id	sid	tid	token	lemma	pos
4q77fq9958t	1	1	the	the	DET
4q77fq9958t	1	2	pursuit	pursuit	NOUN
4q77fq9958t	1	3	of	of	ADP
4q77fq9958t	1	4	biologically	biologically	ADV
4q77fq9958t	1	5	active	active	ADJ
4q77fq9958t	1	6	natural	natural	ADJ
4q77fq9958t	1	7	products	product	NOUN
4q77fq9958t	1	8	affords	afford	VERB
4q77fq9958t	1	9	numerous	numerous	ADJ
4q77fq9958t	1	10	avenues	avenue	NOUN
4q77fq9958t	1	11	of	of	ADP
4q77fq9958t	1	12	study	study	NOUN
4q77fq9958t	1	13	,	,	PUNCT
4q77fq9958t	1	14	all	all	PRON
4q77fq9958t	1	15	of	of	ADP
4q77fq9958t	1	16	which	which	PRON
4q77fq9958t	1	17	strive	strive	VERB
4q77fq9958t	1	18	for	for	ADP
4q77fq9958t	1	19	a	a	DET
4q77fq9958t	1	20	common	common	ADJ
4q77fq9958t	1	21	goal	goal	NOUN
4q77fq9958t	1	22	:	:	PUNCT
4q77fq9958t	1	23	enhancing	enhance	VERB
4q77fq9958t	1	24	activity	activity	NOUN
4q77fq9958t	1	25	of	of	ADP
4q77fq9958t	1	26	and	and	CCONJ
4q77fq9958t	1	27	access	access	NOUN
4q77fq9958t	1	28	to	to	ADP
4q77fq9958t	1	29	potential	potential	ADJ
4q77fq9958t	1	30	lead	lead	NOUN
4q77fq9958t	1	31	compounds	compound	NOUN
4q77fq9958t	1	32	of	of	ADP
4q77fq9958t	1	33	therapeutic	therapeutic	ADJ
4q77fq9958t	1	34	interest	interest	NOUN
4q77fq9958t	1	35	.	.	PUNCT
4q77fq9958t	2	1	the	the	DET
4q77fq9958t	2	2	systems	system	NOUN
4q77fq9958t	2	3	of	of	ADP
4q77fq9958t	2	4	particular	particular	ADJ
4q77fq9958t	2	5	interest	interest	NOUN
4q77fq9958t	2	6	to	to	ADP
4q77fq9958t	2	7	this	this	DET
4q77fq9958t	2	8	research	research	NOUN
4q77fq9958t	2	9	are	be	AUX
4q77fq9958t	2	10	polyketides	polyketide	NOUN
4q77fq9958t	2	11	synthase	synthase	NOUN
4q77fq9958t	2	12	derived	derive	VERB
4q77fq9958t	2	13	natural	natural	ADJ
4q77fq9958t	2	14	products	product	NOUN
4q77fq9958t	2	15	and	and	CCONJ
4q77fq9958t	2	16	,	,	PUNCT
4q77fq9958t	2	17	in	in	ADP
4q77fq9958t	2	18	particular	particular	ADJ
4q77fq9958t	2	19	,	,	PUNCT
4q77fq9958t	2	20	the	the	DET
4q77fq9958t	2	21	epothilones	epothilone	NOUN
4q77fq9958t	2	22	and	and	CCONJ
4q77fq9958t	2	23	peloruside	peloruside	PROPN
4q77fq9958t	2	24	a.	a.	PROPN
4q77fq9958t	2	25	toward	toward	ADP
4q77fq9958t	2	26	the	the	DET
4q77fq9958t	2	27	design	design	NOUN
4q77fq9958t	2	28	of	of	ADP
4q77fq9958t	2	29	novel	novel	ADJ
4q77fq9958t	2	30	methodologies	methodology	NOUN
4q77fq9958t	2	31	,	,	PUNCT
4q77fq9958t	2	32	this	this	DET
4q77fq9958t	2	33	project	project	NOUN
4q77fq9958t	2	34	has	have	AUX
4q77fq9958t	2	35	focused	focus	VERB
