id sid tid token lemma pos 6395w66545j 1 1 the the DET 6395w66545j 1 2 cell cell NOUN 6395w66545j 1 3 - - PUNCT 6395w66545j 1 4 mediated mediate VERB 6395w66545j 1 5 immune immune ADJ 6395w66545j 1 6 response response NOUN 6395w66545j 1 7 is be AUX 6395w66545j 1 8 the the DET 6395w66545j 1 9 branch branch NOUN 6395w66545j 1 10 of of ADP 6395w66545j 1 11 the the DET 6395w66545j 1 12 adaptive adaptive ADJ 6395w66545j 1 13 immune immune ADJ 6395w66545j 1 14 system system NOUN 6395w66545j 1 15 responsible responsible ADJ 6395w66545j 1 16 for for ADP 6395w66545j 1 17 recognizing recognize VERB 6395w66545j 1 18 and and CCONJ 6395w66545j 1 19 destroying destroy VERB 6395w66545j 1 20 infected infected ADJ 6395w66545j 1 21 cells cell NOUN 6395w66545j 1 22 . . PUNCT 6395w66545j 2 1 t t NOUN 6395w66545j 2 2 lymphocytes lymphocyte NOUN 6395w66545j 2 3 express express VERB 6395w66545j 2 4 the the DET 6395w66545j 2 5 surface surface NOUN 6395w66545j 2 6 protein protein NOUN 6395w66545j 2 7 t t PROPN 6395w66545j 2 8 cell cell NOUN 6395w66545j 2 9 receptor receptor NOUN 6395w66545j 2 10 ( ( PUNCT 6395w66545j 2 11 tcr tcr PROPN 6395w66545j 2 12 ) ) PUNCT 6395w66545j 2 13 which which PRON 6395w66545j 2 14 interacts interact VERB 6395w66545j 2 15 with with ADP 6395w66545j 2 16 a a DET 6395w66545j 2 17 major major ADJ 6395w66545j 2 18 histocompatibility histocompatibility NOUN 6395w66545j 2 19 complex complex NOUN 6395w66545j 2 20 ( ( PUNCT 6395w66545j 2 21 mhc mhc NOUN 6395w66545j 2 22 ) ) PUNCT 6395w66545j 2 23 presenting present VERB 6395w66545j 2 24 a a DET 6395w66545j 2 25 peptide peptide NOUN 6395w66545j 2 26 on on ADP 6395w66545j 2 27 the the DET 6395w66545j 2 28 surface surface NOUN 6395w66545j 2 29 of of ADP 6395w66545j 2 30 antigen antigen NOUN 6395w66545j 2 31 presenting present VERB 6395w66545j 2 32 cells cell NOUN 6395w66545j 2 33 . . PUNCT 6395w66545j 3 1 while while SCONJ 6395w66545j 3 2 tcrs tcr NOUN 6395w66545j 3 3 display display VERB 6395w66545j 3 4 a a DET 6395w66545j 3 5 level level NOUN 6395w66545j 3 6 of of ADP 6395w66545j 3 7 cross cross NOUN 6395w66545j 3 8 reactivity reactivity NOUN 6395w66545j 3 9 to to PART 6395w66545j 3 10 ensure ensure VERB 6395w66545j 3 11 adequate adequate ADJ 6395w66545j 3 12 coverage coverage NOUN 6395w66545j 3 13 of of ADP 6395w66545j 3 14 peptide peptide NOUN 6395w66545j 3 15 / / SYM 6395w66545j 3 16 mhc mhc NOUN 6395w66545j 3 17 ( ( PUNCT 6395w66545j 3 18 pmhc pmhc PROPN 6395w66545j 3 19 ) ) PUNCT 6395w66545j 3 20 , , PUNCT 6395w66545j 3 21 they they PRON 6395w66545j 3 22 are be AUX 6395w66545j 3 23 also also ADV 6395w66545j 3 24 restricted restrict VERB 6395w66545j 3 25 to to ADP 6395w66545j 3 26 recognizing