id sid tid token lemma pos 5712m615j0z 1 1 zinc(ii)-bis(dipicolylamine zinc(ii)-bis(dipicolylamine NUM 5712m615j0z 1 2 ) ) PUNCT 5712m615j0z 1 3 ( ( PUNCT 5712m615j0z 1 4 zn zn NOUN 5712m615j0z 1 5 - - PUNCT 5712m615j0z 1 6 bdpa bdpa NOUN 5712m615j0z 1 7 ) ) PUNCT 5712m615j0z 1 8 coordination coordination NOUN 5712m615j0z 1 9 complexes complex NOUN 5712m615j0z 1 10 selectively selectively ADV 5712m615j0z 1 11 target target VERB 5712m615j0z 1 12 the the DET 5712m615j0z 1 13 surfaces surface NOUN 5712m615j0z 1 14 of of ADP 5712m615j0z 1 15 dead dead ADJ 5712m615j0z 1 16 and and CCONJ 5712m615j0z 1 17 dying die VERB 5712m615j0z 1 18 mammalian mammalian ADJ 5712m615j0z 1 19 cells cell NOUN 5712m615j0z 1 20 , , PUNCT 5712m615j0z 1 21 and and CCONJ 5712m615j0z 1 22 they they PRON 5712m615j0z 1 23 have have VERB 5712m615j0z 1 24 promise promise NOUN 5712m615j0z 1 25 as as ADP 5712m615j0z 1 26 molecular molecular ADJ 5712m615j0z 1 27 probes probe NOUN 5712m615j0z 1 28 for for ADP 5712m615j0z 1 29 imaging image VERB 5712m615j0z 1 30 cell cell NOUN 5712m615j0z 1 31 death death NOUN 5712m615j0z 1 32 . . PUNCT 5712m615j0z 2 1 a a DET 5712m615j0z 2 2 necessary necessary ADJ 5712m615j0z 2 3 step step NOUN 5712m615j0z 2 4 towards towards ADP 5712m615j0z 2 5 eventual eventual ADJ 5712m615j0z 2 6 clinical clinical ADJ 5712m615j0z 2 7 imaging imaging NOUN 5712m615j0z 2 8 applications application NOUN 5712m615j0z 2 9 is be AUX 5712m615j0z 2 10 the the DET 5712m615j0z 2 11 development development NOUN 5712m615j0z 2 12 of of ADP 5712m615j0z 2 13 next next ADJ 5712m615j0z 2 14 - - PUNCT 5712m615j0z 2 15 generation generation NOUN 5712m615j0z 2 16 zn zn X 5712m615j0z 2 17 - - PUNCT 5712m615j0z 2 18 bdpa bdpa ADJ 5712m615j0z 2 19 complexes complex NOUN 5712m615j0z 2 20 with with ADP 5712m615j0z 2 21 enhanced enhanced ADJ 5712m615j0z 2 22 affinity affinity NOUN 5712m615j0z 2 23 for for ADP 5712m615j0z 2 24 the the DET 5712m615j0z 2 25 cell cell NOUN 5712m615j0z 2 26 death death NOUN 5712m615j0z 2 27 membrane membrane NOUN 5712m615j0z 2 28 biomarker biomarker NOUN 5712m615j0z 2 29 , , PUNCT 5712m615j0z 2 30 phosphatidylserine phosphatidylserine NOUN 5712m615j0z 2 31 ( ( PUNCT 5712m615j0z 2 32 ps ps PROPN 5712m615j0z 2 33 ) ) PUNCT 5712m615j0z 2 34 . . PUNCT 5712m615j0z 3 1 this this DET 5712m615j0z 3 2 dissertation dissertation NOUN 5712m615j0z 3 3 documents document VERB 5712m615j0z 3 4 the the DET 5712m615j0z 3 5 development development NOUN 5712m615j0z 3 6 of of ADP 5712m615j0z 3 7 next next ADJ 5712m615j0z 3 8 - - PUNCT 5712m615j0z 3 9 generation generation NOUN 5712m615j0z 3 10 zn zn X 5712m615j0z 3 11 - - PUNCT 5712m615j0z 3 12 bdpa bdpa ADJ 5712m615j0z 3 13 structures structure NOUN 5712m615j0z 3 14 that that PRON 5712m615j0z 3 15 have have VERB 5712m615j0z 3 16 high high ADJ 5712m615j0z 3 17 and and CCONJ 5712m615j0z 3 18 selective selective ADJ 5712m615j0z 3 19 affinity affinity NOUN 5712m615j0z 