	investigating	investigate	VERB
70795715p9f	9	13	two	two	NUM
70795715p9f	9	14	,	,	PUNCT
70795715p9f	9	15	separate	separate	ADJ
70795715p9f	9	16	projects	project	NOUN
70795715p9f	9	17	for	for	ADP
70795715p9f	9	18	my	my	PRON
70795715p9f	9	19	thesis	thesis	NOUN
70795715p9f	9	20	work	work	NOUN
70795715p9f	9	21	that	that	PRON
70795715p9f	9	22	entails	entail	VERB
70795715p9f	9	23	the	the	DET
70795715p9f	9	24	following	follow	VERB
70795715p9f	9	25	:	:	PUNCT
70795715p9f	9	26	1	1	X
70795715p9f	9	27	)	)	PUNCT
70795715p9f	9	28	a	a	DET
70795715p9f	9	29	survival	survival	NOUN
70795715p9f	9	30	mechanism	mechanism	NOUN
70795715p9f	9	31	to	to	PART
70795715p9f	9	32	address	address	VERB
70795715p9f	9	33	detachment	detachment	NOUN
70795715p9f	9	34	-	-	PUNCT
70795715p9f	9	35	induced	induce	VERB
70795715p9f	9	36	metabolic	metabolic	NOUN
70795715p9f	9	37	challenges	challenge	NOUN
70795715p9f	9	38	and	and	CCONJ
70795715p9f	9	39	2	2	X
70795715p9f	9	40	)	)	PUNCT
70795715p9f	9	41	a	a	DET
70795715p9f	9	42	caspase	caspase	NOUN
70795715p9f	9	43	-	-	PUNCT
70795715p9f	9	44	independent	independent	ADJ
70795715p9f	9	45	cell	cell	NOUN
70795715p9f	9	46	death	death	NOUN
70795715p9f	9	47	pathway	pathway	NOUN
70795715p9f	9	48	driven	drive	VERB
70795715p9f	9	49	by	by	ADP
70795715p9f	9	50	oxidative	oxidative	ADJ
70795715p9f	9	51	stress	stress	NOUN
70795715p9f	9	52	in	in	ADP
70795715p9f	9	53	ecm	ecm	PROPN
70795715p9f	9	54	-	-	PUNCT
70795715p9f	9	55	detached	detach	VERB
70795715p9f	9	56	cancer	cancer	NOUN
70795715p9f	9	57	cells	cell	NOUN
70795715p9f	9	58	.	.	PUNCT
70795715p9f	10	1	to	to	PART
70795715p9f	10	2	begin	begin	VERB
70795715p9f	10	3	,	,	PUNCT
70795715p9f	10	4	our	our	PRON
70795715p9f	10	5	laboratory	laboratory	NOUN
70795715p9f	10	6	's	's	PART
70795715p9f	10	7	research	research	NOUN
70795715p9f	10	8	has	have	AUX
70795715p9f	10	9	demonstrated	demonstrate	VERB
70795715p9f	10	10	that	that	SCONJ
70795715p9f	10	11	a	a	DET
70795715p9f	10	12	reduction	reduction	NOUN
70795715p9f	10	13	of	of	ADP
70795715p9f	10	14	glucose	glucose	NOUN
70795715p9f	10	15	uptake	uptake	NOUN
70795715p9f	10	16	,	,	PUNCT
70795715p9f	10	17	accumulation	accumulation	NOUN
70795715p9f	10	18	of	of	ADP
70795715p9f	10	19	reactive	reactive	ADJ
70795715p9f	10	20	oxygen	oxygen	NOUN
70795715p9f	10	21	species	specie	NOUN
70795715p9f	10	22	,	,	PUNCT
70795715p9f	10	23	and	and	CCONJ
70795715p9f	10	24	a	a	DET
70795715p9f	10	25	subsequent	subsequent	ADJ
70795715p9f	10	26	decline	decline	NOUN
70795715p9f	10	27	in	in	ADP
70795715p9f	10	28	atp	atp	PROPN
70795715p9f	10	29	production	production	NOUN
70795715p9f	10	30	are	be	AUX
70795715p9f	10	31	each	each	DET
70795715p9f	10	32	metabolic	metabolic	ADJ
70795715p9f	10	33	defects	defect	NOUN
70795715p9f	10	34	that	that	PRON
70795715p9f	10	35	occur	occur	VERB
70795715p9f	10	36	upon	upon	SCONJ
70795715p9f	10	37	ecm	ecm	NOUN
70795715p9f	10	38	-	-	PUNCT
70795715p9f	10	39	detachment	detachment	NOUN
70795715p9f	10	40	.	.	PUNCT
70795715p9f	11	1	intriguingly	intriguingly	ADV
70795715p9f	11	2	,	,	PUNCT
70795715p9f	11	3	when	when	SCONJ
70795715p9f	11	4	ecm	ecm	NOUN
70795715p9f	11	5	-	-	PUNCT
70795715p9f	11	6	detached	detach	VERB
70795715p9f	11	7	cells	cell	NOUN
70795715p9f	11	8	were	be	AUX
70795715p9f	11	9	engineered	engineer	VERB
70795715p9f	11	10	to	to	PART
70795715p9f	11	11	express	express	VERB
70795715p9f	11	12	the	the	DET
70795715p9f	11	13	erbb2	erbb2	PROPN
70795715p9f	11	14	oncogene	oncogene	NOUN
70795715p9f	11	15	,	,	PUNCT
70795715p9f	11	16	a	a	DET
70795715p9f	11	17	rectification	rectification	NOUN
70795715p9f	11	18	of	of	ADP
70795715p9f	11	19	each	each	DET
70795715p9f	11	20	metabolic	metabolic	ADJ
70795715p9f	11	21	deficiency	deficiency	NOUN
70795715p9f	11	22	was	be	AUX
70795715p9f	11	23	observed	observe	VERB
