id sid tid token lemma pos 6395w665357 1 1 lipids lipid NOUN 6395w665357 1 2 participate participate VERB 6395w665357 1 3 in in ADP 6395w665357 1 4 cellular cellular ADJ 6395w665357 1 5 homeostasis homeostasis NOUN 6395w665357 1 6 through through ADP 6395w665357 1 7 selective selective ADJ 6395w665357 1 8 interactions interaction NOUN 6395w665357 1 9 with with ADP 6395w665357 1 10 proteins protein NOUN 6395w665357 1 11 , , PUNCT 6395w665357 1 12 by by ADP 6395w665357 1 13 functioning function VERB 6395w665357 1 14 as as ADP 6395w665357 1 15 second second ADJ 6395w665357 1 16 messengers messenger NOUN 6395w665357 1 17 in in ADP 6395w665357 1 18 signaling signal VERB 6395w665357 1 19 processes process NOUN 6395w665357 1 20 and and CCONJ 6395w665357 1 21 through through ADP 6395w665357 1 22 the the DET 6395w665357 1 23 generation generation NOUN 6395w665357 1 24 of of ADP 6395w665357 1 25 cellular cellular ADJ 6395w665357 1 26 compartments compartment NOUN 6395w665357 1 27 to to PART 6395w665357 1 28 transfer transfer VERB 6395w665357 1 29 cargo cargo NOUN 6395w665357 1 30 between between ADP 6395w665357 1 31 organelles organelle NOUN 6395w665357 1 32 . . PUNCT 6395w665357 2 1 the the DET 6395w665357 2 2 focus focus NOUN 6395w665357 2 3 of of ADP 6395w665357 2 4 this this DET 6395w665357 2 5 thesis thesis NOUN 6395w665357 2 6 is be AUX 6395w665357 2 7 on on ADP 6395w665357 2 8 the the DET 6395w665357 2 9 peripheral peripheral ADJ 6395w665357 2 10 protein protein NOUN 6395w665357 2 11 cytosolic cytosolic NOUN 6395w665357 2 12 phospholipase phospholipase NOUN 6395w665357 2 13 a2 a2 PROPN 6395w665357 2 14 & & CCONJ 6395w665357 2 15 # # SYM 6395w665357 2 16 945 945 NUM 6395w665357 2 17 ; ; PUNCT 6395w665357 2 18 ( ( PUNCT 6395w665357 2 19 cpla2α cpla2α X 6395w665357 2 20 ;) ;) PROPN 6395w665357 2 21 that that PRON 6395w665357 2 22 participates participate VERB 6395w665357 2 23 in in ADP 6395w665357 2 24 all all DET 6395w665357 2 25 three three NUM 6395w665357 2 26 of of ADP 6395w665357 2 27 these these DET 6395w665357 2 28 functions function NOUN 6395w665357 2 29 of of ADP 6395w665357 2 30 lipids lipid NOUN 6395w665357 2 31 . . PUNCT 6395w665357 3 1 cpla2α cpla2α ADP 6395w665357 3 2 ; ; PUNCT 6395w665357 3 3 generates generate VERB 6395w665357 3 4 the the DET 6395w665357 3 5 lipid lipid NOUN 6395w665357 3 6 metabolite metabolite PROPN 6395w665357 3 7 arachidonic arachidonic PROPN 6395w665357 3 8 acid acid PROPN 6395w665357 3 9 ( ( PUNCT 6395w665357 3 10 aa aa NOUN 6395w665357 3 11 ) ) PUNCT 6395w665357 3 12 by by ADP 6395w665357 3 13 hydrolyzing hydrolyzing NOUN 6395w665357 3 14 phosphatidylcholine phosphatidylcholine NOUN 6395w665357 3 15 at at ADP 6395w665357 3 16 the the DET 6395w665357 3 17 sn-2 sn-2 PRON 6395w665357 3 18 position position NOUN 6395w665357 3 19 . . PUNCT 6395w665357 4 1 aa aa PROPN 6395w665357 4 2 is be AUX 6395w665357 4 3 then then ADV 6395w665357 4 4 further far ADV 6395w665357 4 5 metabolized metabolize VERB 6395w665357 4 6 by by ADP 6395w665357 4 7 cyclooxygenase cyclooxygenase PROPN 6395w665357 4 