id	sid	tid	token	lemma	pos
5q47rn31z3f	1	1	structure	structure	NOUN
5q47rn31z3f	1	2	based	base	VERB
5q47rn31z3f	1	3	computer	computer	NOUN
5q47rn31z3f	1	4	aided	aid	VERB
5q47rn31z3f	1	5	drug	drug	NOUN
5q47rn31z3f	1	6	design	design	NOUN
5q47rn31z3f	1	7	has	have	AUX
5q47rn31z3f	1	8	been	be	AUX
5q47rn31z3f	1	9	proven	prove	VERB
5q47rn31z3f	1	10	as	as	ADP
5q47rn31z3f	1	11	a	a	DET
5q47rn31z3f	1	12	potent	potent	ADJ
5q47rn31z3f	1	13	tool	tool	NOUN
5q47rn31z3f	1	14	in	in	ADP
5q47rn31z3f	1	15	identifying	identify	VERB
5q47rn31z3f	1	16	lead	lead	NOUN
5q47rn31z3f	1	17	molecules	molecule	NOUN
5q47rn31z3f	1	18	for	for	ADP
5q47rn31z3f	1	19	drug	drug	NOUN
5q47rn31z3f	1	20	targets	target	NOUN
5q47rn31z3f	1	21	,	,	PUNCT
5q47rn31z3f	1	22	with	with	ADP
5q47rn31z3f	1	23	the	the	DET
5q47rn31z3f	1	24	increasing	increase	VERB
5q47rn31z3f	1	25	number	number	NOUN
5q47rn31z3f	1	26	of	of	ADP
5q47rn31z3f	1	27	x	x	NOUN
5q47rn31z3f	1	28	-	-	NOUN
5q47rn31z3f	1	29	ray	ray	NOUN
5q47rn31z3f	1	30	structures	structure	NOUN
5q47rn31z3f	1	31	,	,	PUNCT
5q47rn31z3f	1	32	validated	validate	VERB
5q47rn31z3f	1	33	drug	drug	NOUN
5q47rn31z3f	1	34	targets	target	NOUN
5q47rn31z3f	1	35	and	and	CCONJ
5q47rn31z3f	1	36	the	the	DET
5q47rn31z3f	1	37	ever	ever	ADV
5q47rn31z3f	1	38	increasing	increase	VERB
5q47rn31z3f	1	39	computer	computer	NOUN
5q47rn31z3f	1	40	power	power	NOUN
5q47rn31z3f	1	41	.	.	PUNCT
5q47rn31z3f	2	1	in	in	ADP
5q47rn31z3f	2	2	my	my	PRON
5q47rn31z3f	2	3	thesis	thesis	NOUN
5q47rn31z3f	2	4	,	,	PUNCT
5q47rn31z3f	2	5	i	i	PRON
5q47rn31z3f	2	6	have	have	AUX
5q47rn31z3f	2	7	applied	apply	VERB
5q47rn31z3f	2	8	the	the	DET
5q47rn31z3f	2	9	structure	structure	NOUN
5q47rn31z3f	2	10	based	base	VERB
5q47rn31z3f	2	11	drug	drug	NOUN
5q47rn31z3f	2	12	design	design	NOUN
5q47rn31z3f	2	13	for	for	ADP
5q47rn31z3f	2	14	multiple	multiple	ADJ
5q47rn31z3f	2	15	target	target	NOUN
5q47rn31z3f	2	16	families	family	NOUN
5q47rn31z3f	2	17	including	include	VERB
5q47rn31z3f	2	18	antibiotics	antibiotic	NOUN
5q47rn31z3f	2	19	targets	target	NOUN
5q47rn31z3f	2	20	(	(	PUNCT
5q47rn31z3f	2	21	enzymes	enzyme	NOUN
5q47rn31z3f	2	22	)	)	PUNCT
5q47rn31z3f	2	23	,	,	PUNCT
5q47rn31z3f	2	24	transcription	transcription	NOUN
5q47rn31z3f	2	25	factors	factor	NOUN
5q47rn31z3f	2	26	and	and	CCONJ
5q47rn31z3f	2	27	epigenetic	epigenetic	ADJ
5q47rn31z3f	2	28	readers	reader	NOUN
5q47rn31z3f	2	29	.	.	PUNCT
5q47rn31z3f	3	1	the	the	DET