70795715p9f	11	24	.	.	PUNCT
70795715p9f	12	1	additionally	additionally	ADV
70795715p9f	12	2	,	,	PUNCT
70795715p9f	12	3	our	our	PRON
70795715p9f	12	4	previous	previous	ADJ
70795715p9f	12	5	work	work	NOUN
70795715p9f	12	6	discovered	discover	VERB
70795715p9f	12	7	that	that	SCONJ
70795715p9f	12	8	the	the	DET
70795715p9f	12	9	serine	serine	NOUN
70795715p9f	12	10	/	/	SYM
70795715p9f	12	11	threonine	threonine	NOUN
70795715p9f	12	12	serum	serum	NOUN
70795715p9f	12	13	and	and	CCONJ
70795715p9f	12	14	glucocorticoid	glucocorticoid	ADJ
70795715p9f	12	15	kinase	kinase	NOUN
70795715p9f	12	16	1	1	NUM
70795715p9f	12	17	(	(	PUNCT
70795715p9f	12	18	sgk1	sgk1	PROPN
70795715p9f	12	19	)	)	PUNCT
70795715p9f	12	20	is	be	AUX
70795715p9f	12	21	sufficient	sufficient	ADJ
70795715p9f	12	22	and	and	CCONJ
70795715p9f	12	23	required	require	VERB
70795715p9f	12	24	to	to	PART
70795715p9f	12	25	promote	promote	VERB
70795715p9f	12	26	atp	atp	PROPN
70795715p9f	12	27	production	production	NOUN
70795715p9f	12	28	in	in	ADP
70795715p9f	12	29	ecm	ecm	PROPN
70795715p9f	12	30	-	-	PUNCT
70795715p9f	12	31	detached	detach	VERB
70795715p9f	12	32	cancer	cancer	NOUN
70795715p9f	12	33	cells	cell	NOUN
70795715p9f	12	34	and	and	CCONJ
70795715p9f	12	35	to	to	PART
70795715p9f	12	36	facilitate	facilitate	VERB
70795715p9f	12	37	anchorage	anchorage	NOUN
70795715p9f	12	38	-	-	PUNCT
70795715p9f	12	39	independent	independent	ADJ
70795715p9f	12	40	growth	growth	NOUN
70795715p9f	12	41	downstream	downstream	ADV
70795715p9f	12	42	of	of	ADP
70795715p9f	12	43	the	the	DET
70795715p9f	12	44	ras	ras	PROPN
70795715p9f	12	45	oncogene	oncogene	NOUN
70795715p9f	12	46	.	.	PUNCT
70795715p9f	13	1	however	however	ADV
70795715p9f	13	2	,	,	PUNCT
70795715p9f	13	3	what	what	PRON
70795715p9f	13	4	had	have	AUX
70795715p9f	13	5	n't	not	PART
70795715p9f	13	6	been	be	AUX
70795715p9f	13	7	determined	determine	VERB
70795715p9f	13	8	yet	yet	ADV
70795715p9f	13	9	was	be	AUX
70795715p9f	13	10	the	the	DET
70795715p9f	13	11	molecular	molecular	ADJ
70795715p9f	13	12	mechanism	mechanism	NOUN
70795715p9f	13	13	that	that	PRON
70795715p9f	13	14	sgk1	sgk1	NOUN
70795715p9f	13	15	utilizes	utilize	VERB
70795715p9f	13	16	to	to	PART
70795715p9f	13	17	promote	promote	VERB
70795715p9f	13	18	these	these	DET
70795715p9f	13	19	functions	function	NOUN
70795715p9f	13	20	and	and	CCONJ
70795715p9f	13	21	if	if	SCONJ
70795715p9f	13	22	disparate	disparate	ADJ
70795715p9f	13	23	oncogenic	oncogenic	ADJ
70795715p9f	13	24	insults	insult	NOUN
70795715p9f	13	25	relied	rely	VERB
70795715p9f	13	26	on	on	ADP
70795715p9f	13	27	this	this	DET
70795715p9f	13	28	mechanism	mechanism	NOUN
70795715p9f	13	29	.	.	PUNCT
70795715p9f	14	1	therefore	therefore	ADV
70795715p9f	14	2	,	,	PUNCT
70795715p9f	14	3	utilizing	utilize	VERB
70795715p9f	14	4	four	four	NUM
70795715p9f	14	5	cancer	cancer	NOUN
70795715p9f	14	6	cell	cell	NOUN
70795715p9f	14	7	lines	line	NOUN
70795715p9f	14	8	with	with	ADP
70795715p9f	14	9	dissimilar	dissimilar	ADJ
70795715p9f	14	10	oncogenes	oncogene	NOUN
70795715p9f	14	11	,	,	PUNCT
70795715p9f	14	12	we	we	PRON
70795715p9f	14	13	performed	perform	VERB
70795715p9f	14	14	luciferase	luciferase	NOUN
70795715p9f	14	15	-	-	PUNCT
70795715p9f	14	16	based	base	VERB
70795715p9f	14	17	assays	assay	NOUN
70795715p9f	14	18	and	and	CCONJ
70795715p9f	14	19	soft	soft	ADJ
70795715p9f	14	20	agar	agar	NOUN
70795715p9f	14	21	experiments	experiment	NOUN
70795715p9f	14	22	and	and	CCONJ
70795715p9f	14	23	found	find	VERB
70795715p9f	14	24	that	that	SCONJ
70795715p9f	14	25	sgk1	sgk1	PROPN
70795715p9f	14	26	is	be	AUX
70795715p9f	14	27	not	not	PART
70795715p9f	14	28	only	only	ADV
70795715p9f	14	29	sufficient	sufficient	ADJ
70795715p9f	14	30	and	and	CCONJ
70795715p9f	14	31	required	require	VERB
