id sid tid token lemma pos 4x51hh65r31 1 1 nucleoside nucleoside NOUN 4x51hh65r31 1 2 reverse reverse NOUN 4x51hh65r31 1 3 transcriptase transcriptase NOUN 4x51hh65r31 1 4 inhibitors inhibitor NOUN 4x51hh65r31 1 5 ( ( PUNCT 4x51hh65r31 1 6 nrtis nrtis NOUN 4x51hh65r31 1 7 ) ) PUNCT 4x51hh65r31 1 8 have have AUX 4x51hh65r31 1 9 been be AUX 4x51hh65r31 1 10 used use VERB 4x51hh65r31 1 11 for for ADP 4x51hh65r31 1 12 the the DET 4x51hh65r31 1 13 last last ADJ 4x51hh65r31 1 14 20 20 NUM 4x51hh65r31 1 15 years year NOUN 4x51hh65r31 1 16 to to PART 4x51hh65r31 1 17 fight fight VERB 4x51hh65r31 1 18 the the DET 4x51hh65r31 1 19 progression progression NOUN 4x51hh65r31 1 20 of of ADP 4x51hh65r31 1 21 the the DET 4x51hh65r31 1 22 human human ADJ 4x51hh65r31 1 23 immune immune ADJ 4x51hh65r31 1 24 deficiency deficiency NOUN 4x51hh65r31 1 25 virus virus NOUN 4x51hh65r31 1 26 , , PUNCT 4x51hh65r31 1 27 the the DET 4x51hh65r31 1 28 virus virus NOUN 4x51hh65r31 1 29 that that PRON 4x51hh65r31 1 30 causes cause VERB 4x51hh65r31 1 31 aids aid NOUN 4x51hh65r31 1 32 . . PUNCT 4x51hh65r31 2 1 however however ADV 4x51hh65r31 2 2 nrti nrti PROPN 4x51hh65r31 2 3 antiviral antiviral ADJ 4x51hh65r31 2 4 treatments treatment NOUN 4x51hh65r31 2 5 are be AUX 4x51hh65r31 2 6 associated associate VERB 4x51hh65r31 2 7 with with ADP 4x51hh65r31 2 8 tissue tissue NOUN 4x51hh65r31 2 9 toxicities toxicity NOUN 4x51hh65r31 2 10 that that PRON 4x51hh65r31 2 11 target target VERB 4x51hh65r31 2 12 the the DET 4x51hh65r31 2 13 mitochondria mitochondria NOUN 4x51hh65r31 2 14 , , PUNCT 4x51hh65r31 2 15 decreasing decrease VERB 4x51hh65r31 2 16 mitochondrial mitochondrial ADJ 4x51hh65r31 2 17 dna dna NOUN 4x51hh65r31 2 18 replication replication NOUN 4x51hh65r31 2 19 . . PUNCT 4x51hh65r31 3 1 toxicities toxicity NOUN 4x51hh65r31 3 2 associated associate VERB 4x51hh65r31 3 3 with with ADP 4x51hh65r31 3 4 nrtis nrtis PROPN 4x51hh65r31 3 5 display display NOUN 4x51hh65r31 3 6 significant significant ADJ 4x51hh65r31 3 7 tissue tissue NOUN 4x51hh65r31 3 8 variability variability NOUN 4x51hh65r31 3 9 with with ADP 4x51hh65r31 3 10 each each DET 4x51hh65r31 3 11 nrti nrti NOUN 4x51hh65r31 3 12 preferentially preferentially ADV 4x51hh65r31 3 13 affecting affect VERB 4x51hh65r31 3 14 certain certain ADJ 4x51hh65r31 3 15 tissues tissue NOUN 4x51hh65r31 3 16 . . PUNCT 4x51hh65r31 4 1 the the DET 4x51hh65r31 4 2 mechanisms mechanism NOUN 4x51hh65r31 4 3 accounting account VERB 4x51hh65r31 4 4 for for ADP 4x51hh65r31 4 5 this this DET 4x51hh65r31 4 6 tissue tissue NOUN 4x51hh65r31 4 7 specificity specificity NOUN 4x51hh65r31 