5q47rn31z3f	3	2	computational	computational	ADJ
5q47rn31z3f	3	3	techniques	technique	NOUN
5q47rn31z3f	3	4	i	i	PRON
5q47rn31z3f	3	5	have	have	AUX
5q47rn31z3f	3	6	used	use	VERB
5q47rn31z3f	3	7	to	to	PART
5q47rn31z3f	3	8	study	study	VERB
5q47rn31z3f	3	9	these	these	DET
5q47rn31z3f	3	10	systems	system	NOUN
5q47rn31z3f	3	11	are	be	AUX
5q47rn31z3f	3	12	mainly	mainly	ADV
5q47rn31z3f	3	13	docking	dock	VERB
5q47rn31z3f	3	14	,	,	PUNCT
5q47rn31z3f	3	15	molecular	molecular	ADJ
5q47rn31z3f	3	16	dynamics	dynamic	NOUN
5q47rn31z3f	3	17	simulation	simulation	NOUN
5q47rn31z3f	3	18	,	,	PUNCT
5q47rn31z3f	3	19	mmgbsa	mmgbsa	NOUN
5q47rn31z3f	3	20	binding	bind	VERB
5q47rn31z3f	3	21	free	free	ADJ
5q47rn31z3f	3	22	energy	energy	NOUN
5q47rn31z3f	3	23	calculation	calculation	NOUN
5q47rn31z3f	3	24	and	and	CCONJ
5q47rn31z3f	3	25	homology	homology	NOUN
5q47rn31z3f	3	26	modeling	modeling	NOUN
5q47rn31z3f	3	27	.	.	PUNCT
5q47rn31z3f	4	1	these	these	DET
5q47rn31z3f	4	2	techniques	technique	NOUN
5q47rn31z3f	4	3	are	be	AUX
5q47rn31z3f	4	4	fast	fast	ADJ
5q47rn31z3f	4	5	,	,	PUNCT
5q47rn31z3f	4	6	cost	cost	VERB
5q47rn31z3f	4	7	efficient	efficient	ADJ
5q47rn31z3f	4	8	and	and	CCONJ
5q47rn31z3f	4	9	can	can	AUX
5q47rn31z3f	4	10	provide	provide	VERB
5q47rn31z3f	4	11	mechanisms	mechanism	NOUN
5q47rn31z3f	4	12	of	of	ADP
5q47rn31z3f	4	13	binding	bind	VERB
5q47rn31z3f	4	14	.	.	PUNCT
5q47rn31z3f	5	1	my	my	PRON
5q47rn31z3f	5	2	major	major	ADJ
5q47rn31z3f	5	3	project	project	NOUN
5q47rn31z3f	5	4	is	be	AUX
5q47rn31z3f	5	5	to	to	PART
5q47rn31z3f	5	6	develop	develop	VERB
5q47rn31z3f	5	7	a	a	DET
5q47rn31z3f	5	8	blueprint	blueprint	NOUN
5q47rn31z3f	5	9	for	for	ADP
5q47rn31z3f	5	10	antimicrobial	antimicrobial	ADJ
5q47rn31z3f	5	11	hit	hit	NOUN
5q47rn31z3f	5	12	discovery	discovery	NOUN
5q47rn31z3f	5	13	targeting	target	VERB
5q47rn31z3f	5	14	metabolic	metabolic	NOUN
5q47rn31z3f	5	15	networks	network	NOUN
5q47rn31z3f	5	16	.	.	PUNCT
5q47rn31z3f	6	1	to	to	PART
5q47rn31z3f	6	2	illustrate	illustrate	VERB
5q47rn31z3f	6	3	this	this	DET
5q47rn31z3f	6	4	methodology	methodology	NOUN
5q47rn31z3f	6	5	,	,	PUNCT
5q47rn31z3f	6	6	e.	e.	PROPN
5q47rn31z3f	6	7	coli	coli	PROPN
5q47rn31z3f	6	8	&	&	CCONJ
5q47rn31z3f	6	9	s.	s.	PROPN
5q47rn31z3f	6	10	aureus	aureus	PROPN
5q47rn31z3f	6	11	were	be	AUX
5q47rn31z3f	6	12	used	use	VERB
5q47rn31z3f	6	13	as	as	ADP
5q47rn31z3f	6	14	examples	example	NOUN
5q47rn31z3f	6	15	for	for	ADP