70795715p9f	14	32	to	to	PART
70795715p9f	14	33	promote	promote	VERB
70795715p9f	14	34	atp	atp	PROPN
70795715p9f	14	35	generation	generation	NOUN
70795715p9f	14	36	in	in	ADP
70795715p9f	14	37	detachment	detachment	NOUN
70795715p9f	14	38	and	and	CCONJ
70795715p9f	14	39	support	support	VERB
70795715p9f	14	40	anchorage	anchorage	NOUN
70795715p9f	14	41	-	-	PUNCT
70795715p9f	14	42	independent	independent	ADJ
70795715p9f	14	43	growth	growth	NOUN
70795715p9f	14	44	,	,	PUNCT
70795715p9f	14	45	but	but	CCONJ
70795715p9f	14	46	also	also	ADV
70795715p9f	14	47	that	that	SCONJ
70795715p9f	14	48	sgk1	sgk1	NOUN
70795715p9f	14	49	preforms	preform	NOUN
70795715p9f	14	50	these	these	DET
70795715p9f	14	51	functions	function	NOUN
70795715p9f	14	52	with	with	ADP
70795715p9f	14	53	greater	great	ADJ
70795715p9f	14	54	outcomes	outcome	NOUN
70795715p9f	14	55	than	than	ADP
70795715p9f	14	56	akt	akt	PROPN
70795715p9f	14	57	in	in	ADP
70795715p9f	14	58	detachment	detachment	NOUN
70795715p9f	14	59	.	.	PUNCT
70795715p9f	15	1	furthermore	furthermore	ADV
70795715p9f	15	2	,	,	PUNCT
70795715p9f	15	3	through	through	ADP
70795715p9f	15	4	qrt	qrt	ADJ
70795715p9f	15	5	-	-	PUNCT
70795715p9f	15	6	pcr	pcr	NOUN
70795715p9f	15	7	and	and	CCONJ
70795715p9f	15	8	glucose	glucose	NOUN
70795715p9f	15	9	uptake	uptake	NOUN
70795715p9f	15	10	assays	assay	VERB
70795715p9f	15	11	,	,	PUNCT
70795715p9f	15	12	we	we	PRON
70795715p9f	15	13	found	find	VERB
70795715p9f	15	14	that	that	SCONJ
70795715p9f	15	15	in	in	ADP
70795715p9f	15	16	ecm	ecm	PROPN
70795715p9f	15	17	-	-	PUNCT
70795715p9f	15	18	detachment	detachment	ADJ
70795715p9f	15	19	sgk1	sgk1	PROPN
70795715p9f	15	20	upregulates	upregulate	VERB
70795715p9f	15	21	the	the	DET
70795715p9f	15	22	transcription	transcription	NOUN
70795715p9f	15	23	of	of	ADP
70795715p9f	15	24	the	the	DET
70795715p9f	15	25	glucose	glucose	NOUN
70795715p9f	15	26	transporter	transporter	NOUN
70795715p9f	15	27	glut1	glut1	NOUN
70795715p9f	15	28	and	and	CCONJ
70795715p9f	15	29	facilitates	facilitate	VERB
70795715p9f	15	30	increased	increase	VERB
70795715p9f	15	31	glucose	glucose	NOUN
70795715p9f	15	32	flux	flux	NOUN
70795715p9f	15	33	into	into	ADP
70795715p9f	15	34	detached	detached	ADJ
70795715p9f	15	35	cells	cell	NOUN
70795715p9f	15	36	.	.	PUNCT
70795715p9f	16	1	once	once	SCONJ
70795715p9f	16	2	glucose	glucose	NOUN
70795715p9f	16	3	in	in	ADP
70795715p9f	16	4	inside	inside	ADP
70795715p9f	16	5	the	the	DET
70795715p9f	16	6	cells	cell	NOUN
70795715p9f	16	7	,	,	PUNCT
70795715p9f	16	8	we	we	PRON
70795715p9f	16	9	surprisingly	surprisingly	ADV
70795715p9f	16	10	found	find	VERB
70795715p9f	16	11	that	that	SCONJ
70795715p9f	16	12	sgk1	sgk1	PROPN
70795715p9f	16	13	was	be	AUX
70795715p9f	16	14	not	not	PART
70795715p9f	16	15	promoting	promote	VERB
70795715p9f	16	16	atp	atp	NOUN
70795715p9f	16	17	production	production	NOUN
70795715p9f	16	18	through	through	ADP
70795715p9f	16	19	oxidative	oxidative	ADJ
70795715p9f	16	20	phosphorylation	phosphorylation	NOUN
70795715p9f	16	21	.	.	PUNCT
70795715p9f	17	1	using	use	VERB
70795715p9f	17	2	glucose	glucose	NOUN
70795715p9f	17	3	flux	flux	NOUN
70795715p9f	17	4	analysis	analysis	NOUN
70795715p9f	17	5	,	,	PUNCT
70795715p9f	17	6	we	we	PRON
70795715p9f	17	7	discovered	discover	VERB
70795715p9f	17	8	that	that	SCONJ
70795715p9f	17	9	sgk1	sgk1	PROPN
70795715p9f	17	10	promotes	promote	VERB
70795715p9f	17	11	atp	atp	NOUN
70795715p9f	17	12	production	production	NOUN
70795715p9f	17	13	and	and	CCONJ
70795715p9f	17	14	anchorage	anchorage	NOUN
70795715p9f	17	15	-	-	PUNCT
70795715p9f	17	16	independent	independent	ADJ
70795715p9f	17	17	growth	growth	NOUN
70795715p9f	17	18	via	via	ADP
70795715p9f	17	19	glucose	glucose	NOUN
70795715p9f	17	20	metabolism	metabolism	NOUN
70795715p9f	17	21	in	in	ADP