4 8 of of ADP 4x51hh65r31 4 9 toxicity toxicity NOUN 4x51hh65r31 4 10 is be AUX 4x51hh65r31 4 11 unknown unknown ADJ 4x51hh65r31 4 12 . . PUNCT 4x51hh65r31 5 1 in in ADP 4x51hh65r31 5 2 previous previous ADJ 4x51hh65r31 5 3 studies study NOUN 4x51hh65r31 5 4 from from ADP 4x51hh65r31 5 5 this this DET 4x51hh65r31 5 6 laboratory laboratory NOUN 4x51hh65r31 5 7 , , PUNCT 4x51hh65r31 5 8 the the DET 4x51hh65r31 5 9 effects effect NOUN 4x51hh65r31 5 10 of of ADP 4x51hh65r31 5 11 nrtis nrtis PROPN 4x51hh65r31 5 12 have have AUX 4x51hh65r31 5 13 been be AUX 4x51hh65r31 5 14 investigated investigate VERB 4x51hh65r31 5 15 on on ADP 4x51hh65r31 5 16 liver liver NOUN 4x51hh65r31 5 17 and and CCONJ 4x51hh65r31 5 18 heart heart NOUN 4x51hh65r31 5 19 mitochondria mitochondria PROPN 4x51hh65r31 5 20 , , PUNCT 4x51hh65r31 5 21 tissues tissue NOUN 4x51hh65r31 5 22 that that PRON 4x51hh65r31 5 23 are be AUX 4x51hh65r31 5 24 associated associate VERB 4x51hh65r31 5 25 with with ADP 4x51hh65r31 5 26 known know VERB 4x51hh65r31 5 27 nrti nrti NOUN 4x51hh65r31 5 28 toxicities toxicity NOUN 4x51hh65r31 5 29 . . PUNCT 4x51hh65r31 6 1 the the DET 4x51hh65r31 6 2 goal goal NOUN 4x51hh65r31 6 3 of of ADP 4x51hh65r31 6 4 the the DET 4x51hh65r31 6 5 project project NOUN 4x51hh65r31 6 6 presented present VERB 4x51hh65r31 6 7 here here ADV 4x51hh65r31 6 8 is be AUX 4x51hh65r31 6 9 to to PART 4x51hh65r31 6 10 expand expand VERB 4x51hh65r31 6 11 these these DET 4x51hh65r31 6 12 studies study NOUN 4x51hh65r31 6 13 to to ADP 4x51hh65r31 6 14 brain brain NOUN 4x51hh65r31 6 15 mitochondria mitochondria PROPN 4x51hh65r31 6 16 , , PUNCT 4x51hh65r31 6 17 a a DET 4x51hh65r31 6 18 tissue tissue NOUN 4x51hh65r31 6 19 relatively relatively ADV 4x51hh65r31 6 20 resistant resistant ADJ 4x51hh65r31 6 21 to to PART 4x51hh65r31 6 22 nrti nrti NOUN 4x51hh65r31 6 23 toxicity toxicity NOUN 4x51hh65r31 6 24 . . PUNCT 4x51hh65r31 7 1 this this DET 4x51hh65r31 7 2 project project NOUN 4x51hh65r31 7 3 has have AUX 4x51hh65r31 7 4 investigated investigate VERB 4x51hh65r31 7 5 the the DET 4x51hh65r31 7 6 ability ability NOUN 4x51hh65r31 7 7 of of ADP 4x51hh65r31 7 8 brain brain NOUN 4x51hh65r31 7 9 mitochondria mitochondria NOUN 4x51hh65r31 7 10 to to PART 4x51hh65r31 7 11 phosphorylate phosphorylate VERB 4x51hh65r31 7 12 deoxynucleosides deoxynucleoside NOUN 4x51hh65r31 7 13 and and CCONJ 4x51hh65r31 7 14 their their PRON 4x51hh65r31 7 15 analogs analog NOUN 4x51hh65r31 7 16 , , PUNCT 4x51hh65r31 7 17 and and CCONJ 4x51hh65r31 7 18 to to PART 4x51hh65r31 7 19 determine determine VERB 4x51hh65r31 7 20 if if SCONJ 4x51hh65r31 