recognize VERB 6395w66545j 3 27 epitopes epitope NOUN 6395w66545j 3 28 within within ADP 6395w66545j 3 29 the the DET 6395w66545j 3 30 context context NOUN 6395w66545j 3 31 of of ADP 6395w66545j 3 32 an an DET 6395w66545j 3 33 mhc mhc NOUN 6395w66545j 3 34 . . PUNCT 6395w66545j 4 1 this this DET 6395w66545j 4 2 so so ADV 6395w66545j 4 3 - - PUNCT 6395w66545j 4 4 called call VERB 6395w66545j 4 5 mhc mhc NOUN 6395w66545j 4 6 bias bias NOUN 6395w66545j 4 7 has have AUX 6395w66545j 4 8 been be AUX 6395w66545j 4 9 studied study VERB 6395w66545j 4 10 for for ADP 6395w66545j 4 11 decades decade NOUN 6395w66545j 4 12 , , PUNCT 6395w66545j 4 13 with with ADP 6395w66545j 4 14 many many ADJ 6395w66545j 4 15 theories theory NOUN 6395w66545j 4 16 emerging emerge VERB 6395w66545j 4 17 as as ADP 6395w66545j 4 18 to to ADP 6395w66545j 4 19 why why SCONJ 6395w66545j 4 20 tcrs tcr NOUN 6395w66545j 4 21 might might AUX 6395w66545j 4 22 display display VERB 6395w66545j 4 23 such such ADJ 6395w66545j 4 24 blatant blatant ADJ 6395w66545j 4 25 favoritism favoritism NOUN 6395w66545j 4 26 . . PUNCT 6395w66545j 5 1 while while SCONJ 6395w66545j 5 2 structures structure NOUN 6395w66545j 5 3 of of ADP 6395w66545j 5 4 tcr tcr PROPN 6395w66545j 5 5 - - PUNCT 6395w66545j 5 6 pmhc pmhc NOUN 6395w66545j 5 7 complexes complex NOUN 6395w66545j 5 8 have have AUX 6395w66545j 5 9 failed fail VERB 6395w66545j 5 10 to to PART 6395w66545j 5 11 identify identify VERB 6395w66545j 5 12 any any DET 6395w66545j 5 13 conserved conserved ADJ 6395w66545j 5 14 interactions interaction NOUN 6395w66545j 5 15 between between ADP 6395w66545j 5 16 tcr tcr NOUN 6395w66545j 5 17 and and CCONJ 6395w66545j 5 18 mhc mhc NOUN 6395w66545j 5 19 [ [ X 6395w66545j 5 20 1 1 NUM 6395w66545j 5 21 ] ] PUNCT 6395w66545j 5 22 , , PUNCT 6395w66545j 5 23 the the DET 6395w66545j 5 24 existence existence NOUN 6395w66545j 5 25 of of ADP 6395w66545j 5 26 coreceptor coreceptor NOUN 6395w66545j 5 27 - - PUNCT 6395w66545j 5 28 independent independent ADJ 6395w66545j 5 29 tcr tcr PROPN 6395w66545j 5 30 - - PUNCT 6395w66545j 5 31 pmhc pmhc NOUN 6395w66545j 5 32 interactions interaction NOUN 6395w66545j 5 33 muddles muddle VERB 6395w66545j 5 34 their their PRON 6395w66545j 5 35 role role NOUN 6395w66545j 5 36 in in ADP 6395w66545j 5 37 imparting impart VERB 6395w66545j 5 38 mhc mhc NOUN 6395w66545j 5 39 bias bias NOUN 6395w66545j 5 40 for for ADP 6395w66545j 5 41 proper proper ADJ 6395w66545j 5 42 signaling signal VERB 6395w66545j 5 43 [ [ X 6395w66545j 5 44 2 2 NUM 6395w66545j 5 45 ] ] PUNCT 6395w66545j 5 46 . . PUNCT 6395w66545j 6 1 what what PRON 6395w66545j 6 2 has have AUX 6395w66545j 6 3 become become VERB 6395w66545j 6 4 clear