id	sid	tid	token	lemma	pos
5t34sj16b7c	1	1	proteins	protein	NOUN
5t34sj16b7c	1	2	participate	participate	VERB
5t34sj16b7c	1	3	in	in	ADP
5t34sj16b7c	1	4	many	many	ADJ
5t34sj16b7c	1	5	important	important	ADJ
5t34sj16b7c	1	6	functions	function	NOUN
5t34sj16b7c	1	7	in	in	ADP
5t34sj16b7c	1	8	the	the	DET
5t34sj16b7c	1	9	cell	cell	NOUN
5t34sj16b7c	1	10	,	,	PUNCT
5t34sj16b7c	1	11	from	from	ADP
5t34sj16b7c	1	12	serving	serve	VERB
5t34sj16b7c	1	13	as	as	ADP
5t34sj16b7c	1	14	catalysts	catalyst	NOUN
5t34sj16b7c	1	15	in	in	ADP
5t34sj16b7c	1	16	biochemical	biochemical	ADJ
5t34sj16b7c	1	17	pathways	pathway	NOUN
5t34sj16b7c	1	18	to	to	ADP
5t34sj16b7c	1	19	providing	provide	VERB
5t34sj16b7c	1	20	structural	structural	ADJ
5t34sj16b7c	1	21	integrity	integrity	NOUN
5t34sj16b7c	1	22	.	.	PUNCT
5t34sj16b7c	2	1	to	to	PART
5t34sj16b7c	2	2	carry	carry	VERB
5t34sj16b7c	2	3	out	out	ADP
5t34sj16b7c	2	4	their	their	PRON
5t34sj16b7c	2	5	functions	function	NOUN
5t34sj16b7c	2	6	,	,	PUNCT
5t34sj16b7c	2	7	proteins	protein	NOUN
5t34sj16b7c	2	8	must	must	AUX
5t34sj16b7c	2	9	fold	fold	VERB
5t34sj16b7c	2	10	into	into	ADP
5t34sj16b7c	2	11	complex	complex	ADJ
5t34sj16b7c	2	12	,	,	PUNCT
5t34sj16b7c	2	13	three	three	NUM
5t34sj16b7c	2	14	-	-	PUNCT
5t34sj16b7c	2	15	dimensional	dimensional	ADJ
5t34sj16b7c	2	16	structures	structure	NOUN
5t34sj16b7c	2	17	.	.	PUNCT
5t34sj16b7c	3	1	if	if	SCONJ
5t34sj16b7c	3	2	proteins	protein	NOUN
5t34sj16b7c	3	3	misfold	misfold	ADJ
5t34sj16b7c	3	4	or	or	CCONJ
5t34sj16b7c	3	5	aggregate	aggregate	NOUN
5t34sj16b7c	3	6	,	,	PUNCT
5t34sj16b7c	3	7	their	their	PRON
5t34sj16b7c	3	8	function	function	NOUN
5t34sj16b7c	3	9	is	be	AUX
5t34sj16b7c	3	10	impaired	impair	VERB
5t34sj16b7c	3	11	,	,	PUNCT
5t34sj16b7c	3	12	which	which	PRON
5t34sj16b7c	3	13	can	can	AUX
5t34sj16b7c	3	14	lead	lead	VERB
5t34sj16b7c	3	15	to	to	ADP
5t34sj16b7c	3	16	disease	disease	NOUN
5t34sj16b7c	3	17	,	,	PUNCT
5t34sj16b7c	3	18	such	such	ADJ
5t34sj16b7c	3	19	as	as	ADP
5t34sj16b7c	3	20	alzheimer	alzheimer	NOUN
5t34sj16b7c	3	21	's	's	PART
5t34sj16b7c	3	22	and	and	CCONJ
5t34sj16b7c	3	23	parkinson	parkinson	NOUN
5t34sj16b7c	3	24	's	's	PART
5t34sj16b7c	3	25	disease	disease	NOUN
5t34sj16b7c	3	26	.	.	PUNCT
5t34sj16b7c	4	1	protein	protein	NOUN
5t34sj16b7c	4	2	folding	fold	VERB
5t34sj16b7c	4	3	to	to	ADP
5t34sj16b7c	4	4	the	the	DET
5t34sj16b7c	4	5	native	native	ADJ
5t34sj16b7c	4	6	state	state	NOUN
5t34sj16b7c	4	7	can	can	AUX
5t34sj16b7c	4	8	be	be	AUX
5t34sj16b7c	4	9	promoted	promote	VERB
5t34sj16b7c	4	10	or	or	CCONJ
5t34sj16b7c	4	11	disrupted	disrupt	VERB
5t34sj16b7c	4	12	by	by	ADP
5t34sj16b7c	4	13	both	both	DET
5t34sj16b7c	4	14	amino	amino	ADJ
5t34sj16b7c	4	15	acid	acid	NOUN
5t34sj16b7c	4	16	identity	identity	NOUN
5t34sj16b7c	4	17	and	and	CCONJ
5t34sj16b7c	4	18	synonymous	synonymous	ADJ
5t34sj16b7c	4	19	codon	codon	NOUN
5t34sj16b7c	4	20	usage	usage	NOUN
5t34sj16b7c	4	21	.	.	PUNCT
5t34sj16b7c	5	1	early	early	ADJ
5t34sj16b7c	5	2	work	work	NOUN
5t34sj16b7c	5	3	by	by	ADP
5t34sj16b7c	5	4	christian	christian	PROPN
5t34sj16b7c	5	5	b.	b.	PROPN
5t34sj16b7c	5	6	anfinsen	anfinsen	PROPN
5t34sj16b7c	5	7	showed	show	VERB
5t34sj16b7c	5	8	that	that	SCONJ
5t34sj16b7c	5	9	the	the	DET
5t34sj16b7c	5	10	amino	amino	NOUN
5t34sj16b7c	5	11	acid	acid	NOUN
5t34sj16b7c	5	12	identity	identity	NOUN
5t34sj16b7c	5	13	was	be	AUX
5t34sj16b7c	5	14	important	important	ADJ
