id sid tid token lemma pos 6682x349c6x 1 1 breast breast NOUN 6682x349c6x 1 2 cancer cancer NOUN 6682x349c6x 1 3 is be AUX 6682x349c6x 1 4 the the DET 6682x349c6x 1 5 most most ADV 6682x349c6x 1 6 diagnosed diagnose VERB 6682x349c6x 1 7 cancer cancer NOUN 6682x349c6x 1 8 in in ADP 6682x349c6x 1 9 women woman NOUN 6682x349c6x 1 10 , , PUNCT 6682x349c6x 1 11 affecting affect VERB 6682x349c6x 1 12 one one NUM 6682x349c6x 1 13 in in ADP 6682x349c6x 1 14 eight eight NUM 6682x349c6x 1 15 women woman NOUN 6682x349c6x 1 16 in in ADP 6682x349c6x 1 17 the the DET 6682x349c6x 1 18 united united PROPN 6682x349c6x 1 19 states states PROPN 6682x349c6x 1 20 , , PUNCT 6682x349c6x 1 21 and and CCONJ 6682x349c6x 1 22 is be AUX 6682x349c6x 1 23 the the DET 6682x349c6x 1 24 leading lead VERB 6682x349c6x 1 25 cause cause NOUN 6682x349c6x 1 26 of of ADP 6682x349c6x 1 27 cancer cancer NOUN 6682x349c6x 1 28 related relate VERB 6682x349c6x 1 29 deaths death NOUN 6682x349c6x 1 30 , , PUNCT 6682x349c6x 1 31 second second ADV 6682x349c6x 1 32 only only ADV 6682x349c6x 1 33 to to ADP 6682x349c6x 1 34 lung lung NOUN 6682x349c6x 1 35 cancer cancer NOUN 6682x349c6x 1 36 . . PUNCT 6682x349c6x 2 1 metastatic metastatic ADJ 6682x349c6x 2 2 breast breast NOUN 6682x349c6x 2 3 cancer cancer NOUN 6682x349c6x 2 4 tumors tumor NOUN 6682x349c6x 2 5 , , PUNCT 6682x349c6x 2 6 rather rather ADV 6682x349c6x 2 7 than than ADP 6682x349c6x 2 8 the the DET 6682x349c6x 2 9 primary primary ADJ 6682x349c6x 2 10 tumors tumor NOUN 6682x349c6x 2 11 themselves themselves PRON 6682x349c6x 2 12 , , PUNCT 6682x349c6x 2 13 contribute contribute VERB 6682x349c6x 2 14 to to ADP 6682x349c6x 2 15 the the DET 6682x349c6x 2 16 patient patient NOUN 6682x349c6x 2 17 's 's PART 6682x349c6x 2 18 death death NOUN 6682x349c6x 2 19 . . PUNCT 6682x349c6x 3 1 the the DET 6682x349c6x 3 2 most most ADV 6682x349c6x 3 3 common common ADJ 6682x349c6x 3 4 tissue tissue NOUN 6682x349c6x 3 5 for for ADP 6682x349c6x 3 6 breast breast NOUN 6682x349c6x 3 7 cancer cancer NOUN 6682x349c6x 3 8 to to PART 6682x349c6x 3 9 metastasize metastasize VERB 6682x349c6x 3 10 is be AUX 6682x349c6x 3 11 bone bone NOUN 6682x349c6x 3 12 . . PUNCT 6682x349c6x 4 1 a a DET 6682x349c6x 4 2 major major ADJ 6682x349c6x 4 3 challenge challenge NOUN 6682x349c6x 4 4 in in ADP 6682x349c6x 4 5 the the DET 6682x349c6x 4 6 study study NOUN 6682x349c6x 4 7 of of ADP 6682x349c6x 4 8 breast breast NOUN 6682x349c6x 4 9 cancer cancer NOUN 6682x349c6x 4 10 metastasis metastasis NOUN 6682x349c6x 4 11 to to ADP 6682x349c6x 4 12 bone bone NOUN 6682x349c6x 4 13 is be AUX 6682x349c6x 4 14 the the DET 6682x349c6x 4 15 lack lack NOUN 6682x349c6x 4 16 of of ADP 6682x349c6x 4 17 experimental experimental ADJ 6682x349c6x 4 18 models model NOUN 6682x349c6x 4 19 that that PRON 6682x349c6x 4 20 target target VERB 6682x349c6x 4 21 the the DET 6682x349c6x 4 22 last last ADJ 6682x349c6x 4 23 steps step NOUN 6682x349c6x 4 24 of of ADP 6682x349c6x 4 25 the the DET 6682x349c6x 4 26 metastatic