id	sid	tid	token	lemma	pos
4j03cz33p96	1	1	polyketide	polyketide	PROPN
4j03cz33p96	1	2	natural	natural	ADJ
4j03cz33p96	1	3	products	product	NOUN
4j03cz33p96	1	4	have	have	AUX
4j03cz33p96	1	5	drawn	draw	VERB
4j03cz33p96	1	6	attention	attention	NOUN
4j03cz33p96	1	7	from	from	ADP
4j03cz33p96	1	8	the	the	DET
4j03cz33p96	1	9	synthetic	synthetic	ADJ
4j03cz33p96	1	10	community	community	NOUN
4j03cz33p96	1	11	due	due	ADP
4j03cz33p96	1	12	to	to	ADP
4j03cz33p96	1	13	complex	complex	ADJ
4j03cz33p96	1	14	molecular	molecular	ADJ
4j03cz33p96	1	15	structures	structure	NOUN
4j03cz33p96	1	16	and	and	CCONJ
4j03cz33p96	1	17	unique	unique	ADJ
4j03cz33p96	1	18	biological	biological	ADJ
4j03cz33p96	1	19	activities	activity	NOUN
4j03cz33p96	1	20	.	.	PUNCT
4j03cz33p96	2	1	polyketides	polyketide	NOUN
4j03cz33p96	2	2	are	be	AUX
4j03cz33p96	2	3	biosynthesized	biosynthesize	VERB
4j03cz33p96	2	4	by	by	ADP
4j03cz33p96	2	5	numerous	numerous	ADJ
4j03cz33p96	2	6	species	specie	NOUN
4j03cz33p96	2	7	via	via	ADP
4j03cz33p96	2	8	large	large	ADJ
4j03cz33p96	2	9	polyketide	polyketide	NOUN
4j03cz33p96	2	10	synthases	synthase	NOUN
4j03cz33p96	2	11	which	which	PRON
4j03cz33p96	2	12	act	act	VERB
4j03cz33p96	2	13	as	as	ADP
4j03cz33p96	2	14	assembly	assembly	NOUN
4j03cz33p96	2	15	lines	line	NOUN
4j03cz33p96	2	16	to	to	PART
4j03cz33p96	2	17	produce	produce	VERB
4j03cz33p96	2	18	large	large	ADJ
4j03cz33p96	2	19	natural	natural	ADJ
4j03cz33p96	2	20	products	product	NOUN
4j03cz33p96	2	21	from	from	ADP
4j03cz33p96	2	22	malonyland	malonyland	PROPN
4j03cz33p96	2	23	methylmalonyl	methylmalonyl	NOUN
4j03cz33p96	2	24	-	-	PUNCT
4j03cz33p96	2	25	coa	coa	NOUN
4j03cz33p96	2	26	subunits	subunit	NOUN
4j03cz33p96	2	27	.	.	PUNCT
4j03cz33p96	3	1	accessory	accessory	NOUN
4j03cz33p96	3	2	domains	domain	NOUN
4j03cz33p96	3	3	and	and	CCONJ
4j03cz33p96	3	4	post	post	NOUN
4j03cz33p96	3	5	polyketide	polyketide	NOUN
4j03cz33p96	3	6	synthesis	synthesis	NOUN
4j03cz33p96	3	7	tailoring	tailor	VERB
4j03cz33p96	3	8	install	install	VERB
4j03cz33p96	3	9	many	many	ADJ
4j03cz33p96	3	10	oxidative	oxidative	ADJ
4j03cz33p96	3	11	and	and	CCONJ
4j03cz33p96	3	12	stereochemically	stereochemically	ADV
4j03cz33p96	3	13	relevant	relevant	ADJ
4j03cz33p96	3	14	elements	element	NOUN
4j03cz33p96	3	15	necessary	necessary	ADJ
4j03cz33p96	3	16	for	for	ADP
4j03cz33p96	3	17	biological	biological	ADJ
4j03cz33p96	3	18	activity	activity	NOUN
4j03cz33p96	3	19	.	.	PUNCT
4j03cz33p96	4	1	the	the	DET
4j03cz33p96	4	2	intrinsic	intrinsic	ADJ
4j03cz33p96	4	3	stereochemistry	stereochemistry	NOUN
4j03cz33p96	4	4	about	about	ADP
4j03cz33p96	4	5	the	the	DET
4j03cz33p96	4	6	molecular	molecular	ADJ
4j03cz33p96	4	7	backbone	backbone	NOUN
4j03cz33p96	4	8	of	of	ADP
4j03cz33p96	4	9	the	the	DET
4j03cz33p96	4	10	molecules	molecule	NOUN
4j03cz33p96	4	11	afford	afford	VERB
