id sid tid token lemma pos 6m311n81j7k 1 1 the the DET 6m311n81j7k 1 2 conformation conformation NOUN 6m311n81j7k 1 3 of of ADP 6m311n81j7k 1 4 a a DET 6m311n81j7k 1 5 small small ADJ 6m311n81j7k 1 6 molecule molecule NOUN 6m311n81j7k 1 7 is be AUX 6m311n81j7k 1 8 crucial crucial ADJ 6m311n81j7k 1 9 to to ADP 6m311n81j7k 1 10 its its PRON 6m311n81j7k 1 11 biological biological ADJ 6m311n81j7k 1 12 activity activity NOUN 6m311n81j7k 1 13 , , PUNCT 6m311n81j7k 1 14 as as SCONJ 6m311n81j7k 1 15 ideal ideal ADJ 6m311n81j7k 1 16 binding binding NOUN 6m311n81j7k 1 17 requires require VERB 6m311n81j7k 1 18 both both DET 6m311n81j7k 1 19 ligand ligand NOUN 6m311n81j7k 1 20 and and CCONJ 6m311n81j7k 1 21 protein protein NOUN 6m311n81j7k 1 22 to to PART 6m311n81j7k 1 23 spatially spatially ADV 6m311n81j7k 1 24 complement complement VERB 6m311n81j7k 1 25 one one NOUN 6m311n81j7k 1 26 another another DET 6m311n81j7k 1 27 . . PUNCT 6m311n81j7k 2 1 this this PRON 6m311n81j7k 2 2 is be AUX 6m311n81j7k 2 3 particularly particularly ADV 6m311n81j7k 2 4 important important ADJ 6m311n81j7k 2 5 when when SCONJ 6m311n81j7k 2 6 considering consider VERB 6m311n81j7k 2 7 compounds compound NOUN 6m311n81j7k 2 8 such such ADJ 6m311n81j7k 2 9 as as ADP 6m311n81j7k 2 10 the the DET 6m311n81j7k 2 11 polyketide polyketide NOUN 6m311n81j7k 2 12 class class NOUN 6m311n81j7k 2 13 of of ADP 6m311n81j7k 2 14 bioactive bioactive ADJ 6m311n81j7k 2 15 natural natural ADJ 6m311n81j7k 2 16 products product NOUN 6m311n81j7k 2 17 , , PUNCT 6m311n81j7k 2 18 in in ADP 6m311n81j7k 2 19 which which PRON 6m311n81j7k 2 20 evolution evolution NOUN 6m311n81j7k 2 21 has have AUX 6m311n81j7k 2 22 included include VERB 6m311n81j7k 2 23 a a DET 6m311n81j7k 2 24 wide wide ADJ 6m311n81j7k 2 25 variety variety NOUN 6m311n81j7k 2 26 of of ADP 6m311n81j7k 2 27 structural structural ADJ 6m311n81j7k 2 28 features feature NOUN 6m311n81j7k 2 29 designed design VERB 6m311n81j7k 2 30 to to PART 6m311n81j7k 2 31 limit limit VERB 6m311n81j7k 2 32 local local ADJ 6m311n81j7k 2 33 conformational conformational ADJ 6m311n81j7k 2 34 preferences preference NOUN 6m311n81j7k 2 35 . . PUNCT 6m311n81j7k 3 1 as as ADP 6m311n81j7k 3 2 such such ADJ 6m311n81j7k 3 3 , , PUNCT 6m311n81j7k 3 4 these these DET 6m311n81j7k 3 5 molecules molecule NOUN 6m311n81j7k 3 6 , , PUNCT 6m311n81j7k 3 7 particularly particularly ADV 6m311n81j7k 3 8 the the DET 6m311n81j7k 3 9 macrocyclic macrocyclic NOUN 6m311n81j7k 3 10 varieties variety NOUN 6m311n81j7k 3 11 , , PUNCT 6m311n81j7k 3 12 will will AUX 6m311n81j7k 3 13 adopt adopt VERB 6m311n81j7k 3 14 preferred preferred ADJ 6m311n81j7k 3 15 low low ADJ 6m311n81j7k 3 16 - - PUNCT 6m311n81j7k 3 17 