id sid tid token lemma pos 4m90dv1624f 1 1 the the DET 4m90dv1624f 1 2 tumor tumor NOUN 4m90dv1624f 1 3 microenvironment microenvironment NOUN 4m90dv1624f 1 4 ( ( PUNCT 4m90dv1624f 1 5 tme tme PROPN 4m90dv1624f 1 6 ) ) PUNCT 4m90dv1624f 1 7 – – PUNCT 4m90dv1624f 1 8 the the DET 4m90dv1624f 1 9 dynamic dynamic ADJ 4m90dv1624f 1 10 tissue tissue NOUN 4m90dv1624f 1 11 space space NOUN 4m90dv1624f 1 12 in in ADP 4m90dv1624f 1 13 which which PRON 4m90dv1624f 1 14 the the DET 4m90dv1624f 1 15 tumor tumor NOUN 4m90dv1624f 1 16 exists exist VERB 4m90dv1624f 1 17 – – PUNCT 4m90dv1624f 1 18 plays play VERB 4m90dv1624f 1 19 a a DET 4m90dv1624f 1 20 significant significant ADJ 4m90dv1624f 1 21 role role NOUN 4m90dv1624f 1 22 in in ADP 4m90dv1624f 1 23 tumor tumor NOUN 4m90dv1624f 1 24 initiation initiation NOUN 4m90dv1624f 1 25 and and CCONJ 4m90dv1624f 1 26 is be AUX 4m90dv1624f 1 27 a a DET 4m90dv1624f 1 28 key key ADJ 4m90dv1624f 1 29 contributor contributor NOUN 4m90dv1624f 1 30 in in ADP 4m90dv1624f 1 31 cancer cancer NOUN 4m90dv1624f 1 32 progression progression NOUN 4m90dv1624f 1 33 ; ; PUNCT 4m90dv1624f 1 34 however however ADV 4m90dv1624f 1 35 , , PUNCT 4m90dv1624f 1 36 little little ADJ 4m90dv1624f 1 37 is be AUX 4m90dv1624f 1 38 known know VERB 4m90dv1624f 1 39 about about ADP 4m90dv1624f 1 40 tumor tumor NOUN 4m90dv1624f 1 41 - - PUNCT 4m90dv1624f 1 42 induced induce VERB 4m90dv1624f 1 43 changes change NOUN 4m90dv1624f 1 44 in in ADP 4m90dv1624f 1 45 the the DET 4m90dv1624f 1 46 adjacent adjacent ADJ 4m90dv1624f 1 47 tissue tissue NOUN 4m90dv1624f 1 48 stroma stroma NOUN 4m90dv1624f 1 49 . . PUNCT 4m90dv1624f 2 1 herein herein ADV 4m90dv1624f 2 2 , , PUNCT 4m90dv1624f 2 3 we we PRON 4m90dv1624f 2 4 sought seek VERB 4m90dv1624f 2 5 to to PART 4m90dv1624f 2 6 explore explore VERB 4m90dv1624f 2 7 tumor tumor NOUN 4m90dv1624f 2 8 - - PUNCT 4m90dv1624f 2 9 induced induce VERB 4m90dv1624f 2 10 changes change NOUN 4m90dv1624f 2 11 in in ADP 4m90dv1624f 2 12 the the DET 4m90dv1624f 2 13 tme tme NOUN 4m90dv1624f 2 14 at at ADP 4m90dv1624f 2 15 the the DET 4m90dv1624f 2 16 morphological morphological ADJ 4m90dv1624f 2 17 and and CCONJ 4m90dv1624f 2 18 molecular molecular ADJ 4m90dv1624f 2 19 level level NOUN 4m90dv1624f 2 20 to to PART 4m90dv1624f 2 21 further far ADV 4m90dv1624f 2 22 characterize characterize VERB 4m90dv1624f 2 23 cancer cancer NOUN 4m90dv1624f 2 24 progression progression NOUN 