4j03cz33p96	4	12	distinct	distinct	ADJ
4j03cz33p96	4	13	conformational	conformational	ADJ
4j03cz33p96	4	14	preferences	preference	NOUN
4j03cz33p96	4	15	which	which	PRON
4j03cz33p96	4	16	give	give	VERB
4j03cz33p96	4	17	these	these	DET
4j03cz33p96	4	18	large	large	ADJ
4j03cz33p96	4	19	and	and	CCONJ
4j03cz33p96	4	20	complex	complex	ADJ
4j03cz33p96	4	21	molecules	molecule	NOUN
4j03cz33p96	4	22	a	a	DET
4j03cz33p96	4	23	defined	define	VERB
4j03cz33p96	4	24	shape.herein	shape.herein	NOUN
4j03cz33p96	4	25	is	be	AUX
4j03cz33p96	4	26	described	describe	VERB
4j03cz33p96	4	27	the	the	DET
4j03cz33p96	4	28	relationship	relationship	NOUN
4j03cz33p96	4	29	between	between	ADP
4j03cz33p96	4	30	conformational	conformational	ADJ
4j03cz33p96	4	31	preference	preference	NOUN
4j03cz33p96	4	32	and	and	CCONJ
4j03cz33p96	4	33	biological	biological	ADJ
4j03cz33p96	4	34	properties	property	NOUN
4j03cz33p96	4	35	of	of	ADP
4j03cz33p96	4	36	the	the	DET
4j03cz33p96	4	37	type	type	NOUN
4j03cz33p96	4	38	-	-	PUNCT
4j03cz33p96	4	39	i	i	PROPN
4j03cz33p96	4	40	polyketide	polyketide	NOUN
4j03cz33p96	4	41	natural	natural	ADJ
4j03cz33p96	4	42	product	product	NOUN
4j03cz33p96	4	43	gex1a	gex1a	PROPN
4j03cz33p96	4	44	(	(	PUNCT
4j03cz33p96	4	45	herboxidiene	herboxidiene	PROPN
4j03cz33p96	4	46	)	)	PUNCT
4j03cz33p96	4	47	.	.	PUNCT
4j03cz33p96	5	1	our	our	PRON
4j03cz33p96	5	2	laboratory	laboratory	NOUN
4j03cz33p96	5	3	has	have	AUX
4j03cz33p96	5	4	utilized	utilize	VERB
4j03cz33p96	5	5	total	total	ADJ
4j03cz33p96	5	6	synthesis	synthesis	NOUN
4j03cz33p96	5	7	,	,	PUNCT
4j03cz33p96	5	8	semi	semi	ADJ
4j03cz33p96	5	9	-	-	NOUN
4j03cz33p96	5	10	synthesis	synthesis	NOUN
4j03cz33p96	5	11	,	,	PUNCT
4j03cz33p96	5	12	and	and	CCONJ
4j03cz33p96	5	13	fermentation	fermentation	NOUN
4j03cz33p96	5	14	of	of	ADP
4j03cz33p96	5	15	bacterial	bacterial	ADJ
4j03cz33p96	5	16	species	specie	NOUN
4j03cz33p96	5	17	to	to	PART
4j03cz33p96	5	18	produce	produce	VERB
4j03cz33p96	5	19	the	the	DET
4j03cz33p96	5	20	natural	natural	ADJ
4j03cz33p96	5	21	products	product	NOUN
4j03cz33p96	5	22	and	and	CCONJ
4j03cz33p96	5	23	analogs	analog	NOUN
4j03cz33p96	5	24	of	of	ADP
4j03cz33p96	5	25	the	the	DET
4j03cz33p96	5	26	natural	natural	ADJ
4j03cz33p96	5	27	product	product	NOUN
4j03cz33p96	5	28	to	to	PART
4j03cz33p96	5	29	study	study	VERB
4j03cz33p96	5	30	the	the	DET
4j03cz33p96	5	31	structures	structure	NOUN
4j03cz33p96	5	32	and	and	CCONJ
4j03cz33p96	5	33	conformational	conformational	ADJ
4j03cz33p96	5	34	preferences	preference	NOUN
4j03cz33p96	5	35	and	and	CCONJ
4j03cz33p96	5	36	the	the	DET
4j03cz33p96	5	37	respective	respective	ADJ
4j03cz33p96	5	38	relationships	relationship	NOUN
4j03cz33p96	5	39	to	to	ADP
4j03cz33p96	5	40	biological	biological	ADJ
4j03cz33p96	5	41	activity	activity	NOUN
4j03cz33p96	5	42	.	.	PUNCT