5q47rn31z3f	6	16	which	which	PRON
5q47rn31z3f	6	17	multiple	multiple	ADJ
5q47rn31z3f	6	18	inhibitors	inhibitor	NOUN
5q47rn31z3f	6	19	have	have	AUX
5q47rn31z3f	6	20	been	be	AUX
5q47rn31z3f	6	21	discovered	discover	VERB
5q47rn31z3f	6	22	.	.	PUNCT
5q47rn31z3f	7	1	system	system	NOUN
5q47rn31z3f	7	2	-	-	PUNCT
5q47rn31z3f	7	3	level	level	NOUN
5q47rn31z3f	7	4	identification	identification	NOUN
5q47rn31z3f	7	5	of	of	ADP
5q47rn31z3f	7	6	drug	drug	NOUN
5q47rn31z3f	7	7	targets	target	NOUN
5q47rn31z3f	7	8	was	be	AUX
5q47rn31z3f	7	9	achieved	achieve	VERB
5q47rn31z3f	7	10	through	through	ADP
5q47rn31z3f	7	11	metabolic	metabolic	ADJ
5q47rn31z3f	7	12	network	network	NOUN
5q47rn31z3f	7	13	construction	construction	NOUN
5q47rn31z3f	7	14	of	of	ADP
5q47rn31z3f	7	15	e.	e.	PROPN
5q47rn31z3f	7	16	coli	coli	PROPN
5q47rn31z3f	7	17	&	&	CCONJ
5q47rn31z3f	7	18	s.	s.	PROPN
5q47rn31z3f	7	19	aureus	aureus	PROPN
5q47rn31z3f	7	20	.	.	PUNCT
5q47rn31z3f	8	1	this	this	PRON
5q47rn31z3f	8	2	is	be	AUX
5q47rn31z3f	8	3	followed	follow	VERB
5q47rn31z3f	8	4	by	by	ADP
5q47rn31z3f	8	5	atomistic	atomistic	ADJ
5q47rn31z3f	8	6	modeling	modeling	NOUN
5q47rn31z3f	8	7	of	of	ADP
5q47rn31z3f	8	8	small	small	ADJ
5q47rn31z3f	8	9	molecules	molecule	NOUN
5q47rn31z3f	8	10	capable	capable	ADJ
5q47rn31z3f	8	11	of	of	ADP
5q47rn31z3f	8	12	modulating	modulate	VERB
5q47rn31z3f	8	13	the	the	DET
5q47rn31z3f	8	14	targets	target	NOUN
5q47rn31z3f	8	15	'	'	PART
5q47rn31z3f	8	16	activity	activity	NOUN
5q47rn31z3f	8	17	and	and	CCONJ
5q47rn31z3f	8	18	in	in	ADP
5q47rn31z3f	8	19	vitro	vitro	X
5q47rn31z3f	8	20	enzyme	enzyme	NOUN
5q47rn31z3f	8	21	and	and	CCONJ
5q47rn31z3f	8	22	cell	cell	NOUN
5q47rn31z3f	8	23	viability	viability	NOUN
5q47rn31z3f	8	24	assays	assay	VERB
5q47rn31z3f	8	25	to	to	PART
5q47rn31z3f	8	26	test	test	VERB
5q47rn31z3f	8	27	the	the	DET
5q47rn31z3f	8	28	activities	activity	NOUN
5q47rn31z3f	8	29	of	of	ADP
5q47rn31z3f	8	30	the	the	DET
5q47rn31z3f	8	31	predicted	predict	VERB
5q47rn31z3f	8	32	inhibitors	inhibitor	NOUN
5q47rn31z3f	8	33	.	.	PUNCT
5q47rn31z3f	9	1	this	this	DET
5q47rn31z3f	9	2	project	project	NOUN
5q47rn31z3f	9	3	combines	combine	VERB
5q47rn31z3f	9	4	genome	genome	NOUN
5q47rn31z3f	9	5	analysis	analysis	NOUN
5q47rn31z3f	9	6	,	,	PUNCT
5q47rn31z3f	9	7	network	network	NOUN
5q47rn31z3f	9	8	biology	biology	NOUN
5q47rn31z3f	9	9	and	and	CCONJ
5q47rn31z3f	9	10	computational	computational	ADJ
