id sid tid token lemma pos 6969z031n4s 1 1 members member NOUN 6969z031n4s 1 2 of of ADP 6969z031n4s 1 3 the the DET 6969z031n4s 1 4 mycobacterium mycobacterium NOUN 6969z031n4s 1 5 genus genus NOUN 6969z031n4s 1 6 present present VERB 6969z031n4s 1 7 a a DET 6969z031n4s 1 8 serious serious ADJ 6969z031n4s 1 9 health health NOUN 6969z031n4s 1 10 threat threat NOUN 6969z031n4s 1 11 which which PRON 6969z031n4s 1 12 account account VERB 6969z031n4s 1 13 for for ADP 6969z031n4s 1 14 significant significant ADJ 6969z031n4s 1 15 morbidity morbidity NOUN 6969z031n4s 1 16 and and CCONJ 6969z031n4s 1 17 mortality mortality NOUN 6969z031n4s 1 18 in in ADP 6969z031n4s 1 19 humans human NOUN 6969z031n4s 1 20 and and CCONJ 6969z031n4s 1 21 other other ADJ 6969z031n4s 1 22 species specie NOUN 6969z031n4s 1 23 . . PUNCT 6969z031n4s 2 1 many many ADJ 6969z031n4s 2 2 pathogenic pathogenic ADJ 6969z031n4s 2 3 mycobacterial mycobacterial ADJ 6969z031n4s 2 4 species specie NOUN 6969z031n4s 2 5 maintain maintain VERB 6969z031n4s 2 6 an an DET 6969z031n4s 2 7 intracellular intracellular ADJ 6969z031n4s 2 8 life life NOUN 6969z031n4s 2 9 style style NOUN 6969z031n4s 2 10 within within ADP 6969z031n4s 2 11 macrophages macrophage NOUN 6969z031n4s 2 12 serving serve VERB 6969z031n4s 2 13 as as ADP 6969z031n4s 2 14 the the DET 6969z031n4s 2 15 primary primary ADJ 6969z031n4s 2 16 host host NOUN 6969z031n4s 2 17 cell cell NOUN 6969z031n4s 2 18 . . PUNCT 6969z031n4s 3 1 the the DET 6969z031n4s 3 2 mycobacterium mycobacterium NOUN 6969z031n4s 3 3 's 's PART 6969z031n4s 3 4 ability ability NOUN 6969z031n4s 3 5 to to PART 6969z031n4s 3 6 modulate modulate VERB 6969z031n4s 3 7 the the DET 6969z031n4s 3 8 macrophage macrophage NOUN 6969z031n4s 3 9 function function NOUN 6969z031n4s 3 10 requires require VERB 6969z031n4s 3 11 the the DET 6969z031n4s 3 12 expression expression NOUN 6969z031n4s 3 13 of of ADP 6969z031n4s 3 14 specific specific ADJ 6969z031n4s 3 15 mycobacterial mycobacterial ADJ 6969z031n4s 3 16 surface surface NOUN 6969z031n4s 3 17 components component NOUN 6969z031n4s 3 18 . . PUNCT 6969z031n4s 4 1 moreover moreover ADV 6969z031n4s 4 2 , , PUNCT 6969z031n4s 4 3 a a DET 6969z031n4s 4 4 number number NOUN 6969z031n4s 4 5 of of ADP 6969z031n4s 4 6 studies study NOUN 6969z031n4s 4 7 have have AUX 6969z031n4s 4 8 shown show VERB 6969z031n4s 4 9 that that SCONJ 6969z031n4s 4 10 various various ADJ 6969z031n4s 4 11 mycobacterial mycobacterial ADJ 6969z031n4s 4 12 surface surface NOUN 6969z031n4s 4 13 components component NOUN 6969z031n4s 4 14 can can AUX 6969z031n4s 4 15 promote promote VERB 6969z031n4s 4 16 macrophage macrophage NOUN 6969z031n4s 4 17 activation activation NOUN 6969z031n4s 4 