5t34sj16b7c	5	15	for	for	ADP
5t34sj16b7c	5	16	directing	direct	VERB
5t34sj16b7c	5	17	small	small	ADJ
5t34sj16b7c	5	18	proteins	protein	NOUN
5t34sj16b7c	5	19	to	to	ADP
5t34sj16b7c	5	20	their	their	PRON
5t34sj16b7c	5	21	native	native	ADJ
5t34sj16b7c	5	22	state	state	NOUN
5t34sj16b7c	5	23	.	.	PUNCT
5t34sj16b7c	6	1	however	however	ADV
5t34sj16b7c	6	2	,	,	PUNCT
5t34sj16b7c	6	3	the	the	DET
5t34sj16b7c	6	4	information	information	NOUN
5t34sj16b7c	6	5	contained	contain	VERB
5t34sj16b7c	6	6	in	in	ADP
5t34sj16b7c	6	7	amino	amino	NOUN
5t34sj16b7c	6	8	acid	acid	NOUN
5t34sj16b7c	6	9	identity	identity	NOUN
5t34sj16b7c	6	10	alone	alone	ADV
5t34sj16b7c	6	11	is	be	AUX
5t34sj16b7c	6	12	not	not	PART
5t34sj16b7c	6	13	always	always	ADV
5t34sj16b7c	6	14	sufficient	sufficient	ADJ
5t34sj16b7c	6	15	to	to	PART
5t34sj16b7c	6	16	drive	drive	VERB
5t34sj16b7c	6	17	larger	large	ADJ
5t34sj16b7c	6	18	,	,	PUNCT
5t34sj16b7c	6	19	more	more	ADV
5t34sj16b7c	6	20	complex	complex	ADJ
5t34sj16b7c	6	21	proteins	protein	NOUN
5t34sj16b7c	6	22	to	to	ADP
5t34sj16b7c	6	23	their	their	PRON
5t34sj16b7c	6	24	native	native	ADJ
5t34sj16b7c	6	25	state	state	NOUN
5t34sj16b7c	6	26	.	.	PUNCT
5t34sj16b7c	7	1	the	the	DET
5t34sj16b7c	7	2	inability	inability	NOUN
5t34sj16b7c	7	3	of	of	ADP
5t34sj16b7c	7	4	larger	large	ADJ
5t34sj16b7c	7	5	proteins	protein	NOUN
5t34sj16b7c	7	6	to	to	PART
5t34sj16b7c	7	7	refold	refold	VERB
5t34sj16b7c	7	8	in	in	ADP
5t34sj16b7c	7	9	vitro	vitro	X
5t34sj16b7c	7	10	suggests	suggest	VERB
5t34sj16b7c	7	11	that	that	SCONJ
5t34sj16b7c	7	12	cellular	cellular	ADJ
5t34sj16b7c	7	13	context	context	NOUN
5t34sj16b7c	7	14	is	be	AUX
5t34sj16b7c	7	15	crucial	crucial	ADJ
5t34sj16b7c	7	16	for	for	ADP
5t34sj16b7c	7	17	directing	direct	VERB
5t34sj16b7c	7	18	proteins	protein	NOUN
5t34sj16b7c	7	19	to	to	PART
5t34sj16b7c	7	20	fold	fold	VERB
5t34sj16b7c	7	21	properly	properly	ADV
5t34sj16b7c	7	22	.	.	PUNCT
5t34sj16b7c	8	1	in	in	ADP
5t34sj16b7c	8	2	vitro	vitro	X
5t34sj16b7c	8	3	conditions	condition	NOUN
5t34sj16b7c	8	4	lack	lack	NOUN
5t34sj16b7c	8	5	chaperones	chaperone	NOUN
5t34sj16b7c	8	6	,	,	PUNCT
5t34sj16b7c	8	7	cytoplasmic	cytoplasmic	ADJ
5t34sj16b7c	8	8	crowding	crowding	NOUN
5t34sj16b7c	8	9	,	,	PUNCT
5t34sj16b7c	8	10	and	and	CCONJ
5t34sj16b7c	8	11	varying	vary	VERB
5t34sj16b7c	8	12	translation	translation	NOUN
5t34sj16b7c	8	13	elongation	elongation	NOUN
5t34sj16b7c	8	14	rates	rate	NOUN
5t34sj16b7c	8	15	.	.	PUNCT
5t34sj16b7c	9	1	elongation	elongation	NOUN
5t34sj16b7c	9	2	rate	rate	NOUN
5t34sj16b7c	9	3	can	can	AUX
5t34sj16b7c	9	4	be	be	AUX
5t34sj16b7c	9	5	modulated	modulate	VERB
5t34sj16b7c	9	6	by	by	ADP
5t34sj16b7c	9	7	synonymous	synonymous	ADJ
5t34sj16b7c	9	8	codons	codon	NOUN
5t34sj16b7c	9	9	through	through	ADP
5t34sj16b7c	9	10	their	their	PRON
5t34sj16b7c	9	11	variable	variable	ADJ
5t34sj16b7c	9	12	decoding	decode	VERB
5t34sj16b7c	9	13	rates	rate	NOUN
5t34sj16b7c	9	14	and	and	CCONJ
5t34sj16b7c	9	15	can	can	AUX
5t34sj16b7c	9	16	therefore	therefore	ADV
5t34sj16b7c	9	17	influence	influence	VERB
5t34sj16b7c	9	18	the	the	DET
5t34sj16b7c	9	19	co	co	ADJ
5t34sj16b7c	9	20	-	-	ADJ
5t34sj16b7c	9	21	translational	translational	ADJ
5t34sj16b7c	9	22	folding	folding	ADJ
5t34sj16b7c	9	23	process	process	NOUN
5t34sj16b7c	9	24	of	of	ADP
5t34sj16b7c	9	25	the	the	DET
5t34sj16b7c	9	26	nascent	nascent	ADJ