4m90dv1624f 2 25 . . PUNCT 4m90dv1624f 3 1 we we PRON 4m90dv1624f 3 2 show show VERB 4m90dv1624f 3 3 that that SCONJ 4m90dv1624f 3 4 tumor tumor NOUN 4m90dv1624f 3 5 - - PUNCT 4m90dv1624f 3 6 adjacent adjacent ADJ 4m90dv1624f 3 7 mammary mammary ADJ 4m90dv1624f 3 8 glands gland NOUN 4m90dv1624f 3 9 ( ( PUNCT 4m90dv1624f 3 10 tags tag NOUN 4m90dv1624f 3 11 ) ) PUNCT 4m90dv1624f 3 12 display display NOUN 4m90dv1624f 3 13 altered alter VERB 4m90dv1624f 3 14 branching branching NOUN 4m90dv1624f 3 15 morphology morphology NOUN 4m90dv1624f 3 16 , , PUNCT 4m90dv1624f 3 17 expansion expansion NOUN 4m90dv1624f 3 18 of of ADP 4m90dv1624f 3 19 myofibroblasts myofibroblast NOUN 4m90dv1624f 3 20 , , PUNCT 4m90dv1624f 3 21 and and CCONJ 4m90dv1624f 3 22 increased increase VERB 4m90dv1624f 3 23 mammosphere mammosphere ADJ 4m90dv1624f 3 24 formation formation NOUN 4m90dv1624f 3 25 , , PUNCT 4m90dv1624f 3 26 broadly broadly ADV 4m90dv1624f 3 27 suggesting suggest VERB 4m90dv1624f 3 28 a a DET 4m90dv1624f 3 29 tumor tumor NOUN 4m90dv1624f 3 30 - - PUNCT 4m90dv1624f 3 31 induced induce VERB 4m90dv1624f 3 32 field field NOUN 4m90dv1624f 3 33 effect effect NOUN 4m90dv1624f 3 34 . . PUNCT 4m90dv1624f 4 1 facs fac NOUN 4m90dv1624f 4 2 analysis analysis NOUN 4m90dv1624f 4 3 showed show VERB 4m90dv1624f 4 4 that that SCONJ 4m90dv1624f 4 5 tags tag NOUN 4m90dv1624f 4 6 contain contain VERB 4m90dv1624f 4 7 an an DET 4m90dv1624f 4 8 increased increase VERB 4m90dv1624f 4 9 number number NOUN 4m90dv1624f 4 10 of of ADP 4m90dv1624f 4 11 lin lin PROPN 4m90dv1624f 4 12 - - PUNCT 4m90dv1624f 4 13 cd24+/cd49 cd24+/cd49 SPACE 4m90dv1624f 4 14 + + CCONJ 4m90dv1624f 4 15 enriched enrich VERB 4m90dv1624f 4 16 mammary mammary ADJ 4m90dv1624f 4 17 gland gland NOUN 4m90dv1624f 4 18 stem stem NOUN 4m90dv1624f 4 19 cells cell NOUN 4m90dv1624f 4 20 ( ( PUNCT 4m90dv1624f 4 21 mascs masc NOUN 4m90dv1624f 4 22 ) ) PUNCT 4m90dv1624f 4 23 , , PUNCT 4m90dv1624f 4 24 suggesting suggest VERB 4m90dv1624f 4 25 deregulated deregulated ADJ 4m90dv1624f 4 26 tissue tissue NOUN 4m90dv1624f 4 27 homeostasis homeostasis NOUN 4m90dv1624f 4 28 in in ADP 4m90dv1624f 4 29 tags tag NOUN 4m90dv1624f 4 30 . . PUNCT 4m90dv1624f 5 1 comparative comparative ADJ 4m90dv1624f 5 2 transcriptome transcriptome ADJ 4m90dv1624f 5 3 analysis analysis NOUN 4m90dv1624f 5 4 of of ADP 4m90dv1624f 5 5 tags tag NOUN 4m90dv1624f 5 6 and and CCONJ 4m90dv1624f 5 7 contralateral