18 . . PUNCT 6969z031n4s 5 1 this this DET 6969z031n4s 5 2 dissertation dissertation NOUN 6969z031n4s 5 3 aims aim VERB 6969z031n4s 5 4 to to PART 6969z031n4s 5 5 define define VERB 6969z031n4s 5 6 the the DET 6969z031n4s 5 7 role role NOUN 6969z031n4s 5 8 of of ADP 6969z031n4s 5 9 glycopeptidolipids glycopeptidolipid NOUN 6969z031n4s 5 10 ( ( PUNCT 6969z031n4s 5 11 gpl gpl PROPN 6969z031n4s 5 12 ) ) PUNCT 6969z031n4s 5 13 , , PUNCT 6969z031n4s 5 14 which which PRON 6969z031n4s 5 15 are be AUX 6969z031n4s 5 16 highly highly ADV 6969z031n4s 5 17 antigenic antigenic ADJ 6969z031n4s 5 18 glycolipids glycolipid NOUN 6969z031n4s 5 19 , , PUNCT 6969z031n4s 5 20 in in ADP 6969z031n4s 5 21 the the DET 6969z031n4s 5 22 immune immune NOUN 6969z031n4s 5 23 - - PUNCT 6969z031n4s 5 24 modulation modulation NOUN 6969z031n4s 5 25 of of ADP 6969z031n4s 5 26 the the DET 6969z031n4s 5 27 host host NOUN 6969z031n4s 5 28 and and CCONJ 6969z031n4s 5 29 thus thus ADV 6969z031n4s 5 30 establish establish VERB 6969z031n4s 5 31 its its PRON 6969z031n4s 5 32 function function NOUN 6969z031n4s 5 33 as as ADP 6969z031n4s 5 34 an an DET 6969z031n4s 5 35 important important ADJ 6969z031n4s 5 36 virulence virulence NOUN 6969z031n4s 5 37 factor factor NOUN 6969z031n4s 5 38 . . PUNCT 6969z031n4s 6 1 to to PART 6969z031n4s 6 2 address address VERB 6969z031n4s 6 3 the the DET 6969z031n4s 6 4 role role NOUN 6969z031n4s 6 5 of of ADP 6969z031n4s 6 6 gpl gpl NOUN 6969z031n4s 6 7 as as ADP 6969z031n4s 6 8 a a DET 6969z031n4s 6 9 virulence virulence NOUN 6969z031n4s 6 10 factor factor NOUN 6969z031n4s 6 11 , , PUNCT 6969z031n4s 6 12 we we PRON 6969z031n4s 6 13 utilized utilize VERB 6969z031n4s 6 14 m. m. NOUN 6969z031n4s 6 15 avium avium NOUN 6969z031n4s 6 16 strains strain VERB 6969z031n4s 6 17 either either CCONJ 6969z031n4s 6 18 naturally naturally ADV 6969z031n4s 6 19 lacking lack VERB 6969z031n4s 6 20 gpl gpl ADJ 6969z031n4s 6 21 expression expression NOUN 6969z031n4s 6 22 or or CCONJ 6969z031n4s 6 23 genetically genetically ADV 6969z031n4s 6 24 altered alter VERB 6969z031n4s 6 25 to to PART 6969z031n4s 6 26 express express VERB 6969z031n4s 6 27 modified modify VERB 6969z031n4s 6 28 gpl gpl NOUN 6969z031n4s 6 29 . . PUNCT 6969z031n4s 7 1 our our PRON 6969z031n4s 7 2 studies study NOUN 6969z031n4s 7 3 showed show VERB 6969z031n4s 7 4 that that SCONJ 6969z031n4s 7 5 the the DET 6969z031n4s 7 6 loss loss NOUN 6969z031n4s 7 7 of of ADP 6969z031n4s 7 8 gpl gpl NOUN 6969z031n4s 7 9 or or CCONJ 6969z031n4s 7 10 altering alter VERB 6969z031n4s 7 11 its its PRON 6969z031n4s 7 12 structure structure NOUN 6969z031n4s 7 13 leads lead VERB 6969z031n4s 7 14 to to ADP 6969z031n4s 7 15 an an DET 6969z031n4s 7 16 m. m. NOUN 