70795715p9f	17	22	both	both	CCONJ
70795715p9f	17	23	glycolytic	glycolytic	ADJ
70795715p9f	17	24	and	and	CCONJ
70795715p9f	17	25	pentose	pentose	NOUN
70795715p9f	17	26	phosphate	phosphate	NOUN
70795715p9f	17	27	pathways	pathway	NOUN
70795715p9f	17	28	(	(	PUNCT
70795715p9f	17	29	ppp	ppp	NOUN
70795715p9f	17	30	)	)	PUNCT
70795715p9f	17	31	.	.	PUNCT
70795715p9f	18	1	sgk1	sgk1	PROPN
70795715p9f	18	2	-	-	PUNCT
70795715p9f	18	3	mediated	mediate	VERB
70795715p9f	18	4	atp	atp	NOUN
70795715p9f	18	5	production	production	NOUN
70795715p9f	18	6	was	be	AUX
70795715p9f	18	7	found	find	VERB
70795715p9f	18	8	to	to	PART
70795715p9f	18	9	be	be	AUX
70795715p9f	18	10	dependent	dependent	ADJ
70795715p9f	18	11	upon	upon	SCONJ
70795715p9f	18	12	the	the	DET
70795715p9f	18	13	non	non	ADJ
70795715p9f	18	14	-	-	ADJ
70795715p9f	18	15	oxidate	oxidate	ADJ
70795715p9f	18	16	arm	arm	NOUN
70795715p9f	18	17	of	of	ADP
70795715p9f	18	18	the	the	DET
70795715p9f	18	19	ppp	ppp	NOUN
70795715p9f	18	20	due	due	ADP
70795715p9f	18	21	to	to	ADP
70795715p9f	18	22	the	the	DET
70795715p9f	18	23	flux	flux	NOUN
70795715p9f	18	24	of	of	ADP
70795715p9f	18	25	glyceraldehyde-3	glyceraldehyde-3	NOUN
70795715p9f	18	26	-	-	PUNCT
70795715p9f	18	27	phosphate	phosphate	NOUN
70795715p9f	18	28	(	(	PUNCT
70795715p9f	18	29	g3p	g3p	NOUN
70795715p9f	18	30	)	)	PUNCT
70795715p9f	18	31	into	into	ADP
70795715p9f	18	32	glycolysis	glycolysis	NOUN
70795715p9f	18	33	.	.	PUNCT
70795715p9f	19	1	taken	take	VERB
70795715p9f	19	2	together	together	ADV
70795715p9f	19	3	,	,	PUNCT
70795715p9f	19	4	our	our	PRON
70795715p9f	19	5	data	datum	NOUN
70795715p9f	19	6	published	publish	VERB
70795715p9f	19	7	in	in	ADP
70795715p9f	19	8	cell	cell	NOUN
70795715p9f	19	9	reports	report	NOUN
70795715p9f	19	10	reveals	reveal	VERB
70795715p9f	19	11	a	a	DET
70795715p9f	19	12	novel	novel	ADJ
70795715p9f	19	13	molecular	molecular	ADJ
70795715p9f	19	14	mechanism	mechanism	NOUN
70795715p9f	19	15	that	that	PRON
70795715p9f	19	16	serves	serve	VERB
70795715p9f	19	17	as	as	ADP
70795715p9f	19	18	nexus	nexus	NOUN
70795715p9f	19	19	between	between	ADP
70795715p9f	19	20	oncogenic	oncogenic	ADJ
70795715p9f	19	21	signaling	signaling	NOUN
70795715p9f	19	22	and	and	CCONJ
70795715p9f	19	23	metabolic	metabolic	NOUN
70795715p9f	19	24	reprograming	reprograme	VERB
70795715p9f	19	25	in	in	ADP
70795715p9f	19	26	ecm	ecm	PROPN
70795715p9f	19	27	-	-	PUNCT
70795715p9f	19	28	detached	detach	VERB
70795715p9f	19	29	cells	cell	NOUN
70795715p9f	19	30	for	for	ADP
70795715p9f	19	31	their	their	PRON
70795715p9f	19	32	survival	survival	NOUN
70795715p9f	19	33	in	in	ADP
70795715p9f	19	34	an	an	DET
70795715p9f	19	35	anchorage	anchorage	NOUN
70795715p9f	19	36	-	-	PUNCT
70795715p9f	19	37	independent	independent	ADJ
70795715p9f	19	38	conditions	condition	NOUN
70795715p9f	19	39	.	.	PUNCT
70795715p9f	20	1	with	with	ADP
70795715p9f	20	2	further	further	ADJ
70795715p9f	20	3	studies	study	NOUN
70795715p9f	20	4	,	,	PUNCT
70795715p9f	20	5	sgk1	sgk1	PROPN
70795715p9f	20	6	could	could	AUX
70795715p9f	20	7	possibly	possibly	ADV
70795715p9f	20	8	present	present	VERB
70795715p9f	20	9	as	as	ADP
70795715p9f	20	10	a	a	DET
70795715p9f	20	11	therapeutic	therapeutic	ADJ
70795715p9f	20	12	target	target	NOUN
70795715p9f	20	13	in	in	ADP
70795715p9f	20	14	various	various	ADJ
70795715p9f	20	15	cancer	cancer	NOUN
70795715p9f	20	16	types	type	NOUN
70795715p9f	20	17	that	that	PRON
70795715p9f	20	18	have	have	AUX
70795715p9f	20	19	detached	detach	VERB
70795715p9f	20	20	from	from	ADP
70795715p9f	20	21	their	their	PRON
70795715p9f	20	22	ecm	ecm	NOUN
70795715p9f	20	23	.	.	PUNCT
70795715p9f	21	1	lastly	lastly	ADV
70795715p9f	21	2	,	,	PUNCT
70795715p9f	21	3	within	within	ADP
70795715p9f	21	4	the	the	DET