clear ADJ 6395w66545j 6 5 is be AUX 6395w66545j 6 6 that that SCONJ 6395w66545j 6 7 the the DET 6395w66545j 6 8 original original ADJ 6395w66545j 6 9 " " PUNCT 6395w66545j 6 10 rules rule NOUN 6395w66545j 6 11 of of ADP 6395w66545j 6 12 engagement engagement NOUN 6395w66545j 6 13 " " PUNCT 6395w66545j 6 14 for for ADP 6395w66545j 6 15 tcr tcr PROPN 6395w66545j 6 16 - - PUNCT 6395w66545j 6 17 pmhc pmhc PROPN 6395w66545j 6 18 interactions interaction NOUN 6395w66545j 6 19 are be AUX 6395w66545j 6 20 evolving evolve VERB 6395w66545j 6 21 as as SCONJ 6395w66545j 6 22 new new ADJ 6395w66545j 6 23 biophysical biophysical ADJ 6395w66545j 6 24 , , PUNCT 6395w66545j 6 25 structural structural ADJ 6395w66545j 6 26 , , PUNCT 6395w66545j 6 27 and and CCONJ 6395w66545j 6 28 immunological immunological ADJ 6395w66545j 6 29 data datum NOUN 6395w66545j 6 30 becomes become VERB 6395w66545j 6 31 available available ADJ 6395w66545j 6 32 . . PUNCT 6395w66545j 7 1 to to ADP 6395w66545j 7 2 this this DET 6395w66545j 7 3 end end NOUN 6395w66545j 7 4 , , PUNCT 6395w66545j 7 5 we we PRON 6395w66545j 7 6 have have AUX 6395w66545j 7 7 taken take VERB 6395w66545j 7 8 some some PRON 6395w66545j 7 9 of of ADP 6395w66545j 7 10 the the DET 6395w66545j 7 11 core core ADJ 6395w66545j 7 12 ideas idea NOUN 6395w66545j 7 13 about about ADP 6395w66545j 7 14 tcr tcr PROPN 6395w66545j 7 15 - - PUNCT 6395w66545j 7 16 pmhc pmhc PROPN 6395w66545j 7 17 interactions interaction NOUN 6395w66545j 7 18 and and CCONJ 6395w66545j 7 19 studied study VERB 6395w66545j 7 20 them they PRON 6395w66545j 7 21 further far ADV 6395w66545j 7 22 . . PUNCT 6395w66545j 8 1 up up ADV 6395w66545j 8 2 until until ADP 6395w66545j 8 3 recently recently ADV 6395w66545j 8 4 , , PUNCT 6395w66545j 8 5 all all DET 6395w66545j 8 6 evidence evidence NOUN 6395w66545j 8 7 pointing point VERB 6395w66545j 8 8 towards towards ADP 6395w66545j 8 9 conserved conserve VERB 6395w66545j 8 10 tcr tcr PROPN 6395w66545j 8 11 - - PUNCT 6395w66545j 8 12 mhc mhc PROPN 6395w66545j 8 13 interactions interaction NOUN 6395w66545j 8 14 was be AUX 6395w66545j 8 15 based base VERB 6395w66545j 8 16 on on ADP 6395w66545j 8 17 structural structural ADJ 6395w66545j 8 18 study study NOUN 6395w66545j 8 19 . . PUNCT 6395w66545j 9 1 we we PRON 6395w66545j 9 2 decided decide VERB 6395w66545j 9 3 to to PART 6395w66545j 9 4 look look VERB 6395w66545j 9 5 from from ADP 6395w66545j 9 6 a a DET 6395w66545j 9 7 different different ADJ 6395w66545j 9 8 perspective perspective NOUN 6395w66545j 9 9 by by ADP 6395w66545j 9 10 studying study VERB 6395w66545j 9 11 the the DET 6395w66545j 9 12 sequence sequence NOUN 6395w66545j 9 13 information information NOUN 6395w66545j 