id sid tid token lemma pos 6108v982n49 1 1 the the DET 6108v982n49 1 2 complex complex ADJ 6108v982n49 1 3 yet yet CCONJ 6108v982n49 1 4 interrelated interrelated ADJ 6108v982n49 1 5 connections connection NOUN 6108v982n49 1 6 between between ADP 6108v982n49 1 7 cancer cancer NOUN 6108v982n49 1 8 metabolism metabolism NOUN 6108v982n49 1 9 , , PUNCT 6108v982n49 1 10 gene gene NOUN 6108v982n49 1 11 expression expression NOUN 6108v982n49 1 12 , , PUNCT 6108v982n49 1 13 and and CCONJ 6108v982n49 1 14 oncogenic oncogenic ADJ 6108v982n49 1 15 driver driver NOUN 6108v982n49 1 16 genes gene NOUN 6108v982n49 1 17 have have VERB 6108v982n49 1 18 the the DET 6108v982n49 1 19 potential potential NOUN 6108v982n49 1 20 to to PART 6108v982n49 1 21 identify identify VERB 6108v982n49 1 22 novel novel ADJ 6108v982n49 1 23 biomarkers biomarker NOUN 6108v982n49 1 24 and and CCONJ 6108v982n49 1 25 drug drug NOUN 6108v982n49 1 26 targets target NOUN 6108v982n49 1 27 with with ADP 6108v982n49 1 28 prognostic prognostic ADJ 6108v982n49 1 29 and and CCONJ 6108v982n49 1 30 therapeutic therapeutic ADJ 6108v982n49 1 31 value value NOUN 6108v982n49 1 32 . . PUNCT 6108v982n49 2 1 in in ADP 6108v982n49 2 2 this this DET 6108v982n49 2 3 thesis thesis NOUN 6108v982n49 2 4 , , PUNCT 6108v982n49 2 5 i i PRON 6108v982n49 2 6 quantified quantify VERB 6108v982n49 2 7 and and CCONJ 6108v982n49 2 8 compared compare VERB 6108v982n49 2 9 the the DET 6108v982n49 2 10 levels level NOUN 6108v982n49 2 11 of of ADP 6108v982n49 2 12 374 374 NUM 6108v982n49 2 13 metabolites metabolite NOUN 6108v982n49 2 14 in in ADP 6108v982n49 2 15 breast breast NOUN 6108v982n49 2 16 tumor tumor NOUN 6108v982n49 2 17 tissue tissue NOUN 6108v982n49 2 18 from from ADP 6108v982n49 2 19 normal normal ADJ 6108v982n49 2 20 tissue tissue NOUN 6108v982n49 2 21 and and CCONJ 6108v982n49 2 22 transgenic transgenic NOUN 6108v982n49 2 23 mouse mouse NOUN 6108v982n49 2 24 breast breast NOUN 6108v982n49 2 25 cancer cancer NOUN 6108v982n49 2 26 models model NOUN 6108v982n49 2 27 overexpressing overexpresse VERB 6108v982n49 2 28 a a DET 6108v982n49 2 29 panel panel NOUN 6108v982n49 2 30 of of ADP 6108v982n49 2 31 oncogenes oncogene NOUN 6108v982n49 2 32 ( ( PUNCT 6108v982n49 2 33 pymt pymt X 6108v982n49 2 34 , , PUNCT 6108v982n49 2 35 pymt pymt PROPN 6108v982n49 2 36 - - PUNCT 6108v982n49 2 37 db db PROPN 6108v982n49 2 38 , , PUNCT 6108v982n49 2 39 wnt1 wnt1 PROPN 6108v982n49 2 40 , , PUNCT 6108v982n49 2 41 neu neu PROPN 6108v982n49 2 42 , , PUNCT 6108v982n49 2 43 and and CCONJ 6108v982n49 2 44 c3 c3 PROPN 6108v982n49 2 45 - - PUNCT 6108v982n49 2 46 tag tag NOUN 6108v982n49 2 47 ) ) PUNCT 6108v982n49 2 48 . . PUNCT 6108v982n49 3 1 i i PRON 6108v982n49 