7 21 any any PRON 4x51hh65r31 7 22 of of ADP 4x51hh65r31 7 23 the the DET 4x51hh65r31 7 24 nrtis nrtis PROPN 4x51hh65r31 7 25 have have VERB 4x51hh65r31 7 26 adverse adverse ADJ 4x51hh65r31 7 27 effects effect NOUN 4x51hh65r31 7 28 on on ADP 4x51hh65r31 7 29 the the DET 4x51hh65r31 7 30 phosphorylation phosphorylation NOUN 4x51hh65r31 7 31 of of ADP 4x51hh65r31 7 32 naturally naturally ADV 4x51hh65r31 7 33 occurring occur VERB 4x51hh65r31 7 34 deoxynucleosides deoxynucleoside NOUN 4x51hh65r31 7 35 . . PUNCT 4x51hh65r31 8 1 high high ADJ 4x51hh65r31 8 2 quality quality NOUN 4x51hh65r31 8 3 mitochondria mitochondria NOUN 4x51hh65r31 8 4 were be AUX 4x51hh65r31 8 5 isolated isolate VERB 4x51hh65r31 8 6 from from ADP 4x51hh65r31 8 7 harlan harlan PROPN 4x51hh65r31 8 8 sprague sprague PROPN 4x51hh65r31 8 9 dawley dawley PROPN 4x51hh65r31 8 10 rat rat NOUN 4x51hh65r31 8 11 brains brain NOUN 4x51hh65r31 8 12 and and CCONJ 4x51hh65r31 8 13 were be AUX 4x51hh65r31 8 14 incubated incubate VERB 4x51hh65r31 8 15 in in ADP 4x51hh65r31 8 16 media medium NOUN 4x51hh65r31 8 17 with with ADP 4x51hh65r31 8 18 labeled label VERB 4x51hh65r31 8 19 deoxynucleoside deoxynucleoside NOUN 4x51hh65r31 8 20 or or CCONJ 4x51hh65r31 8 21 labeled label VERB 4x51hh65r31 8 22 nrti nrti PROPN 4x51hh65r31 8 23 to to PART 4x51hh65r31 8 24 determine determine VERB 4x51hh65r31 8 25 the the DET 4x51hh65r31 8 26 rate rate NOUN 4x51hh65r31 8 27 and and CCONJ 4x51hh65r31 8 28 extent extent NOUN 4x51hh65r31 8 29 of of ADP 4x51hh65r31 8 30 phosphorylation phosphorylation NOUN 4x51hh65r31 8 31 of of ADP 4x51hh65r31 8 32 the the DET 4x51hh65r31 8 33 deoxynucleoside deoxynucleoside NOUN 4x51hh65r31 8 34 or or CCONJ 4x51hh65r31 8 35 analog analog NOUN 4x51hh65r31 8 36 . . PUNCT 4x51hh65r31 9 1 in in ADP 4x51hh65r31 9 2 addition addition NOUN 4x51hh65r31 9 3 , , PUNCT 4x51hh65r31 9 4 the the DET 4x51hh65r31 9 5 effects effect NOUN 4x51hh65r31 9 6 of of ADP 4x51hh65r31 9 7 various various ADJ 4x51hh65r31 9 8 nrtis nrtis NOUN 4x51hh65r31 9 9 on on ADP 4x51hh65r31 9 10 rates rate NOUN 4x51hh65r31 9 11 of of ADP 4x51hh65r31 9 12 phosphorylation phosphorylation NOUN 4x51hh65r31 9 13 of of ADP 4x51hh65r31 9 14 their their PRON 4x51hh65r31 9 15 corresponding corresponding ADJ 4x51hh65r31 9 16 deoxynucleosides deoxynucleoside NOUN 4x51hh65r31 9 17 were be AUX 4x51hh65r31 9 18 investigated investigate VERB 4x51hh65r31 9 19 . . PUNCT 4x51hh65r31 10 1 all all DET 4x51hh65r31 10 2 results result NOUN 4x51hh65r31 10 3 were be AUX 4x51hh65r31 10 4 analyzed analyze VERB 4x51hh65r31 10 5 by by ADP 4x51hh65r31 10 6 hplc hplc NOUN 