5t34sj16b7c	9	27	protein.progress	protein.progress	NOUN
5t34sj16b7c	9	28	in	in	ADP
5t34sj16b7c	9	29	the	the	DET
5t34sj16b7c	9	30	field	field	NOUN
5t34sj16b7c	9	31	of	of	ADP
5t34sj16b7c	9	32	protein	protein	NOUN
5t34sj16b7c	9	33	folding	folding	NOUN
5t34sj16b7c	9	34	has	have	AUX
5t34sj16b7c	9	35	included	include	VERB
5t34sj16b7c	9	36	the	the	DET
5t34sj16b7c	9	37	understanding	understanding	NOUN
5t34sj16b7c	9	38	that	that	SCONJ
5t34sj16b7c	9	39	a	a	DET
5t34sj16b7c	9	40	sequence	sequence	NOUN
5t34sj16b7c	9	41	containing	contain	VERB
5t34sj16b7c	9	42	more	more	ADV
5t34sj16b7c	9	43	rare	rare	ADJ
5t34sj16b7c	9	44	codon	codon	NOUN
5t34sj16b7c	9	45	substitutions	substitution	NOUN
5t34sj16b7c	9	46	is	be	AUX
5t34sj16b7c	9	47	more	more	ADV
5t34sj16b7c	9	48	likely	likely	ADJ
5t34sj16b7c	9	49	to	to	PART
5t34sj16b7c	9	50	misfold	misfold	ADJ
5t34sj16b7c	9	51	,	,	PUNCT
5t34sj16b7c	9	52	and	and	CCONJ
5t34sj16b7c	9	53	that	that	SCONJ
5t34sj16b7c	9	54	exchanging	exchange	VERB
5t34sj16b7c	9	55	hydrophobic	hydrophobic	NOUN
5t34sj16b7c	9	56	amino	amino	NOUN
5t34sj16b7c	9	57	acids	acid	NOUN
5t34sj16b7c	9	58	with	with	ADP
5t34sj16b7c	9	59	polar	polar	ADJ
5t34sj16b7c	9	60	ones	one	NOUN
5t34sj16b7c	9	61	is	be	AUX
5t34sj16b7c	9	62	likely	likely	ADJ
5t34sj16b7c	9	63	to	to	PART
5t34sj16b7c	9	64	significantly	significantly	ADV
5t34sj16b7c	9	65	disrupt	disrupt	VERB
5t34sj16b7c	9	66	folding	fold	VERB
5t34sj16b7c	9	67	.	.	PUNCT
5t34sj16b7c	10	1	despite	despite	SCONJ
5t34sj16b7c	10	2	these	these	DET
5t34sj16b7c	10	3	significant	significant	ADJ
5t34sj16b7c	10	4	advances	advance	NOUN
5t34sj16b7c	10	5	,	,	PUNCT
5t34sj16b7c	10	6	we	we	PRON
5t34sj16b7c	10	7	are	be	AUX
5t34sj16b7c	10	8	still	still	ADV
5t34sj16b7c	10	9	unable	unable	ADJ
5t34sj16b7c	10	10	to	to	PART
5t34sj16b7c	10	11	build	build	VERB
5t34sj16b7c	10	12	predictive	predictive	ADJ
5t34sj16b7c	10	13	tools	tool	NOUN
5t34sj16b7c	10	14	for	for	ADP
5t34sj16b7c	10	15	protein	protein	NOUN
5t34sj16b7c	10	16	folding	fold	VERB
5t34sj16b7c	10	17	.	.	PUNCT
5t34sj16b7c	11	1	one	one	NUM
5t34sj16b7c	11	2	way	way	NOUN
5t34sj16b7c	11	3	to	to	PART
5t34sj16b7c	11	4	build	build	VERB
5t34sj16b7c	11	5	a	a	DET
5t34sj16b7c	11	6	reliable	reliable	ADJ
5t34sj16b7c	11	7	predictive	predictive	ADJ
5t34sj16b7c	11	8	tool	tool	NOUN
5t34sj16b7c	11	9	for	for	ADP
5t34sj16b7c	11	10	protein	protein	NOUN
5t34sj16b7c	11	11	folding	fold	VERB
5t34sj16b7c	11	12	is	be	AUX
5t34sj16b7c	11	13	to	to	PART
5t34sj16b7c	11	14	couple	couple	VERB
5t34sj16b7c	11	15	large	large	ADJ
5t34sj16b7c	11	16	experimental	experimental	ADJ
5t34sj16b7c	11	17	datasets	dataset	NOUN
5t34sj16b7c	11	18	with	with	ADP
5t34sj16b7c	11	19	machine	machine	NOUN
5t34sj16b7c	11	20	-	-	PUNCT
5t34sj16b7c	11	21	learning	learning	NOUN
5t34sj16b7c	11	22	,	,	PUNCT
5t34sj16b7c	11	23	but	but	CCONJ
5t34sj16b7c	11	24	this	this	PRON
5t34sj16b7c	11	25	has	have	AUX
5t34sj16b7c	11	26	been	be	AUX
5t34sj16b7c	11	27	difficult	difficult	ADJ
5t34sj16b7c	11	28	to	to	PART
5t34sj16b7c	11	29	accomplish	accomplish	VERB
5t34sj16b7c	11	30	due	due	ADP
5t34sj16b7c	11	31	to	to	ADP
5t34sj16b7c	11	32	a	a	DET
5t34sj16b7c	11	33	lack	lack	NOUN
5t34sj16b7c	11	34	of	of	ADP
5t34sj16b7c	11	35	tools	tool	NOUN
5t34sj16b7c	11	36	that	that	PRON
5t34sj16b7c	11	37	can	can	AUX
5t34sj16b7c	11	38	map	map	VERB
5t34sj16b7c	11	39	thousands	thousand	NOUN