3 2 identified identify VERB 6108v982n49 3 3 oncogene oncogene NOUN 6108v982n49 3 4 - - PUNCT 6108v982n49 3 5 specific specific ADJ 6108v982n49 3 6 metabolic metabolic NOUN 6108v982n49 3 7 profiles profile NOUN 6108v982n49 3 8 and and CCONJ 6108v982n49 3 9 used use VERB 6108v982n49 3 10 these these DET 6108v982n49 3 11 model model NOUN 6108v982n49 3 12 - - PUNCT 6108v982n49 3 13 specific specific ADJ 6108v982n49 3 14 metabolites metabolite NOUN 6108v982n49 3 15 to to PART 6108v982n49 3 16 predict predict VERB 6108v982n49 3 17 patient patient ADJ 6108v982n49 3 18 survival survival NOUN 6108v982n49 3 19 . . PUNCT 6108v982n49 4 1 except except SCONJ 6108v982n49 4 2 for for ADP 6108v982n49 4 3 c3 c3 PROPN 6108v982n49 4 4 - - PUNCT 6108v982n49 4 5 tag tag NOUN 6108v982n49 4 6 - - PUNCT 6108v982n49 4 7 specific specific ADJ 6108v982n49 4 8 metabolites metabolite NOUN 6108v982n49 4 9 , , PUNCT 6108v982n49 4 10 the the DET 6108v982n49 4 11 model model NOUN 6108v982n49 4 12 - - PUNCT 6108v982n49 4 13 specific specific ADJ 6108v982n49 4 14 metabolites metabolite NOUN 6108v982n49 4 15 were be AUX 6108v982n49 4 16 unable unable ADJ 6108v982n49 4 17 to to PART 6108v982n49 4 18 predict predict VERB 6108v982n49 4 19 survival survival NOUN 6108v982n49 4 20 in in ADP 6108v982n49 4 21 breast breast NOUN 6108v982n49 4 22 cancer cancer NOUN 6108v982n49 4 23 patients.to patients.to X 6108v982n49 4 24 further far ADV 6108v982n49 4 25 identify identify VERB 6108v982n49 4 26 the the DET 6108v982n49 4 27 critical critical ADJ 6108v982n49 4 28 metabolic metabolic NOUN 6108v982n49 4 29 players player NOUN 6108v982n49 4 30 in in ADP 6108v982n49 4 31 breast breast NOUN 6108v982n49 4 32 cancer cancer NOUN 6108v982n49 4 33 , , PUNCT 6108v982n49 4 34 we we PRON 6108v982n49 4 35 developed develop VERB 6108v982n49 4 36 a a DET 6108v982n49 4 37 correlation correlation NOUN 6108v982n49 4 38 - - PUNCT 6108v982n49 4 39 based base VERB 6108v982n49 4 40 network network NOUN 6108v982n49 4 41 analysis analysis NOUN 6108v982n49 4 42 that that PRON 6108v982n49 4 43 captures capture VERB 6108v982n49 4 44 the the DET 6108v982n49 4 45 interactions interaction NOUN 6108v982n49 4 46 between between ADP 6108v982n49 4 47 metabolic metabolic NOUN 6108v982n49 4 48 profiling profiling NOUN 6108v982n49 4 49 and and CCONJ 6108v982n49 4 50 gene gene NOUN 6108v982n49 4 51 expression expression NOUN 6108v982n49 4 52 data datum NOUN 6108v982n49 4 53 . . PUNCT 6108v982n49 5 1 our our PRON 6108v982n49 5 2 network network NOUN 6108v982n49 5 3 analysis analysis NOUN 6108v982n49 5 4 identified identify VERB 6108v982n49 5 5 35 35 NUM 6108v982n49 5 6 metabolite metabolite NOUN 6108v982n49 5 7 and and CCONJ 6108v982n49 5 8 33 33 NUM 