9 14 for for ADP 6395w66545j 9 15 cdr cdr ADJ 6395w66545j 9 16 loops loop NOUN 6395w66545j 9 17 of of ADP 6395w66545j 9 18 t t PROPN 6395w66545j 9 19 cell cell NOUN 6395w66545j 9 20 receptors receptor NOUN 6395w66545j 9 21 . . PUNCT 6395w66545j 10 1 this this PRON 6395w66545j 10 2 yielded yield VERB 6395w66545j 10 3 tremendous tremendous ADJ 6395w66545j 10 4 insight insight NOUN 6395w66545j 10 5 and and CCONJ 6395w66545j 10 6 confirmed confirm VERB 6395w66545j 10 7 that that SCONJ 6395w66545j 10 8 tcr tcr NOUN 6395w66545j 10 9 interfaces interface NOUN 6395w66545j 10 10 are be AUX 6395w66545j 10 11 largely largely ADV 6395w66545j 10 12 unique unique ADJ 6395w66545j 10 13 yet yet CCONJ 6395w66545j 10 14 contain contain VERB 6395w66545j 10 15 enrichment enrichment NOUN 6395w66545j 10 16 for for ADP 6395w66545j 10 17 specific specific ADJ 6395w66545j 10 18 charged charge VERB 6395w66545j 10 19 residues residue NOUN 6395w66545j 10 20 that that PRON 6395w66545j 10 21 may may AUX 6395w66545j 10 22 facilitate facilitate VERB 6395w66545j 10 23 binding binding NOUN 6395w66545j 10 24 to to ADP 6395w66545j 10 25 particular particular ADJ 6395w66545j 10 26 hla hla ADJ 6395w66545j 10 27 alleles allele NOUN 6395w66545j 10 28 . . PUNCT 6395w66545j 11 1 we we PRON 6395w66545j 11 2 have have AUX 6395w66545j 11 3 also also ADV 6395w66545j 11 4 explored explore VERB 6395w66545j 11 5 the the DET 6395w66545j 11 6 roles role NOUN 6395w66545j 11 7 that that PRON 6395w66545j 11 8 a a DET 6395w66545j 11 9 single single ADJ 6395w66545j 11 10 conserved conserve VERB 6395w66545j 11 11 tcr tcr NOUN 6395w66545j 11 12 residue residue NOUN 6395w66545j 11 13 might might AUX 6395w66545j 11 14 have have VERB 6395w66545j 11 15 for for ADP 6395w66545j 11 16 pmhc pmhc NOUN 6395w66545j 11 17 recognition recognition NOUN 6395w66545j 11 18 . . PUNCT 6395w66545j 12 1 while while SCONJ 6395w66545j 12 2 being be AUX 6395w66545j 12 3 important important ADJ 6395w66545j 12 4 for for ADP 6395w66545j 12 5 proper proper ADJ 6395w66545j 12 6 recognition recognition NOUN 6395w66545j 12 7 of of ADP 6395w66545j 12 8 pmhc pmhc PROPN 6395w66545j 12 9 , , PUNCT 6395w66545j 12 10 both both PRON 6395w66545j 12 11 structural structural ADJ 6395w66545j 12 12 and and CCONJ 6395w66545j 12 13 fluorescence fluorescence ADJ 6395w66545j 12 14 anisotropy anisotropy NOUN 6395w66545j 12 15 data datum NOUN 6395w66545j 12 16 suggests suggest VERB 6395w66545j 12 17 this this DET 6395w66545j 12 18 residue residue NOUN 6395w66545j 12 19 may may AUX 6395w66545j 12 20 be be AUX 6395w66545j 12 21 exerting exert VERB 6395w66545j 12 22 its its PRON 6395w66545j 12 23 influence influence NOUN 6395w66545j 12 24 by by ADP 