id	sid	tid	token	lemma	pos
70795715p1p	1	1	this	this	DET
70795715p1p	1	2	dissertation	dissertation	NOUN
70795715p1p	1	3	focuses	focus	VERB
70795715p1p	1	4	on	on	ADP
70795715p1p	1	5	the	the	DET
70795715p1p	1	6	design	design	NOUN
70795715p1p	1	7	,	,	PUNCT
70795715p1p	1	8	synthesis	synthesis	NOUN
70795715p1p	1	9	,	,	PUNCT
70795715p1p	1	10	characterization	characterization	NOUN
70795715p1p	1	11	,	,	PUNCT
70795715p1p	1	12	and	and	CCONJ
70795715p1p	1	13	mechanistic	mechanistic	ADJ
70795715p1p	1	14	evaluation	evaluation	NOUN
70795715p1p	1	15	of	of	ADP
70795715p1p	1	16	selective	selective	ADJ
70795715p1p	1	17	targeted	target	VERB
70795715p1p	1	18	nanomedicines	nanomedicine	NOUN
70795715p1p	1	19	with	with	ADP
70795715p1p	1	20	endosomolytic	endosomolytic	ADJ
70795715p1p	1	21	properties	property	NOUN
70795715p1p	1	22	for	for	ADP
70795715p1p	1	23	efficient	efficient	ADJ
70795715p1p	1	24	intracellular	intracellular	ADJ
70795715p1p	1	25	delivery	delivery	NOUN
70795715p1p	1	26	of	of	ADP
70795715p1p	1	27	chemotherapeutic	chemotherapeutic	ADJ
70795715p1p	1	28	agents	agent	NOUN
70795715p1p	1	29	.	.	PUNCT
70795715p1p	2	1	targeted	target	VERB
70795715p1p	2	2	nanomedicine	nanomedicine	NOUN
70795715p1p	2	3	result	result	NOUN
70795715p1p	2	4	from	from	ADP
70795715p1p	2	5	modification	modification	NOUN
70795715p1p	2	6	of	of	ADP
70795715p1p	2	7	nanoparticles	nanoparticle	NOUN
70795715p1p	2	8	(	(	PUNCT
70795715p1p	2	9	e.g.	e.g.	ADV
70795715p1p	2	10	,	,	PUNCT
70795715p1p	2	11	liposomes	liposome	NOUN
70795715p1p	2	12	)	)	PUNCT
70795715p1p	2	13	with	with	ADP
70795715p1p	2	14	ligands	ligand	NOUN
70795715p1p	2	15	capable	capable	ADJ
70795715p1p	2	16	of	of	ADP
70795715p1p	2	17	binding	bind	VERB
70795715p1p	2	18	to	to	ADP
70795715p1p	2	19	cell	cell	NOUN
70795715p1p	2	20	-	-	PUNCT
70795715p1p	2	21	surface	surface	NOUN
70795715p1p	2	22	receptors	receptor	NOUN
70795715p1p	2	23	with	with	ADP
70795715p1p	2	24	high	high	ADJ
70795715p1p	2	25	specificity	specificity	NOUN
70795715p1p	2	26	and	and	CCONJ
70795715p1p	2	27	the	the	DET
70795715p1p	2	28	ability	ability	NOUN
70795715p1p	2	29	trigger	trigger	VERB
70795715p1p	2	30	cellular	cellular	ADJ
70795715p1p	2	31	uptake	uptake	NOUN
70795715p1p	2	32	or	or	CCONJ
70795715p1p	2	33	internalization	internalization	NOUN
70795715p1p	2	34	.	.	PUNCT
70795715p1p	3	1	targeted	target	VERB
70795715p1p	3	2	nanoparticles	nanoparticle	NOUN
70795715p1p	3	3	have	have	AUX
70795715p1p	3	4	been	be	AUX
70795715p1p	3	5	shown	show	VERB
70795715p1p	3	6	to	to	PART
70795715p1p	3	7	provide	provide	VERB
70795715p1p	3	8	significant	significant	ADJ
70795715p1p	3	9	enhancements	enhancement	NOUN
70795715p1p	3	10	in	in	ADP
70795715p1p	3	11	receptor	receptor	NOUN
70795715p1p	3	12	-	-	PUNCT
70795715p1p	3	13	mediated	mediate	VERB
70795715p1p	3	14	internalization	internalization	NOUN
70795715p1p	3	15	with	with	ADP
70795715p1p	3	16	great	great	ADJ
70795715p1p	3	17	promise	promise	NOUN
70795715p1p	3	18	for	for	ADP
70795715p1p	3	19	personalized	personalized	ADJ