6108v982n49 5 9 gene gene NOUN 6108v982n49 5 10 hubs hub NOUN 6108v982n49 5 11 that that PRON 6108v982n49 5 12 had have VERB 6108v982n49 5 13 the the DET 6108v982n49 5 14 most most ADJ 6108v982n49 5 15 network network NOUN 6108v982n49 5 16 correlations correlation NOUN 6108v982n49 5 17 . . PUNCT 6108v982n49 6 1 these these DET 6108v982n49 6 2 hubs hub NOUN 6108v982n49 6 3 have have VERB 6108v982n49 6 4 prognostic prognostic ADJ 6108v982n49 6 5 value value NOUN 6108v982n49 6 6 and and CCONJ 6108v982n49 6 7 are be AUX 6108v982n49 6 8 likely likely ADV 6108v982n49 6 9 integral integral ADJ 6108v982n49 6 10 to to ADP 6108v982n49 6 11 tumor tumor NOUN 6108v982n49 6 12 metabolism metabolism NOUN 6108v982n49 6 13 and and CCONJ 6108v982n49 6 14 breast breast NOUN 6108v982n49 6 15 cancer cancer NOUN 6108v982n49 6 16 . . PUNCT 6108v982n49 7 1 i i PRON 6108v982n49 7 2 then then ADV 6108v982n49 7 3 focused focus VERB 6108v982n49 7 4 on on ADP 6108v982n49 7 5 the the DET 6108v982n49 7 6 gene gene NOUN 6108v982n49 7 7 hub hub NOUN 6108v982n49 7 8 aquaporin-7 aquaporin-7 ADP 6108v982n49 7 9 ( ( PUNCT 6108v982n49 7 10 aqp7 aqp7 PROPN 6108v982n49 7 11 ) ) PUNCT 6108v982n49 7 12 , , PUNCT 6108v982n49 7 13 a a DET 6108v982n49 7 14 water water NOUN 6108v982n49 7 15 and and CCONJ 6108v982n49 7 16 glycerol glycerol NOUN 6108v982n49 7 17 channel channel NOUN 6108v982n49 7 18 protein protein NOUN 6108v982n49 7 19 , , PUNCT 6108v982n49 7 20 as as ADP 6108v982n49 7 21 a a DET 6108v982n49 7 22 novel novel ADJ 6108v982n49 7 23 regulator regulator NOUN 6108v982n49 7 24 of of ADP 6108v982n49 7 25 breast breast NOUN 6108v982n49 7 26 cancer cancer NOUN 6108v982n49 7 27 . . PUNCT 6108v982n49 8 1 aqp7 aqp7 PROPN 6108v982n49 8 2 deficiency deficiency NOUN 6108v982n49 8 3 in in ADP 6108v982n49 8 4 animal animal NOUN 6108v982n49 8 5 models model NOUN 6108v982n49 8 6 is be AUX 6108v982n49 8 7 associated associate VERB 6108v982n49 8 8 with with ADP 6108v982n49 8 9 adipocyte adipocyte NOUN 6108v982n49 8 10 hypertrophy hypertrophy NOUN 6108v982n49 8 11 , , PUNCT 6108v982n49 8 12 increased increase VERB 6108v982n49 8 13 glycerol glycerol NOUN 6108v982n49 8 14 and and CCONJ 6108v982n49 8 15 triglyceride triglyceride NOUN 6108v982n49 8 16 accumulation accumulation NOUN 6108v982n49 8 17 , , PUNCT 6108v982n49 8 18 insulin insulin NOUN 6108v982n49 8 19 resistance resistance NOUN 6108v982n49 8 20 , , PUNCT 6108v982n49 8 21 and and CCONJ 6108v982n49 8 22 obesity obesity NOUN 6108v982n49 8 23 . . PUNCT 6108v982n49 9 1 i i PRON 6108v982n49 9 2 discovered discover VERB 6108v982n49 9 3 that that SCONJ 6108v982n49 9 4 aqp7 aqp7 PROPN 6108v982n49 9 5 is be AUX 6108v982n49 9 6 a a DET 6108v982n49 9 7 prognostic prognostic ADJ 