5q47rn31z3f	9	11	chemistry	chemistry	NOUN
5q47rn31z3f	9	12	,	,	PUNCT
5q47rn31z3f	9	13	which	which	PRON
5q47rn31z3f	9	14	provides	provide	VERB
5q47rn31z3f	9	15	a	a	DET
5q47rn31z3f	9	16	general	general	ADJ
5q47rn31z3f	9	17	strategy	strategy	NOUN
5q47rn31z3f	9	18	for	for	ADP
5q47rn31z3f	9	19	strain	strain	NOUN
5q47rn31z3f	9	20	-	-	PUNCT
5q47rn31z3f	9	21	specific	specific	ADJ
5q47rn31z3f	9	22	anti	anti	ADJ
5q47rn31z3f	9	23	-	-	ADJ
5q47rn31z3f	9	24	infective	infective	ADJ
5q47rn31z3f	9	25	therapy	therapy	NOUN
5q47rn31z3f	9	26	.	.	PUNCT
5q47rn31z3f	10	1	my	my	PRON
5q47rn31z3f	10	2	contribution	contribution	NOUN
5q47rn31z3f	10	3	to	to	ADP
5q47rn31z3f	10	4	this	this	DET
5q47rn31z3f	10	5	project	project	NOUN
5q47rn31z3f	10	6	includes	include	VERB
5q47rn31z3f	10	7	both	both	DET
5q47rn31z3f	10	8	computational	computational	ADJ
5q47rn31z3f	10	9	prediction	prediction	NOUN
5q47rn31z3f	10	10	of	of	ADP
5q47rn31z3f	10	11	potential	potential	ADJ
5q47rn31z3f	10	12	inhibitors	inhibitor	NOUN
5q47rn31z3f	10	13	and	and	CCONJ
5q47rn31z3f	10	14	experimental	experimental	ADJ
5q47rn31z3f	10	15	validation	validation	NOUN
5q47rn31z3f	10	16	of	of	ADP
5q47rn31z3f	10	17	their	their	PRON
5q47rn31z3f	10	18	activities	activity	NOUN
5q47rn31z3f	10	19	in	in	ADP
5q47rn31z3f	10	20	both	both	PRON
5q47rn31z3f	10	21	in	in	ADP
5q47rn31z3f	10	22	vitro	vitro	X
5q47rn31z3f	10	23	and	and	CCONJ
5q47rn31z3f	10	24	bacterial	bacterial	ADJ
5q47rn31z3f	10	25	cell	cell	NOUN
5q47rn31z3f	10	26	viability	viability	NOUN
5q47rn31z3f	10	27	.	.	PUNCT
5q47rn31z3f	11	1	my	my	PRON
5q47rn31z3f	11	2	second	second	ADJ
5q47rn31z3f	11	3	project	project	NOUN
5q47rn31z3f	11	4	involves	involve	VERB
5q47rn31z3f	11	5	designing	design	VERB
5q47rn31z3f	11	6	peptide	peptide	NOUN
5q47rn31z3f	11	7	analogs	analog	NOUN
5q47rn31z3f	11	8	to	to	PART
5q47rn31z3f	11	9	disrupt	disrupt	VERB
5q47rn31z3f	11	10	the	the	DET
5q47rn31z3f	11	11	protein	protein	NOUN
5q47rn31z3f	11	12	-	-	PUNCT
5q47rn31z3f	11	13	protein	protein	NOUN
5q47rn31z3f	11	14	interactions	interaction	NOUN
5q47rn31z3f	11	15	of	of	ADP
5q47rn31z3f	11	16	the	the	DET
5q47rn31z3f	11	17	notch	notch	ADJ
5q47rn31z3f	11	18	transactivation	transactivation	NOUN
5q47rn31z3f	11	19	complex	complex	NOUN
5q47rn31z3f	11	20	,	,	PUNCT
5q47rn31z3f	11	21	the	the	DET
5q47rn31z3f	11	22	loose	loose	ADJ
5q47rn31z3f	11	23	or	or	CCONJ
5q47rn31z3f	11	24	gain	gain	VERB