4q77fq9958t	2	36	on	on	ADP
4q77fq9958t	2	37	development	development	NOUN
4q77fq9958t	2	38	of	of	ADP
4q77fq9958t	2	39	1,3	1,3	PROPN
4q77fq9958t	2	40	-	-	PUNCT
4q77fq9958t	2	41	diols	diol	NOUN
4q77fq9958t	2	42	and	and	CCONJ
4q77fq9958t	2	43	their	their	PRON
4q77fq9958t	2	44	related	related	ADJ
4q77fq9958t	2	45	monoethers	monoether	NOUN
4q77fq9958t	2	46	with	with	ADP
4q77fq9958t	2	47	high	high	ADJ
4q77fq9958t	2	48	diastereoselectivity	diastereoselectivity	NOUN
4q77fq9958t	2	49	.	.	PUNCT
4q77fq9958t	3	1	the	the	DET
4q77fq9958t	3	2	method	method	NOUN
4q77fq9958t	3	3	has	have	AUX
4q77fq9958t	3	4	focused	focus	VERB
4q77fq9958t	3	5	on	on	ADP
4q77fq9958t	3	6	the	the	DET
4q77fq9958t	3	7	intramolecular	intramolecular	ADJ
4q77fq9958t	3	8	delivery	delivery	NOUN
4q77fq9958t	3	9	of	of	ADP
4q77fq9958t	3	10	an	an	DET
4q77fq9958t	3	11	oxygen	oxygen	NOUN
4q77fq9958t	3	12	nucleophile	nucleophile	NOUN
4q77fq9958t	3	13	in	in	ADP
4q77fq9958t	3	14	the	the	DET
4q77fq9958t	3	15	form	form	NOUN
4q77fq9958t	3	16	of	of	ADP
4q77fq9958t	3	17	a	a	DET
4q77fq9958t	3	18	methyl	methyl	NOUN
4q77fq9958t	3	19	ether	ether	NOUN
4q77fq9958t	3	20	.	.	PUNCT
4q77fq9958t	4	1	the	the	DET
4q77fq9958t	4	2	delivery	delivery	NOUN
4q77fq9958t	4	3	of	of	ADP
4q77fq9958t	4	4	the	the	DET
4q77fq9958t	4	5	oxygen	oxygen	NOUN
4q77fq9958t	4	6	atom	atom	NOUN
4q77fq9958t	4	7	to	to	ADP
4q77fq9958t	4	8	a	a	DET
4q77fq9958t	4	9	carbocation	carbocation	NOUN
4q77fq9958t	4	10	via	via	ADP
4q77fq9958t	4	11	multiple	multiple	ADJ
4q77fq9958t	4	12	activation	activation	NOUN
4q77fq9958t	4	13	schemes	scheme	NOUN
4q77fq9958t	4	14	was	be	AUX
4q77fq9958t	4	15	explored	explore	VERB
4q77fq9958t	4	16	,	,	PUNCT
4q77fq9958t	4	17	with	with	ADP
4q77fq9958t	4	18	both	both	DET
4q77fq9958t	4	19	iodide	iodide	NOUN
4q77fq9958t	4	20	activation	activation	NOUN
4q77fq9958t	4	21	and	and	CCONJ
4q77fq9958t	4	22	alcohol	alcohol	NOUN
4q77fq9958t	4	23	triflation	triflation	NOUN
4q77fq9958t	4	24	providing	provide	VERB
4q77fq9958t	4	25	the	the	DET
4q77fq9958t	4	26	desired	desire	VERB
4q77fq9958t	4	27	diol	diol	NOUN
4q77fq9958t	4	28	-	-	PUNCT
4q77fq9958t	4	29	monoether	monoether	NOUN
4q77fq9958t	4	30	in	in	ADP
4q77fq9958t	4	31	high	high	ADJ
4q77fq9958t	4	32	yield	yield	NOUN
4q77fq9958t	4	33	and	and	CCONJ
4q77fq9958t	4	34	with	with	ADP
4q77fq9958t	4	35	high	high	ADJ
4q77fq9958t	4	36	diastereoselectivity	diastereoselectivity	NOUN