6108v982n49 9 8 marker marker NOUN 6108v982n49 9 9 of of ADP 6108v982n49 9 10 overall overall ADJ 6108v982n49 9 11 survival survival NOUN 6108v982n49 9 12 and and CCONJ 6108v982n49 9 13 metastasis metastasis NOUN 6108v982n49 9 14 in in ADP 6108v982n49 9 15 breast breast NOUN 6108v982n49 9 16 cancer cancer NOUN 6108v982n49 9 17 patients patient NOUN 6108v982n49 9 18 . . PUNCT 6108v982n49 10 1 aqp7 aqp7 PROPN 6108v982n49 10 2 is be AUX 6108v982n49 10 3 expressed express VERB 6108v982n49 10 4 in in ADP 6108v982n49 10 5 the the DET 6108v982n49 10 6 epithelium epithelium NOUN 6108v982n49 10 7 and and CCONJ 6108v982n49 10 8 adipocytes adipocyte NOUN 6108v982n49 10 9 in in ADP 6108v982n49 10 10 normal normal ADJ 6108v982n49 10 11 and and CCONJ 6108v982n49 10 12 tumor tumor NOUN 6108v982n49 10 13 breast breast NOUN 6108v982n49 10 14 tissue tissue NOUN 6108v982n49 10 15 . . PUNCT 6108v982n49 11 1 reduced reduce VERB 6108v982n49 11 2 aqp7 aqp7 PROPN 6108v982n49 11 3 expression expression NOUN 6108v982n49 11 4 in in ADP 6108v982n49 11 5 mouse mouse NOUN 6108v982n49 11 6 breast breast NOUN 6108v982n49 11 7 cancer cancer NOUN 6108v982n49 11 8 models model NOUN 6108v982n49 11 9 leads lead VERB 6108v982n49 11 10 to to ADP 6108v982n49 11 11 reduced reduce VERB 6108v982n49 11 12 primary primary ADJ 6108v982n49 11 13 tumor tumor NOUN 6108v982n49 11 14 burden burden NOUN 6108v982n49 11 15 and and CCONJ 6108v982n49 11 16 lung lung NOUN 6108v982n49 11 17 metastasis metastasis NOUN 6108v982n49 11 18 . . PUNCT 6108v982n49 12 1 these these DET 6108v982n49 12 2 data datum NOUN 6108v982n49 12 3 suggest suggest VERB 6108v982n49 12 4 aqp7 aqp7 PROPN 6108v982n49 12 5 as as ADP 6108v982n49 12 6 a a DET 6108v982n49 12 7 target target NOUN 6108v982n49 12 8 of of ADP 6108v982n49 12 9 breast breast NOUN 6108v982n49 12 10 cancer cancer NOUN 6108v982n49 12 11 treatment treatment NOUN 6108v982n49 12 12 . . PUNCT 6108v982n49 13 1 further further ADJ 6108v982n49 13 2 metabolomics metabolomic NOUN 6108v982n49 13 3 and and CCONJ 6108v982n49 13 4 complex complex ADJ 6108v982n49 13 5 lipid lipid NOUN 6108v982n49 13 6 profiling profiling NOUN 6108v982n49 13 7 of of ADP 6108v982n49 13 8 the the DET 6108v982n49 13 9 cells cell NOUN 6108v982n49 13 10 and and CCONJ 6108v982n49 13 11 tumors tumor NOUN 6108v982n49 13 12 revealed reveal VERB 6108v982n49 13 13 dramatically dramatically ADV 6108v982n49 13 14 altered alter VERB 6108v982n49 13 15 amino amino ADJ 6108v982n49 13 16 acid acid NOUN 6108v982n49 13 17 , , PUNCT 6108v982n49 13 18 carbohydrate carbohydrate NOUN 6108v982n49 13 19 , , PUNCT 6108v982n49 13 20 nucleotide nucleotide NOUN 6108v982n49 13 21 , , PUNCT 6108v982n49 13 22 and and CCONJ 6108v982n49 13 23 lipid lipid