70795715p1p	3	20	medicine	medicine	NOUN
70795715p1p	3	21	but	but	CCONJ
70795715p1p	3	22	have	have	VERB
70795715p1p	3	23	yet	yet	ADV
70795715p1p	3	24	to	to	PART
70795715p1p	3	25	reach	reach	VERB
70795715p1p	3	26	the	the	DET
70795715p1p	3	27	clinic.three	clinic.three	NOUN
70795715p1p	3	28	separate	separate	ADJ
70795715p1p	3	29	components	component	NOUN
70795715p1p	3	30	of	of	ADP
70795715p1p	3	31	rational	rational	ADJ
70795715p1p	3	32	nanomedicine	nanomedicine	NOUN
70795715p1p	3	33	design	design	NOUN
70795715p1p	3	34	are	be	AUX
70795715p1p	3	35	explored	explore	VERB
70795715p1p	3	36	throughout	throughout	ADP
70795715p1p	3	37	this	this	DET
70795715p1p	3	38	dissertation	dissertation	NOUN
70795715p1p	3	39	.	.	PUNCT
70795715p1p	4	1	in	in	ADP
70795715p1p	4	2	chapter	chapter	NOUN
70795715p1p	4	3	one	one	NUM
70795715p1p	4	4	,	,	PUNCT
70795715p1p	4	5	the	the	DET
70795715p1p	4	6	rational	rational	ADJ
70795715p1p	4	7	design	design	NOUN
70795715p1p	4	8	of	of	ADP
70795715p1p	4	9	multivalent	multivalent	ADJ
70795715p1p	4	10	systems	system	NOUN
70795715p1p	4	11	is	be	AUX
70795715p1p	4	12	explained	explain	VERB
70795715p1p	4	13	,	,	PUNCT
70795715p1p	4	14	suggesting	suggest	VERB
70795715p1p	4	15	a	a	DET
70795715p1p	4	16	paradigm	paradigm	NOUN
70795715p1p	4	17	shift	shift	NOUN
70795715p1p	4	18	in	in	ADP
70795715p1p	4	19	the	the	DET
70795715p1p	4	20	optimization	optimization	NOUN
70795715p1p	4	21	parameters	parameter	NOUN
70795715p1p	4	22	for	for	ADP
70795715p1p	4	23	targeted	targeted	ADJ
70795715p1p	4	24	nanomedicines	nanomedicine	NOUN
70795715p1p	4	25	:	:	PUNCT
70795715p1p	4	26	prioritize	prioritize	VERB
70795715p1p	4	27	selectivity	selectivity	NOUN
70795715p1p	4	28	,	,	PUNCT
70795715p1p	4	29	not	not	PART
70795715p1p	4	30	avidity	avidity	NOUN
70795715p1p	4	31	.	.	PUNCT
70795715p1p	5	1	next	next	ADV
70795715p1p	5	2	,	,	PUNCT
70795715p1p	5	3	chapters	chapter	NOUN
70795715p1p	5	4	two	two	NUM
70795715p1p	5	5	and	and	CCONJ
70795715p1p	5	6	three	three	NUM
70795715p1p	5	7	focus	focus	NOUN
70795715p1p	5	8	on	on	ADP
70795715p1p	5	9	how	how	SCONJ
70795715p1p	5	10	targeted	target	VERB
70795715p1p	5	11	nanomedicines	nanomedicine	NOUN
70795715p1p	5	12	can	can	AUX
70795715p1p	5	13	be	be	AUX
70795715p1p	5	14	rationally	rationally	ADV
70795715p1p	5	15	designed	design	VERB
70795715p1p	5	16	for	for	ADP
70795715p1p	5	17	tackling	tackle	VERB
70795715p1p	5	18	one	one	NUM
70795715p1p	5	19	of	of	ADP
70795715p1p	5	20	the	the	DET
70795715p1p	5	21	major	major	ADJ
70795715p1p	5	22	bottlenecks	bottleneck	NOUN
70795715p1p	5	23	in	in	ADP
70795715p1p	5	24	nanoparticle	nanoparticle	NOUN
70795715p1p	5	25	-	-	PUNCT
70795715p1p	5	26	based	base	VERB
70795715p1p	5	27	drug	drug	NOUN
70795715p1p	5	28	delivery	delivery	NOUN
70795715p1p	5	29	:	:	PUNCT
70795715p1p	5	30	endosomal	endosomal	ADJ
70795715p1p	5	31	escape	escape	NOUN
70795715p1p	5	32	.	.	PUNCT
70795715p1p	6	1	in	in	ADP
70795715p1p	6	2	short	short	ADJ
70795715p1p	6	3	,	,	PUNCT
