id	sid	tid	token	lemma	pos
5x21td98j1p	1	1	with	with	ADP
5x21td98j1p	1	2	the	the	DET
5x21td98j1p	1	3	increasing	increase	VERB
5x21td98j1p	1	4	strength	strength	NOUN
5x21td98j1p	1	5	of	of	ADP
5x21td98j1p	1	6	computational	computational	ADJ
5x21td98j1p	1	7	resources	resource	NOUN
5x21td98j1p	1	8	,	,	PUNCT
5x21td98j1p	1	9	computational	computational	ADJ
5x21td98j1p	1	10	drug	drug	NOUN
5x21td98j1p	1	11	design	design	NOUN
5x21td98j1p	1	12	methodologies	methodology	NOUN
5x21td98j1p	1	13	have	have	AUX
5x21td98j1p	1	14	been	be	AUX
5x21td98j1p	1	15	used	use	VERB
5x21td98j1p	1	16	as	as	ADP
5x21td98j1p	1	17	tools	tool	NOUN
5x21td98j1p	1	18	in	in	ADP
5x21td98j1p	1	19	the	the	DET
5x21td98j1p	1	20	identification	identification	NOUN
5x21td98j1p	1	21	of	of	ADP
5x21td98j1p	1	22	lead	lead	ADJ
5x21td98j1p	1	23	molecules	molecule	NOUN
5x21td98j1p	1	24	for	for	ADP
5x21td98j1p	1	25	drug	drug	NOUN
5x21td98j1p	1	26	targets	target	NOUN
5x21td98j1p	1	27	.	.	PUNCT
5x21td98j1p	2	1	in	in	ADP
5x21td98j1p	2	2	my	my	PRON
5x21td98j1p	2	3	thesis	thesis	NOUN
5x21td98j1p	2	4	,	,	PUNCT
5x21td98j1p	2	5	i	i	PRON
5x21td98j1p	2	6	have	have	AUX
5x21td98j1p	2	7	utilized	utilize	VERB
5x21td98j1p	2	8	structure	structure	NOUN
5x21td98j1p	2	9	-	-	PUNCT
5x21td98j1p	2	10	based	base	VERB
5x21td98j1p	2	11	drug	drug	NOUN
5x21td98j1p	2	12	design	design	NOUN
5x21td98j1p	2	13	methodology	methodology	NOUN
5x21td98j1p	2	14	to	to	PART
5x21td98j1p	2	15	elucidate	elucidate	VERB
5x21td98j1p	2	16	information	information	NOUN
5x21td98j1p	2	17	targeting	target	VERB
5x21td98j1p	2	18	the	the	DET
5x21td98j1p	2	19	mammalian	mammalian	ADJ
5x21td98j1p	2	20	transcription	transcription	NOUN
5x21td98j1p	2	21	factor	factor	NOUN
5x21td98j1p	2	22	family	family	NOUN
5x21td98j1p	2	23	of	of	ADP
5x21td98j1p	2	24	notch	notch	NOUN
5x21td98j1p	2	25	.	.	PUNCT
5x21td98j1p	3	1	as	as	SCONJ
5x21td98j1p	3	2	a	a	DET
5x21td98j1p	3	3	crystal	crystal	NOUN
5x21td98j1p	3	4	structure	structure	NOUN
5x21td98j1p	3	5	solely	solely	ADV
5x21td98j1p	3	6	exists	exist	VERB
5x21td98j1p	3	7	for	for	ADP
5x21td98j1p	3	8	the	the	DET
5x21td98j1p	3	9	mammalian	mammalian	ADJ
5x21td98j1p	3	10	notch1	notch1	PROPN
5x21td98j1p	3	11	transactivation	transactivation	NOUN
5x21td98j1p	3	12	factor	factor	NOUN
5x21td98j1p	3	13	complex	complex	NOUN
5x21td98j1p	3	14	(	(	PUNCT
5x21td98j1p	3	15	pdb	pdb	NOUN
5x21td98j1p	3	16	:	:	PUNCT
5x21td98j1p	3	17	2f8x	2f8x	NOUN
5x21td98j1p	3	18	,	,	PUNCT
5x21td98j1p	3	19	resolution	resolution	NOUN
5x21td98j1p	3	20	:	:	PUNCT
5x21td98j1p	3	21	3.25ìä	3.25ìä	NUM