5t34sj16b7c	11	40	of	of	ADP
5t34sj16b7c	11	41	protein	protein	NOUN
5t34sj16b7c	11	42	sequences	sequence	NOUN
5t34sj16b7c	11	43	to	to	ADP
5t34sj16b7c	11	44	a	a	DET
5t34sj16b7c	11	45	folding	fold	VERB
5t34sj16b7c	11	46	outcome	outcome	NOUN
5t34sj16b7c	11	47	in	in	ADP
5t34sj16b7c	11	48	the	the	DET
5t34sj16b7c	11	49	cellular	cellular	ADJ
5t34sj16b7c	11	50	environment	environment	NOUN
5t34sj16b7c	11	51	.	.	PUNCT
5t34sj16b7c	12	1	additionally	additionally	ADV
5t34sj16b7c	12	2	,	,	PUNCT
5t34sj16b7c	12	3	synonymous	synonymous	ADJ
5t34sj16b7c	12	4	codons	codon	NOUN
5t34sj16b7c	12	5	are	be	AUX
5t34sj16b7c	12	6	known	know	VERB
5t34sj16b7c	12	7	to	to	PART
5t34sj16b7c	12	8	participate	participate	VERB
5t34sj16b7c	12	9	in	in	ADP
5t34sj16b7c	12	10	many	many	ADJ
5t34sj16b7c	12	11	aspects	aspect	NOUN
5t34sj16b7c	12	12	of	of	ADP
5t34sj16b7c	12	13	functional	functional	ADJ
5t34sj16b7c	12	14	protein	protein	NOUN
5t34sj16b7c	12	15	production	production	NOUN
5t34sj16b7c	12	16	and	and	CCONJ
5t34sj16b7c	12	17	disentangling	disentangle	VERB
5t34sj16b7c	12	18	the	the	DET
5t34sj16b7c	12	19	impact	impact	NOUN
5t34sj16b7c	12	20	of	of	ADP
5t34sj16b7c	12	21	synonymous	synonymous	ADJ
5t34sj16b7c	12	22	codons	codon	NOUN
5t34sj16b7c	12	23	on	on	ADP
5t34sj16b7c	12	24	folding	fold	VERB
5t34sj16b7c	12	25	from	from	ADP
5t34sj16b7c	12	26	their	their	PRON
5t34sj16b7c	12	27	other	other	ADJ
5t34sj16b7c	12	28	effects	effect	NOUN
5t34sj16b7c	12	29	in	in	ADP
5t34sj16b7c	12	30	the	the	DET
5t34sj16b7c	12	31	cell	cell	NOUN
5t34sj16b7c	12	32	has	have	AUX
5t34sj16b7c	12	33	proven	prove	VERB
5t34sj16b7c	12	34	challenging	challenging	ADJ
5t34sj16b7c	12	35	,	,	PUNCT
5t34sj16b7c	12	36	in	in	ADP
5t34sj16b7c	12	37	large	large	ADJ
5t34sj16b7c	12	38	part	part	NOUN
5t34sj16b7c	12	39	due	due	ADP
5t34sj16b7c	12	40	to	to	ADP
5t34sj16b7c	12	41	a	a	DET
5t34sj16b7c	12	42	lack	lack	NOUN
5t34sj16b7c	12	43	of	of	ADP
5t34sj16b7c	12	44	folding	fold	VERB
5t34sj16b7c	12	45	models.in	models.in	NUM
5t34sj16b7c	12	46	chapter	chapter	NOUN
5t34sj16b7c	12	47	2	2	NUM
5t34sj16b7c	12	48	,	,	PUNCT
5t34sj16b7c	12	49	i	i	PRON
5t34sj16b7c	12	50	describe	describe	VERB
5t34sj16b7c	12	51	my	my	PRON
5t34sj16b7c	12	52	use	use	NOUN
5t34sj16b7c	12	53	of	of	ADP
5t34sj16b7c	12	54	the	the	DET
5t34sj16b7c	12	55	previously	previously	ADV
5t34sj16b7c	12	56	established	establish	VERB
5t34sj16b7c	12	57	synonymous	synonymous	ADJ
5t34sj16b7c	12	58	codon	codon	NOUN
5t34sj16b7c	12	59	folding	folding	NOUN
5t34sj16b7c	12	60	model	model	NOUN
5t34sj16b7c	12	61	chloramphenicol	chloramphenicol	NOUN
5t34sj16b7c	12	62	acetyltransferase	acetyltransferase	PROPN
5t34sj16b7c	12	63	iii	iii	PROPN
5t34sj16b7c	12	64	(	(	PUNCT
5t34sj16b7c	12	65	cat	cat	NOUN
5t34sj16b7c	12	66	)	)	PUNCT
5t34sj16b7c	12	67	to	to	PART
5t34sj16b7c	12	68	probe	probe	VERB
5t34sj16b7c	12	69	synonymous	synonymous	ADJ
5t34sj16b7c	12	70	codon	codon	NOUN
5t34sj16b7c	12	71	effects	effect	NOUN
5t34sj16b7c	12	72	on	on	ADP
5t34sj16b7c	12	73	functional	functional	ADJ
5t34sj16b7c	12	74	protein	protein	NOUN
5t34sj16b7c	12	75	production	production	NOUN
5t34sj16b7c	12	76	in	in	ADP
5t34sj16b7c	12	77	e.	e.	PROPN
5t34sj16b7c	12	78	coli	coli	PROPN
5t34sj16b7c	12	79	.	.	PUNCT
5t34sj16b7c	13	1	we	we	PRON
5t34sj16b7c	13	2	define	define	VERB
5t34sj16b7c	13	3	functional	functional	ADJ
5t34sj16b7c	13	4	protein	protein	NOUN