5q47rn31z3f	11	25	-	-	PUNCT
5q47rn31z3f	11	26	of	of	ADP
5q47rn31z3f	11	27	-	-	PUNCT
5q47rn31z3f	11	28	function	function	NOUN
5q47rn31z3f	11	29	of	of	ADP
5q47rn31z3f	11	30	mutations	mutation	NOUN
5q47rn31z3f	11	31	of	of	ADP
5q47rn31z3f	11	32	which	which	PRON
5q47rn31z3f	11	33	are	be	AUX
5q47rn31z3f	11	34	related	relate	VERB
5q47rn31z3f	11	35	with	with	ADP
5q47rn31z3f	11	36	various	various	ADJ
5q47rn31z3f	11	37	diseases	disease	NOUN
5q47rn31z3f	11	38	,	,	PUNCT
5q47rn31z3f	11	39	including	include	VERB
5q47rn31z3f	11	40	cancer	cancer	NOUN
5q47rn31z3f	11	41	.	.	PUNCT
5q47rn31z3f	12	1	i	i	PRON
5q47rn31z3f	12	2	have	have	AUX
5q47rn31z3f	12	3	identified	identify	VERB
5q47rn31z3f	12	4	binding	binding	ADJ
5q47rn31z3f	12	5	hot	hot	ADJ
5q47rn31z3f	12	6	-	-	PUNCT
5q47rn31z3f	12	7	spots	spot	NOUN
5q47rn31z3f	12	8	of	of	ADP
5q47rn31z3f	12	9	maml	maml	PROPN
5q47rn31z3f	12	10	&	&	CCONJ
5q47rn31z3f	12	11	csl	csl	PROPN
5q47rn31z3f	12	12	/	/	PROPN
5q47rn31z3f	12	13	ank	ank	PROPN
5q47rn31z3f	12	14	interface	interface	NOUN
5q47rn31z3f	12	15	through	through	ADP
5q47rn31z3f	12	16	mmgbsa	mmgbsa	NOUN
5q47rn31z3f	12	17	energy	energy	NOUN
5q47rn31z3f	12	18	decomposition	decomposition	NOUN
5q47rn31z3f	12	19	.	.	PUNCT
5q47rn31z3f	13	1	stapled	stapled	ADJ
5q47rn31z3f	13	2	peptide	peptide	NOUN
5q47rn31z3f	13	3	analogs	analog	NOUN
5q47rn31z3f	13	4	of	of	ADP
5q47rn31z3f	13	5	natural	natural	ADJ
5q47rn31z3f	13	6	maml	maml	NOUN
5q47rn31z3f	13	7	are	be	AUX
5q47rn31z3f	13	8	then	then	ADV
5q47rn31z3f	13	9	computationally	computationally	ADV
5q47rn31z3f	13	10	designed	design	VERB
5q47rn31z3f	13	11	with	with	ADP
5q47rn31z3f	13	12	mutations	mutation	NOUN
5q47rn31z3f	13	13	around	around	ADP
5q47rn31z3f	13	14	the	the	DET
5q47rn31z3f	13	15	hot	hot	ADJ
5q47rn31z3f	13	16	-	-	PUNCT
5q47rn31z3f	13	17	spots	spot	NOUN
5q47rn31z3f	13	18	to	to	ADP
5q47rn31z3f	13	19	other	other	ADJ
5q47rn31z3f	13	20	residues	residue	NOUN
5q47rn31z3f	13	21	or	or	CCONJ
5q47rn31z3f	13	22	non	non	ADJ
5q47rn31z3f	13	23	-	-	ADJ
5q47rn31z3f	13	24	natural	natural	ADJ
5q47rn31z3f	13	25	amino	amino	NOUN
5q47rn31z3f	13	26	acids	acid	NOUN
5q47rn31z3f	13	27	using	use	VERB
5q47rn31z3f	13	28	md	md	PROPN
5q47rn31z3f	13	29	simulations	simulation	NOUN
5q47rn31z3f	13	30	and	and	CCONJ
5q47rn31z3f	13	31	mmgbsa	mmgbsa	NOUN
5q47rn31z3f	13	32	rescoring	rescore	VERB
5q47rn31z3f	13	33	,	,	PUNCT
5q47rn31z3f	13	34	which	which	PRON