70795715p9f	21	5	second	second	ADJ
70795715p9f	21	6	project	project	NOUN
70795715p9f	21	7	,	,	PUNCT
70795715p9f	21	8	our	our	PRON
70795715p9f	21	9	recent	recent	ADJ
70795715p9f	21	10	studies	study	NOUN
70795715p9f	21	11	using	use	VERB
70795715p9f	21	12	in	in	ADP
70795715p9f	21	13	vitro	vitro	X
70795715p9f	21	14	and	and	CCONJ
70795715p9f	21	15	in	in	ADP
70795715p9f	21	16	vivo	vivo	NOUN
70795715p9f	21	17	models	model	NOUN
70795715p9f	21	18	have	have	AUX
70795715p9f	21	19	identified	identify	VERB
70795715p9f	21	20	receptor	receptor	NOUN
70795715p9f	21	21	interacting	interact	VERB
70795715p9f	21	22	protein	protein	NOUN
70795715p9f	21	23	kinase	kinase	NOUN
70795715p9f	21	24	1	1	NUM
70795715p9f	21	25	(	(	PUNCT
70795715p9f	21	26	ripk1	ripk1	PROPN
70795715p9f	21	27	)	)	PUNCT
70795715p9f	21	28	as	as	ADP
70795715p9f	21	29	a	a	DET
70795715p9f	21	30	critical	critical	ADJ
70795715p9f	21	31	mediator	mediator	NOUN
70795715p9f	21	32	of	of	ADP
70795715p9f	21	33	ecm	ecm	PROPN
70795715p9f	21	34	-	-	PUNCT
70795715p9f	21	35	detachment	detachment	NOUN
70795715p9f	21	36	induced	induce	VERB
70795715p9f	21	37	caspase	caspase	NOUN
70795715p9f	21	38	-	-	PUNCT
70795715p9f	21	39	independent	independent	ADJ
70795715p9f	21	40	cell	cell	NOUN
70795715p9f	21	41	death	death	NOUN
70795715p9f	21	42	via	via	ADP
70795715p9f	21	43	its	its	PRON
70795715p9f	21	44	capacity	capacity	NOUN
70795715p9f	21	45	to	to	PART
70795715p9f	21	46	promote	promote	VERB
70795715p9f	21	47	mitophagy	mitophagy	NOUN
70795715p9f	21	48	,	,	PUNCT
70795715p9f	21	49	which	which	PRON
70795715p9f	21	50	is	be	AUX
70795715p9f	21	51	defined	define	VERB
70795715p9f	21	52	as	as	ADP
70795715p9f	21	53	the	the	DET
70795715p9f	21	54	degradation	degradation	NOUN
70795715p9f	21	55	of	of	ADP
70795715p9f	21	56	mitochondria	mitochondria	PROPN
70795715p9f	21	57	,	,	PUNCT
70795715p9f	21	58	and	and	CCONJ
70795715p9f	21	59	subsequent	subsequent	ADJ
70795715p9f	21	60	accumulation	accumulation	NOUN
70795715p9f	21	61	of	of	ADP
70795715p9f	21	62	mitochondrial	mitochondrial	ADJ
70795715p9f	21	63	reactive	reactive	ADJ
70795715p9f	21	64	oxygen	oxygen	NOUN
70795715p9f	21	65	species	specie	NOUN
70795715p9f	21	66	(	(	PUNCT
70795715p9f	21	67	ros	ros	X
70795715p9f	21	68	)	)	PUNCT
70795715p9f	21	69	in	in	ADP
70795715p9f	21	70	cancer	cancer	NOUN
70795715p9f	21	71	cells	cell	NOUN
70795715p9f	21	72	.	.	PUNCT
70795715p9f	22	1	thus	thus	ADV
70795715p9f	22	2	,	,	PUNCT
70795715p9f	22	3	our	our	PRON
70795715p9f	22	4	finding	finding	NOUN
70795715p9f	22	5	led	lead	VERB
70795715p9f	22	6	us	we	PRON
70795715p9f	22	7	to	to	ADP
70795715p9f	22	8	the	the	DET
70795715p9f	22	9	prominent	prominent	ADJ
70795715p9f	22	10	question	question	NOUN
70795715p9f	22	11	for	for	ADP
70795715p9f	22	12	my	my	PRON
70795715p9f	22	13	current	current	ADJ
70795715p9f	22	14	project	project	NOUN
70795715p9f	22	15	:	:	PUNCT
70795715p9f	22	16	how	how	SCONJ
70795715p9f	22	17	does	do	AUX
70795715p9f	22	18	ripk1	ripk1	PROPN
70795715p9f	22	19	-	-	PUNCT
70795715p9f	22	20	mediated	mediate	VERB
70795715p9f	22	21	mitophagy	mitophagy	NOUN
70795715p9f	22	22	lead	lead	NOUN
70795715p9f	22	23	to	to	ADP
70795715p9f	22	24	caspase	caspase	NOUN
70795715p9f	22	25	-	-	PUNCT
70795715p9f	22	26	independent	independent	ADJ
70795715p9f	22	27	cell	cell	NOUN
70795715p9f	22	28	death	death	NOUN
70795715p9f	22	29	in	in	ADP
70795715p9f	22	30	ecm	ecm	PROPN
70795715p9f	22	31	-	-	PUNCT
70795715p9f	22	32	detached	detach	VERB
70795715p9f	22	33	cancer	cancer	NOUN
70795715p9f	22	34	cells	cell	NOUN
70795715p9f	22	35	.	.	PUNCT
70795715p9f	23	1	during	during	ADP
70795715p9f	23	2	mitophagy	mitophagy	NOUN
70795715p9f	23	3	,	,	PUNCT
70795715p9f	23	4	mitochondria	mitochondria	PROPN
70795715p9f	23	5	are	be	AUX
70795715p9f	23	6	encapsulated	encapsulate	VERB