8 ( ( PUNCT 6395w665357 4 9 cox cox PROPN 6395w665357 4 10 ) ) PUNCT 6395w665357 4 11 1 1 NUM 6395w665357 4 12 and and CCONJ 6395w665357 4 13 cox cox NOUN 6395w665357 4 14 2 2 NUM 6395w665357 4 15 to to PART 6395w665357 4 16 generate generate VERB 6395w665357 4 17 prostaglandins prostaglandin NOUN 6395w665357 4 18 ( ( PUNCT 6395w665357 4 19 pgs pgs NOUN 6395w665357 4 20 ) ) PUNCT 6395w665357 4 21 and and CCONJ 6395w665357 4 22 by by ADP 6395w665357 4 23 lipoxygenases lipoxygenase NOUN 6395w665357 4 24 to to PART 6395w665357 4 25 generate generate VERB 6395w665357 4 26 leukotrienes leukotriene NOUN 6395w665357 4 27 ( ( PUNCT 6395w665357 4 28 lts lts PROPN 6395w665357 4 29 ) ) PUNCT 6395w665357 4 30 , , PUNCT 6395w665357 4 31 which which PRON 6395w665357 4 32 play play VERB 6395w665357 4 33 both both CCONJ 6395w665357 4 34 homeostatic homeostatic ADJ 6395w665357 4 35 and and CCONJ 6395w665357 4 36 pathological pathological ADJ 6395w665357 4 37 roles role NOUN 6395w665357 4 38 . . PUNCT 6395w665357 5 1 this this PRON 6395w665357 5 2 cpla2α cpla2α ADP 6395w665357 5 3 ; ; PUNCT 6395w665357 5 4 signaling signaling NOUN 6395w665357 5 5 has have AUX 6395w665357 5 6 been be AUX 6395w665357 5 7 implicated implicate VERB 6395w665357 5 8 in in ADP 6395w665357 5 9 cancer cancer NOUN 6395w665357 5 10 , , PUNCT 6395w665357 5 11 allergy allergy NOUN 6395w665357 5 12 , , PUNCT 6395w665357 5 13 asthma asthma NOUN 6395w665357 5 14 , , PUNCT 6395w665357 5 15 arthritis arthritis NOUN 6395w665357 5 16 and and CCONJ 6395w665357 5 17 heart heart NOUN 6395w665357 5 18 disease disease NOUN 6395w665357 5 19 , , PUNCT 6395w665357 5 20 causing cause VERB 6395w665357 5 21 cpla2α cpla2α ADP 6395w665357 5 22 ; ; PUNCT 6395w665357 5 23 to to PART 6395w665357 5 24 become become VERB 6395w665357 5 25 a a DET 6395w665357 5 26 high high ADJ 6395w665357 5 27 profile profile NOUN 6395w665357 5 28 therapeutic therapeutic ADJ 6395w665357 5 29 target target NOUN 6395w665357 5 30 in in ADP 6395w665357 5 31 the the DET 6395w665357 5 32 literature literature NOUN 6395w665357 5 33 . . PUNCT 6395w665357 6 1 the the DET 6395w665357 6 2 enzyme enzyme NOUN 6395w665357 6 3 is be AUX 6395w665357 6 4 composed compose VERB 6395w665357 6 5 of of ADP 6395w665357 6 6 two two NUM 6395w665357 6 7 domains domain NOUN 6395w665357 6 8 : : PUNCT 6395w665357 6 9 a a DET 6395w665357 6 10 c c X 6395w665357 6 11 - - PUNCT 6395w665357 6 12 terminal terminal ADJ 6395w665357 6 13 catalytic catalytic ADJ 6395w665357 6 14 domain domain NOUN 6395w665357 6 15 and and CCONJ 6395w665357 6 16 an an DET 6395w665357 6 17 n n ADJ 6395w665357 6 18 - - PUNCT 6395w665357 6 19 terminal terminal ADJ 6395w665357 6 20 lipid lipid NOUN 6395w665357 6 21 binding binding NOUN 6395w665357 6 22 conserved conserve VERB 6395w665357 6 23 2 2 NUM 6395w665357 6 24 ( ( PUNCT 6395w665357 6 25 c2 c2 PROPN 6395w665357 6 26 ) ) PUNCT 6395w665357 6 27 domain domain NOUN 6395w665357 6 28 . . PUNCT 6395w665357 7 1 our our PRON 6395w665357 7 2 initial initial ADJ 6395w665357 7 3 aim aim NOUN 6395w665357 7 4 was be AUX 