70795715p1p	6	4	following	follow	VERB
70795715p1p	6	5	internalization	internalization	NOUN
70795715p1p	6	6	,	,	PUNCT
70795715p1p	6	7	nanoparticles	nanoparticle	NOUN
70795715p1p	6	8	are	be	AUX
70795715p1p	6	9	shuttled	shuttle	VERB
70795715p1p	6	10	through	through	ADP
70795715p1p	6	11	endosomal	endosomal	ADJ
70795715p1p	6	12	vesicles	vesicle	NOUN
70795715p1p	6	13	leading	lead	VERB
70795715p1p	6	14	to	to	ADP
70795715p1p	6	15	exocytosis	exocytosis	NOUN
70795715p1p	6	16	/	/	SYM
70795715p1p	6	17	recycling	recycling	NOUN
70795715p1p	6	18	or	or	CCONJ
70795715p1p	6	19	lysosomal	lysosomal	NOUN
70795715p1p	6	20	degradation	degradation	NOUN
70795715p1p	6	21	,	,	PUNCT
70795715p1p	6	22	rarely	rarely	ADV
70795715p1p	6	23	reaching	reach	VERB
70795715p1p	6	24	the	the	DET
70795715p1p	6	25	cytosolic	cytosolic	NOUN
70795715p1p	6	26	compartment	compartment	NOUN
70795715p1p	6	27	.	.	PUNCT
70795715p1p	7	1	using	use	VERB
70795715p1p	7	2	a	a	DET
70795715p1p	7	3	modular	modular	ADJ
70795715p1p	7	4	liposomal	liposomal	ADJ
70795715p1p	7	5	nanoparticle	nanoparticle	NOUN
70795715p1p	7	6	system	system	NOUN
70795715p1p	7	7	,	,	PUNCT
70795715p1p	7	8	we	we	PRON
70795715p1p	7	9	have	have	AUX
70795715p1p	7	10	studied	study	VERB
70795715p1p	7	11	the	the	DET
70795715p1p	7	12	implications	implication	NOUN
70795715p1p	7	13	of	of	ADP
70795715p1p	7	14	endosomal	endosomal	ADJ
70795715p1p	7	15	escape	escape	NOUN
70795715p1p	7	16	moieties	moiety	NOUN
70795715p1p	7	17	in	in	ADP
70795715p1p	7	18	targeted	target	VERB
70795715p1p	7	19	drug	drug	NOUN
70795715p1p	7	20	delivery	delivery	NOUN
70795715p1p	7	21	and	and	CCONJ
70795715p1p	7	22	determined	determine	VERB
70795715p1p	7	23	optimizable	optimizable	ADJ
70795715p1p	7	24	parameters	parameter	NOUN
70795715p1p	7	25	for	for	ADP
70795715p1p	7	26	optimization	optimization	NOUN
70795715p1p	7	27	,	,	PUNCT
70795715p1p	7	28	improving	improve	VERB
70795715p1p	7	29	targeted	target	VERB
70795715p1p	7	30	nanoparticle	nanoparticle	NOUN
70795715p1p	7	31	internalization	internalization	NOUN
70795715p1p	7	32	&	&	CCONJ
70795715p1p	7	33	gt;10	gt;10	SPACE
70795715p1p	7	34	-	-	ADJ
70795715p1p	7	35	fold	fold	ADJ
70795715p1p	7	36	and	and	CCONJ
70795715p1p	7	37	nanomedicine	nanomedicine	ADJ
70795715p1p	7	38	potency	potency	NOUN
70795715p1p	7	39	by	by	ADP
70795715p1p	7	40	~3	~3	ADJ
70795715p1p	7	41	-	-	ADJ
70795715p1p	7	42	fold	fold	ADJ
70795715p1p	7	43	.	.	PUNCT
70795715p1p	8	1	importantly	importantly	ADV
70795715p1p	8	2	mechanistic	mechanistic	ADJ
70795715p1p	8	3	differences	difference	NOUN
70795715p1p	8	4	between	between	ADP
70795715p1p	8	5	the	the	DET
70795715p1p	8	6	endosomal	endosomal	ADJ
70795715p1p	8	7	escape	escape	NOUN
70795715p1p	8	8	of	of	ADP
70795715p1p	8	9	targeted	targeted	ADJ
70795715p1p	8	10	and	and	CCONJ
70795715p1p	8	11	non	non	ADJ
70795715p1p	8	12	-	-	ADJ
70795715p1p	8	13	targeted	targeted	ADJ
70795715p1p	8	14	nanomedicines	nanomedicine	NOUN
70795715p1p	8	15	were	be	AUX
70795715p1p	8	16	evaluated	evaluate	VERB