5t34sj16b7c	13	5	production	production	NOUN
5t34sj16b7c	13	6	as	as	ADP
5t34sj16b7c	13	7	the	the	DET
5t34sj16b7c	13	8	net	net	ADJ
5t34sj16b7c	13	9	effect	effect	NOUN
5t34sj16b7c	13	10	of	of	ADP
5t34sj16b7c	13	11	transcription	transcription	NOUN
5t34sj16b7c	13	12	(	(	PUNCT
5t34sj16b7c	13	13	mrna	mrna	PROPN
5t34sj16b7c	13	14	synthesis	synthesis	NOUN
5t34sj16b7c	13	15	)	)	PUNCT
5t34sj16b7c	13	16	,	,	PUNCT
5t34sj16b7c	13	17	mrna	mrna	PROPN
5t34sj16b7c	13	18	half	half	ADJ
5t34sj16b7c	13	19	-	-	PUNCT
5t34sj16b7c	13	20	life	life	NOUN
5t34sj16b7c	13	21	,	,	PUNCT
5t34sj16b7c	13	22	translation	translation	NOUN
5t34sj16b7c	13	23	(	(	PUNCT
5t34sj16b7c	13	24	protein	protein	NOUN
5t34sj16b7c	13	25	synthesis	synthesis	NOUN
5t34sj16b7c	13	26	)	)	PUNCT
5t34sj16b7c	13	27	and	and	CCONJ
5t34sj16b7c	13	28	the	the	DET
5t34sj16b7c	13	29	probability	probability	NOUN
5t34sj16b7c	13	30	of	of	ADP
5t34sj16b7c	13	31	a	a	DET
5t34sj16b7c	13	32	protein	protein	NOUN
5t34sj16b7c	13	33	folding	fold	VERB
5t34sj16b7c	13	34	correctly	correctly	ADV
5t34sj16b7c	13	35	to	to	ADP
5t34sj16b7c	13	36	its	its	PRON
5t34sj16b7c	13	37	active	active	ADJ
5t34sj16b7c	13	38	,	,	PUNCT
5t34sj16b7c	13	39	functional	functional	ADJ
5t34sj16b7c	13	40	structure	structure	NOUN
5t34sj16b7c	13	41	.	.	PUNCT
5t34sj16b7c	14	1	although	although	SCONJ
5t34sj16b7c	14	2	many	many	ADJ
5t34sj16b7c	14	3	synonymous	synonymous	ADJ
5t34sj16b7c	14	4	codon	codon	NOUN
5t34sj16b7c	14	5	substitutions	substitution	NOUN
5t34sj16b7c	14	6	did	do	AUX
5t34sj16b7c	14	7	not	not	PART
5t34sj16b7c	14	8	significantly	significantly	ADV
5t34sj16b7c	14	9	disrupt	disrupt	VERB
5t34sj16b7c	14	10	cat	cat	NOUN
5t34sj16b7c	14	11	protein	protein	NOUN
5t34sj16b7c	14	12	folding	fold	VERB
5t34sj16b7c	14	13	in	in	ADP
5t34sj16b7c	14	14	vivo	vivo	PROPN
5t34sj16b7c	14	15	,	,	PUNCT
5t34sj16b7c	14	16	i	i	PRON
5t34sj16b7c	14	17	discovered	discover	VERB
5t34sj16b7c	14	18	a	a	DET
5t34sj16b7c	14	19	novel	novel	ADJ
5t34sj16b7c	14	20	role	role	NOUN
5t34sj16b7c	14	21	of	of	ADP
5t34sj16b7c	14	22	synonymous	synonymous	ADJ
5t34sj16b7c	14	23	codons	codon	NOUN
5t34sj16b7c	14	24	in	in	ADP
5t34sj16b7c	14	25	functional	functional	ADJ
5t34sj16b7c	14	26	protein	protein	NOUN
5t34sj16b7c	14	27	production	production	NOUN
5t34sj16b7c	14	28	.	.	PUNCT
5t34sj16b7c	15	1	specifically	specifically	ADV
5t34sj16b7c	15	2	,	,	PUNCT
5t34sj16b7c	15	3	synonymous	synonymous	ADJ
5t34sj16b7c	15	4	codon	codon	NOUN
5t34sj16b7c	15	5	substitutions	substitution	NOUN
5t34sj16b7c	15	6	in	in	ADP
5t34sj16b7c	15	7	the	the	DET
5t34sj16b7c	15	8	cat	cat	NOUN
5t34sj16b7c	15	9	gene	gene	NOUN
5t34sj16b7c	15	10	upregulated	upregulate	VERB
5t34sj16b7c	15	11	the	the	DET
5t34sj16b7c	15	12	basal	basal	ADJ
5t34sj16b7c	15	13	expression	expression	NOUN
5t34sj16b7c	15	14	levels	level	NOUN
5t34sj16b7c	15	15	of	of	ADP
5t34sj16b7c	15	16	an	an	DET
5t34sj16b7c	15	17	upstream	upstream	ADJ
5t34sj16b7c	15	18	gene	gene	NOUN
5t34sj16b7c	15	19	which	which	PRON
5t34sj16b7c	15	20	shares	share	VERB
5t34sj16b7c	15	21	a	a	DET
5t34sj16b7c	15	22	promoter	promoter	NOUN
5t34sj16b7c	15	23	with	with	ADP
5t34sj16b7c	15	24	cat	cat	NOUN
5t34sj16b7c	15	25	(	(	PUNCT
5t34sj16b7c	15	26	known	know	VERB
5t34sj16b7c	15	27	as	as	ADP
5t34sj16b7c	15	28	an	an	DET
5t34sj16b7c	15	29	overlapping	overlapping	ADJ
5t34sj16b7c	15	30	,	,	PUNCT
5t34sj16b7c	15	31	divergent	divergent	ADJ