4q77fq9958t	4	37	.	.	PUNCT
4q77fq9958t	5	1	the	the	DET
4q77fq9958t	5	2	delivered	delivered	ADJ
4q77fq9958t	5	3	oxygen	oxygen	NOUN
4q77fq9958t	5	4	nucleophile	nucleophile	NOUN
4q77fq9958t	5	5	has	have	AUX
4q77fq9958t	5	6	also	also	ADV
4q77fq9958t	5	7	been	be	AUX
4q77fq9958t	5	8	demonstrated	demonstrate	VERB
4q77fq9958t	5	9	to	to	PART
4q77fq9958t	5	10	be	be	AUX
4q77fq9958t	5	11	synthetically	synthetically	ADV
4q77fq9958t	5	12	variable	variable	ADJ
4q77fq9958t	5	13	,	,	PUNCT
4q77fq9958t	5	14	affording	afford	VERB
4q77fq9958t	5	15	both	both	CCONJ
4q77fq9958t	5	16	stable	stable	ADJ
4q77fq9958t	5	17	and	and	CCONJ
4q77fq9958t	5	18	labile	labile	ADJ
4q77fq9958t	5	19	ether	ether	NOUN
4q77fq9958t	5	20	products	product	NOUN
4q77fq9958t	5	21	.	.	PUNCT
4q77fq9958t	6	1	the	the	DET
4q77fq9958t	6	2	synthesis	synthesis	NOUN
4q77fq9958t	6	3	of	of	ADP
4q77fq9958t	6	4	natural	natural	ADJ
4q77fq9958t	6	5	product	product	NOUN
4q77fq9958t	6	6	analogues	analogue	NOUN
4q77fq9958t	6	7	has	have	AUX
4q77fq9958t	6	8	also	also	ADV
4q77fq9958t	6	9	been	be	AUX
4q77fq9958t	6	10	addressed	address	VERB
4q77fq9958t	6	11	in	in	ADP
4q77fq9958t	6	12	the	the	DET
4q77fq9958t	6	13	course	course	NOUN
4q77fq9958t	6	14	of	of	ADP
4q77fq9958t	6	15	this	this	DET
4q77fq9958t	6	16	research	research	NOUN
4q77fq9958t	6	17	.	.	PUNCT
4q77fq9958t	7	1	specifically	specifically	ADV
4q77fq9958t	7	2	,	,	PUNCT
4q77fq9958t	7	3	the	the	DET
4q77fq9958t	7	4	total	total	ADJ
4q77fq9958t	7	5	synthesis	synthesis	NOUN
4q77fq9958t	7	6	of	of	ADP
4q77fq9958t	7	7	a	a	DET
4q77fq9958t	7	8	hybrid	hybrid	ADJ
4q77fq9958t	7	9	analogue	analogue	NOUN
4q77fq9958t	7	10	of	of	ADP
4q77fq9958t	7	11	the	the	DET
4q77fq9958t	7	12	epothilones	epothilone	NOUN
4q77fq9958t	7	13	has	have	AUX
4q77fq9958t	7	14	been	be	AUX
4q77fq9958t	7	15	undertaken	undertake	VERB
4q77fq9958t	7	16	affording	afford	VERB
4q77fq9958t	7	17	two	two	NUM
4q77fq9958t	7	18	analogues	analogue	NOUN
4q77fq9958t	7	19	containing	contain	VERB
4q77fq9958t	7	20	both	both	CCONJ
4q77fq9958t	7	21	a	a	DET
4q77fq9958t	7	22	c14	c14	NOUN
4q77fq9958t	7	23	methyl	methyl	NOUN
4q77fq9958t	7	24	group	group	NOUN
4q77fq9958t	7	25	and	and	CCONJ
4q77fq9958t	7	26	a	a	DET
4q77fq9958t	7	27	c9ìâåâ	c9ìâåâ	PROPN
4q77fq9958t	7	28	-	-	PUNCT
4q77fq9958t	7	29	c10	c10	PROPN
4q77fq9958t	7	30	olefin	olefin	NOUN
4q77fq9958t	7	31	,	,	PUNCT
4q77fq9958t	7	32	both	both	PRON
4q77fq9958t	7	33	designed	design	VERB