6395w665357 7 5 focused focus VERB 6395w665357 7 6 on on ADP 6395w665357 7 7 developing develop VERB 6395w665357 7 8 a a DET 6395w665357 7 9 better well ADJ 6395w665357 7 10 understanding understanding NOUN 6395w665357 7 11 of of ADP 6395w665357 7 12 the the DET 6395w665357 7 13 ceramide-1 ceramide-1 PROPN 6395w665357 7 14 - - PUNCT 6395w665357 7 15 phosphate phosphate PROPN 6395w665357 7 16 ( ( PUNCT 6395w665357 7 17 c1p c1p SPACE 6395w665357 7 18 ) ) PUNCT 6395w665357 7 19 recognition recognition NOUN 6395w665357 7 20 within within ADP 6395w665357 7 21 the the DET 6395w665357 7 22 cpla2α cpla2α NOUN 6395w665357 7 23 ; ; PUNCT 6395w665357 7 24 c2 c2 PROPN 6395w665357 7 25 domain domain NOUN 6395w665357 7 26 , , PUNCT 6395w665357 7 27 as as SCONJ 6395w665357 7 28 it it PRON 6395w665357 7 29 has have AUX 6395w665357 7 30 been be AUX 6395w665357 7 31 implicated implicate VERB 6395w665357 7 32 in in ADP 6395w665357 7 33 the the DET 6395w665357 7 34 regulation regulation NOUN 6395w665357 7 35 of of ADP 6395w665357 7 36 the the DET 6395w665357 7 37 enzyme enzyme NOUN 6395w665357 7 38 's 's PART 6395w665357 7 39 activity activity NOUN 6395w665357 7 40 . . PUNCT 6395w665357 8 1 in in ADP 6395w665357 8 2 this this DET 6395w665357 8 3 study study NOUN 6395w665357 8 4 , , PUNCT 6395w665357 8 5 we we PRON 6395w665357 8 6 identified identify VERB 6395w665357 8 7 the the DET 6395w665357 8 8 molecular molecular ADJ 6395w665357 8 9 basis basis NOUN 6395w665357 8 10 of of ADP 6395w665357 8 11 the the DET 6395w665357 8 12 first first ADJ 6395w665357 8 13 c1p c1p NOUN 6395w665357 8 14 binding bind VERB 6395w665357 8 15 site site NOUN 6395w665357 8 16 primarily primarily ADV 6395w665357 8 17 through through ADP 6395w665357 8 18 the the DET 6395w665357 8 19 basic basic ADJ 6395w665357 8 20 residues residue NOUN 6395w665357 8 21 arg59 arg59 SPACE 6395w665357 8 22 , , PUNCT 6395w665357 8 23 arg arg NOUN 6395w665357 8 24 61 61 NUM 6395w665357 8 25 and and CCONJ 6395w665357 8 26 his62 his62 PROPN 6395w665357 8 27 . . PUNCT 6395w665357 9 1 in in ADP 6395w665357 9 2 addition addition NOUN 6395w665357 9 3 , , PUNCT 6395w665357 9 4 we we PRON 6395w665357 9 5 have have AUX 6395w665357 9 6 helped help VERB 6395w665357 9 7 collaborators collaborator NOUN 6395w665357 9 8 to to PART 6395w665357 9 9 identify identify VERB 6395w665357 9 10 and and CCONJ 6395w665357 9 11 characterize characterize VERB 6395w665357 9 12 other other ADJ 6395w665357 9 13 selective selective ADJ 6395w665357 9 14 c1p c1p NOUN 6395w665357 9 15 binding binding ADJ 6395w665357 9 16 proteins protein NOUN 6395w665357 9 17 . . PUNCT 6395w665357 10 1 during during ADP 6395w665357 10 2 the the DET 6395w665357 10 3 course course NOUN 6395w665357 10 4 of of ADP 6395w665357 10 5 these these DET 6395w665357 10 6 studies study NOUN 6395w665357 10 7 , , PUNCT 6395w665357 10 8 we we PRON 6395w665357 10 9 found find VERB 6395w665357 10 10 that that SCONJ 6395w665357 10 11 cpla2α cpla2α ADP 6395w665357 10 12 ; ; PUNCT 6395w665357 10 13 is be AUX 6395w665357 10 14 also also ADV 6395w665357 