5x21td98j1p	3	22	'	'	PART
5x21td98j1p	3	23	_	_	X
5x21td98j1p	3	24	)	)	PUNCT
5x21td98j1p	3	25	,	,	PUNCT
5x21td98j1p	3	26	i	i	PRON
5x21td98j1p	3	27	initially	initially	ADV
5x21td98j1p	3	28	created	create	VERB
5x21td98j1p	3	29	homology	homology	NOUN
5x21td98j1p	3	30	models	model	NOUN
5x21td98j1p	3	31	for	for	ADP
5x21td98j1p	3	32	the	the	DET
5x21td98j1p	3	33	notch2	notch2	PROPN
5x21td98j1p	3	34	-	-	PUNCT
5x21td98j1p	3	35	notch4	notch4	NOUN
5x21td98j1p	3	36	transcription	transcription	NOUN
5x21td98j1p	3	37	factor	factor	NOUN
5x21td98j1p	3	38	complexes	complex	NOUN
5x21td98j1p	3	39	based	base	VERB
5x21td98j1p	3	40	on	on	ADP
5x21td98j1p	3	41	the	the	DET
5x21td98j1p	3	42	three	three	NUM
5x21td98j1p	3	43	-	-	PUNCT
5x21td98j1p	3	44	dimensional	dimensional	ADJ
5x21td98j1p	3	45	coordinates	coordinate	NOUN
5x21td98j1p	3	46	for	for	ADP
5x21td98j1p	3	47	each	each	DET
5x21td98j1p	3	48	atom	atom	NOUN
5x21td98j1p	3	49	of	of	ADP
5x21td98j1p	3	50	the	the	DET
5x21td98j1p	3	51	crystal	crystal	NOUN
5x21td98j1p	3	52	structure	structure	NOUN
5x21td98j1p	3	53	of	of	ADP
5x21td98j1p	3	54	notch1	notch1	PROPN
5x21td98j1p	3	55	.	.	PROPN
5x21td98j1p	3	56	of	of	ADP
5x21td98j1p	3	57	interest	interest	NOUN
5x21td98j1p	3	58	to	to	ADP
5x21td98j1p	3	59	our	our	PRON
5x21td98j1p	3	60	collaborators	collaborator	NOUN
5x21td98j1p	3	61	at	at	ADP
5x21td98j1p	3	62	the	the	DET
5x21td98j1p	3	63	dana	dana	PROPN
5x21td98j1p	3	64	-	-	PUNCT
5x21td98j1p	3	65	farber	farber	PROPN
5x21td98j1p	3	66	cancer	cancer	PROPN
5x21td98j1p	3	67	institute	institute	PROPN
5x21td98j1p	3	68	,	,	PUNCT
5x21td98j1p	3	69	a	a	DET
5x21td98j1p	3	70	mutant	mutant	NOUN
5x21td98j1p	3	71	of	of	ADP
5x21td98j1p	3	72	the	the	DET
5x21td98j1p	3	73	notch3	notch3	ADJ
5x21td98j1p	3	74	complex	complex	NOUN
5x21td98j1p	3	75	was	be	AUX
5x21td98j1p	3	76	tested	test	VERB
5x21td98j1p	3	77	to	to	PART
5x21td98j1p	3	78	address	address	VERB
5x21td98j1p	3	79	a	a	DET
5x21td98j1p	3	80	clinical	clinical	ADJ
5x21td98j1p	3	81	phenotype	phenotype	NOUN
5x21td98j1p	3	82	seen	see	VERB
5x21td98j1p	3	83	.	.	PUNCT
5x21td98j1p	4	1	also	also	ADV
5x21td98j1p	4	2	,	,	PUNCT
5x21td98j1p	4	3	weak	weak	ADJ
5x21td98j1p	4	4	protein	protein	NOUN
5x21td98j1p	4	5	-	-	PUNCT
5x21td98j1p	4	6	protein	protein	NOUN
5x21td98j1p	4	7	interactions	interaction	NOUN
5x21td98j1p	4	8	in	in	ADP
5x21td98j1p	4	9	the	the	DET
5x21td98j1p	4	10	notch1	notch1	PROPN
5x21td98j1p	4	11	interface	interface	NOUN
5x21td98j1p	4	12	were	be	AUX
5x21td98j1p	4	13	found	find	VERB
5x21td98j1p	4	14	to	to	PART