4q77fq9958t	7	34	to	to	PART
4q77fq9958t	7	35	impact	impact	VERB
4q77fq9958t	7	36	the	the	DET
4q77fq9958t	7	37	conformation	conformation	NOUN
4q77fq9958t	7	38	of	of	ADP
4q77fq9958t	7	39	the	the	DET
4q77fq9958t	7	40	macrocycle	macrocycle	NOUN
4q77fq9958t	7	41	.	.	PUNCT
4q77fq9958t	8	1	in	in	ADP
4q77fq9958t	8	2	the	the	DET
4q77fq9958t	8	3	course	course	NOUN
4q77fq9958t	8	4	of	of	ADP
4q77fq9958t	8	5	the	the	DET
4q77fq9958t	8	6	synthesis	synthesis	NOUN
4q77fq9958t	8	7	,	,	PUNCT
4q77fq9958t	8	8	a	a	DET
4q77fq9958t	8	9	new	new	ADJ
4q77fq9958t	8	10	methodology	methodology	NOUN
4q77fq9958t	8	11	was	be	AUX
4q77fq9958t	8	12	employed	employ	VERB
4q77fq9958t	8	13	to	to	PART
4q77fq9958t	8	14	install	install	VERB
4q77fq9958t	8	15	the	the	DET
4q77fq9958t	8	16	c14ìâåâ	c14ìâåâ	PROPN
4q77fq9958t	8	17	methyl	methyl	NOUN
4q77fq9958t	8	18	group	group	NOUN
4q77fq9958t	8	19	,	,	PUNCT
4q77fq9958t	8	20	employing	employ	VERB
4q77fq9958t	8	21	the	the	DET
4q77fq9958t	8	22	magnesium	magnesium	NOUN
4q77fq9958t	8	23	-	-	PUNCT
4q77fq9958t	8	24	catalyzed	catalyze	VERB
4q77fq9958t	8	25	anti	anti	ADJ
4q77fq9958t	8	26	-	-	ADJ
4q77fq9958t	8	27	aldol	aldol	ADJ
4q77fq9958t	8	28	chemistry	chemistry	NOUN
4q77fq9958t	8	29	developed	develop	VERB
4q77fq9958t	8	30	by	by	ADP
4q77fq9958t	8	31	evans	evan	NOUN
4q77fq9958t	8	32	.	.	PUNCT
4q77fq9958t	9	1	this	this	DET
4q77fq9958t	9	2	reaction	reaction	NOUN
4q77fq9958t	9	3	provided	provide	VERB
4q77fq9958t	9	4	a	a	DET
4q77fq9958t	9	5	simple	simple	ADJ
4q77fq9958t	9	6	and	and	CCONJ
4q77fq9958t	9	7	highly	highly	ADV
4q77fq9958t	9	8	selective	selective	ADJ
4q77fq9958t	9	9	method	method	NOUN
4q77fq9958t	9	10	to	to	PART
4q77fq9958t	9	11	install	install	VERB
4q77fq9958t	9	12	the	the	DET
4q77fq9958t	9	13	c14	c14	NOUN
4q77fq9958t	9	14	and	and	CCONJ
4q77fq9958t	9	15	c15	c15	NOUN
4q77fq9958t	9	16	stereocenters	stereocenter	NOUN
4q77fq9958t	9	17	in	in	ADP
4q77fq9958t	9	18	a	a	DET
4q77fq9958t	9	19	single	single	ADJ
4q77fq9958t	9	20	and	and	CCONJ
4q77fq9958t	9	21	high	high	ADV
4q77fq9958t	9	22	-	-	PUNCT
4q77fq9958t	9	23	yielding	yield	VERB
4q77fq9958t	9	24	step	step	NOUN
4q77fq9958t	9	25	.	.	PUNCT
4q77fq9958t	10	1	a	a	DET
4q77fq9958t	10	2	final	final	ADJ
4q77fq9958t	10	3	and	and	CCONJ
4q77fq9958t	10	4	novel	novel	ADJ
4q77fq9958t	10	5	project	project	NOUN
4q77fq9958t	10	6	in	in	ADP
4q77fq9958t	10	7	our	our	PRON
4q77fq9958t	10	8	efforts	effort	NOUN