metastatic ADJ 6682x349c6x 4 27 cascade cascade NOUN 6682x349c6x 4 28 in in ADP 6682x349c6x 4 29 the the DET 6682x349c6x 4 30 context context NOUN 6682x349c6x 4 31 of of ADP 6682x349c6x 4 32 the the DET 6682x349c6x 4 33 bone bone NOUN 6682x349c6x 4 34 microenvironment microenvironment NOUN 6682x349c6x 4 35 . . PUNCT 6682x349c6x 5 1 in in ADP 6682x349c6x 5 2 this this DET 6682x349c6x 5 3 thesis thesis NOUN 6682x349c6x 5 4 , , PUNCT 6682x349c6x 5 5 i i PRON 6682x349c6x 5 6 developed develop VERB 6682x349c6x 5 7 a a DET 6682x349c6x 5 8 novel novel ADJ 6682x349c6x 5 9 methodology methodology NOUN 6682x349c6x 5 10 to to PART 6682x349c6x 5 11 study study VERB 6682x349c6x 5 12 breast breast NOUN 6682x349c6x 5 13 cancer cancer NOUN 6682x349c6x 5 14 metastasis metastasis NOUN 6682x349c6x 5 15 to to ADP 6682x349c6x 5 16 the the DET 6682x349c6x 5 17 bone bone NOUN 6682x349c6x 5 18 ex ex NOUN 6682x349c6x 5 19 vivo vivo PROPN 6682x349c6x 5 20 . . PUNCT 6682x349c6x 6 1 after after ADP 6682x349c6x 6 2 validation validation NOUN 6682x349c6x 6 3 of of ADP 6682x349c6x 6 4 this this DET 6682x349c6x 6 5 model model NOUN 6682x349c6x 6 6 as as ADP 6682x349c6x 6 7 a a DET 6682x349c6x 6 8 useful useful ADJ 6682x349c6x 6 9 tool tool NOUN 6682x349c6x 6 10 for for ADP 6682x349c6x 6 11 cancer cancer NOUN 6682x349c6x 6 12 research research NOUN 6682x349c6x 6 13 , , PUNCT 6682x349c6x 6 14 i i PRON 6682x349c6x 6 15 used use VERB 6682x349c6x 6 16 it it PRON 6682x349c6x 6 17 to to PART 6682x349c6x 6 18 study study VERB 6682x349c6x 6 19 the the DET 6682x349c6x 6 20 effects effect NOUN 6682x349c6x 6 21 of of ADP 6682x349c6x 6 22 paracrine paracrine NOUN 6682x349c6x 6 23 signals signal NOUN 6682x349c6x 6 24 sent send VERB 6682x349c6x 6 25 by by ADP 6682x349c6x 6 26 the the DET 6682x349c6x 6 27 bone bone NOUN 6682x349c6x 6 28 , , PUNCT 6682x349c6x 6 29 marrow marrow NOUN 6682x349c6x 6 30 , , PUNCT 6682x349c6x 6 31 and and CCONJ 6682x349c6x 6 32 cancer cancer NOUN 6682x349c6x 6 33 cells cell NOUN 6682x349c6x 6 34 to to PART 6682x349c6x 6 35 promote promote VERB 6682x349c6x 6 36 bone bone NOUN 6682x349c6x 6 37 colonization colonization NOUN 6682x349c6x 6 38 . . PUNCT 6682x349c6x 7 1 with with ADP 6682x349c6x 7 2 our our PRON 6682x349c6x 7 3 system system NOUN 6682x349c6x 7 4 , , PUNCT 6682x349c6x 7 5 i i PRON 6682x349c6x 7 6 identified identify VERB 6682x349c6x 7 7 multiple multiple ADJ 6682x349c6x 7 8 cytokines cytokine NOUN 6682x349c6x 7 9 and and CCONJ 6682x349c6x 7 10 chemokines chemokine NOUN 6682x349c6x 7 11 as as ADP 6682x349c6x 7 12 potential potential ADJ 6682x349c6x 7 13 players player NOUN 6682x349c6x 7 14 in in ADP 6682x349c6x 7 15 the the DET 6682x349c6x 7 16 progression progression NOUN 6682x349c6x 7 17 of of ADP 6682x349c6x 7 18 breast breast NOUN 6682x349c6x 7 19 cancer cancer NOUN 6682x349c6x 7 20 metastasis metastasis NOUN 6682x349c6x 7 21 to to ADP 6682x349c6x 7 22 the the DET 6682x349c6x 7 23 bone bone NOUN 6682x349c6x 7 24 including include VERB 6682x349c6x 7 25 cxcl5 