5x21td98j1p	4	15	allow	allow	VERB
5x21td98j1p	4	16	for	for	ADP
5x21td98j1p	4	17	the	the	DET
5x21td98j1p	4	18	dissociation	dissociation	NOUN
5x21td98j1p	4	19	of	of	ADP
5x21td98j1p	4	20	ank	ank	PROPN
5x21td98j1p	4	21	and	and	CCONJ
5x21td98j1p	4	22	csl	csl	PROPN
5x21td98j1p	4	23	once	once	ADV
5x21td98j1p	4	24	maml1	maml1	NOUN
5x21td98j1p	4	25	is	be	AUX
5x21td98j1p	4	26	removed	remove	VERB
5x21td98j1p	4	27	from	from	ADP
5x21td98j1p	4	28	the	the	DET
5x21td98j1p	4	29	complex	complex	NOUN
5x21td98j1p	4	30	.	.	PUNCT
5x21td98j1p	5	1	stapled	staple	VERB
5x21td98j1p	5	2	sahm	sahm	NOUN
5x21td98j1p	5	3	peptide	peptide	NOUN
5x21td98j1p	5	4	analogs	analog	NOUN
5x21td98j1p	5	5	were	be	AUX
5x21td98j1p	5	6	designed	design	VERB
5x21td98j1p	5	7	to	to	PART
5x21td98j1p	5	8	disrupt	disrupt	VERB
5x21td98j1p	5	9	the	the	DET
5x21td98j1p	5	10	protein	protein	NOUN
5x21td98j1p	5	11	-	-	PUNCT
5x21td98j1p	5	12	protein	protein	NOUN
5x21td98j1p	5	13	interactions	interaction	NOUN
5x21td98j1p	5	14	of	of	ADP
5x21td98j1p	5	15	the	the	DET
5x21td98j1p	5	16	notch1	notch1	PROPN
5x21td98j1p	5	17	-	-	PUNCT
5x21td98j1p	5	18	notch4	notch4	ADJ
5x21td98j1p	5	19	transactivation	transactivation	NOUN
5x21td98j1p	5	20	complexes	complex	NOUN
5x21td98j1p	5	21	,	,	PUNCT
5x21td98j1p	5	22	the	the	DET
5x21td98j1p	5	23	loss	loss	NOUN
5x21td98j1p	5	24	-	-	PUNCT
5x21td98j1p	5	25	of	of	ADP
5x21td98j1p	5	26	-	-	PUNCT
5x21td98j1p	5	27	function	function	NOUN
5x21td98j1p	5	28	or	or	CCONJ
5x21td98j1p	5	29	gain	gain	VERB
5x21td98j1p	5	30	-	-	PUNCT
5x21td98j1p	5	31	of	of	ADP
5x21td98j1p	5	32	-	-	PUNCT
5x21td98j1p	5	33	function	function	NOUN
5x21td98j1p	5	34	mutations	mutation	NOUN
5x21td98j1p	5	35	of	of	ADP
5x21td98j1p	5	36	which	which	PRON
5x21td98j1p	5	37	are	be	AUX
5x21td98j1p	5	38	related	relate	VERB
5x21td98j1p	5	39	to	to	ADP
5x21td98j1p	5	40	numerous	numerous	ADJ
5x21td98j1p	5	41	diseased	diseased	ADJ
5x21td98j1p	5	42	states	state	NOUN
5x21td98j1p	5	43	,	,	PUNCT
5x21td98j1p	5	44	including	include	VERB
5x21td98j1p	5	45	cancers	cancer	NOUN
5x21td98j1p	5	46	.	.	PUNCT
5x21td98j1p	6	1	stapled	staple	VERB
5x21td98j1p	6	2	sahm	sahm	NOUN
5x21td98j1p	6	3	mutants	mutant	NOUN
5x21td98j1p	6	4	disrupting	disrupt	VERB
5x21td98j1p	6	5	analogous	analogous	ADJ
5x21td98j1p	6	6	regions	region	NOUN
5x21td98j1p	6	7	of	of	ADP
5x21td98j1p	6	8	interface	interface	NOUN
5x21td98j1p	6	9	homologs	homolog	NOUN
5x21td98j1p	6	10	resulted	result	VERB
5x21td98j1p	6	11	in	in	ADP
5x21td98j1p	6	12	quick	quick	ADJ
5x21td98j1p	6	13	molecular	molecular	ADJ