6395w66545j 12 25 maintaining maintain VERB 6395w66545j 12 26 the the DET 6395w66545j 12 27 cdr cdr ADJ 6395w66545j 12 28 loop loop NOUN 6395w66545j 12 29 conformations conformation NOUN 6395w66545j 12 30 or or CCONJ 6395w66545j 12 31 flexibility flexibility NOUN 6395w66545j 12 32 necessary necessary ADJ 6395w66545j 12 33 for for ADP 6395w66545j 12 34 recognition recognition NOUN 6395w66545j 12 35 . . PUNCT 6395w66545j 13 1 other other ADJ 6395w66545j 13 2 areas area NOUN 6395w66545j 13 3 , , PUNCT 6395w66545j 13 4 such such ADJ 6395w66545j 13 5 as as ADP 6395w66545j 13 6 immunological immunological ADJ 6395w66545j 13 7 or or CCONJ 6395w66545j 13 8 genetic genetic ADJ 6395w66545j 13 9 roles role NOUN 6395w66545j 13 10 might might AUX 6395w66545j 13 11 also also ADV 6395w66545j 13 12 explain explain VERB 6395w66545j 13 13 its its PRON 6395w66545j 13 14 conservation conservation NOUN 6395w66545j 13 15 . . PUNCT 6395w66545j 14 1 these these DET 6395w66545j 14 2 results result NOUN 6395w66545j 14 3 paint paint VERB 6395w66545j 14 4 a a DET 6395w66545j 14 5 more more ADV 6395w66545j 14 6 complex complex ADJ 6395w66545j 14 7 picture picture NOUN 6395w66545j 14 8 of of ADP 6395w66545j 14 9 tcr tcr PROPN 6395w66545j 14 10 - - PUNCT 6395w66545j 14 11 pmhc pmhc PROPN 6395w66545j 14 12 interactions interaction NOUN 6395w66545j 14 13 than than SCONJ 6395w66545j 14 14 was be AUX 6395w66545j 14 15 originally originally ADV 6395w66545j 14 16 hypothesized hypothesize VERB 6395w66545j 14 17 to to PART 6395w66545j 14 18 exist exist VERB 6395w66545j 14 19 . . PUNCT 6395w66545j 15 1 still still ADV 6395w66545j 15 2 , , PUNCT 6395w66545j 15 3 most most ADJ 6395w66545j 15 4 of of ADP 6395w66545j 15 5 the the DET 6395w66545j 15 6 findings finding NOUN 6395w66545j 15 7 make make VERB 6395w66545j 15 8 sense sense NOUN 6395w66545j 15 9 in in ADP 6395w66545j 15 10 biochemical biochemical ADJ 6395w66545j 15 11 and and CCONJ 6395w66545j 15 12 biophysical biophysical ADJ 6395w66545j 15 13 terms term NOUN 6395w66545j 15 14 , , PUNCT 6395w66545j 15 15 highlighting highlight VERB 6395w66545j 15 16 a a DET 6395w66545j 15 17 need need NOUN 6395w66545j 15 18 for for ADP 6395w66545j 15 19 more more ADJ 6395w66545j 15 20 experimentation experimentation NOUN 6395w66545j 15 21 in in ADP 6395w66545j 15 22 these these DET 6395w66545j 15 23 fields field NOUN 6395w66545j 15 24 to to PART 6395w66545j 15 25 truly truly ADV 6395w66545j 15 26 understand understand VERB 6395w66545j 15 27 the the DET 6395w66545j 15 28 functioning functioning NOUN 6395w66545j 15 29 of of ADP 6395w66545j 15 30 the the DET 6395w66545j 15 31 adaptive adaptive ADJ 6395w66545j 15 32 immune immune ADJ 6395w66545j 15 33 