contralateral ADJ 4m90dv1624f 5 8 control control NOUN 4m90dv1624f 5 9 glands gland NOUN 4m90dv1624f 5 10 coupled couple VERB 4m90dv1624f 5 11 with with ADP 4m90dv1624f 5 12 meta meta NOUN 4m90dv1624f 5 13 - - NOUN 4m90dv1624f 5 14 analysis analysis NOUN 4m90dv1624f 5 15 on on ADP 4m90dv1624f 5 16 differentially differentially ADV 4m90dv1624f 5 17 expressed express VERB 4m90dv1624f 5 18 genes gene NOUN 4m90dv1624f 5 19 with with ADP 4m90dv1624f 5 20 two two NUM 4m90dv1624f 5 21 breast breast NOUN 4m90dv1624f 5 22 cancer cancer NOUN 4m90dv1624f 5 23 stromal stromal PROPN 4m90dv1624f 5 24 patient patient PROPN 4m90dv1624f 5 25 microarray microarray PROPN 4m90dv1624f 5 26 datasets dataset NOUN 4m90dv1624f 5 27 identified identify VERB 4m90dv1624f 5 28 shared share VERB 4m90dv1624f 5 29 upregulation upregulation NOUN 4m90dv1624f 5 30 of of ADP 4m90dv1624f 5 31 stat1 stat1 PROPN 4m90dv1624f 5 32 . . PUNCT 4m90dv1624f 6 1 knockdown knockdown NOUN 4m90dv1624f 6 2 of of ADP 4m90dv1624f 6 3 stat1 stat1 PROPN 4m90dv1624f 6 4 in in ADP 4m90dv1624f 6 5 cancer cancer NOUN 4m90dv1624f 6 6 associated associate VERB 4m90dv1624f 6 7 fibroblast fibroblast NOUN 4m90dv1624f 6 8 ( ( PUNCT 4m90dv1624f 6 9 cafs cafs PROPN 4m90dv1624f 6 10 ) ) PUNCT 4m90dv1624f 6 11 cocultured coculture VERB 4m90dv1624f 6 12 with with ADP 4m90dv1624f 6 13 human human ADJ 4m90dv1624f 6 14 breast breast NOUN 4m90dv1624f 6 15 cancer cancer NOUN 4m90dv1624f 6 16 cells cell NOUN 4m90dv1624f 6 17 altered alter VERB 4m90dv1624f 6 18 cancer cancer NOUN 4m90dv1624f 6 19 cell cell NOUN 4m90dv1624f 6 20 proliferation proliferation NOUN 4m90dv1624f 6 21 , , PUNCT 4m90dv1624f 6 22 further far ADV 4m90dv1624f 6 23 suggesting suggest VERB 4m90dv1624f 6 24 the the DET 4m90dv1624f 6 25 role role NOUN 4m90dv1624f 6 26 of of ADP 4m90dv1624f 6 27 stat1 stat1 NOUN 4m90dv1624f 6 28 as as ADP 4m90dv1624f 6 29 a a DET 4m90dv1624f 6 30 stromal stromal ADJ 4m90dv1624f 6 31 contributor contributor NOUN 4m90dv1624f 6 32 of of ADP 4m90dv1624f 6 33 tumorigenesis tumorigenesis NOUN 4m90dv1624f 6 34 . . PUNCT 4m90dv1624f 7 1 furthermore furthermore ADV 4m90dv1624f 7 2 , , PUNCT 4m90dv1624f 7 3 depletion depletion NOUN 4m90dv1624f 7 4 of of ADP 4m90dv1624f 7 5 stat1 stat1 PROPN 4m90dv1624f 7 6 in in ADP 4m90dv1624f 7 7 cafs cafs NOUN 4m90dv1624f 7 8 significantly significantly ADV 4m90dv1624f 7 9 reduced reduce VERB 4m90dv1624f 7 10 periductal periductal