energy energy NOUN 6m311n81j7k 3 18 conformations conformation NOUN 6m311n81j7k 3 19 . . PUNCT 6m311n81j7k 4 1 we we PRON 6m311n81j7k 4 2 believe believe VERB 6m311n81j7k 4 3 that that SCONJ 6m311n81j7k 4 4 understanding understand VERB 6m311n81j7k 4 5 these these DET 6m311n81j7k 4 6 preferences preference NOUN 6m311n81j7k 4 7 for for ADP 6m311n81j7k 4 8 a a DET 6m311n81j7k 4 9 given give VERB 6m311n81j7k 4 10 polyketide polyketide NOUN 6m311n81j7k 4 11 is be AUX 6m311n81j7k 4 12 a a DET 6m311n81j7k 4 13 necessary necessary ADJ 6m311n81j7k 4 14 precursor precursor NOUN 6m311n81j7k 4 15 to to ADP 6m311n81j7k 4 16 analogue analogue NOUN 6m311n81j7k 4 17 design design NOUN 6m311n81j7k 4 18 , , PUNCT 6m311n81j7k 4 19 as as SCONJ 6m311n81j7k 4 20 any any DET 6m311n81j7k 4 21 modifications modification NOUN 6m311n81j7k 4 22 to to ADP 6m311n81j7k 4 23 the the DET 6m311n81j7k 4 24 structure structure NOUN 6m311n81j7k 4 25 should should AUX 6m311n81j7k 4 26 be be AUX 6m311n81j7k 4 27 mindful mindful ADJ 6m311n81j7k 4 28 of of ADP 6m311n81j7k 4 29 how how SCONJ 6m311n81j7k 4 30 conformation conformation NOUN 6m311n81j7k 4 31 will will AUX 6m311n81j7k 4 32 be be AUX 6m311n81j7k 4 33 affected affect VERB 6m311n81j7k 4 34 . . PUNCT 6m311n81j7k 5 1 as as ADP 6m311n81j7k 5 2 such such ADJ 6m311n81j7k 5 3 , , PUNCT 6m311n81j7k 5 4 our our PRON 6m311n81j7k 5 5 research research NOUN 6m311n81j7k 5 6 uses use VERB 6m311n81j7k 5 7 techniques technique NOUN 6m311n81j7k 5 8 based base VERB 6m311n81j7k 5 9 around around ADP 6m311n81j7k 5 10 high high ADJ 6m311n81j7k 5 11 - - PUNCT 6m311n81j7k 5 12 field field NOUN 6m311n81j7k 5 13 nmr nmr NOUN 6m311n81j7k 5 14 and and CCONJ 6m311n81j7k 5 15 molecular molecular ADJ 6m311n81j7k 5 16 modeling model VERB 6m311n81j7k 5 17 experiments experiment NOUN 6m311n81j7k 5 18 to to PART 6m311n81j7k 5 19 analyze analyze VERB 6m311n81j7k 5 20 polyketide polyketide PROPN 6m311n81j7k 5 21 conformational conformational PROPN 6m311n81j7k 5 22 preferences.neopeltolide preferences.neopeltolide PROPN 6m311n81j7k 5 23 is be AUX 6m311n81j7k 5 24 a a DET 6m311n81j7k 5 25 14 14 NUM 6m311n81j7k 5 26 - - PUNCT 6m311n81j7k 5 27 membered membered ADJ 6m311n81j7k 5 28 marine marine PROPN 6m311n81j7k 5 29 polyketide polyketide NOUN 6m311n81j7k 5 30 natural natural ADJ 6m311n81j7k 5 31 product product NOUN 6m311n81j7k 5 32 that that PRON 6m311n81j7k 5 33 has have AUX 6m311n81j7k 5 34 demonstrated demonstrate VERB 6m311n81j7k 5 35 considerable considerable ADJ 6m311n81j7k 5 36 antifungal antifungal ADJ 6m311n81j7k 5 37 and and CCONJ 6m311n81j7k 5 38 anticancer anticancer NOUN 6m311n81j7k 5 39 potential potential NOUN 6m311n81j7k 5 40 . . PUNCT 6m311n81j7k 6 1 our