10 15 capable capable ADJ 6395w665357 10 16 of of ADP 6395w665357 10 17 generating generate VERB 6395w665357 10 18 cellular cellular ADJ 6395w665357 10 19 vesicles vesicle NOUN 6395w665357 10 20 proposed propose VERB 6395w665357 10 21 to to PART 6395w665357 10 22 be be AUX 6395w665357 10 23 involved involve VERB 6395w665357 10 24 in in ADP 6395w665357 10 25 trafficking traffic VERB 6395w665357 10 26 cargo cargo NOUN 6395w665357 10 27 from from ADP 6395w665357 10 28 the the DET 6395w665357 10 29 golgi golgi NOUN 6395w665357 10 30 apparatus apparatus NOUN 6395w665357 10 31 to to ADP 6395w665357 10 32 the the DET 6395w665357 10 33 plasma plasma NOUN 6395w665357 10 34 membrane membrane NOUN 6395w665357 10 35 , , PUNCT 6395w665357 10 36 which which PRON 6395w665357 10 37 is be AUX 6395w665357 10 38 supported support VERB 6395w665357 10 39 by by ADP 6395w665357 10 40 several several ADJ 6395w665357 10 41 other other ADJ 6395w665357 10 42 reports report NOUN 6395w665357 10 43 in in ADP 6395w665357 10 44 the the DET 6395w665357 10 45 literature literature NOUN 6395w665357 10 46 . . PUNCT 6395w665357 11 1 seeing see VERB 6395w665357 11 2 that that SCONJ 6395w665357 11 3 the the DET 6395w665357 11 4 c2 c2 PROPN 6395w665357 11 5 domain domain NOUN 6395w665357 11 6 of of ADP 6395w665357 11 7 cpla2α cpla2α PROPN 6395w665357 11 8 ; ; PUNCT 6395w665357 11 9 was be AUX 6395w665357 11 10 only only ADV 6395w665357 11 11 one one NUM 6395w665357 11 12 of of ADP 6395w665357 11 13 three three NUM 6395w665357 11 14 c2 c2 PROPN 6395w665357 11 15 domains domain NOUN 6395w665357 11 16 shown show VERB 6395w665357 11 17 to to PART 6395w665357 11 18 bend bend VERB 6395w665357 11 19 membranes membrane NOUN 6395w665357 11 20 , , PUNCT 6395w665357 11 21 we we PRON 6395w665357 11 22 began begin VERB 6395w665357 11 23 a a DET 6395w665357 11 24 mechanistic mechanistic ADJ 6395w665357 11 25 study study NOUN 6395w665357 11 26 to to PART 6395w665357 11 27 better well ADV 6395w665357 11 28 understand understand VERB 6395w665357 11 29 c2 c2 PROPN 6395w665357 11 30 domain domain NOUN 6395w665357 11 31 - - PUNCT 6395w665357 11 32 dependent dependent ADJ 6395w665357 11 33 membrane membrane NOUN 6395w665357 11 34 bending bending NOUN 6395w665357 11 35 . . PUNCT 6395w665357 12 1 we we PRON 6395w665357 12 2 found find VERB 6395w665357 12 3 that that SCONJ 6395w665357 12 4 cpla2α cpla2α ADP 6395w665357 12 5 ; ; PUNCT 6395w665357 12 6 c2 c2 PROPN 6395w665357 12 7 domain domain NOUN 6395w665357 12 8 penetration penetration NOUN 6395w665357 12 9 into into ADP 6395w665357 12 10 the the DET 6395w665357 12 11 membrane membrane NOUN 6395w665357 12 12 is be AUX 6395w665357 12 13 a a DET 6395w665357 12 14 critical critical ADJ 6395w665357 12 15 component component NOUN 6395w665357 12 16 of of ADP 6395w665357 12 17 the the DET 6395w665357 12 18 protein protein NOUN 6395w665357 12 19 's 's PART 6395w665357 12 20 ability ability NOUN 6395w665357 12 21 to to PART 6395w665357 12 22 bend bend VERB 6395w665357 12 23 membranes membrane NOUN 6395w665357 12 24 in in ADP 6395w665357 