system.1 system.1 PROPN 6395w66545j 15 34 . . PROPN 6395w66545j 15 35 marrack marrack PROPN 6395w66545j 15 36 , , PUNCT 6395w66545j 15 37 p. p. PROPN 6395w66545j 15 38 , , PUNCT 6395w66545j 15 39 et et PROPN 6395w66545j 15 40 al al PROPN 6395w66545j 15 41 . . PROPN 6395w66545j 15 42 , , PUNCT 6395w66545j 15 43 evolutionarily evolutionarily ADV 6395w66545j 15 44 conserved conserve VERB 6395w66545j 15 45 amino amino ADJ 6395w66545j 15 46 acids acid NOUN 6395w66545j 15 47 in in ADP 6395w66545j 15 48 tcr tcr PROPN 6395w66545j 15 49 v v ADP 6395w66545j 15 50 regions region NOUN 6395w66545j 15 51 and and CCONJ 6395w66545j 15 52 mhc mhc ADV 6395w66545j 15 53 control control VERB 6395w66545j 15 54 their their PRON 6395w66545j 15 55 interaction interaction NOUN 6395w66545j 15 56 . . PUNCT 6395w66545j 16 1 annual annual ADJ 6395w66545j 16 2 review review NOUN 6395w66545j 16 3 of of ADP 6395w66545j 16 4 immunology immunology NOUN 6395w66545j 16 5 , , PUNCT 6395w66545j 16 6 2008 2008 NUM 6395w66545j 16 7 . . PUNCT 6395w66545j 17 1 26 26 NUM 6395w66545j 17 2 : : PUNCT 6395w66545j 17 3 p. p. NOUN 6395w66545j 17 4 1712 1712 NUM 6395w66545j 17 5 . . PUNCT 6395w66545j 18 1 kerry kerry PROPN 6395w66545j 18 2 , , PUNCT 6395w66545j 18 3 s.e s.e PROPN 6395w66545j 18 4 . . PROPN 6395w66545j 18 5 , , PUNCT 6395w66545j 18 6 et et PROPN 6395w66545j 18 7 al al PROPN 6395w66545j 18 8 . . PROPN 6395w66545j 18 9 , , PUNCT 6395w66545j 18 10 interplay interplay NOUN 6395w66545j 18 11 between between ADP 6395w66545j 18 12 tcr tcr NOUN 6395w66545j 18 13 affinity affinity NOUN 6395w66545j 18 14 and and CCONJ 6395w66545j 18 15 necessity necessity NOUN 6395w66545j 18 16 of of ADP 6395w66545j 18 17 coreceptor coreceptor NOUN 6395w66545j 18 18 ligation ligation NOUN 6395w66545j 18 19 : : PUNCT 6395w66545j 18 20 high high ADJ 6395w66545j 18 21 - - PUNCT 6395w66545j 18 22 affinity affinity NOUN 6395w66545j 18 23 peptide peptide NOUN 6395w66545j 18 24 - - PUNCT 6395w66545j 18 25 mhc mhc NOUN 6395w66545j 18 26 / / SYM 6395w66545j 18 27 tcr tcr PROPN 6395w66545j 18 28 interaction interaction NOUN 6395w66545j 18 29 overcomes overcome VERB 6395w66545j 18 30 lack lack NOUN 6395w66545j 18 31 of of ADP 6395w66545j 18 32 cd8 cd8 PROPN 6395w66545j 18 33 engagement engagement NOUN 6395w66545j 18 34 . . PUNCT 6395w66545j 19 1 the the DET 6395w66545j 19 2 journal journal NOUN 6395w66545j 19 3 of of ADP 6395w66545j 19 4 immunology immunology NOUN 6395w66545j 19 5 , , PUNCT 6395w66545j 19 6 2003 2003 NUM 6395w66545j 19 7 . . PUNCT 6395w66545j 20 1 171(9 171(9 NUM 6395w66545j 20 2 ): ): PUNCT 6395w66545j 20 3 p. p. NOUN 6395w66545j 20 4 4493 4493 NUM 6395w66545j 20 5 - - SYM 6395w66545j 20 6 4503 4503 NUM