5t34sj16b7c	15	32	promoter	promoter	NOUN
5t34sj16b7c	15	33	,	,	PUNCT
5t34sj16b7c	15	34	odp	odp	PROPN
5t34sj16b7c	15	35	)	)	PUNCT
5t34sj16b7c	15	36	.	.	PUNCT
5t34sj16b7c	16	1	the	the	DET
5t34sj16b7c	16	2	upregulation	upregulation	NOUN
5t34sj16b7c	16	3	of	of	ADP
5t34sj16b7c	16	4	the	the	DET
5t34sj16b7c	16	5	neighboring	neighboring	NOUN
5t34sj16b7c	16	6	gene	gene	NOUN
5t34sj16b7c	16	7	,	,	PUNCT
5t34sj16b7c	16	8	tetr	tetr	PROPN
5t34sj16b7c	16	9	,	,	PUNCT
5t34sj16b7c	16	10	which	which	PRON
5t34sj16b7c	16	11	is	be	AUX
5t34sj16b7c	16	12	a	a	DET
5t34sj16b7c	16	13	transcription	transcription	NOUN
5t34sj16b7c	16	14	factor	factor	NOUN
5t34sj16b7c	16	15	that	that	PRON
5t34sj16b7c	16	16	binds	bind	VERB
5t34sj16b7c	16	17	to	to	ADP
5t34sj16b7c	16	18	the	the	DET
5t34sj16b7c	16	19	shared	share	VERB
5t34sj16b7c	16	20	promoter	promoter	NOUN
5t34sj16b7c	16	21	region	region	NOUN
5t34sj16b7c	16	22	,	,	PUNCT
5t34sj16b7c	16	23	repressed	repress	VERB
5t34sj16b7c	16	24	expression	expression	NOUN
5t34sj16b7c	16	25	of	of	ADP
5t34sj16b7c	16	26	several	several	ADJ
5t34sj16b7c	16	27	synonymous	synonymous	ADJ
5t34sj16b7c	16	28	cat	cat	NOUN
5t34sj16b7c	16	29	mutants	mutant	NOUN
5t34sj16b7c	16	30	.	.	PUNCT
5t34sj16b7c	17	1	increased	increase	VERB
5t34sj16b7c	17	2	repression	repression	NOUN
5t34sj16b7c	17	3	by	by	ADP
5t34sj16b7c	17	4	tetr	tetr	PROPN
5t34sj16b7c	17	5	resulted	result	VERB
5t34sj16b7c	17	6	in	in	ADP
5t34sj16b7c	17	7	decreased	decrease	VERB
5t34sj16b7c	17	8	accumulation	accumulation	NOUN
5t34sj16b7c	17	9	of	of	ADP
5t34sj16b7c	17	10	cat	cat	NOUN
5t34sj16b7c	17	11	which	which	PRON
5t34sj16b7c	17	12	resulted	result	VERB
5t34sj16b7c	17	13	in	in	ADP
5t34sj16b7c	17	14	decreased	decrease	VERB
5t34sj16b7c	17	15	e.	e.	PROPN
5t34sj16b7c	17	16	coli	coli	PROPN
5t34sj16b7c	17	17	fitness	fitness	NOUN
5t34sj16b7c	17	18	when	when	SCONJ
5t34sj16b7c	17	19	cells	cell	NOUN
5t34sj16b7c	17	20	were	be	AUX
5t34sj16b7c	17	21	challenged	challenge	VERB
5t34sj16b7c	17	22	with	with	ADP
5t34sj16b7c	17	23	the	the	DET
5t34sj16b7c	17	24	antibiotic	antibiotic	ADJ
5t34sj16b7c	17	25	cam	cam	NOUN
5t34sj16b7c	17	26	,	,	PUNCT
5t34sj16b7c	17	27	due	due	ADP
5t34sj16b7c	17	28	to	to	ADP
5t34sj16b7c	17	29	insufficient	insufficient	ADJ
5t34sj16b7c	17	30	accumulation	accumulation	NOUN
5t34sj16b7c	17	31	of	of	ADP
5t34sj16b7c	17	32	cat	cat	NOUN
5t34sj16b7c	17	33	to	to	PART
5t34sj16b7c	17	34	fight	fight	VERB
5t34sj16b7c	17	35	off	off	ADP
5t34sj16b7c	17	36	the	the	DET
5t34sj16b7c	17	37	antibiotic	antibiotic	NOUN
5t34sj16b7c	17	38	.	.	PUNCT
5t34sj16b7c	18	1	this	this	PRON
5t34sj16b7c	18	2	is	be	AUX
5t34sj16b7c	18	3	a	a	DET
5t34sj16b7c	18	4	significant	significant	ADJ
5t34sj16b7c	18	5	finding	finding	NOUN
5t34sj16b7c	18	6	given	give	VERB
5t34sj16b7c	18	7	that	that	SCONJ
5t34sj16b7c	18	8	(	(	PUNCT
5t34sj16b7c	18	9	1	1	NUM
5t34sj16b7c	18	10	)	)	PUNCT
5t34sj16b7c	18	11	odp	odp	PROPN
5t34sj16b7c	18	12	's	's	PART
5t34sj16b7c	18	13	are	be	AUX
5t34sj16b7c	18	14	widespread	widespread	ADJ
5t34sj16b7c	18	15	in	in	ADP
5t34sj16b7c	18	16	e.	e.	PROPN
5t34sj16b7c	18	17	coli	coli	PROPN
5t34sj16b7c	18	18	,	,	PUNCT
5t34sj16b7c	18	19	which	which	PRON
5t34sj16b7c	18	20	means	mean	VERB
5t34sj16b7c	18	21	this	this	DET
5t34sj16b7c	18	22	form	form	NOUN
5t34sj16b7c	18	23	of	of	ADP
5t34sj16b7c	18	24	regulation	regulation	NOUN
5t34sj16b7c	18	25	may	may	AUX