12 25 vitro vitro X 6395w665357 12 26 . . PUNCT 6395w665357 13 1 our our PRON 6395w665357 13 2 recent recent ADJ 6395w665357 13 3 work work NOUN 6395w665357 13 4 delivered deliver VERB 6395w665357 13 5 evidence evidence NOUN 6395w665357 13 6 supporting support VERB 6395w665357 13 7 the the DET 6395w665357 13 8 formation formation NOUN 6395w665357 13 9 of of ADP 6395w665357 13 10 large large ADJ 6395w665357 13 11 protein protein NOUN 6395w665357 13 12 oligomers oligomer NOUN 6395w665357 13 13 through through ADP 6395w665357 13 14 the the DET 6395w665357 13 15 c2 c2 PROPN 6395w665357 13 16 domain domain NOUN 6395w665357 13 17 that that PRON 6395w665357 13 18 are be AUX 6395w665357 13 19 capable capable ADJ 6395w665357 13 20 of of ADP 6395w665357 13 21 sensing sense VERB 6395w665357 13 22 and and CCONJ 6395w665357 13 23 inducing induce VERB 6395w665357 13 24 membrane membrane NOUN 6395w665357 13 25 bending bend VERB 6395w665357 13 26 through through ADP 6395w665357 13 27 a a DET 6395w665357 13 28 novel novel ADJ 6395w665357 13 29 mechanism mechanism NOUN 6395w665357 13 30 for for ADP 6395w665357 13 31 c2 c2 PROPN 6395w665357 13 32 lipid lipid NOUN 6395w665357 13 33 binding bind VERB 6395w665357 13 34 domains domain NOUN 6395w665357 13 35 . . PUNCT 6395w665357 14 1 these these DET 6395w665357 14 2 experimental experimental ADJ 6395w665357 14 3 findings finding NOUN 6395w665357 14 4 have have AUX 6395w665357 14 5 already already ADV 6395w665357 14 6 been be AUX 6395w665357 14 7 utilized utilize VERB 6395w665357 14 8 to to PART 6395w665357 14 9 better well ADV 6395w665357 14 10 understand understand VERB 6395w665357 14 11 c1p c1p NOUN 6395w665357 14 12 binding bind VERB 6395w665357 14 13 and and CCONJ 6395w665357 14 14 have have AUX 6395w665357 14 15 improved improve VERB 6395w665357 14 16 our our PRON 6395w665357 14 17 understanding understanding NOUN 6395w665357 14 18 of of ADP 6395w665357 14 19 this this DET 6395w665357 14 20 tightly tightly ADV 6395w665357 14 21 regulated regulate VERB 6395w665357 14 22 protein protein NOUN 6395w665357 14 23 and and CCONJ 6395w665357 14 24 its its PRON 6395w665357 14 25 function function NOUN 6395w665357 14 26 in in ADP 6395w665357 14 27 vivo vivo PROPN 6395w665357 14 28 . . PUNCT 6395w665357 15 1 this this DET 6395w665357 15 2 work work NOUN 6395w665357 15 3 has have AUX 6395w665357 15 4 provided provide VERB 6395w665357 15 5 the the DET 6395w665357 15 6 groundwork groundwork NOUN 6395w665357 15 7 necessary necessary ADJ 6395w665357 15 8 to to PART 6395w665357 15 9 develop develop VERB 6395w665357 15 10 a a DET 6395w665357 15 11 selective selective NOUN 6395w665357 15 12 cpla2α cpla2α ADP 6395w665357 15 13 ; ; PUNCT 6395w665357 15 14 inhibitor inhibitor NOUN 6395w665357 15 15 that that PRON 6395w665357 15 16 is be AUX 6395w665357 15 17 capable capable ADJ 6395w665357 15 18 of of ADP 6395w665357 15 19 recognizing recognize VERB 6395w665357 15 20 cpla2α cpla2α ADP 6395w665357 15 21 ; ; PUNCT 6395w665357 15 22 over over ADP 6395w665357 15 23 other other ADJ 6395w665357 15 24 phospholipases