our PRON 6m311n81j7k 6 2 conformational conformational ADJ 6m311n81j7k 6 3 analysis analysis NOUN 6m311n81j7k 6 4 of of ADP 6m311n81j7k 6 5 its its PRON 6m311n81j7k 6 6 macrolide macrolide NOUN 6m311n81j7k 6 7 found find VERB 6m311n81j7k 6 8 that that SCONJ 6m311n81j7k 6 9 it it PRON 6m311n81j7k 6 10 adopts adopt VERB 6m311n81j7k 6 11 a a DET 6m311n81j7k 6 12 single single ADJ 6m311n81j7k 6 13 conformation conformation NOUN 6m311n81j7k 6 14 in in ADP 6m311n81j7k 6 15 solution solution NOUN 6m311n81j7k 6 16 , , PUNCT 6m311n81j7k 6 17 which which PRON 6m311n81j7k 6 18 minimizes minimize VERB 6m311n81j7k 6 19 syn syn PROPN 6m311n81j7k 6 20 - - PUNCT 6m311n81j7k 6 21 pentane pentane ADJ 6m311n81j7k 6 22 interactions interaction NOUN 6m311n81j7k 6 23 between between ADP 6m311n81j7k 6 24 substituents substituent NOUN 6m311n81j7k 6 25 at at ADP 6m311n81j7k 6 26 the the DET 6m311n81j7k 6 27 c9 c9 ADJ 6m311n81j7k 6 28 , , PUNCT 6m311n81j7k 6 29 c11 c11 ADJ 6m311n81j7k 6 30 , , PUNCT 6m311n81j7k 6 31 and and CCONJ 6m311n81j7k 6 32 c13 c13 NOUN 6m311n81j7k 6 33 positions position NOUN 6m311n81j7k 6 34 . . PUNCT 6m311n81j7k 7 1 further further ADJ 6m311n81j7k 7 2 analyses analysis NOUN 6m311n81j7k 7 3 found find VERB 6m311n81j7k 7 4 that that SCONJ 6m311n81j7k 7 5 c2 c2 PROPN 6m311n81j7k 7 6 substitution substitution NOUN 6m311n81j7k 7 7 should should AUX 6m311n81j7k 7 8 not not PART 6m311n81j7k 7 9 affect affect VERB 6m311n81j7k 7 10 this this DET 6m311n81j7k 7 11 conformation conformation NOUN 6m311n81j7k 7 12 , , PUNCT 6m311n81j7k 7 13 and and CCONJ 6m311n81j7k 7 14 a a DET 6m311n81j7k 7 15 methyl methyl NOUN 6m311n81j7k 7 16 group group NOUN 6m311n81j7k 7 17 was be AUX 6m311n81j7k 7 18 attached attach VERB 6m311n81j7k 7 19 synthetically synthetically ADV 6m311n81j7k 7 20 to to PART 6m311n81j7k 7 21 probe probe VERB 6m311n81j7k 7 22 any any DET 6m311n81j7k 7 23 potential potential ADJ 6m311n81j7k 7 24 biological biological ADJ 6m311n81j7k 7 25 effects effect NOUN 6m311n81j7k 7 26 . . PUNCT 6m311n81j7k 8 1 additionally additionally ADV 6m311n81j7k 8 2 , , PUNCT 6m311n81j7k 8 3 a a DET 6m311n81j7k 8 4 preliminary preliminary ADJ 6m311n81j7k 8 5 analysis analysis NOUN 6m311n81j7k 8 6 was be AUX 6m311n81j7k 8 7 made make VERB 6m311n81j7k 8 8 of of ADP 6m311n81j7k 8 9 neopeltolide neopeltolide NOUN 6m311n81j7k 8 10 's 's PART 6m311n81j7k 8 11 purported purport VERB 6m311n81j7k 8 12 biological biological ADJ 6m311n81j7k 8 13 target target NOUN 6m311n81j7k 8 14 , , PUNCT 6m311n81j7k 8 15 cytochrome cytochrome NOUN 6m311n81j7k 8 16 bc1 bc1 PROPN 6m311n81j7k 8 17 , , PUNCT 6m311n81j7k 8 18 for for ADP 6m311n81j7k 8 19 potential potential ADJ 6m311n81j7k 8 20 binding bind VERB 