5x21td98j1p	6	14	dynamics	dynamic	NOUN
5x21td98j1p	6	15	convergence	convergence	NOUN
5x21td98j1p	6	16	.	.	PUNCT
5x21td98j1p	7	1	stapled	stapled	ADJ
5x21td98j1p	7	2	sahm	sahm	NOUN
5x21td98j1p	7	3	mutants	mutant	NOUN
5x21td98j1p	7	4	were	be	AUX
5x21td98j1p	7	5	designed	design	VERB
5x21td98j1p	7	6	by	by	ADP
5x21td98j1p	7	7	natural	natural	ADJ
5x21td98j1p	7	8	amino	amino	NOUN
5x21td98j1p	7	9	acid	acid	NOUN
5x21td98j1p	7	10	point	point	NOUN
5x21td98j1p	7	11	mutations	mutation	NOUN
5x21td98j1p	7	12	to	to	PART
5x21td98j1p	7	13	allow	allow	VERB
5x21td98j1p	7	14	for	for	ADP
5x21td98j1p	7	15	higher	high	ADJ
5x21td98j1p	7	16	binding	binding	ADJ
5x21td98j1p	7	17	affinity	affinity	NOUN
5x21td98j1p	7	18	to	to	ADP
5x21td98j1p	7	19	non	non	ADJ
5x21td98j1p	7	20	-	-	ADJ
5x21td98j1p	7	21	analogous	analogous	ADJ
5x21td98j1p	7	22	ank	ank	NOUN
5x21td98j1p	7	23	/	/	SYM
5x21td98j1p	7	24	csl	csl	PROPN
5x21td98j1p	7	25	interfaces	interface	NOUN
5x21td98j1p	7	26	.	.	PUNCT
5x21td98j1p	8	1	novel	novel	ADJ
5x21td98j1p	8	2	sahm1	sahm1	PROPN
5x21td98j1p	8	3	peptide	peptide	NOUN
5x21td98j1p	8	4	antagonists	antagonist	NOUN
5x21td98j1p	8	5	were	be	AUX
5x21td98j1p	8	6	developed	develop	VERB
5x21td98j1p	8	7	through	through	ADP
5x21td98j1p	8	8	varying	vary	VERB
5x21td98j1p	8	9	the	the	DET
5x21td98j1p	8	10	location	location	NOUN
5x21td98j1p	8	11	of	of	ADP
5x21td98j1p	8	12	the	the	DET
5x21td98j1p	8	13	staple	staple	NOUN
5x21td98j1p	8	14	and	and	CCONJ
5x21td98j1p	8	15	docking	docking	NOUN
5x21td98j1p	8	16	to	to	ADP
5x21td98j1p	8	17	the	the	DET
5x21td98j1p	8	18	notch1	notch1	PROPN
5x21td98j1p	8	19	interface	interface	NOUN
5x21td98j1p	8	20	;	;	PUNCT
5x21td98j1p	8	21	one	one	NUM
5x21td98j1p	8	22	stapled	staple	VERB
5x21td98j1p	8	23	peptide	peptide	NOUN
5x21td98j1p	8	24	shows	show	VERB
5x21td98j1p	8	25	quick	quick	ADJ
5x21td98j1p	8	26	md	md	PROPN
5x21td98j1p	8	27	convergence	convergence	NOUN
5x21td98j1p	8	28	,	,	PUNCT
5x21td98j1p	8	29	analogous	analogous	ADJ
5x21td98j1p	8	30	to	to	ADP
5x21td98j1p	8	31	that	that	PRON
5x21td98j1p	8	32	of	of	ADP
5x21td98j1p	8	33	sahm1	sahm1	PROPN
5x21td98j1p	8	34	.	.	PUNCT
5x21td98j1p	9	1	the	the	DET
5x21td98j1p	9	2	notch2	notch2	PROPN
5x21td98j1p	9	3	-	-	PUNCT
5x21td98j1p	9	4	notch4	notch4	ADJ
5x21td98j1p	9	5	ank	ank	NOUN
5x21td98j1p	9	6	/	/	SYM
5x21td98j1p	9	7	csl	csl	PROPN
5x21td98j1p	9	8	interfaces	interface	NOUN
5x21td98j1p	9	9	were	be	AUX
5x21td98j1p	9	10	also	also	ADV
5x21td98j1p	9	11	targeted	target	VERB
5x21td98j1p	9	12	at	at	ADP
5x21td98j1p	9	13	two	two	NUM