5q47rn31z3f	13	35	have	have	AUX
5q47rn31z3f	13	36	been	be	AUX
5q47rn31z3f	13	37	subsequently	subsequently	ADV
5q47rn31z3f	13	38	validated	validate	VERB
5q47rn31z3f	13	39	experimentally	experimentally	NOUN
5q47rn31z3f	13	40	by	by	ADP
5q47rn31z3f	13	41	our	our	PRON
5q47rn31z3f	13	42	collaborators	collaborator	NOUN
5q47rn31z3f	13	43	to	to	PART
5q47rn31z3f	13	44	have	have	VERB
5q47rn31z3f	13	45	stronger	strong	ADJ
5q47rn31z3f	13	46	potency	potency	NOUN
5q47rn31z3f	13	47	.	.	PUNCT
5q47rn31z3f	14	1	my	my	PRON
5q47rn31z3f	14	2	third	third	ADJ
5q47rn31z3f	14	3	project	project	NOUN
5q47rn31z3f	14	4	is	be	AUX
5q47rn31z3f	14	5	studying	study	VERB
5q47rn31z3f	14	6	a	a	DET
5q47rn31z3f	14	7	small	small	ADJ
5q47rn31z3f	14	8	molecule	molecule	NOUN
5q47rn31z3f	14	9	inhibitor	inhibitor	NOUN
5q47rn31z3f	14	10	ì¢	ì¢	VERB
5q47rn31z3f	14	11	ââ	ââ	NOUN
5q47rn31z3f	14	12	'	'	PUNCT
5q47rn31z3f	14	13	(	(	PUNCT
5q47rn31z3f	14	14	+	+	NOUN
5q47rn31z3f	14	15	)	)	PUNCT
5q47rn31z3f	14	16	-jq1	-jq1	PUNCT
5q47rn31z3f	14	17	targeting	target	VERB
5q47rn31z3f	14	18	bromodomains	bromodomain	NOUN
5q47rn31z3f	14	19	for	for	ADP
5q47rn31z3f	14	20	potential	potential	ADJ
5q47rn31z3f	14	21	cancer	cancer	NOUN
5q47rn31z3f	14	22	therapy	therapy	NOUN
5q47rn31z3f	14	23	.	.	PUNCT
5q47rn31z3f	15	1	using	use	VERB
5q47rn31z3f	15	2	docking	docking	NOUN
5q47rn31z3f	15	3	and	and	CCONJ
5q47rn31z3f	15	4	molecular	molecular	ADJ
5q47rn31z3f	15	5	dynamics	dynamic	NOUN
5q47rn31z3f	15	6	simulation	simulation	NOUN
5q47rn31z3f	15	7	,	,	PUNCT
5q47rn31z3f	15	8	i	i	PRON
5q47rn31z3f	15	9	explained	explain	VERB
5q47rn31z3f	15	10	the	the	DET
5q47rn31z3f	15	11	selectivity	selectivity	NOUN
5q47rn31z3f	15	12	of	of	ADP
5q47rn31z3f	15	13	brd4(1	brd4(1	PROPN
5q47rn31z3f	15	14	)	)	PUNCT
5q47rn31z3f	15	15	over	over	ADP
5q47rn31z3f	15	16	jq1	jq1	PROPN
5q47rn31z3f	15	17	enantiomers	enantiomer	NOUN
5q47rn31z3f	15	18	and	and	CCONJ
5q47rn31z3f	15	19	the	the	DET
5q47rn31z3f	15	20	different	different	ADJ
5q47rn31z3f	15	21	binding	binding	ADJ
5q47rn31z3f	15	22	modes	mode	NOUN
5q47rn31z3f	15	23	of	of	ADP
5q47rn31z3f	15	24	brd3(1	brd3(1	NOUN
5q47rn31z3f	15	25	)	)	PUNCT
5q47rn31z3f	15	26	and	and	CCONJ
5q47rn31z3f	15	27	brd3(2	brd3(2	PROPN
5q47rn31z3f	15	28	)	)	PUNCT
5q47rn31z3f	15	29	with	with	ADP
5q47rn31z3f	15	30	(	(	PUNCT
5q47rn31z3f	15	31	+	+	NOUN
5q47rn31z3f	15	32	)	)	PUNCT
5q47rn31z3f	15	33	-jq1	-jq1	NOUN
5q47rn31z3f	15	34	.	.	PUNCT