6m311n81j7k 8 21 sites site NOUN 6m311n81j7k 8 22 , , PUNCT 6m311n81j7k 8 23 which which PRON 6m311n81j7k 8 24 found find VERB 6m311n81j7k 8 25 a a DET 6m311n81j7k 8 26 potentially potentially ADV 6m311n81j7k 8 27 new new ADJ 6m311n81j7k 8 28 allosteric allosteric NOUN 6m311n81j7k 8 29 region region NOUN 6m311n81j7k 8 30 that that PRON 6m311n81j7k 8 31 fits fit VERB 6m311n81j7k 8 32 neopeltolide neopeltolide ADV 6m311n81j7k 8 33 better well ADV 6m311n81j7k 8 34 than than ADP 6m311n81j7k 8 35 either either PRON 6m311n81j7k 8 36 of of ADP 6m311n81j7k 8 37 the the DET 6m311n81j7k 8 38 known know VERB 6m311n81j7k 8 39 sites site NOUN 6m311n81j7k 8 40 of of ADP 6m311n81j7k 8 41 inhibition.zampanolide inhibition.zampanolide NOUN 6m311n81j7k 8 42 and and CCONJ 6m311n81j7k 8 43 dactylolide dactylolide NOUN 6m311n81j7k 8 44 are be AUX 6m311n81j7k 8 45 related relate VERB 6m311n81j7k 8 46 20 20 NUM 6m311n81j7k 8 47 - - PUNCT 6m311n81j7k 8 48 membered membered ADJ 6m311n81j7k 8 49 marine marine ADJ 6m311n81j7k 8 50 polyketides polyketide NOUN 6m311n81j7k 8 51 that that PRON 6m311n81j7k 8 52 exhibit exhibit VERB 6m311n81j7k 8 53 considerable considerable ADJ 6m311n81j7k 8 54 cytotoxicity cytotoxicity NOUN 6m311n81j7k 8 55 against against ADP 6m311n81j7k 8 56 multiple multiple ADJ 6m311n81j7k 8 57 human human ADJ 6m311n81j7k 8 58 cancer cancer NOUN 6m311n81j7k 8 59 cell cell NOUN 6m311n81j7k 8 60 lines line NOUN 6m311n81j7k 8 61 and and CCONJ 6m311n81j7k 8 62 act act VERB 6m311n81j7k 8 63 as as ADP 6m311n81j7k 8 64 a a DET 6m311n81j7k 8 65 microtubule microtubule NOUN 6m311n81j7k 8 66 stabilizing stabilize VERB 6m311n81j7k 8 67 agents agent NOUN 6m311n81j7k 8 68 . . PUNCT 6m311n81j7k 9 1 our our PRON 6m311n81j7k 9 2 research research NOUN 6m311n81j7k 9 3 used use VERB 6m311n81j7k 9 4 material material NOUN 6m311n81j7k 9 5 from from ADP 6m311n81j7k 9 6 a a DET 6m311n81j7k 9 7 synthesis synthesis NOUN 6m311n81j7k 9 8 of of ADP 6m311n81j7k 9 9 dactylolide dactylolide NOUN 6m311n81j7k 9 10 to to PART 6m311n81j7k 9 11 elucidate elucidate VERB 6m311n81j7k 9 12 its its PRON 6m311n81j7k 9 13 solution solution NOUN 6m311n81j7k 9 14 structure structure NOUN 6m311n81j7k 9 15 and and CCONJ 6m311n81j7k 9 16 conformational conformational ADJ 6m311n81j7k 9 17 preferences preference NOUN 6m311n81j7k 9 18 . . PUNCT 6m311n81j7k 10 1 this this DET 6m311n81j7k 10 2 work work NOUN 6m311n81j7k 10 3 found find VERB 6m311n81j7k 10 4 that that SCONJ 6m311n81j7k 10 5 the the DET 6m311n81j7k 10 6 shared share VERB 6m311n81j7k 10 7 macrolide macrolide NOUN 6m311n81j7k 10 8 interconverts interconvert NOUN 6m311n81j7k 10 9 between between ADP 6m311n81j7k 10 10 three three NUM 6m311n81j7k 10 11 