5x21td98j1p	9	14	hot	hot	ADJ
5x21td98j1p	9	15	-	-	PUNCT
5x21td98j1p	9	16	spot	spot	NOUN
5x21td98j1p	9	17	regions	region	NOUN
5x21td98j1p	9	18	by	by	ADP
5x21td98j1p	9	19	small	small	ADJ
5x21td98j1p	9	20	molecule	molecule	NOUN
5x21td98j1p	9	21	ligands	ligand	NOUN
5x21td98j1p	9	22	,	,	PUNCT
5x21td98j1p	9	23	which	which	PRON
5x21td98j1p	9	24	will	will	AUX
5x21td98j1p	9	25	be	be	AUX
5x21td98j1p	9	26	subsequently	subsequently	ADV
5x21td98j1p	9	27	tested	test	VERB
5x21td98j1p	9	28	computationally	computationally	ADV
5x21td98j1p	9	29	by	by	ADP
5x21td98j1p	9	30	mm	mm	NOUN
5x21td98j1p	9	31	/	/	SYM
5x21td98j1p	9	32	pbsa	pbsa	NOUN
5x21td98j1p	9	33	rescoring	rescore	VERB
5x21td98j1p	9	34	and	and	CCONJ
5x21td98j1p	9	35	validated	validate	VERB
5x21td98j1p	9	36	by	by	ADP
5x21td98j1p	9	37	experimental	experimental	ADJ
5x21td98j1p	9	38	measures	measure	NOUN
5x21td98j1p	9	39	by	by	ADP
5x21td98j1p	9	40	our	our	PRON
5x21td98j1p	9	41	collaborators	collaborator	NOUN
5x21td98j1p	9	42	.	.	PUNCT
5x21td98j1p	10	1	the	the	DET
5x21td98j1p	10	2	quick	quick	ADJ
5x21td98j1p	10	3	and	and	CCONJ
5x21td98j1p	10	4	cost	cost	NOUN
5x21td98j1p	10	5	-	-	PUNCT
5x21td98j1p	10	6	efficient	efficient	ADJ
5x21td98j1p	10	7	computational	computational	ADJ
5x21td98j1p	10	8	techniques	technique	NOUN
5x21td98j1p	10	9	that	that	PRON
5x21td98j1p	10	10	help	help	VERB
5x21td98j1p	10	11	elucidate	elucidate	VERB
5x21td98j1p	10	12	the	the	DET
5x21td98j1p	10	13	mechanisms	mechanism	NOUN
5x21td98j1p	10	14	associated	associate	VERB
5x21td98j1p	10	15	with	with	ADP
5x21td98j1p	10	16	binding	bind	VERB
5x21td98j1p	10	17	and	and	CCONJ
5x21td98j1p	10	18	have	have	AUX
5x21td98j1p	10	19	been	be	AUX
5x21td98j1p	10	20	applied	apply	VERB
5x21td98j1p	10	21	include	include	VERB
5x21td98j1p	10	22	:	:	PUNCT
5x21td98j1p	10	23	homology	homology	NOUN
5x21td98j1p	10	24	modeling	modeling	NOUN
5x21td98j1p	10	25	,	,	PUNCT
5x21td98j1p	10	26	equilibration	equilibration	NOUN
5x21td98j1p	10	27	and	and	CCONJ
5x21td98j1p	10	28	molecular	molecular	ADJ
5x21td98j1p	10	29	dynamics	dynamic	NOUN
5x21td98j1p	10	30	simulations	simulation	NOUN
5x21td98j1p	10	31	,	,	PUNCT
5x21td98j1p	10	32	and	and	CCONJ
5x21td98j1p	10	33	mm	mm	NOUN
5x21td98j1p	10	34	/	/	SYM
5x21td98j1p	10	35	pbsa	pbsa	NOUN
5x21td98j1p	10	36	binding	bind	VERB
5x21td98j1p	10	37	free	free	ADJ
5x21td98j1p	10	38	energy	energy	NOUN
5x21td98j1p	10	39	calculations	calculation	NOUN
5x21td98j1p	10	40	and	and	CCONJ
5x21td98j1p	10	41	rescoring	rescoring	NOUN
5x21td98j1p	10	42	.	.	PUNCT