70795715p1p	8	17	,	,	PUNCT
70795715p1p	8	18	providing	provide	VERB
70795715p1p	8	19	further	further	ADJ
70795715p1p	8	20	insight	insight	NOUN
70795715p1p	8	21	into	into	ADP
70795715p1p	8	22	endosomal	endosomal	ADJ
70795715p1p	8	23	escape	escape	NOUN
70795715p1p	8	24	for	for	ADP
70795715p1p	8	25	basic	basic	ADJ
70795715p1p	8	26	and	and	CCONJ
70795715p1p	8	27	applied	applied	ADJ
70795715p1p	8	28	sciences	science	NOUN
70795715p1p	8	29	.	.	PUNCT
70795715p1p	9	1	finally	finally	ADV
70795715p1p	9	2	,	,	PUNCT
70795715p1p	9	3	lessons	lesson	NOUN
70795715p1p	9	4	learned	learn	VERB
70795715p1p	9	5	from	from	ADP
70795715p1p	9	6	targeting	target	VERB
70795715p1p	9	7	and	and	CCONJ
70795715p1p	9	8	endosomolytic	endosomolytic	ADJ
70795715p1p	9	9	design	design	NOUN
70795715p1p	9	10	are	be	AUX
70795715p1p	9	11	combined	combine	VERB
70795715p1p	9	12	with	with	ADP
70795715p1p	9	13	the	the	DET
70795715p1p	9	14	design	design	NOUN
70795715p1p	9	15	of	of	ADP
70795715p1p	9	16	prodrugs	prodrug	NOUN
70795715p1p	9	17	that	that	PRON
70795715p1p	9	18	improve	improve	VERB
70795715p1p	9	19	selectivity	selectivity	NOUN
70795715p1p	9	20	of	of	ADP
70795715p1p	9	21	nanomedicines	nanomedicine	NOUN
70795715p1p	9	22	by	by	ADP
70795715p1p	9	23	optimizing	optimize	VERB
70795715p1p	9	24	for	for	ADP
70795715p1p	9	25	intracellular	intracellular	ADJ
70795715p1p	9	26	release	release	NOUN
70795715p1p	9	27	rather	rather	ADV
70795715p1p	9	28	than	than	ADP
70795715p1p	9	29	sustained	sustain	VERB
70795715p1p	9	30	released.altogether	released.altogether	PROPN
70795715p1p	9	31	,	,	PUNCT
70795715p1p	9	32	this	this	DET
70795715p1p	9	33	work	work	NOUN
70795715p1p	9	34	provides	provide	VERB
70795715p1p	9	35	guideline	guideline	NOUN
70795715p1p	9	36	for	for	ADP
70795715p1p	9	37	the	the	DET
70795715p1p	9	38	rational	rational	ADJ
70795715p1p	9	39	design	design	NOUN
70795715p1p	9	40	of	of	ADP
70795715p1p	9	41	targeted	target	VERB
70795715p1p	9	42	nanomedicines	nanomedicine	NOUN
70795715p1p	9	43	and	and	CCONJ
70795715p1p	9	44	highlights	highlight	VERB
70795715p1p	9	45	the	the	DET
70795715p1p	9	46	value	value	NOUN
70795715p1p	9	47	of	of	ADP
70795715p1p	9	48	systematic	systematic	ADJ
70795715p1p	9	49	analysis	analysis	NOUN
70795715p1p	9	50	for	for	ADP
70795715p1p	9	51	the	the	DET
70795715p1p	9	52	basic	basic	ADJ
70795715p1p	9	53	understanding	understanding	NOUN
70795715p1p	9	54	of	of	ADP
70795715p1p	9	55	biological	biological	ADJ
70795715p1p	9	56	problems	problem	NOUN
70795715p1p	9	57	,	,	PUNCT
70795715p1p	9	58	followed	follow	VERB
70795715p1p	9	59	by	by	ADP
70795715p1p	9	60	application	application	NOUN
70795715p1p	9	61	of	of	ADP
70795715p1p	9	62	this	this	DET
70795715p1p	9	63	knowledge	knowledge	NOUN
70795715p1p	9	64	for	for	ADP
70795715p1p	9	65	engineering	engineering	NOUN
70795715p1p	9	66	solutions	solution	NOUN
70795715p1p	9	67	that	that	PRON
70795715p1p	9	68	improve	improve	VERB
70795715p1p	9	69	patient	patient	ADJ
70795715p1p	9	70	outcome	outcome	NOUN
70795715p1p	9	71	.	.	PUNCT