NOUN 6108v982n49 13 24 metabolism metabolism NOUN 6108v982n49 13 25 , , PUNCT 6108v982n49 13 26 including include VERB 6108v982n49 13 27 lowered lower VERB 6108v982n49 13 28 glutathione glutathione NOUN 6108v982n49 13 29 levels level NOUN 6108v982n49 13 30 and and CCONJ 6108v982n49 13 31 increased increase VERB 6108v982n49 13 32 lipid lipid NOUN 6108v982n49 13 33 levels level NOUN 6108v982n49 13 34 in in ADP 6108v982n49 13 35 aqp7 aqp7 PROPN 6108v982n49 13 36 knockdown knockdown NOUN 6108v982n49 13 37 cells cell NOUN 6108v982n49 13 38 and and CCONJ 6108v982n49 13 39 tumors tumor NOUN 6108v982n49 13 40 compared compare VERB 6108v982n49 13 41 to to ADP 6108v982n49 13 42 scrambled scramble VERB 6108v982n49 13 43 control control NOUN 6108v982n49 13 44 . . PUNCT 6108v982n49 14 1 using use VERB 6108v982n49 14 2 cell cell NOUN 6108v982n49 14 3 - - PUNCT 6108v982n49 14 4 based base VERB 6108v982n49 14 5 assays assay NOUN 6108v982n49 14 6 , , PUNCT 6108v982n49 14 7 we we PRON 6108v982n49 14 8 confirmed confirm VERB 6108v982n49 14 9 that that SCONJ 6108v982n49 14 10 aqp7 aqp7 PROPN 6108v982n49 14 11 knockdown knockdown NOUN 6108v982n49 14 12 decreased decrease VERB 6108v982n49 14 13 the the DET 6108v982n49 14 14 oxidative oxidative ADJ 6108v982n49 14 15 stress stress NOUN 6108v982n49 14 16 tolerance tolerance NOUN 6108v982n49 14 17 of of ADP 6108v982n49 14 18 cancer cancer NOUN 6108v982n49 14 19 cells cell NOUN 6108v982n49 14 20 , , PUNCT 6108v982n49 14 21 and and CCONJ 6108v982n49 14 22 altered alter VERB 6108v982n49 14 23 the the DET 6108v982n49 14 24 usage usage NOUN 6108v982n49 14 25 of of ADP 6108v982n49 14 26 arginine.using arginine.use VERB 6108v982n49 14 27 an an DET 6108v982n49 14 28 unbiased unbiased ADJ 6108v982n49 14 29 , , PUNCT 6108v982n49 14 30 discovery discovery NOUN 6108v982n49 14 31 - - PUNCT 6108v982n49 14 32 based base VERB 6108v982n49 14 33 approach approach NOUN 6108v982n49 14 34 , , PUNCT 6108v982n49 14 35 this this DET 6108v982n49 14 36 study study NOUN 6108v982n49 14 37 shed shed VERB 6108v982n49 14 38 light light NOUN 6108v982n49 14 39 on on ADP 6108v982n49 14 40 important important ADJ 6108v982n49 14 41 players player NOUN 6108v982n49 14 42 in in ADP 6108v982n49 14 43 breast breast NOUN 6108v982n49 14 44 cancer cancer NOUN 6108v982n49 14 45 metabolism metabolism NOUN 6108v982n49 14 46 from from ADP 6108v982n49 14 47 a a DET 6108v982n49 14 48 new new ADJ 6108v982n49 14 49 perspective perspective NOUN 6108v982n49 14 50 that that PRON 6108v982n49 14 51 complements complement VERB 6108v982n49 14 52 current current ADJ 6108v982n49 14 53 guided guide VERB 6108v982n49 14 54 network network NOUN 6108v982n49 14 55 analyses analysis NOUN 6108v982n49 14 56 . . PUNCT