3 20 for for ADP 5712m615j0z 3 21 ps ps PROPN 5712m615j0z 3 22 - - PUNCT 5712m615j0z 3 23 rich rich ADJ 5712m615j0z 3 24 membrane membrane NOUN 5712m615j0z 3 25 surfaces surface NOUN 5712m615j0z 3 26 . . PUNCT 5712m615j0z 4 1 this this DET 5712m615j0z 4 2 thesis thesis NOUN 5712m615j0z 4 3 begins begin VERB 5712m615j0z 4 4 with with ADP 5712m615j0z 4 5 a a DET 5712m615j0z 4 6 discussion discussion NOUN 5712m615j0z 4 7 of of ADP 5712m615j0z 4 8 the the DET 5712m615j0z 4 9 challenges challenge NOUN 5712m615j0z 4 10 encountered encounter VERB 5712m615j0z 4 11 while while SCONJ 5712m615j0z 4 12 developing develop VERB 5712m615j0z 4 13 small small ADJ 5712m615j0z 4 14 molecule molecule NOUN 5712m615j0z 4 15 synthetic synthetic ADJ 5712m615j0z 4 16 receptors receptor NOUN 5712m615j0z 4 17 that that PRON 5712m615j0z 4 18 mimic mimic VERB 5712m615j0z 4 19 metaloproteins metaloprotein NOUN 5712m615j0z 4 20 for for ADP 5712m615j0z 4 21 equilibrium equilibrium NOUN 5712m615j0z 4 22 binding bind VERB 5712m615j0z 4 23 applications application NOUN 5712m615j0z 4 24 . . PUNCT 5712m615j0z 5 1 chapter chapter NOUN 5712m615j0z 5 2 1 1 NUM 5712m615j0z 5 3 describes describe VERB 5712m615j0z 5 4 the the DET 5712m615j0z 5 5 interplay interplay NOUN 5712m615j0z 5 6 between between ADP 5712m615j0z 5 7 enthalpic enthalpic NOUN 5712m615j0z 5 8 and and CCONJ 5712m615j0z 5 9 entropic entropic ADJ 5712m615j0z 5 10 affects affect VERB 5712m615j0z 5 11 for for ADP 5712m615j0z 5 12 anion anion NOUN 5712m615j0z 5 13 recognition recognition NOUN 5712m615j0z 5 14 using use VERB 5712m615j0z 5 15 structurally structurally ADV 5712m615j0z 5 16 modified modify VERB 5712m615j0z 5 17 synthetic synthetic ADJ 5712m615j0z 5 18 receptors receptor NOUN 5712m615j0z 5 19 and and CCONJ 5712m615j0z 5 20 concludes conclude VERB 5712m615j0z 5 21 that that SCONJ 5712m615j0z 5 22 enthalpy enthalpy NOUN 5712m615j0z 5 23 - - PUNCT 5712m615j0z 5 24 entropy entropy NOUN 5712m615j0z 5 25 compensation compensation NOUN 5712m615j0z 5 26 effects effect NOUN 5712m615j0z 5 27 make make VERB 5712m615j0z 5 28 it it PRON 5712m615j0z 5 29 very very ADV 5712m615j0z 5 30 difficult difficult ADJ 5712m615j0z 5 31 to to PART 5712m615j0z 5 32 rationally rationally ADV 5712m615j0z 5 33 design design VERB 5712m615j0z 5 34 small small ADJ 5712m615j0z 5 35 molecule molecule NOUN 5712m615j0z 5 36 synthetic synthetic ADJ 5712m615j0z 5 37 receptors receptor NOUN 5712m615j0z 5 38 . . PUNCT 5712m615j0z 6 1 chapter chapter NOUN 5712m615j0z 6 2 2 2 NUM 5712m615j0z 6 3 focuses focus VERB 5712m615j0z 6 4 on on ADP 5712m615j0z 6 5 the the DET 5712m615j0z 6 6 development development NOUN 5712m615j0z 6 7 of of ADP 5712m615j0z 6 8 next next ADJ 5712m615j0z 6 9 - - PUNCT 5712m615j0z 6 10 generation generation NOUN 5712m615j0z 6 11 zn zn X 5712m615j0z 6 12 - - PUNCT 5712m615j0z 6 13 bdpa bdpa ADJ 5712m615j0z 6 14 coordination coordination NOUN 5712m615j0z 6 