id sid tid token lemma pos 4f16c250f9m 1 1 sensitivity sensitivity NOUN 4f16c250f9m 1 2 to to ADP 4f16c250f9m 1 3 immune immune ADJ 4f16c250f9m 1 4 checkpoint checkpoint NOUN 4f16c250f9m 1 5 blockades blockade NOUN 4f16c250f9m 1 6 ( ( PUNCT 4f16c250f9m 1 7 icb icb CCONJ 4f16c250f9m 1 8 ) ) PUNCT 4f16c250f9m 1 9 depends depend VERB 4f16c250f9m 1 10 on on ADP 4f16c250f9m 1 11 the the DET 4f16c250f9m 1 12 overall overall ADJ 4f16c250f9m 1 13 balance balance NOUN 4f16c250f9m 1 14 of of ADP 4f16c250f9m 1 15 immunogenic immunogenic ADJ 4f16c250f9m 1 16 and and CCONJ 4f16c250f9m 1 17 immunosuppressive immunosuppressive ADJ 4f16c250f9m 1 18 signals signal NOUN 4f16c250f9m 1 19 in in ADP 4f16c250f9m 1 20 the the DET 4f16c250f9m 1 21 tumor tumor NOUN 4f16c250f9m 1 22 immune immune ADJ 4f16c250f9m 1 23 microenvironment microenvironment NOUN 4f16c250f9m 1 24 ( ( PUNCT 4f16c250f9m 1 25 time time NOUN 4f16c250f9m 1 26 ) ) PUNCT 4f16c250f9m 1 27 . . PUNCT 4f16c250f9m 2 1 chemotherapy chemotherapy NOUN 4f16c250f9m 2 2 as as ADP 4f16c250f9m 2 3 an an DET 4f16c250f9m 2 4 immunostimulatory immunostimulatory ADJ 4f16c250f9m 2 5 strategy strategy NOUN 4f16c250f9m 2 6 showed show VERB 4f16c250f9m 2 7 potential potential NOUN 4f16c250f9m 2 8 in in ADP 4f16c250f9m 2 9 improving improve VERB 4f16c250f9m 2 10 icb icb PROPN 4f16c250f9m 2 11 's 's PART 4f16c250f9m 2 12 clinical clinical ADJ 4f16c250f9m 2 13 efficacy efficacy NOUN 4f16c250f9m 2 14 . . PUNCT 4f16c250f9m 3 1 yet yet ADV 4f16c250f9m 3 2 , , PUNCT 4f16c250f9m 3 3 evolution evolution NOUN 4f16c250f9m 3 4 of of ADP 4f16c250f9m 3 5 highly highly ADV 4f16c250f9m 3 6 plastic plastic ADJ 4f16c250f9m 3 7 tumor tumor NOUN 4f16c250f9m 3 8 - - PUNCT 4f16c250f9m 3 9 associated associate VERB 4f16c250f9m 3 10 myeloid myeloid PROPN 4f16c250f9m 3 11 cells cell NOUN 4f16c250f9m 3 12 hinders hinder VERB 4f16c250f9m 3 13 icb icb PROPN 4f16c250f9m 3 14 's 's PART 4f16c250f9m 3 15 potential potential NOUN 4f16c250f9m 3 16 to to PART 4f16c250f9m 3 17 reach reach VERB 4f16c250f9m 3 18 its its PRON 4f16c250f9m 3 19 full full ADJ 4f16c250f9m 3 20 therapeutic therapeutic ADJ 4f16c250f9m 3 21 potential potential NOUN 4f16c250f9m 3 22 . . PUNCT 4f16c250f9m 4 1 in in ADP 4f16c250f9m 4 2 this this DET 4f16c250f9m 4 3 study study NOUN 4f16c250f9m 4 4 , , PUNCT 4f16c250f9m 4 5 we we PRON 4f16c250f9m 4 6 leveraged leverage VERB 4f16c250f9m 4 7 single single ADJ 4f16c250f9m 4 8 - - PUNCT 4f16c250f9m 4 9 cell cell NOUN 4f16c250f9m 4 10 transcriptomic transcriptomic NOUN 4f16c250f9m 4 11 and and CCONJ 4f16c250f9m 4 12 trajectory trajectory NOUN 4f16c250f9m 4 13 analyses analysis NOUN 4f16c250f9m 4 14 to to PART 4f16c250f9m 4 15 delineate delineate VERB 4f16c250f9m 4 16 time time NOUN 4f16c250f9m 4 17 dynamics dynamic NOUN 4f16c250f9m 4 18 after after ADP 4f16c250f9m 4 19 chemotherapy chemotherapy NOUN 4f16c250f9m 4 20 priming priming NOUN 4f16c250f9m 4 21 . . PUNCT 4f16c250f9m 5 1 we we PRON 4f16c250f9m 5 2 found find VERB 4f16c250f9m 5 3 that that SCONJ 4f16c250f9m 5 4 metronomic metronomic ADJ 4f16c250f9m 5 5 chemotherapy chemotherapy NOUN 4f16c250f9m 5 6 ( ( PUNCT 4f16c250f9m 5 7 mct mct PROPN 4f16c250f9m 5 8 ) ) PUNCT 4f16c250f9m 5 9 treatment treatment NOUN 4f16c250f9m 5 10 led lead VERB 4f16c250f9m 5 11 to to ADP 4f16c250f9m 5 12 an an DET 4f16c250f9m 5 13 accelerated accelerate VERB 4f16c250f9m 5 14 t t PROPN 4f16c250f9m 5 15 cell cell NOUN 4f16c250f9m 5 16 exhaustion exhaustion NOUN 4f16c250f9m 5 17 through through ADP 4f16c250f9m 5 18 cxcl16mediated cxcl16mediate VERB 4f16c250f9m 5 19 recruitment recruitment NOUN 4f16c250f9m 5 20 of of ADP 4f16c250f9m 5 21 peripheral peripheral ADJ 4f16c250f9m 5 22 immature immature ADJ 4f16c250f9m 5 23 myeloid myeloid ADJ 4f16c250f9m 5 24 cells cell NOUN 4f16c250f9m 5 25 and and CCONJ 4f16c250f9m 5 26 expansion expansion NOUN 4f16c250f9m 5 27 of of ADP 4f16c250f9m 5 28 stat1driven stat1driven ADV 4f16c250f9m 5 29 pd pd PROPN 4f16c250f9m 5 30 - - PUNCT 4f16c250f9m 5 31 l1 l1 PROPN 4f16c250f9m 5 32 expressing express VERB 4f16c250f9m 5 33 myeloid myeloid ADJ 4f16c250f9m 5 34 cells cell NOUN 4f16c250f9m 5 35 . . PUNCT 4f16c250f9m 6 1 inhibiting inhibit VERB 4f16c250f9m 6 2 stat1 stat1 PROPN 4f16c250f9m 6 3 signaling signal VERB 4f16c250f9m 6 4 in in ADP 4f16c250f9m 6 5 mct mct PROPN 4f16c250f9m 6 6 - - PUNCT 4f16c250f9m 6 7 primed prime VERB 4f16c250f9m 6 8 breast breast NOUN 4f16c250f9m 6 9 cancer cancer NOUN 4f16c250f9m 6 10 relieved relieve VERB 4f16c250f9m 6 11 t t PROPN 4f16c250f9m 6 12 cell cell NOUN 4f16c250f9m 6 13 exhaustion exhaustion NOUN 4f16c250f9m 6 14 and and CCONJ 4f16c250f9m 6 15 significantly significantly ADV 4f16c250f9m 6 16 enhanced enhance VERB 4f16c250f9m 6 17 the the DET 4f16c250f9m 6 18 efficacy efficacy NOUN 4f16c250f9m 6 19 of of ADP 4f16c250f9m 6 20 anti anti ADJ 4f16c250f9m 6 21 - - ADJ 4f16c250f9m 6 22 pd-1 pd-1 ADJ 4f16c250f9m 6 23 icb icb PROPN 4f16c250f9m 6 24 treatment treatment NOUN 4f16c250f9m 6 25 . . PUNCT 4f16c250f9m 7 1 our our PRON 4f16c250f9m 7 2 study study NOUN 4f16c250f9m 7 3 leveraged leverage VERB 4f16c250f9m 7 4 single single ADJ 4f16c250f9m 7 5 - - PUNCT 4f16c250f9m 7 6 cell cell NOUN 4f16c250f9m 7 7 analyses analysis NOUN 4f16c250f9m 7 8 to to PART 4f16c250f9m 7 9 dissect dissect VERB 4f16c250f9m 7 10 the the DET 4f16c250f9m 7 11 dynamics dynamic NOUN 4f16c250f9m 7 12 of of ADP 4f16c250f9m 7 13 breast breast NOUN 4f16c250f9m 7 14 cancer cancer NOUN 4f16c250f9m 7 15 time time NOUN 4f16c250f9m 7 16 and and CCONJ 4f16c250f9m 7 17 provides provide VERB 4f16c250f9m 7 18 a a DET 4f16c250f9m 7 19 pre pre ADJ 4f16c250f9m 7 20 - - ADJ 4f16c250f9m 7 21 clinical clinical ADJ 4f16c250f9m 7 22 rationale rationale NOUN 4f16c250f9m 7 23 to to PART 4f16c250f9m 7 24 translate translate VERB 4f16c250f9m 7 25 the the DET 4f16c250f9m 7 26 anti anti ADJ 4f16c250f9m 7 27 - - ADJ 4f16c250f9m 7 28 stat1 stat1 ADJ 4f16c250f9m 7 29 plus plus CCONJ 4f16c250f9m 7 30 anti anti ADJ 4f16c250f9m 7 31 - - ADJ 4f16c250f9m 7 32 pd-1 pd-1 ADJ 4f16c250f9m 7 33 combinatorial combinatorial ADJ 4f16c250f9m 7 34 immunotherapy immunotherapy NOUN 4f16c250f9m 7 35 regimen regiman NOUN 4f16c250f9m 7 36 to to PART 4f16c250f9m 7 37 maximize maximize VERB 4f16c250f9m 7 38 icb icb PROPN 4f16c250f9m 7 39 's 's PART 4f16c250f9m 7 40 efficacy efficacy NOUN 4f16c250f9m 7 41 . . PUNCT