major major ADJ 6m311n81j7k 10 12 families family NOUN 6m311n81j7k 10 13 in in ADP 6m311n81j7k 10 14 dmso dmso PROPN 6m311n81j7k 10 15 - - PUNCT 6m311n81j7k 10 16 d6 d6 PROPN 6m311n81j7k 10 17 , , PUNCT 6m311n81j7k 10 18 one one NUM 6m311n81j7k 10 19 of of ADP 6m311n81j7k 10 20 which which PRON 6m311n81j7k 10 21 bears bear VERB 6m311n81j7k 10 22 considerable considerable ADJ 6m311n81j7k 10 23 resemblance resemblance NOUN 6m311n81j7k 10 24 to to ADP 6m311n81j7k 10 25 the the DET 6m311n81j7k 10 26 bound bound ADJ 6m311n81j7k 10 27 conformation conformation NOUN 6m311n81j7k 10 28 of of ADP 6m311n81j7k 10 29 zampanolide zampanolide PROPN 6m311n81j7k 10 30 . . PUNCT 6m311n81j7k 11 1 we we PRON 6m311n81j7k 11 2 used use VERB 6m311n81j7k 11 3 this this DET 6m311n81j7k 11 4 work work NOUN 6m311n81j7k 11 5 to to PART 6m311n81j7k 11 6 design design VERB 6m311n81j7k 11 7 a a DET 6m311n81j7k 11 8 simplified simplified ADJ 6m311n81j7k 11 9 analogue analogue NOUN 6m311n81j7k 11 10 that that PRON 6m311n81j7k 11 11 omits omit VERB 6m311n81j7k 11 12 the the DET 6m311n81j7k 11 13 c17 c17 NOUN 6m311n81j7k 11 14 methyl methyl NOUN 6m311n81j7k 11 15 and and CCONJ 6m311n81j7k 11 16 c13 c13 PROPN 6m311n81j7k 11 17 exocyclic exocyclic PROPN 6m311n81j7k 11 18 alkene alkene PROPN 6m311n81j7k 11 19 , , PUNCT 6m311n81j7k 11 20 which which PRON 6m311n81j7k 11 21 possessed possess VERB 6m311n81j7k 11 22 a a DET 6m311n81j7k 11 23 considerably considerably ADV 6m311n81j7k 11 24 shortened shorten VERB 6m311n81j7k 11 25 synthetic synthetic ADJ 6m311n81j7k 11 26 route route NOUN 6m311n81j7k 11 27 in in ADP 6m311n81j7k 11 28 comparison comparison NOUN 6m311n81j7k 11 29 with with ADP 6m311n81j7k 11 30 the the DET 6m311n81j7k 11 31 parent parent NOUN 6m311n81j7k 11 32 compound.finally compound.finally ADV 6m311n81j7k 11 33 , , PUNCT 6m311n81j7k 11 34 the the DET 6m311n81j7k 11 35 misidentification misidentification NOUN 6m311n81j7k 11 36 of of ADP 6m311n81j7k 11 37 the the DET 6m311n81j7k 11 38 bioactive bioactive ADJ 6m311n81j7k 11 39 conformation conformation NOUN 6m311n81j7k 11 40 of of ADP 6m311n81j7k 11 41 the the DET 6m311n81j7k 11 42 polyketide polyketide PROPN 6m311n81j7k 11 43 epothilone epothilone PROPN 6m311n81j7k 11 44 prompted prompt VERB 6m311n81j7k 11 45 us we PRON 6m311n81j7k 11 46 to to PART 6m311n81j7k 11 47 investigate investigate VERB 6m311n81j7k 11 48 whether whether SCONJ 6m311n81j7k 11 49 the the DET 6m311n81j7k 11 50 notable notable ADJ 6m311n81j7k 11 51 structural structural ADJ 6m311n81j7k 11 52 elements element NOUN 6m311n81j7k 11 53 that that PRON 6m311n81j7k 11 54 influence influence NOUN 6m311n81j7k 11 55 polyketide polyketide PROPN 6m311n81j7k 11 56 conformation