15 complexes complex NOUN 5712m615j0z 6 16 for for ADP 5712m615j0z 6 17 enhanced enhanced ADJ 5712m615j0z 6 18 recognition recognition NOUN 5712m615j0z 6 19 of of ADP 5712m615j0z 6 20 ps ps PROPN 5712m615j0z 6 21 . . PUNCT 5712m615j0z 7 1 the the DET 5712m615j0z 7 2 tangible tangible ADJ 5712m615j0z 7 3 outcome outcome NOUN 5712m615j0z 7 4 of of ADP 5712m615j0z 7 5 this this DET 5712m615j0z 7 6 chapter chapter NOUN 5712m615j0z 7 7 is be AUX 5712m615j0z 7 8 disclosure disclosure NOUN 5712m615j0z 7 9 of of ADP 5712m615j0z 7 10 a a DET 5712m615j0z 7 11 next next ADJ 5712m615j0z 7 12 generation generation NOUN 5712m615j0z 7 13 , , PUNCT 5712m615j0z 7 14 deep deep ADJ 5712m615j0z 7 15 - - PUNCT 5712m615j0z 7 16 red red ADJ 5712m615j0z 7 17 fluorescent fluorescent NOUN 5712m615j0z 7 18 zn zn PROPN 5712m615j0z 7 19 - - PUNCT 5712m615j0z 7 20 bdpa bdpa ADJ 5712m615j0z 7 21 probe probe NOUN 5712m615j0z 7 22 for for ADP 5712m615j0z 7 23 enhanced enhanced ADJ 5712m615j0z 7 24 molecular molecular ADJ 5712m615j0z 7 25 imaging imaging NOUN 5712m615j0z 7 26 of of ADP 5712m615j0z 7 27 cell cell NOUN 5712m615j0z 7 28 death death NOUN 5712m615j0z 7 29 . . PUNCT 5712m615j0z 8 1 chapter chapter NOUN 5712m615j0z 8 2 3 3 NUM 5712m615j0z 8 3 documents document NOUN 5712m615j0z 8 4 efforts effort NOUN 5712m615j0z 8 5 to to PART 5712m615j0z 8 6 improve improve VERB 5712m615j0z 8 7 the the DET 5712m615j0z 8 8 eventual eventual ADJ 5712m615j0z 8 9 clinical clinical ADJ 5712m615j0z 8 10 translation translation NOUN 5712m615j0z 8 11 of of ADP 5712m615j0z 8 12 these these DET 5712m615j0z 8 13 zn zn NOUN 5712m615j0z 8 14 - - PUNCT 5712m615j0z 8 15 bdpa bdpa ADJ 5712m615j0z 8 16 probes probe NOUN 5712m615j0z 8 17 through through ADP 5712m615j0z 8 18 the the DET 5712m615j0z 8 19 development development NOUN 5712m615j0z 8 20 of of ADP 5712m615j0z 8 21 a a DET 5712m615j0z 8 22 water water NOUN 5712m615j0z 8 23 soluble soluble ADJ 5712m615j0z 8 24 micelle micelle ADJ 5712m615j0z 8 25 formulation formulation NOUN 5712m615j0z 8 26 and and CCONJ 5712m615j0z 8 27 conjugation conjugation NOUN 5712m615j0z 8 28 to to ADP 5712m615j0z 8 29 clinically clinically ADV 5712m615j0z 8 30 relevant relevant ADJ 5712m615j0z 8 31 reporter reporter NOUN 5712m615j0z 8 32 group group NOUN 5712m615j0z 8 33 elements element NOUN 5712m615j0z 8 34 for for ADP 5712m615j0z 8 35 use use NOUN 5712m615j0z 8 36 in in ADP 5712m615j0z 8 37 mri mri NOUN 5712m615j0z 8 38 and and CCONJ 5712m615j0z 8 39 spect spect VERB 5712m615j0z 8 40 imaging imaging NOUN 5712m615j0z 8 41 applications application NOUN 5712m615j0z 8 42 . . PUNCT 5712m615j0z 9 1 as as ADP 5712m615j0z 9 2 a a DET 5712m615j0z 9 3 spin spin NOUN 5712m615j0z 9 4 - - PUNCT 5712m615j0z 9 5 off off NOUN 5712m615j0z 9 6 of of ADP 5712m615j0z 9 7 mri mri NOUN 5712m615j0z 9 8 imaging imaging NOUN 5712m615j0z 9 9 probes probe VERB 5712m615j0z 9 10 a a DET 5712m615j0z 9 11 19f 19f NOUN 