70795715p9f	23	7	into	into	ADP
70795715p9f	23	8	vesicles	vesicle	NOUN
70795715p9f	23	9	known	know	VERB
70795715p9f	23	10	as	as	ADP
70795715p9f	23	11	autophagosomes	autophagosome	NOUN
70795715p9f	23	12	,	,	PUNCT
70795715p9f	23	13	and	and	CCONJ
70795715p9f	23	14	these	these	DET
70795715p9f	23	15	vesicles	vesicle	NOUN
70795715p9f	23	16	fuse	fuse	VERB
70795715p9f	23	17	with	with	ADP
70795715p9f	23	18	lysosomes	lysosome	NOUN
70795715p9f	23	19	to	to	PART
70795715p9f	23	20	form	form	VERB
70795715p9f	23	21	autolysosomes	autolysosome	NOUN
70795715p9f	23	22	that	that	PRON
70795715p9f	23	23	execute	execute	VERB
70795715p9f	23	24	the	the	DET
70795715p9f	23	25	degradation	degradation	NOUN
70795715p9f	23	26	of	of	ADP
70795715p9f	23	27	mitochondria	mitochondria	PROPN
70795715p9f	23	28	.	.	PUNCT
70795715p9f	24	1	given	give	VERB
70795715p9f	24	2	that	that	DET
70795715p9f	24	3	mitochondria	mitochondria	NOUN
70795715p9f	24	4	contain	contain	VERB
70795715p9f	24	5	iron	iron	NOUN
70795715p9f	24	6	-	-	PUNCT
70795715p9f	24	7	rich	rich	ADJ
70795715p9f	24	8	complexes	complex	NOUN
70795715p9f	24	9	and	and	CCONJ
70795715p9f	24	10	that	that	SCONJ
70795715p9f	24	11	lysosomes	lysosome	NOUN
70795715p9f	24	12	contain	contain	VERB
70795715p9f	24	13	hydrogen	hydrogen	NOUN
70795715p9f	24	14	peroxide	peroxide	NOUN
70795715p9f	24	15	,	,	PUNCT
70795715p9f	24	16	we	we	PRON
70795715p9f	24	17	posit	posit	VERB
70795715p9f	24	18	that	that	SCONJ
70795715p9f	24	19	mitochondrial	mitochondrial	ADJ
70795715p9f	24	20	ros	ros	PROPN
70795715p9f	24	21	is	be	AUX
70795715p9f	24	22	a	a	DET
70795715p9f	24	23	result	result	NOUN
70795715p9f	24	24	of	of	ADP
70795715p9f	24	25	the	the	DET
70795715p9f	24	26	fenton	fenton	NOUN
70795715p9f	24	27	reaction	reaction	NOUN
70795715p9f	24	28	(	(	PUNCT
70795715p9f	24	29	fe2++h2o2	fe2++h2o2	NOUN
70795715p9f	24	30	=	=	SYM
70795715p9f	24	31	fe3	fe3	PROPN
70795715p9f	24	32	+	+	PROPN
70795715p9f	24	33	+	+	NUM
70795715p9f	24	34	h2o	h2o	NOUN
70795715p9f	25	1	+	+	NUM
70795715p9f	25	2	oh	oh	INTJ
70795715p9f	25	3	)	)	PUNCT
70795715p9f	25	4	occurring	occur	VERB
70795715p9f	25	5	in	in	ADP
70795715p9f	25	6	autolysosomes	autolysosome	NOUN
70795715p9f	25	7	during	during	ADP
70795715p9f	25	8	mitophagy	mitophagy	NOUN
70795715p9f	25	9	in	in	ADP
70795715p9f	25	10	ecm	ecm	NOUN
70795715p9f	25	11	-	-	PUNCT
70795715p9f	25	12	detachment	detachment	NOUN
70795715p9f	25	13	.	.	PUNCT
70795715p9f	26	1	additionally	additionally	ADV
70795715p9f	26	2	,	,	PUNCT
70795715p9f	26	3	because	because	SCONJ
70795715p9f	26	4	of	of	ADP
70795715p9f	26	5	its	its	PRON
70795715p9f	26	6	accumulation	accumulation	NOUN
70795715p9f	26	7	,	,	PUNCT
70795715p9f	26	8	mitochondrial	mitochondrial	ADJ
70795715p9f	26	9	ros	ros	PROPN
70795715p9f	26	10	can	can	AUX
70795715p9f	26	11	lead	lead	VERB
70795715p9f	26	12	to	to	ADP
70795715p9f	26	13	the	the	DET
70795715p9f	26	14	loss	loss	NOUN
70795715p9f	26	15	of	of	ADP
70795715p9f	26	16	lysosomal	lysosomal	NOUN
70795715p9f	26	17	membrane	membrane	NOUN
70795715p9f	26	18	integrity	integrity	NOUN
70795715p9f	26	19	,	,	PUNCT
70795715p9f	26	20	a	a	DET
70795715p9f	26	21	process	process	NOUN
70795715p9f	26	22	known	know	VERB
70795715p9f	26	23	as	as	ADP
70795715p9f	26	24	lysosomal	lysosomal	NOUN
70795715p9f	26	25	membrane	membrane	NOUN
70795715p9f	26	26	permeabilization	permeabilization	NOUN
70795715p9f	26	27	(	(	PUNCT
70795715p9f	26	28	lmp	lmp	PROPN
70795715p9f	26	29	)	)	PUNCT
70795715p9f	26	30	,	,	PUNCT
70795715p9f	26	31	and	and	CCONJ
70795715p9f	26	32	cause	cause	VERB
70795715p9f	26	33	the	the	DET
70795715p9f	26	34	release	release	NOUN
70795715p9f	26	35	of	of	ADP
70795715p9f	26	36	active	active	ADJ
70795715p9f	26	37	cathepsins	cathepsin	NOUN
70795715p9f	26	38	that	that	PRON
70795715p9f	26	39	have	have	AUX