4j03cz33p96	6	1	we	we	PRON
4j03cz33p96	6	2	utilize	utilize	VERB
4j03cz33p96	6	3	these	these	DET
4j03cz33p96	6	4	studies	study	NOUN
4j03cz33p96	6	5	to	to	PART
4j03cz33p96	6	6	determine	determine	VERB
4j03cz33p96	6	7	new	new	ADJ
4j03cz33p96	6	8	analogs	analog	NOUN
4j03cz33p96	6	9	to	to	PART
4j03cz33p96	6	10	increase	increase	VERB
4j03cz33p96	6	11	therapeutic	therapeutic	ADJ
4j03cz33p96	6	12	potential	potential	NOUN
4j03cz33p96	6	13	in	in	ADP
4j03cz33p96	6	14	future	future	ADJ
4j03cz33p96	6	15	analogs	analog	NOUN
4j03cz33p96	6	16	.	.	PUNCT
4j03cz33p96	7	1	the	the	DET
4j03cz33p96	7	2	first	first	ADJ
4j03cz33p96	7	3	three	three	NUM
4j03cz33p96	7	4	chapters	chapter	NOUN
4j03cz33p96	7	5	of	of	ADP
4j03cz33p96	7	6	this	this	DET
4j03cz33p96	7	7	thesis	thesis	NOUN
4j03cz33p96	7	8	provide	provide	VERB
4j03cz33p96	7	9	background	background	NOUN
4j03cz33p96	7	10	for	for	ADP
4j03cz33p96	7	11	niemann	niemann	PROPN
4j03cz33p96	7	12	-	-	PUNCT
4j03cz33p96	7	13	pick	pick	NOUN
4j03cz33p96	7	14	type	type	NOUN
4j03cz33p96	7	15	c	c	NOUN
4j03cz33p96	7	16	disease	disease	NOUN
4j03cz33p96	7	17	,	,	PUNCT
4j03cz33p96	7	18	rna	rna	NOUN
4j03cz33p96	7	19	binding	bind	VERB
4j03cz33p96	7	20	molecules	molecule	NOUN
4j03cz33p96	7	21	and	and	CCONJ
4j03cz33p96	7	22	their	their	PRON
4j03cz33p96	7	23	therapeutic	therapeutic	ADJ
4j03cz33p96	7	24	relevance	relevance	NOUN
4j03cz33p96	7	25	,	,	PUNCT
4j03cz33p96	7	26	and	and	CCONJ
4j03cz33p96	7	27	analogs	analog	NOUN
4j03cz33p96	7	28	of	of	ADP
4j03cz33p96	7	29	gex1a	gex1a	PROPN
4j03cz33p96	7	30	and	and	CCONJ
4j03cz33p96	7	31	their	their	PRON
4j03cz33p96	7	32	relationship	relationship	NOUN
4j03cz33p96	7	33	with	with	ADP
4j03cz33p96	7	34	biological	biological	ADJ
4j03cz33p96	7	35	activity	activity	NOUN
4j03cz33p96	7	36	.	.	PUNCT
4j03cz33p96	8	1	the	the	DET
4j03cz33p96	8	2	compounds	compound	NOUN
4j03cz33p96	8	3	present	present	ADJ
4j03cz33p96	8	4	as	as	ADP
4j03cz33p96	8	5	viable	viable	ADJ
4j03cz33p96	8	6	therapeutic	therapeutic	ADJ
4j03cz33p96	8	7	agents	agent	NOUN
4j03cz33p96	8	8	in	in	ADP
4j03cz33p96	8	9	several	several	ADJ
4j03cz33p96	8	10	cancers	cancer	NOUN
4j03cz33p96	8	11	and	and	CCONJ
4j03cz33p96	8	12	disease	disease	NOUN
4j03cz33p96	8	13	states	state	NOUN
4j03cz33p96	8	14	.	.	PUNCT
4j03cz33p96	9	1	this	this	DET
4j03cz33p96	9	2	thesis	thesis	NOUN
4j03cz33p96	9	3	will	will	AUX
4j03cz33p96	9	4	focus	focus	VERB
4j03cz33p96	9	5	on	on	ADP
4j03cz33p96	9	6	the	the	DET
4j03cz33p96	9	7	biological	biological	ADJ
4j03cz33p96	9	8	activity	activity	NOUN
4j03cz33p96	9	9	relevant	relevant	ADJ
4j03cz33p96	9	10	to	to	ADP
4j03cz33p96	9	11	acute	acute	VERB
4j03cz33p96	9	12	myeloid	myeloid	PROPN
4j03cz33p96	9	13	leukemia	leukemia	NOUN
4j03cz33p96	9	14	and	and	CCONJ
4j03cz33p96	9	15	niemann	niemann	PROPN
4j03cz33p96	9	16	-	-	PUNCT