cxcl5 PROPN 6682x349c6x 7 26 , , PUNCT 6682x349c6x 7 27 cxcl2 cxcl2 PROPN 6682x349c6x 7 28 , , PUNCT 6682x349c6x 7 29 cxcl10 cxcl10 SPACE 6682x349c6x 7 30 , , PUNCT 6682x349c6x 7 31 tnfa tnfa NOUN 6682x349c6x 7 32 , , PUNCT 6682x349c6x 7 33 and and CCONJ 6682x349c6x 7 34 vegf vegf PROPN 6682x349c6x 7 35 . . PROPN 6682x349c6x 8 1 proteins protein NOUN 6682x349c6x 8 2 associated associate VERB 6682x349c6x 8 3 with with ADP 6682x349c6x 8 4 cancer cancer NOUN 6682x349c6x 8 5 initiation initiation NOUN 6682x349c6x 8 6 , , PUNCT 6682x349c6x 8 7 growth growth NOUN 6682x349c6x 8 8 , , PUNCT 6682x349c6x 8 9 emt emt NOUN 6682x349c6x 8 10 , , PUNCT 6682x349c6x 8 11 and and CCONJ 6682x349c6x 8 12 metastasis metastasis NOUN 6682x349c6x 8 13 . . PUNCT 6682x349c6x 9 1 i i PRON 6682x349c6x 9 2 studied study VERB 6682x349c6x 9 3 the the DET 6682x349c6x 9 4 effects effect NOUN 6682x349c6x 9 5 of of ADP 6682x349c6x 9 6 cxcl5 cxcl5 PROPN 6682x349c6x 9 7 in in ADP 6682x349c6x 9 8 our our PRON 6682x349c6x 9 9 co co ADJ 6682x349c6x 9 10 - - ADJ 6682x349c6x 9 11 culture culture ADJ 6682x349c6x 9 12 system system NOUN 6682x349c6x 9 13 of of ADP 6682x349c6x 9 14 bone bone NOUN 6682x349c6x 9 15 and and CCONJ 6682x349c6x 9 16 cancer cancer NOUN 6682x349c6x 9 17 cells cell NOUN 6682x349c6x 9 18 . . PUNCT 6682x349c6x 10 1 cxcl5 cxcl5 PROPN 6682x349c6x 10 2 is be AUX 6682x349c6x 10 3 part part NOUN 6682x349c6x 10 4 of of ADP 6682x349c6x 10 5 the the DET 6682x349c6x 10 6 elr+ elr+ NOUN 6682x349c6x 10 7 subfamily subfamily NOUN 6682x349c6x 10 8 of of ADP 6682x349c6x 10 9 chemokines chemokine NOUN 6682x349c6x 10 10 and and CCONJ 6682x349c6x 10 11 interacts interact VERB 6682x349c6x 10 12 with with ADP 6682x349c6x 10 13 cxcr2 cxcr2 PROPN 6682x349c6x 10 14 , , PUNCT 6682x349c6x 10 15 which which PRON 6682x349c6x 10 16 is be AUX 6682x349c6x 10 17 cxcl5 cxcl5 PROPN 6682x349c6x 10 18 's 's PART 6682x349c6x 10 19 only only ADV 6682x349c6x 10 20 known know VERB 6682x349c6x 10 21 functional functional ADJ 6682x349c6x 10 22 receptor receptor NOUN 6682x349c6x 10 23 . . PUNCT 6682x349c6x 11 1 i i PRON 6682x349c6x 11 2 discovered discover VERB 6682x349c6x 11 3 that that SCONJ 6682x349c6x 11 4 bone bone NOUN 6682x349c6x 11 5 co co NOUN 6682x349c6x 11 6 - - NOUN 6682x349c6x 11 7 cultures culture NOUN 6682x349c6x 11 8 of of ADP 6682x349c6x 11 9 cancer cancer NOUN 6682x349c6x 11 10 cells cell NOUN 6682x349c6x 11 11 with with ADP 6682x349c6x 11 12 cancer cancer NOUN 6682x349c6x 11 13 - - PUNCT 6682x349c6x 11 14 primed prime VERB 6682x349c6x 11 15 bone bone NOUN 6682x349c6x 11 16 induce induce VERB 6682x349c6x 11 17 cancer cancer NOUN 6682x349c6x 11 18 colonization colonization NOUN 6682x349c6x 11 19 and and CCONJ 6682x349c6x 11 20 secrete secrete VERB 6682x349c6x 11 21 higher high ADJ 6682x349c6x 11 22 levels level NOUN 6682x349c6x 11 23 of of ADP 6682x349c6x 11 24 cxcl5 cxcl5 PROPN 6682x349c6x 11 25 into into ADP 6682x349c6x 11 26 the the DET 6682x349c6x 11 27 culture culture NOUN 6682x349c6x 11 28 media