4x51hh65r31 10 7 and and CCONJ 4x51hh65r31 10 8 an an DET 4x51hh65r31 10 9 in in ADP 4x51hh65r31 10 10 - - PUNCT 4x51hh65r31 10 11 line line NOUN 4x51hh65r31 10 12 scintillation scintillation NOUN 4x51hh65r31 10 13 counter counter NOUN 4x51hh65r31 10 14 . . PUNCT 4x51hh65r31 11 1 results result NOUN 4x51hh65r31 11 2 demonstrate demonstrate VERB 4x51hh65r31 11 3 that that SCONJ 4x51hh65r31 11 4 the the DET 4x51hh65r31 11 5 mitochondrial mitochondrial ADJ 4x51hh65r31 11 6 deoxynucleoside deoxynucleoside NOUN 4x51hh65r31 11 7 salvage salvage NOUN 4x51hh65r31 11 8 pathways pathway NOUN 4x51hh65r31 11 9 are be AUX 4x51hh65r31 11 10 more more ADV 4x51hh65r31 11 11 active active ADJ 4x51hh65r31 11 12 in in ADP 4x51hh65r31 11 13 brain brain NOUN 4x51hh65r31 11 14 mitochondria mitochondria NOUN 4x51hh65r31 11 15 than than ADP 4x51hh65r31 11 16 in in ADP 4x51hh65r31 11 17 heart heart NOUN 4x51hh65r31 11 18 or or CCONJ 4x51hh65r31 11 19 liver liver NOUN 4x51hh65r31 11 20 mitochondria mitochondria PROPN 4x51hh65r31 11 21 . . PUNCT 4x51hh65r31 12 1 present present ADJ 4x51hh65r31 12 2 data datum NOUN 4x51hh65r31 12 3 show show VERB 4x51hh65r31 12 4 a a DET 4x51hh65r31 12 5 dramatic dramatic ADJ 4x51hh65r31 12 6 increase increase NOUN 4x51hh65r31 12 7 in in ADP 4x51hh65r31 12 8 the the DET 4x51hh65r31 12 9 rate rate NOUN 4x51hh65r31 12 10 of of ADP 4x51hh65r31 12 11 phosphorylation phosphorylation NOUN 4x51hh65r31 12 12 of of ADP 4x51hh65r31 12 13 thymidine thymidine NOUN 4x51hh65r31 12 14 ( ( PUNCT 4x51hh65r31 12 15 140 140 NUM 4x51hh65r31 12 16 pmol pmol NOUN 4x51hh65r31 12 17 / / SYM 4x51hh65r31 12 18 mg mg NOUN 4x51hh65r31 12 19 ) ) PUNCT 4x51hh65r31 12 20 and and CCONJ 4x51hh65r31 12 21 azt azt PROPN 4x51hh65r31 12 22 ( ( PUNCT 4x51hh65r31 12 23 140 140 NUM 4x51hh65r31 12 24 pmol pmol NOUN 4x51hh65r31 12 25 / / SYM 4x51hh65r31 12 26 mg mg NOUN 4x51hh65r31 12 27 ) ) PUNCT 4x51hh65r31 12 28 individually individually ADV 4x51hh65r31 12 29 in in ADP 4x51hh65r31 12 30 brain brain NOUN 4x51hh65r31 12 31 mitochondria mitochondria NOUN 4x51hh65r31 12 32 compared compare VERB 4x51hh65r31 12 33 to to ADP 4x51hh65r31 12 34 mitochondria mitochondria NOUN 4x51hh65r31 12 35 from from ADP 4x51hh65r31 12 36 heart heart NOUN 4x51hh65r31 12 37 ( ( PUNCT 4x51hh65r31 12 38 20 20 NUM 4x51hh65r31 12 39 pmols pmol NOUN 4x51hh65r31 12 40 / / SYM 4x51hh65r31 12 41 mg mg PROPN 4x51hh65r31 12 42 and and CCONJ 4x51hh65r31 12 43 6 6 NUM 4x51hh65r31 12 44 pmol pmol NOUN 4x51hh65r31 12 45 / / SYM 4x51hh65r31 12 46 mg mg NOUN 4x51hh65r31 12 47 ) ) PUNCT 4x51hh65r31 12 48 and and CCONJ 4x51hh65r31 12 49 liver