6969z031n4s 7 17 avium avium NOUN 6969z031n4s 7 18 strain strain NOUN 6969z031n4s 7 19 which which PRON 6969z031n4s 7 20 induces induce VERB 6969z031n4s 7 21 increased increase VERB 6969z031n4s 7 22 macrophage macrophage NOUN 6969z031n4s 7 23 activation activation NOUN 6969z031n4s 7 24 compared compare VERB 6969z031n4s 7 25 to to ADP 6969z031n4s 7 26 gpl gpl ADJ 6969z031n4s 7 27 sufficient sufficient ADJ 6969z031n4s 7 28 m. m. NOUN 6969z031n4s 7 29 avium avium NOUN 6969z031n4s 7 30 strains strain NOUN 6969z031n4s 7 31 . . PUNCT 6969z031n4s 8 1 additional additional ADJ 6969z031n4s 8 2 analysis analysis NOUN 6969z031n4s 8 3 showed show VERB 6969z031n4s 8 4 attenuated attenuate VERB 6969z031n4s 8 5 virulence virulence NOUN 6969z031n4s 8 6 of of ADP 6969z031n4s 8 7 gpl gpl NOUN 6969z031n4s 8 8 - - PUNCT 6969z031n4s 8 9 deficient deficient ADJ 6969z031n4s 8 10 / / SYM 6969z031n4s 8 11 modified modify VERB 6969z031n4s 8 12 m. m. NOUN 6969z031n4s 8 13 avium avium NOUN 6969z031n4s 8 14 strains strain VERB 6969z031n4s 8 15 in in ADP 6969z031n4s 8 16 a a DET 6969z031n4s 8 17 mouse mouse NOUN 6969z031n4s 8 18 infection infection NOUN 6969z031n4s 8 19 model model NOUN 6969z031n4s 8 20 . . PUNCT 6969z031n4s 9 1 to to PART 6969z031n4s 9 2 further far ADV 6969z031n4s 9 3 understand understand VERB 6969z031n4s 9 4 the the DET 6969z031n4s 9 5 mechanism mechanism NOUN 6969z031n4s 9 6 of of ADP 6969z031n4s 9 7 action action NOUN 6969z031n4s 9 8 of of ADP 6969z031n4s 9 9 gpl gpl PROPN 6969z031n4s 9 10 , , PUNCT 6969z031n4s 9 11 we we PRON 6969z031n4s 9 12 investigated investigate VERB 6969z031n4s 9 13 the the DET 6969z031n4s 9 14 trafficking trafficking NOUN 6969z031n4s 9 15 of of ADP 6969z031n4s 9 16 gpl gpl PROPN 6969z031n4s 9 17 in in ADP 6969z031n4s 9 18 primary primary ADJ 6969z031n4s 9 19 macrophages macrophage NOUN 6969z031n4s 9 20 infected infect VERB 6969z031n4s 9 21 with with ADP 6969z031n4s 9 22 m. m. NOUN 6969z031n4s 9 23 avium avium NOUN 6969z031n4s 9 24 . . PUNCT 6969z031n4s 10 1 our our PRON 6969z031n4s 10 2 studies study NOUN 6969z031n4s 10 3 revealed reveal VERB 6969z031n4s 10 4 significant significant ADJ 6969z031n4s 10 5 release release NOUN 6969z031n4s 10 6 and and CCONJ 6969z031n4s 10 7 trafficking trafficking NOUN 6969z031n4s 10 8 of of ADP 6969z031n4s 10 9 gpl gpl NOUN 6969z031n4s 10 10 from from ADP 6969z031n4s 10 11 the the DET 6969z031n4s 10 12 mycobacteria mycobacteria NOUN 6969z031n4s 10 13 containing contain VERB 6969z031n4s 10 14 phagosome phagosome ADJ 6969z031n4s 10 15 to to ADP 6969z031n4s 10 16 a a DET 6969z031n4s 10 17 distinct distinct ADJ 6969z031n4s 10 18 endocytic endocytic ADJ 6969z031n4s 10 19 compartment compartment NOUN 6969z031n4s 10 20 called