ADJ 4m90dv1624f 7 11 reactive reactive ADJ 4m90dv1624f 7 12 fibrosis fibrosis NOUN 4m90dv1624f 7 13 and and CCONJ 4m90dv1624f 7 14 delayed delay VERB 4m90dv1624f 7 15 early early ADJ 4m90dv1624f 7 16 breast breast NOUN 4m90dv1624f 7 17 cancer cancer NOUN 4m90dv1624f 7 18 progression progression NOUN 4m90dv1624f 7 19 in in ADP 4m90dv1624f 7 20 vivo vivo PROPN 4m90dv1624f 7 21 . . PUNCT 4m90dv1624f 8 1 lastly lastly ADV 4m90dv1624f 8 2 , , PUNCT 4m90dv1624f 8 3 co co NOUN 4m90dv1624f 8 4 - - NOUN 4m90dv1624f 8 5 treatment treatment NOUN 4m90dv1624f 8 6 with with ADP 4m90dv1624f 8 7 fludarabine fludarabine NOUN 4m90dv1624f 8 8 , , PUNCT 4m90dv1624f 8 9 a a DET 4m90dv1624f 8 10 fda fda PROPN 4m90dv1624f 8 11 - - PUNCT 4m90dv1624f 8 12 approved approve VERB 4m90dv1624f 8 13 stat1 stat1 NOUN 4m90dv1624f 8 14 activation activation NOUN 4m90dv1624f 8 15 inhibitor inhibitor NOUN 4m90dv1624f 8 16 and and CCONJ 4m90dv1624f 8 17 dna dna NOUN 4m90dv1624f 8 18 synthesis synthesis NOUN 4m90dv1624f 8 19 inhibitor inhibitor NOUN 4m90dv1624f 8 20 , , PUNCT 4m90dv1624f 8 21 in in ADP 4m90dv1624f 8 22 combination combination NOUN 4m90dv1624f 8 23 with with ADP 4m90dv1624f 8 24 doxorubicin doxorubicin NOUN 4m90dv1624f 8 25 , , PUNCT 4m90dv1624f 8 26 showed show VERB 4m90dv1624f 8 27 enhanced enhanced ADJ 4m90dv1624f 8 28 therapeutic therapeutic ADJ 4m90dv1624f 8 29 efficacy efficacy NOUN 4m90dv1624f 8 30 in in ADP 4m90dv1624f 8 31 treating treat VERB 4m90dv1624f 8 32 mouse mouse NOUN 4m90dv1624f 8 33 mammary mammary ADJ 4m90dv1624f 8 34 gland gland NOUN 4m90dv1624f 8 35 tumors tumor NOUN 4m90dv1624f 8 36 . . PUNCT 4m90dv1624f 9 1 taken take VERB 4m90dv1624f 9 2 together together ADV 4m90dv1624f 9 3 , , PUNCT 4m90dv1624f 9 4 our our PRON 4m90dv1624f 9 5 results result NOUN 4m90dv1624f 9 6 demonstrate demonstrate VERB 4m90dv1624f 9 7 that that SCONJ 4m90dv1624f 9 8 stromal stromal PROPN 4m90dv1624f 9 9 stat1 stat1 NOUN 4m90dv1624f 9 10 expression expression NOUN 4m90dv1624f 9 11 promotes promote VERB 4m90dv1624f 9 12 tumor tumor NOUN 4m90dv1624f 9 13 progression progression NOUN 4m90dv1624f 9 14 and and CCONJ 4m90dv1624f 9 15 is be AUX 4m90dv1624f 9 16 a a DET 4m90dv1624f 9 17 potential potential ADJ 4m90dv1624f 9 18 therapeutic therapeutic ADJ 4m90dv1624f 9 19 target target NOUN 4m90dv1624f 9 20 for for ADP 4m90dv1624f 9 21 breast breast NOUN 4m90dv1624f 9 22 cancer cancer NOUN 4m90dv1624f 9 23 . . PUNCT