4j03cz33p96	9	17	pick	pick	NOUN
4j03cz33p96	9	18	type	type	NOUN
4j03cz33p96	9	19	c.	c.	PROPN
4j03cz33p96	9	20	chapter	chapter	NOUN
4j03cz33p96	9	21	four	four	NUM
4j03cz33p96	9	22	focuses	focus	VERB
4j03cz33p96	9	23	on	on	ADP
4j03cz33p96	9	24	the	the	DET
4j03cz33p96	9	25	development	development	NOUN
4j03cz33p96	9	26	of	of	ADP
4j03cz33p96	9	27	structural	structural	ADJ
4j03cz33p96	9	28	analogs	analog	NOUN
4j03cz33p96	9	29	of	of	ADP
4j03cz33p96	9	30	gex1a	gex1a	PROPN
4j03cz33p96	9	31	to	to	PART
4j03cz33p96	9	32	study	study	VERB
4j03cz33p96	9	33	the	the	DET
4j03cz33p96	9	34	effects	effect	NOUN
4j03cz33p96	9	35	of	of	ADP
4j03cz33p96	9	36	the	the	DET
4j03cz33p96	9	37	'	'	PUNCT
4j03cz33p96	9	38	turn	turn	NOUN
4j03cz33p96	9	39	'	'	PUNCT
4j03cz33p96	9	40	conformation	conformation	NOUN
4j03cz33p96	9	41	observed	observe	VERB
4j03cz33p96	9	42	in	in	ADP
4j03cz33p96	9	43	gex1a	gex1a	PROPN
4j03cz33p96	9	44	and	and	CCONJ
4j03cz33p96	9	45	its	its	PRON
4j03cz33p96	9	46	relation	relation	NOUN
4j03cz33p96	9	47	to	to	PART
4j03cz33p96	9	48	observed	observe	VERB
4j03cz33p96	9	49	biological	biological	ADJ
4j03cz33p96	9	50	activity	activity	NOUN
4j03cz33p96	9	51	.	.	PUNCT
4j03cz33p96	10	1	the	the	DET
4j03cz33p96	10	2	studies	study	NOUN
4j03cz33p96	10	3	herein	herein	ADV
4j03cz33p96	10	4	explore	explore	VERB
4j03cz33p96	10	5	the	the	DET
4j03cz33p96	10	6	structure	structure	NOUN
4j03cz33p96	10	7	of	of	ADP
4j03cz33p96	10	8	gex1a	gex1a	PROPN
4j03cz33p96	10	9	computationally	computationally	ADV
4j03cz33p96	10	10	and	and	CCONJ
4j03cz33p96	10	11	experimentally	experimentally	ADV
4j03cz33p96	10	12	.	.	PUNCT
4j03cz33p96	11	1	total	total	ADJ
4j03cz33p96	11	2	synthesis	synthesis	NOUN
4j03cz33p96	11	3	of	of	ADP
4j03cz33p96	11	4	two	two	NUM
4j03cz33p96	11	5	gex1a	gex1a	PROPN
4j03cz33p96	11	6	conformational	conformational	ADJ
4j03cz33p96	11	7	analogs	analog	NOUN
4j03cz33p96	11	8	has	have	AUX
4j03cz33p96	11	9	been	be	AUX
4j03cz33p96	11	10	completed	complete	VERB
4j03cz33p96	11	11	which	which	PRON
4j03cz33p96	11	12	explore	explore	VERB
4j03cz33p96	11	13	gex1a	gex1a	SPACE
4j03cz33p96	11	14	's	's	PART
4j03cz33p96	11	15	conformational	conformational	ADJ
4j03cz33p96	11	16	families	family	NOUN
4j03cz33p96	11	17	and	and	CCONJ
4j03cz33p96	11	18	the	the	DET
4j03cz33p96	11	19	rigidification	rigidification	NOUN
4j03cz33p96	11	20	of	of	ADP
4j03cz33p96	11	21	the	the	DET
4j03cz33p96	11	22	side	side	NOUN
4j03cz33p96	11	23	chain	chain	NOUN
4j03cz33p96	11	24	to	to	PART
4j03cz33p96	11	25	explore	explore	VERB
4j03cz33p96	11	26	the	the	DET
4j03cz33p96	11	27	impact	impact	NOUN
4j03cz33p96	11	28	on	on	ADP
4j03cz33p96	11	29	the	the	DET
4j03cz33p96	11	30	'	'	PUNCT
4j03cz33p96	11	31	turn	turn	NOUN
4j03cz33p96	11	32	'	'	PUNCT
4j03cz33p96	11	33	conformation	conformation	NOUN
4j03cz33p96	11	34	.	.	PUNCT