medium NOUN 6682x349c6x 11 29 when when SCONJ 6682x349c6x 11 30 compared compare VERB 6682x349c6x 11 31 to to ADP 6682x349c6x 11 32 co co NOUN 6682x349c6x 11 33 - - NOUN 6682x349c6x 11 34 cultures culture NOUN 6682x349c6x 11 35 using use VERB 6682x349c6x 11 36 healthy healthy ADJ 6682x349c6x 11 37 bones bone NOUN 6682x349c6x 11 38 . . PUNCT 6682x349c6x 12 1 moreover moreover ADV 6682x349c6x 12 2 , , PUNCT 6682x349c6x 12 3 addition addition NOUN 6682x349c6x 12 4 of of ADP 6682x349c6x 12 5 exogenous exogenous ADJ 6682x349c6x 12 6 cxcl5 cxcl5 PROPN 6682x349c6x 12 7 to to ADP 6682x349c6x 12 8 co co NOUN 6682x349c6x 12 9 - - NOUN 6682x349c6x 12 10 cultures culture NOUN 6682x349c6x 12 11 is be AUX 6682x349c6x 12 12 sufficient sufficient ADJ 6682x349c6x 12 13 to to PART 6682x349c6x 12 14 promote promote VERB 6682x349c6x 12 15 cancer cancer NOUN 6682x349c6x 12 16 cell cell NOUN 6682x349c6x 12 17 proliferation proliferation NOUN 6682x349c6x 12 18 and and CCONJ 6682x349c6x 12 19 bone bone NOUN 6682x349c6x 12 20 colonization colonization NOUN 6682x349c6x 12 21 in in ADP 6682x349c6x 12 22 co co NOUN 6682x349c6x 12 23 - - NOUN 6682x349c6x 12 24 culture culture NOUN 6682x349c6x 12 25 . . PUNCT 6682x349c6x 13 1 furthermore furthermore ADV 6682x349c6x 13 2 , , PUNCT 6682x349c6x 13 3 blocking block VERB 6682x349c6x 13 4 cxcr2 cxcr2 NOUN 6682x349c6x 13 5 also also ADV 6682x349c6x 13 6 reduces reduce VERB 6682x349c6x 13 7 cancer cancer NOUN 6682x349c6x 13 8 cell cell NOUN 6682x349c6x 13 9 proliferation proliferation NOUN 6682x349c6x 13 10 and and CCONJ 6682x349c6x 13 11 inhibits inhibit VERB 6682x349c6x 13 12 metastatic metastatic ADJ 6682x349c6x 13 13 colonization colonization NOUN 6682x349c6x 13 14 of of ADP 6682x349c6x 13 15 the the DET 6682x349c6x 13 16 bone.this bone.this NOUN 6682x349c6x 13 17 study study NOUN 6682x349c6x 13 18 provides provide VERB 6682x349c6x 13 19 a a DET 6682x349c6x 13 20 new new ADJ 6682x349c6x 13 21 experimental experimental ADJ 6682x349c6x 13 22 platform platform NOUN 6682x349c6x 13 23 that that PRON 6682x349c6x 13 24 will will AUX 6682x349c6x 13 25 allow allow VERB 6682x349c6x 13 26 us we PRON 6682x349c6x 13 27 to to PART 6682x349c6x 13 28 better well ADV 6682x349c6x 13 29 understand understand VERB 6682x349c6x 13 30 what what PRON 6682x349c6x 13 31 drives drive VERB 6682x349c6x 13 32 cancer cancer NOUN 6682x349c6x 13 33 to to PART 6682x349c6x 13 34 metastasize metastasize VERB 6682x349c6x 13 35 to to ADP 6682x349c6x 13 36 bone bone NOUN 6682x349c6x 13 37 and and CCONJ 6682x349c6x 13 38 , , PUNCT 6682x349c6x 13 39 thus thus ADV 6682x349c6x 13 40 , , PUNCT 6682x349c6x 13 41 to to PART 6682x349c6x 13 42 develop develop VERB 6682x349c6x 13 43 better well ADJ 6682x349c6x 13 44 treatment treatment NOUN 6682x349c6x 13 45 options option NOUN 6682x349c6x 13 46 for for ADP 6682x349c6x 13 47 patients patient NOUN 6682x349c6x 13 48 with with ADP 6682x349c6x 13 49 bone bone NOUN 6682x349c6x 13 50 metastasis metastasis NOUN 6682x349c6x 13 51 . . PUNCT