5t34sj16b7c	18	26	be	be	AUX
5t34sj16b7c	18	27	pervasive	pervasive	ADJ
5t34sj16b7c	18	28	and	and	CCONJ
5t34sj16b7c	18	29	(	(	PUNCT
5t34sj16b7c	18	30	2	2	X
5t34sj16b7c	18	31	)	)	PUNCT
5t34sj16b7c	18	32	synonymous	synonymous	ADJ
5t34sj16b7c	18	33	codons	codon	NOUN
5t34sj16b7c	18	34	may	may	AUX
5t34sj16b7c	18	35	be	be	AUX
5t34sj16b7c	18	36	under	under	ADP
5t34sj16b7c	18	37	an	an	DET
5t34sj16b7c	18	38	additional	additional	ADJ
5t34sj16b7c	18	39	,	,	PUNCT
5t34sj16b7c	18	40	previously	previously	ADV
5t34sj16b7c	18	41	unrecognized	unrecognized	ADJ
5t34sj16b7c	18	42	selective	selective	ADJ
5t34sj16b7c	18	43	pressure	pressure	NOUN
5t34sj16b7c	18	44	to	to	PART
5t34sj16b7c	18	45	regulate	regulate	VERB
5t34sj16b7c	18	46	expression	expression	NOUN
5t34sj16b7c	18	47	of	of	ADP
5t34sj16b7c	18	48	neighboring	neighbor	VERB
5t34sj16b7c	18	49	genes.in	genes.in	NUM
5t34sj16b7c	18	50	chapter	chapter	NOUN
5t34sj16b7c	18	51	3	3	NUM
5t34sj16b7c	18	52	,	,	PUNCT
5t34sj16b7c	18	53	i	i	PRON
5t34sj16b7c	18	54	describe	describe	VERB
5t34sj16b7c	18	55	the	the	DET
5t34sj16b7c	18	56	development	development	NOUN
5t34sj16b7c	18	57	of	of	ADP
5t34sj16b7c	18	58	a	a	DET
5t34sj16b7c	18	59	protein	protein	NOUN
5t34sj16b7c	18	60	folding	fold	VERB
5t34sj16b7c	18	61	screening	screening	NOUN
5t34sj16b7c	18	62	tool	tool	NOUN
5t34sj16b7c	18	63	(	(	PUNCT
5t34sj16b7c	18	64	folding	fold	VERB
5t34sj16b7c	18	65	reporter	reporter	NOUN
5t34sj16b7c	18	66	)	)	PUNCT
5t34sj16b7c	18	67	that	that	PRON
5t34sj16b7c	18	68	can	can	AUX
5t34sj16b7c	18	69	capture	capture	VERB
5t34sj16b7c	18	70	changes	change	NOUN
5t34sj16b7c	18	71	to	to	ADP
5t34sj16b7c	18	72	folding	fold	VERB
5t34sj16b7c	18	73	upon	upon	ADP
5t34sj16b7c	18	74	amino	amino	NOUN
5t34sj16b7c	18	75	acid	acid	NOUN
5t34sj16b7c	18	76	mutations	mutation	NOUN
5t34sj16b7c	18	77	in	in	ADP
5t34sj16b7c	18	78	the	the	DET
5t34sj16b7c	18	79	context	context	NOUN
5t34sj16b7c	18	80	of	of	ADP
5t34sj16b7c	18	81	the	the	DET
5t34sj16b7c	18	82	cellular	cellular	ADJ
5t34sj16b7c	18	83	environment	environment	NOUN
5t34sj16b7c	18	84	.	.	PUNCT
5t34sj16b7c	19	1	this	this	DET
5t34sj16b7c	19	2	screening	screening	NOUN
5t34sj16b7c	19	3	tool	tool	NOUN
5t34sj16b7c	19	4	enables	enable	VERB
5t34sj16b7c	19	5	the	the	DET
5t34sj16b7c	19	6	rapid	rapid	ADJ
5t34sj16b7c	19	7	screening	screening	NOUN
5t34sj16b7c	19	8	of	of	ADP
5t34sj16b7c	19	9	many	many	ADJ
5t34sj16b7c	19	10	mutants	mutant	NOUN
5t34sj16b7c	19	11	at	at	ADP
5t34sj16b7c	19	12	once	once	ADV
5t34sj16b7c	19	13	for	for	ADP
5t34sj16b7c	19	14	folding	fold	VERB
5t34sj16b7c	19	15	perturbations	perturbation	NOUN
5t34sj16b7c	19	16	.	.	PUNCT
5t34sj16b7c	20	1	rapid	rapid	ADJ
5t34sj16b7c	20	2	in	in	ADP
5t34sj16b7c	20	3	vivo	vivo	NOUN
5t34sj16b7c	20	4	screening	screening	NOUN
5t34sj16b7c	20	5	is	be	AUX
5t34sj16b7c	20	6	necessary	necessary	ADJ
5t34sj16b7c	20	7	for	for	ADP
5t34sj16b7c	20	8	mapping	map	VERB
5t34sj16b7c	20	9	folding	fold	VERB
5t34sj16b7c	20	10	information	information	NOUN
5t34sj16b7c	20	11	to	to	ADP
5t34sj16b7c	20	12	amino	amino	NOUN
5t34sj16b7c	20	13	acid	acid	NOUN
5t34sj16b7c	20	14	sequence	sequence	NOUN
5t34sj16b7c	20	15	to	to	PART
5t34sj16b7c	20	16	couple	couple	VERB
5t34sj16b7c	20	17	with	with	ADP
5t34sj16b7c	20	18	machine	machine	NOUN
5t34sj16b7c	20	19	-	-	PUNCT
5t34sj16b7c	20	20	learning	learning	NOUN
5t34sj16b7c	20	21	and	and	CCONJ