liver NOUN 4x51hh65r31 12 50 ( ( PUNCT 4x51hh65r31 12 51 40 40 NUM 4x51hh65r31 12 52 pmol pmol NOUN 4x51hh65r31 12 53 / / SYM 4x51hh65r31 12 54 mg mg NOUN 4x51hh65r31 12 55 and and CCONJ 4x51hh65r31 12 56 9 9 NUM 4x51hh65r31 12 57 pmol pmol NOUN 4x51hh65r31 12 58 / / SYM 4x51hh65r31 12 59 mg mg NOUN 4x51hh65r31 12 60 ) ) PUNCT 4x51hh65r31 12 61 after after ADP 4x51hh65r31 12 62 90 90 NUM 4x51hh65r31 12 63 minute minute NOUN 4x51hh65r31 12 64 incubations incubation NOUN 4x51hh65r31 12 65 . . PUNCT 4x51hh65r31 13 1 phosphorylation phosphorylation NOUN 4x51hh65r31 13 2 of of ADP 4x51hh65r31 13 3 deoxycytidine deoxycytidine NOUN 4x51hh65r31 13 4 is be AUX 4x51hh65r31 13 5 also also ADV 4x51hh65r31 13 6 very very ADV 4x51hh65r31 13 7 active active ADJ 4x51hh65r31 13 8 with with ADP 4x51hh65r31 13 9 210 210 NUM 4x51hh65r31 13 10 pmol pmol NOUN 4x51hh65r31 13 11 / / SYM 4x51hh65r31 13 12 mg mg NOUN 4x51hh65r31 13 13 phosphorylated phosphorylate VERB 4x51hh65r31 13 14 after after ADP 4x51hh65r31 13 15 180 180 NUM 4x51hh65r31 13 16 minutes minute NOUN 4x51hh65r31 13 17 . . PUNCT 4x51hh65r31 14 1 deoxyuridine deoxyuridine PROPN 4x51hh65r31 14 2 is be AUX 4x51hh65r31 14 3 phosphorylated phosphorylate VERB 4x51hh65r31 14 4 to to ADP 4x51hh65r31 14 5 the the DET 4x51hh65r31 14 6 monophosphate monophosphate ADJ 4x51hh65r31 14 7 form form NOUN 4x51hh65r31 14 8 in in ADP 4x51hh65r31 14 9 brain brain NOUN 4x51hh65r31 14 10 mitochondria mitochondria NOUN 4x51hh65r31 14 11 which which PRON 4x51hh65r31 14 12 has have AUX 4x51hh65r31 14 13 also also ADV 4x51hh65r31 14 14 been be AUX 4x51hh65r31 14 15 shown show VERB 4x51hh65r31 14 16 in in ADP 4x51hh65r31 14 17 heart heart NOUN 4x51hh65r31 14 18 mitochondria mitochondria NOUN 4x51hh65r31 14 19 , , PUNCT 4x51hh65r31 14 20 but but CCONJ 4x51hh65r31 14 21 not not PART 4x51hh65r31 14 22 in in ADP 4x51hh65r31 14 23 perfused perfused ADJ 4x51hh65r31 14 24 heart heart NOUN 4x51hh65r31 14 25 . . PUNCT 4x51hh65r31 15 1 data datum NOUN 4x51hh65r31 15 2 demonstrate demonstrate VERB 4x51hh65r31 15 3 that that SCONJ 4x51hh65r31 15 4 azt azt PROPN 4x51hh65r31 15 5 is be AUX 4x51hh65r31 15 6 a a DET 4x51hh65r31 15 7 potent potent ADJ 4x51hh65r31 15 8 inhibitor inhibitor NOUN 4x51hh65r31 15 9 of of ADP 4x51hh65r31 15 10 thymidine thymidine NOUN 4x51hh65r31 15 11 phosphorylation phosphorylation NOUN 4x51hh65r31 15 12 in in ADP 4x51hh65r31 15 13 brain brain NOUN 4x51hh65r31 15 14 mitochondria mitochondria NOUN 4x51hh65r31 15 15 with with ADP 4x51hh65r31 15 16 an an DET 4x51hh65r31 15 17 ic50 ic50 PROPN 4x51hh65r31 15 18 of of ADP 4x51hh65r31 15 19 5.5 5.5 NUM