call VERB 6969z031n4s 10 21 the the DET 6969z031n4s 10 22 multivesicular multivesicular ADJ 6969z031n4s 10 23 bodies body NOUN 6969z031n4s 10 24 ( ( PUNCT 6969z031n4s 10 25 mvb mvb PROPN 6969z031n4s 10 26 ) ) PUNCT 6969z031n4s 10 27 . . PUNCT 6969z031n4s 11 1 additional additional ADJ 6969z031n4s 11 2 analysis analysis NOUN 6969z031n4s 11 3 showed show VERB 6969z031n4s 11 4 that that SCONJ 6969z031n4s 11 5 mycobacterial mycobacterial ADJ 6969z031n4s 11 6 components component NOUN 6969z031n4s 11 7 including include VERB 6969z031n4s 11 8 gpl gpl PROPN 6969z031n4s 11 9 are be AUX 6969z031n4s 11 10 trafficked traffic VERB 6969z031n4s 11 11 outside outside ADP 6969z031n4s 11 12 the the DET 6969z031n4s 11 13 infected infected ADJ 6969z031n4s 11 14 cells cell NOUN 6969z031n4s 11 15 on on ADP 6969z031n4s 11 16 ' ' PUNCT 6969z031n4s 11 17 exosomes exosome NOUN 6969z031n4s 11 18 . . PUNCT 6969z031n4s 11 19 ' ' PUNCT 6969z031n4s 11 20 further far ADV 6969z031n4s 11 21 , , PUNCT 6969z031n4s 11 22 we we PRON 6969z031n4s 11 23 determined determine VERB 6969z031n4s 11 24 that that SCONJ 6969z031n4s 11 25 exosomes exosome NOUN 6969z031n4s 11 26 purified purify VERB 6969z031n4s 11 27 from from ADP 6969z031n4s 11 28 the the DET 6969z031n4s 11 29 culture culture NOUN 6969z031n4s 11 30 supernatants supernatant NOUN 6969z031n4s 11 31 of of ADP 6969z031n4s 11 32 macrophages macrophage NOUN 6969z031n4s 11 33 infected infect VERB 6969z031n4s 11 34 with with ADP 6969z031n4s 11 35 m. m. NOUN 6969z031n4s 11 36 avium avium NOUN 6969z031n4s 11 37 , , PUNCT 6969z031n4s 11 38 m. m. NOUN 6969z031n4s 11 39 tuberculosis tuberculosis NOUN 6969z031n4s 11 40 h37rv h37rv NOUN 6969z031n4s 11 41 or or CCONJ 6969z031n4s 11 42 m. m. PROPN 6969z031n4s 11 43 bovis bovis PROPN 6969z031n4s 11 44 bcg bcg PROPN 6969z031n4s 11 45 stimulate stimulate VERB 6969z031n4s 11 46 a a DET 6969z031n4s 11 47 pro pro ADJ 6969z031n4s 11 48 - - ADJ 6969z031n4s 11 49 inflammatory inflammatory ADJ 6969z031n4s 11 50 response response NOUN 6969z031n4s 11 51 in in ADP 6969z031n4s 11 52 uninfected uninfected ADJ 6969z031n4s 11 53 macrophages macrophage NOUN 6969z031n4s 11 54 . . PUNCT 6969z031n4s 12 1 our our PRON 6969z031n4s 12 2 studies study NOUN 6969z031n4s 12 3 are be AUX 6969z031n4s 12 4 first first ADJ 6969z031n4s 12 5 to to PART 6969z031n4s 12 6 establish establish VERB 6969z031n4s 12 7 gpl gpl PROPN 6969z031n4s 12 8 's 's PART 6969z031n4s 12 9 importance importance NOUN 6969z031n4s 12 10 as as ADP 6969z031n4s 12 11 a a DET 6969z031n4s 12 12 virulence virulence NOUN 6969z031n4s 12 13 factor factor NOUN 6969z031n4s 12 14 in in ADP 6969z031n4s 12 15 the the DET 6969z031n4s 12 16 m. m. NOUN 6969z031n4s 12 17 avium avium NOUN 