5t34sj16b7c	20	22	for	for	ADP
5t34sj16b7c	20	23	building	build	VERB
5t34sj16b7c	20	24	predictive	predictive	ADJ
5t34sj16b7c	20	25	tools	tool	NOUN
5t34sj16b7c	20	26	that	that	PRON
5t34sj16b7c	20	27	can	can	AUX
5t34sj16b7c	20	28	determine	determine	VERB
5t34sj16b7c	20	29	if	if	SCONJ
5t34sj16b7c	20	30	a	a	DET
5t34sj16b7c	20	31	protein	protein	NOUN
5t34sj16b7c	20	32	is	be	AUX
5t34sj16b7c	20	33	likely	likely	ADJ
5t34sj16b7c	20	34	to	to	PART
5t34sj16b7c	20	35	fold	fold	VERB
5t34sj16b7c	20	36	to	to	ADP
5t34sj16b7c	20	37	its	its	PRON
5t34sj16b7c	20	38	native	native	ADJ
5t34sj16b7c	20	39	state	state	NOUN
5t34sj16b7c	20	40	from	from	ADP
5t34sj16b7c	20	41	amino	amino	ADJ
5t34sj16b7c	20	42	acid	acid	NOUN
5t34sj16b7c	20	43	sequence	sequence	NOUN
5t34sj16b7c	20	44	alone	alone	ADV
5t34sj16b7c	20	45	.	.	PUNCT
5t34sj16b7c	21	1	an	an	DET
5t34sj16b7c	21	2	additional	additional	ADJ
5t34sj16b7c	21	3	promising	promising	ADJ
5t34sj16b7c	21	4	application	application	NOUN
5t34sj16b7c	21	5	of	of	ADP
5t34sj16b7c	21	6	the	the	DET
5t34sj16b7c	21	7	folding	fold	VERB
5t34sj16b7c	21	8	reporter	reporter	NOUN
5t34sj16b7c	21	9	is	be	AUX
5t34sj16b7c	21	10	to	to	PART
5t34sj16b7c	21	11	use	use	VERB
5t34sj16b7c	21	12	it	it	PRON
5t34sj16b7c	21	13	as	as	ADP
5t34sj16b7c	21	14	a	a	DET
5t34sj16b7c	21	15	discovery	discovery	NOUN
5t34sj16b7c	21	16	tool	tool	NOUN
5t34sj16b7c	21	17	for	for	ADP
5t34sj16b7c	21	18	synonymous	synonymous	ADJ
5t34sj16b7c	21	19	codon	codon	NOUN
5t34sj16b7c	21	20	folding	folding	NOUN
5t34sj16b7c	21	21	models	model	NOUN
5t34sj16b7c	21	22	to	to	PART
5t34sj16b7c	21	23	study	study	VERB
5t34sj16b7c	21	24	synonymous	synonymous	ADJ
5t34sj16b7c	21	25	codon	codon	NOUN
5t34sj16b7c	21	26	effects	effect	NOUN
5t34sj16b7c	21	27	experimentally	experimentally	ADV
5t34sj16b7c	21	28	.	.	PUNCT
5t34sj16b7c	22	1	having	have	VERB
5t34sj16b7c	22	2	the	the	DET
5t34sj16b7c	22	3	capability	capability	NOUN
5t34sj16b7c	22	4	to	to	PART
5t34sj16b7c	22	5	rapidly	rapidly	ADV
5t34sj16b7c	22	6	measure	measure	VERB
5t34sj16b7c	22	7	protein	protein	NOUN
5t34sj16b7c	22	8	folding	fold	VERB
5t34sj16b7c	22	9	perturbations	perturbation	NOUN
5t34sj16b7c	22	10	in	in	ADP
5t34sj16b7c	22	11	the	the	DET
5t34sj16b7c	22	12	cell	cell	NOUN
5t34sj16b7c	22	13	will	will	AUX
5t34sj16b7c	22	14	significantly	significantly	ADV
5t34sj16b7c	22	15	expand	expand	VERB
5t34sj16b7c	22	16	our	our	PRON
5t34sj16b7c	22	17	understanding	understanding	NOUN
5t34sj16b7c	22	18	of	of	ADP
5t34sj16b7c	22	19	protein	protein	NOUN
5t34sj16b7c	22	20	folding	fold	VERB
5t34sj16b7c	22	21	by	by	ADP
5t34sj16b7c	22	22	providing	provide	VERB
5t34sj16b7c	22	23	large	large	ADJ
5t34sj16b7c	22	24	amounts	amount	NOUN
5t34sj16b7c	22	25	of	of	ADP
5t34sj16b7c	22	26	in	in	ADP
5t34sj16b7c	22	27	vivo	vivo	ADJ
5t34sj16b7c	22	28	relevant	relevant	ADJ
5t34sj16b7c	22	29	data	datum	NOUN
5t34sj16b7c	22	30	that	that	PRON
5t34sj16b7c	22	31	can	can	AUX
5t34sj16b7c	22	32	be	be	AUX
5t34sj16b7c	22	33	used	use	VERB
5t34sj16b7c	22	34	to	to	PART
5t34sj16b7c	22	35	predict	predict	VERB
5t34sj16b7c	22	36	folding	fold	VERB
5t34sj16b7c	22	37	outcomes	outcome	NOUN
5t34sj16b7c	22	38	and	and	CCONJ
5t34sj16b7c	22	39	to	to	PART
5t34sj16b7c	22	40	identify	identify	VERB
5t34sj16b7c	22	41	new	new	ADJ
5t34sj16b7c	22	42	folding	fold	VERB
5t34sj16b7c	22	43	models	model	NOUN
5t34sj16b7c	22	44	.	.	PUNCT