70795715p9f	26	40	been	be	AUX
70795715p9f	26	41	observed	observe	VERB
70795715p9f	26	42	to	to	PART
70795715p9f	26	43	execute	execute	VERB
70795715p9f	26	44	caspase	caspase	NOUN
70795715p9f	26	45	-	-	PUNCT
70795715p9f	26	46	independent	independent	ADJ
70795715p9f	26	47	cell	cell	NOUN
70795715p9f	26	48	death	death	NOUN
70795715p9f	26	49	once	once	ADV
70795715p9f	26	50	in	in	ADP
70795715p9f	26	51	the	the	DET
70795715p9f	26	52	cytosol	cytosol	NOUN
70795715p9f	26	53	.	.	PUNCT
70795715p9f	27	1	to	to	ADP
70795715p9f	27	2	date	date	NOUN
70795715p9f	27	3	,	,	PUNCT
70795715p9f	27	4	using	use	VERB
70795715p9f	27	5	a	a	DET
70795715p9f	27	6	combination	combination	NOUN
70795715p9f	27	7	of	of	ADP
70795715p9f	27	8	subcellular	subcellular	ADJ
70795715p9f	27	9	fractionation	fractionation	NOUN
70795715p9f	27	10	,	,	PUNCT
70795715p9f	27	11	immunoblotting	immunoblotting	ADJ
70795715p9f	27	12	,	,	PUNCT
70795715p9f	27	13	immunofluorescence	immunofluorescence	NOUN
70795715p9f	27	14	,	,	PUNCT
70795715p9f	27	15	and	and	CCONJ
70795715p9f	27	16	enzymatic	enzymatic	ADJ
70795715p9f	27	17	activity	activity	NOUN
70795715p9f	27	18	assays	assay	NOUN
70795715p9f	27	19	,	,	PUNCT
70795715p9f	27	20	we	we	PRON
70795715p9f	27	21	have	have	AUX
70795715p9f	27	22	discovered	discover	VERB
70795715p9f	27	23	that	that	SCONJ
70795715p9f	27	24	ecm	ecm	NOUN
70795715p9f	27	25	-	-	PUNCT
70795715p9f	27	26	detachment	detachment	NOUN
70795715p9f	27	27	induces	induce	VERB
70795715p9f	27	28	lmp	lmp	NOUN
70795715p9f	27	29	and	and	CCONJ
70795715p9f	27	30	that	that	SCONJ
70795715p9f	27	31	this	this	DET
70795715p9f	27	32	lmp	lmp	NOUN
70795715p9f	27	33	is	be	AUX
70795715p9f	27	34	dependent	dependent	ADJ
70795715p9f	27	35	upon	upon	SCONJ
70795715p9f	27	36	ripk1	ripk1	PROPN
70795715p9f	27	37	-	-	PUNCT
70795715p9f	27	38	mediated	mediate	VERB
70795715p9f	27	39	mitophagy	mitophagy	NOUN
70795715p9f	27	40	.	.	PUNCT
70795715p9f	28	1	likewise	likewise	ADV
70795715p9f	28	2	,	,	PUNCT
70795715p9f	28	3	during	during	ADP
70795715p9f	28	4	detachment	detachment	NOUN
70795715p9f	28	5	,	,	PUNCT
70795715p9f	28	6	not	not	PART
70795715p9f	28	7	only	only	ADV
70795715p9f	28	8	have	have	AUX
70795715p9f	28	9	we	we	PRON
70795715p9f	28	10	observed	observe	VERB
70795715p9f	28	11	the	the	DET
70795715p9f	28	12	release	release	NOUN
70795715p9f	28	13	of	of	ADP
70795715p9f	28	14	cathepsin	cathepsin	PROPN
70795715p9f	28	15	b	b	PROPN
70795715p9f	28	16	into	into	ADP
70795715p9f	28	17	the	the	DET
70795715p9f	28	18	cytosol	cytosol	NOUN
70795715p9f	28	19	(	(	PUNCT
70795715p9f	28	20	a	a	DET
70795715p9f	28	21	marker	marker	NOUN
70795715p9f	28	22	for	for	ADP
70795715p9f	28	23	lmp	lmp	PROPN
70795715p9f	28	24	)	)	PUNCT
70795715p9f	28	25	,	,	PUNCT
70795715p9f	28	26	but	but	CCONJ
70795715p9f	28	27	our	our	PRON
70795715p9f	28	28	data	datum	NOUN
70795715p9f	28	29	also	also	ADV
70795715p9f	28	30	show	show	VERB
70795715p9f	28	31	that	that	SCONJ
70795715p9f	28	32	detachment	detachment	NOUN
70795715p9f	28	33	regulates	regulate	VERB
70795715p9f	28	34	the	the	DET
70795715p9f	28	35	activity	activity	NOUN
70795715p9f	28	36	of	of	ADP
70795715p9f	28	37	cathepsin	cathepsin	PROPN
70795715p9f	28	38	b	b	PROPN
70795715p9f	28	39	in	in	ADP
70795715p9f	28	40	a	a	DET
70795715p9f	28	41	ripk1	ripk1	ADJ
70795715p9f	28	42	and	and	CCONJ
70795715p9f	28	43	mitochondrial	mitochondrial	ADJ
70795715p9f	28	44	ros	ros	NOUN
70795715p9f	28	45	-	-	PUNCT
70795715p9f	28	46	dependent	dependent	ADJ
70795715p9f	28	47	fashion	fashion	NOUN
70795715p9f	28	48	.	.	PUNCT
70795715p9f	29	1	with	with	ADP
70795715p9f	29	2	this	this	DET
70795715p9f	29	3	discovery	discovery	NOUN
70795715p9f	29	4	in	in	ADP
70795715p9f	29	5	addition	addition	NOUN
70795715p9f	29	6	to	to	ADP
70795715p9f	29	7	previous	previous	ADJ