6969z031n4s 12 18 pathogenesis pathogenesis NOUN 6969z031n4s 12 19 . . PUNCT 6969z031n4s 13 1 the the DET 6969z031n4s 13 2 data datum NOUN 6969z031n4s 13 3 demonstrate demonstrate VERB 6969z031n4s 13 4 a a DET 6969z031n4s 13 5 significant significant ADJ 6969z031n4s 13 6 shedding shedding NOUN 6969z031n4s 13 7 of of ADP 6969z031n4s 13 8 glycopeptidolipids glycopeptidolipid NOUN 6969z031n4s 13 9 in in ADP 6969z031n4s 13 10 m. m. NOUN 6969z031n4s 13 11 avium avium NOUN 6969z031n4s 13 12 infected infect VERB 6969z031n4s 13 13 macrophages macrophage NOUN 6969z031n4s 13 14 and and CCONJ 6969z031n4s 13 15 its its PRON 6969z031n4s 13 16 transport transport NOUN 6969z031n4s 13 17 to to ADP 6969z031n4s 13 18 the the DET 6969z031n4s 13 19 neighboring neighboring NOUN 6969z031n4s 13 20 ' ' PUNCT 6969z031n4s 13 21 bystander bystander NOUN 6969z031n4s 13 22 cells cell NOUN 6969z031n4s 13 23 ' ' PUNCT 6969z031n4s 13 24 . . PUNCT 6969z031n4s 14 1 this this DET 6969z031n4s 14 2 transport transport NOUN 6969z031n4s 14 3 of of ADP 6969z031n4s 14 4 mycobacterial mycobacterial ADJ 6969z031n4s 14 5 components component NOUN 6969z031n4s 14 6 occur occur VERB 6969z031n4s 14 7 through through ADP 6969z031n4s 14 8 release release NOUN 6969z031n4s 14 9 of of ADP 6969z031n4s 14 10 exosomes exosome NOUN 6969z031n4s 14 11 extracellularly extracellularly ADV 6969z031n4s 14 12 which which PRON 6969z031n4s 14 13 can can AUX 6969z031n4s 14 14 also also ADV 6969z031n4s 14 15 act act VERB 6969z031n4s 14 16 to to PART 6969z031n4s 14 17 stimulate stimulate VERB 6969z031n4s 14 18 uninfected uninfected ADJ 6969z031n4s 14 19 macrophages macrophage NOUN 6969z031n4s 14 20 both both CCONJ 6969z031n4s 14 21 in in ADP 6969z031n4s 14 22 vitro vitro X 6969z031n4s 14 23 and and CCONJ 6969z031n4s 14 24 in in ADP 6969z031n4s 14 25 vivo vivo PROPN 6969z031n4s 14 26 . . PROPN 6969z031n4s 15 1 together together ADV 6969z031n4s 15 2 , , PUNCT 6969z031n4s 15 3 our our PRON 6969z031n4s 15 4 studies study NOUN 6969z031n4s 15 5 put put VERB 6969z031n4s 15 6 forward forward ADP 6969z031n4s 15 7 a a DET 6969z031n4s 15 8 novel novel ADJ 6969z031n4s 15 9 mechanism mechanism NOUN 6969z031n4s 15 10 of of ADP 6969z031n4s 15 11 intercellular intercellular ADJ 6969z031n4s 15 12 communication communication NOUN 6969z031n4s 15 13 mediated mediate VERB 6969z031n4s 15 14 by by ADP 6969z031n4s 15 15 exosomes exosome NOUN 6969z031n4s 15 16 which which PRON 6969z031n4s 15 17 can can AUX 6969z031n4s 15 18 carry carry VERB 6969z031n4s 15 19 mycobacterial mycobacterial ADJ 6969z031n4s 15 20 components component NOUN 6969z031n4s 15 21 to to ADP 6969z031n4s 15 22 neighboring neighboring NOUN 6969z031n4s 15 23 cells cell NOUN 6969z031n4s 15 24 . . PUNCT