5712m615j0z 9 12 nmr nmr PROPN 5712m615j0z 9 13 indicator indicator NOUN 5712m615j0z 9 14 displacement displacement PROPN 5712m615j0z 9 15 assay assay PROPN 5712m615j0z 9 16 using use VERB 5712m615j0z 9 17 a a DET 5712m615j0z 9 18 19f 19f NOUN 5712m615j0z 9 19 labelled label VERB 5712m615j0z 9 20 phosphate phosphate ADJ 5712m615j0z 9 21 indicator indicator NOUN 5712m615j0z 9 22 and and CCONJ 5712m615j0z 9 23 zn zn X 5712m615j0z 9 24 - - PUNCT 5712m615j0z 9 25 bdpa bdpa VERB 5712m615j0z 9 26 nuclear nuclear ADJ 5712m615j0z 9 27 relaxation relaxation NOUN 5712m615j0z 9 28 agents agent NOUN 5712m615j0z 9 29 is be AUX 5712m615j0z 9 30 discussed discuss VERB 5712m615j0z 9 31 in in ADP 5712m615j0z 9 32 chapter chapter NOUN 5712m615j0z 9 33 5 5 NUM 5712m615j0z 9 34 . . PUNCT 5712m615j0z 10 1 in in ADP 5712m615j0z 10 2 chapter chapter NOUN 5712m615j0z 10 3 4 4 NUM 5712m615j0z 10 4 the the DET 5712m615j0z 10 5 ability ability NOUN 5712m615j0z 10 6 of of ADP 5712m615j0z 10 7 zn zn X 5712m615j0z 10 8 - - PUNCT 5712m615j0z 10 9 bdpa bdpa ADJ 5712m615j0z 10 10 affinity affinity NOUN 5712m615j0z 10 11 ligands ligand NOUN 5712m615j0z 10 12 to to PART 5712m615j0z 10 13 recognize recognize VERB 5712m615j0z 10 14 ps ps PROPN 5712m615j0z 10 15 is be AUX 5712m615j0z 10 16 exploited exploit VERB 5712m615j0z 10 17 through through ADP 5712m615j0z 10 18 the the DET 5712m615j0z 10 19 development development NOUN 5712m615j0z 10 20 of of ADP 5712m615j0z 10 21 a a DET 5712m615j0z 10 22 chemically chemically ADV 5712m615j0z 10 23 triggered trigger VERB 5712m615j0z 10 24 liposomal liposomal ADJ 5712m615j0z 10 25 drug drug NOUN 5712m615j0z 10 26 delivery delivery NOUN 5712m615j0z 10 27 system system NOUN 5712m615j0z 10 28 . . PUNCT 5712m615j0z 11 1 selective selective ADJ 5712m615j0z 11 2 release release NOUN 5712m615j0z 11 3 of of ADP 5712m615j0z 11 4 contents content NOUN 5712m615j0z 11 5 from from ADP 5712m615j0z 11 6 liposomes liposome NOUN 5712m615j0z 11 7 is be AUX 5712m615j0z 11 8 induced induce VERB 5712m615j0z 11 9 using use VERB 5712m615j0z 11 10 a a DET 5712m615j0z 11 11 non non ADJ 5712m615j0z 11 12 - - ADJ 5712m615j0z 11 13 toxic toxic ADJ 5712m615j0z 11 14 zn zn NOUN 5712m615j0z 11 15 - - PUNCT 5712m615j0z 11 16 bdpa bdpa VERB 5712m615j0z 11 17 chemical chemical NOUN 5712m615j0z 11 18 trigger trigger NOUN 5712m615j0z 11 19 that that PRON 5712m615j0z 11 20 associates associate VERB 5712m615j0z 11 21 with with ADP 5712m615j0z 11 22 a a DET 5712m615j0z 11 23 ps ps NOUN 5712m615j0z 11 24 targeting target VERB 5712m615j0z 11 25 molecule molecule NOUN 5712m615j0z 11 26 embedded embed VERB 5712m615j0z 11 27 in in ADP 5712m615j0z 11 28 the the DET 5712m615j0z 11 29 liposome liposome NOUN 5712m615j0z 11 30 surface surface NOUN 5712m615j0z 11 31 and and CCONJ 5712m615j0z 11 32 causes cause VERB 5712m615j0z 11 33 membrane membrane NOUN 5712m615j0z 11 34 disruption disruption NOUN 5712m615j0z 11 35 . . PUNCT