4q77fq9958t	10	9	toward	toward	ADP
4q77fq9958t	10	10	polyketides	polyketide	NOUN
4q77fq9958t	10	11	is	be	AUX
4q77fq9958t	10	12	the	the	DET
4q77fq9958t	10	13	design	design	NOUN
4q77fq9958t	10	14	of	of	ADP
4q77fq9958t	10	15	analogues	analogue	NOUN
4q77fq9958t	10	16	based	base	VERB
4q77fq9958t	10	17	on	on	ADP
4q77fq9958t	10	18	analysis	analysis	NOUN
4q77fq9958t	10	19	of	of	ADP
4q77fq9958t	10	20	solution	solution	NOUN
4q77fq9958t	10	21	conformation	conformation	NOUN
4q77fq9958t	10	22	.	.	PUNCT
4q77fq9958t	11	1	this	this	DET
4q77fq9958t	11	2	research	research	NOUN
4q77fq9958t	11	3	has	have	AUX
4q77fq9958t	11	4	provided	provide	VERB
4q77fq9958t	11	5	an	an	DET
4q77fq9958t	11	6	advanced	advanced	ADJ
4q77fq9958t	11	7	spreadsheet	spreadsheet	NOUN
4q77fq9958t	11	8	-	-	PUNCT
4q77fq9958t	11	9	based	base	VERB
4q77fq9958t	11	10	method	method	NOUN
4q77fq9958t	11	11	to	to	PART
4q77fq9958t	11	12	process	process	VERB
4q77fq9958t	11	13	data	datum	NOUN
4q77fq9958t	11	14	generated	generate	VERB
4q77fq9958t	11	15	by	by	ADP
4q77fq9958t	11	16	a	a	DET
4q77fq9958t	11	17	strategy	strategy	NOUN
4q77fq9958t	11	18	of	of	ADP
4q77fq9958t	11	19	molecular	molecular	ADJ
4q77fq9958t	11	20	modeling	modeling	NOUN
4q77fq9958t	11	21	and	and	CCONJ
4q77fq9958t	11	22	dihedral	dihedral	NOUN
4q77fq9958t	11	23	determination	determination	NOUN
4q77fq9958t	11	24	into	into	ADP
4q77fq9958t	11	25	polar	polar	ADJ
4q77fq9958t	11	26	coordinate	coordinate	NOUN
4q77fq9958t	11	27	maps	map	NOUN
4q77fq9958t	11	28	suitable	suitable	ADJ
4q77fq9958t	11	29	for	for	ADP
4q77fq9958t	11	30	analysis	analysis	NOUN
4q77fq9958t	11	31	of	of	ADP
4q77fq9958t	11	32	large	large	ADJ
4q77fq9958t	11	33	amounts	amount	NOUN
4q77fq9958t	11	34	of	of	ADP
4q77fq9958t	11	35	conformational	conformational	ADJ
4q77fq9958t	11	36	data	datum	NOUN
4q77fq9958t	11	37	.	.	PUNCT
4q77fq9958t	12	1	in	in	ADP
4q77fq9958t	12	2	addition	addition	NOUN
4q77fq9958t	12	3	,	,	PUNCT
4q77fq9958t	12	4	comparisons	comparison	NOUN
4q77fq9958t	12	5	of	of	ADP
4q77fq9958t	12	6	molecular	molecular	ADJ
4q77fq9958t	12	7	modeling	modeling	NOUN
4q77fq9958t	12	8	of	of	ADP
4q77fq9958t	12	9	peloruside	peloruside	PROPN
4q77fq9958t	12	10	a	a	PRON
4q77fq9958t	12	11	has	have	AUX
4q77fq9958t	12	12	been	be	AUX
4q77fq9958t	12	13	accomplished	accomplish	VERB
4q77fq9958t	12	14	by	by	ADP
4q77fq9958t	12	15	an	an	DET
4q77fq9958t	12	16	array	array	NOUN
4q77fq9958t	12	17	of	of	ADP