conformation NOUN 6m311n81j7k 11 57 could could AUX 6m311n81j7k 11 58 be be AUX 6m311n81j7k 11 59 affected affect VERB 6m311n81j7k 11 60 by by ADP 6m311n81j7k 11 61 a a DET 6m311n81j7k 11 62 solid solid ADJ 6m311n81j7k 11 63 state state NOUN 6m311n81j7k 11 64 environment environment NOUN 6m311n81j7k 11 65 . . PUNCT 6m311n81j7k 12 1 this this DET 6m311n81j7k 12 2 research research NOUN 6m311n81j7k 12 3 involved involve VERB 6m311n81j7k 12 4 searching search VERB 6m311n81j7k 12 5 the the DET 6m311n81j7k 12 6 cambridge cambridge ADJ 6m311n81j7k 12 7 structural structural ADJ 6m311n81j7k 12 8 database database NOUN 6m311n81j7k 12 9 for for ADP 6m311n81j7k 12 10 a a DET 6m311n81j7k 12 11 variety variety NOUN 6m311n81j7k 12 12 of of ADP 6m311n81j7k 12 13 features feature NOUN 6m311n81j7k 12 14 , , PUNCT 6m311n81j7k 12 15 including include VERB 6m311n81j7k 12 16 syn syn ADJ 6m311n81j7k 12 17 - - PUNCT 6m311n81j7k 12 18 pentane pentane ADJ 6m311n81j7k 12 19 interactions interaction NOUN 6m311n81j7k 12 20 , , PUNCT 6m311n81j7k 12 21 the the DET 6m311n81j7k 12 22 gauche gauche PROPN 6m311n81j7k 12 23 effect effect NOUN 6m311n81j7k 12 24 , , PUNCT 6m311n81j7k 12 25 allylic allylic ADJ 6m311n81j7k 12 26 strain strain NOUN 6m311n81j7k 12 27 and and CCONJ 6m311n81j7k 12 28 others other NOUN 6m311n81j7k 12 29 . . PUNCT 6m311n81j7k 13 1 our our PRON 6m311n81j7k 13 2 results result NOUN 6m311n81j7k 13 3 found find VERB 6m311n81j7k 13 4 that that SCONJ 6m311n81j7k 13 5 high high ADJ 6m311n81j7k 13 6 - - PUNCT 6m311n81j7k 13 7 energy energy NOUN 6m311n81j7k 13 8 features feature NOUN 6m311n81j7k 13 9 relying rely VERB 6m311n81j7k 13 10 on on ADP 6m311n81j7k 13 11 steric steric ADJ 6m311n81j7k 13 12 effects effect NOUN 6m311n81j7k 13 13 will will AUX 6m311n81j7k 13 14 be be AUX 6m311n81j7k 13 15 unaffected unaffected ADJ 6m311n81j7k 13 16 by by ADP 6m311n81j7k 13 17 crystal crystal NOUN 6m311n81j7k 13 18 packing packing NOUN 6m311n81j7k 13 19 forces force NOUN 6m311n81j7k 13 20 , , PUNCT 6m311n81j7k 13 21 while while SCONJ 6m311n81j7k 13 22 features feature NOUN 6m311n81j7k 13 23 reliant reliant ADJ 6m311n81j7k 13 24 upon upon SCONJ 6m311n81j7k 13 25 lower low ADJ 6m311n81j7k 13 26 - - PUNCT 6m311n81j7k 13 27 energy energy NOUN 6m311n81j7k 13 28 stereoelectronic stereoelectronic ADJ 6m311n81j7k 13 29 effects effect NOUN 6m311n81j7k 13 30 or or CCONJ 6m311n81j7k 13 31 hydrogen hydrogen NOUN 6m311n81j7k 13 32 bonds bond NOUN 6m311n81j7k 13 33 were be AUX 6m311n81j7k 13 34 far far ADV 6m311n81j7k 13 35 more more ADV 6m311n81j7k 13 36 likely likely ADJ 6m311n81j7k 13 37 to to PART 6m311n81j7k 13 38 be be AUX 6m311n81j7k 13 39 influenced influence VERB 6m311n81j7k 13 40 . . PUNCT