phospholipase NOUN 6395w665357 15 25 by by ADP 6395w665357 15 26 targeting target VERB 6395w665357 15 27 the the DET 6395w665357 15 28 c1p c1p NOUN 6395w665357 15 29 binding bind VERB 6395w665357 15 30 site site NOUN 6395w665357 15 31 . . PUNCT 6395w665357 16 1 through through ADP 6395w665357 16 2 further further ADJ 6395w665357 16 3 analysis analysis NOUN 6395w665357 16 4 of of ADP 6395w665357 16 5 the the DET 6395w665357 16 6 particular particular ADJ 6395w665357 16 7 residues residue NOUN 6395w665357 16 8 responsible responsible ADJ 6395w665357 16 9 for for ADP 6395w665357 16 10 oligomerization oligomerization NOUN 6395w665357 16 11 , , PUNCT 6395w665357 16 12 cpla2α cpla2α ADP 6395w665357 16 13 ; ; PUNCT 6395w665357 16 14 could could AUX 6395w665357 16 15 maintain maintain VERB 6395w665357 16 16 its its PRON 6395w665357 16 17 homeostatic homeostatic ADJ 6395w665357 16 18 function function NOUN 6395w665357 16 19 in in ADP 6395w665357 16 20 vesicular vesicular ADJ 6395w665357 16 21 trafficking trafficking NOUN 6395w665357 16 22 after after ADP 6395w665357 16 23 treatment treatment NOUN 6395w665357 16 24 with with ADP 6395w665357 16 25 the the DET 6395w665357 16 26 therapeutic therapeutic NOUN 6395w665357 16 27 . . PUNCT 6395w665357 17 1 this this DET 6395w665357 17 2 knowledge knowledge NOUN 6395w665357 17 3 of of ADP 6395w665357 17 4 the the DET 6395w665357 17 5 enzyme enzyme NOUN 6395w665357 17 6 's 's PART 6395w665357 17 7 structure structure NOUN 6395w665357 17 8 and and CCONJ 6395w665357 17 9 function function NOUN 6395w665357 17 10 provide provide VERB 6395w665357 17 11 insight insight NOUN 6395w665357 17 12 to to PART 6395w665357 17 13 develop develop VERB 6395w665357 17 14 an an DET 6395w665357 17 15 optimal optimal ADJ 6395w665357 17 16 therapeutic therapeutic ADJ 6395w665357 17 17 inhibitor inhibitor NOUN 6395w665357 17 18 . . PUNCT 6395w665357 18 1 this this DET 6395w665357 18 2 model model NOUN 6395w665357 18 3 therapeutic therapeutic ADJ 6395w665357 18 4 would would AUX 6395w665357 18 5 retain retain VERB 6395w665357 18 6 membrane membrane NOUN 6395w665357 18 7 - - PUNCT 6395w665357 18 8 bending bend VERB 6395w665357 18 9 capabilities capability NOUN 6395w665357 18 10 while while SCONJ 6395w665357 18 11 decreasing decrease VERB 6395w665357 18 12 catalytic catalytic ADJ 6395w665357 18 13 activity activity NOUN 6395w665357 18 14 of of ADP 6395w665357 18 15 the the DET 6395w665357 18 16 enzyme enzyme NOUN 6395w665357 18 17 , , PUNCT 6395w665357 18 18 which which PRON 6395w665357 18 19 has have AUX 6395w665357 18 20 been be AUX 6395w665357 18 21 linked link VERB 6395w665357 18 22 to to ADP 6395w665357 18 23 pathological pathological ADJ 6395w665357 18 24 roles role NOUN 6395w665357 18 25 in in ADP 6395w665357 18 26 cancer cancer NOUN 6395w665357 18 27 , , PUNCT 6395w665357 18 28 asthma asthma NOUN 6395w665357 18 29 , , PUNCT 6395w665357 18 30 arthritis arthritis NOUN 6395w665357 18 31 and and CCONJ 6395w665357 18 32 heart heart NOUN 6395w665357 18 33 disease disease NOUN 6395w665357 18 34 . . PUNCT