4q77fq9958t	12	18	diverse	diverse	ADJ
4q77fq9958t	12	19	force	force	NOUN
4q77fq9958t	12	20	fields	field	NOUN
4q77fq9958t	12	21	using	use	VERB
4q77fq9958t	12	22	the	the	DET
4q77fq9958t	12	23	conformational	conformational	ADJ
4q77fq9958t	12	24	search	search	NOUN
4q77fq9958t	12	25	routines	routine	NOUN
4q77fq9958t	12	26	of	of	ADP
4q77fq9958t	12	27	the	the	DET
4q77fq9958t	12	28	macromodel	macromodel	NOUN
4q77fq9958t	12	29	software	software	NOUN
4q77fq9958t	12	30	.	.	PUNCT
4q77fq9958t	13	1	this	this	DET
4q77fq9958t	13	2	analysis	analysis	NOUN
4q77fq9958t	13	3	has	have	AUX
4q77fq9958t	13	4	revealed	reveal	VERB
4q77fq9958t	13	5	interesting	interesting	ADJ
4q77fq9958t	13	6	conformational	conformational	ADJ
4q77fq9958t	13	7	preferences	preference	NOUN
4q77fq9958t	13	8	of	of	ADP
4q77fq9958t	13	9	the	the	DET
4q77fq9958t	13	10	c9	c9	NOUN
4q77fq9958t	13	11	-	-	PUNCT
4q77fq9958t	13	12	c15	c15	NUM
4q77fq9958t	13	13	region	region	NOUN
4q77fq9958t	13	14	of	of	ADP
4q77fq9958t	13	15	peloruside	peloruside	PROPN
4q77fq9958t	13	16	,	,	PUNCT
4q77fq9958t	13	17	which	which	PRON
4q77fq9958t	13	18	may	may	AUX
4q77fq9958t	13	19	be	be	AUX
4q77fq9958t	13	20	exploited	exploit	VERB
4q77fq9958t	13	21	in	in	ADP
4q77fq9958t	13	22	the	the	DET
4q77fq9958t	13	23	design	design	NOUN
4q77fq9958t	13	24	of	of	ADP
4q77fq9958t	13	25	novel	novel	ADJ
4q77fq9958t	13	26	analogues	analogue	NOUN
4q77fq9958t	13	27	based	base	VERB
4q77fq9958t	13	28	on	on	ADP
4q77fq9958t	13	29	molecular	molecular	ADJ
4q77fq9958t	13	30	conformation	conformation	NOUN
4q77fq9958t	13	31	.	.	PUNCT
4q77fq9958t	14	1	supplemental	supplemental	ADJ
4q77fq9958t	14	2	data	datum	NOUN
4q77fq9958t	14	3	not	not	PART
4q77fq9958t	14	4	included	include	VERB
4q77fq9958t	14	5	in	in	ADP
4q77fq9958t	14	6	the	the	DET
4q77fq9958t	14	7	dissertation	dissertation	NOUN
4q77fq9958t	14	8	:	:	PUNCT
4q77fq9958t	14	9	nicholsonc_data_mm2.zip	nicholsonc_data_mm2.zip	PROPN
4q77fq9958t	14	10	(	(	PUNCT
4q77fq9958t	14	11	151	151	NUM
4q77fq9958t	14	12	mb	mb	NOUN
4q77fq9958t	14	13	)	)	PUNCT
4q77fq9958t	14	14	nicholsonc_data_mm3.zip	nicholsonc_data_mm3.zip	PROPN
4q77fq9958t	14	15	(	(	PUNCT
4q77fq9958t	14	16	154	154	NUM
4q77fq9958t	14	17	mb	mb	NOUN
4q77fq9958t	14	18	)	)	PUNCT
4q77fq9958t	14	19	nicholsonc_data_opls.zip	nicholsonc_data_opls.zip	X
4q77fq9958t	14	20	(	(	PUNCT
4q77fq9958t	14	21	19.1	19.1	NUM
4q77fq9958t	14	22	mb	mb	NOUN
4q77fq9958t	14	23	)	)	PUNCT