70795715p9f	29	8	studies	study	NOUN
70795715p9f	29	9	depicting	depict	VERB
70795715p9f	29	10	its	its	PRON
70795715p9f	29	11	role	role	NOUN
70795715p9f	29	12	in	in	ADP
70795715p9f	29	13	caspase	caspase	NOUN
70795715p9f	29	14	-	-	PUNCT
70795715p9f	29	15	independent	independent	ADJ
70795715p9f	29	16	cell	cell	NOUN
70795715p9f	29	17	death	death	NOUN
70795715p9f	29	18	,	,	PUNCT
70795715p9f	29	19	it	it	PRON
70795715p9f	29	20	is	be	AUX
70795715p9f	29	21	possible	possible	ADJ
70795715p9f	29	22	that	that	SCONJ
70795715p9f	29	23	cathepsin	cathepsin	PROPN
70795715p9f	29	24	b	b	PROPN
70795715p9f	29	25	is	be	AUX
70795715p9f	29	26	playing	play	VERB
70795715p9f	29	27	a	a	DET
70795715p9f	29	28	prominent	prominent	ADJ
70795715p9f	29	29	role	role	NOUN
70795715p9f	29	30	in	in	ADP
70795715p9f	29	31	facilitating	facilitate	VERB
70795715p9f	29	32	cell	cell	NOUN
70795715p9f	29	33	death	death	NOUN
70795715p9f	29	34	that	that	PRON
70795715p9f	29	35	occurs	occur	VERB
70795715p9f	29	36	as	as	ADP
70795715p9f	29	37	a	a	DET
70795715p9f	29	38	result	result	NOUN
70795715p9f	29	39	of	of	ADP
70795715p9f	29	40	ripk1	ripk1	PROPN
70795715p9f	29	41	-	-	PUNCT
70795715p9f	29	42	mediated	mediate	VERB
70795715p9f	29	43	mitophagy	mitophagy	NOUN
70795715p9f	29	44	.	.	PUNCT
70795715p9f	30	1	therefore	therefore	ADV
70795715p9f	30	2	,	,	PUNCT
70795715p9f	30	3	our	our	PRON
70795715p9f	30	4	current	current	ADJ
70795715p9f	30	5	focus	focus	NOUN
70795715p9f	30	6	entails	entail	VERB
70795715p9f	30	7	investigating	investigate	VERB
70795715p9f	30	8	the	the	DET
70795715p9f	30	9	requirement	requirement	NOUN
70795715p9f	30	10	and	and	CCONJ
70795715p9f	30	11	mechanism	mechanism	NOUN
70795715p9f	30	12	of	of	ADP
70795715p9f	30	13	cathepsin	cathepsin	PROPN
70795715p9f	30	14	b	b	PROPN
70795715p9f	30	15	to	to	PART
70795715p9f	30	16	promote	promote	VERB
70795715p9f	30	17	caspase	caspase	NOUN
70795715p9f	30	18	-	-	PUNCT
70795715p9f	30	19	independent	independent	ADJ
70795715p9f	30	20	cell	cell	NOUN
70795715p9f	30	21	death	death	NOUN
70795715p9f	30	22	downstream	downstream	ADV
70795715p9f	30	23	of	of	ADP
70795715p9f	30	24	ripk1	ripk1	ADJ
70795715p9f	30	25	activity	activity	NOUN
70795715p9f	30	26	in	in	ADP
70795715p9f	30	27	ecm	ecm	NOUN
70795715p9f	30	28	-	-	PUNCT
70795715p9f	30	29	detachment	detachment	NOUN
70795715p9f	30	30	.	.	PUNCT
70795715p9f	31	1	in	in	ADP
70795715p9f	31	2	brief	brief	ADJ
70795715p9f	31	3	,	,	PUNCT
70795715p9f	31	4	elucidating	elucidate	VERB
70795715p9f	31	5	a	a	DET
70795715p9f	31	6	novel	novel	ADJ
70795715p9f	31	7	cell	cell	NOUN
70795715p9f	31	8	death	death	NOUN
70795715p9f	31	9	pathway	pathway	NOUN
70795715p9f	31	10	that	that	PRON
70795715p9f	31	11	could	could	AUX
70795715p9f	31	12	potentially	potentially	ADV
70795715p9f	31	13	reveal	reveal	VERB
70795715p9f	31	14	therapeutic	therapeutic	ADJ
70795715p9f	31	15	targets	target	NOUN
70795715p9f	31	16	for	for	ADP
70795715p9f	31	17	treatments	treatment	NOUN
70795715p9f	31	18	,	,	PUNCT
70795715p9f	31	19	particularly	particularly	ADV
70795715p9f	31	20	in	in	ADP
70795715p9f	31	21	cancers	cancer	NOUN
70795715p9f	31	22	that	that	PRON
70795715p9f	31	23	have	have	AUX
70795715p9f	31	24	acquired	acquire	VERB
70795715p9f	31	25	resistance	resistance	NOUN
70795715p9f	31	26	to	to	ADP
70795715p9f	31	27	caspase	caspase	NOUN
70795715p9f	31	28	-	-	PUNCT
70795715p9f	31	29	dependent	dependent	ADJ
70795715p9f	31	30	cell	cell	NOUN
70795715p9f	31	31	death	death	NOUN
70795715p9f	31	32	,	,	PUNCT
70795715p9f	31	33	truly	truly	ADV
70795715p9f	31	34	highlights	highlight	VERB
70795715p9f	31	35	the	the	DET
70795715p9f	31	36	significance	significance	NOUN
70795715p9f	31	37	of	of	ADP
70795715p9f	31	38	this	this	DET
70795715p9f	31	39	project	project	NOUN
70795715p9f	31	40	.	.	PUNCT